Gapdh (glyceraldehyde-3-phosphate dehydrogenase) - Rat Genome Database

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Gene: Gapdh (glyceraldehyde-3-phosphate dehydrogenase) Rattus norvegicus
Analyze
Symbol: Gapdh (Ensembl: LOC108351137)
Name: glyceraldehyde-3-phosphate dehydrogenase
RGD ID: 2661
Description: Enables several functions, including glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity; identical protein binding activity; and peptidyl-cysteine S-nitrosylase activity. Involved in several processes, including gluconeogenesis; intracellular signaling cassette; and negative regulation of vascular associated smooth muscle cell apoptotic process. Located in cytosol; microtubule cytoskeleton; and nucleus. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Used to study Alzheimer's disease and middle cerebral artery infarction. Biomarker of several diseases, including brain glioma; diabetic retinopathy; obesity; oral squamous cell carcinoma; and rheumatic heart disease. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human GAPDH (glyceraldehyde-3-phosphate dehydrogenase); PARTICIPATES IN gluconeogenesis pathway; electron transport chain pathway; Fanconi syndrome pathway; INTERACTS WITH (-)-selegiline; 1,3-dinitrobenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 38 kDa BFA-dependent ADP-ribosylation substrate; BARS-38; Gapd; peptidyl-cysteine S-nitrosylase GAPDH
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gapdh-ps1   Gapdh-ps118   Gapdh-ps2   Gapdh-ps36   Gapdh-ps49  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,648,592 - 159,653,436 (-)NCBIGRCr8
mRatBN7.24157,962,312 - 157,967,158 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,962,343 - 157,966,235 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.04157,676,336 - 157,680,322 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04224,693,580 - 224,697,455 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44161,282,215 - 161,286,090 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4146,699,388 - 146,703,263 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-selegiline  (EXP,ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (ISO)
1,2-naphthoquinone  (ISO)
1,3-dinitrobenzene  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-bromohexadecanoic acid  (EXP)
2-methoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,7-dihydropurine-6-thione  (ISO)
3-bromopyruvic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-nitropropanoic acid  (EXP)
3-phosphoglyceric acid  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxynon-2-enal  (ISO)
4-tert-Octylphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
7-NITROINDAZOLE  (EXP)
9-cis-retinoic acid  (ISO)
acetaldehyde  (ISO)
acetamide  (EXP)
acetic acid  (ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
ADP  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
aloxistatin  (ISO)
alpha-amanitin  (ISO)
alpha-hexachlorocyclohexane  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP,ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
ATP  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
beta-D-fructofuranose 1,6-bisphosphate  (EXP)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
boric acid  (ISO)
bromochloroacetic acid  (ISO)
buten-2-one  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
capsaicin  (EXP,ISO)
captan  (ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
cerium trichloride  (ISO)
chloroacetaldehyde  (EXP)
chloroacetic acid  (EXP)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
clozapine  (EXP,ISO)
cobalt dichloride  (ISO)
cobalt(2+) sulfate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (EXP,ISO)
cumene hydroperoxide  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
D-fructofuranose 1,6-bisphosphate  (EXP)
D-glucose  (EXP,ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP)
dihydroartemisinin  (ISO)
Diisodecyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
Diosbulbin B  (ISO)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dizocilpine maleate  (EXP)
dopamine  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
fenbuconazole  (ISO)
fenthion  (ISO)
fentin chloride  (ISO)
ferric ammonium citrate  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
FR900359  (ISO)
fructose  (ISO)
furan  (EXP)
genistein  (EXP)
glafenine  (EXP)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glyceraldehyde 3-phosphate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphite  (ISO)
haloperidol  (EXP)
Heptelidic acid  (EXP)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
indometacin  (ISO)
isoflavones  (EXP)
isoniazide  (EXP)
ivermectin  (ISO)
keto-D-fructose 1,6-bisphosphate  (EXP)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
L-ethionine  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
Macrosphelide A  (ISO)
mebendazole  (ISO)
mercaptopurine  (ISO)
methanol  (EXP)
methoxychlor  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (EXP)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
NAD zwitterion  (EXP,ISO)
NAD(+)  (EXP,ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nilutamide  (EXP)
nitric oxide  (EXP,ISO)
obeticholic acid  (ISO)
okadaic acid  (ISO)
omeprazole  (EXP)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
p-tert-Amylphenol  (EXP)
paracetamol  (EXP)
paraquat  (EXP)
PCB138  (EXP)
pepstatin A  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
pirinixic acid  (EXP)
polymyxin B2  (ISO)
potassium dichromate  (EXP)
progesterone  (EXP)
promethazine  (EXP)
prostaglandin A1  (ISO)
purine-6-thiol  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (EXP,ISO)
Rebamipide  (EXP)
resveratrol  (EXP)
retinyl acetate  (ISO)
rimonabant  (ISO)
rotenone  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
Salinomycin  (ISO)
selenium atom  (ISO)
serotonin  (ISO)
serpentine asbestos  (EXP)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (EXP)
sodium fluoride  (ISO)
sucrose  (ISO)
sunitinib  (ISO)
superoxide  (EXP,ISO)
syringic acid  (ISO)
T-2 toxin  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetraethylenepentamine  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenylstannane  (ISO)
trovafloxacin  (EXP)
vanillin  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Association and heterogeneity at the GAPDH locus in Alzheimer's disease. Allen M, etal., Neurobiol Aging. 2012 Jan;33(1):203.e25-33. doi: 10.1016/j.neurobiolaging.2010.08.002. Epub 2010 Sep 23.
2. Interactions among p22, glyceraldehyde-3-phosphate dehydrogenase and microtubules. Andrade J, etal., Biochem J. 2004 Dec 1;384(Pt 2):327-36.
3. Glyceraldehyde-3-phosphate dehydrogenase interacts with phosphorylated Akt resulting from increased blood glucose in rat cardiac muscle. Baba T, etal., FEBS Lett. 2010 Jul 2;584(13):2796-800. doi: 10.1016/j.febslet.2010.05.015. Epub 2010 May 17.
4. Lysine post-translational modification of glyceraldehyde-3-phosphate dehydrogenase regulates hepatic and systemic metabolism. Bond ST, etal., FASEB J. 2017 Jun;31(6):2592-2602. doi: 10.1096/fj.201601215R. Epub 2017 Mar 3.
5. Key enzymes of carbohydrate metabolism as targets of the 11.5-kDa Zn(2+)-binding protein (parathymosin). Brand IA and Heinickel A, J Biol Chem. 1991 Nov 5;266(31):20984-9.
6. Interaction of glyceraldehyde-3-phosphate dehydrogenase in the light-induced rod alpha-transducin translocation. Chen J, etal., J Neurochem. 2008 Mar;104(5):1280-92. Epub 2007 Nov 17.
7. Increased myocardial expression of RAMP1 and RAMP3 in rats with chronic heart failure. Cueille C, etal., Biochem Biophys Res Commun 2002 Jun 7;294(2):340-6.
8. Assessment of GAPDH expression by quantitative real time PCR in blood of Moroccan AD cases. El Kadmiri N, etal., J Clin Neurosci. 2017 Jun;40:24-26. doi: 10.1016/j.jocn.2016.12.007. Epub 2017 Jan 10.
9. Isolation and complete sequence of a functional human glyceraldehyde-3-phosphate dehydrogenase gene. Ercolani L, etal., J Biol Chem 1988 Oct 25;263(30):15335-41.
10. Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family. Fort P, etal., Nucleic Acids Res 1985 Mar 11;13(5):1431-42.
11. Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC). Foster LJ, etal., J Proteome Res. 2006 Jan;5(1):64-75.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Spatial profiles of markers of glycolysis, mitochondria, and proton pumps in a rat glioma suggest coordinated programming for proliferation. Grillon E, etal., BMC Res Notes. 2015 Jun 2;8:207. doi: 10.1186/s13104-015-1191-z.
15. S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding. Hara MR, etal., Nat Cell Biol. 2005 Jul;7(7):665-74. Epub 2005 Jun 12.
16. Nuclear complex of glyceraldehyde-3-phosphate dehydrogenase and DNA repair enzyme apurinic/apyrimidinic endonuclease I protect smooth muscle cells against oxidant-induced cell death. Hou X, etal., FASEB J. 2017 Jul;31(7):3179-3192. doi: 10.1096/fj.201601082R. Epub 2017 Apr 12.
17. Inhibiting a spinal cord signaling pathway protects against ischemia injury in rats. Huo J, etal., J Thorac Cardiovasc Surg. 2018 Jul 30. pii: S0022-5223(18)32035-X. doi: 10.1016/j.jtcvs.2018.07.045.
18. GAPDH/Siah1 cascade is involved in traumatic spinal cord injury and could be attenuated by sivelestat sodium. Huo J, etal., Neuroscience. 2016 Aug 25;330:171-80. doi: 10.1016/j.neuroscience.2016.05.054. Epub 2016 May 30.
19. Impaired GAPDH-induced mitophagy contributes to the pathology of Huntington's disease. Hwang S, etal., EMBO Mol Med. 2015 Oct;7(10):1307-26. doi: 10.15252/emmm.201505256.
20. Identification of major Ca(2+)/calmodulin-dependent protein kinase phosphatase-binding proteins in brain: biochemical analysis of the interaction. Ishida A, etal., Arch Biochem Biophys. 2005 Mar 1;435(1):134-46.
21. Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin delta: interaction with actin, clathrin and tubulin. Ivings L, etal., Biochem J 2002 May 1;363(Pt 3):599-608.
22. Role of glyceraldehyde 3-phosphate dehydrogenase in the development and progression of diabetic retinopathy. Kanwar M and Kowluru RA, Diabetes. 2009 Jan;58(1):227-34. Epub 2008 Oct 13.
23. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
24. GAPDH mediates nitrosylation of nuclear proteins. Kornberg MD, etal., Nat Cell Biol. 2010 Nov;12(11):1094-100. doi: 10.1038/ncb2114. Epub 2010 Oct 24.
25. In situ analysis of mTORC1/2 and cellular metabolism-related proteins in human Lymphangioleiomyomatosis. Krencz I, etal., Hum Pathol. 2018 Sep;79:199-207. doi: 10.1016/j.humpath.2018.05.018. Epub 2018 Jun 6.
26. Further examination of the candidate genes in chromosome 12p13 locus for late-onset Alzheimer disease. Lee JH, etal., Neurogenetics. 2008 May;9(2):127-38. doi: 10.1007/s10048-008-0122-8. Epub 2008 Mar 14.
27. Trifluoperazine activates and releases latent ATP-generating enzymes associated with the synaptic plasma membrane. Leung TK, etal., J Neurochem 1987 Jul;49(1):232-8.
28. Proteomic analysis of mitral valve in Lewis rat with acute rheumatic heart disease. Li W, etal., Int J Clin Exp Pathol. 2015 Nov 1;8(11):14151-60. eCollection 2015.
29. Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family. Li Y, etal., Proc Natl Acad Sci U S A 2004 Nov 2;101(44):15688-93. Epub 2004 Oct 26.
30. 1.5 kb mRNA abundantly expressed in rat tumors encodes a 37 kilodalton protein in vitro. Maehara Y, etal., Biochem Biophys Res Commun 1985 Sep 16;131(2):800-5.
31. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
32. Disruption of GluR2/GAPDH Complex Interaction by TAT-GluR2NT1-3-2 Peptide Protects against Neuronal Death Induced by Epilepsy. Mi Q, etal., Ann Clin Lab Sci. 2018 Jul;48(4):460-468.
33. Nuclear-translocated Glyceraldehyde-3-phosphate Dehydrogenase Promotes Poly(ADP-ribose) Polymerase-1 Activation during Oxidative/Nitrosative Stress in Stroke. Nakajima H, etal., J Biol Chem. 2015 Jun 5;290(23):14493-503. doi: 10.1074/jbc.M114.635607. Epub 2015 Apr 16.
34. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
35. An increase in S-glutathionylated proteins in the Alzheimer's disease inferior parietal lobule, a proteomics approach. Newman SF, etal., J Neurosci Res. 2007 May 15;85(7):1506-14. doi: 10.1002/jnr.21275.
36. Molecular and functional characterization of ERG, KCNQ, and KCNE subtypes in rat stomach smooth muscle. Ohya S, etal., Am J Physiol Gastrointest Liver Physiol 2002 Feb;282(2):G277-87.
37. Identification of reliable reference genes for quantitative gene expression studies in oral squamous cell carcinomas compared to adjacent normal tissues in the F344 rat model. Peng X and McCormick DL, Oncol Rep. 2016 Aug;36(2):1076-84. doi: 10.3892/or.2016.4883. Epub 2016 Jun 16.
38. Post-transcriptional regulation of glyceraldehyde-3-phosphate-dehydrogenase gene expression in rat tissues. Piechaczyk M, etal., Nucleic Acids Res 1984 Sep 25;12(18):6951-63.
39. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
40. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
41. Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Protein-Protein Interaction Inhibitor Reveals a Non-catalytic Role for GAPDH Oligomerization in Cell Death. Qvit N, etal., J Biol Chem. 2016 Jun 24;291(26):13608-21. doi: 10.1074/jbc.M115.711630. Epub 2016 Apr 27.
42. Response of rat cerebral glycolytic enzymes to hyperammonemic states. Ratnakumari L and Murthy CR, Neurosci Lett. 1993 Oct 14;161(1):37-40.
43. GOA pipeline RGD automated data pipeline
44. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
45. Monochloroacetic acid inhibits liver gluconeogenesis by inactivating glyceraldehyde-3-phosphate dehydrogenase. Sakai A, etal., Chem Res Toxicol. 2005 Feb;18(2):277-82.
46. GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation. Sen N, etal., Neuron. 2009 Jul 16;63(1):81-91. doi: 10.1016/j.neuron.2009.05.024.
47. Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus. Shakib K, etal., Proteomics. 2005 Jul;5(11):2819-38.
48. Decrease of dehydrogenase activity of cerebral glyceraldehyde-3-phosphate dehydrogenase in different animal models of Alzheimer's disease. Shalova IN, etal., Biochim Biophys Acta. 2007 May;1770(5):826-32. doi: 10.1016/j.bbagen.2007.01.014. Epub 2007 Feb 4.
49. Enhanced anti-obesity effects of complex of resistant starch and chitosan in high fat diet fed rats. Si X, etal., Carbohydr Polym. 2017 Feb 10;157:834-841. doi: 10.1016/j.carbpol.2016.10.042. Epub 2016 Oct 17.
50. HIF-1a and PPAR¿ during physiological cardiac hypertrophy induced by pregnancy: Transcriptional activities and effects on target genes. Soñanez-Organis JG, etal., Gene. 2016 Oct 15;591(2):376-81. doi: 10.1016/j.gene.2016.06.025. Epub 2016 Jun 14.
51. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
52. Glyceraldehyde 3-phosphate dehydrogenase is required for band 3 (anion exchanger 1) membrane residency in the mammalian kidney. Su Y, etal., Am J Physiol Renal Physiol. 2011 Jan;300(1):F157-66. doi: 10.1152/ajprenal.00228.2010. Epub 2010 Oct 27.
53. Over-expression of GAPDH induces apoptosis in COS-7 cells transfected with cloned GAPDH cDNAs. Tajima H, etal., Neuroreport 1999 Jul 13;10(10):2029-33.
54. Thyroid hormone treatment decreases hepatic glucose production and renal reabsorption of glucose in alloxan-induced diabetic Wistar rats. Teixeira SD, etal., Physiol Rep. 2016 Sep;4(18). pii: 4/18/e12961. doi: 10.14814/phy2.12961.
55. Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene. Tso JY, etal., Nucleic Acids Res 1985 Apr 11;13(7):2485-502.
56. Maternal diabetes in vivo and high glucose in vitro diminish GAPDH activity in rat embryos. Wentzel P, etal., Diabetes. 2003 May;52(5):1222-8.
57. The synthesis of ATP by glycolytic enzymes in the postsynaptic density and the effect of endogenously generated nitric oxide. Wu K, etal., Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13273-8.
Additional References at PubMed
PMID:3796661   PMID:7144574   PMID:10559001   PMID:11487543   PMID:11785981   PMID:12519789   PMID:12753082   PMID:14651853   PMID:14741744   PMID:15159393   PMID:15479637   PMID:15489334  
PMID:15665293   PMID:16170200   PMID:16418269   PMID:16627065   PMID:16751257   PMID:17426931   PMID:17488287   PMID:17634366   PMID:17962088   PMID:18698006   PMID:18720057   PMID:18837965  
PMID:19022411   PMID:19056867   PMID:19075228   PMID:19131967   PMID:19182904   PMID:19190083   PMID:19199708   PMID:19292454   PMID:19470756   PMID:19723108   PMID:19903941   PMID:19940145  
PMID:19946888   PMID:19950597   PMID:20392205   PMID:20458337   PMID:20518697   PMID:21210726   PMID:21257285   PMID:21362503   PMID:21413931   PMID:21482559   PMID:21539824   PMID:21630459  
PMID:21904640   PMID:21988832   PMID:22252379   PMID:22420779   PMID:22832495   PMID:22871113   PMID:23027902   PMID:23071094   PMID:23106098   PMID:23360709   PMID:23376485   PMID:23527007  
PMID:23530063   PMID:23533145   PMID:23979707   PMID:24101517   PMID:24137001   PMID:24507776   PMID:24670206   PMID:26316108   PMID:26748070   PMID:26945066   PMID:28174179   PMID:28259758  
PMID:29476059   PMID:32438512   PMID:32875725   PMID:33539626   PMID:33546324   PMID:35352799   PMID:35871495   PMID:36755387   PMID:37863305  


Genomics

Comparative Map Data
Gapdh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,648,592 - 159,653,436 (-)NCBIGRCr8
mRatBN7.24157,962,312 - 157,967,158 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,962,343 - 157,966,235 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.04157,676,336 - 157,680,322 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04224,693,580 - 224,697,455 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44161,282,215 - 161,286,090 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4146,699,388 - 146,703,263 (-)NCBICelera
Cytogenetic Map4q42NCBI
GAPDH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,534,517 - 6,538,371 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,534,512 - 6,538,374 (+)EnsemblGRCh38hg38GRCh38
GRCh37126,643,683 - 6,647,537 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,513,918 - 6,517,797 (+)NCBINCBI36Build 36hg18NCBI36
Build 34126,513,944 - 6,517,797NCBI
Celera128,260,518 - 8,264,397 (+)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef126,497,829 - 6,501,781 (+)NCBIHuRef
CHM1_1126,642,592 - 6,646,544 (+)NCBICHM1_1
T2T-CHM13v2.0126,544,873 - 6,548,727 (+)NCBIT2T-CHM13v2.0
Gapdh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396125,138,812 - 125,143,450 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6125,138,678 - 125,143,430 (-)EnsemblGRCm39 Ensembl
GRCm386125,161,852 - 125,166,467 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6125,161,715 - 125,166,467 (-)EnsemblGRCm38mm10GRCm38
MGSCv376125,111,870 - 125,115,601 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366125,128,554 - 125,131,222 (-)NCBIMGSCv36mm8
Celera6126,831,711 - 126,835,442 (-)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.32NCBI
Gapdh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554134,162,467 - 4,166,783 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554134,162,467 - 4,166,783 (+)NCBIChiLan1.0ChiLan1.0
GAPDH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21012,096,075 - 12,100,140 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11212,092,832 - 12,096,897 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0126,665,218 - 6,669,170 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1126,583,895 - 6,587,729 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl126,583,895 - 6,587,729 (+)Ensemblpanpan1.1panPan2
LOC100688969
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X51,925,654 - 51,926,724 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX42,758,798 - 42,759,848 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X52,892,500 - 52,893,549 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X50,867,280 - 50,868,330 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X52,198,694 - 52,199,710 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X52,119,573 - 52,120,589 (+)NCBIUU_Cfam_GSD_1.0
Gapdh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,575,598 - 102,580,238 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049367091,243,149 - 1,247,782 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GAPDH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl564,129,679 - 64,133,991 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1564,129,678 - 64,135,194 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2566,446,302 - 66,449,510 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap5q12-q21NCBI
GAPDH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1116,569,029 - 6,572,877 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660631,653,527 - 1,657,405 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gapdh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248603,257,853 - 3,261,735 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248603,257,805 - 3,261,736 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gapdh
17 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:56
Count of miRNA genes:48
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000050443
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4157680158158841762Rat
1581574Eae20Experimental allergic encephalomyelitis QTL 207.8nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)4153031106158841762Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat

Markers in Region
PMC122612P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q33UniSTS
Cytogenetic Map8q22UniSTS
Cytogenetic Map4q42UniSTS
Cytogenetic Map3q21UniSTS
Cytogenetic Map10q26UniSTS
Cytogenetic Map18q12.1UniSTS
PMC128021P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q33UniSTS
Cytogenetic Map8q22UniSTS
Cytogenetic Map18q12.1UniSTS
Cytogenetic Map11q22UniSTS
Cytogenetic Map10q32.1UniSTS
Cytogenetic Map4q42UniSTS
Cytogenetic Map3q21UniSTS
Cytogenetic Map19p11UniSTS
Cytogenetic Map10q26UniSTS
Cytogenetic Map5q24UniSTS
Cytogenetic Map6q32UniSTS
PMC133764P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q22UniSTS
Cytogenetic Map9q13UniSTS
Cytogenetic Map16q11UniSTS
Cytogenetic Map5q33UniSTS
Cytogenetic Map8q22UniSTS
Cytogenetic Map4q42UniSTS
Cytogenetic Map11q22UniSTS
Cytogenetic Map2q34UniSTS
Cytogenetic Map10q26UniSTS
Cytogenetic Map16p14UniSTS
Cytogenetic Map18q12.1UniSTS
PMC15575P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q33UniSTS
Cytogenetic Map8q22UniSTS
Cytogenetic Map18q12.1UniSTS
Cytogenetic Map4q42UniSTS
Cytogenetic Map10q32.1UniSTS
Cytogenetic Map19p11UniSTS
Cytogenetic Map2q42UniSTS
Cytogenetic Map11q22UniSTS
PMC164515P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q33UniSTS
Cytogenetic Map11q22UniSTS
Cytogenetic Map10q32.1UniSTS
Cytogenetic Map4q42UniSTS
Cytogenetic Map3q21UniSTS
Cytogenetic Map19p11UniSTS
Cytogenetic Map6q32UniSTS
PMC186377P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q33UniSTS
Cytogenetic Map4q42UniSTS
Cytogenetic Map8q22UniSTS
PMC26839P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16q11UniSTS
Cytogenetic Map5q33UniSTS
Cytogenetic Map8q22UniSTS
Cytogenetic Map4q42UniSTS
Cytogenetic Map19p11UniSTS
Cytogenetic Map15q21UniSTS
Cytogenetic Map16p14UniSTS
Cytogenetic Map18q12.1UniSTS
PMC316856P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16q11UniSTS
Cytogenetic Map5q33UniSTS
Cytogenetic Map8q22UniSTS
Cytogenetic Map4q42UniSTS
Cytogenetic Map11q22UniSTS
Cytogenetic Map10q32.1UniSTS
Cytogenetic Map16p14UniSTS
Cytogenetic Map18q12.1UniSTS
PMC327192P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q33UniSTS
Cytogenetic Map4q42UniSTS
Cytogenetic Map16p14UniSTS
Cytogenetic Map19p11UniSTS
PMC329392P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q33UniSTS
Cytogenetic Map8q22UniSTS
Cytogenetic Map18q12.1UniSTS
Cytogenetic Map11q22UniSTS
Cytogenetic Map4q42UniSTS
Cytogenetic Map3q21UniSTS
Cytogenetic Map19p11UniSTS
Cytogenetic Map15q21UniSTS
Cytogenetic Map2q42UniSTS
Cytogenetic Map10q32.1UniSTS
PMC128235P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q33UniSTS
Cytogenetic Map8q22UniSTS
Cytogenetic Map18q12.1UniSTS
Cytogenetic Map11q22UniSTS
Cytogenetic Map10q32.1UniSTS
Cytogenetic Map4q42UniSTS
Cytogenetic Map13q22UniSTS
Cytogenetic Map19p11UniSTS
Cytogenetic Map15q21UniSTS
Cytogenetic Map7q13UniSTS
Cytogenetic Map2q42UniSTS
Cytogenetic Map3q21UniSTS
RH140227  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24157,961,933 - 157,962,127 (+)MAPPERmRatBN7.2
Rnor_6.04157,675,972 - 157,676,165NCBIRnor6.0
Rnor_5.04224,693,156 - 224,693,349UniSTSRnor5.0
RGSC_v3.44161,281,791 - 161,281,984UniSTSRGSC3.4
Celera4146,698,964 - 146,699,157UniSTS
RH 3.4 Map41005.8UniSTS
Cytogenetic Map4q42UniSTS
PMC193571P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q33UniSTS
Cytogenetic Map4q42UniSTS
Cytogenetic Map10q32.1UniSTS
PMC104479P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0X55,897,275 - 55,897,778NCBIRnor5.0
Rnor_5.01207,898,087 - 207,898,589NCBIRnor5.0
Rnor_5.01208,042,287 - 208,042,789NCBIRnor5.0
RGSC_v3.4X93,852,831 - 93,853,333UniSTSRGSC3.4
RGSC_v3.41189,771,940 - 189,772,441UniSTSRGSC3.4
CeleraX72,115,994 - 72,116,496UniSTS
Celera1182,631,486 - 182,631,987UniSTS
Cytogenetic MapXq31UniSTS
Cytogenetic Map4q42UniSTS
Cytogenetic Map1q37UniSTS
PMC112827P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0X55,897,275 - 55,897,396NCBIRnor5.0
Rnor_5.01207,898,087 - 207,898,207NCBIRnor5.0
Rnor_5.01208,042,287 - 208,042,407NCBIRnor5.0
RGSC_v3.4X93,852,831 - 93,852,951UniSTSRGSC3.4
RGSC_v3.41189,771,940 - 189,772,059UniSTSRGSC3.4
CeleraX72,115,994 - 72,116,114UniSTS
Celera1182,631,486 - 182,631,605UniSTS
Cytogenetic MapXq31UniSTS
Cytogenetic Map4q42UniSTS
Cytogenetic Map1q37UniSTS
PMC115884P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0X55,897,276 - 55,897,582NCBIRnor5.0
Rnor_5.01207,898,088 - 207,898,393NCBIRnor5.0
Rnor_5.01208,042,288 - 208,042,593NCBIRnor5.0
RGSC_v3.4X93,852,832 - 93,853,137UniSTSRGSC3.4
RGSC_v3.41189,771,941 - 189,772,245UniSTSRGSC3.4
CeleraX72,115,995 - 72,116,300UniSTS
Celera1182,631,487 - 182,631,791UniSTS
Cytogenetic MapXq31UniSTS
Cytogenetic Map4q42UniSTS
Cytogenetic Map1q37UniSTS
PMC21468P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0X55,897,276 - 55,897,638NCBIRnor5.0
Rnor_5.01207,898,088 - 207,898,449NCBIRnor5.0
Rnor_5.01208,042,288 - 208,042,649NCBIRnor5.0
RGSC_v3.4X93,852,832 - 93,853,193UniSTSRGSC3.4
RGSC_v3.41189,771,941 - 189,772,301UniSTSRGSC3.4
CeleraX72,115,995 - 72,116,356UniSTS
Celera1182,631,487 - 182,631,847UniSTS
Cytogenetic MapXq31UniSTS
Cytogenetic Map4q42UniSTS
Cytogenetic Map1q37UniSTS
PMC266773P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01207,898,088 - 207,898,449NCBIRnor5.0
Rnor_5.0X55,897,276 - 55,897,638NCBIRnor5.0
Rnor_5.01208,042,288 - 208,042,649NCBIRnor5.0
RGSC_v3.41189,771,941 - 189,772,301UniSTSRGSC3.4
RGSC_v3.4X93,852,832 - 93,853,193UniSTSRGSC3.4
Celera1182,631,487 - 182,631,847UniSTS
CeleraX72,115,995 - 72,116,356UniSTS
Cytogenetic Map1q37UniSTS
Cytogenetic MapXq31UniSTS
Cytogenetic Map4q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 35 12 12 12 8 11 47 22 13 8
Medium 3 8 45 29 19 29 27 13 28 11
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB017801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC115415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC059110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC087743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ403053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M11561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M17701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M29341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U75401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000050443   ⟹   ENSRNOP00000040878
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4157,962,361 - 157,966,235 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110793   ⟹   ENSRNOP00000084281
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4157,962,343 - 157,966,174 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114924   ⟹   ENSRNOP00000088495
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4157,962,356 - 157,965,978 (-)Ensembl
RefSeq Acc Id: NM_017008   ⟹   NP_058704
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84159,648,592 - 159,652,467 (-)NCBI
mRatBN7.24157,962,358 - 157,966,233 (-)NCBI
Rnor_6.04157,676,396 - 157,680,271 (-)NCBI
Rnor_5.04224,693,580 - 224,697,455 (-)NCBI
RGSC_v3.44161,282,215 - 161,286,090 (-)RGD
Celera4146,699,388 - 146,703,263 (-)RGD
Sequence:
RefSeq Acc Id: XM_039107008   ⟹   XP_038962936
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84159,648,592 - 159,653,436 (-)NCBI
mRatBN7.24157,962,312 - 157,967,158 (-)NCBI
RefSeq Acc Id: XM_063285517   ⟹   XP_063141587
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84159,648,592 - 159,652,464 (-)NCBI
RefSeq Acc Id: XM_063285518   ⟹   XP_063141588
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84159,648,592 - 159,652,060 (-)NCBI
RefSeq Acc Id: XM_063285519   ⟹   XP_063141589
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84159,648,592 - 159,652,459 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_058704   ⟸   NM_017008
- UniProtKB: Q5M916 (UniProtKB/Swiss-Prot),   P09328 (UniProtKB/Swiss-Prot),   Q9QWU4 (UniProtKB/Swiss-Prot),   P04797 (UniProtKB/Swiss-Prot),   A6ILS6 (UniProtKB/TrEMBL),   A0A8L2QM97 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038962936   ⟸   XM_039107008
- Peptide Label: isoform X1
- UniProtKB: Q5M916 (UniProtKB/Swiss-Prot),   P09328 (UniProtKB/Swiss-Prot),   P04797 (UniProtKB/Swiss-Prot),   Q9QWU4 (UniProtKB/Swiss-Prot),   A6ILS6 (UniProtKB/TrEMBL),   A0A8L2QM97 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000040878   ⟸   ENSRNOT00000050443
RefSeq Acc Id: ENSRNOP00000084281   ⟸   ENSRNOT00000110793
RefSeq Acc Id: ENSRNOP00000088495   ⟸   ENSRNOT00000114924
RefSeq Acc Id: XP_063141587   ⟸   XM_063285517
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063141589   ⟸   XM_063285519
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063141588   ⟸   XM_063285518
- Peptide Label: isoform X3
Protein Domains
Glyceraldehyde 3-phosphate dehydrogenase NAD(P)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04797-F1-model_v2 AlphaFold P04797 1-333 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2661 AgrOrtholog
BioCyc Gene G2FUF-43009 BioCyc
Ensembl Genes ENSRNOG00000018630 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055006222 UniProtKB/Swiss-Prot
  ENSRNOG00055009333 UniProtKB/Swiss-Prot
  ENSRNOG00055030697 UniProtKB/Swiss-Prot
  ENSRNOG00060032665 UniProtKB/Swiss-Prot
  ENSRNOG00065020177 UniProtKB/Swiss-Prot
  ENSRNOG00065032955 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000050443 ENTREZGENE
  ENSRNOT00000050443.5 UniProtKB/TrEMBL
  ENSRNOT00000110793.1 UniProtKB/TrEMBL
  ENSRNOT00000114924.1 UniProtKB/TrEMBL
  ENSRNOT00055010101 UniProtKB/Swiss-Prot
  ENSRNOT00055015786 UniProtKB/Swiss-Prot
  ENSRNOT00055053257 UniProtKB/Swiss-Prot
  ENSRNOT00060056622 UniProtKB/Swiss-Prot
  ENSRNOT00065034039 UniProtKB/Swiss-Prot
  ENSRNOT00065056696 UniProtKB/Swiss-Prot
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6919611 IMAGE-MGC_LOAD
  IMAGE:7321006 IMAGE-MGC_LOAD
InterPro GlycerAld/Erythrose_P_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GlycerAld_3-P_DH_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GlycerAld_3-P_DH_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GlycerAld_3-P_DH_NAD(P)-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyceraldehyde-3-P_DH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24383 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105280 IMAGE-MGC_LOAD
  MGC:72650 IMAGE-MGC_LOAD
NCBI Gene 24383 ENTREZGENE
PANTHER GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10836 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Gp_dh_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gp_dh_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gapdh PhenoGen
PIRSF GAP_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS G3PDHDRGNASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GAPDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018630 RatGTEx
  ENSRNOG00055006222 RatGTEx
  ENSRNOG00055009333 RatGTEx
  ENSRNOG00055030697 RatGTEx
  ENSRNOG00060032665 RatGTEx
  ENSRNOG00065020177 RatGTEx
  ENSRNOG00065032955 RatGTEx
SMART Gp_dh_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZXG9_RAT UniProtKB/TrEMBL
  A0A8I6AIZ9_RAT UniProtKB/TrEMBL
  A0A8L2QM97 ENTREZGENE, UniProtKB/TrEMBL
  A6ILS6 ENTREZGENE, UniProtKB/TrEMBL
  G3P_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P09328 ENTREZGENE
  P97617_RAT UniProtKB/TrEMBL
  Q0QEU1_RAT UniProtKB/TrEMBL
  Q5M916 ENTREZGENE
  Q8K4T7_RAT UniProtKB/TrEMBL
  Q8K4T8_RAT UniProtKB/TrEMBL
  Q9QWU4 ENTREZGENE
UniProt Secondary P09328 UniProtKB/Swiss-Prot
  Q5M916 UniProtKB/Swiss-Prot
  Q9QWU4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-02-01 Gapdh    Gapd  glyceraldehyde-3-phosphate dehydrogenase  Symbol updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2002-06-10 Gapd  Glyceraldehyde-3-phosphate dehydrogenase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in atria and ventricles of the heart 625420
gene_expression expressed in all tissues 632774
gene_protein 333 amino acids 632774