Fth1 (ferritin heavy chain 1) - Rat Genome Database

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Gene: Fth1 (ferritin heavy chain 1) Rattus norvegicus
Analyze
Symbol: Fth1
Name: ferritin heavy chain 1
RGD ID: 2635
Description: Predicted to enable several functions, including ferroxidase activity; iron ion binding activity; and iron ion sequestering activity. Involved in negative regulation of fibroblast proliferation. Predicted to be located in autolysosome. Predicted to be active in cytosol and membrane. Biomarker of congestive heart failure and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in hemochromatosis type 5 and neurodegeneration with brain iron accumulation. Orthologous to human FTH1 (ferritin heavy chain 1); PARTICIPATES IN iron storage pathway; porphyrin and chlorophyll metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ferritin H subunit; ferritin heavy chain; Ferritin subunit H; ferritin, heavy polypeptide 1; Fth
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Fth1-ps5  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81216,052,037 - 216,054,325 (+)NCBIGRCr8
mRatBN7.21206,627,142 - 206,629,430 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1206,627,103 - 206,725,424 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1215,005,534 - 215,007,822 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,060,660 - 222,062,948 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01214,755,668 - 214,757,956 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01226,030,940 - 226,033,228 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1226,030,938 - 226,033,228 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01232,979,122 - 232,981,410 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41212,430,453 - 212,432,741 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11212,588,882 - 212,591,171 (+)NCBI
Celera1204,122,676 - 204,124,964 (+)NCBICelera
RH 3.4 Map14258.8RGD
Cytogenetic Map1q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Fth1RatChronic Cerebral Hypoperfusion  IEP 11541085protein:increased expression:hippocampusRGD 
Fth1Ratcongestive heart failure  IEP 2315110protein:decreased expression:heartRGD 
Fth1RatCOVID-19 severityISOFTH1 (Homo sapiens)30310229protein:increased expression:serum (human)RGD 
Fth1RatCOVID-19 severityISOFTH1 (Homo sapiens)32698682associated with hyperglycemia and protein:increased expression:serum (human)RGD 
Fth1Rathepatocellular carcinoma  IEP 632698mRNA:increased expression:liver (rat)RGD 
Fth1RatIron Overload  ISOFTH1 (Homo sapiens)737708DNA:snp:5' utr:c.-165T>A (human)RGD 
1 to 13 of 13 rows
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Original Reference(s)
Fth1Ratautosomal dominant vitreoretinochoroidopathy  ISOFTH1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10788642 more ...
Fth1Ratbestrophinopathy  ISOFTH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Autosomal recessive bestrophinopathyClinVarPMID:10788642 more ...
Fth1Ratfundus dystrophy  ISOFTH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Retinal dystrophyClinVarPMID:10394929 more ...
Fth1Ratgenetic disease  ISOFTH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:28492532
Fth1Rathemochromatosis type 5  ISOFTH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hemochromatosis type 5ClinVarPMID:11389486 more ...
Fth1Ratintellectual disability  ISOFTH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
Fth1RatIron Overload  ISOFTH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Iron OverloadClinVarPMID:14615048 more ...
Fth1Ratleukocyte adhesion deficiency 3  ISOFTH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Leukocyte adhesion deficiency 3ClinVarPMID:28492532
Fth1RatNeurodegeneration with Brain Iron Accumulation 9  ISOFTH1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:14615048 more ...
Fth1Ratretinitis pigmentosa  ISOFTH1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:14615048 more ...
Fth1Ratretinitis pigmentosa  ISOFTH1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:14615048 more ...
Fth1Ratretinitis pigmentosa 50  ISOFTH1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10788642 more ...
Fth1RatVitelliform Macular Dystrophy 2  ISOFTH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Vitelliform macular dystrophy 2ClinVarPMID:10394929 more ...
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1 to 9 of 9 rows
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Original Reference(s)
Fth1Ratcontact dermatitis  ISOFTH1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25724174
Fth1Ratdepressive disorder  ISOFTH1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17063146
Fth1Rathigh grade glioma  ISOFTH1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21385903
Fth1RatIron Overload  ISOFTH1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11389486
Fth1RatKeloid  ISOFTH1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20128793
Fth1Ratmalignant mesothelioma  ISOFTH1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26818092
Fth1RatNeoplasm Invasiveness  ISOFTH1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20390345
Fth1Ratneurodegenerative disease  ISOFTH1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15964507
Fth1Ratpre-malignant neoplasm  ISOFTH1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21785164
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Original Reference(s)
Fth1Rathemochromatosis type 5  ISOFTH1 (Homo sapiens)7240710 OMIM 
Fth1RatNeurodegeneration with Brain Iron Accumulation 9  ISOFTH1 (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Fth1Rat(+)-catechin increases expressionISOFTH1 (Homo sapiens)6480464Catechin results in increased expression of FTH1 mRNACTDPMID:15465739
Fth1Rat(-)-alpha-phellandrene increases expressionISOFTH1 (Homo sapiens)6480464alpha phellandrene results in increased expression of FTH1 mRNACTDPMID:25075043
Fth1Rat(1->4)-beta-D-glucan multiple interactionsISOFth1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of FTH1 mRNACTDPMID:36331819
Fth1Rat1,2-dimethylhydrazine multiple interactionsISOFth1 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of FTH1 mRNACTDPMID:22206623
Fth1Rat1,2-dimethylhydrazine decreases expressionISOFth1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of FTH1 mRNACTDPMID:22206623
Fth1Rat1,3-benzothiazole-2-thiol increases expressionISOFTH1 (Homo sapiens)6480464captax results in increased expression of FTH1 mRNACTDPMID:24211530
Fth1Rat1,3-dichloropropan-2-ol decreases expressionISOFTH1 (Homo sapiens)64804641 and 3-dichloro-2-propanol results in decreased expression of FTH1 proteinCTDPMID:35870111
Fth1Rat1,3-dichloropropan-2-ol decreases expressionISOFth1 (Mus musculus)64804641 and 3-dichloro-2-propanol results in decreased expression of FTH1 proteinCTDPMID:35870111
Fth1Rat1,3-dichloropropan-2-ol multiple interactionsISOFTH1 (Homo sapiens)6480464[Thiazoles binds to indoline] promotes the reaction [1 more ...CTDPMID:35870111
Fth1Rat1,4-phenylenediamine increases expressionISOFTH1 (Homo sapiens)64804644-phenylenediamine results in increased expression of FTH1 mRNACTDPMID:16314067
Fth1Rat1-aminobenzotriazole multiple interactionsISOFth1 (Mus musculus)64804641-aminobenzotriazole inhibits the reaction [propylene dichloride results in increased expression of FTH1 protein]CTDPMID:32435916
Fth1Rat1-chloro-2,4-dinitrobenzene increases expressionISOFTH1 (Homo sapiens)6480464Dinitrochlorobenzene results in increased expression of FTH1 mRNACTDPMID:16314067
Fth1Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expressionISOFth1 (Mus musculus)64804641-Methyl-4-phenyl-1 more ...CTDPMID:36435477
Fth1Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactionsISOFth1 (Mus musculus)64804643-Hydroxybutyric Acid inhibits the reaction [1-Methyl-4-phenyl-1 more ...CTDPMID:36435477
Fth1Rat1-naphthyl isothiocyanate multiple interactionsISOFTH1 (Homo sapiens)6480464[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of FTH1 mRNACTDPMID:27344345
Fth1Rat17beta-estradiol decreases expressionISOFTH1 (Homo sapiens)6480464Estradiol results in decreased expression of FTH1 mRNACTDPMID:11179685
Fth1Rat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of FTH1 proteinCTDPMID:32145629
Fth1Rat17beta-estradiol multiple interactionsISOFTH1 (Homo sapiens)6480464Tetrachlorodibenzodioxin promotes the reaction [Estradiol results in decreased expression of FTH1 mRNA]CTDPMID:11179685
Fth1Rat17beta-hydroxy-17-methylestra-4,9,11-trien-3-one decreases expressionISOFTH1 (Homo sapiens)6480464Metribolone results in decreased expression of FTH1 proteinCTDPMID:17152098
Fth1Rat2,2',4,4'-Tetrabromodiphenyl ether multiple interactionsISOFth1 (Mus musculus)6480464[Flame Retardants results in increased abundance of 2 more ...CTDPMID:38995820

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Biological Process
1 to 12 of 12 rows

  
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Original Reference(s)
Fth1Ratimmune response involved_inISSUniProtKB:Q8TD271600115GO_REF:0000024UniProtGO_REF:0000024
Fth1Ratintracellular iron ion homeostasis involved_inIEAUniProtKB-KW:KW-04091600115GO_REF:0000043UniProtGO_REF:0000043
Fth1Ratintracellular iron ion homeostasis involved_inIEAInterPro:IPR0015191600115GO_REF:0000002InterProGO_REF:0000002
Fth1Ratiron ion transport involved_inIEAInterPro:IPR0015191600115GO_REF:0000002InterProGO_REF:0000002
Fth1Ratiron ion transport acts_upstream_of_or_withinISOFth1 (Mus musculus)1624291 PMID:21886823RGDPMID:21886823
Fth1Ratiron ion transport involved_inIBAMGI:95588 and PANTHER:PTN0001531271600115GO_REF:0000033GO_CentralGO_REF:0000033
Fth1Ratnegative regulation of cell population proliferation involved_inISSUniProtKB:Q8TD271600115GO_REF:0000024UniProtGO_REF:0000024
Fth1Ratnegative regulation of cellular process  IMP 2315110cardiomyocyte necrotic deathRGD 
Fth1Ratnegative regulation of ferroptosis involved_inISOFTH1 (Homo sapiens)1624291 PMID:26403645RGDPMID:26403645
Fth1Ratnegative regulation of ferroptosis involved_inISSUniProtKB:P027941600115GO_REF:0000024UniProtGO_REF:0000024
Fth1Ratnegative regulation of fibroblast proliferation involved_inIDA 8554663PMID:9924025UniProt 
Fth1Ratnegative regulation of fibroblast proliferation involved_inISOFTH1 (Homo sapiens)1624291 PMID:9924025RGDPMID:9924025
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Cellular Component
1 to 10 of 10 rows

  
Object Symbol
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Original Reference(s)
Fth1Ratautolysosome located_inISOFTH1 (Homo sapiens)1624291 PMID:25327288RGDPMID:25327288
Fth1Ratautophagosome located_inIEAUniProtKB-SubCell:SL-00231600115GO_REF:0000044UniProtGO_REF:0000044
Fth1Ratcytoplasm is_active_inIBAFB:FBgn0015221 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Fth1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Fth1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Fth1Ratcytoplasmic vesicle located_inIEAUniProtKB-KW:KW-09681600115GO_REF:0000043UniProtGO_REF:0000043
Fth1Ratcytosol is_active_inISOFth1 (Mus musculus)1624291 PMID:29074498RGDPMID:29074498
Fth1Ratlysosome located_inIEAUniProtKB-SubCell:SL-01581600115GO_REF:0000044UniProtGO_REF:0000044
Fth1Ratlysosome located_inIEAUniProtKB-KW:KW-04581600115GO_REF:0000043UniProtGO_REF:0000043
Fth1Ratmembrane is_active_inISOFth1 (Mus musculus)1624291 PMID:29074498RGDPMID:29074498
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Molecular Function
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Original Reference(s)
Fth1Ratferric iron binding enablesIEAInterPro:IPR001519 and InterPro:IPR0083311600115GO_REF:0000002InterProGO_REF:0000002
Fth1Ratferric iron binding enablesIBAPANTHER:PTN000153092 and UniProtKB:P0A9981600115GO_REF:0000033GO_CentralGO_REF:0000033
Fth1Ratferrous iron binding enablesISOFTH1 (Homo sapiens)1624291 PMID:9003196RGDPMID:9003196
Fth1Ratferrous iron binding enablesIBAFB:FBgn0015221 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Fth1Ratferroxidase activity enablesISOFTH1 (Homo sapiens)1624291 PMID:9003196RGDPMID:9003196
Fth1Ratferroxidase activity enablesIEAEC:1.16.3.11600115GO_REF:0000003UniProtGO_REF:0000003
Fth1Ratferroxidase activity enablesIEARHEA:111481600115GO_REF:0000116RHEAGO_REF:0000116
Fth1Ratidentical protein binding enablesISOFTH1 (Homo sapiens)1624291UniProtKB:P02794 more ...RGDPMID:25416956 more ...
Fth1Ratidentical protein binding enablesISOFth1 (Mus musculus)1624291UniProtKB:P09528 more ...RGDPMID:11591653 more ...
Fth1Ratiron ion binding enablesISOFth1 (Mus musculus)1624291 PMID:21886823RGDPMID:21886823
Fth1Ratiron ion sequestering activity enablesISOFTH1 (Homo sapiens)1624291 PMID:9924025RGDPMID:9924025
Fth1Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Fth1Ratoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
Fth1Ratprotein binding  IPICxcr4 (Rattus norvegicus)2315109 RGD 
Fth1Ratprotein binding enablesISOFTH1 (Homo sapiens)1624291UniProtKB:O00560 more ...RGDPMID:15607035 more ...
1 to 15 of 15 rows

RGD Manual Annotations


  
Object Symbol
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Original Reference(s)
Fth1Ratiron storage pathway  ISOFTH1 (Homo sapiens)11556277 RGD 
Fth1Ratiron storage pathway  ISOFTH1 (Homo sapiens)11554199 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
Fth1Ratporphyrin and chlorophyll metabolic pathway  IEA 6907045 KEGGrno:00860

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#
Reference Title
Reference Citation
1. Early embryonic lethality of H ferritin gene deletion in mice. Ferreira C, etal., J Biol Chem 2000 Feb 4;275(5):3021-4.
2. Biology of ferritin in mammals: an update on iron storage, oxidative damage and neurodegeneration. Finazzi D and Arosio P, Arch Toxicol. 2014 Oct;88(10):1787-802. doi: 10.1007/s00204-014-1329-0. Epub 2014 Aug 15.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Using IL-2R/lymphocytes for predicting the clinical progression of patients with COVID-19. Hou H, etal., Clin Exp Immunol. 2020 Jul;201(1):76-84. doi: 10.1111/cei.13450. Epub 2020 May 15.
6. A mutation, in the iron-responsive element of H ferritin mRNA, causing autosomal dominant iron overload. Kato J, etal., Am J Hum Genet 2001 Jul;69(1):191-7. Epub 2001 May 24.
7. A vector-primer-cloner-sequencer plasmid for the construction of cDNA libraries: evidence for a rat glyceraldehyde-3-phosphate dehydrogenase-like mRNA and a ferritin mRNA within testis. Krawetz SA, etal., DNA 1986 Oct;5(5):427-35.
8. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
9. Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Lane DJ, etal., Biochim Biophys Acta. 2015 May;1853(5):1130-44. doi: 10.1016/j.bbamcr.2015.01.021. Epub 2015 Feb 4.
10. Disrupted iron metabolism and ensuing oxidative stress may mediate cognitive dysfunction induced by chronic cerebral hypoperfusion. Li Y, etal., Biol Trace Elem Res. 2012 Dec;150(1-3):242-8. doi: 10.1007/s12011-012-9455-0. Epub 2012 May 26.
11. Conservation of ferritin heavy subunit gene structure: implications for the regulation of ferritin gene expression. Murray MT, etal., Proc Natl Acad Sci U S A 1987 Nov;84(21):7438-42.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. Downregulation of ferritin heavy chain increases labile iron pool, oxidative stress and cell death in cardiomyocytes. Omiya S, etal., J Mol Cell Cardiol. 2009 Jan;46(1):59-66. Epub 2008 Oct 19.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Comprehensive gene review and curation RGD comprehensive gene curation
20. Morphine increases brain levels of ferritin heavy chain leading to inhibition of CXCR4-mediated survival signaling in neurons. Sengupta R, etal., J Neurosci. 2009 Feb 25;29(8):2534-44.
1 to 20 of 25 rows
PMID:6546756   PMID:11872741   PMID:18056970   PMID:18614015   PMID:18835382   PMID:19056867   PMID:21630459   PMID:21886823   PMID:22207220   PMID:22585610   PMID:23376485   PMID:23533145  
PMID:25327288   PMID:26203149   PMID:30046590   PMID:32959272   PMID:37661197  



Fth1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81216,052,037 - 216,054,325 (+)NCBIGRCr8
mRatBN7.21206,627,142 - 206,629,430 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1206,627,103 - 206,725,424 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1215,005,534 - 215,007,822 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,060,660 - 222,062,948 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01214,755,668 - 214,757,956 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01226,030,940 - 226,033,228 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1226,030,938 - 226,033,228 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01232,979,122 - 232,981,410 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41212,430,453 - 212,432,741 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11212,588,882 - 212,591,171 (+)NCBI
Celera1204,122,676 - 204,124,964 (+)NCBICelera
RH 3.4 Map14258.8RGD
Cytogenetic Map1q43NCBI
FTH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,964,285 - 61,967,634 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,959,718 - 61,967,634 (-)EnsemblGRCh38hg38GRCh38
GRCh371161,731,757 - 61,735,106 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361161,488,333 - 61,491,708 (-)NCBINCBI36Build 36hg18NCBI36
Build 341161,488,334 - 61,491,708NCBI
Celera1159,067,058 - 59,070,433 (-)NCBICelera
Cytogenetic Map11q12.3NCBI
HuRef1158,059,745 - 58,063,103 (-)NCBIHuRef
CHM1_11161,614,953 - 61,618,328 (-)NCBICHM1_1
T2T-CHM13v2.01161,953,110 - 61,956,459 (-)NCBIT2T-CHM13v2.0
Fth1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39199,957,964 - 9,962,475 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl199,957,962 - 9,962,462 (+)EnsemblGRCm39 Ensembl
GRCm38199,980,600 - 9,985,111 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl199,980,598 - 9,985,098 (+)EnsemblGRCm38mm10GRCm38
MGSCv371910,057,193 - 10,059,582 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361910,049,748 - 10,052,137 (+)NCBIMGSCv36mm8
Celera1910,680,030 - 10,682,419 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map196.23NCBI
Fth1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555115,771,777 - 5,773,112 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555115,772,374 - 5,773,224 (+)NCBIChiLan1.0ChiLan1.0
FTH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2963,197,979 - 63,203,292 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11164,241,728 - 64,244,902 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01157,329,163 - 57,332,248 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11160,687,517 - 60,690,080 (-)NCBIpanpan1.1PanPan1.1panPan2
FTH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11854,466,167 - 54,468,733 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1854,466,023 - 54,468,732 (+)EnsemblCanFam3.1canFam3CanFam3.1
UMICH_Zoey_3.12832,593,900 - 32,594,536 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02832,618,740 - 32,619,377 (-)NCBIUNSW_CanFamBas_1.0
Fth1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494711,005,083 - 11,006,769 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365811,118,905 - 1,120,592 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FTH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.129,535,051 - 9,537,979 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.228,983,179 - 8,986,091 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FTH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1111,837,533 - 11,840,926 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038109,211,114 - 109,214,623 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fth1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624926469,870 - 471,142 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Fth1
13 total Variants

Predicted Target Of
Summary Value
Count of predictions:123
Count of miRNA genes:101
Interacting mature miRNAs:109
Transcripts:ENSRNOT00000030919
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 88 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat

1 to 10 of 88 rows
RH94403  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map14258.8UniSTS
Cytogenetic Map3q41UniSTS
Cytogenetic Map1q43UniSTS
RH127322  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1q43UniSTS
Cytogenetic Map3q41UniSTS
D1Bda53  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21206,627,248 - 206,627,467 (+)MAPPERmRatBN7.2
Rnor_6.01226,031,047 - 226,031,265NCBIRnor6.0
Rnor_5.01232,979,229 - 232,979,447UniSTSRnor5.0
RGSC_v3.41212,430,560 - 212,430,778UniSTSRGSC3.4
Celera1204,122,783 - 204,123,001UniSTS
Cytogenetic Map1q43UniSTS
BF387442  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21206,629,585 - 206,629,735 (+)MAPPERmRatBN7.2
Rnor_6.01226,033,384 - 226,033,533NCBIRnor6.0
Rnor_5.01232,981,566 - 232,981,715UniSTSRnor5.0
RGSC_v3.41212,432,897 - 212,433,046UniSTSRGSC3.4
Celera1204,125,120 - 204,125,269UniSTS
RH 3.4 Map11520.4UniSTS
Cytogenetic Map1q43UniSTS
RH124242  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21206,629,181 - 206,629,285 (+)MAPPERmRatBN7.2
mRatBN7.2123,638,719 - 23,638,823 (+)MAPPERmRatBN7.2
mRatBN7.23136,915,508 - 136,915,612 (+)MAPPERmRatBN7.2
Rnor_6.01226,032,980 - 226,033,083NCBIRnor6.0
Rnor_6.0125,077,959 - 25,078,062NCBIRnor6.0
Rnor_5.01232,981,162 - 232,981,265UniSTSRnor5.0
Rnor_5.0126,536,032 - 26,536,135UniSTSRnor5.0
RGSC_v3.41212,432,493 - 212,432,596UniSTSRGSC3.4
RGSC_v3.4124,186,378 - 24,186,481UniSTSRGSC3.4
Celera122,350,730 - 22,350,833UniSTS
Celera1204,124,716 - 204,124,819UniSTS
Cytogenetic Map1q43UniSTS
Cytogenetic Map1p12UniSTS




alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 38 94 64 60 48 6 48 6 144 56 82 34 49 12


1 to 30 of 250 rows
RefSeq Transcripts NM_012848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH002171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC060581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC089817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC097341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC111078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC127507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 250 rows

Ensembl Acc Id: ENSRNOT00000030919   ⟹   ENSRNOP00000037803
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1206,627,106 - 206,725,424 (+)Ensembl
Rnor_6.0 Ensembl1226,030,938 - 226,033,228 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094152   ⟹   ENSRNOP00000087821
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1206,627,103 - 206,629,048 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119519   ⟹   ENSRNOP00000079245
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1206,627,108 - 206,629,429 (+)Ensembl
RefSeq Acc Id: NM_012848   ⟹   NP_036980
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,052,037 - 216,054,325 (+)NCBI
mRatBN7.21206,627,142 - 206,629,430 (+)NCBI
Rnor_6.01226,030,940 - 226,033,228 (+)NCBI
Rnor_5.01232,979,122 - 232,981,410 (+)NCBI
RGSC_v3.41212,430,453 - 212,432,741 (+)RGD
Celera1204,122,676 - 204,124,964 (+)RGD
Sequence:
RefSeq Acc Id: NP_036980   ⟸   NM_012848
- UniProtKB: P19132 (UniProtKB/Swiss-Prot),   Q66HI5 (UniProtKB/TrEMBL),   F7F0Q6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000037803   ⟸   ENSRNOT00000030919
Ensembl Acc Id: ENSRNOP00000079245   ⟸   ENSRNOT00000119519
Ensembl Acc Id: ENSRNOP00000087821   ⟸   ENSRNOT00000094152
Ferritin-like diiron

Name Modeler Protein Id AA Range Protein Structure
AF-P19132-F1-model_v2 AlphaFold P19132 1-182 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690762
Promoter ID:EPDNEW_R1287
Type:multiple initiation site
Name:Fth1_1
Description:ferritin heavy chain 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01226,030,901 - 226,030,961EPDNEW


1 to 40 of 48 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-56447 BioCyc
Ensembl Genes ENSRNOG00000022619 Ensembl
  ENSRNOG00000076813 ENTREZGENE
Ensembl Transcript ENSRNOT00000136566 ENTREZGENE
Gene3D-CATH 1.20.1260.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6922002 IMAGE-MGC_LOAD
  IMAGE:7124353 IMAGE-MGC_LOAD
  IMAGE:7189574 IMAGE-MGC_LOAD
  IMAGE:7191119 IMAGE-MGC_LOAD
  IMAGE:7387633 IMAGE-MGC_LOAD
  IMAGE:7445527 IMAGE-MGC_LOAD
  IMAGE:7446591 IMAGE-MGC_LOAD
InterPro Ferritin UniProtKB/Swiss-Prot
  Ferritin-like UniProtKB/Swiss-Prot
  Ferritin-like_diiron UniProtKB/Swiss-Prot
  Ferritin-like_SF UniProtKB/Swiss-Prot
  Ferritin_CS UniProtKB/Swiss-Prot
  Ferritin_DPS_dom UniProtKB/Swiss-Prot
KEGG Report rno:25319 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108755 IMAGE-MGC_LOAD
  MGC:114352 IMAGE-MGC_LOAD
  MGC:125269 IMAGE-MGC_LOAD
  MGC:156674 IMAGE-MGC_LOAD
  MGC:72918 IMAGE-MGC_LOAD
  MGC:93615 IMAGE-MGC_LOAD
  MGC:93616 IMAGE-MGC_LOAD
NCBI Gene 25319 ENTREZGENE
PANTHER FERRITIN HEAVY CHAIN UniProtKB/Swiss-Prot
  PTHR11431 UniProtKB/Swiss-Prot
Pfam Ferritin UniProtKB/Swiss-Prot
PharmGKB FTH1 RGD
PhenoGen Fth1 PhenoGen
PROSITE FERRITIN_1 UniProtKB/Swiss-Prot
  FERRITIN_2 UniProtKB/Swiss-Prot
  FERRITIN_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000022619 RatGTEx
  ENSRNOG00000076813 RatGTEx
Superfamily-SCOP SSF47240 UniProtKB/Swiss-Prot
UniProt A0A8I5ZMC0_RAT UniProtKB/TrEMBL
  A0A8I6A564_RAT UniProtKB/TrEMBL
1 to 40 of 48 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-01 Fth1  ferritin heavy chain 1  Fth1  ferritin, heavy polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Fth1  ferritin, heavy polypeptide 1  Fth1  ferritin heavy chain 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Fth1  ferritin heavy chain 1  Fth1  ferritin, heavy polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Fth1  ferritin, heavy polypeptide 1    Ferritin subunit H  Name updated 625702 APPROVED
2002-06-10 Fth1  Ferritin subunit H      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_expression overexpressed in rat hepatocellular carcinoma after being induced by diethylnitrosamine, overexpression related to the initiation and progression of tumors 632698
gene_homology 88% similar to human ferritin-H cDNA 632698