Fosl1 (FOS like 1, AP-1 transcription factor subunit) - Rat Genome Database

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Gene: Fosl1 (FOS like 1, AP-1 transcription factor subunit) Rattus norvegicus
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Symbol: Fosl1
Name: FOS like 1, AP-1 transcription factor subunit
RGD ID: 2627
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including regulation of DNA-templated transcription; response to corticosterone; and response to progesterone. Located in presynaptic membrane. Biomarker of congestive heart failure and renal carcinoma. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human FOSL1 (FOS like 1, AP-1 transcription factor subunit); PARTICIPATES IN Wnt signaling pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: FOS like 1, AP-1 trancription factor subunit; fos-like antigen 1; fos-related antigen 1; Fra-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81212,183,885 - 212,192,391 (+)NCBIGRCr8
mRatBN7.21202,754,549 - 202,763,057 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1202,754,529 - 202,764,930 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1211,106,898 - 211,115,363 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,199,949 - 218,208,463 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01210,890,991 - 210,899,504 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01220,826,560 - 220,835,066 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1220,826,560 - 220,835,066 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01227,755,887 - 227,764,393 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41208,090,612 - 208,099,118 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11208,244,064 - 208,252,571 (+)NCBI
Celera1200,290,637 - 200,299,144 (+)NCBICelera
Cytogenetic Map1q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 12 of 12 rows

  
Object Symbol
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Original Reference(s)
Fosl1RatBreast Neoplasms  ISOFOSL1 (Homo sapiens)2293756mRNA and protein:increased expression:breastRGD 
Fosl1Ratcervical squamous cell carcinoma  ISOFOSL1 (Homo sapiens)2293757protein:decreased expression:uterine cervixRGD 
Fosl1Ratcolon adenocarcinoma  ISOFOSL1 (Homo sapiens)153344572protein:increased expression:colon (human)RGD 
Fosl1Ratcongestive heart failure  IEP 2293777 RGD 
Fosl1Ratductal carcinoma in situ  ISOFOSL1 (Homo sapiens)2293756mRNA and protein:increased expression:breastRGD 
Fosl1RatExperimental Seizures treatmentIEP 2293787protein:increased expression:hippocampusRGD 
Fosl1RatFibroadenoma  ISOFOSL1 (Homo sapiens)2293756mRNA and protein:increased expression:breastRGD 
Fosl1Ratosteopetrosis  ISOFosl1 (Mus musculus)737712 RGD 
Fosl1Ratrenal carcinoma  IEP 2293758mRNA:increased expression:kidneyRGD 
Fosl1RatReperfusion Injury  IEP 1642465mRNA:increased expression:hippocampusRGD 
Fosl1Ratstomach cancer  ISOFOSL1 (Homo sapiens)153344570DNA:SNP:5' utr (human)RGD 
Fosl1Rattongue squamous cell carcinoma  ISOFOSL1 (Homo sapiens)11535375protein:decreased expression:tongue (human)RGD 
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Original Reference(s)
Fosl1RatAicardi-Goutieres Syndrome 3  ISOFOSL1 (Homo sapiens)8554872ClinVar Annotator: match by term: Aicardi-Goutieres syndrome 3ClinVarPMID:28492532
Fosl1Ratautosomal recessive cutis laxa type IB  ISOFOSL1 (Homo sapiens)8554872ClinVar Annotator: match by term: Cutis laxa more ...ClinVarPMID:28492532
Fosl1RatBardet-Biedl syndrome  ISOFOSL1 (Homo sapiens)8554872ClinVar Annotator: match by term: Bardet-Biedl syndromeClinVarPMID:12118255 more ...
Fosl1Ratglycogen storage disease V  ISOFOSL1 (Homo sapiens)8554872ClinVar Annotator: match by term: Glycogen storage disease and type VClinVarPMID:12118255 more ...
Fosl1Ratimmunodeficiency 90  ISOFOSL1 (Homo sapiens)8554872ClinVar Annotator: match by term: Infections more ...ClinVarPMID:28492532
Fosl1Ratintellectual disability  ISOFOSL1 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 

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Original Reference(s)
Fosl1Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of FOSL1 mRNA]CTDPMID:31150632
Fosl1Rat(1->4)-beta-D-glucan multiple interactionsISOFosl1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of FOSL1 mRNACTDPMID:36331819
Fosl1Rat(2E,4E)-hexa-2,4-dienoic acid increases expressionISOFosl1 (Mus musculus)6480464Sorbic Acid results in increased expression of FOSL1 proteinCTDPMID:20025956
Fosl1Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expressionISOFOSL1 (Homo sapiens)6480464o and p'-DDT results in increased expression of FOSL1 mRNACTDPMID:22609851
Fosl1Rat1,2,4-trimethylbenzene increases expressionEXP 6480464pseudocumene results in increased expression of FOSL1 proteinCTDPMID:17337753
Fosl1Rat1,2-dimethylhydrazine increases expressionEXP 64804641 and 2-Dimethylhydrazine results in increased expression of FOSL1 mRNACTDPMID:27840820
Fosl1Rat1,2-dimethylhydrazine increases expressionISOFosl1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of FOSL1 mRNACTDPMID:22206623
Fosl1Rat1-chloro-2,4-dinitrobenzene increases expressionISOFOSL1 (Homo sapiens)6480464Dinitrochlorobenzene results in increased expression of FOSL1 mRNACTDPMID:25236440
Fosl1Rat17alpha-ethynylestradiol multiple interactionsEXP 6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FOSL1 proteinCTDPMID:8625438
Fosl1Rat17alpha-ethynylestradiol multiple interactionsISOFosl1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FOSL1 mRNACTDPMID:17942748
Fosl1Rat17alpha-ethynylestradiol affects expressionISOFosl1 (Mus musculus)6480464Ethinyl Estradiol affects the expression of FOSL1 mRNACTDPMID:17555576
Fosl1Rat17alpha-ethynylestradiol increases expressionISOFosl1 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of FOSL1 mRNACTDPMID:17942748
Fosl1Rat17alpha-ethynylestradiol affects expressionISOFOSL1 (Homo sapiens)6480464Ethinyl Estradiol affects the expression of FOSL1 mRNACTDPMID:20170705
Fosl1Rat17beta-estradiol increases expressionISOFosl1 (Mus musculus)6480464Estradiol results in increased expression of FOSL1 mRNA and Estradiol results in increased expression of FOSL1 proteinCTDPMID:20025956 and PMID:25210133
Fosl1Rat17beta-estradiol increases expressionISOFOSL1 (Homo sapiens)6480464Estradiol results in increased expression of FOSL1 mRNACTDPMID:20106945 more ...
Fosl1Rat17beta-estradiol multiple interactionsISOFOSL1 (Homo sapiens)6480464[Estradiol co-treated with EGF protein] results in increased expression of FOSL1 mRNACTDPMID:24758408
Fosl1Rat17beta-hydroxy-5alpha-androstan-3-one increases expressionISOFosl1 (Mus musculus)6480464Dihydrotestosterone results in increased expression of FOSL1 proteinCTDPMID:20025956
Fosl1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOFOSL1 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of FOSL1 mRNACTDPMID:12377990 more ...
Fosl1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of FOSL1 mRNACTDPMID:33387578
Fosl1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOFOSL1 (Homo sapiens)64804642-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FOSL1 mRNA]CTDPMID:23625689

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Biological Process
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Original Reference(s)
Fosl1Ratcytokine-mediated signaling pathway acts_upstream_of_or_withinISOFosl1 (Mus musculus)1624291MGI:3055991 PMID:30990796RGDPMID:30990796
Fosl1Ratfemale pregnancy  IEP 2293785 RGD 
Fosl1Ratgene expression acts_upstream_of_or_withinISOFosl1 (Mus musculus)1624291MGI:3055991 PMID:30990796RGDPMID:30990796
Fosl1Ratin utero embryonic development acts_upstream_of_or_withinISOFosl1 (Mus musculus)1624291MGI:2385824 PMID:11044407RGDPMID:11044407
Fosl1Ratinflammatory response acts_upstream_of_or_withinISOFosl1 (Mus musculus)1624291MGI:3055991 PMID:30990796RGDPMID:30990796
Fosl1Ratlearning  IEP 2293771 RGD 
Fosl1Ratnegative regulation of cell population proliferation  IMP 2293781 RGD 
Fosl1Ratplacenta blood vessel development acts_upstream_of_or_withinISOFosl1 (Mus musculus)1624291MGI:2385824 PMID:11044407RGDPMID:11044407
Fosl1Ratpositive regulation of apoptotic process  IMP 2293781 RGD 
Fosl1Ratpositive regulation of cell cycle  IMP 2293764 RGD 
Fosl1Ratpositive regulation of DNA-binding transcription factor activity  IDA 629541 RGD 
Fosl1Ratpositive regulation of DNA-templated transcription initiation involved_inISOFOSL1 (Homo sapiens)1624291 PMID:23027619RGDPMID:23027619
Fosl1Ratpositive regulation of miRNA transcription involved_inISOFOSL1 (Homo sapiens)1624291 PMID:21673316RGDPMID:21673316
Fosl1Ratpositive regulation of transcription by RNA polymerase II involved_inIDA 629541PMID:12371906NTNU_SB 
Fosl1Ratregulation of DNA-templated transcription involved_inIEAInterPro:IPR004827 and InterPro:IPR0463471600115GO_REF:0000002InterProGO_REF:0000002
Fosl1Ratregulation of transcription by RNA polymerase II involved_inIEAInterPro:IPR0008371600115GO_REF:0000002InterProGO_REF:0000002
Fosl1Ratregulation of transcription by RNA polymerase II involved_inIBAFB:FBgn0001297 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Fosl1Ratresponse to cAMP  IEP 2293796 RGD 
Fosl1Ratresponse to corticosterone  IEP 2293759 RGD 
Fosl1Ratresponse to cytokine  IEP 2293782 RGD 
1 to 20 of 29 rows

Cellular Component

  
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Original Reference(s)
Fosl1Ratnucleoplasm located_inTAS 1600115Reactome:R-RNO-9620373ReactomeReactome:R-RNO-9620373
Fosl1Ratnucleoplasm located_inISOFOSL1 (Homo sapiens) and UniProtKB:P15407-11624291 RGDGO_REF:0000052
Fosl1Ratnucleus is_active_inIBAFB:FBgn0001297 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Fosl1Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Fosl1Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Fosl1Ratpresynaptic membrane  IDA 2293797 RGD 
Fosl1RatRNA polymerase II transcription regulator complex part_ofISOFOSL1 (Homo sapiens)1624291 PMID:23661758 and PMID:28186491RGDPMID:23661758 and PMID:28186491

Molecular Function
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Fosl1RatDNA binding enablesIEAInterPro:IPR0008371600115GO_REF:0000002InterProGO_REF:0000002
Fosl1RatDNA binding  IDA 629541 RGD 
Fosl1RatDNA binding enablesIEAUniProtKB-KW:KW-02381600115GO_REF:0000043UniProtGO_REF:0000043
Fosl1RatDNA binding enablesIEAARBA:ARBA000292241600115GO_REF:0000117UniProtGO_REF:0000117
Fosl1RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesIDA 629541PMID:12371906NTNU_SB 
Fosl1RatDNA-binding transcription factor activity enablesIEAInterPro:IPR000837 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Fosl1RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIBAFB:FBgn0001297 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Fosl1Ratpromoter-specific chromatin binding enablesISOFosl1 (Mus musculus)1624291 PMID:30990796RGDPMID:30990796
Fosl1Ratprotein binding enablesISOFOSL1 (Homo sapiens)1624291UniProtKB:O60333-2 more ...RGDPMID:16189514 more ...
Fosl1RatRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesIDA 629541PMID:12371906NTNU_SB 
Fosl1RatRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesIBAFB:FBgn0001297 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Fosl1RatRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesISOFOSL1 (Homo sapiens)1624291 PMID:21673316RGDPMID:21673316
Fosl1RatRNA polymerase II transcription regulatory region sequence-specific DNA binding enablesISOFosl1 (Mus musculus)1624291 PMID:19289495RGDPMID:19289495
Fosl1Ratsequence-specific double-stranded DNA binding enablesISOFOSL1 (Homo sapiens)1624291 PMID:28473536RGDPMID:28473536
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Imported Annotations - KEGG (archival)

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Original Reference(s)
Fosl1RatWnt signaling pathway  IEA 6907045 KEGGrno:04310

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#
Reference Title
Reference Citation
1. Insidious role of nitric oxide in migration/invasion of colon cancer cells by upregulating MMP-2/9 via activation of cGMP-PKG-ERK signaling pathways. Babykutty S, etal., Clin Exp Metastasis. 2012 Jun;29(5):471-92. doi: 10.1007/s10585-012-9464-6. Epub 2012 Mar 15.
2. A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers. Bergman MR, etal., Biochem J 2003 Feb 1;369(Pt 3):485-96.
3. Fra-1 promotes growth and survival in RAS-transformed thyroid cells by controlling cyclin A transcription. Casalino L, etal., EMBO J. 2007 Apr 4;26(7):1878-90. Epub 2007 Mar 8.
4. FRA-1 protein overexpression is a feature of hyperplastic and neoplastic breast disorders. Chiappetta G, etal., BMC Cancer. 2007 Jan 25;7:17.
5. fra-1: a serum-inducible, cellular immediate-early gene that encodes a fos-related antigen. Cohen DR and Curran T, Mol Cell Biol 1988 May;8(5):2063-9.
6. Learning-dependent activation of Fra-1: involvement of ventral hippocampus and SNc/VTA complex in learning and habit formation. Faure A, etal., Brain Res Bull. 2006 Jan 15;68(4):233-48. Epub 2005 Sep 19.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Selective participation of c-Jun with Fra-2/c-Fos promotes aggressive tumor phenotypes and poor prognosis in tongue cancer. Gupta S, etal., Sci Rep. 2015 Nov 19;5:16811. doi: 10.1038/srep16811.
10. Time-course of immediate early gene expression in hippocampal subregions of adrenalectomized rats after acute corticosterone challenge. Hansson AC and Fuxe K, Brain Res. 2008 Jun 18;1215:1-10. Epub 2008 Apr 10.
11. H(2)O(2)-induced egr-1, fra-1, and c-jun gene expression is mediated by tyrosine kinase in aortic smooth muscle cells. Jin N, etal., Free Radic Biol Med. 2000 Oct 15;29(8):736-46.
12. Carbetapentane attenuates kainate-induced seizures via sigma-1 receptor modulation. Kim HC, etal., Life Sci. 2001 Jul 13;69(8):915-22.
13. The regulation of inducible nitric oxide synthase gene expression induced by lipopolysaccharide and tumor necrosis factor-alpha in C6 cells: involvement of AP-1 and NFkappaB. Lee JK, etal., Life Sci. 2003 Jun 20;73(5):595-609.
14. A functional SNP rs1892901 in FOSL1 is associated with gastric cancer in Chinese population. Liu W, etal., Sci Rep. 2017 Feb 7;7:41737. doi: 10.1038/srep41737.
15. Fosl1 is a transcriptional target of c-Fos during osteoclast differentiation. Matsuo K, etal., Nat Genet 2000 Feb;24(2):184-7.
16. Differential expression of activator protein-1 transcription factors in pregnant rat myometrium. Mitchell JA and Lye SJ, Biol Reprod. 2002 Jul;67(1):240-6.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Localization of transcription factor AP-1 family proteins in ameloblast nuclei of the rat incisor. Nishikawa S J Histochem Cytochem. 2000 Nov;48(11):1511-20.
19. Fos- and Jun-related transcription factors are involved in the signal transduction pathway of mechanical loading in condylar chondrocytes. Papachristou D, etal., Eur J Orthod. 2006 Feb;28(1):20-6. Epub 2005 Dec 22.
20. Experience-dependent decrease in synaptically localized Fra-1. Paratcha G, etal., Brain Res Mol Brain Res. 2000 May 31;78(1-2):120-30.
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PMID:7791782   PMID:9294610   PMID:11044407   PMID:12477932   PMID:12773579   PMID:12839939   PMID:19289495   PMID:20472895   PMID:21673316   PMID:21820506   PMID:21947281   PMID:23027619  
PMID:26149388   PMID:30892941   PMID:34973528   PMID:36634215   PMID:37949219  



Fosl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81212,183,885 - 212,192,391 (+)NCBIGRCr8
mRatBN7.21202,754,549 - 202,763,057 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1202,754,529 - 202,764,930 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1211,106,898 - 211,115,363 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,199,949 - 218,208,463 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01210,890,991 - 210,899,504 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01220,826,560 - 220,835,066 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1220,826,560 - 220,835,066 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01227,755,887 - 227,764,393 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41208,090,612 - 208,099,118 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11208,244,064 - 208,252,571 (+)NCBI
Celera1200,290,637 - 200,299,144 (+)NCBICelera
Cytogenetic Map1q43NCBI
FOSL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381165,892,049 - 65,900,545 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1165,892,049 - 65,900,573 (-)EnsemblGRCh38hg38GRCh38
GRCh371165,659,520 - 65,668,016 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361165,416,268 - 65,424,573 (-)NCBINCBI36Build 36hg18NCBI36
Build 341165,416,267 - 65,424,573NCBI
Celera1162,983,599 - 62,991,910 (-)NCBICelera
Cytogenetic Map11q13.1NCBI
HuRef1161,986,283 - 61,994,593 (-)NCBIHuRef
CHM1_11165,544,106 - 65,552,418 (-)NCBICHM1_1
T2T-CHM13v2.01165,885,111 - 65,893,612 (-)NCBIT2T-CHM13v2.0
Fosl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39195,497,726 - 5,505,966 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl195,497,575 - 5,505,974 (+)EnsemblGRCm39 Ensembl
GRCm38195,447,698 - 5,455,938 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl195,447,547 - 5,455,946 (+)EnsemblGRCm38mm10GRCm38
MGSCv37195,447,698 - 5,455,938 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36195,447,698 - 5,455,938 (+)NCBIMGSCv36mm8
Celera195,319,672 - 5,327,911 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map194.33NCBI
Fosl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542219,423,591 - 19,433,885 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542219,425,741 - 19,431,801 (+)NCBIChiLan1.0ChiLan1.0
FOSL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2967,120,758 - 67,129,158 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11168,163,562 - 68,172,119 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01161,252,513 - 61,261,032 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11164,581,841 - 64,589,300 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1164,581,841 - 64,589,304 (-)Ensemblpanpan1.1panPan2
FOSL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11851,366,719 - 51,374,411 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1851,368,352 - 51,373,748 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1849,975,212 - 49,982,921 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01852,404,801 - 52,412,502 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1852,405,480 - 52,411,838 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11851,504,866 - 51,512,571 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01851,079,242 - 51,086,930 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01851,868,548 - 51,876,244 (+)NCBIUU_Cfam_GSD_1.0
Fosl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049477,199,963 - 7,206,564 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365993,642,504 - 3,648,417 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365993,642,504 - 3,649,294 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOSL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl26,430,153 - 6,436,173 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.126,430,158 - 6,436,173 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.225,534,085 - 5,540,201 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FOSL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.118,356,263 - 8,365,606 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl18,356,836 - 8,364,918 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038105,645,101 - 105,654,787 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fosl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476720,519,313 - 20,524,554 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476720,519,054 - 20,525,311 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Fosl1
29 total Variants

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:55
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000027891
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 85 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat

1 to 10 of 85 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 37 91 75 74 43 25 43 6 180 84 71 36 58 31



Ensembl Acc Id: ENSRNOT00000027891   ⟹   ENSRNOP00000027891
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1202,754,529 - 202,764,930 (+)Ensembl
Rnor_6.0 Ensembl1220,826,560 - 220,835,066 (+)Ensembl
RefSeq Acc Id: NM_012953   ⟹   NP_037085
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81212,183,885 - 212,192,391 (+)NCBI
mRatBN7.21202,754,549 - 202,763,057 (+)NCBI
Rnor_6.01220,826,560 - 220,835,066 (+)NCBI
Rnor_5.01227,755,887 - 227,764,393 (+)NCBI
RGSC_v3.41208,090,612 - 208,099,118 (+)RGD
Celera1200,290,637 - 200,299,144 (+)RGD
Sequence:
Protein RefSeqs NP_037085 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41171 (Get FASTA)   NCBI Sequence Viewer  
  AAA82045 (Get FASTA)   NCBI Sequence Viewer  
  AAH97342 (Get FASTA)   NCBI Sequence Viewer  
  EDM12489 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000027891.1
  ENSRNOP00000108693
GenBank Protein P10158 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037085   ⟸   NM_012953
- UniProtKB: Q4V8K7 (UniProtKB/Swiss-Prot),   P10158 (UniProtKB/Swiss-Prot),   A6HZ58 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027891   ⟸   ENSRNOT00000027891
bZIP

Name Modeler Protein Id AA Range Protein Structure
AF-P10158-F1-model_v2 AlphaFold P10158 1-275 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690655
Promoter ID:EPDNEW_R1180
Type:multiple initiation site
Name:Fosl1_2
Description:FOS like 1, AP-1 transcription factor subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1181  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01220,826,536 - 220,826,596EPDNEW
RGD ID:13690656
Promoter ID:EPDNEW_R1181
Type:single initiation site
Name:Fosl1_1
Description:FOS like 1, AP-1 transcription factor subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1180  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01220,826,731 - 220,826,791EPDNEW


1 to 28 of 28 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-56681 BioCyc
Ensembl Genes ENSRNOG00000020552 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000072086 ENTREZGENE
Ensembl Transcript ENSRNOT00000027891.3 UniProtKB/Swiss-Prot
  ENSRNOT00000136311 ENTREZGENE
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7459558 IMAGE-MGC_LOAD
InterPro AP-1 UniProtKB/Swiss-Prot
  bZIP UniProtKB/Swiss-Prot
  bZIP_sf UniProtKB/Swiss-Prot
KEGG Report rno:25445 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114353 IMAGE-MGC_LOAD
NCBI Gene 25445 ENTREZGENE
PANTHER PTHR23351 UniProtKB/Swiss-Prot
  PTHR23351:SF6 UniProtKB/Swiss-Prot
Pfam bZIP_1 UniProtKB/Swiss-Prot
PhenoGen Fosl1 PhenoGen
PRINTS LEUZIPPRFOS UniProtKB/Swiss-Prot
PROSITE BZIP UniProtKB/Swiss-Prot
  BZIP_BASIC UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020552 RatGTEx
  ENSRNOG00000072086 RatGTEx
SMART BRLZ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57959 UniProtKB/Swiss-Prot
UniProt A6HZ58 ENTREZGENE, UniProtKB/TrEMBL
  FOSL1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4V8K7 ENTREZGENE
UniProt Secondary Q4V8K7 UniProtKB/Swiss-Prot
1 to 28 of 28 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-01 Fosl1  FOS like 1, AP-1 transcription factor subunit  Fosl1  FOS like 1, AP-1 trancription factor subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-05-11 Fosl1  FOS like 1, AP-1 trancription factor subunit  Fosl1  fos-like antigen 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Fosl1  Fos-like antigen 1      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_expression mRNA expressed in serum stimulated fibroblasts 632677
gene_homology amino acid homologous to the Fos gene 632677
gene_regulation exhibits immediate-early transcriptional response to extracellular stimuli 632677