Fos (Fos proto-oncogene, AP-1 transcription factor subunit) - Rat Genome Database

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Gene: Fos (Fos proto-oncogene, AP-1 transcription factor subunit) Rattus norvegicus
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Symbol: Fos
Name: Fos proto-oncogene, AP-1 transcription factor subunit
RGD ID: 2626
Description: Enables DNA binding activity; DNA-binding transcription factor activity; and promoter-specific chromatin binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; learning or memory; and nervous system development. Located in endoplasmic reticulum; nuclear matrix; and nucleoplasm. Used to study alcohol dependence; alcohol use disorder; gastric ulcer; and morphine dependence. Biomarker of several diseases, including alcohol dependence; alcohol use disorder; artery disease (multiple); brain disease (multiple); and drug dependence (multiple). Orthologous to human FOS (Fos proto-oncogene, AP-1 transcription factor subunit); PARTICIPATES IN endothelin signaling pathway; fibroblast growth factor signaling pathway; forkhead class A signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-taxifolin; (+)-Tetrandrine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: c-fos; c-fos oncogene; cellular oncogene fos; FBJ murine osteosarcoma viral (v-fos) oncogene homolog; FBJ murine osteosarcoma viral oncogene homolog; FBJ osteosarcoma oncogene; proto-oncogene c-FOS; proto-oncogene cFOS; v-fos FBJ murine osteosarcoma viral oncogene homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86110,852,188 - 110,855,054 (+)NCBIGRCr8
mRatBN7.26105,121,170 - 105,124,036 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6105,121,170 - 105,124,036 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6105,290,640 - 105,293,508 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06105,589,531 - 105,592,399 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06104,959,176 - 104,962,044 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06109,300,433 - 109,303,299 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6109,300,433 - 109,303,299 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06116,249,742 - 116,252,608 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46109,559,135 - 109,562,001 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16109,562,609 - 109,566,002 (+)NCBI
Celera6102,942,464 - 102,945,330 (+)NCBICelera
Cytogenetic Map6q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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FosRatAberrant Crypt Foci treatmentIDA 13432056 RGD 
FosRatAberrant Crypt Foci  IEP 13210754mRNA more ...RGD 
FosRatacute myocardial infarction treatmentIEP 405650598 RGD 
FosRatalcohol dependence treatmentIEP 405295497 RGD 
FosRatalcohol dependence  IEP 405101697protein:increased expression:granular insular cortex more ...RGD 
FosRatalcohol dependence treatmentIDA 405100722 RGD 
FosRatalcohol dependence  IEP 405100958 RGD 
FosRatalcohol use disorder treatmentIDA 405295495 RGD 
FosRatalcohol use disorder  ISOFos (Mus musculus)405255652protein:increased expression:parvocellular oculomotor nucleus RGD 
FosRatalcohol use disorder  IEP 405255650protein:increased expression:brainRGD 
FosRatalcohol withdrawal syndrome treatmentIEP 405255665 RGD 
FosRatalcohol withdrawal syndrome  IEP 405101372protein:altered expression:brainRGD 
FosRatAlcohol-Related Disorders  IEP 405101375protein:increased expression:liverRGD 
FosRatAlcoholic Intoxication  IEP 405255666mRNA:decreased expression:adrenal glandRGD 
FosRatAlcoholic Intoxication  IEP 405101372protein:altered expression:brainRGD 
FosRatamphetamine abuse  ISOFos (Mus musculus)405100720mRNA:increased expression:nucleus accumbensRGD 
FosRatamphetamine abuse  IEP 405255667protein:increased expression:nucleus accumbens and striatumRGD 
FosRatautosomal dominant polycystic kidney disease  ISOFOS (Homo sapiens)7242198protein: increased expression: kidneyRGD 
FosRatBinge Drinking  IEP 405295494protein:increased expression:prefrontal cortexRGD 
FosRatBrain Hypoxia-Ischemia  IEP 405650622protein:decreased expression:hippocampusRGD 
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FosRatintellectual disability  ISOFOS (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disability and mildClinVar 
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FosRatamphetamine abuse  ISOFOS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19689456
FosRatamyotrophic lateral sclerosis type 1  ISOFOS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11796754
FosRatAnimal Disease Models  ISOFOS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27093858
FosRatanxiety disorder  ISOFOS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16488545
FosRatBrain Injuries  ISOFOS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9630518
FosRatBreast Neoplasms  ISOFOS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16298037
FosRatCocaine-Related Disorders  ISOFOS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17276011 more ...
FosRatendometriosis  ISOFOS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23284138
FosRatepilepsy  ISOFOS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15973680
FosRatExperimental Liver Cirrhosis  ISOFOS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25380136
FosRatextrahepatic cholestasis  ISOFOS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28789951
FosRatFibrous Dysplasia of Bone  ISOFOS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:7739708
FosRatHeat Stroke  ISOFOS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24039931
FosRatHemorrhage  ISOFOS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:7844257
FosRathepatocellular carcinoma  ISOFOS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9029167 and PMID:28284560
FosRatHyperalgesia  ISOFOS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27093858
FosRatHyperkinesis  ISOFOS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18355967
FosRathypertension  ISOFOS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12044476 and PMID:24039778
FosRatjuvenile rheumatoid arthritis  ISOFOS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19565504
FosRatLung Neoplasms  ISOFOS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16289808
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FosRat(+)-catechin decreases expressionISOFOS (Homo sapiens)6480464Catechin results in decreased expression of FOS mRNACTDPMID:23706674
FosRat(+)-pilocarpine multiple interactionsEXP 6480464[Pilocarpine co-treated with 2 more ...CTDPMID:7968354 more ...
FosRat(+)-pilocarpine decreases expressionEXP 6480464Pilocarpine results in decreased expression of FOS mRNACTDPMID:17971868
FosRat(+)-pilocarpine increases expressionEXP 6480464Pilocarpine results in increased expression of FOS mRNA and Pilocarpine results in increased expression of FOS proteinCTDPMID:17971868 more ...
FosRat(+)-Pimaric acid multiple interactionsISOFOS (Homo sapiens)6480464pimaric acid inhibits the reaction [JUN protein results in increased expression of FOS protein modified form] and pimaric acid inhibits the reaction [TNF protein results in increased expression of FOS protein]CTDPMID:22705379
FosRat(+)-taxifolin multiple interactionsEXP 6480464taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of FOS protein]CTDPMID:32828744
FosRat(+)-Tetrandrine multiple interactionsEXP 6480464tetrandrine inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA]CTDPMID:10072926
FosRat(-)-alpha-phellandrene increases expressionISOFOS (Homo sapiens)6480464alpha phellandrene results in increased expression of FOS mRNACTDPMID:25075043
FosRat(-)-anisomycin increases expressionISOFOS (Homo sapiens)6480464Anisomycin results in increased expression of FOS mRNACTDPMID:12660819 and PMID:18241849
FosRat(-)-citrinin increases expressionISOFOS (Homo sapiens)6480464Citrinin results in increased expression of FOS mRNA and Citrinin results in increased expression of FOS proteinCTDPMID:19361540
FosRat(-)-citrinin multiple interactionsISOFOS (Homo sapiens)6480464U 0126 inhibits the reaction [Citrinin results in increased expression of FOS protein]CTDPMID:19361540
FosRat(-)-demecolcine increases expressionISOFOS (Homo sapiens)6480464Demecolcine results in increased expression of FOS mRNACTDPMID:23649840
FosRat(-)-ephedrine increases expressionISOFOS (Homo sapiens)6480464Ephedrine results in increased expression of FOS mRNACTDPMID:12730611
FosRat(-)-epigallocatechin 3-gallate decreases activityISOFOS (Homo sapiens)6480464epigallocatechin gallate results in decreased activity of FOS proteinCTDPMID:12663506
FosRat(-)-epigallocatechin 3-gallate multiple interactionsISOFOS (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of FOS mRNACTDPMID:22079256
FosRat(-)-selegiline multiple interactionsISOFOS (Homo sapiens)6480464Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of FOS mRNA]CTDPMID:14724376
FosRat(20R)-protopanaxadiol multiple interactionsISOFos (Mus musculus)6480464protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of FOS protein]CTDPMID:29133030
FosRat(20S)-ginsenoside Rh1 increases expressionISOFOS (Homo sapiens)6480464ginsenoside Rh1 results in increased expression of FOS mRNACTDPMID:16204943
FosRat(E)-roxithromycin increases expressionISOFOS (Homo sapiens)6480464Roxithromycin results in increased expression of FOS mRNA and Roxithromycin results in increased expression of FOS proteinCTDPMID:32454074
FosRat(R)-lipoic acid multiple interactionsEXP 6480464[Thioctic Acid co-treated with Propylthiouracil] results in decreased expression of FOS mRNACTDPMID:31068541

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Biological Process
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FosRatcellular response to calcium ion acts_upstream_of_or_withinISOFos (Mus musculus)1624291 PMID:19365557RGDPMID:19365557
FosRatcellular response to calcium ion acts_upstream_of_or_withinIEAUniProtKB:P01101 and ensembl:ENSMUSP000000216741600115GO_REF:0000107EnsemblGO_REF:0000107
FosRatcellular response to epidermal growth factor stimulus  IEP 151665808 RGD 
FosRatcellular response to hormone stimulus  IEP 2293788 RGD 
FosRatcellular response to hypoxia  IEP 151347626 RGD 
FosRatcellular response to parathyroid hormone stimulus  IEP 151665808 RGD 
FosRatcellular response to phorbol 13-acetate 12-myristate  IEP 151665808 RGD 
FosRatcellular response to prolactin  IEP 150524325 RGD 
FosRatcellular response to reactive oxygen species involved_inISOFOS (Homo sapiens)1624291 PMID:17217916RGDPMID:17217916
FosRatcellular response to reactive oxygen species involved_inIEAUniProtKB:P01100 and ensembl:ENSP000003062451600115GO_REF:0000107EnsemblGO_REF:0000107
FosRatcellular response to transforming growth factor beta stimulus  IEP 151665477 RGD 
FosRatcellular response to tumor necrosis factor  IEP 151665477 RGD 
FosRatcellular response to zinc ion starvation  IEP 151667428 RGD 
FosRatcerebral cortex development  IMP 405649740 RGD 
FosRatconditioned taste aversion  IEP 2293760 RGD 
FosRatfemale pregnancy  IEP 2293785 RGD 
FosRatmedium-term memory  IMP 405650620 RGD 
FosRatmononuclear cell differentiation  IEP 151665477 RGD 
FosRatmyoblast proliferation  IEP 151667421 RGD 
FosRatnervous system development acts_upstream_of_or_withinIEAUniProtKB:P01101 and ensembl:ENSMUSP000000216741600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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FosRatcytoplasm located_inISOFos (Mus musculus)1624291 PMID:26475860RGDPMID:26475860
FosRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
FosRatcytoplasm part_ofIEAUniProtKB:P01101 and ensembl:ENSMUSP000000216741600115GO_REF:0000107EnsemblGO_REF:0000107
FosRatcytosol located_inIEAUniProtKB-SubCell:SL-00911600115GO_REF:0000044UniProtGO_REF:0000044
FosRatendoplasmic reticulum  IDA 405649740 RGD 
FosRatendoplasmic reticulum located_inIEAUniProtKB-SubCell:SL-00951600115GO_REF:0000044UniProtGO_REF:0000044
FosRatendoplasmic reticulum part_ofIEAUniProtKB:P01101 and ensembl:ENSMUSP000000216741600115GO_REF:0000107EnsemblGO_REF:0000107
FosRatendoplasmic reticulum located_inISOFos (Mus musculus)1624291 PMID:26475860RGDPMID:26475860
FosRatendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
FosRatnuclear matrix  IDA 405650597 RGD 
FosRatnucleoplasm  IDA 405650597 RGD 
FosRatnucleoplasm located_inIEAUniProtKB:P01100 and ensembl:ENSP000003062451600115GO_REF:0000107EnsemblGO_REF:0000107
FosRatnucleoplasm located_inIEAUniProtKB:Q6FG41 and ensembl:ENSP000003062451600115GO_REF:0000107EnsemblGO_REF:0000107
FosRatnucleoplasm located_inISOFOS (Homo sapiens) and UniProtKB:P01100-11624291 RGDGO_REF:0000052
FosRatnucleoplasm located_inTAS 1600115Reactome:R-RNO-9620373ReactomeReactome:R-RNO-9620373
FosRatnucleus is_active_inIBAFB:FBgn0001297 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
FosRatnucleus located_inISOFos (Mus musculus)1624291 PMID:11747369 more ...RGDPMID:11747369 more ...
FosRatnucleus located_inIEAUniProtKB:P01100 and ensembl:ENSP000003062451600115GO_REF:0000107EnsemblGO_REF:0000107
FosRatnucleus located_inIEAUniProtKB:P01101 and ensembl:ENSMUSP000000216741600115GO_REF:0000107EnsemblGO_REF:0000107
FosRatnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
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Molecular Function
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FosRatchromatin binding enablesIEAUniProtKB:P01101 and ensembl:ENSMUSP000000216741600115GO_REF:0000107EnsemblGO_REF:0000107
FosRatchromatin binding enablesISOFos (Mus musculus)1624291 PMID:20442316RGDPMID:20442316
FosRatDNA binding enablesIEAUniProtKB-KW:KW-02381600115GO_REF:0000043UniProtGO_REF:0000043
FosRatDNA binding  IDA 1298921 RGD 
FosRatDNA binding enablesIEAARBA:ARBA000292241600115GO_REF:0000117UniProtGO_REF:0000117
FosRatDNA binding enablesIEAUniProtKB:P01101 and ensembl:ENSMUSP000000216741600115GO_REF:0000107EnsemblGO_REF:0000107
FosRatDNA binding enablesIEAInterPro:IPR0008371600115GO_REF:0000002InterProGO_REF:0000002
FosRatDNA binding enablesISOFos (Mus musculus)1624291 PMID:12486129RGDPMID:12486129
FosRatDNA-binding transcription activator activity, RNA polymerase II-specific enablesISOFOS (Homo sapiens)1624291 PMID:30670568RGDPMID:30670568
FosRatDNA-binding transcription activator activity, RNA polymerase II-specific enablesIEAUniProtKB:P01101 and ensembl:ENSMUSP000000216741600115GO_REF:0000107EnsemblGO_REF:0000107
FosRatDNA-binding transcription activator activity, RNA polymerase II-specific enablesIEAUniProtKB:P01100 and ensembl:ENSP000003062451600115GO_REF:0000107EnsemblGO_REF:0000107
FosRatDNA-binding transcription activator activity, RNA polymerase II-specific enablesISOFos (Mus musculus)1624291 PMID:11925568RGDPMID:11925568
FosRatDNA-binding transcription factor activity  IMP 1626699 RGD 
FosRatDNA-binding transcription factor activity  TAS 1298921 RGD 
FosRatDNA-binding transcription factor activity enablesIEAUniProtKB:P01100 and ensembl:ENSP000003062451600115GO_REF:0000107EnsemblGO_REF:0000107
FosRatDNA-binding transcription factor activity enablesIEAUniProtKB:P01101 and ensembl:ENSMUSP000000216741600115GO_REF:0000107EnsemblGO_REF:0000107
FosRatDNA-binding transcription factor activity enablesISOFos (Mus musculus)1624291MGI:2387304 PMID:11925568 and PMID:12220541RGDPMID:11925568 and PMID:12220541
FosRatDNA-binding transcription factor activity enablesIEAInterPro:IPR000837 more ...1600115GO_REF:0000002InterProGO_REF:0000002
FosRatDNA-binding transcription factor activity enablesISOFOS (Homo sapiens)1624291 PMID:10704222 and PMID:9732876RGDPMID:10704222 and PMID:9732876
FosRatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIBAFB:FBgn0001297 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
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Imported Annotations - KEGG (archival)

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FosRatB cell receptor signaling pathway  IEA 6907045 KEGGrno:04662
FosRatChagas disease pathway  IEA 6907045 KEGGrno:05142
FosRatcolorectal cancer pathway   IEA 6907045 KEGGrno:05210
FosRatLeishmaniasis pathway  IEA 6907045 KEGGrno:05140
FosRatmitogen activated protein kinase signaling pathway   IEA 6907045 KEGGrno:04010
FosRatrheumatoid arthritis pathway  IEA 6907045 KEGGrno:05323
FosRatT cell receptor signaling pathway  IEA 6907045 KEGGrno:04660
FosRatToll-like receptor signaling pathway   IEA 6907045 KEGGrno:04620

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Reference Title
Reference Citation
1. Expression and purification of the leucine zipper and DNA-binding domains of Fos and Jun: both Fos and Jun contact DNA directly. Abate C, etal., Proc Natl Acad Sci U S A 1990 Feb;87(3):1032-6.
2. Methamphetamine-associated memory is regulated by a writer and an eraser of permissive histone methylation. Aguilar-Valles A, etal., Biol Psychiatry. 2014 Jul 1;76(1):57-65. doi: 10.1016/j.biopsych.2013.09.014. Epub 2013 Oct 31.
3. The increase in c-fos expression in epileptic seizures is inhibited by magnetic field application, but not KCa1.1 channel expression. Akdağ MZ, etal., Electromagn Biol Med. 2023 Apr 3;42(2):81-97. doi: 10.1080/15368378.2023.2247027. Epub 2023 Aug 20.
4. Characteristics of c-fos gene expression in the brains of rats with different investigative and defensive behaviors. Babai P, etal., Neurosci Behav Physiol 2001 Nov-Dec;31(6):583-8.
5. Acute exercise-induced activation of Phox2b-expressing neurons of the retrotrapezoid nucleus in rats may involve the hypothalamus. Barna BF, etal., Neuroscience. 2014 Jan 31;258:355-63. doi: 10.1016/j.neuroscience.2013.11.031. Epub 2013 Nov 26.
6. Swim-stress but not opioid withdrawal increases expression of c-fos immunoreactivity in rat periaqueductal gray neurons which project to the rostral ventromedial medulla. Bellchambers CE, etal., Neuroscience. 1998 Mar;83(2):517-24. doi: 10.1016/s0306-4522(97)00399-0.
7. Prolactin receptor is associated with c-src kinase in rat liver. Berlanga JJ, etal., Mol Endocrinol. 1995 Nov;9(11):1461-7. doi: 10.1210/mend.9.11.8584023.
8. Expression of c-Fos, ICER, Krox-24 and JunB in the whisker-to-barrel pathway of rats: time course of induction upon whisker stimulation by tactile exploration of an enriched environment. Bisler S, etal., J Chem Neuroanat 2002 Mar;23(3):187-98.
9. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, etal., Genome Res 1996 Sep;6(9):791-806.
10. Temporal and regional expression of Fos-related proteins in response to ischemic injury. Butler TL and Pennypacker KR, Brain Res Bull. 2004 Mar 1;63(1):65-73.
11. Modulation of cellular AP-1 DNA binding activity by heat shock proteins. Carter DA FEBS Lett. 1997 Oct 13;416(1):81-5.
12. Acupuncture attenuates repeated nicotine-induced behavioral sensitization and c-Fos expression in the nucleus accumbens and striatum of the rat. Chae Y, etal., Neurosci Lett. 2004 Mar 25;358(2):87-90. doi: 10.1016/j.neulet.2003.12.121.
13. Augmented upregulation by c-fos of angiotensin subtype 1 receptor in nucleus tractus solitarii of spontaneously hypertensive rats. Chan JY, etal., Hypertension 2002 Sep;40(3):335-41.
14. Conditioned response evoked by nicotine conditioned stimulus preferentially induces c-Fos expression in medial regions of caudate-putamen. Charntikov S, etal., Neuropsychopharmacology. 2012 Mar;37(4):876-84. doi: 10.1038/npp.2011.263. Epub 2011 Nov 2.
15. Distinctive features of Egr transcription factor regulation and DNA binding activity in CA1 of the hippocampus in synaptic plasticity and consolidation and reconsolidation of fear memory. Cheval H, etal., Hippocampus. 2011 Mar 18. doi: 10.1002/hipo.20926.
16. Proto-oncogene expression in proliferating and differentiating cardiac and skeletal muscle. Claycomb WC and Lanson NA, Biochem J. 1987 Nov 1;247(3):701-6. doi: 10.1042/bj2470701.
17. Induction of differential patterns of local cerebral glucose metabolism and immediate-early genes by acute clozapine and haloperidol. Cochran SM, etal., Neuropharmacology. 2002 Sep;43(3):394-407.
18. Calcium channel antagonists delay regression of androgen-dependent tissues and suppress gene activity associated with cell death. Connor J, etal., Prostate 1988;13(2):119-30.
19. Isolation and characterization of the c-fos(rat) cDNA and analysis of post-translational modification in vitro. Curran T, etal., Oncogene 1987;2(1):79-84.
20. Cloning of the cDNA encoding human C/EBP gamma, a protein binding to the PRE-I enhancer element of the human interleukin-4 promoter. Davydov IV, etal., Gene. 1995 Aug 19;161(2):271-5.
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PMID:1298921   PMID:7990028   PMID:8206384   PMID:9098922   PMID:9294610   PMID:9732876   PMID:9847304   PMID:9879931   PMID:10508860   PMID:10523647   PMID:10704222   PMID:11053448  
PMID:11747369   PMID:11766904   PMID:11860940   PMID:11861123   PMID:11925568   PMID:11939505   PMID:12064606   PMID:12121970   PMID:12184859   PMID:12220541   PMID:12370534   PMID:12384476  
PMID:12429561   PMID:12443984   PMID:12486129   PMID:12528378   PMID:12531532   PMID:12535784   PMID:12606042   PMID:12629509   PMID:12714357   PMID:12787062   PMID:12802426   PMID:12834907  
PMID:12943993   PMID:14625026   PMID:14674859   PMID:14757116   PMID:14767061   PMID:14979778   PMID:15014501   PMID:15024755   PMID:15033433   PMID:15044536   PMID:15051527   PMID:15115808  
PMID:15136564   PMID:15189768   PMID:15249992   PMID:15254773   PMID:15306261   PMID:15334681   PMID:15380004   PMID:15453261   PMID:15458969   PMID:15522236   PMID:15609068   PMID:15701816  
PMID:15702242   PMID:15748507   PMID:15842237   PMID:15922053   PMID:15926928   PMID:16039502   PMID:16055265   PMID:16095819   PMID:16097052   PMID:16110275   PMID:16130823   PMID:16169531  
PMID:16259361   PMID:16344157   PMID:16531639   PMID:16547969   PMID:16555238   PMID:16604387   PMID:16633904   PMID:16850590   PMID:16926533   PMID:16927803   PMID:16962079   PMID:17005860  
PMID:17006656   PMID:17020011   PMID:17101878   PMID:17111371   PMID:17120244   PMID:17147208   PMID:17152352   PMID:17194726   PMID:17216194   PMID:17217916   PMID:17218446   PMID:17244536  
PMID:17393298   PMID:17448703   PMID:17482654   PMID:17504975   PMID:17506118   PMID:17513031   PMID:17514764   PMID:17524563   PMID:17551755   PMID:17553714   PMID:17562390   PMID:17592200  
PMID:17622784   PMID:17654838   PMID:17661378   PMID:17669374   PMID:17681951   PMID:17706947   PMID:17828499   PMID:17850462   PMID:17853060   PMID:17873368   PMID:17884026   PMID:17936859  
1 to 10 of 31 rows



Fos
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86110,852,188 - 110,855,054 (+)NCBIGRCr8
mRatBN7.26105,121,170 - 105,124,036 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6105,121,170 - 105,124,036 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6105,290,640 - 105,293,508 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06105,589,531 - 105,592,399 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06104,959,176 - 104,962,044 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06109,300,433 - 109,303,299 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6109,300,433 - 109,303,299 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06116,249,742 - 116,252,608 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46109,559,135 - 109,562,001 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16109,562,609 - 109,566,002 (+)NCBI
Celera6102,942,464 - 102,945,330 (+)NCBICelera
Cytogenetic Map6q31NCBI
FOS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381475,278,828 - 75,282,230 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1475,278,826 - 75,283,190 (+)EnsemblGRCh38hg38GRCh38
GRCh371475,745,531 - 75,748,933 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361474,815,284 - 74,818,666 (+)NCBINCBI36Build 36hg18NCBI36
Build 341474,815,283 - 74,818,666NCBI
Celera1455,783,567 - 55,787,023 (+)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1455,913,924 - 55,917,380 (+)NCBIHuRef
CHM1_11475,683,266 - 75,686,721 (+)NCBICHM1_1
T2T-CHM13v2.01469,488,228 - 69,491,630 (+)NCBIT2T-CHM13v2.0
Fos
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391285,520,664 - 85,524,048 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1285,520,664 - 85,524,047 (+)EnsemblGRCm39 Ensembl
GRCm381285,473,890 - 85,477,274 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1285,473,890 - 85,477,273 (+)EnsemblGRCm38mm10GRCm38
MGSCv371286,814,851 - 86,818,219 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361286,363,004 - 86,366,372 (+)NCBIMGSCv36mm8
Celera1286,933,225 - 86,936,593 (+)NCBICelera
Cytogenetic Map12D2NCBI
cM Map1239.7NCBI
Fos
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955523305,728 - 310,728 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955523307,181 - 310,728 (-)NCBIChiLan1.0ChiLan1.0
FOS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21576,362,508 - 76,366,629 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11475,579,607 - 75,583,133 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01455,832,570 - 55,835,984 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11474,676,316 - 74,679,766 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1474,676,316 - 74,679,766 (+)Ensemblpanpan1.1panPan2
FOS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1848,330,856 - 48,334,273 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl848,331,026 - 48,333,467 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha848,014,730 - 48,018,137 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0848,558,356 - 48,561,763 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl848,558,343 - 48,561,758 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1848,229,017 - 48,232,423 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0848,250,295 - 48,253,702 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0848,649,028 - 48,652,435 (+)NCBIUU_Cfam_GSD_1.0
Fos
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864027,680,843 - 27,684,228 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364884,384,705 - 4,388,122 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364884,384,710 - 4,388,118 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl798,449,349 - 98,455,554 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1798,449,508 - 98,451,971 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27104,293,828 - 104,296,291 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FOS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12452,497,465 - 52,501,161 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2452,497,521 - 52,501,514 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605340,725,132 - 40,728,594 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fos
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473426,423,079 - 26,427,732 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473426,424,053 - 26,427,431 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

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Variants in Fos
10 total Variants


Assembly: RGSC_v3.4
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
6 109560276 109560277 T G snv FHH/EurMcwi (MCW), SR/JrHsd (MCW), SS/JrHsdMcwi (MCW), FHL/EurMcwi (MCW) View more Information


Assembly: Rnor_6.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
6 109301574 109301575 T G snv FHL/EurMcwi (MCW) View more Information

Predicted Target Of
Summary Value
Count of predictions:143
Count of miRNA genes:105
Interacting mature miRNAs:116
Transcripts:ENSRNOT00000010712
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 30 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat

1 to 10 of 30 rows
Fos  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26105,122,222 - 105,122,470 (+)MAPPERmRatBN7.2
Rnor_6.06109,301,486 - 109,301,733NCBIRnor6.0
Rnor_5.06116,251,308 - 116,251,555UniSTSRnor5.0
RGSC_v3.46109,560,188 - 109,560,435UniSTSRGSC3.4
Celera6102,943,517 - 102,943,764UniSTS
Cytogenetic Map6q31UniSTS
WI-19801  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26105,123,847 - 105,124,149 (+)MAPPERmRatBN7.2
Rnor_6.06109,303,111 - 109,303,412NCBIRnor6.0
Rnor_5.06116,249,629 - 116,249,930UniSTSRnor5.0
RGSC_v3.46109,561,813 - 109,562,114UniSTSRGSC3.4
Celera6102,945,142 - 102,945,443UniSTS
Cytogenetic Map6q31UniSTS
PMC151804P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26105,122,906 - 105,123,431 (+)MAPPERmRatBN7.2
Rnor_6.06109,302,170 - 109,302,694NCBIRnor6.0
Rnor_5.06116,250,347 - 116,250,871UniSTSRnor5.0
RGSC_v3.46109,560,872 - 109,561,396UniSTSRGSC3.4
Celera6102,944,201 - 102,944,725UniSTS
Cytogenetic Map6q31UniSTS
PMC108124P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26105,122,435 - 105,123,350 (+)MAPPERmRatBN7.2
Rnor_6.06109,301,699 - 109,302,613NCBIRnor6.0
Rnor_5.06116,250,428 - 116,251,342UniSTSRnor5.0
RGSC_v3.46109,560,401 - 109,561,315UniSTSRGSC3.4
Celera6102,943,730 - 102,944,644UniSTS
Cytogenetic Map6q31UniSTS
PMC321436P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr86110,853,933 - 110,854,154 (+)Marker Load Pipeline
mRatBN7.26105,122,914 - 105,123,136 (+)MAPPERmRatBN7.2
Rnor_6.06109,302,178 - 109,302,399NCBIRnor6.0
Rnor_5.06116,250,642 - 116,250,863UniSTSRnor5.0
RGSC_v3.46109,560,880 - 109,561,101UniSTSRGSC3.4
Celera6102,944,209 - 102,944,430UniSTS
Cytogenetic Map6q31UniSTS
PMC99986P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26105,120,896 - 105,121,180 (+)MAPPERmRatBN7.2
Rnor_6.06109,300,160 - 109,300,443NCBIRnor6.0
Rnor_5.06116,252,598 - 116,252,881UniSTSRnor5.0
RGSC_v3.46109,558,862 - 109,559,145UniSTSRGSC3.4
Celera6102,942,191 - 102,942,474UniSTS
Cytogenetic Map6q31UniSTS
BP240034A10G4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26105,124,058 - 105,124,364 (+)MAPPERmRatBN7.2
Rnor_6.06109,303,322 - 109,303,627NCBIRnor6.0
Rnor_5.06116,249,414 - 116,249,719UniSTSRnor5.0
RGSC_v3.46109,562,024 - 109,562,329UniSTSRGSC3.4
Celera6102,945,353 - 102,945,658UniSTS
Cytogenetic Map6q31UniSTS
Fos  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26105,124,316 - 105,124,496 (+)MAPPERmRatBN7.2
Rnor_6.06109,303,580 - 109,303,759NCBIRnor6.0
Rnor_5.06116,249,282 - 116,249,461UniSTSRnor5.0
RGSC_v3.46109,562,282 - 109,562,461UniSTSRGSC3.4
Celera6102,945,611 - 102,945,790UniSTS
Cytogenetic Map6q31UniSTS
Fos  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26105,124,370 - 105,124,546 (+)MAPPERmRatBN7.2
Rnor_6.06109,303,634 - 109,303,809NCBIRnor6.0
Rnor_5.06116,249,232 - 116,249,407UniSTSRnor5.0
RGSC_v3.46109,562,336 - 109,562,511UniSTSRGSC3.4
Celera6102,945,665 - 102,945,840UniSTS
Cytogenetic Map6q31UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 16 of 16 rows
RefSeq Transcripts NM_022197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF126534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF277645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY780201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY780202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY780203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY786174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY828998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY828999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ089699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M34001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U02631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 16 of 16 rows

Ensembl Acc Id: ENSRNOT00000010712   ⟹   ENSRNOP00000010712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6105,121,170 - 105,124,036 (+)Ensembl
Rnor_6.0 Ensembl6109,300,433 - 109,303,299 (+)Ensembl
RefSeq Acc Id: NM_022197   ⟹   NP_071533
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86110,852,188 - 110,855,054 (+)NCBI
mRatBN7.26105,121,170 - 105,124,036 (+)NCBI
Rnor_6.06109,300,433 - 109,303,299 (+)NCBI
Rnor_5.06116,249,742 - 116,252,608 (-)NCBI
RGSC_v3.46109,559,135 - 109,562,001 (+)RGD
Celera6102,942,464 - 102,945,330 (+)RGD
Sequence:
RefSeq Acc Id: NP_071533   ⟸   NM_022197
- UniProtKB: Q4FDN1 (UniProtKB/Swiss-Prot),   P12841 (UniProtKB/Swiss-Prot),   A6JE29 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010712   ⟸   ENSRNOT00000010712
bZIP

Name Modeler Protein Id AA Range Protein Structure
AF-P12841-F1-model_v2 AlphaFold P12841 1-380 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694742
Promoter ID:EPDNEW_R5267
Type:single initiation site
Name:Fos_1
Description:Fos proto-oncogene, AP-1 transcription factor subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06109,300,435 - 109,300,495EPDNEW


1 to 31 of 31 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-36778 BioCyc
Ensembl Genes ENSRNOG00000008015 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010712 ENTREZGENE
  ENSRNOT00000010712.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
InterPro AP-1 UniProtKB/Swiss-Prot
  bZIP UniProtKB/Swiss-Prot
  bZIP_sf UniProtKB/Swiss-Prot
KEGG Report rno:314322 UniProtKB/Swiss-Prot
NCBI Gene Fos ENTREZGENE
PANTHER PTHR23351 UniProtKB/Swiss-Prot
  PTHR23351:SF4 UniProtKB/Swiss-Prot
Pfam bZIP_1 UniProtKB/Swiss-Prot
PhenoGen Fos PhenoGen
PRINTS LEUZIPPRFOS UniProtKB/Swiss-Prot
PROSITE BZIP UniProtKB/Swiss-Prot
  BZIP_BASIC UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008015 RatGTEx
SMART BRLZ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57959 UniProtKB/Swiss-Prot
UniProt A6JE29 ENTREZGENE, UniProtKB/TrEMBL
  A6JE31_RAT UniProtKB/TrEMBL
  FOS_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4FDN1 ENTREZGENE
  Q5G6W2_RAT UniProtKB/TrEMBL
  Q5G6W3_RAT UniProtKB/TrEMBL
  Q5U7E3_RAT UniProtKB/TrEMBL
  Q5U873_RAT UniProtKB/TrEMBL
  Q5U874_RAT UniProtKB/TrEMBL
  Q5U875_RAT UniProtKB/TrEMBL
UniProt Secondary Q4FDN1 UniProtKB/Swiss-Prot
1 to 31 of 31 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-07 Fos  Fos proto-oncogene, AP-1 transcription factor subunit  Fos  FBJ osteosarcoma oncogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Fos  FBJ osteosarcoma oncogene  Fos  FBJ murine osteosarcoma viral oncogene homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-02-28 Fos  FBJ murine osteosarcoma viral oncogene homolog  c-fos  c-fos oncogene  Data merged from RGD:735054 737654 APPROVED
2005-01-20 Fos  FBJ murine osteosarcoma viral oncogene homolog    v-fos FBJ murine osteosarcoma viral oncogene homolog  Name updated 1299863 APPROVED
2002-06-10 Fos  v-fos FBJ murine osteosarcoma viral oncogene homolog      Name updated 70585 PROVISIONAL

Note Type Note Reference
gene_function may play a role in androgen regulated apoptosis 70259
gene_physical_interaction forms heterodimeric complexes with proteins of the Jun family which then bind to the AP-1 gene promoter site to regulate gene expression 1302797
gene_process increases the intracellular calcium ion levels which helps in the degradation of phosphatidyl inositol and activation of protein kinase C 70259
gene_process increases transcription associated with cell death in prostate regression 70259
gene_regulation expression is induced in response to airpuff startle in hypothalamus, thalamus, midbrain, pons and medulla 1358971