Fos (Fos proto-oncogene, AP-1 transcription factor subunit) - Rat Genome Database

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Gene: Fos (Fos proto-oncogene, AP-1 transcription factor subunit) Rattus norvegicus
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Symbol: Fos
Name: Fos proto-oncogene, AP-1 transcription factor subunit
RGD ID: 2626
Description: Enables DNA-binding transcription factor activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; response to peptide hormone; and response to steroid hormone. Located in nucleus. Used to study morphine dependence. Biomarker of congestive heart failure; glomerulonephritis; and hypertension. Orthologous to human FOS (Fos proto-oncogene, AP-1 transcription factor subunit); PARTICIPATES IN endothelin signaling pathway; fibroblast growth factor signaling pathway; forkhead class A signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-taxifolin; (+)-Tetrandrine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: c-fos; c-fos oncogene; cellular oncogene fos; FBJ murine osteosarcoma viral (v-fos) oncogene homolog; FBJ murine osteosarcoma viral oncogene homolog; FBJ osteosarcoma oncogene; proto-oncogene c-FOS; proto-oncogene cFOS; v-fos FBJ murine osteosarcoma viral oncogene homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86110,852,188 - 110,855,054 (+)NCBIGRCr8
mRatBN7.26105,121,170 - 105,124,036 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6105,121,170 - 105,124,036 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6105,290,640 - 105,293,508 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06105,589,531 - 105,592,399 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06104,959,176 - 104,962,044 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06109,300,433 - 109,303,299 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6109,300,433 - 109,303,299 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06116,249,742 - 116,252,608 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46109,559,135 - 109,562,001 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16109,562,609 - 109,566,002 (+)NCBI
Celera6102,942,464 - 102,945,330 (+)NCBICelera
Cytogenetic Map6q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Aberrant Crypt Foci  (IDA,IEP)
alcohol dependence  (IDA,IEP)
alcohol use disorder  (IDA,IEP,ISO)
alcohol withdrawal syndrome  (IEP)
Alcohol-Related Disorders  (IEP)
Alcoholic Intoxication  (IEP)
amphetamine abuse  (IEP,ISO)
amyotrophic lateral sclerosis type 1  (ISO)
Animal Disease Models  (ISO)
anxiety disorder  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
Binge Drinking  (IEP)
Brain Injuries  (ISO)
Breast Neoplasms  (ISO)
cervical squamous cell carcinoma  (ISO)
cocaine abuse  (ISO)
cocaine dependence  (IEP)
Cocaine-Related Disorders  (IEP,ISO)
Colonic Neoplasms  (ISO)
colorectal adenocarcinoma  (ISO)
colorectal adenoma  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (IEP)
endometriosis  (ISO)
epilepsy  (ISO)
Experimental Liver Cirrhosis  (ISO)
extrahepatic cholestasis  (ISO)
Fibrous Dysplasia of Bone  (ISO)
genetic disease  (ISO)
glomerulonephritis  (IEP)
Heat Stroke  (ISO)
Hematuria  (IDA,IEP)
hemolytic-uremic syndrome  (ISO)
Hemorrhage  (ISO)
hepatocellular carcinoma  (ISO)
Hyperalgesia  (IEP,ISO)
Hyperkinesis  (ISO)
hypertension  (IEP,ISO)
Inhalant Abuse  (IEP)
intellectual disability  (ISO)
juvenile rheumatoid arthritis  (ISO)
Kidney Reperfusion Injury  (ISO)
Lung Neoplasms  (ISO)
middle cerebral artery infarction  (ISO)
morphine dependence  (IDA,IEP,IMP)
morphine withdrawal syndrome  (IEP)
myocardial infarction  (IEP)
Neoplastic Cell Transformation  (ISO)
nervous system disease  (ISO)
nicotine dependence  (IEP,ISO)
obesity  (ISO)
ovarian carcinoma  (ISO)
Pick's disease  (ISO)
post-traumatic stress disorder  (ISO)
rectal benign neoplasm  (ISO)
Reperfusion Injury  (IEP,ISO)
status epilepticus  (ISO)
Tendon Injuries  (IDA)
Tongue Neoplasms  (IEP)
tongue squamous cell carcinoma  (ISO)
toxic encephalopathy  (ISO)
trigeminal neuralgia  (ISO)
Wernicke encephalopathy  (IEP)
withdrawal disorder  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-pilocarpine  (EXP)
(+)-Pimaric acid  (ISO)
(+)-taxifolin  (EXP)
(+)-Tetrandrine  (EXP)
(-)-alpha-phellandrene  (ISO)
(-)-anisomycin  (ISO)
(-)-citrinin  (ISO)
(-)-demecolcine  (ISO)
(-)-ephedrine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-selegiline  (ISO)
(20R)-protopanaxadiol  (ISO)
(20S)-ginsenoside Rh1  (ISO)
(E)-roxithromycin  (ISO)
(R)-lipoic acid  (EXP)
(R)-noradrenaline  (EXP,ISO)
(S)-amphetamine  (EXP,ISO)
(S)-colchicine  (EXP)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
(Z)-ligustilide  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2,4,5-tetrachlorobenzene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,2-naphthoquinone  (ISO)
1,4-dichlorobenzene  (EXP)
1-(3-chlorophenyl)piperazine  (EXP,ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1D-myo-inositol 1,4,5-trisphosphate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4,6-trinitrotoluene  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP,ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-amino-3-hydroxypyridine  (ISO)
2-aminopurine  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (EXP)
2-nitrotoluene  (EXP)
2-tert-butylhydroquinone  (EXP,ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
22-Hydroxycholesterol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP,ISO)
3-iodobenzyl-5'-N-methylcarboxamidoadenosine  (EXP)
3-Methoxynobiletin  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4,5,6,7-TETRABROMOBENZOTRIAZOLE  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol  (EXP,ISO)
4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide  (ISO)
4-DAMP(1+)  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitrophenol  (ISO)
4-nonylphenol  (ISO)
4-octylphenol  (ISO)
4-tert-Octylphenol  (EXP)
5,6,7-trimethoxyflavone  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP,ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
6-Cyano-7-nitroquinoxaline-2,3-dione  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
8-(3-chlorostyryl)caffeine  (EXP)
8-OH-DPAT  (EXP,ISO)
9-Methoxycamptothecin  (ISO)
acebutolol  (ISO)
acephate  (EXP)
acetaldehyde  (EXP,ISO)
acetylsalicylic acid  (EXP,ISO)
acrivastine  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (ISO)
actinomycin D  (EXP,ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
AH23848  (ISO)
alcohol  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
alfuzosin  (EXP)
Alisol B  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allopurinol  (ISO)
alpha-hexachlorocyclohexane  (EXP)
alpha-naphthoflavone  (ISO)
alpha-phellandrene  (ISO)
alpha-pinene  (ISO)
aluminium atom  (ISO)
aluminium oxide  (ISO)
aluminium(0)  (ISO)
AM-251  (ISO)
amiloride  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
ammonium hydroxide  (EXP)
amphetamine  (EXP,ISO)
anandamide  (EXP)
andrographolide  (ISO)
aniline  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimonite  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
apomorphine  (EXP)
arachidonic acid  (ISO)
arecoline  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP,ISO)
arsane  (ISO)
arsenic acid  (EXP)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
asbestos  (ISO)
astressin  (EXP)
ATP  (EXP,ISO)
atrazine  (EXP,ISO)
atropine  (EXP,ISO)
avobenzone  (ISO)
Azaspiracid  (ISO)
azathioprine  (ISO)
azithromycin  (ISO)
baclofen  (EXP,ISO)
BAPTA  (EXP)
bathocuproine disulfonic acid  (ISO)
Bay-K-8644  (EXP,ISO)
bazedoxifene  (ISO)
beclomethasone  (ISO)
benazepril  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
benzofurans  (ISO)
benzophenone  (ISO)
Benzoyl peroxide  (ISO)
Bergenin  (EXP)
beryllium difluoride  (ISO)
beryllium sulfate  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (EXP,ISO)
bezafibrate  (ISO)
bicalutamide  (ISO)
bilobalide  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
bromochloroacetic acid  (EXP)
bucladesine  (ISO)
bufalin  (ISO)
bupropion  (ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (EXP,ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
butyric acid  (EXP)
C.I. Natural Red 20  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
Calcimycin  (EXP,ISO)
calcitriol  (ISO)
Calphostin C  (EXP)
calyculin a  (ISO)
camostat  (ISO)
candesartan  (EXP)
cannabidiol  (EXP,ISO)
cannabidiolic acid  (ISO)
Cannabinol  (ISO)
capsaicin  (EXP,ISO)
capsazepine  (EXP)
captan  (ISO)
carbachol  (EXP,ISO)
carbamazepine  (EXP,ISO)
carbaryl  (ISO)
carbon nanotube  (ISO)
carnosine  (EXP)
carrageenan  (EXP)
cefaloridine  (EXP)
celecoxib  (EXP,ISO)
cerium trichloride  (ISO)
CGS-21680  (EXP)
chenodeoxycholic acid  (ISO)
chloral hydrate  (EXP)
Chloralose  (EXP)
chlormequat chloride  (EXP)
chloroform  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpromazine  (ISO)
chlorpropamide  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (EXP,ISO)
chrysene  (ISO)
chrysin  (ISO)
ciglitazone  (EXP,ISO)
ciguatoxin CTX1B  (ISO)
Cinobufagin  (ISO)
ciprofibrate  (ISO)
cisapride  (ISO)
cisplatin  (EXP,ISO)
clarithromycin  (ISO)
clofibrate  (ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
clotrimazole  (ISO)
clozapine  (EXP,ISO)
cobalt atom  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cobalt(2+) sulfate  (ISO)
cocaine  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corilagin  (ISO)
corticosterone  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (EXP,ISO)
CU-O LINKAGE  (ISO)
curcumin  (EXP,ISO)
cyanamide  (EXP)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (EXP,ISO)
D-cycloserine  (EXP)
D-glucose  (EXP,ISO)
D-mannitol  (EXP)
daidzein  (ISO)
daidzein 7-O-beta-D-glucoside  (ISO)
DDE  (ISO)
DDT  (EXP,ISO)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
dehydroepiandrosterone  (ISO)
dehydroepiandrosterone sulfate  (ISO)
delta-hexachlorocyclohexane  (EXP)
deoxynivalenol  (ISO)
desipramine  (EXP)
Destruxin B  (ISO)
devazepide  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dextromethorphan  (EXP,ISO)
Diallyl sulfide  (EXP)
diallyl trisulfide  (ISO)
diamminedichloroplatinum  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diarylheptanoid  (ISO)
diazepam  (EXP,ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
dieckol  (ISO)
dieldrin  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP,ISO)
diflunisal  (ISO)
diiodine  (EXP)
diisopropyl fluorophosphate  (EXP)
Dimaprit  (ISO)
dimemorfan  (EXP,ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (ISO)
dimethyldithiocarbamate  (EXP)
dinophysistoxin 1  (ISO)
dioxygen  (EXP,ISO)
diphenylcyclopropenone  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dipyridamole  (ISO)
diquat  (ISO)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
dizocilpine maleate  (EXP,ISO)
dobutamine  (EXP)
donepezil hydrochloride  (ISO)
dopamine  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
doxycycline  (ISO)
ebselen  (ISO)
elemental selenium  (EXP)
ellagic acid  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ergotamine  (EXP)
ergothioneine  (EXP)
Erionite  (EXP)
erythromycin A  (ISO)
estra-1,3,5(10)-triene-3,16beta-diol  (EXP)
estriol  (EXP)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
eticlopride(1+)  (EXP)
etoposide  (EXP,ISO)
famotidine  (ISO)
farnesyl diphosphate  (ISO)
fenfluramine  (EXP)
fentanyl  (EXP)
fenthion  (ISO)
ferric oxide  (ISO)
ferroheme b  (ISO)
ferrosoferric oxide  (ISO)
fingolimod hydrochloride  (ISO)
fisetin  (ISO)
Flavokawain A  (ISO)
flecainide  (ISO)
flumequine  (ISO)
fluoranthene  (ISO)
fluoxetine  (EXP,ISO)
flurbiprofen  (EXP,ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (EXP,ISO)
formononetin  (ISO)
fotemustine  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
furan  (EXP)
furosemide  (EXP,ISO)
gamma-hexachlorocyclohexane  (EXP,ISO)
gamma-tocopherol  (ISO)
gefitinib  (ISO)
Geniposide pentaacetate  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP)
geraniol  (ISO)
ginsenoside Rb1  (ISO)
ginsenoside Re  (ISO)
ginsenoside Rg1  (ISO)
glucaric acid  (ISO)
glucose  (EXP,ISO)
glufosinate  (ISO)
glutathione  (ISO)
glycidol  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
haloperidol  (EXP,ISO)
halothane  (EXP)
helioxanthin  (ISO)
heme b  (ISO)
hemin  (ISO)
heparin  (EXP,ISO)
herbimycin  (EXP)
heroin  (EXP)
hexachlorobenzene  (EXP)
Hexamethonium  (EXP)
histamine  (ISO)
hydralazine  (EXP)
hydrogen chloride  (EXP)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
hydroxyurea  (ISO)
hypochlorous acid  (ISO)
icariin  (ISO)
idazoxan  (ISO)
ifosfamide  (EXP)
imipramine  (EXP)
indapamide  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP)
iodoform  (ISO)
ionomycin  (EXP,ISO)
iprodione  (ISO)
irinotecan  (ISO)
iron atom  (EXP)
iron dextran  (EXP)
iron dichloride  (ISO)
iron(0)  (EXP)
iron(III) nitrilotriacetate  (ISO)
isobutanol  (ISO)
isoflurane  (EXP)
isoprenaline  (EXP,ISO)
Isorhapontigenin  (EXP)
isotretinoin  (ISO)
istradefylline  (EXP)
josamycin  (ISO)
kaempferol  (ISO)
kainic acid  (EXP,ISO)
kenpaullone  (EXP)
ketamine  (EXP)
ketorolac  (EXP)
KT 5823  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
L-selenocysteine  (ISO)
lanthanum atom  (EXP)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
lead(0)  (EXP,ISO)
leflunomide  (ISO)
levamisole  (ISO)
Licochalcone B  (ISO)
lidocaine  (EXP,ISO)
linalool  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP,ISO)
lithium chloride  (EXP)
lithium hydride  (EXP,ISO)
losartan  (EXP,ISO)
lovastatin  (EXP,ISO)
luteolin  (EXP,ISO)
luteolin 7-O-beta-D-glucoside  (ISO)
LY294002  (ISO)
lycopene  (ISO)
lysergic acid diethylamide  (EXP)
m-Chlorophenylbiguanide  (EXP)
mancozeb  (ISO)
maneb  (EXP,ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
masoprocol  (ISO)
mebendazole  (ISO)
mechlorethamine  (ISO)
MeIQx  (ISO)
melatonin  (EXP)
menadione  (ISO)
mercury atom  (EXP)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP)
metformin  (EXP,ISO)
methamidophos  (EXP)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methotrexate  (EXP,ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylglyoxal  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
methylphenidate  (EXP,ISO)
metoprolol  (EXP)
metyrapone  (EXP)
miconazole  (EXP)
microcystin-LR  (ISO)
Midecamycin  (ISO)
mifepristone  (EXP)
mitomycin C  (ISO)
ML-7  (EXP)
modafinil  (ISO)
Mofezolac (TN)  (EXP)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monocrotophos  (EXP)
monosodium L-glutamate  (EXP)
morin  (EXP)
morphine  (EXP,ISO)
Muconic dialdehyde  (ISO)
muscimol  (EXP)
mycophenolic acid  (ISO)
myricetin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
N-phenylthiourea  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nabumetone  (ISO)
nafadotride  (EXP)
naloxone  (EXP,ISO)
naphthalene  (ISO)
naringin  (ISO)
nefazodone  (ISO)
neurotensin  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP)
nickel subsulfide  (EXP,ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotinamide  (EXP)
nicotine  (EXP,ISO)
nifedipine  (EXP,ISO)
nilotinib  (ISO)
nimodipine  (EXP,ISO)
nimustine  (ISO)
nitrofen  (EXP)
nitrogen dioxide  (EXP)
nitroglycerin  (EXP,ISO)
nitroprusside  (EXP,ISO)
nobiletin  (EXP)
Nodularin  (ISO)
nomifensine  (EXP)
Nonylphenol  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (EXP,ISO)
olanzapine  (EXP)
omega-conotoxin GVIA  (EXP)
organoselenium compound  (ISO)
oroxylin A  (ISO)
oxaliplatin  (EXP,ISO)
oxidopamine  (EXP)
Oxotremorine  (EXP)
oxotremorine M  (ISO)
oxycodone  (EXP)
oxytocin  (EXP)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
p-menthan-3-ol  (EXP)
p-tert-Amylphenol  (EXP)
palytoxin  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
paraquat  (EXP,ISO)
parathion-methyl  (EXP)
patulin  (EXP,ISO)
PCB138  (EXP)
PD 0325901  (EXP,ISO)
pentachlorobenzene  (EXP)
pentachlorophenol  (ISO)
pentetrazol  (EXP,ISO)
pentobarbital  (EXP,ISO)
Pentoxifylline  (ISO)
perchlorate  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perindopril  (EXP)
permethrin  (EXP,ISO)
peroxynitrous acid  (ISO)
phencyclidine  (EXP)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP,ISO)
phenytoin  (EXP)
PhIP  (EXP,ISO)
phorbol 12,13-dibutanoate  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phorone  (EXP)
phosgene  (ISO)
phylloquinone  (ISO)
physostigmine  (EXP)
picrotoxin  (EXP)
picrotoxinin  (EXP)
pimozide  (EXP)
pioglitazone  (EXP)
piperine  (ISO)
piperonyl butoxide  (ISO)
pipoxolan  (ISO)
pirenzepine  (EXP)
pirinixic acid  (ISO)
platycodin D  (ISO)
poly(ethylene)  (ISO)
potassium atom  (EXP,ISO)
potassium chloride  (EXP)
potassium chromate  (ISO)
potassium cyanide  (EXP)
prazosin  (EXP,ISO)
pregabalin  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
promegestone  (ISO)
propan-2-ol  (ISO)
propanal  (ISO)
propofol  (EXP)
propranolol  (EXP)
prostaglandin E2  (ISO)
protein kinase inhibitor  (EXP)
protoporphyrin  (ISO)
pterostilbene  (ISO)
puerarin  (ISO)
putrescine  (EXP)
pyrethrins  (ISO)
pyridine  (EXP)
pyrimethamine  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
quinapril hydrochloride  (EXP)
quinolin-8-ol  (ISO)
quinolinic acid  (EXP)
quinomethionate  (ISO)
quinpirole  (EXP)
rac-lactic acid  (ISO)
ranitidine  (EXP)
reactive oxygen species  (ISO)
reboxetine  (EXP)
reserpine  (EXP)
resiniferatoxin  (EXP,ISO)
resveratrol  (EXP,ISO)
rimonabant  (EXP,ISO)
risperidone  (EXP,ISO)
ritonavir  (ISO)
Ro 31-8220  (ISO)
rosmarinic acid  (EXP)
rotenone  (EXP,ISO)
rottlerin  (ISO)
rutin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
SB 203580  (EXP,ISO)
SB 206553  (EXP)
SB 431542  (ISO)
SCH 23390  (EXP)
SCH772984  (EXP)
sclareol  (ISO)
scopolamine  (EXP,ISO)
selenium atom  (EXP)
selenomethionine  (ISO)
selumetinib  (ISO)
serotonin  (EXP)
serpentine asbestos  (EXP)
sertraline  (EXP,ISO)
Shikonin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
simvastatin  (EXP,ISO)
SKF 38393  (EXP,ISO)
SL-327  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium azide  (EXP)
sodium chloride  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (EXP,ISO)
sodium fluoride  (ISO)
sodium perchlorate  (EXP)
Soman  (EXP)
spiramycin II  (ISO)
staurosporine  (EXP)
sterigmatocystin  (EXP)
stilben-4-ol  (ISO)
stilbene-4,4'-diol  (ISO)
streptozocin  (ISO)
styrene  (ISO)
sulfur dioxide  (EXP)
sulindac  (ISO)
sumatriptan  (ISO)
superoxide  (ISO)
tacrine  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP,ISO)
tandospirone citrate  (ISO)
Tanshinone I  (ISO)
taurine  (EXP)
taurolithocholic acid  (ISO)
tauroursodeoxycholic acid  (ISO)
tebufenpyrad  (ISO)
telmisartan  (EXP)
terbufos  (ISO)
terbutaline  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (EXP)
tetrathiomolybdate(2-)  (ISO)
tetrodotoxin  (EXP)
thalidomide  (ISO)
thapsigargin  (ISO)
theophylline  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
thiourea  (ISO)
thymol  (ISO)
thymol sulfate(1-)  (ISO)
thymoquinone  (EXP)
titanium dioxide  (EXP,ISO)
tocopherol  (ISO)
toluene  (ISO)
topotecan  (EXP,ISO)
torcetrapib  (ISO)
toremifene  (ISO)
trans-stilbene-4,4'-diol  (ISO)
transplatin  (EXP,ISO)
tranylcypromine  (EXP)
triacsin C  (ISO)
triazolam  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP,ISO)
Tropicamide  (EXP)
trovafloxacin  (ISO)
tubocurarine  (ISO)
tungsten  (EXP,ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (EXP,ISO)
U-73122  (EXP)
uranium atom  (ISO)
urethane  (EXP,ISO)
Ursonic acid  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP)
vanadyl sulfate  (ISO)
vancomycin  (ISO)
vanoxerine dihydrochloride  (EXP)
verapamil  (ISO)
veratridine  (EXP,ISO)
vinclozolin  (EXP)
vincristine  (EXP)
vitamin D  (ISO)
vitamin E  (ISO)
WIN 55212-2  (ISO)
wortmannin  (EXP,ISO)
xanomeline  (EXP)
Xanthatin  (ISO)
xanthohumol  (ISO)
xanthones  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (EXP,ISO)
zonisamide  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to cadmium ion  (ISO)
cellular response to calcium ion  (ISO)
cellular response to epidermal growth factor stimulus  (IEP)
cellular response to hormone stimulus  (IEP)
cellular response to hypoxia  (IEP)
cellular response to parathyroid hormone stimulus  (IEP)
cellular response to phorbol 13-acetate 12-myristate  (IEP)
cellular response to prolactin  (IEP)
cellular response to reactive oxygen species  (ISO)
cellular response to transforming growth factor beta stimulus  (IEP)
cellular response to tumor necrosis factor  (IEP)
cellular response to zinc ion starvation  (IEP)
cerebral cortex development  (IMP)
conditioned taste aversion  (IEP)
female pregnancy  (IEP)
mononuclear cell differentiation  (IEP)
myoblast proliferation  (IEP)
nervous system development  (ISO)
neuron differentiation  (IMP)
osteoclast differentiation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of miRNA transcription  (IDA,ISO)
positive regulation of osteoclast differentiation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of gene expression  (ISO)
regulation of transcription by RNA polymerase II  (IBA,ISO)
response to activity  (IEP)
response to cAMP  (IEP)
response to corticosterone  (IEP)
response to cytokine  (IEP)
response to ethanol  (IEP)
response to gravity  (IEP)
response to immobilization stress  (IEP)
response to insulin  (IEP)
response to light stimulus  (IEP)
response to lipopolysaccharide  (IEP)
response to mechanical stimulus  (IEP)
response to muscle stretch  (ISO)
response to organic cyclic compound  (IEP)
response to progesterone  (IEP)
response to steroid hormone  (IEP)
response to toxic substance  (IEP)
response to xenobiotic stimulus  (IEP,ISO)
skeletal muscle cell differentiation  (ISO)
skeletal muscle cell proliferation  (IEP)
SMAD protein signal transduction  (ISO)
transcription by RNA polymerase II  (IMP,ISO)
transforming growth factor beta receptor signaling pathway  (ISO)

Cellular Component

References

References - curated
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61. Mild stress sensitizes the brain's response to morphine. Mayer P, etal., Brain Res Mol Brain Res. 2002 Aug 15;104(2):143-7. doi: 10.1016/s0169-328x(02)00330-3.
62. Alcohol Induces Parallel Changes in Hippocampal Histone H3 Phosphorylation and c-Fos Protein Expression in Male Rats. McClain JA and Nixon K, Alcohol Clin Exp Res. 2016 Jan;40(1):102-12. doi: 10.1111/acer.12933.
63. Impaired activation of AP-1 and altered expression of constituent proteins in rat adrenal during ageing. Medicherla R, etal., Mech Ageing Dev. 2001 Aug;122(11):1169-86.
64. Rapid effects of triiodothyronine on immediate-early gene expression in Schwann cells. Mercier G, etal., Glia. 2001 Aug;35(2):81-9.
65. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
66. Central administration of galanin N-terminal fragment 1-15 decreases the voluntary alcohol intake in rats. Millón C, etal., Addict Biol. 2019 Jan;24(1):76-87. doi: 10.1111/adb.12582. Epub 2017 Dec 6.
67. c-fos and cleaved caspase-3 expression after perinatal exposure to ethanol, cocaine, or the combination of both drugs. Mitchell ES and Snyder-Keller A, Brain Res Dev Brain Res. 2003 Dec 30;147(1-2):107-17. doi: 10.1016/j.devbrainres.2003.08.010.
68. Differential expression of activator protein-1 transcription factors in pregnant rat myometrium. Mitchell JA and Lye SJ, Biol Reprod. 2002 Jul;67(1):240-6.
69. Mechanical stretch and progesterone differentially regulate activator protein-1 transcription factors in primary rat myometrial smooth muscle cells. Mitchell JA, etal., Am J Physiol Endocrinol Metab. 2004 Sep;287(3):E439-45. Epub 2004 May 4.
70. Inducible-NOS but not neuronal-NOS participate in the acute effect of TNF-alpha on hypothalamic insulin-dependent inhibition of food intake. Moraes JC, etal., FEBS Lett. 2006 Aug 21;580(19):4625-31. doi: 10.1016/j.febslet.2006.07.042. Epub 2006 Jul 21.
71. Male rats exposed to cocaine in utero demonstrate elevated expression of Fos in the prefrontal cortex in response to environment. Morrow BA, etal., Neuropsychopharmacology 2002 Mar;26(3):275-85.
72. Proto-oncogene c-fos induction in thiamine-deficient encephalopathy. Protective effects of nicardipine on pyrithiamine-induced lesions. Munujos P, etal., J Neurol Sci. 1993 Sep;118(2):175-80. doi: 10.1016/0022-510x(93)90107-a.
73. Pregnenolone sulfate activates basic region leucine zipper transcription factors in insulinoma cells: role of voltage-gated Ca2+ channels and transient receptor potential melastatin 3 channels. Müller I, etal., Mol Pharmacol. 2011 Dec;80(6):1179-89. doi: 10.1124/mol.111.074781. Epub 2011 Sep 23.
74. Renal ischemia-induced cholesterol loading: transcription factor recruitment and chromatin remodeling along the HMG CoA reductase gene. Naito M, etal., Am J Pathol. 2009 Jan;174(1):54-62. doi: 10.2353/ajpath.2009.080602. Epub 2008 Dec 18.
75. Fos induction in the amygdala by vestibular information during hypergravity stimulation. Nakagawa A, etal., Brain Res 2003 Oct 3;986(1-2):114-23.
76. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
77. Modulation of c-myc and c-fos gene expression in regenerating rat liver by 2-mercaptopropionylglycine. Ohri S, etal., Cell Biol Int 2002;26(2):187-92.
78. Expressions of junB and c-fos are enhanced in 4-nitroquinoline 1-oxide-induced rat tongue cancers. Ohyama M, etal., Pathol Int. 2004 Jan;54(1):35-40.
79. Differential expression of c-fos and tyrosine hydroxylase mRNA in the adrenal gland of the infant rat: evidence for an adrenal hyporesponsive period. Okimoto DK, etal., Endocrinology 2002 May;143(5):1717-25.
80. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
81. Strain differences in Fos expression following airpuff startle in Spontaneously Hypertensive and Wistar Kyoto rats. Palmer AA and Printz MP, Neuroscience 1999 Mar;89(3):965-78.
82. Knockdown of c-Fos suppresses the growth of human colon carcinoma cells in athymic mice. Pandey MK, etal., Int J Cancer. 2012 Jan 1;130(1):213-22. doi: 10.1002/ijc.25997. Epub 2011 Apr 8.
83. Experience-dependent decrease in synaptically localized Fra-1. Paratcha G, etal., Brain Res Mol Brain Res. 2000 May 31;78(1-2):120-30.
84. Distribution of c-Fos immunoreactivity in the rat brain following abuse-like toluene vapor inhalation. Perit KE, etal., Neurotoxicol Teratol. 2012 Jan-Feb;34(1):37-46. doi: 10.1016/j.ntt.2011.10.007. Epub 2011 Oct 30.
85. Neural substrate of nicotine addiction as defined by functional brain maps of gene expression. Pich EM, etal., J Physiol Paris. 1998 Jun-Aug;92(3-4):225-8. doi: 10.1016/s0928-4257(98)80015-6.
86. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
87. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
88. Contribution of REM sleep to Fos and FRA expression in the vestibular nuclei of rat leading to vestibular adaptation during the STS-90 Neurolab Mission. Pompeiano O Arch Ital Biol. 2007 Jan;145(1):55-85.
89. Cell selective induction and transcriptional activation of immediate early genes by hypoxia. Prabhakar NR, etal., Brain Res. 1995 Oct 30;697(1-2):266-70. doi: 10.1016/0006-8993(95)00994-2.
90. Constitutive activation of transcription factor AP-1 in cervical cancer and suppression of human papillomavirus (HPV) transcription and AP-1 activity in HeLa cells by curcumin. Prusty BK and Das BC, Int J Cancer. 2005 Mar 1;113(6):951-60.
91. Reduced adrenal activation in a rat line selected for high alcohol sensitivity. Raatesalmi K, etal., Alcohol Clin Exp Res. 2002 Sep;26(9):1344-9. doi: 10.1097/01.ALC.0000030560.28034.5D.
92. GOA pipeline RGD automated data pipeline
93. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
94. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
95. Expression of transcription factors CREB and c-Fos in the brains of terminal Creutzfeldt-Jakob disease cases. Rodriguez A and Ferrer I, Neurosci Lett. 2007 Jun 21;421(1):10-5. Epub 2007 May 4.
96. The moonlighting protein c-Fos activates lipid synthesis in neurons, an activity that is critical for cellular differentiation and cortical development. Rodríguez-Berdini L, etal., J Biol Chem. 2020 Jun 26;295(26):8808-8818. doi: 10.1074/jbc.RA119.010129. Epub 2020 May 8.
97. Amphetamine and pseudoephedrine cross-tolerance measured by c-Fos protein expression in brains of chronically treated rats. Ruksee N, etal., BMC Neurosci. 2008 Oct 6;9:99. doi: 10.1186/1471-2202-9-99.
98. ITF expression in mouse brain during acquisition of alcohol self-administration. Ryabinin AE, etal., Brain Res. 2001 Jan 26;890(1):192-5. doi: 10.1016/s0006-8993(00)03251-0.
99. Regulation of AP1 (Jun/Fos) factor expression and activation in ovarian granulosa cells. Relation of JunD and Fra2 to terminal differentiation. Sharma SC and Richards JS, J Biol Chem. 2000 Oct 27;275(43):33718-28.
100. Involvement of AMPA/Kainate Glutamate Receptor in the Extinction and Reinstatement of Morphine-Induced Conditioned Place Preference: A Behavioral and Molecular Study. Siahposht-Khachaki A, etal., Cell Mol Neurobiol. 2017 Mar;37(2):315-328. doi: 10.1007/s10571-016-0371-2. Epub 2016 Apr 6.
101. Effect of postnatal treadmill exercise on c-Fos expression in the hippocampus of rat pups born from the alcohol-intoxicated mothers. Sim YJ, etal., Brain Dev. 2008 Feb;30(2):118-25. doi: 10.1016/j.braindev.2007.07.003. Epub 2007 Aug 27.
102. Improved survival in patients with advanced colorectal carcinoma failing 5-fluorouracil who received irinotecan hydrochloride and have high intratumor C-fos expression. Singh A, etal., Am J Clin Oncol. 1998 Oct;21(5):466-9.
103. Effects of all-trans retinoic acid as a potential chemopreventive agent on the formation of azoxymethane-induced aberrant crypt foci: differential expression of c-myc and c-fos MRNA and protein. Stopera SA and Bird RP, Int J Cancer. 1993 Mar 12;53(5):798-803.
104. Colonic aberrant crypt foci are associated with increased expression of c-fos: the possible role of modified c-fos expression in preneoplastic lesions in colon cancer. Stopera SA, etal., Carcinogenesis. 1992 Apr;13(4):573-8.
105. Activation of the cAMP pathway synergistically increases IL-1-induced IL-6 gene expression in FRTL-5 thyroid cells: involvement of AP-1 transcription factors. Szabo-Fresnais N, etal., Mol Cell Endocrinol. 2008 Mar 12;284(1-2):28-37. Epub 2008 Jan 8.
106. Differential activation of c‑Fos in the paraventricular nuclei of the hypothalamus and thalamus following myocardial infarction in rats. Tae HJ, etal., Mol Med Rep. 2016 Oct;14(4):3503-8. doi: 10.3892/mmr.2016.5731. Epub 2016 Sep 7.
107. Endogenous prolactin-releasing peptide regulates food intake in rodents. Takayanagi Y, etal., J Clin Invest. 2008 Dec;118(12):4014-24. doi: 10.1172/JCI34682. Epub 2008 Nov 3.
108. Suppression of c-fos induction in the nucleus accumbens prevents acquisition but not expression of morphine-conditioned place preference. Tolliver BK, etal., Eur J Neurosci. 2000 Sep;12(9):3399-406. doi: 10.1046/j.1460-9568.2000.00214.x.
109. Colonic inflammation induces fos expression in the thoracolumbar spinal cord increasing activity in the spinoparabrachial pathway. Traub RJ and Murphy A, Pain 2002 Jan;95(1-2):93-102.
110. JNK signalling regulates antioxidant responses in neurons. Ugbode C, etal., Redox Biol. 2020 Oct;37:101712. doi: 10.1016/j.redox.2020.101712. Epub 2020 Sep 4.
111. Transient expression of E1A and Ras oncogenes causes downregulation of c-fos gene transcription in nontransformed REF52 cells. Usenko T, etal., Oncogene 2003 Oct 23;22(48):7661-6.
112. Basic fibroblast growth factor stimulates collagenase-3 promoter activity in osteoblasts through an activator protein-1-binding site. Varghese S, etal., Endocrinology. 2000 Jun;141(6):2185-91.
113. Chronic alcohol intake reduces retinoic acid concentration and enhances AP-1 (c-Jun and c-Fos) expression in rat liver. Wang XD, etal., Hepatology. 1998 Sep;28(3):744-50. doi: 10.1002/hep.510280321.
114. Different pattern of brain c-Fos expression following re-exposure to ethanol or sucrose self-administration environment. Wedzony K, etal., Naunyn Schmiedebergs Arch Pharmacol. 2003 Nov;368(5):331-41. doi: 10.1007/s00210-003-0811-7. Epub 2003 Oct 22.
115. Restraint-induced fra-2 and c-fos expression in the rat forebrain: relationship to stress duration. Weinberg MS, etal., Neuroscience. 2007 Dec 5;150(2):478-86. Epub 2007 Sep 14.
116. Cardiac gene expression profile in rats with terminal heart failure and cachexia. Wellner M, etal., Physiol Genomics. 2005 Feb 10;20(3):256-67. Epub 2004 Dec 28.
117. Binge ethanol effects on prefrontal cortex neurons, spatial working memory and task-induced neuronal activation in male and female rats. West RK, etal., Physiol Behav. 2018 May 1;188:79-85. doi: 10.1016/j.physbeh.2018.01.027. Epub 2018 Jan 31.
118. Gender-specific effects of social housing on chronic stress-induced limbic Fos expression. Westenbroek C, etal., Neuroscience 2003;121(1):189-99.
119. The galanin receptor-3 antagonist, SNAP 37889, inhibits cue-induced reinstatement of alcohol-seeking and increases c-Fos expression in the nucleus accumbens shell of alcohol-preferring rats. Wilson KE, etal., J Psychopharmacol. 2018 Aug;32(8):911-921. doi: 10.1177/0269881118780015. Epub 2018 Jun 21.
120. The differential molecular mechanisms underlying proenkephalin mRNA expression induced by forskolin and phorbol-12-myristic-13-acetate in primary cultured astrocytes. Won JS and Suh HW, Brain Res Mol Brain Res. 2000 Dec 8;84(1-2):41-51.
121. The comparative analysis of proenkephalin mRNA expression induced by cholera toxin and pertussis toxin in primary cultured rat cortical astrocytes. Won JS and Suh HW, Brain Res Mol Brain Res. 2001 Mar 31;88(1-2):83-93.
122. Alterations of estradiol-induced histone H3 acetylation in the preoptic area and anteroventral periventricular nucleus of middle-aged female rats. Xu W, etal., Biochem Biophys Res Commun. 2019 Aug 27;516(3):894-899. doi: 10.1016/j.bbrc.2019.06.145. Epub 2019 Jul 1.
123. Vesicular glutamate transporter-3 contributes to visceral hyperalgesia induced by Trichinella spiralis infection in rats. Yang CQ, etal., Dig Dis Sci. 2012 Apr;57(4):865-72. doi: 10.1007/s10620-011-1970-x. Epub 2011 Dec 9.
124. Paecilomycies japonica reduces repeated nicotine-induced neuronal and behavioral activation in rats. Ye M, etal., BMC Complement Altern Med. 2015 Jul 14;15:227. doi: 10.1186/s12906-015-0739-8.
125. Target organ protection from a novel angiotensin II receptor (AT1) vaccine ATR12181 in spontaneously hypertensive rats. Zhu F, etal., Cell Mol Immunol. 2006 Apr;3(2):107-14.
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Genomics

Comparative Map Data
Fos
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86110,852,188 - 110,855,054 (+)NCBIGRCr8
mRatBN7.26105,121,170 - 105,124,036 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6105,121,170 - 105,124,036 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6105,290,640 - 105,293,508 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06105,589,531 - 105,592,399 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06104,959,176 - 104,962,044 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06109,300,433 - 109,303,299 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6109,300,433 - 109,303,299 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06116,249,742 - 116,252,608 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46109,559,135 - 109,562,001 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16109,562,609 - 109,566,002 (+)NCBI
Celera6102,942,464 - 102,945,330 (+)NCBICelera
Cytogenetic Map6q31NCBI
FOS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381475,278,828 - 75,282,230 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1475,278,826 - 75,282,230 (+)EnsemblGRCh38hg38GRCh38
GRCh371475,745,531 - 75,748,933 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361474,815,284 - 74,818,666 (+)NCBINCBI36Build 36hg18NCBI36
Build 341474,815,283 - 74,818,666NCBI
Celera1455,783,567 - 55,787,023 (+)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1455,913,924 - 55,917,380 (+)NCBIHuRef
CHM1_11475,683,266 - 75,686,721 (+)NCBICHM1_1
T2T-CHM13v2.01469,488,228 - 69,491,630 (+)NCBIT2T-CHM13v2.0
Fos
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391285,520,664 - 85,524,048 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1285,520,664 - 85,524,047 (+)EnsemblGRCm39 Ensembl
GRCm381285,473,890 - 85,477,274 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1285,473,890 - 85,477,273 (+)EnsemblGRCm38mm10GRCm38
MGSCv371286,814,851 - 86,818,219 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361286,363,004 - 86,366,372 (+)NCBIMGSCv36mm8
Celera1286,933,225 - 86,936,593 (+)NCBICelera
Cytogenetic Map12D2NCBI
cM Map1239.7NCBI
Fos
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955523305,728 - 310,728 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955523307,181 - 310,728 (-)NCBIChiLan1.0ChiLan1.0
FOS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21576,362,508 - 76,366,629 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11475,579,607 - 75,583,133 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01455,832,570 - 55,835,984 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11474,676,316 - 74,679,766 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1474,676,316 - 74,679,766 (+)Ensemblpanpan1.1panPan2
FOS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1848,330,856 - 48,334,273 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl848,331,026 - 48,333,467 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha848,014,730 - 48,018,137 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0848,558,356 - 48,561,763 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl848,558,343 - 48,561,758 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1848,229,017 - 48,232,423 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0848,250,295 - 48,253,702 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0848,649,028 - 48,652,435 (+)NCBIUU_Cfam_GSD_1.0
Fos
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864027,680,843 - 27,684,228 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364884,384,705 - 4,388,122 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364884,384,710 - 4,388,118 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl798,449,349 - 98,455,554 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1798,449,508 - 98,451,971 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27104,293,828 - 104,296,291 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FOS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12452,497,465 - 52,501,161 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2452,497,521 - 52,501,514 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605340,725,132 - 40,728,594 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fos
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473426,423,079 - 26,427,732 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473426,424,053 - 26,427,431 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fos
10 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:143
Count of miRNA genes:105
Interacting mature miRNAs:116
Transcripts:ENSRNOT00000010712
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)683190345106747639Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat

Markers in Region
Fos  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26105,122,222 - 105,122,470 (+)MAPPERmRatBN7.2
Rnor_6.06109,301,486 - 109,301,733NCBIRnor6.0
Rnor_5.06116,251,308 - 116,251,555UniSTSRnor5.0
RGSC_v3.46109,560,188 - 109,560,435UniSTSRGSC3.4
Celera6102,943,517 - 102,943,764UniSTS
Cytogenetic Map6q31UniSTS
WI-19801  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26105,123,847 - 105,124,149 (+)MAPPERmRatBN7.2
Rnor_6.06109,303,111 - 109,303,412NCBIRnor6.0
Rnor_5.06116,249,629 - 116,249,930UniSTSRnor5.0
RGSC_v3.46109,561,813 - 109,562,114UniSTSRGSC3.4
Celera6102,945,142 - 102,945,443UniSTS
Cytogenetic Map6q31UniSTS
PMC151804P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26105,122,906 - 105,123,431 (+)MAPPERmRatBN7.2
Rnor_6.06109,302,170 - 109,302,694NCBIRnor6.0
Rnor_5.06116,250,347 - 116,250,871UniSTSRnor5.0
RGSC_v3.46109,560,872 - 109,561,396UniSTSRGSC3.4
Celera6102,944,201 - 102,944,725UniSTS
Cytogenetic Map6q31UniSTS
PMC108124P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26105,122,435 - 105,123,350 (+)MAPPERmRatBN7.2
Rnor_6.06109,301,699 - 109,302,613NCBIRnor6.0
Rnor_5.06116,250,428 - 116,251,342UniSTSRnor5.0
RGSC_v3.46109,560,401 - 109,561,315UniSTSRGSC3.4
Celera6102,943,730 - 102,944,644UniSTS
Cytogenetic Map6q31UniSTS
PMC321436P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26105,122,914 - 105,123,136 (+)MAPPERmRatBN7.2
Rnor_6.06109,302,178 - 109,302,399NCBIRnor6.0
Rnor_5.06116,250,642 - 116,250,863UniSTSRnor5.0
RGSC_v3.46109,560,880 - 109,561,101UniSTSRGSC3.4
Celera6102,944,209 - 102,944,430UniSTS
Cytogenetic Map6q31UniSTS
PMC99986P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26105,120,896 - 105,121,180 (+)MAPPERmRatBN7.2
Rnor_6.06109,300,160 - 109,300,443NCBIRnor6.0
Rnor_5.06116,252,598 - 116,252,881UniSTSRnor5.0
RGSC_v3.46109,558,862 - 109,559,145UniSTSRGSC3.4
Celera6102,942,191 - 102,942,474UniSTS
Cytogenetic Map6q31UniSTS
BP240034A10G4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26105,124,058 - 105,124,364 (+)MAPPERmRatBN7.2
Rnor_6.06109,303,322 - 109,303,627NCBIRnor6.0
Rnor_5.06116,249,414 - 116,249,719UniSTSRnor5.0
RGSC_v3.46109,562,024 - 109,562,329UniSTSRGSC3.4
Celera6102,945,353 - 102,945,658UniSTS
Cytogenetic Map6q31UniSTS
Fos  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26105,124,316 - 105,124,496 (+)MAPPERmRatBN7.2
Rnor_6.06109,303,580 - 109,303,759NCBIRnor6.0
Rnor_5.06116,249,282 - 116,249,461UniSTSRnor5.0
RGSC_v3.46109,562,282 - 109,562,461UniSTSRGSC3.4
Celera6102,945,611 - 102,945,790UniSTS
Cytogenetic Map6q31UniSTS
Fos  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26105,124,370 - 105,124,546 (+)MAPPERmRatBN7.2
Rnor_6.06109,303,634 - 109,303,809NCBIRnor6.0
Rnor_5.06116,249,232 - 116,249,407UniSTSRnor5.0
RGSC_v3.46109,562,336 - 109,562,511UniSTSRGSC3.4
Celera6102,945,665 - 102,945,840UniSTS
Cytogenetic Map6q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 3 15 7 6
Low 43 41 25 16 25 8 11 53 35 32 5 8
Below cutoff 16 16 16 6 2

Sequence


RefSeq Acc Id: ENSRNOT00000010712   ⟹   ENSRNOP00000010712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6105,121,170 - 105,124,036 (+)Ensembl
Rnor_6.0 Ensembl6109,300,433 - 109,303,299 (+)Ensembl
RefSeq Acc Id: NM_022197   ⟹   NP_071533
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86110,852,188 - 110,855,054 (+)NCBI
mRatBN7.26105,121,170 - 105,124,036 (+)NCBI
Rnor_6.06109,300,433 - 109,303,299 (+)NCBI
Rnor_5.06116,249,742 - 116,252,608 (-)NCBI
RGSC_v3.46109,559,135 - 109,562,001 (+)RGD
Celera6102,942,464 - 102,945,330 (+)RGD
Sequence:
RefSeq Acc Id: NP_071533   ⟸   NM_022197
- UniProtKB: Q4FDN1 (UniProtKB/Swiss-Prot),   P12841 (UniProtKB/Swiss-Prot),   A6JE29 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000010712   ⟸   ENSRNOT00000010712
Protein Domains
bZIP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P12841-F1-model_v2 AlphaFold P12841 1-380 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694742
Promoter ID:EPDNEW_R5267
Type:single initiation site
Name:Fos_1
Description:Fos proto-oncogene, AP-1 transcription factor subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06109,300,435 - 109,300,495EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2626 AgrOrtholog
BioCyc Gene G2FUF-36778 BioCyc
Ensembl Genes ENSRNOG00000008015 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055025291 UniProtKB/Swiss-Prot
  ENSRNOG00060023383 UniProtKB/Swiss-Prot
  ENSRNOG00065024997 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010712 ENTREZGENE
  ENSRNOT00000010712.4 UniProtKB/Swiss-Prot
  ENSRNOT00055043608 UniProtKB/Swiss-Prot
  ENSRNOT00060040477 UniProtKB/Swiss-Prot
  ENSRNOT00065042954 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AP-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:314322 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene Fos ENTREZGENE
PANTHER PTHR23351 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23351:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam bZIP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fos PhenoGen
PRINTS LEUZIPPRFOS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BZIP_BASIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008015 RatGTEx
  ENSRNOG00055025291 RatGTEx
  ENSRNOG00060023383 RatGTEx
  ENSRNOG00065024997 RatGTEx
SMART BRLZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57959 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6JE29 ENTREZGENE, UniProtKB/TrEMBL
  A6JE31_RAT UniProtKB/TrEMBL
  FOS_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4FDN1 ENTREZGENE
  Q5G6W2_RAT UniProtKB/TrEMBL
  Q5G6W3_RAT UniProtKB/TrEMBL
  Q5U7E3_RAT UniProtKB/TrEMBL
  Q5U873_RAT UniProtKB/TrEMBL
  Q5U874_RAT UniProtKB/TrEMBL
  Q5U875_RAT UniProtKB/TrEMBL
UniProt Secondary Q4FDN1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-07 Fos  Fos proto-oncogene, AP-1 transcription factor subunit  Fos  FBJ osteosarcoma oncogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Fos  FBJ osteosarcoma oncogene  Fos  FBJ murine osteosarcoma viral oncogene homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-02-28 Fos  FBJ murine osteosarcoma viral oncogene homolog  c-fos  c-fos oncogene  Data merged from RGD:735054 737654 APPROVED
2005-01-20 Fos  FBJ murine osteosarcoma viral oncogene homolog    v-fos FBJ murine osteosarcoma viral oncogene homolog  Name updated 1299863 APPROVED
2002-06-10 Fos  v-fos FBJ murine osteosarcoma viral oncogene homolog      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_function may play a role in androgen regulated apoptosis 70259
gene_physical_interaction forms heterodimeric complexes with proteins of the Jun family which then bind to the AP-1 gene promoter site to regulate gene expression 1302797
gene_process increases the intracellular calcium ion levels which helps in the degradation of phosphatidyl inositol and activation of protein kinase C 70259
gene_process increases transcription associated with cell death in prostate regression 70259
gene_regulation expression is induced in response to airpuff startle in hypothalamus, thalamus, midbrain, pons and medulla 1358971