Fmo1 (flavin containing dimethylaniline monoxygenase 1) - Rat Genome Database

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Gene: Fmo1 (flavin containing dimethylaniline monoxygenase 1) Rattus norvegicus
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Symbol: Fmo1
Name: flavin containing dimethylaniline monoxygenase 1
RGD ID: 2622
Description: Enables N,N-dimethylaniline monooxygenase activity and trimethylamine monooxygenase activity. Involved in response to lipopolysaccharide. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human FMO1 (flavin containing dimethylaniline monoxygenase 1); PARTICIPATES IN tamoxifen pharmacodynamics pathway; tamoxifen pharmacokinetics pathway; phase I biotransformation pathway via cytochrome P450; INTERACTS WITH (+)-schisandrin B; (R,R,R)-alpha-tocopherol; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: dimethylaniline monooxygenase [N-oxide-forming] 1; dimethylaniline oxidase 1; flavin containing monooxygenase 1; Flavin-containing monooxygenase 1; FMO 1; hepatic flavin-containing monooxygenase 1; RFMO1A; trimethylamine monooxygenase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81377,715,405 - 77,747,666 (-)NCBIGRCr8
mRatBN7.21375,182,184 - 75,214,439 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1375,182,176 - 75,214,647 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1377,760,307 - 77,792,478 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01379,060,879 - 79,093,009 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01376,320,740 - 76,352,870 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01380,712,885 - 80,745,095 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1380,712,882 - 80,745,347 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01385,607,539 - 85,639,778 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41378,503,770 - 78,536,359 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11378,517,957 - 78,550,547 (-)NCBI
Celera1374,919,415 - 74,951,610 (-)NCBICelera
Cytogenetic Map13q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Fmo1Rat1q24 Deletion Syndrome  ISOFMO1 (Homo sapiens)8554872ClinVar Annotator: match by term: 1q24q25 microdeletion syndromeClinVarPMID:25741868
Fmo1Ratgastrointestinal stromal tumor  ISOFMO1 (Homo sapiens)8554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
Fmo1Ratparathyroid carcinoma  ISOFMO1 (Homo sapiens)8554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532
Object Symbol
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Reference
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Original Reference(s)
Fmo1Ratamyotrophic lateral sclerosis type 1  ISOFMO1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17127561
Fmo1Ratautism spectrum disorder  ISOFMO1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35663546
Fmo1RatExperimental Liver Cirrhosis  ISOFMO1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17072980 and PMID:25380136

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Object Symbol
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Original Reference(s)
Fmo1Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of FMO1 mRNA]CTDPMID:31150632
Fmo1Rat(R,R,R)-alpha-tocopherol increases expressionEXP 6480464alpha-Tocopherol results in increased expression of FMO1 mRNACTDPMID:16908007
Fmo1Rat1,1-dichloroethene decreases expressionISOFmo1 (Mus musculus)6480464vinylidene chloride results in decreased expression of FMO1 mRNACTDPMID:26682919
Fmo1Rat1,2-dimethylhydrazine decreases expressionISOFmo1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of FMO1 mRNACTDPMID:22206623
Fmo1Rat1-naphthyl isothiocyanate decreases expressionEXP 64804641-Naphthylisothiocyanate results in decreased expression of FMO1 mRNACTDPMID:17522070 more ...
Fmo1Rat1-naphthyl isothiocyanate decreases expressionISOFmo1 (Mus musculus)64804641-Naphthylisothiocyanate results in decreased expression of FMO1 mRNACTDPMID:15913567
Fmo1Rat17alpha-ethynylestradiol affects expressionISOFmo1 (Mus musculus)6480464Ethinyl Estradiol affects the expression of FMO1 mRNACTDPMID:17555576
Fmo1Rat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of FMO1 mRNA and Estradiol results in decreased expression of FMO1 proteinCTDPMID:21966433 and PMID:24894866
Fmo1Rat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of FMO1 mRNACTDPMID:32145629
Fmo1Rat17beta-estradiol decreases expressionISOFmo1 (Mus musculus)6480464Estradiol results in decreased expression of FMO1 mRNACTDPMID:14664709 and PMID:39298647
Fmo1Rat17beta-estradiol multiple interactionsEXP 6480464resveratrol inhibits the reaction [Estradiol results in decreased expression of FMO1 mRNA] and resveratrol inhibits the reaction [Estradiol results in decreased expression of FMO1]CTDPMID:24894866
Fmo1Rat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsEXP 6480464[3 more ...CTDPMID:16984957
Fmo1Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionEXP 64804642 more ...CTDPMID:21394737
Fmo1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOFmo1 (Mus musculus)6480464[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of FMO1 mRNA and [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of FMO1 mRNACTDPMID:16214954 and PMID:25975270
Fmo1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOFmo1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of FMO1 mRNACTDPMID:21570461 and PMID:26377647
Fmo1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of FMO1 mRNACTDPMID:11752688 more ...
Fmo1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of FMO1 mRNACTDPMID:22298810
Fmo1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOFmo1 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of FMO1 mRNACTDPMID:18765683 more ...
Fmo1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOFmo1 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of FMO1 mRNACTDPMID:19933214 and PMID:28922406
Fmo1Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of FMO1 mRNACTDPMID:21346803

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Biological Process
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Original Reference(s)
Fmo1Ratenergy homeostasis acts_upstream_of_or_withinIEAUniProtKB:P50285 and ensembl:ENSMUSP000000372591600115GO_REF:0000107EnsemblGO_REF:0000107
Fmo1Ratenergy homeostasis acts_upstream_of_or_withinISOFmo1 (Mus musculus)1624291MGI:1916776 more ...RGDPMID:24792439
Fmo1Ratnegative regulation of fatty acid oxidation acts_upstream_of_or_withinISOFmo1 (Mus musculus)1624291MGI:1916776 more ...RGDPMID:24792439
Fmo1Ratnegative regulation of fatty acid oxidation acts_upstream_of_or_withinIEAUniProtKB:P50285 and ensembl:ENSMUSP000000372591600115GO_REF:0000107EnsemblGO_REF:0000107
Fmo1Ratorganic acid metabolic process involved_inISOFMO1 (Homo sapiens)1624291 PMID:15144220RGDPMID:15144220
Fmo1Ratorganic acid metabolic process involved_inIEAUniProtKB:Q01740 and ensembl:ENSP000004817321600115GO_REF:0000107EnsemblGO_REF:0000107
Fmo1Ratorganic acid metabolic process involved_inISOFMO1 (Sus scrofa)1624291 PMID:15144220RGDPMID:15144220
Fmo1Ratresponse to lipopolysaccharide  IEP 2316301 RGD 
Fmo1Rattaurine biosynthetic process involved_inISOFMO1 (Homo sapiens)1624291 PMID:32156684RGDPMID:32156684
Fmo1Rattaurine biosynthetic process involved_inIEAUniProtKB:Q01740 and ensembl:ENSP000004817321600115GO_REF:0000107EnsemblGO_REF:0000107
Fmo1Rattaurine biosynthetic process involved_inIEAUniProtKB:P50285 and ensembl:ENSMUSP000000372591600115GO_REF:0000107EnsemblGO_REF:0000107
Fmo1Rattaurine biosynthetic process involved_inISOFmo1 (Mus musculus)1624291 PMID:32156684RGDPMID:32156684
Fmo1Rattaurine biosynthetic process involved_inISSUniProtKB:Q017401600115GO_REF:0000024UniProtGO_REF:0000024
Fmo1Rattoxin metabolic process involved_inISOFMO1 (Homo sapiens)1624291 PMID:15144220RGDPMID:15144220
Fmo1Rattoxin metabolic process involved_inIEAUniProtKB:Q01740 and ensembl:ENSP000004817321600115GO_REF:0000107EnsemblGO_REF:0000107
Fmo1Rattoxin metabolic process involved_inISOFMO1 (Sus scrofa)1624291 PMID:15144220RGDPMID:15144220
Fmo1Ratxenobiotic metabolic process acts_upstream_of_or_withinIEAUniProtKB:P50285 and ensembl:ENSMUSP000000372591600115GO_REF:0000107EnsemblGO_REF:0000107
Fmo1Ratxenobiotic metabolic process acts_upstream_of_or_withinISOFmo1 (Mus musculus)1624291MGI:5487815 PMID:19262426RGDPMID:19262426
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Cellular Component

  
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Original Reference(s)
Fmo1Ratendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
Fmo1Ratendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-00971600115GO_REF:0000044UniProtGO_REF:0000044
Fmo1Ratendoplasmic reticulum membrane located_inIEAUniRule:UR0000119491600115GO_REF:0000104UniProtGO_REF:0000104
Fmo1Ratendoplasmic reticulum membrane located_inISOFMO1 (Sus scrofa)1624291 PMID:7758472RGDPMID:7758472
Fmo1Ratendoplasmic reticulum membrane located_inISSUniProtKB:Q95LA21600115GO_REF:0000024UniProtGO_REF:0000024
Fmo1Ratendoplasmic reticulum membrane located_inISOFMO1 (Canis lupus familiaris)1624291 PMID:11792679RGDPMID:11792679
Fmo1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043

Molecular Function
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Original Reference(s)
Fmo1Ratflavin adenine dinucleotide binding enablesIEAInterPro:IPR000960 and InterPro:IPR0209461600115GO_REF:0000002InterProGO_REF:0000002
Fmo1Rathypotaurine monooxygenase activity enablesISOFMO1 (Homo sapiens)1624291 PMID:32156684RGDPMID:32156684
Fmo1Rathypotaurine monooxygenase activity enablesIEARHEA:698191600115GO_REF:0000116RHEAGO_REF:0000116
Fmo1Rathypotaurine monooxygenase activity enablesIEAUniProtKB:P50285 and ensembl:ENSMUSP000000372591600115GO_REF:0000107EnsemblGO_REF:0000107
Fmo1Rathypotaurine monooxygenase activity enablesIEAUniProtKB:Q01740 and ensembl:ENSP000004817321600115GO_REF:0000107EnsemblGO_REF:0000107
Fmo1Rathypotaurine monooxygenase activity enablesISOFmo1 (Mus musculus)1624291 PMID:32156684RGDPMID:32156684
Fmo1Rathypotaurine monooxygenase activity enablesISSUniProtKB:Q017401600115GO_REF:0000024UniProtGO_REF:0000024
Fmo1Ratmonooxygenase activity enablesISOFMO1 (Homo sapiens)1624291 PMID:19262426RGDPMID:19262426
Fmo1Ratmonooxygenase activity  IDA 728615 RGD 
Fmo1Ratmonooxygenase activity enablesIEAUniProtKB:Q01740 and ensembl:ENSP000004817321600115GO_REF:0000107EnsemblGO_REF:0000107
Fmo1Ratmonooxygenase activity enablesIEAUniProtKB:P50285 and ensembl:ENSMUSP000000372591600115GO_REF:0000107EnsemblGO_REF:0000107
Fmo1Ratmonooxygenase activity enablesISOFmo1 (Mus musculus)1624291MGI:5487815 PMID:19262426RGDPMID:19262426
Fmo1Ratmonooxygenase activity enablesIEAUniProtKB-KW:KW-05031600115GO_REF:0000043UniProtGO_REF:0000043
Fmo1RatN,N-dimethylaniline monooxygenase activity enablesISOFMO1 (Homo sapiens)1624291 PMID:15144220RGDPMID:15144220
Fmo1RatN,N-dimethylaniline monooxygenase activity  IDA 728615 RGD 
Fmo1RatN,N-dimethylaniline monooxygenase activity enablesIEAUniProtKB:Q01740 and ensembl:ENSP000004817321600115GO_REF:0000107EnsemblGO_REF:0000107
Fmo1RatN,N-dimethylaniline monooxygenase activity enablesIEARHEA:244681600115GO_REF:0000116RHEAGO_REF:0000116
Fmo1RatN,N-dimethylaniline monooxygenase activity enablesIEAInterPro:IPR002253 and InterPro:IPR0209461600115GO_REF:0000002InterProGO_REF:0000002
Fmo1RatN,N-dimethylaniline monooxygenase activity enablesIBAPANTHER:PTN000545689 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Fmo1RatN,N-dimethylaniline monooxygenase activity enablesISOFMO1 (Sus scrofa)1624291 PMID:15144220 and PMID:7758472RGDPMID:15144220 and PMID:7758472
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Imported Annotations - SMPDB

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Original Reference(s)
Fmo1Rattamoxifen pharmacodynamics pathway   ISOFMO1 (Homo sapiens)10402751 SMPDBSMP:00471
Fmo1Rattamoxifen pharmacokinetics pathway   ISOFMO1 (Homo sapiens)10402751 SMPDBSMP:00606

Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
Fmo1Ratphase I biotransformation pathway via cytochrome P450  IEA 6907045 KEGGrno:00982

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Reference Title
Reference Citation
1. Lipopolysaccharide-induced epithelial monoamine oxidase mediates alveolar bone loss in a rat chronic wound model. Ekuni D, etal., Am J Pathol. 2009 Oct;175(4):1398-409. Epub 2009 Sep 24.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat liver flavin-containing monooxygenase (FMO): cDNA cloning and expression in yeast. Itoh K, etal., Biochim Biophys Acta 1993 May 28;1173(2):165-71.
5. Physiological factors affecting the expression of FMO1 and FMO3 in the rat liver and kidney. Lattard V, etal., Biochem Pharmacol 2002 Apr 15;63(8):1453-64.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes. Novick RM, etal., J Pharmacol Exp Ther. 2009 Jun;329(3):1148-55. Epub 2009 Mar 23.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Effect of hyperosmotic conditions on flavin-containing monooxygenase activity, protein and mRNA expression in rat kidney. Rodriguez-Fuentes G, etal., Toxicol Lett. 2009 Jun 1;187(2):115-8. Epub 2009 Feb 20.
15. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
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PMID:9094723   PMID:15144220   PMID:15465034   PMID:15489334   PMID:19262426   PMID:24440618  



Fmo1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81377,715,405 - 77,747,666 (-)NCBIGRCr8
mRatBN7.21375,182,184 - 75,214,439 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1375,182,176 - 75,214,647 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1377,760,307 - 77,792,478 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01379,060,879 - 79,093,009 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01376,320,740 - 76,352,870 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01380,712,885 - 80,745,095 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1380,712,882 - 80,745,347 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01385,607,539 - 85,639,778 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41378,503,770 - 78,536,359 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11378,517,957 - 78,550,547 (-)NCBI
Celera1374,919,415 - 74,951,610 (-)NCBICelera
Cytogenetic Map13q22NCBI
FMO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381171,248,494 - 171,285,978 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1171,248,471 - 171,285,978 (+)EnsemblGRCh38hg38GRCh38
GRCh371171,217,633 - 171,255,117 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,484,287 - 169,521,737 (+)NCBINCBI36Build 36hg18NCBI36
Build 341167,949,320 - 167,986,769NCBI
Celera1144,327,502 - 144,364,465 (+)NCBICelera
Cytogenetic Map1q24.3NCBI
HuRef1142,440,949 - 142,478,265 (+)NCBIHuRef
CHM1_11172,639,801 - 172,677,227 (+)NCBICHM1_1
T2T-CHM13v2.01170,604,793 - 170,642,278 (+)NCBIT2T-CHM13v2.0
Fmo1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391162,657,130 - 162,694,170 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1162,657,130 - 162,694,179 (-)EnsemblGRCm39 Ensembl
GRCm381162,829,561 - 162,866,610 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1162,829,561 - 162,866,610 (-)EnsemblGRCm38mm10GRCm38
MGSCv371164,759,692 - 164,796,679 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361164,666,236 - 164,703,223 (-)NCBIMGSCv36mm8
Celera1165,273,712 - 165,303,556 (-)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map170.34NCBI
Fmo1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540611,881,882 - 11,916,323 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540611,882,656 - 11,915,875 (+)NCBIChiLan1.0ChiLan1.0
FMO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2178,472,277 - 78,498,941 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1178,146,459 - 78,173,131 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01146,742,505 - 146,778,560 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11150,456,729 - 150,492,527 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1150,456,729 - 150,492,527 (+)Ensemblpanpan1.1panPan2
FMO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1727,599,230 - 27,623,081 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl727,599,267 - 27,618,237 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha727,120,190 - 27,139,165 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0727,400,502 - 27,424,539 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl727,400,510 - 27,424,542 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1727,251,218 - 27,270,180 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0727,285,744 - 27,304,928 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0727,528,093 - 27,546,971 (-)NCBIUU_Cfam_GSD_1.0
FMO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl963,868,064 - 63,895,076 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1963,860,957 - 63,895,086 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2970,137,610 - 70,171,700 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FMO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12557,781,273 - 57,819,787 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2557,782,085 - 57,819,408 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605559,419,669 - 59,462,141 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fmo1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477110,357,210 - 10,386,005 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477110,358,422 - 10,386,015 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Fmo1
185 total Variants

Predicted Target Of
Summary Value
Count of predictions:74
Count of miRNA genes:60
Interacting mature miRNAs:72
Transcripts:ENSRNOT00000041908
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 36 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)136906051977046890Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat

1 to 10 of 36 rows
RH128136  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21375,182,238 - 75,182,438 (+)MAPPERmRatBN7.2
Rnor_6.01380,712,940 - 80,713,139NCBIRnor6.0
Rnor_5.01385,607,599 - 85,607,798UniSTSRnor5.0
RGSC_v3.41378,503,823 - 78,504,022UniSTSRGSC3.4
Celera1374,919,468 - 74,919,667UniSTS
Cytogenetic Map13q22UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 43 113 91 90 59 25 59 6 212 91 93 45 60 31



Ensembl Acc Id: ENSRNOT00000041908   ⟹   ENSRNOP00000044613
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1375,182,176 - 75,214,647 (-)Ensembl
Rnor_6.0 Ensembl1380,712,882 - 80,745,347 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081551   ⟹   ENSRNOP00000073105
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1375,182,176 - 75,214,647 (-)Ensembl
Rnor_6.0 Ensembl1380,712,885 - 80,738,634 (-)Ensembl
RefSeq Acc Id: NM_012792   ⟹   NP_036924
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81377,715,412 - 77,747,666 (-)NCBI
mRatBN7.21375,182,186 - 75,214,439 (-)NCBI
Rnor_6.01380,712,887 - 80,745,095 (-)NCBI
Rnor_5.01385,607,539 - 85,639,778 (-)NCBI
RGSC_v3.41378,503,770 - 78,536,359 (-)RGD
Celera1374,919,415 - 74,951,610 (-)RGD
Sequence:
RefSeq Acc Id: XM_006250145   ⟹   XP_006250207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81377,715,405 - 77,741,334 (-)NCBI
mRatBN7.21375,182,184 - 75,208,111 (-)NCBI
Rnor_6.01380,713,286 - 80,738,763 (-)NCBI
Rnor_5.01385,607,539 - 85,639,778 (-)NCBI
Sequence:
1 to 10 of 10 rows
Protein RefSeqs NP_036924 (Get FASTA)   NCBI Sequence Viewer  
  XP_006250207 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41165 (Get FASTA)   NCBI Sequence Viewer  
  AAH61567 (Get FASTA)   NCBI Sequence Viewer  
  EDM09392 (Get FASTA)   NCBI Sequence Viewer  
  EDM09393 (Get FASTA)   NCBI Sequence Viewer  
  EDM09394 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000044613
  ENSRNOP00000044613.1
GenBank Protein P36365 (Get FASTA)   NCBI Sequence Viewer  
1 to 10 of 10 rows
RefSeq Acc Id: NP_036924   ⟸   NM_012792
- UniProtKB: A0A8L2R702 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250207   ⟸   XM_006250145
- Peptide Label: isoform X1
- UniProtKB: Q6P7Q5 (UniProtKB/Swiss-Prot),   P36365 (UniProtKB/Swiss-Prot),   A6IDA3 (UniProtKB/TrEMBL),   A0A8L2R702 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000044613   ⟸   ENSRNOT00000041908
Ensembl Acc Id: ENSRNOP00000073105   ⟸   ENSRNOT00000081551

Name Modeler Protein Id AA Range Protein Structure
AF-P36365-F1-model_v2 AlphaFold P36365 1-532 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698943
Promoter ID:EPDNEW_R9468
Type:initiation region
Name:Fmo1_1
Description:flavin containing monooxygenase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01380,745,300 - 80,745,360EPDNEW


1 to 29 of 29 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-17638 BioCyc
Ensembl Genes ENSRNOG00000034191 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000041908 ENTREZGENE
  ENSRNOT00000041908.4 UniProtKB/Swiss-Prot
Gene3D-CATH 3.50.50.60 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6887467 IMAGE-MGC_LOAD
InterPro FAD/NAD-bd_sf UniProtKB/Swiss-Prot
  Flavin_mOase UniProtKB/Swiss-Prot
  Flavin_mOase-like UniProtKB/Swiss-Prot
  Flavin_mOase_1 UniProtKB/Swiss-Prot
  FMO UniProtKB/Swiss-Prot
KEGG Report rno:25256 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72920 IMAGE-MGC_LOAD
NCBI Gene 25256 ENTREZGENE
PANTHER DIMETHYLANILINE MONOOXYGENASE UniProtKB/Swiss-Prot
Pfam FMO-like UniProtKB/Swiss-Prot
PharmGKB FMO1 RGD
PhenoGen Fmo1 PhenoGen
PIRSF FMO UniProtKB/Swiss-Prot
PRINTS FMOXYGENASE UniProtKB/Swiss-Prot
  FMOXYGENASE1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000034191 RatGTEx
Superfamily-SCOP SSF51905 UniProtKB/Swiss-Prot
TIGR TC206326
UniProt A0A8L2R702 ENTREZGENE, UniProtKB/TrEMBL
  A6IDA3 ENTREZGENE, UniProtKB/TrEMBL
  FMO1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6P7Q5 ENTREZGENE
UniProt Secondary Q6P7Q5 UniProtKB/Swiss-Prot
1 to 29 of 29 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-05-09 Fmo1  flavin containing dimethylaniline monoxygenase 1  Fmo1  flavin containing monooxygenase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Fmo1  Flavin-containing monooxygenase 1      Symbol and Name status set to approved 70586 APPROVED