Nqo1 (NAD(P)H quinone dehydrogenase 1) - Rat Genome Database

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Gene: Nqo1 (NAD(P)H quinone dehydrogenase 1) Rattus norvegicus
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Symbol: Nqo1
Name: NAD(P)H quinone dehydrogenase 1
RGD ID: 2503
Description: Enables NAD(P)H dehydrogenase (quinone) activity; NADH:ubiquinone reductase (non-electrogenic) activity; and superoxide dismutase activity. Involved in several processes, including nicotinamide nucleotide metabolic process; regulation of apoptotic process; and response to ischemia. Located in dendrite and neuronal cell body. Used to study several diseases, including chronic kidney disease; colon cancer; hypertension; liver cirrhosis; and membranous glomerulonephritis. Biomarker of several diseases, including cerebrovascular disease (multiple); liver disease (multiple); overactive bladder syndrome; status epilepticus; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including hematologic cancer (multiple); hypertension; lung disease (multiple); macular degeneration; and small cell carcinoma. Orthologous to human NQO1 (NAD(P)H quinone dehydrogenase 1); PARTICIPATES IN nuclear factor, erythroid 2 like 2 signaling pathway; oxidative stress response pathway; doxorubicin pharmacokinetics pathway; INTERACTS WITH (+)-catechin; (-)-selegiline; (3,4-dihydroxyphenyl)acetic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: azoreductase; Dia4; Diaphorase (NADH/NADPH); DT-diaphorase; DTD; menadione reductase; MGC93075; NAD(P)H dehydrogenase [quinone] 1; NAD(P)H dehydrogenase, quinone 1; NAD(P)H:menadione oxidoreductase; NAD(P)H:quinone oxidoreductase 1; phylloquinone reductase; QR1; quinone reductase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   WF.DA-(D19Mit1-D19Mit6)/Kop  
Candidate Gene For: Tcas1 Tcas5 Eau8
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81952,205,374 - 52,220,267 (-)NCBIGRCr8
mRatBN7.21935,295,633 - 35,310,528 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1935,295,573 - 35,310,557 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1942,111,093 - 42,125,986 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01942,764,452 - 42,779,347 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01945,069,378 - 45,085,238 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01938,422,210 - 38,437,103 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1938,422,164 - 38,437,180 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01949,291,903 - 49,306,856 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41937,251,147 - 37,266,040 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11937,255,967 - 37,270,906 (-)NCBI
Celera1934,717,059 - 34,731,947 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Nqo1Ratacute kidney failure treatmentIEP 13440091 RGD 
Nqo1RatAcute Lung Injury treatmentIEP 11035223 RGD 
Nqo1RatAcute Lung Injury treatmentIDA 13442501 RGD 
Nqo1Ratacute lymphoblastic leukemia  ISONQO1 (Homo sapiens)10769359DNA:missense mutations: :p.R139W (465C>T), p.P187S (609C>T) (human)RGD 
Nqo1Ratacute lymphoblastic leukemia  ISONQO1 (Homo sapiens)10769347DNA:mutation: :609C>T (human)RGD 
Nqo1Ratacute myeloid leukemia  ISONQO1 (Homo sapiens)10769358DNA:SNP: :609C>T (human)RGD 
Nqo1Ratalcoholic hepatitis  ISONQO1 (Homo sapiens)405866379protein:altered expression:hepatocyteRGD 
Nqo1RatAlcoholic Liver Diseases amelioratesISONqo1 (Mus musculus)405866379 RGD 
Nqo1Ratasthma susceptibilityISONQO1 (Homo sapiens)5135005DNA:SNP:exon:c.609C>T (human)RGD 
Nqo1Ratasthma  ISONQO1 (Homo sapiens)5135006DNA:SNP:exon:c. 609C>T (human)RGD 
Nqo1RatBrain Injuries  IEP 5134971mRNA:increased expression:lungRGD 
Nqo1RatBrain Injuries treatmentIEP 11035222associated with Subarachnoid HemorrhageRGD 
Nqo1Ratbreast cancer  ISONQO1 (Homo sapiens)10769361 RGD 
Nqo1Ratbreast cancer  IEP 13440090mRNA more ...RGD 
Nqo1RatCarbon Tetrachloride Poisoning treatmentIEP 11035220 RGD 
Nqo1RatCerebral Hemorrhage treatmentIEP 13442476 RGD 
Nqo1RatChemical and Drug Induced Liver Injury treatmentIDA 13439737 RGD 
Nqo1RatChemical and Drug Induced Liver Injury treatmentIEP 15090820 RGD 
Nqo1RatChemical and Drug Induced Liver Injury treatmentISONqo1 (Mus musculus)13439739 RGD 
Nqo1Ratcholestasis treatmentIEP 13439750 RGD 
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Nqo1Ratautosomal dominant dyskeratosis congenita 6  ISONQO1 (Homo sapiens)8554872ClinVar Annotator: match by term: Dyskeratosis congenita and autosomal dominant 6ClinVarPMID:28492532
Nqo1Ratbreast cancer  ISONQO1 (Homo sapiens)8554872ClinVar Annotator: match by term: Breast cancer and post-chemotherapy poor survival inClinVarPMID:10393869 more ...
Nqo1Ratbreast cancer  ISONQO1 (Homo sapiens)8554872ClinVar Annotator: match by term: Breast cancer and post-chemotherapy poor survival inClinVarPMID:10393869 more ...
Nqo1RatChromosome 16q12 Duplication Syndrome  ISONQO1 (Homo sapiens)8554872ClinVar Annotator: match by term: Chromosome 16q12 duplication syndromeClinVarPMID:25741868
Nqo1Ratleukemia  ISONQO1 (Homo sapiens)8554872ClinVar Annotator: match by term: Leukemia more ...ClinVarPMID:10393869 more ...
Nqo1RatPoisoning  ISONQO1 (Homo sapiens)8554872ClinVar Annotator: match by term: Benzene toxicity and susceptibility toClinVarPMID:10393869 more ...
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Nqo1Ratacute kidney failure  ISONQO1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26723870
Nqo1Ratacute lymphoblastic leukemia  ISONQO1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11774269 and PMID:17332311
Nqo1Ratasthma  ISONQO1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20049212
Nqo1Ratautism spectrum disorder  ISONQO1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35663546
Nqo1RatBreast Neoplasms  ISONQO1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18511948
Nqo1Ratcholestasis  ISONQO1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22461449
Nqo1RatColorectal Neoplasms  ISONQO1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20593958
Nqo1Ratcontact dermatitis  ISONQO1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25724174
Nqo1Ratdisease of cellular proliferation  ISONQO1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:8375015
Nqo1RatExperimental Diabetes Mellitus  ISONQO1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:23458895
Nqo1RatExperimental Neoplasms  ISONQO1 (Homo sapiens)11554173CTD more ...CTDPMID:9496914 and PMID:21034357
Nqo1Rathemolytic-uremic syndrome  ISONQO1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12588957
Nqo1RatHemorrhage  ISONQO1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27581200
Nqo1Rathyperglycemia  ISONQO1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:23458895
Nqo1Ratkidney disease  ISONQO1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:21613233
Nqo1Ratliver disease  ISONQO1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16610002 and PMID:17405841
Nqo1Ratlung non-small cell carcinoma  ISONQO1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9865924 and PMID:21479364
Nqo1Ratmetabolic dysfunction-associated steatotic liver disease  ISONQO1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29289645
Nqo1Ratmultiple myeloma  ISONQO1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16949155
Nqo1Ratmyeloid leukemia  ISONQO1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11882782
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Nqo1Rat(+)-albicanol multiple interactionsISONqo1 (Mus musculus)6480464albicanol inhibits the reaction [Galactose results in decreased expression of NQO1 protein]CTDPMID:33761044
Nqo1Rat(+)-catechin decreases expressionEXP 6480464Catechin results in decreased expression of NQO1 proteinCTDPMID:19838946
Nqo1Rat(+)-epicatechin-3-O-gallate multiple interactionsISONQO1 (Homo sapiens)6480464[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] results in increased expression of NQO1 protein and BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] results in increased expression of NQO1 protein]CTDPMID:29061316
Nqo1Rat(+)-pilocarpine increases expressionISONQO1 (Homo sapiens)6480464Pilocarpine results in increased expression of NQO1 proteinCTDPMID:32234387
Nqo1Rat(+)-schisandrin B multiple interactionsISONQO1 (Homo sapiens)6480464[Benzo(a)pyrene co-treated with schizandrin B] results in increased expression of NQO1 mRNA more ...CTDPMID:25946486
Nqo1Rat(+)-taxifolin increases activityISONQO1 (Homo sapiens)6480464taxifolin results in increased activity of NQO1 proteinCTDPMID:17541156
Nqo1Rat(+)-taxifolin increases expressionISONQO1 (Homo sapiens)6480464taxifolin results in increased expression of NQO1 mRNACTDPMID:17541156
Nqo1Rat(+)-trans-(S)-allethrin increases expressionISONQO1 (Homo sapiens)6480464bioallethrin results in increased expression of NQO1 proteinCTDPMID:35511042
Nqo1Rat(+)-trans-(S)-allethrin multiple interactionsISONQO1 (Homo sapiens)6480464[Vitamin E co-treated with bioallethrin] results in increased expression of NQO1 proteinCTDPMID:35511042
Nqo1Rat(+/-)-Aegeline multiple interactionsISONqo1 (Mus musculus)6480464[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of NQO1 mRNACTDPMID:28843594
Nqo1Rat(-)-citrinin increases expressionISONQO1 (Homo sapiens)6480464Citrinin results in increased expression of NQO1 mRNACTDPMID:36460223
Nqo1Rat(-)-demecolcine multiple interactionsISONqo1 (Mus musculus)6480464Demecolcine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]CTDPMID:11602686
Nqo1Rat(-)-epigallocatechin 3-gallate increases expressionISONqo1 (Mus musculus)6480464epigallocatechin gallate results in increased expression of NQO1 mRNACTDPMID:25585349
Nqo1Rat(-)-epigallocatechin 3-gallate multiple interactionsISONQO1 (Homo sapiens)6480464[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] results in increased expression of NQO1 protein more ...CTDPMID:29061316 and PMID:29572906
Nqo1Rat(-)-epigallocatechin 3-gallate multiple interactionsISONqo1 (Mus musculus)6480464[Formaldehyde co-treated with epigallocatechin gallate] results in increased expression of NQO1 protein and epigallocatechin gallate results in increased expression of and results in increased activity of NQO1 proteinCTDPMID:25585349 and PMID:30395894
Nqo1Rat(-)-selegiline increases activityEXP 6480464Selegiline results in increased activity of NQO1 proteinCTDPMID:22019741
Nqo1Rat(-)-selegiline multiple interactionsISONQO1 (Homo sapiens)6480464Selegiline inhibits the reaction [Smoke analog results in increased expression of NQO1 protein]CTDPMID:28108387
Nqo1Rat(-)-selegiline multiple interactionsEXP 6480464NFE2L2 mutant form inhibits the reaction [Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of NQO1 protein]] more ...CTDPMID:22019741
Nqo1Rat(1->4)-beta-D-glucan multiple interactionsISONqo1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of NQO1 mRNACTDPMID:36331819
Nqo1Rat(25R)-cholest-5-ene-3beta,26-diol increases expressionISONQO1 (Homo sapiens)648046427-hydroxycholesterol results in increased expression of NQO1 mRNA and 27-hydroxycholesterol results in increased expression of NQO1 proteinCTDPMID:33880675

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Biological Process
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Nqo1Ratcell redox homeostasis involved_inISONQO1 (Homo sapiens)1624291 PMID:21636573RGDPMID:21636573
Nqo1Ratcell redox homeostasis involved_inIEAUniProtKB:P15559 and ensembl:ENSP000003197881600115GO_REF:0000107EnsemblGO_REF:0000107
Nqo1Ratcellular response to hydrogen peroxide  IDA 13440121 RGD 
Nqo1Ratcellular response to metal ion  IEP 13439714lanthanumRGD 
Nqo1Ratcellular response to oxidative stress involved_inISONQO1 (Homo sapiens)1624291 PMID:15687255RGDPMID:15687255
Nqo1Ratcellular response to oxidative stress involved_inIEAUniProtKB:P15559 and ensembl:ENSP000003197881600115GO_REF:0000107EnsemblGO_REF:0000107
Nqo1Ratinnate immune response involved_inISONqo1 (Mus musculus)1624291MGI:2388490 PMID:29934320RGDPMID:29934320
Nqo1Ratinnate immune response involved_inIEAUniProtKB:Q64669 and ensembl:ENSMUSP000000039471600115GO_REF:0000107EnsemblGO_REF:0000107
Nqo1Ratnegative regulation of apoptotic process  IDA 10769366 RGD 
Nqo1Ratnegative regulation of catalytic activity acts_upstream_of_or_withinISONqo1 (Mus musculus)1624291 PMID:10903442RGDPMID:10903442
Nqo1Ratnegative regulation of ferroptosis involved_inISONQO1 (Homo sapiens)1624291 PMID:26403645RGDPMID:26403645
Nqo1Ratnegative regulation of ferroptosis involved_inIEAUniProtKB:P15559 and ensembl:ENSP000003197881600115GO_REF:0000107EnsemblGO_REF:0000107
Nqo1Ratnegative regulation of ferroptosis involved_inISSUniProtKB:P155591600115GO_REF:0000024UniProtGO_REF:0000024
Nqo1Ratnegative regulation of protein catabolic process involved_inISSUniProtKB:P155591600115GO_REF:0000024UniProtGO_REF:0000024
Nqo1Ratnegative regulation of protein catabolic process involved_inIEAUniProtKB:P15559 and ensembl:ENSP000003197881600115GO_REF:0000107EnsemblGO_REF:0000107
Nqo1Ratnegative regulation of protein catabolic process involved_inISONQO1 (Homo sapiens)1624291 PMID:15687255RGDPMID:15687255
Nqo1Ratobsolete NADPH oxidation  IDA 25823192 RGD 
Nqo1Ratpositive regulation of NAD metabolic process  IDA 25823193 RGD 
Nqo1Ratpositive regulation of neuron apoptotic process  IMP 727509 RGD 
Nqo1Ratprotein catabolic process involved_inISONqo1 (Mus musculus)1624291 PMID:29934320RGDPMID:29934320
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Cellular Component
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Nqo1Ratcytoplasm is_active_inIEAUniProtKB:Q64669 and ensembl:ENSMUSP000000039471600115GO_REF:0000107EnsemblGO_REF:0000107
Nqo1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Nqo1Ratcytoplasm is_active_inISONqo1 (Mus musculus)1624291 PMID:29934320RGDPMID:29934320
Nqo1Ratcytosol located_inIEAUniProtKB-SubCell:SL-00911600115GO_REF:0000044UniProtGO_REF:0000044
Nqo1Ratcytosol located_inIEAUniProtKB:P15559 and ensembl:ENSP000003197881600115GO_REF:0000107EnsemblGO_REF:0000107
Nqo1Ratcytosol is_active_inIBAPANTHER:PTN000024521 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Nqo1Ratcytosol located_inISONQO1 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Nqo1Ratcytosol located_inISONQO1 (Homo sapiens)1624291 PMID:10945627RGDPMID:10945627
Nqo1Ratdendrite  IDA 13439751 RGD 
Nqo1Ratneuronal cell body  IDA 5133254 RGD 
Nqo1Ratnucleus is_active_inISONqo1 (Mus musculus)1624291 PMID:29934320RGDPMID:29934320
Nqo1Ratnucleus is_active_inIEAUniProtKB:Q64669 and ensembl:ENSMUSP000000039471600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function
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Nqo1Ratidentical protein binding enablesISONQO1 (Homo sapiens)1624291UniProtKB:P15559 and PMID:25143260RGDPMID:25143260
Nqo1Ratidentical protein binding enablesIEAUniProtKB:P15559 and ensembl:ENSP000003197881600115GO_REF:0000107EnsemblGO_REF:0000107
Nqo1RatNAD(P)H dehydrogenase (quinone) activity  IDA 727509 RGD 
Nqo1RatNAD(P)H dehydrogenase (quinone) activity enablesISONqo1 (Mus musculus)1624291 PMID:15386390 more ...RGDPMID:15386390 more ...
Nqo1RatNAD(P)H dehydrogenase (quinone) activity enablesIEAUniProtKB:Q64669 and ensembl:ENSMUSP000000039471600115GO_REF:0000107EnsemblGO_REF:0000107
Nqo1RatNAD(P)H dehydrogenase (quinone) activity enablesIEAEC:1.6.5.21600115GO_REF:0000003UniProtGO_REF:0000003
Nqo1RatNAD(P)H dehydrogenase (quinone) activity enablesIBAMGI:103187 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Nqo1RatNADH:ubiquinone reductase (non-electrogenic) activity enablesIDA 151356617PMID:8999809UniProt 
Nqo1RatNADH:ubiquinone reductase (non-electrogenic) activity enablesIEAUniProtKB:Q64669 and ensembl:ENSMUSP000000039471600115GO_REF:0000107EnsemblGO_REF:0000107
Nqo1RatNADH:ubiquinone reductase (non-electrogenic) activity enablesISONqo1 (Mus musculus)1624291 PMID:8999809RGDPMID:8999809
Nqo1RatNADH:ubiquinone reductase (non-electrogenic) activity enablesIEAUniProtKB:P15559 and ensembl:ENSP000003197881600115GO_REF:0000107EnsemblGO_REF:0000107
Nqo1RatNADH:ubiquinone reductase (non-electrogenic) activity enablesIEARHEA:461601600115GO_REF:0000116RHEAGO_REF:0000116
Nqo1RatNADH:ubiquinone reductase (non-electrogenic) activity enablesISONQO1 (Homo sapiens)1624291 PMID:8999809 and PMID:9271353RGDPMID:8999809 and PMID:9271353
Nqo1RatNADPH dehydrogenase (quinone) activity enablesIEARHEA:461641600115GO_REF:0000116RHEAGO_REF:0000116
Nqo1Ratoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
Nqo1Ratprotein binding enablesISONQO1 (Homo sapiens)1624291UniProtKB:P04637 more ...RGDPMID:15687255 more ...
Nqo1Ratprotein binding enablesISONqo1 (Mus musculus)1624291UniProtKB:Q8R1G6 more ...RGDPMID:29934320
Nqo1Ratsuperoxide dismutase activity  IMP 5133248 RGD 
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RGD Manual Annotations


  
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Original Reference(s)
Nqo1Ratdoxorubicin pharmacokinetics pathway   ISONQO1 (Homo sapiens)10395262 RGD 
Nqo1Ratnuclear factor, erythroid 2 like 2 signaling pathway   IEP 25823187 RGD 
Nqo1Ratnuclear factor, erythroid 2 like 2 signaling pathway   IEP 21201308 RGD 
Nqo1Ratoxidative stress response pathway  IDA 727509 RGD 
Nqo1Ratoxidative stress response pathway  IDA 15090820blood protein analysis (MMO:0000166), western blot assay (MMO:0000669)RGD 

Imported Annotations - SMPDB

Object Symbol
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Original Reference(s)
Nqo1Ratdoxorubicin pharmacokinetics pathway   ISONQO1 (Homo sapiens)10402751 SMPDBSMP:00650
Nqo1Ratphenytoin pharmacodynamics pathway  ISONQO1 (Homo sapiens)10402751 SMPDBSMP:00327
Nqo1Ratvitamin K metabolic pathway  ISONQO1 (Homo sapiens)10402751 SMPDBSMP:00464

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Reference Title
Reference Citation
1. Insights into the potential antidepressant mechanisms of cilostazol in chronically restraint rats: impact on the Nrf2 pathway. Abuelezz SA and Hendawy N, Behav Pharmacol. 2017 Jul 31. doi: 10.1097/FBP.0000000000000335.
2. Metformin attenuates streptozotocin-induced diabetic nephropathy in rats through modulation of oxidative stress genes expression. Alhaider AA, etal., Chem Biol Interact. 2011 Jul 15;192(3):233-42. doi: 10.1016/j.cbi.2011.03.014. Epub 2011 Mar 30.
3. Inhibition of colon carcinogenesis by post-initiation induction of NQO1 in Sprague-Dawley rats. Begleiter A, etal., Oncol Rep. 2009 Jun;21(6):1559-65.
4. Antifibrogenic effect of melatonin in rats with experimental liver cirrhosis induced by carbon tetrachloride. Bona S, etal., JGH Open. 2018 May 24;2(4):117-123. doi: 10.1002/jgh3.12055. eCollection 2018 Aug.
5. Role of the Nrf2-ARE pathway in early brain injury after experimental subarachnoid hemorrhage. Chen G, etal., J Neurosci Res. 2011 Apr;89(4):515-23. doi: 10.1002/jnr.22577. Epub 2011 Jan 21.
6. Molecular basis of the catalytic differences among DT-diaphorase of human, rat, and mouse. Chen S, etal., J Biol Chem. 1997 Jan 17;272(3):1437-9. doi: 10.1074/jbc.272.3.1437.
7. Adipose-derived mesenchymal stem cell protects kidneys against ischemia-reperfusion injury through suppressing oxidative stress and inflammatory reaction. Chen YT, etal., J Transl Med. 2011 May 5;9:51. doi: 10.1186/1479-5876-9-51.
8. Testosterone Propionate Exacerbates the Deficits of Nigrostriatal Dopaminergic System and Downregulates Nrf2 Expression in Reserpine-Treated Aged Male Rats. Cui R, etal., Front Aging Neurosci. 2017 May 31;9:172. doi: 10.3389/fnagi.2017.00172. eCollection 2017.
9. BALT development and augmentation of hyperoxic lung injury in mice deficient in NQO1 and NQO2. Das A, etal., Free Radic Biol Med. 2006 May 15;40(10):1843-56. Epub 2006 Feb 17.
10. Activation of AhR-NQO1 Signaling Pathway Protects Against Alcohol-Induced Liver Injury by Improving Redox Balance. Dong H, etal., Cell Mol Gastroenterol Hepatol. 2021;12(3):793-811. doi: 10.1016/j.jcmgh.2021.05.013. Epub 2021 May 31.
11. Influence of NQO1, ALDH2, and CYP2E1 genetic polymorphisms, smoking, and alcohol drinking on the risk of lung cancer in Koreans. Eom SY, etal., Cancer Causes Control. 2009 Mar;20(2):137-45. Epub 2008 Sep 17.
12. Overabundant FANCD2, alone and combined with NQO1, is a sensitive marker of adverse prognosis in breast cancer. Fagerholm R, etal., Ann Oncol. 2013 Nov;24(11):2780-5. doi: 10.1093/annonc/mdt290. Epub 2013 Jul 29.
13. Differential responses of targeted lung redox enzymes to rat exposure to 60 or 85% oxygen. Gan Z, etal., J Appl Physiol (1985). 2011 Jul;111(1):95-107. doi: 10.1152/japplphysiol.01451.2010. Epub 2011 May 5.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. Functional polymorphism of detoxification gene NQO1 predicts intensity of empirical treatment of childhood asthma. Goodrich GG, etal., Mutat Res. 2009 Mar 31;674(1-2):55-61. Epub 2008 Nov 5.
17. Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema. Goven D, etal., Thorax. 2008 Oct;63(10):916-24. Epub 2008 Jun 17.
18. Danhong injection attenuates ischemia/reperfusion-induced brain damage which is associating with Nrf2 levels in vivo and in vitro. Guo H, etal., Neurochem Res. 2014 Sep;39(9):1817-24. doi: 10.1007/s11064-014-1384-1. Epub 2014 Jul 29.
19. Yinchen Linggui Zhugan Decoction Ameliorates Nonalcoholic Fatty Liver Disease in Rats by Regulating the Nrf2/ARE Signaling Pathway. Guo Y, etal., Evid Based Complement Alternat Med. 2017;2017:6178358. doi: 10.1155/2017/6178358. Epub 2017 Aug 28.
20. Fine structure and synaptology of the nitrergic neurons in medial septum of the rat brain. Halasy K, etal., Acta Biol Hung. 2017 Mar;68(1):1-13. doi: 10.1556/018.68.2017.1.1.
1 to 20 of 115 rows
PMID:1703398   PMID:1914521   PMID:2141979   PMID:2480957   PMID:2499768   PMID:2504488   PMID:2963593   PMID:3100515   PMID:3143406   PMID:3144286   PMID:3536915   PMID:7568029  
PMID:10903442   PMID:10945627   PMID:11740593   PMID:12477932   PMID:12634484   PMID:12663061   PMID:12699333   PMID:14564531   PMID:14980808   PMID:15288499   PMID:15386390   PMID:15489334  
PMID:15652701   PMID:16190898   PMID:16392039   PMID:16426587   PMID:17372386   PMID:17626271   PMID:18563540   PMID:18626777   PMID:19180910   PMID:19229058   PMID:19815007   PMID:19821077  
PMID:20593958   PMID:20594978   PMID:20732396   PMID:21636573   PMID:21781119   PMID:22028090   PMID:22031657   PMID:22073370   PMID:22154326   PMID:22658674   PMID:23376485   PMID:23420945  
PMID:23749777   PMID:24300172   PMID:24506563   PMID:24707733   PMID:24769487   PMID:24951727   PMID:25143260   PMID:25164943   PMID:27242267   PMID:28478529   PMID:29706024   PMID:29889218  
PMID:30062552   PMID:31227177   PMID:31915512   PMID:32685505   PMID:34817874   PMID:37002649   PMID:37285672  



Nqo1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81952,205,374 - 52,220,267 (-)NCBIGRCr8
mRatBN7.21935,295,633 - 35,310,528 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1935,295,573 - 35,310,557 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1942,111,093 - 42,125,986 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01942,764,452 - 42,779,347 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01945,069,378 - 45,085,238 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01938,422,210 - 38,437,103 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1938,422,164 - 38,437,180 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01949,291,903 - 49,306,856 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41937,251,147 - 37,266,040 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11937,255,967 - 37,270,906 (-)NCBI
Celera1934,717,059 - 34,731,947 (-)NCBICelera
Cytogenetic Map19q12NCBI
NQO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381669,709,401 - 69,726,560 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1669,706,996 - 69,726,668 (-)EnsemblGRCh38hg38GRCh38
GRCh371669,743,304 - 69,760,463 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361668,300,805 - 68,318,034 (-)NCBINCBI36Build 36hg18NCBI36
Build 341668,300,809 - 68,317,893NCBI
Celera1654,257,766 - 54,274,991 (-)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1655,621,397 - 55,638,606 (-)NCBIHuRef
CHM1_11671,151,192 - 71,168,417 (-)NCBICHM1_1
T2T-CHM13v2.01675,511,583 - 75,528,719 (-)NCBIT2T-CHM13v2.0
Nqo1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398108,114,856 - 108,139,012 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8108,114,857 - 108,129,838 (-)EnsemblGRCm39 Ensembl
GRCm388107,388,225 - 107,403,205 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8107,388,225 - 107,403,206 (-)EnsemblGRCm38mm10GRCm38
MGSCv378109,912,125 - 109,927,105 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368110,277,349 - 110,292,395 (-)NCBIMGSCv36mm8
Celera8111,617,929 - 111,633,856 (-)NCBICelera
Cytogenetic Map8D3NCBI
cM Map854.08NCBI
Nqo1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554847,012,506 - 7,027,604 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554847,012,373 - 7,028,182 (+)NCBIChiLan1.0ChiLan1.0
NQO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21879,260,777 - 79,276,881 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11685,172,915 - 85,188,752 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01650,090,696 - 50,106,495 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11669,472,529 - 69,489,731 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1669,470,288 - 69,489,731 (-)Ensemblpanpan1.1panPan2
NQO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1579,979,593 - 79,990,875 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl579,978,865 - 79,989,860 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha579,968,342 - 79,979,690 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0580,409,927 - 80,421,414 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl580,409,969 - 80,420,809 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1580,237,718 - 80,249,198 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0579,927,217 - 79,938,546 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0580,560,166 - 80,571,660 (+)NCBIUU_Cfam_GSD_1.0
Nqo1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934939,803,797 - 39,817,919 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647519,769,488 - 19,785,311 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647519,771,384 - 19,785,034 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NQO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl617,292,770 - 17,302,590 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1617,292,962 - 17,302,593 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2616,238,853 - 16,248,813 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NQO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1557,676,547 - 57,695,434 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl557,675,981 - 57,716,599 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604720,406,748 - 20,425,872 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nqo1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474616,684,407 - 16,697,479 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474616,684,620 - 16,698,194 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Nqo1
85 total Variants


Assembly: Rnor_5.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
19 49301608 49301609 G A snv DOB/Oda (KyushuU) View more Information

Predicted Target Of
Summary Value
Count of predictions:384
Count of miRNA genes:216
Interacting mature miRNAs:254
Transcripts:ENSRNOT00000017174
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 25 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192481797839654489Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat

1 to 10 of 25 rows
RH128318  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21935,295,622 - 35,295,816 (-)MAPPERmRatBN7.2
Rnor_6.01938,436,920 - 38,437,113NCBIRnor6.0
Rnor_5.01949,306,613 - 49,306,806UniSTSRnor5.0
RGSC_v3.41937,251,137 - 37,251,330UniSTSRGSC3.4
Celera1934,717,049 - 34,717,242UniSTS
RH 3.4 Map19314.8UniSTS
Cytogenetic Map19q12UniSTS


The following Strains have been annotated to Nqo1
WF.DA-(D19Mit1-D19Mit6)/Kop    




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000017174   ⟹   ENSRNOP00000017175
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1935,295,640 - 35,310,549 (-)Ensembl
Rnor_6.0 Ensembl1938,422,164 - 38,437,180 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112166   ⟹   ENSRNOP00000082814
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1935,295,573 - 35,310,557 (-)Ensembl
RefSeq Acc Id: NM_017000   ⟹   NP_058696
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81952,205,374 - 52,220,267 (-)NCBI
mRatBN7.21935,295,633 - 35,310,528 (-)NCBI
Rnor_6.01938,422,210 - 38,437,103 (+)NCBI
Rnor_5.01949,291,903 - 49,306,856 (+)NCBI
RGSC_v3.41937,251,147 - 37,266,040 (-)RGD
Celera1934,717,059 - 34,731,947 (-)RGD
Sequence:
1 to 11 of 11 rows
Protein RefSeqs NP_058696 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41715 (Get FASTA)   NCBI Sequence Viewer  
  AAA41716 (Get FASTA)   NCBI Sequence Viewer  
  AAA41988 (Get FASTA)   NCBI Sequence Viewer  
  AAA41989 (Get FASTA)   NCBI Sequence Viewer  
  AAA41990 (Get FASTA)   NCBI Sequence Viewer  
  AAH83542 (Get FASTA)   NCBI Sequence Viewer  
  EDL92478 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017175
  ENSRNOP00000082814.1
GenBank Protein P05982 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_058696   ⟸   NM_017000
- UniProtKB: Q63478 (UniProtKB/Swiss-Prot),   P05982 (UniProtKB/Swiss-Prot),   A6IZ00 (UniProtKB/TrEMBL),   A0A8L2UJ69 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017175   ⟸   ENSRNOT00000017174
Ensembl Acc Id: ENSRNOP00000082814   ⟸   ENSRNOT00000112166
Flavodoxin-like fold

Name Modeler Protein Id AA Range Protein Structure
AF-P05982-F1-model_v2 AlphaFold P05982 1-274 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13701110
Promoter ID:EPDNEW_R11634
Type:single initiation site
Name:Nqo1_1
Description:NADH quinone dehydrogenase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01938,422,181 - 38,422,241EPDNEW


1 to 26 of 26 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-5759 BioCyc
BioCyc Pathway PWY-7999 [vitamin K-epoxide cycle] BioCyc
BioCyc Pathway Image PWY-7999 BioCyc
Ensembl Genes ENSRNOG00000012772 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000017174 ENTREZGENE
  ENSRNOT00000112166.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.360 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7190779 IMAGE-MGC_LOAD
InterPro Flavodoxin_fold UniProtKB/Swiss-Prot
  Flavoprotein-like_sf UniProtKB/Swiss-Prot
  NAD(P)H_dehydrogenase_qn UniProtKB/Swiss-Prot
KEGG Report rno:24314 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93075 IMAGE-MGC_LOAD
NCBI Gene 24314 ENTREZGENE
PANTHER NAD P H OXIDOREDUCTASE-RELATED UniProtKB/Swiss-Prot
  NAD(P)H DEHYDROGENASE [QUINONE] 1 UniProtKB/Swiss-Prot
Pfam Flavodoxin_2 UniProtKB/Swiss-Prot
PharmGKB NQO1 RGD
PhenoGen Nqo1 PhenoGen
RatGTEx ENSRNOG00000012772 RatGTEx
Superfamily-SCOP SSF52218 UniProtKB/Swiss-Prot
UniProt A0A8L2UJ69 ENTREZGENE, UniProtKB/TrEMBL
  A6IZ00 ENTREZGENE, UniProtKB/TrEMBL
  NQO1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63478 ENTREZGENE
UniProt Secondary Q63478 UniProtKB/Swiss-Prot
1 to 26 of 26 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-29 Nqo1  NAD(P)H quinone dehydrogenase 1  Nqo1  NAD(P)H dehydrogenase, quinone 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Nqo1  NAD(P)H dehydrogenase, quinone 1  Dia4  Diaphorase (NADH/NADPH)  Symbol and Name updated 625702 APPROVED
2002-06-10 Dia4  Diaphorase (NADH/NADPH)      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_process induction of activity results in increased neuronal damage following cerebral ischaemia 727509