Cma1 (chymase 1) - Rat Genome Database

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Gene: Cma1 (chymase 1) Rattus norvegicus
Analyze
Symbol: Cma1
Name: chymase 1
RGD ID: 2365
Description: Enables peptide binding activity and serine-type endopeptidase activity. Involved in several processes, including cellular response to glucose stimulus; midbrain development; and positive regulation of angiogenesis. Located in extracellular region. Biomarker of renovascular hypertension. Human ortholog(s) of this gene implicated in asthma; atopic dermatitis; hypertrophic cardiomyopathy; and sarcoidosis. Orthologous to human CMA1 (chymase 1); PARTICIPATES IN angiotensin II signaling pathway; renin-angiotensin cascade pathway; INTERACTS WITH adefovir; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: alpha-chymase; chymase; chymase 1 mast cell; chymase 1, mast cell; mast cell protease 3; mast cell protease 5; mast cell protease III; MCP3P; Mcpt5; rMCP-3; rMCP-5; rMCP-III
RGD Orthologs
Human
Mouse
Bonobo
Dog
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,387,351 - 33,390,133 (-)NCBIGRCr8
mRatBN7.21529,417,451 - 29,420,233 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,417,451 - 29,420,233 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1531,263,077 - 31,265,859 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,410,295 - 32,413,077 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,652,671 - 30,655,453 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01534,601,037 - 34,603,819 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,601,037 - 34,603,819 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01538,490,971 - 38,493,753 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41534,083,202 - 34,084,387 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11534,098,901 - 34,102,176 (-)NCBI
Celera1528,991,244 - 28,994,014 (-)NCBICelera
RH 3.4 Map15213.78RGD
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A protease activated receptor-2 (PAR-2) activating peptide, tc-LIGRLO-NH2, induces protease release from mast cells: role in TNF degradation. Alshurafa HN, etal., BMC Pharmacol. 2004 Jul 20;4:12.
2. Mast cell phenotype, location, and activation in severe asthma: data from the severe asthma research program. Balzar S, etal., Am J Respir Crit Care Med. 2011 Feb 1;183(3):299-309. Epub 2010 Sep 2.
3. Assessment of bronchial inflammation using an automated cell recognition system based on colour analysis. Berger P, etal., Eur Respir J. 1999 Dec;14(6):1394-402.
4. Segmental bronchoprovocation in allergic rhinitis patients affects mast cell and basophil numbers in nasal and bronchial mucosa. Braunstahl GJ, etal., Am J Respir Crit Care Med. 2001 Sep 1;164(5):858-65.
5. The Impact of Maternal Separation on the Number of Tyrosine Hydroxylase-Expressing Midbrain Neurons during Different Stages of Ontogenesis. Chocyk A, etal., Neuroscience. 2011 Mar 8.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Association of mast cells with lung function in chronic obstructive pulmonary disease. Gosman MM, etal., Respir Res. 2008 Sep 10;9:64.
8. Increased expression of mast cell chymase in the lungs of patients with congenital heart disease associated with early pulmonary vascular disease. Hamada H, etal., Am J Respir Crit Care Med. 1999 Oct;160(4):1303-8.
9. Evidence for a role of mast cells in the evolution to congestive heart failure. Hara M, etal., J Exp Med. 2002 Feb 4;195(3):375-81.
10. Enhanced mast cell chymase expression in human idiopathic interstitial pneumonia. Hirata K, etal., Int J Mol Med. 2007 Apr;19(4):565-70.
11. Cloning of the cDNA encoding a novel rat mast-cell proteinase, rMCP-3, and its expression in comparison with other rat mast-cell proteinases. Ide H, etal., Biochem J 1995 Oct 15;311 ( Pt 2):675-80.
12. Polymorphism of the mast cell chymase gene (CMA1) promoter region: lack of association with asthma but association with serum total immunoglobulin E levels in adult atopic dermatitis. Iwanaga T, etal., Clin Exp Allergy. 2004 Jul;34(7):1037-42.
13. Tranilast reduces mesenteric vascular collagen deposition and chymase-positive mast cells in experimental diabetes. Jones SE, etal., J Diabetes Complications. 2004 Sep-Oct;18(5):309-15.
14. Extended substrate specificity of rat mast cell protease 5, a rodent alpha-chymase with elastase-like primary specificity. Karlson U, etal., J Biol Chem. 2003 Oct 10;278(41):39625-31. Epub 2003 Aug 4.
15. Gene expression of cardiac mast cell chymase and tryptase in a murine model of heart failure caused by viral myocarditis. Kitaura-Inenaga K, etal., Circ J. 2003 Oct;67(10):881-4.
16. Human chymase expression in a mice induces mild hypertension with left ventricular hypertrophy. Koga T, etal., Hypertens Res. 2003 Sep;26(9):759-68.
17. Chymase gene (CMA1) polymorphisms in Dutch and Japanese sarcoidosis patients. Kruit A, etal., Respiration. 2006;73(5):623-33. Epub 2006 Jan 27.
18. Rodent alpha-chymases are elastase-like proteases. Kunori Y, etal., Eur J Biochem. 2002 Dec;269(23):5921-30.
19. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
20. Targeting the renin-angiotensin system: what's new? Leckie BJ Curr Med Chem Cardiovasc Hematol Agents. 2005 Jan;3(1):23-32.
21. Mast cell chymase induces smooth muscle cell apoptosis by a mechanism involving fibronectin degradation and disruption of focal adhesions. Leskinen MJ, etal., Arterioscler Thromb Vasc Biol 2003 Feb 1;23(2):238-43.
22. Secretory granule proteases in rat mast cells. Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations. Lutzelschwab C, etal., J Exp Med 1997 Jan 6;185(1):13-29.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Differential accumulation of pulmonary and cardiac mast cell-subsets and eosinophils between fatal anaphylaxis and asthma death: a postmortem comparative study. Perskvist N and Edston E, Forensic Sci Int. 2007 Jun 14;169(1):43-9. Epub 2006 Nov 1.
26. Angiotensin-converting enzyme and heart chymase gene polymorphisms in hypertrophic cardiomyopathy. Pfeufer A, etal., Am J Cardiol. 1996 Aug 1;78(3):362-4.
27. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
28. GOA pipeline RGD automated data pipeline
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Inhibition of granuloma-associated angiogenesis by controlling mast cell mediator release: role of mast cell protease-5. Russo A, etal., Br J Pharmacol. 2005 May;145(1):24-33.
31. Angiotensin converting enzyme-independent angiotensin ii production by chymase is up-regulated in the ischemic kidney in renovascular hypertension. Sadjadi J, etal., J Surg Res. 2005 Aug;127(2):65-9.
32. A novel (TG)n(GA)m repeat polymorphism 254 bp downstream of the mast cell chymase (CMA1) gene is associated with atopic asthma and total serum IgE levels. Sharma S, etal., J Hum Genet. 2005;50(6):276-82. Epub 2005 May 28.
33. High-glucose-induced regulation of intracellular ANG II synthesis and nuclear redistribution in cardiac myocytes. Singh VP, etal., Am J Physiol Heart Circ Physiol. 2007 Aug;293(2):H939-48. Epub 2007 May 4.
34. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
35. Association study of mast cell chymase polymorphisms with atopy. Weidinger S, etal., Allergy. 2005 Oct;60(10):1256-61.
Additional References at PubMed
PMID:1919436   PMID:2266130   PMID:9256427   PMID:9360993   PMID:11502696   PMID:12062105   PMID:16460729   PMID:16690960   PMID:18057996   PMID:18079408   PMID:20551380   PMID:22875344  
PMID:26807691   PMID:27068509   PMID:27465904   PMID:27559042   PMID:28748720   PMID:29529050   PMID:31036322  


Genomics

Comparative Map Data
Cma1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,387,351 - 33,390,133 (-)NCBIGRCr8
mRatBN7.21529,417,451 - 29,420,233 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,417,451 - 29,420,233 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1531,263,077 - 31,265,859 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,410,295 - 32,413,077 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,652,671 - 30,655,453 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01534,601,037 - 34,603,819 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,601,037 - 34,603,819 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01538,490,971 - 38,493,753 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41534,083,202 - 34,084,387 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11534,098,901 - 34,102,176 (-)NCBI
Celera1528,991,244 - 28,994,014 (-)NCBICelera
RH 3.4 Map15213.78RGD
Cytogenetic Map15p12NCBI
CMA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381424,505,353 - 24,508,265 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1424,505,353 - 24,508,265 (-)EnsemblGRCh38hg38GRCh38
GRCh371424,974,559 - 24,977,471 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361424,044,552 - 24,047,311 (-)NCBINCBI36Build 36hg18NCBI36
Build 341424,044,551 - 24,047,311NCBI
Celera144,839,478 - 4,842,237 (-)NCBICelera
Cytogenetic Map14q12NCBI
HuRef145,089,481 - 5,092,240 (-)NCBIHuRef
CHM1_11424,973,574 - 24,976,333 (-)NCBICHM1_1
T2T-CHM13v2.01418,704,211 - 18,707,123 (-)NCBIT2T-CHM13v2.0
Cma1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391456,178,908 - 56,182,132 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1456,178,908 - 56,182,132 (-)EnsemblGRCm39 Ensembl
GRCm381455,941,451 - 55,944,675 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,941,451 - 55,944,675 (-)EnsemblGRCm38mm10GRCm38
MGSCv371456,560,288 - 56,563,498 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361454,895,522 - 54,898,732 (-)NCBIMGSCv36mm8
Celera1453,745,166 - 53,748,376 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
CMA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21525,855,859 - 25,858,985 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11425,072,378 - 25,075,477 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0145,277,269 - 5,280,335 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11423,400,677 - 23,402,819 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1423,400,345 - 23,403,548 (-)Ensemblpanpan1.1panPan2
CMA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,438,244 - 4,441,189 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,438,244 - 4,441,189 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha84,359,948 - 4,362,893 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.084,549,708 - 4,552,661 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl84,549,715 - 4,552,661 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.184,239,198 - 4,242,142 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.084,301,888 - 4,304,834 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.084,564,103 - 4,567,048 (-)NCBIUU_Cfam_GSD_1.0
CMA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1241,471,767 - 1,475,062 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl241,471,725 - 1,474,692 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603613,158,008 - 13,161,323 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cma1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248208,021,959 - 8,024,851 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248208,021,965 - 8,024,763 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cma1
7 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:29
Count of miRNA genes:29
Interacting mature miRNAs:29
Transcripts:ENSRNOT00000067539
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat

Markers in Region
RH131228  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21529,417,556 - 29,417,745 (+)MAPPERmRatBN7.2
Rnor_6.01534,601,143 - 34,601,331NCBIRnor6.0
Rnor_5.01538,491,077 - 38,491,265UniSTSRnor5.0
RGSC_v3.41534,083,308 - 34,083,496UniSTSRGSC3.4
Celera1528,991,350 - 28,991,538UniSTS
RH 3.4 Map15260.81UniSTS
Cytogenetic Map15p13UniSTS
RH94861  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21529,417,451 - 29,417,609 (+)MAPPERmRatBN7.2
Rnor_6.01534,601,038 - 34,601,195NCBIRnor6.0
Rnor_5.01538,490,972 - 38,491,129UniSTSRnor5.0
RGSC_v3.41534,083,203 - 34,083,360UniSTSRGSC3.4
Celera1528,991,245 - 28,991,402UniSTS
RH 3.4 Map15213.78UniSTS
Cytogenetic Map15p13UniSTS
Cma1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21529,417,760 - 29,418,259 (+)MAPPERmRatBN7.2
Rnor_6.01534,601,347 - 34,601,845NCBIRnor6.0
Rnor_5.01538,491,281 - 38,491,779UniSTSRnor5.0
Celera1528,991,554 - 28,992,052UniSTS
Cytogenetic Map15p13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 1 2 2 2 6 1 2
Low 3 28 42 27 18 27 6 9 18 26 21 10 6
Below cutoff 3 10 10 10 16 9 12

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000067539   ⟹   ENSRNOP00000061330
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1529,417,451 - 29,420,233 (-)Ensembl
Rnor_6.0 Ensembl1534,601,037 - 34,603,819 (-)Ensembl
RefSeq Acc Id: NM_013092   ⟹   NP_037224
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,387,351 - 33,390,133 (-)NCBI
mRatBN7.21529,417,451 - 29,420,233 (-)NCBI
Rnor_6.01534,601,037 - 34,603,819 (-)NCBI
Rnor_5.01538,490,971 - 38,493,753 (-)NCBI
RGSC_v3.41534,083,202 - 34,084,387 (-)RGD
Celera1528,991,244 - 28,994,014 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_037224 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB48261 (Get FASTA)   NCBI Sequence Viewer  
  BAA07507 (Get FASTA)   NCBI Sequence Viewer  
  EDM14296 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000061330
  ENSRNOP00000061330.2
  ENSRNOP00055016489
  ENSRNOP00060033998
  ENSRNOP00065043492
GenBank Protein P50339 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_037224   ⟸   NM_013092
- Peptide Label: precursor
- UniProtKB: Q9R2C8 (UniProtKB/Swiss-Prot),   P50339 (UniProtKB/Swiss-Prot),   A6KH67 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000061330   ⟸   ENSRNOT00000067539
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P50339-F1-model_v2 AlphaFold P50339 1-247 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699698
Promoter ID:EPDNEW_R10221
Type:initiation region
Name:Cma1_1
Description:chymase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01534,603,814 - 34,603,874EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2365 AgrOrtholog
BioCyc Gene G2FUF-13674 BioCyc
Ensembl Genes ENSRNOG00000020563 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055012055 UniProtKB/Swiss-Prot
  ENSRNOG00060023735 UniProtKB/Swiss-Prot
  ENSRNOG00065030740 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000067539 ENTREZGENE
  ENSRNOT00000067539.3 UniProtKB/Swiss-Prot
  ENSRNOT00055020486 UniProtKB/Swiss-Prot
  ENSRNOT00060041069 UniProtKB/Swiss-Prot
  ENSRNOT00065052964 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25627 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25627 ENTREZGENE
PANTHER CHYMASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KALLIKREIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CMA1 RGD
PhenoGen Cma1 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020563 RatGTEx
  ENSRNOG00055012055 RatGTEx
  ENSRNOG00060023735 RatGTEx
  ENSRNOG00065030740 RatGTEx
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC207298
UniProt A6KH67 ENTREZGENE, UniProtKB/TrEMBL
  CMA1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9R2C8 ENTREZGENE
UniProt Secondary Q9R2C8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-01 Cma1  chymase 1  Cma1  chymase 1, mast cell  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Cma1  chymase 1, mast cell    chymase 1  Name updated 1299863 APPROVED
2002-06-10 Cma1  chymase 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in peritoneal mast cells, skin, tongue and RBL2H3 basophilic leukemia cells; weakly expressed in jejunum of N. brasiliensis-infected rats 1298761
gene_expression expressed in connective tissue mast cells of ear and peritoneum 69811
gene_function has proteolytic activity 1298762
gene_process may facilitate apoptosis by playing a role in fibronectin degradation and disruption of the p-FAK cell survival cascade 1298762
gene_protein mature enzyme is 226 amino acids 1298761