Usp43 (ubiquitin specific peptidase 43) - Rat Genome Database

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Gene: Usp43 (ubiquitin specific peptidase 43) Rattus norvegicus
Analyze
Symbol: Usp43
Name: ubiquitin specific peptidase 43
RGD ID: 2303824
Description: Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in protein deubiquitination and proteolysis. Orthologous to human USP43 (ubiquitin specific peptidase 43); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ubiquitin carboxyl-terminal hydrolase 43; ubiquitin specific protease 43
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81053,047,368 - 53,110,099 (-)NCBIGRCr8
mRatBN7.21052,549,200 - 52,611,168 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1052,548,963 - 52,611,533 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1057,217,546 - 57,279,931 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01056,706,555 - 56,768,942 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01052,205,582 - 52,267,722 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01054,406,980 - 54,467,956 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1054,406,980 - 54,467,956 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01054,153,291 - 54,213,556 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41054,591,669 - 54,653,842 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1051,729,378 - 51,789,193 (-)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 73 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp43Rat1,2-dimethylhydrazine increases expressionISOUsp43 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of USP43 mRNACTDPMID:22206623
Usp43Rat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISOUsp43 (Mus musculus)6480464[2 more ...CTDPMID:25510870
Usp43Rat2,2',5,5'-tetrachlorobiphenyl multiple interactionsISOUsp43 (Mus musculus)6480464[2 more ...CTDPMID:25510870
Usp43Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOUsp43 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of USP43 mRNACTDPMID:26377647
Usp43Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of USP43 mRNACTDPMID:32109520 and PMID:33387578
Usp43Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of USP43 mRNACTDPMID:24780913
Usp43Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of USP43 mRNACTDPMID:25825206
Usp43Ratacetamide increases expressionEXP 6480464acetamide results in increased expression of USP43 mRNACTDPMID:31881176
Usp43Rataflatoxin B1 affects expressionISOUSP43 (Homo sapiens)6480464Aflatoxin B1 affects the expression of USP43 proteinCTDPMID:20106945
Usp43Rataflatoxin B1 decreases expressionISOUSP43 (Homo sapiens)6480464Aflatoxin B1 results in decreased expression of USP43 mRNACTDPMID:22100608
Usp43Rataflatoxin B1 increases expressionISOUsp43 (Mus musculus)6480464Aflatoxin B1 results in increased expression of USP43 mRNACTDPMID:19770486
Usp43Rataristolochic acid A increases expressionISOUSP43 (Homo sapiens)6480464aristolochic acid I results in increased expression of USP43 mRNACTDPMID:33212167
Usp43Ratarsane affects methylationISOUSP43 (Homo sapiens)6480464Arsenic affects the methylation of USP43 geneCTDPMID:25304211
Usp43Ratarsenic atom affects methylationISOUSP43 (Homo sapiens)6480464Arsenic affects the methylation of USP43 geneCTDPMID:25304211
Usp43Ratbenzo[a]pyrene increases methylationISOUsp43 (Mus musculus)6480464Benzo(a)pyrene results in increased methylation of USP43 promoterCTDPMID:27901495
Usp43Ratbenzo[a]pyrene decreases expressionISOUSP43 (Homo sapiens)6480464Benzo(a)pyrene results in decreased expression of USP43 mRNACTDPMID:32234424
Usp43Ratbeta-lapachone decreases expressionISOUSP43 (Homo sapiens)6480464beta-lapachone results in decreased expression of USP43 mRNACTDPMID:38218311
Usp43Ratbis(2-ethylhexyl) phthalate increases expressionISOUSP43 (Homo sapiens)6480464Diethylhexyl Phthalate results in increased expression of USP43 mRNACTDPMID:31163220
Usp43Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of USP43 mRNACTDPMID:25181051 more ...
Usp43Ratbisphenol A decreases methylationISOUSP43 (Homo sapiens)6480464bisphenol A results in decreased methylation of USP43 geneCTDPMID:31601247

1 to 20 of 73 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp43Ratprotein deubiquitination involved_inIEAInterPro:IPR0013941600115GO_REF:0000002InterProGO_REF:0000002
Usp43Ratproteolysis involved_inIEAUniProtKB-KW:KW-06451600115GO_REF:0000043UniProtGO_REF:0000043

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp43Ratcysteine-type deubiquitinase activity enablesIEAInterPro:IPR001394 and InterPro:IPR0182001600115GO_REF:0000002InterProGO_REF:0000002
Usp43Ratcysteine-type peptidase activity enablesIEAUniProtKB-KW:KW-07881600115GO_REF:0000043UniProtGO_REF:0000043
Usp43Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Usp43Ratpeptidase activity enablesIEAUniProtKB-KW:KW-06451600115GO_REF:0000043UniProtGO_REF:0000043


#
Reference Title
Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:15632090  



Usp43
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81053,047,368 - 53,110,099 (-)NCBIGRCr8
mRatBN7.21052,549,200 - 52,611,168 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1052,548,963 - 52,611,533 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1057,217,546 - 57,279,931 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01056,706,555 - 56,768,942 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01052,205,582 - 52,267,722 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01054,406,980 - 54,467,956 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1054,406,980 - 54,467,956 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01054,153,291 - 54,213,556 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41054,591,669 - 54,653,842 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1051,729,378 - 51,789,193 (-)NCBICelera
Cytogenetic Map10q24NCBI
USP43
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38179,645,260 - 9,729,687 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl179,644,698 - 9,729,687 (+)EnsemblGRCh38hg38GRCh38
GRCh37179,548,834 - 9,633,004 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36179,489,675 - 9,573,729 (+)NCBINCBI36Build 36hg18NCBI36
Celera179,581,209 - 9,665,448 (+)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef179,449,765 - 9,533,827 (+)NCBIHuRef
CHM1_1179,559,106 - 9,643,235 (+)NCBICHM1_1
T2T-CHM13v2.0179,552,990 - 9,637,424 (+)NCBIT2T-CHM13v2.0
Usp43
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391167,745,349 - 67,812,979 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1167,745,349 - 67,812,979 (-)EnsemblGRCm39 Ensembl
GRCm381167,854,523 - 67,922,153 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1167,854,523 - 67,922,153 (-)EnsemblGRCm38mm10GRCm38
MGSCv371167,668,025 - 67,735,655 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361167,670,721 - 67,738,185 (-)NCBIMGSCv36mm8
Celera1174,798,281 - 74,860,275 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1141.13NCBI
Usp43
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554677,393,133 - 7,458,849 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554677,392,393 - 7,458,852 (-)NCBIChiLan1.0ChiLan1.0
USP43
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21964,021,442 - 64,107,448 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11768,831,222 - 68,915,662 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01741,927,406 - 42,012,712 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11746,670,551 - 46,755,722 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1746,671,245 - 46,753,915 (-)Ensemblpanpan1.1panPan2
USP43
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1534,136,066 - 34,186,593 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl534,135,252 - 34,186,591 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha534,272,304 - 34,322,645 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0534,240,207 - 34,290,610 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl534,240,207 - 34,290,606 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1534,206,149 - 34,256,452 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0534,163,904 - 34,214,530 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0534,344,421 - 34,395,013 (+)NCBIUU_Cfam_GSD_1.0
Usp43
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560249,156,660 - 49,230,910 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365952,631,714 - 2,704,356 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365952,631,589 - 2,704,903 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
USP43
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1254,584,343 - 54,641,116 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11254,584,386 - 54,643,921 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21257,342,309 - 57,399,795 (+)NCBISscrofa10.2Sscrofa10.2susScr3
USP43
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1169,002,297 - 9,084,408 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl169,002,594 - 9,083,711 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605912,257,633 - 12,340,788 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Usp43
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478612,050,297 - 12,118,106 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478612,050,201 - 12,118,119 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Usp43
387 total Variants

Predicted Target Of
Summary Value
Count of predictions:197
Count of miRNA genes:146
Interacting mature miRNAs:159
Transcripts:ENSRNOT00000065383
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 72 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103571058068663659Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104698969968663659Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105166340575085664Rat

1 to 10 of 72 rows
D10Mgh24  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81053,094,676 - 53,094,798 (+)Marker Load Pipeline
mRatBN7.21052,595,744 - 52,595,866 (+)MAPPERmRatBN7.2
Rnor_6.01054,452,824 - 54,452,945NCBIRnor6.0
Rnor_5.01054,198,992 - 54,199,113UniSTSRnor5.0
RGSC_v3.41054,638,646 - 54,638,768RGDRGSC3.4
RGSC_v3.41054,638,647 - 54,638,768UniSTSRGSC3.4
RGSC_v3.11054,652,270 - 54,652,391RGD
Celera1051,774,051 - 51,774,172UniSTS
RH 3.4 Map10583.9UniSTS
RH 3.4 Map10583.9RGD
Cytogenetic Map10q24UniSTS
RH130401  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21052,612,551 - 52,612,736 (+)MAPPERmRatBN7.2
Rnor_6.01054,469,625 - 54,469,809NCBIRnor6.0
Rnor_5.01054,215,225 - 54,215,409UniSTSRnor5.0
RGSC_v3.41054,656,244 - 54,656,428UniSTSRGSC3.4
Celera1051,790,861 - 51,791,045UniSTS
RH 3.4 Map10581.2UniSTS
Cytogenetic Map10q24UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 90 89 58 25 58 6 217 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000065383   ⟹   ENSRNOP00000062751
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1052,548,963 - 52,611,533 (-)Ensembl
Rnor_6.0 Ensembl1054,406,980 - 54,467,956 (-)Ensembl
RefSeq Acc Id: NM_001396024   ⟹   NP_001382953
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81053,048,158 - 53,110,099 (-)NCBI
mRatBN7.21052,549,218 - 52,611,168 (-)NCBI
RefSeq Acc Id: XM_039084979   ⟹   XP_038940907
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81053,047,368 - 53,109,981 (-)NCBI
mRatBN7.21052,549,200 - 52,611,084 (-)NCBI
Protein RefSeqs NP_001382953 (Get FASTA)   NCBI Sequence Viewer  
  XP_038940907 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM04798 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000062751
  ENSRNOP00000062751.2
  ENSRNOP00000102990
Ensembl Acc Id: ENSRNOP00000062751   ⟸   ENSRNOT00000065383
RefSeq Acc Id: XP_038940907   ⟸   XM_039084979
- Peptide Label: isoform X1
- UniProtKB: D3ZED6 (UniProtKB/TrEMBL),   A6HFJ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001382953   ⟸   NM_001396024
- UniProtKB: A6HFJ3 (UniProtKB/TrEMBL)
USP

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZED6-F1-model_v2 AlphaFold D3ZED6 1-1039 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 23 of 23 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-24642 BioCyc
Ensembl Genes ENSRNOG00000003785 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065383 ENTREZGENE
  ENSRNOT00000065383.4 UniProtKB/TrEMBL
  ENSRNOT00000157747 ENTREZGENE
Gene3D-CATH Cysteine proteinases UniProtKB/TrEMBL
InterPro Papain_like_cys_pep_sf UniProtKB/TrEMBL
  Pept_C19ubi-hydrolase_C_CS UniProtKB/TrEMBL
  Peptidase_C19 UniProtKB/TrEMBL
  Ub_carboxyl-term_hydrolase UniProtKB/TrEMBL
  UCH/PAN2 UniProtKB/TrEMBL
NCBI Gene 100147704 ENTREZGENE
PANTHER UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UniProtKB/TrEMBL
  UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 43 UniProtKB/TrEMBL
Pfam UCH UniProtKB/TrEMBL
PhenoGen Usp43 PhenoGen
PROSITE UCH_2_2 UniProtKB/TrEMBL
  UCH_2_3 UniProtKB/TrEMBL
  USP_1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003785 RatGTEx
Superfamily-SCOP SSF54001 UniProtKB/TrEMBL
UniProt A6HFJ3 ENTREZGENE, UniProtKB/TrEMBL
  D3ZED6 ENTREZGENE, UniProtKB/TrEMBL
1 to 23 of 23 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-02 Usp43  ubiquitin specific peptidase 43  Usp43_predicted  ubiquitin specific protease 43  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-02-27 Usp43_predicted  ubiquitin specific protease 43      Symbol and Name status set to provisional 70820 PROVISIONAL