Scarb1 (scavenger receptor class B, member 1) - Rat Genome Database

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Gene: Scarb1 (scavenger receptor class B, member 1) Rattus norvegicus
Analyze
Symbol: Scarb1
Name: scavenger receptor class B, member 1
RGD ID: 2302
Description: Enables identical protein binding activity and phosphatidylserine binding activity. Involved in several processes, including androgen biosynthetic process; recognition of apoptotic cell; and response to vitamin B3. Located in cell surface and microvillus membrane. Biomarker of end stage renal disease. Orthologous to human SCARB1 (scavenger receptor class B member 1); PARTICIPATES IN retinol metabolic pathway; reverse cholesterol transport pathway; bile acid transport pathway; INTERACTS WITH (+)-schisandrin B; (+)-taxifolin; (E)-thiamethoxam.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CD36 antigen (collagen type I receptor thrombospondin receptor)-like 1; CD36 antigen (collagen type I receptor thrombospondin receptor)-like 1 (scavanger receptor class B type 1); CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; Cd36l1; scavanger receptor class B type 1; scavenger receptor class B member 1; scavenger receptor class B type I; SR-B1; SR-BI; Srb1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81236,957,302 - 37,023,982 (+)NCBIGRCr8
mRatBN7.21231,296,143 - 31,362,649 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1231,296,156 - 31,362,647 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1232,468,363 - 32,534,776 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01233,079,673 - 33,146,089 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01232,131,509 - 32,197,925 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01236,694,952 - 36,761,445 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1236,694,960 - 36,761,455 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01238,572,152 - 38,638,465 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41232,390,183 - 32,457,661 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11232,253,570 - 32,321,047 (+)NCBI
Celera1232,988,597 - 33,054,666 (+)NCBICelera
Cytogenetic Map12q15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
Scarb1RatChemical and Drug Induced Liver Injury  IEP 401794432mRNA:increased expression:liver (rat)RGD 
Scarb1RatCoronary Disease  ISOScarb1 (Mus musculus)1580004 RGD 
Scarb1Ratend stage renal disease amelioratesIEP 2326081 RGD 
Scarb1RatHypercholesterolemia  ISOScarb1 (Mus musculus)1580004 RGD 
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Original Reference(s)
Scarb1RatAnimal Mammary Neoplasms  ISOSCARB1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12376462
Scarb1Ratcannabis abuse  ISOSCARB1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17205118
Scarb1Ratcarcinoma  ISOSCARB1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12376462
Scarb1RatCocaine-Related Disorders  ISOSCARB1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17205118
Scarb1Ratend stage renal disease  ISOSCARB1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19878707
Scarb1RatExperimental Mammary Neoplasms  ISOSCARB1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12376462
Scarb1RatFollicular Cyst  ISOSCARB1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20404351
Scarb1Rathepatitis C  ISOSCARB1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17517063
Scarb1Ratmetabolic dysfunction-associated steatotic liver disease  ISOSCARB1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23127599
Scarb1Ratphencyclidine abuse  ISOSCARB1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17205118
Scarb1Ratrenal cell carcinoma  ISOSCARB1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21131975
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Original Reference(s)
Scarb1Rat(+)-catechin multiple interactionsISOSCARB1 (Homo sapiens)6480464[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of SCARB1 mRNACTDPMID:24763279
Scarb1Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of SCARB1 mRNA]CTDPMID:31150632
Scarb1Rat(+)-taxifolin multiple interactionsEXP 6480464taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SCARB1 mRNA] and taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SCARB1 protein]CTDPMID:36198370
Scarb1Rat(1->4)-beta-D-glucan multiple interactionsISOScarb1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of SCARB1 mRNACTDPMID:36331819
Scarb1Rat(E)-thiamethoxam multiple interactionsEXP 6480464Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of SCARB1 mRNA]CTDPMID:34181816
Scarb1Rat(E)-thiamethoxam decreases expressionEXP 6480464Thiamethoxam results in decreased expression of SCARB1 mRNACTDPMID:34181816
Scarb1Rat(S)-nicotine multiple interactionsISOSCARB1 (Homo sapiens)6480464GW 3965 inhibits the reaction [Nicotine results in decreased expression of SCARB1 mRNA] more ...CTDPMID:30036686
Scarb1Rat(S)-nicotine decreases expressionEXP 6480464Nicotine results in decreased expression of SCARB1 mRNA and Nicotine results in decreased expression of SCARB1 proteinCTDPMID:30036686
Scarb1Rat(S)-nicotine decreases expressionISOSCARB1 (Homo sapiens)6480464Nicotine results in decreased expression of SCARB1 mRNA and Nicotine results in decreased expression of SCARB1 proteinCTDPMID:30036686
Scarb1Rat1,2-dichloroethane increases expressionISOScarb1 (Mus musculus)6480464ethylene dichloride results in increased expression of SCARB1 mRNACTDPMID:28189721 and PMID:28960355
Scarb1Rat1-naphthyl isothiocyanate multiple interactionsISOSCARB1 (Homo sapiens)6480464[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of SCARB1 mRNACTDPMID:27344345
Scarb1Rat14-Deoxy-11,12-didehydroandrographolide increases expressionISOSCARB1 (Homo sapiens)648046414-deoxy-11 and 12-didehydroandrographolide results in increased expression of SCARB1 mRNACTDPMID:22101062
Scarb1Rat17alpha-ethynylestradiol multiple interactionsISOSCARB1 (Homo sapiens)6480464[Ethinyl Estradiol affects the expression of TRA2B protein] which affects the splicing of SCARB1 mRNA more ...CTDPMID:17673517 and PMID:27344345
Scarb1Rat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of SCARB1 mRNA and Ethinyl Estradiol results in decreased expression of SCARB1 proteinCTDPMID:12475377 more ...
Scarb1Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of SCARB1 protein and Ethinyl Estradiol results in increased expression of SCARB1 protein modified formCTDPMID:12475377 and PMID:17673517
Scarb1Rat17alpha-ethynylestradiol affects splicingEXP 6480464Ethinyl Estradiol affects the splicing of SCARB1 mRNACTDPMID:17673517
Scarb1Rat17alpha-ethynylestradiol multiple interactionsEXP 6480464[Ethinyl Estradiol affects the expression of TRA2B protein] which affects the splicing of SCARB1 mRNACTDPMID:17673517
Scarb1Rat17alpha-ethynylestradiol affects splicingISOSCARB1 (Homo sapiens)6480464Ethinyl Estradiol affects the splicing of SCARB1 mRNACTDPMID:17673517
Scarb1Rat17beta-estradiol multiple interactionsISOSCARB1 (Homo sapiens)6480464Estradiol inhibits the reaction [Ritonavir results in increased expression of SCARB1 protein]CTDPMID:17879945
Scarb1Rat17beta-estradiol increases expressionISOScarb1 (Mus musculus)6480464Estradiol results in increased expression of SCARB1 mRNACTDPMID:39298647

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Biological Process
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Original Reference(s)
Scarb1Ratadhesion of symbiont to host involved_inIEAUniProtKB:Q8WTV0 and ensembl:ENSP000002616931600115GO_REF:0000107EnsemblGO_REF:0000107
Scarb1Rataflatoxin metabolic process  IEP 401794432 RGD 
Scarb1Ratandrogen biosynthetic process  IDA 1304382 RGD 
Scarb1Ratblood vessel endothelial cell migration acts_upstream_of_or_withinISOScarb1 (Mus musculus)1624291MGI:1888384 PMID:16339487RGDPMID:16339487
Scarb1Ratblood vessel endothelial cell migration acts_upstream_of_or_withinIEAUniProtKB:Q61009 and ensembl:ENSMUSP000000832421600115GO_REF:0000107EnsemblGO_REF:0000107
Scarb1Ratcholesterol catabolic process acts_upstream_of_or_withinISOScarb1 (Mus musculus)1624291MGI:1928989 PMID:10559220 and PMID:11278646RGDPMID:10559220 and PMID:11278646
Scarb1Ratcholesterol catabolic process acts_upstream_of_or_withinIEAUniProtKB:Q61009 and ensembl:ENSMUSP000000832421600115GO_REF:0000107EnsemblGO_REF:0000107
Scarb1Ratcholesterol efflux involved_inISOScarb1 (Mus musculus)1624291 PMID:14718538 and PMID:21481393RGDPMID:14718538 and PMID:21481393
Scarb1Ratcholesterol efflux involved_inIBAMGI:893578 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Scarb1Ratcholesterol efflux involved_inISOSCARB1 (Homo sapiens)1624291 PMID:12202492RGDPMID:12202492
Scarb1Ratcholesterol efflux involved_inIEAUniProtKB:Q61009 and ensembl:ENSMUSP000000832421600115GO_REF:0000107EnsemblGO_REF:0000107
Scarb1Ratcholesterol efflux involved_inIEAUniProtKB:Q8WTV0 and ensembl:ENSP000002616931600115GO_REF:0000107EnsemblGO_REF:0000107
Scarb1Ratcholesterol homeostasis involved_inISOScarb1 (Mus musculus)1624291 PMID:19136670RGDPMID:19136670
Scarb1Ratcholesterol homeostasis involved_inIEAUniProtKB:Q61009 and ensembl:ENSMUSP000000832421600115GO_REF:0000107EnsemblGO_REF:0000107
Scarb1Ratcholesterol import involved_inIEAUniProtKB:Q8WTV0 and ensembl:ENSP000002616931600115GO_REF:0000107EnsemblGO_REF:0000107
Scarb1Ratcholesterol import involved_inIBAMGI:893578 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Scarb1Ratcholesterol import involved_inISOScarb1 (Mus musculus)1624291 PMID:14718538 more ...RGDPMID:14718538 more ...
Scarb1Ratcholesterol import involved_inISOSCARB1 (Homo sapiens)1624291 PMID:11208913 and PMID:26965621RGDPMID:11208913 and PMID:26965621
Scarb1Ratcholesterol import involved_inIEAUniProtKB:Q61009 and ensembl:ENSMUSP000000832421600115GO_REF:0000107EnsemblGO_REF:0000107
Scarb1Ratcholesterol transport acts_upstream_of_or_withinIEAUniProtKB:Q61009 and ensembl:ENSMUSP000000832421600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Original Reference(s)
Scarb1Ratapical plasma membrane located_inISOSCARB1 (Sus scrofa)1624291 PMID:15140193 and PMID:16530456RGDPMID:15140193 and PMID:16530456
Scarb1Ratbasolateral plasma membrane located_inISOSCARB1 (Sus scrofa)1624291 PMID:16530456RGDPMID:16530456
Scarb1Ratcaveola located_inISOSCARB1 (Sus scrofa)1624291 PMID:15140193RGDPMID:15140193
Scarb1Ratcaveola located_inISOScarb1 (Mus musculus)1624291 PMID:9148942RGDPMID:9148942
Scarb1Ratcaveola is_active_inIBAMGI:893578 and PANTHER:PTN0026298741600115GO_REF:0000033GO_CentralGO_REF:0000033
Scarb1Ratcaveola located_inIEAUniProtKB:Q61009 and ensembl:ENSMUSP000000832421600115GO_REF:0000107EnsemblGO_REF:0000107
Scarb1Ratcaveola located_inIEAUniProtKB-SubCell:SL-00351600115GO_REF:0000044UniProtGO_REF:0000044
Scarb1Ratcell surface  IDA 1304237 RGD 
Scarb1Ratcell surface located_inISOScarb1 (Mus musculus)1624291 PMID:21481393RGDPMID:21481393
Scarb1Ratcell surface is_active_inIBAMGI:893578 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Scarb1Ratcell surface located_inIEAUniProtKB:Q61009 and ensembl:ENSMUSP000000832421600115GO_REF:0000107EnsemblGO_REF:0000107
Scarb1Ratcytoplasm located_inIEAUniProtKB:Q61009 and ensembl:ENSMUSP000000832421600115GO_REF:0000107EnsemblGO_REF:0000107
Scarb1Ratcytoplasm located_inISOScarb1 (Mus musculus)1624291 PMID:21481393RGDPMID:21481393
Scarb1Ratintracellular membrane-bounded organelle located_inISOSCARB1 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Scarb1Ratintracellular membrane-bounded organelle located_inIEAUniProtKB:Q8WTV0 and ensembl:ENSP000002616931600115GO_REF:0000107EnsemblGO_REF:0000107
Scarb1Ratlysosome located_inIEAUniProtKB:Q8WTV0 and ensembl:ENSP000002616931600115GO_REF:0000107EnsemblGO_REF:0000107
Scarb1Ratlysosome located_inISOSCARB1 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Scarb1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Scarb1Ratmembrane located_inISOScarb1 (Mus musculus)1624291 PMID:9148942RGDPMID:9148942
Scarb1Ratmembrane located_inIEAInterPro:IPR0021591600115GO_REF:0000002InterProGO_REF:0000002
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Molecular Function
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Scarb1Ratamyloid-beta binding enablesIEAUniProtKB:Q61009 and ensembl:ENSMUSP000000832421600115GO_REF:0000107EnsemblGO_REF:0000107
Scarb1Ratamyloid-beta binding enablesISOScarb1 (Mus musculus)1624291UniProtKB:P30204 and PMID:11240025RGDPMID:11240025
Scarb1Ratapolipoprotein A-I binding enablesIEAUniProtKB:Q8WTV0 and ensembl:ENSP000002616931600115GO_REF:0000107EnsemblGO_REF:0000107
Scarb1Ratapolipoprotein A-I binding enablesISOSCARB1 (Homo sapiens)1624291UniProtKB:P02647 more ...RGDPMID:10764676 and PMID:12651854
Scarb1Ratapolipoprotein binding enablesISOSCARB1 (Homo sapiens)1624291UniProtKB:P02652 and PMID:10764676RGDPMID:10764676
Scarb1Ratapolipoprotein binding enablesIEAUniProtKB:Q61009 and ensembl:ENSMUSP000000832421600115GO_REF:0000107EnsemblGO_REF:0000107
Scarb1Ratapolipoprotein binding enablesIEAUniProtKB:Q8WTV0 and ensembl:ENSP000002616931600115GO_REF:0000107EnsemblGO_REF:0000107
Scarb1Ratapolipoprotein binding enablesISOScarb1 (Mus musculus)1624291UniProtKB:P02656 and PMID:9254056RGDPMID:9254056
Scarb1Rathigh-density lipoprotein particle binding enablesIEAUniProtKB:Q61009 and ensembl:ENSMUSP000000832421600115GO_REF:0000107EnsemblGO_REF:0000107
Scarb1Rathigh-density lipoprotein particle binding enablesISOSCARB1 (Homo sapiens)1624291 PMID:11792700RGDPMID:11792700
Scarb1Rathigh-density lipoprotein particle binding enablesISOScarb1 (Mus musculus)1624291 PMID:14729860 and PMID:15210959RGDPMID:14729860 and PMID:15210959
Scarb1Rathigh-density lipoprotein particle binding enablesIEAUniProtKB:Q8WTV0 and ensembl:ENSP000002616931600115GO_REF:0000107EnsemblGO_REF:0000107
Scarb1Rathigh-density lipoprotein particle receptor activity enablesISSUniProtKB:Q8WTV01600115GO_REF:0000024BHF-UCLGO_REF:0000024
Scarb1Rathigh-density lipoprotein particle receptor activity enablesISOSCARB1 (Homo sapiens)1624291 PMID:11208913 more ...RGDPMID:11208913 more ...
Scarb1Rathigh-density lipoprotein particle receptor activity enablesIEAUniProtKB:Q8WTV0 and ensembl:ENSP000002616931600115GO_REF:0000107EnsemblGO_REF:0000107
Scarb1Rathigh-density lipoprotein particle receptor activity enablesISOSCARB1 (Sus scrofa)1624291 PMID:15140193RGDPMID:15140193
Scarb1Ratidentical protein binding  IPIScarb1 (Rattus norvegicus)1580003homodimerizationRGD 
Scarb1Ratlipid binding enablesIBAPANTHER:PTN002629874 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Scarb1Ratlipid transporter activity  TAS 1304382 RGD 
Scarb1Ratlipid transporter activity  TAS 1304217 RGD 
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RGD Manual Annotations


  

Imported Annotations - KEGG (archival)

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Original Reference(s)
Scarb1Ratbile acid transport pathway  IEA 6907045 KEGGrno:04976
Scarb1Rathepatitis C pathway  IEA 6907045 KEGGrno:05160
Scarb1Ratphagocytosis pathway  IEA 6907045 KEGGrno:04145

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Reference Title
Reference Citation
1. Hormonal regulation of adrenal microvillar channel formation. Azhar S, etal., J Lipid Res. 2002 Jun;43(6):861-71.
2. Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. Cho KH, etal., Biochim Biophys Acta. 2010 Jan;1800(1):6-15. Epub 2009 Oct 28.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Mechanisms involved in the intestinal absorption of dietary vitamin A and provitamin A carotenoids. Harrison EH Biochim Biophys Acta. 2012 Jan;1821(1):70-7. Epub 2011 Jun 12.
5. Characterization and chromosomal localization of rat scavenger receptor class B type I, a high density lipoprotein receptor with a putative leucine zipper domain and peroxisomal targeting sequence. Johnson MS, etal., Endocrinology 1998 Jan;139(1):72-80.
6. Phosphatidylserine binding of class B scavenger receptor type I, a phagocytosis receptor of testicular sertoli cells. Kawasaki Y, etal., J Biol Chem 2002 Jul 26;277(30):27559-66. Epub 2002 May 16.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Cloning, characterization, and cellular distribution of rat scavenger receptor class B type I (SRBI) in the ovary. Mizutani T, etal., Biochem Biophys Res Commun 1997 May 19;234(2):499-505.
9. Comparative effect of fish oil feeding and other dietary fatty acids on plasma lipoproteins, biliary lipids, and hepatic expression of proteins involved in reverse cholesterol transport in the rat. Morgado N, etal., Ann Nutr Metab. 2005 Nov-Dec;49(6):397-406. Epub 2005 Oct 14.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Reverse cholesterol transport and cholesterol efflux in atherosclerosis. Ohashi R, etal., QJM. 2005 Dec;98(12):845-56. Epub 2005 Oct 28.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. Dimerization of the scavenger receptor class B type I: formation, function, and localization in diverse cells and tissues. Reaven E, etal., J Lipid Res. 2004 Mar;45(3):513-28. Epub 2003 Dec 1.
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. The role of scavenger receptor class B type I (SR-BI) in lipid trafficking. defining the rules for lipid traders. Rhainds D and Brissette L, Int J Biochem Cell Biol. 2004 Jan;36(1):39-77.
19. Acute aflatoxin B1 - Induced hepatotoxicity alters gene expression and disrupts lipid and lipoprotein metabolism in rats. Rotimi OA, etal., Toxicol Rep. 2017 Jul 24;4:408-414. doi: 10.1016/j.toxrep.2017.07.006. eCollection 2017.
20. Role of class B scavenger receptor type I in phagocytosis of apoptotic rat spermatogenic cells by Sertoli cells. Shiratsuchi A, etal., J Biol Chem 1999 Feb 26;274(9):5901-8.
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PMID:8753864   PMID:9148942   PMID:9211901   PMID:9254056   PMID:10221589   PMID:10559220   PMID:10579331   PMID:10764676   PMID:10829064   PMID:11208913   PMID:11240025   PMID:11278646  
PMID:11792700   PMID:12202492   PMID:12477932   PMID:12493702   PMID:12562842   PMID:12651854   PMID:14652019   PMID:14694755   PMID:14718538   PMID:14729860   PMID:15140193   PMID:15206959  
PMID:15210842   PMID:15210959   PMID:15489334   PMID:16297529   PMID:16298471   PMID:16339487   PMID:16530182   PMID:16530456   PMID:16584836   PMID:17241464   PMID:17897319   PMID:17905649  
PMID:18079677   PMID:18175806   PMID:19041881   PMID:19087225   PMID:19122200   PMID:19136670   PMID:20458337   PMID:21481393   PMID:22767607   PMID:23197320   PMID:23482569   PMID:25701869  
PMID:25817199   PMID:26567857   PMID:26965621   PMID:27155079   PMID:27881715   PMID:27934803   PMID:28669731   PMID:31344978  



Scarb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81236,957,302 - 37,023,982 (+)NCBIGRCr8
mRatBN7.21231,296,143 - 31,362,649 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1231,296,156 - 31,362,647 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1232,468,363 - 32,534,776 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01233,079,673 - 33,146,089 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01232,131,509 - 32,197,925 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01236,694,952 - 36,761,445 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1236,694,960 - 36,761,455 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01238,572,152 - 38,638,465 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41232,390,183 - 32,457,661 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11232,253,570 - 32,321,047 (+)NCBI
Celera1232,988,597 - 33,054,666 (+)NCBICelera
Cytogenetic Map12q15NCBI
SCARB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812124,776,856 - 124,863,864 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12124,776,856 - 124,882,668 (-)EnsemblGRCh38hg38GRCh38
GRCh3712125,261,402 - 125,348,410 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612123,828,127 - 123,914,472 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412123,787,055 - 123,873,214NCBI
Celera12124,862,283 - 124,949,187 (-)NCBICelera
Cytogenetic Map12q24.31NCBI
HuRef12122,224,152 - 122,310,029 (-)NCBIHuRef
CHM1_112125,083,775 - 125,169,604 (-)NCBICHM1_1
T2T-CHM13v2.012124,782,134 - 124,869,001 (-)NCBIT2T-CHM13v2.0
Scarb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395125,354,151 - 125,418,082 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5125,354,151 - 125,418,158 (-)EnsemblGRCm39 Ensembl
GRCm385125,277,087 - 125,341,094 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5125,277,087 - 125,341,094 (-)EnsemblGRCm38mm10GRCm38
MGSCv375125,757,460 - 125,821,444 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365125,566,069 - 125,630,053 (-)NCBIMGSCv36mm8
Celera5122,296,944 - 122,361,197 (-)NCBICelera
Cytogenetic Map5G1.1NCBI
cM Map564.11NCBI
Scarb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554824,813,955 - 4,837,392 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554824,813,502 - 4,836,479 (+)NCBIChiLan1.0ChiLan1.0
SCARB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210132,858,215 - 132,987,046 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112132,782,925 - 132,944,486 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012122,293,803 - 122,455,314 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112126,651,077 - 126,698,506 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12126,659,532 - 126,694,767 (-)Ensemblpanpan1.1panPan2
SCARB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1265,035,797 - 5,122,383 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl265,049,407 - 5,121,468 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha265,195,714 - 5,282,186 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0265,282,168 - 5,368,989 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl265,295,032 - 5,368,981 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1265,217,039 - 5,303,430 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0265,308,627 - 5,394,876 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0265,260,548 - 5,347,101 (+)NCBIUU_Cfam_GSD_1.0
Scarb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118158,927,028 - 158,948,613 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936558530,828 - 552,892 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936558530,828 - 555,098 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCARB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1428,301,294 - 28,393,568 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11428,301,421 - 28,393,568 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21430,050,898 - 30,093,735 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SCARB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111120,134,485 - 120,223,512 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11120,134,874 - 120,216,904 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037125,058,937 - 125,145,319 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Scarb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474723,973,648 - 24,010,820 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474723,970,782 - 24,010,683 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Scarb1
397 total Variants


Assembly: RGSC_v3.4
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
12 32432437 32432438 G A snv SS/JrHsdMcwi (MCW) View more Information

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir455rno-miR-455-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23045399
Mir125arno-miR-125a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23045399
Mir125arno-miR-125a-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23045399

Predicted Target Of
Summary Value
Count of predictions:776
Count of miRNA genes:242
Interacting mature miRNAs:283
Transcripts:ENSRNOT00000001299, ENSRNOT00000001301, ENSRNOT00000064276
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 53 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122308134044726024Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122413920236638073Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat

1 to 10 of 53 rows
RH130563  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21231,338,775 - 31,338,990 (+)MAPPERmRatBN7.2
Rnor_6.01236,737,576 - 36,737,790NCBIRnor6.0
Rnor_5.01238,614,596 - 38,614,810UniSTSRnor5.0
RGSC_v3.41232,433,792 - 32,434,006UniSTSRGSC3.4
Celera1233,030,797 - 33,031,011UniSTS
RH 3.4 Map12567.91UniSTS
Cytogenetic Map12q15-q16UniSTS
RH134480  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21231,362,360 - 31,362,548 (-)MAPPERmRatBN7.2
mRatBN7.21231,362,360 - 31,362,548 (+)MAPPERmRatBN7.2
mRatBN7.2333,061,973 - 33,062,160 (+)MAPPERmRatBN7.2
Rnor_6.0332,805,794 - 32,805,980NCBIRnor6.0
Rnor_6.01236,761,157 - 36,761,344NCBIRnor6.0
Rnor_5.01238,638,177 - 38,638,364UniSTSRnor5.0
Rnor_5.0337,970,526 - 37,970,712UniSTSRnor5.0
RGSC_v3.41232,457,373 - 32,457,560UniSTSRGSC3.4
RGSC_v3.4329,564,155 - 29,564,341UniSTSRGSC3.4
Celera331,275,513 - 31,275,699UniSTS
Celera1233,054,378 - 33,054,565UniSTS
RH 3.4 Map12549.3UniSTS
Cytogenetic Map12q15-q16UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000001299   ⟹   ENSRNOP00000001299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1231,296,251 - 31,362,647 (+)Ensembl
Rnor_6.0 Ensembl1236,695,052 - 36,761,443 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000001301   ⟹   ENSRNOP00000001301
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1231,335,515 - 31,359,274 (+)Ensembl
Rnor_6.0 Ensembl1236,734,372 - 36,760,752 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000064276   ⟹   ENSRNOP00000060874
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1231,296,251 - 31,362,647 (+)Ensembl
Rnor_6.0 Ensembl1236,694,960 - 36,761,455 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110392   ⟹   ENSRNOP00000085701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1231,296,156 - 31,359,274 (+)Ensembl
RefSeq Acc Id: NM_031541   ⟹   NP_113729
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81236,957,496 - 37,023,982 (+)NCBI
mRatBN7.21231,296,156 - 31,362,649 (+)NCBI
Rnor_6.01236,694,957 - 36,761,445 (+)NCBI
Rnor_5.01238,572,152 - 38,638,465 (+)NCBI
RGSC_v3.41232,390,183 - 32,457,661 (+)RGD
Celera1232,988,597 - 33,054,666 (+)RGD
Sequence:
RefSeq Acc Id: XM_017598269   ⟹   XP_017453758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81236,957,302 - 37,023,982 (+)NCBI
mRatBN7.21231,296,167 - 31,362,649 (+)NCBI
Rnor_6.01236,694,952 - 36,761,445 (+)NCBI
Sequence:
RefSeq Acc Id: NP_113729   ⟸   NM_031541
- UniProtKB: P97943 (UniProtKB/Swiss-Prot),   A6J0X1 (UniProtKB/TrEMBL),   Q6SR89 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453758   ⟸   XM_017598269
- Peptide Label: isoform X1
- UniProtKB: G3V636 (UniProtKB/TrEMBL),   A6J0X0 (UniProtKB/TrEMBL),   Q6B4I7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001299   ⟸   ENSRNOT00000001299
Ensembl Acc Id: ENSRNOP00000001301   ⟸   ENSRNOT00000001301
Ensembl Acc Id: ENSRNOP00000060874   ⟸   ENSRNOT00000064276

Name Modeler Protein Id AA Range Protein Structure
AF-P97943-F1-model_v2 AlphaFold P97943 1-509 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698602
Promoter ID:EPDNEW_R9127
Type:initiation region
Name:Scarb1_1
Description:scavenger receptor class B, member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01236,695,033 - 36,695,093EPDNEW


1 to 25 of 25 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-19380 BioCyc
Ensembl Genes ENSRNOG00000000981 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000001299 ENTREZGENE
  ENSRNOT00000110392 ENTREZGENE
InterPro CD36/SCARB1/SNMP1 UniProtKB/Swiss-Prot
  CD36_fam UniProtKB/Swiss-Prot
KEGG Report rno:25073 UniProtKB/Swiss-Prot
NCBI Gene 25073 ENTREZGENE
PANTHER PTHR11923 UniProtKB/Swiss-Prot
  SCAVENGER RECEPTOR CLASS B MEMBER 1 UniProtKB/Swiss-Prot
Pfam CD36 UniProtKB/Swiss-Prot
PhenoGen Scarb1 PhenoGen
PRINTS CD36ANTIGEN UniProtKB/Swiss-Prot
  CD36FAMILY UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000981 RatGTEx
UniProt A0A8I6A220_RAT UniProtKB/TrEMBL
  A0A8L2QSW8_RAT UniProtKB/TrEMBL
  A6J0X0 ENTREZGENE, UniProtKB/TrEMBL
  A6J0X1 ENTREZGENE, UniProtKB/TrEMBL
  F8WFG6_RAT UniProtKB/TrEMBL
  G3V636 ENTREZGENE, UniProtKB/TrEMBL
  P97943 ENTREZGENE
  Q6B4I7 ENTREZGENE, UniProtKB/TrEMBL
  Q6SR89 ENTREZGENE, UniProtKB/TrEMBL
  SCRB1_RAT UniProtKB/Swiss-Prot
1 to 25 of 25 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Scarb1  scavenger receptor class B, member 1      Symbol and Name updated 629477 APPROVED
2003-03-17 Scarb1  scavenger receptor class B, member 1  Cd36l1  CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1  Symbol and Name updated to reflect Human and Mouse nomenclature 61478 PROVISIONAL
2001-06-12 Srb1  Scavanger receptor class B type 1      Symbol withdrawn, duplicate entry of Cd36l1 (RGD:2302) 62408 WITHDRAWN
2001-06-12 Cd36l1  CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1      Name updated 62408 APPROVED