Cbr1 (carbonyl reductase 1) - Rat Genome Database

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Gene: Cbr1 (carbonyl reductase 1) Rattus norvegicus
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Symbol: Cbr1 (Ensembl: Cbr1l3)
Name: carbonyl reductase 1 (Ensembl:carbonyl reductase 1 like 3)
RGD ID: 2286
Description: Enables carbonyl reductase (NADPH) activity. Involved in several processes, including lipid catabolic process; ovulation from ovarian follicle; and phylloquinone catabolic process. Located in microvillus. Biomarker of chronic kidney disease. Orthologous to human CBR1 (carbonyl reductase 1); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 15-hydroxyprostaglandin dehydrogenase; 20-beta-hydroxysteroid dehydrogenase; alcohol dehydrogenase [NAD(P)+] CBR1; carbonyl reductase; carbonyl reductase [NADPH] 1; Cbr; Cbr 1; MGC124927; NADPH-dependent carbonyl reductase 1; PG-9-KR; prostaglandin 9-ketoreductase; prostaglandin-E(2) 9-reductase
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81146,346,405 - 46,348,815 (+)NCBIGRCr8
mRatBN7.21132,860,571 - 32,862,981 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1132,857,991 - 32,895,275 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl1132,908,950 - 32,911,393 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl1132,985,707 - 32,992,000 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1141,554,857 - 41,557,234 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01134,226,398 - 34,228,775 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01133,387,189 - 33,389,552 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01133,813,041 - 33,815,418 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01137,436,992 - 37,439,368 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41133,787,957 - 33,790,320 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11133,844,199 - 33,846,562 (+)NCBI
Celera1132,503,106 - 32,505,469 (+)NCBICelera
RH 3.4 Map11 RGD
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cbr1Ratchronic kidney disease  IEP 11565077mRNA and protein:decreased expression:liverRGD 
Cbr1RatCOVID-19  ISOCBR1 (Homo sapiens)9068941mRNA:increased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226 and REF_RGD_ID:28912744
Cbr1RatExperimental Diabetes Mellitus  IEP 2302233protein:decreased expression:pancreas (rat)RGD 
Cbr1RatFever  IEP 2316279mRNA:decreased expression:liver and lungRGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
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Original Reference(s)
Cbr1Ratamyotrophic lateral sclerosis type 1  ISOCBR1 (Homo sapiens)8554872ClinVar Annotator: match by term: Amyotrophic lateral sclerosis type 1ClinVarPMID:17237124 more ...
Cbr1Ratautosomal dominant intellectual developmental disorder 7  ISOCBR1 (Homo sapiens)8554872ClinVar Annotator: match by term: DYRK1A-related intellectual disability syndromeClinVarPMID:17237124 more ...
Cbr1RatFamilial Platelet Disorder with Associated Myeloid Malignancy  ISOCBR1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary thrombocytopenia and hematological cancer predisposition syndrome associated with RUNX1ClinVarPMID:17237124 more ...
Cbr1Ratholocarboxylase synthetase deficiency  ISOCBR1 (Homo sapiens)8554872ClinVar Annotator: match by term: Holocarboxylase synthetase deficiencyClinVarPMID:28492532
Cbr1Ratimmunodeficiency 28  ISOCBR1 (Homo sapiens)8554872ClinVar Annotator: match by term: Immunodeficiency 28ClinVarPMID:17237124 more ...
Cbr1Ratthrombocytopenia  ISOCBR1 (Homo sapiens)8554872ClinVar Annotator: match by term: ThrombocytopeniaClinVarPMID:32581362
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
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Original Reference(s)
Cbr1Ratautism spectrum disorder  ISOCBR1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35663546
Cbr1Ratcardiomyopathy  ISOCBR1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11016643
Cbr1RatColonic Neoplasms  ISOCBR1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21056497
Cbr1Ratend stage renal disease  ISOCBR1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26282591
Cbr1Rathepatocellular carcinoma  ISOCBR1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21056497
Cbr1Ratirritant dermatitis  ISOCBR1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:25818598
Cbr1RatProstatic Neoplasms  ISOCBR1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17013881

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Object Symbol
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Original Reference(s)
Cbr1Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of CBR1 mRNA]CTDPMID:31150632
Cbr1Rat(1->4)-beta-D-glucan multiple interactionsISOCbr1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of CBR1 mRNACTDPMID:36331819
Cbr1Rat1,2-naphthoquinone multiple interactionsISOCBR1 (Homo sapiens)6480464[S-Nitrosoglutathione binds to CBR1 protein] promotes the reaction [CBR1 protein results in increased metabolism of 1 and 2-naphthoquinone]CTDPMID:23295225
Cbr1Rat1,4-dithiothreitol multiple interactionsISOCBR1 (Homo sapiens)6480464Dithiothreitol inhibits the reaction [S-Nitrosoglutathione inhibits the reaction [CBR1 protein results in increased reduction of S-Nitrosoglutathione]]CTDPMID:21256830
Cbr1Rat1,4-naphthoquinone multiple interactionsISOCBR1 (Homo sapiens)6480464[S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of 1 and 4-naphthoquinone]CTDPMID:23295225
Cbr1Rat13-dihydrodaunorubicin multiple interactionsISOCBR1 (Homo sapiens)6480464[[Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin] which results in decreased chemical synthesis of daunorubicinol more ...CTDPMID:20670211 and PMID:25541467
Cbr1Rat17alpha-ethynylestradiol affects expressionISOCbr1 (Mus musculus)6480464Ethinyl Estradiol affects the expression of CBR1 mRNACTDPMID:17555576
Cbr1Rat17alpha-ethynylestradiol increases expressionISOCbr1 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of CBR1 mRNACTDPMID:17942748
Cbr1Rat17alpha-ethynylestradiol multiple interactionsISOCbr1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CBR1 mRNACTDPMID:17942748
Cbr1Rat17beta-estradiol multiple interactionsEXP 6480464[bisphenol A co-treated with Estradiol] results in increased expression of CBR1 mRNACTDPMID:26496021
Cbr1Rat17beta-estradiol decreases expressionISOCbr1 (Mus musculus)6480464Estradiol results in decreased expression of CBR1 mRNACTDPMID:39298647
Cbr1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of CBR1 mRNACTDPMID:22298810
Cbr1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOCbr1 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of CBR1 mRNACTDPMID:18796159 and PMID:19933214
Cbr1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOCbr1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of CBR1 mRNACTDPMID:20702594 and PMID:21570461
Cbr1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOCbr1 (Mus musculus)6480464[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of CBR1 mRNA and [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CBR1 mRNACTDPMID:16214954 and PMID:17942748
Cbr1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of CBR1 proteinCTDPMID:19492234
Cbr1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of CBR1 mRNACTDPMID:33387578
Cbr1Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of CBR1 mRNACTDPMID:21346803
Cbr1Rat2,6-dimethoxyphenol multiple interactionsISOCBR1 (Homo sapiens)6480464[pyrogallol 1 more ...CTDPMID:38598786
Cbr1Rat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of CBR1 mRNACTDPMID:21346803

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Biological Process
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Original Reference(s)
Cbr1Ratepithelial cell differentiation involved_inISOCBR1 (Homo sapiens)1624291 PMID:21492153RGDPMID:21492153
Cbr1Ratglucocorticoid metabolic process involved_inISOCbr1 (Mus musculus)1624291 PMID:28878267RGDPMID:28878267
Cbr1Ratglucocorticoid metabolic process involved_inISOCBR1 (Homo sapiens)1624291 PMID:28878267RGDPMID:28878267
Cbr1Ratlipid metabolic process involved_inIEAUniProtKB-KW:KW-04431600115GO_REF:0000043UniProtGO_REF:0000043
Cbr1Ratovulation from ovarian follicle  IEP 1299856 RGD 
Cbr1Ratphylloquinone catabolic process  IDA 2316273menadione catabolismRGD 
Cbr1Ratpositive regulation of reactive oxygen species metabolic process involved_inISOCBR1 (Homo sapiens)1624291 PMID:19442656RGDPMID:19442656
Cbr1Ratprostaglandin catabolic process  IDA 69801 RGD 
Cbr1Ratresponse to estradiol  IDA 11565822 RGD 
Cbr1Ratresponse to gonadotropin  IEP 2316278 RGD 
Cbr1Ratresponse to lipopolysaccharide  IEP 2316279 RGD 
Cbr1Ratresponse to progesterone  IDA 11565822 RGD 
Cbr1Ratresponse to testosterone  IEP 2316271 RGD 
Cbr1Ratsteroid catabolic process  IDA 69801 RGD 
Cbr1Ratvitamin K metabolic process involved_inISSUniProtKB:P161521600115GO_REF:0000024UniProtGO_REF:0000024
Cbr1Ratvitamin K metabolic process involved_inISOCBR1 (Homo sapiens)1624291 PMID:18449627RGDPMID:18449627
Cbr1Ratxenobiotic metabolic process involved_inISOCBR1 (Homo sapiens)1624291 PMID:18449627RGDPMID:18449627
Cbr1Ratxenobiotic metabolic process involved_inISSUniProtKB:P161521600115GO_REF:0000024UniProtGO_REF:0000024
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Cellular Component

  
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Original Reference(s)
Cbr1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Cbr1Ratcytoplasm located_inIEAUniRule:UR0016277941600115GO_REF:0000104UniProtGO_REF:0000104
Cbr1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Cbr1Ratmicrovillus  IDA 2316271 RGD 

Molecular Function
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Original Reference(s)
Cbr1Rat15-hydroxyprostaglandin dehydrogenase (NADP+) activity enablesISSUniProtKB:Q289601600115GO_REF:0000024UniProtGO_REF:0000024
Cbr1Rat15-hydroxyprostaglandin dehydrogenase (NADP+) activity enablesIEARHEA:116361600115GO_REF:0000116RHEAGO_REF:0000116
Cbr1Rat15-hydroxyprostaglandin dehydrogenase (NADP+) activity enablesIEAEC:1.1.1.1971600115GO_REF:0000003UniProtGO_REF:0000003
Cbr1Rat15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity enablesIEAEC:1.1.1.1961600115GO_REF:0000003UniProtGO_REF:0000003
Cbr1Rat15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity enablesIEARHEA:207441600115GO_REF:0000116RHEAGO_REF:0000116
Cbr1Ratalcohol dehydrogenase (NADP+) activity enablesIEARHEA:159371600115GO_REF:0000116RHEAGO_REF:0000116
Cbr1Ratcarbonyl reductase (NADPH) activity  IDA 634703 RGD 
Cbr1Ratcarbonyl reductase (NADPH) activity enablesIEAEC:1.1.1.1841600115GO_REF:0000003UniProtGO_REF:0000003
Cbr1Ratcarbonyl reductase (NADPH) activity enablesIBAPANTHER:PTN001214843 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cbr1Ratcarbonyl reductase (NADPH) activity enablesIEARHEA:192571600115GO_REF:0000116RHEAGO_REF:0000116
Cbr1Ratcarbonyl reductase (NADPH) activity enablesISOCBR1 (Homo sapiens)1624291 PMID:18449627 and PMID:1921984RGDPMID:18449627 and PMID:1921984
Cbr1Ratcarbonyl reductase (NADPH) activity enablesIEAUniRule:UR0016277941600115GO_REF:0000104UniProtGO_REF:0000104
Cbr1Ratcarbonyl reductase (NADPH) activity enablesISSUniProtKB:P161521600115GO_REF:0000024UniProtGO_REF:0000024
Cbr1Ratcarbonyl reductase (NADPH) activity  IDA 69801 RGD 
Cbr1Ratoxidoreductase activity enablesIEAInterPro:IPR0209041600115GO_REF:0000002InterProGO_REF:0000002
Cbr1Ratoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
Cbr1Ratoxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor enablesISOCBR1 (Homo sapiens)1624291 PMID:19442656RGDPMID:19442656
Cbr1Ratoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor enablesISOCbr1 (Mus musculus)1624291 PMID:28878267RGDPMID:28878267
Cbr1Ratoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor enablesIEAARBA:ARBA000284421600115GO_REF:0000117UniProtGO_REF:0000117
Cbr1Ratoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor enablesIEAInterPro:IPR0453131600115GO_REF:0000002InterProGO_REF:0000002
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RGD Manual Annotations


  

Imported Annotations - SMPDB

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Original Reference(s)
Cbr1Ratacetylsalicylic acid pharmacodynamics pathway  ISOCBR1 (Homo sapiens)10402751 SMPDBSMP:00083
Cbr1Ratantipyrine drug pathway  ISOCBR1 (Homo sapiens)10402751 SMPDBSMP:00692
Cbr1Ratarachidonic acid metabolic pathway  ISOCBR1 (Homo sapiens)10402751 SMPDBSMP:00075
Cbr1Ratcelecoxib pharmacodynamics pathway  ISOCBR1 (Homo sapiens)10402751 SMPDBSMP:00096
Cbr1Ratdiclofenac pharmacodynamics pathway  ISOCBR1 (Homo sapiens)10402751 SMPDBSMP:00093
Cbr1Ratdiflunisal pharmacodynamics pathway  ISOCBR1 (Homo sapiens)10402751 SMPDBSMP:00289
Cbr1Ratdopa responsive dystonia pathway  ISOCBR1 (Homo sapiens)10402751 SMPDBSMP:00486
Cbr1Ratdoxorubicin pharmacokinetics pathway   ISOCBR1 (Homo sapiens)10402751 SMPDBSMP:00650
Cbr1Ratetodolac pharmacodynamics pathway  ISOCBR1 (Homo sapiens)10402751 SMPDBSMP:00084
Cbr1Ratfenoprofen pharmacodynamics pathway  ISOCBR1 (Homo sapiens)10402751 SMPDBSMP:00696
Cbr1Ratflurbiprofen pharmacodynamics pathway  ISOCBR1 (Homo sapiens)10402751 SMPDBSMP:00697
Cbr1Ratibuprofen pharmacodynamics pathway  ISOCBR1 (Homo sapiens)10402751 SMPDBSMP:00086
Cbr1Ratindometacin pharmacodynamics pathway  ISOCBR1 (Homo sapiens)10402751 SMPDBSMP:00104
Cbr1Ratindometacin pharmacodynamics pathway  ISOCBR1 (Homo sapiens)10402751 SMPDBSMP:00104
Cbr1Ratketoprofen pharmacodynamics pathway  ISOCBR1 (Homo sapiens)10402751 SMPDBSMP:00085
Cbr1Ratketorolac pharmacodynamics pathway  ISOCBR1 (Homo sapiens)10402751 SMPDBSMP:00098
Cbr1Ratleukotriene C4 synthase deficiency pathway  ISOCBR1 (Homo sapiens)10402751 SMPDBSMP:00353
Cbr1Ratlornoxicam pharmacodynamics pathway  ISOCBR1 (Homo sapiens)10402751 SMPDBSMP:00700
Cbr1Ratmagnesium salicylate pharmacodynamics pathway  ISOCBR1 (Homo sapiens)10402751 SMPDBSMP:00698
Cbr1Ratmefenamic acid pharmacodynamics pathway  ISOCBR1 (Homo sapiens)10402751 SMPDBSMP:00109
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Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
Cbr1Ratarachidonic acid metabolic pathway  IEA 6907045 KEGGrno:00590

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#
Reference Title
Reference Citation
1. Effect of experimental kidney disease on the functional expression of hepatic reductases. Alshogran OY, etal., Drug Metab Dispos. 2015 Jan;43(1):100-6. doi: 10.1124/dmd.114.061150. Epub 2014 Oct 20.
2. Identification of two closely related genes, inducible and noninducible carbonyl reductases in the rat ovary. Aoki H, etal., Biochem Biophys Res Commun 1997 Jan 23;230(3):518-23.
3. Effects of gonadectomy and steroid treatment on renal prostaglandin 9-ketoreductase activity in the rat. Cagen LM and Baer PG, Life Sci. 1987 Jan 5;40(1):95-100.
4. Temporal and spatial patterns of ovarian gene transcription following an ovulatory dose of gonadotropin in the rat. Espey LL and Richards JS, Biol Reprod. 2002 Dec;67(6):1662-70.
5. Characterization of ovarian carbonyl reductase gene expression during ovulation in the gonadotropin-primed immature Rat. Espey LL, etal., Biol Reprod 2000 Feb;62(2):390-7.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Differential hormonal regulation of carbonyl reductase activities in liver and kidney microsomes of rat. Imamura Y, etal., Xenobiotica 2002 Sep;32(9):729-37.
9. Expression of genes controlling transport and catabolism of prostaglandin E2 in lipopolysaccharide fever. Ivanov AI, etal., Am J Physiol Regul Integr Comp Physiol. 2003 Mar;284(3):R698-706. Epub 2002 Oct 24.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. Proteomic and transcriptomic analysis for streptozotocin-induced diabetic rat pancreas in response to fungal polysaccharide treatments. Kim SW, etal., Proteomics. 2008 Jun;8(11):2344-61.
12. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Synaptotagmin 11 interacts with components of the RNA-induced silencing complex RISC in clonal pancreatic beta-cells. Milochau A, etal., FEBS Lett. 2014 Jun 27;588(14):2217-22. doi: 10.1016/j.febslet.2014.05.031. Epub 2014 May 29.
15. New developments in anthracycline-induced cardiotoxicity. Mordente A, etal., Curr Med Chem. 2009;16(13):1656-72.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
18. GOA pipeline RGD automated data pipeline
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Mutation of threonine-241 to proline eliminates autocatalytic modification of human carbonyl reductase. Sciotti MA, etal., Biochem J. 2000 Aug 15;350 Pt 1:89-92.
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PMID:1597188   PMID:8198567   PMID:12477932   PMID:15489334   PMID:16855179   PMID:18449627   PMID:19056867   PMID:19199708   PMID:19442656   PMID:21492153   PMID:23376485   PMID:23533145  
PMID:24769233   PMID:25931508  



Cbr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81146,346,405 - 46,348,815 (+)NCBIGRCr8
mRatBN7.21132,860,571 - 32,862,981 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1132,857,991 - 32,895,275 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl1132,908,950 - 32,911,393 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl1132,985,707 - 32,992,000 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1141,554,857 - 41,557,234 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01134,226,398 - 34,228,775 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01133,387,189 - 33,389,552 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01133,813,041 - 33,815,418 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01137,436,992 - 37,439,368 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41133,787,957 - 33,790,320 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11133,844,199 - 33,846,562 (+)NCBI
Celera1132,503,106 - 32,505,469 (+)NCBICelera
RH 3.4 Map11 RGD
Cytogenetic Map11q11NCBI
CBR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382136,070,024 - 36,073,164 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2136,069,941 - 36,073,166 (+)EnsemblGRCh38hg38GRCh38
GRCh372137,442,322 - 37,445,462 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362136,364,155 - 36,367,332 (+)NCBINCBI36Build 36hg18NCBI36
Build 342136,364,154 - 36,367,332NCBI
Celera2122,641,173 - 22,644,350 (+)NCBICelera
Cytogenetic Map21q22.12NCBI
HuRef2122,920,731 - 22,923,910 (+)NCBIHuRef
CHM1_12137,004,079 - 37,007,256 (+)NCBICHM1_1
T2T-CHM13v2.02134,453,083 - 34,456,223 (+)NCBIT2T-CHM13v2.0
Cbr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391693,404,752 - 93,407,226 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1693,402,741 - 93,407,393 (+)EnsemblGRCm39 Ensembl
GRCm381693,607,837 - 93,610,349 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1693,605,853 - 93,610,505 (+)EnsemblGRCm38mm10GRCm38
MGSCv371693,608,082 - 93,610,594 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361693,496,379 - 93,498,862 (+)NCBIMGSCv36mm8
Celera1694,690,584 - 94,693,095 (+)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1654.53NCBI

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Variants in Cbr1
57 total Variants

Predicted Target Of
Summary Value
Count of predictions:72
Count of miRNA genes:54
Interacting mature miRNAs:54
Transcripts:ENSRNOT00000041838, ENSRNOT00000072384
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 16 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11135331169Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111945620576331918Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat

1 to 10 of 16 rows
RH129182  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01137,407,584 - 37,407,747NCBIRnor5.0
Rnor_5.01137,457,286 - 37,457,456NCBIRnor5.0
Rnor_5.01137,439,156 - 37,439,319NCBIRnor5.0
RGSC_v3.41133,790,109 - 33,790,271UniSTSRGSC3.4
RGSC_v3.41133,807,779 - 33,807,941UniSTSRGSC3.4
Celera1132,505,258 - 32,505,420UniSTS
Cytogenetic Map11q11UniSTS
RH142185  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01137,438,302 - 37,438,475NCBIRnor5.0
Rnor_5.01137,406,730 - 37,406,903NCBIRnor5.0
Rnor_5.01137,456,432 - 37,456,605NCBIRnor5.0
RGSC_v3.41133,806,925 - 33,807,097UniSTSRGSC3.4
RGSC_v3.41133,789,255 - 33,789,427UniSTSRGSC3.4
Celera1132,504,404 - 32,504,576UniSTS
RH 3.4 Map11248.5UniSTS
Cytogenetic Map11q11UniSTS
BE099783  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01137,437,874 - 37,438,929NCBIRnor5.0
Rnor_5.01137,406,301 - 37,407,357NCBIRnor5.0
Rnor_5.01137,456,003 - 37,457,059NCBIRnor5.0
RGSC_v3.41133,806,497 - 33,807,551UniSTSRGSC3.4
RGSC_v3.41133,788,826 - 33,789,881UniSTSRGSC3.4
Celera1132,503,975 - 32,505,030UniSTS
RH 3.4 Map3208.9UniSTS
Cytogenetic Map11q11UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
4 11 43 83 56 59 40 20 40 161 74 75 35 41 19



Ensembl Acc Id: ENSRNOT00000041838   ⟹   ENSRNOP00000051107
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1132,985,707 - 32,992,000 (+)Ensembl
Rnor_6.0 Ensembl1133,845,463 - 33,847,793 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000042283   ⟹   ENSRNOP00000043385
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1133,812,989 - 33,815,418 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000075985   ⟹   ENSRNOP00000067964
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1133,813,043 - 33,815,418 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1132,908,950 - 32,911,393 (+)Ensembl
RefSeq Acc Id: NM_019170   ⟹   NP_062043
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81146,346,405 - 46,348,815 (+)NCBI
mRatBN7.21132,860,571 - 32,862,981 (+)NCBI
Rnor_6.01133,813,041 - 33,815,418 (+)NCBI
Rnor_5.01137,436,992 - 37,439,368 (+)NCBI
RGSC_v3.41133,787,957 - 33,790,320 (+)RGD
Celera1132,503,106 - 32,505,469 (+)RGD
Sequence:
Protein RefSeqs NP_062043 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF03395 (Get FASTA)   NCBI Sequence Viewer  
  AAI05894 (Get FASTA)   NCBI Sequence Viewer  
  BAA19008 (Get FASTA)   NCBI Sequence Viewer  
  CAA59088 (Get FASTA)   NCBI Sequence Viewer  
  CAA65230 (Get FASTA)   NCBI Sequence Viewer  
  EDM10787 (Get FASTA)   NCBI Sequence Viewer  
  P47727 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062043   ⟸   NM_019170
- UniProtKB: Q3KR58 (UniProtKB/Swiss-Prot),   P47727 (UniProtKB/Swiss-Prot),   O08558 (UniProtKB/Swiss-Prot),   A6JLM2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000051107   ⟸   ENSRNOT00000041838
Ensembl Acc Id: ENSRNOP00000043385   ⟸   ENSRNOT00000042283
Ensembl Acc Id: ENSRNOP00000067964   ⟸   ENSRNOT00000075985

Name Modeler Protein Id AA Range Protein Structure
AF-P47727-F1-model_v2 AlphaFold P47727 1-277 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 36 of 36 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-21812 BioCyc
Ensembl Genes ENSRNOG00000047848 Ensembl
  ENSRNOG00000049693 Ensembl
  ENSRNOG00000049911 Ensembl
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7366019 IMAGE-MGC_LOAD
InterPro CBR1-like UniProtKB/Swiss-Prot
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
  Sc_DH/Rdtase_CS UniProtKB/Swiss-Prot
  SDR_fam UniProtKB/Swiss-Prot
KEGG Report rno:29224 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124927 IMAGE-MGC_LOAD
NCBI Gene Cbr1 ENTREZGENE
PANTHER CARBONYL REDUCTASE 1-RELATED UniProtKB/Swiss-Prot
  CARBONYL REDUCTASE [NADPH] 1 UniProtKB/Swiss-Prot
Pfam adh_short UniProtKB/Swiss-Prot
PharmGKB CBR1 RGD
PhenoGen Cbr1 PhenoGen
PRINTS GDHRDH UniProtKB/Swiss-Prot
  SDRFAMILY UniProtKB/Swiss-Prot
PROSITE ADH_SHORT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000047848 RatGTEx
  ENSRNOG00000049693 RatGTEx
  ENSRNOG00000049911 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot
UniProt A0A096MJ24_RAT UniProtKB/TrEMBL
  A0A0G2K658_RAT UniProtKB/TrEMBL
  A0A8I5XVU2_RAT UniProtKB/TrEMBL
  A0A8I5ZT21_RAT UniProtKB/TrEMBL
  A6JLM2 ENTREZGENE, UniProtKB/TrEMBL
  CBR1_RAT UniProtKB/Swiss-Prot
  O08558 ENTREZGENE
  P47727 ENTREZGENE
  Q3KR58 ENTREZGENE
UniProt Secondary O08558 UniProtKB/Swiss-Prot
  Q3KR58 UniProtKB/Swiss-Prot
1 to 36 of 36 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-02-24 Cbr1  carbonyl reductase 1  Cbr1l1  carbonyl reductase 1 like 1  Name and Symbol changed 629549 APPROVED
2022-10-18 Cbr1l1  carbonyl reductase 1 like 1  Cbr1  carbonyl reductase 1  Name and Symbol changed 629549 APPROVED
2002-06-10 Cbr1  carbonyl reductase 1      Symbol and Name status set to approved 70586 APPROVED
2001-12-06 Cbr 1  carbonyl reductase 1      Symbol and Name updated to reflect Human and Mouse nomenclature 69665 APPROVED

Note Type Note Reference
gene_expression expressed in testis and ovaries 634702
gene_expression expressed in liver and kidneys 634703
gene_function NADPH-dependent oxidoreductase 69801
gene_function recombinant enzyme catalyzes its own modification by 2-oxoglutarate 69801
gene_process may be involved in ovarian follicular development 634702
gene_process may be involved in ovarian follicular development 1299856