Brca1 (BRCA1, DNA repair associated) - Rat Genome Database

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Gene: Brca1 (BRCA1, DNA repair associated) Rattus norvegicus
Analyze
Symbol: Brca1
Name: BRCA1, DNA repair associated
RGD ID: 2218
Description: Enables chromatin binding activity. Involved in several processes, including positive regulation of protein import into nucleus; response to estradiol; and response to genistein. Located in mitochondrial matrix. Biomarker of ductal carcinoma in situ. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia complementation group S; breast cancer (multiple); cervix uteri carcinoma in situ; gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human BRCA1 (BRCA1 DNA repair associated); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; forkhead class A signaling pathway; homologous recombination pathway of double-strand break repair; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BRCA-1; breast cancer 1; breast cancer 1, early onset; breast cancer type 1 susceptibility protein homolog; RING-type E3 ubiquitin transferase BRCA1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Brca1m1Uwm   Brca1em1Kyo  
Genetic Models: SD-Brca1m1Uwm SD-Brca1em1Kyo
Is Marker For: Strains:   SD   SD-Brca1m1Uwm  
Candidate Gene For: Mcs15
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,917,693 - 86,978,012 (-)NCBIGRCr8
mRatBN7.21086,417,441 - 86,477,762 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,418,000 - 86,477,304 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1091,454,623 - 91,513,795 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,930,035 - 90,990,102 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,323,338 - 86,383,395 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,394,821 - 89,455,093 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,394,803 - 89,454,681 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01089,192,653 - 89,252,760 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,513,630 - 90,572,676 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11090,527,999 - 90,587,046 (-)NCBI
Celera1085,140,052 - 85,200,670 (-)NCBICelera
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Object Symbol
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Original Reference(s)
Brca1Ratbreast adenocarcinoma treatmentISOBRCA1 (Homo sapiens)126925966 RGD 
Brca1Ratbreast cancer susceptibilityISOBRCA1 (Homo sapiens)1599497DNA:mutationRGD 
Brca1Ratbreast cancer  ISOBRCA1 (Homo sapiens)126925963mRNA and protein:splice variantRGD 
Brca1Ratbreast cancer  ISOBRCA1 (Homo sapiens)127284852DNA:loss of heterozygosity more ...RGD 
Brca1Ratbreast cancer  ISOBRCA1 (Homo sapiens)2293151DNA:hypermethylation:promoterRGD 
Brca1Ratbreast cancer  ISOBRCA1 (Homo sapiens)734655 RGD 
Brca1Ratbreast cancer susceptibilityISOBRCA1 (Homo sapiens)2293153mRNA:allelic imbalance:lymphocyteRGD 
Brca1Ratbreast carcinoma disease_progressionISOBRCA1 (Homo sapiens)2293150protein:altered localization:cytoplasmRGD 
Brca1Ratcervical cancer disease_progressionISOBRCA1 (Homo sapiens)2298941DNA:hypermethylation:promoterRGD 
Brca1Ratcervix uteri carcinoma in situ  ISOBRCA1 (Homo sapiens)2298942DNA:deletions:exonRGD 
Brca1Ratcolon cancer susceptibilityISOBRCA1 (Homo sapiens)1599497DNA:mutationRGD 
Brca1Ratcolon cancer disease_progressionISOBRCA1 (Homo sapiens)126925959 RGD 
Brca1Ratcolorectal cancer disease_progressionISOBRCA1 (Homo sapiens)126790575 RGD 
Brca1Ratcolorectal cancer onsetISOBRCA1 (Homo sapiens)126925961 RGD 
Brca1Ratcolorectal carcinoma  ISOBRCA1 (Homo sapiens)126925969 RGD 
Brca1Ratductal carcinoma in situ treatmentIEP 127284854 RGD 
Brca1Ratesophagus squamous cell carcinoma  ISOBRCA1 (Homo sapiens)126925960DNA:SNP: :rs799917 (human)RGD 
Brca1RatExperimental Mammary Neoplasms  IEP 1599502 RGD 
Brca1RatExperimental Mammary Neoplasms  ISOBRCA1 (Homo sapiens)2293155 RGD 
Brca1RatExperimental Mammary Neoplasms susceptibilityISOBrca1 (Mus musculus)2293149 RGD 
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Original Reference(s)
Brca1Ratbilateral breast cancer  ISOBRCA1 (Homo sapiens)8554872ClinVar Annotator: match by term: bilateral breast cancerClinVarPMID:11376024 more ...
Brca1Ratbreast cancer  ISOBRCA1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25652403 more ...
Brca1Ratbreast cancer  ISOBRCA1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:30728895 more ...
Brca1Ratbreast cancer  ISOBRCA1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10090482 more ...
Brca1Ratbreast cancer  ISOBRCA1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:18512148 more ...
Brca1Ratbreast cancer  ISOBRCA1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:30765603 more ...
Brca1Ratbreast cancer  ISOBRCA1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25652403 more ...
Brca1Ratbreast cancer  ISOBRCA1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:30875412 more ...
Brca1Ratbreast cancer  ISOBRCA1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:31112341 more ...
Brca1Ratbreast cancer  ISOBRCA1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25748678 more ...
Brca1Ratbreast cancer  ISOBRCA1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:18546071 more ...
Brca1Ratbreast cancer  ISOBRCA1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10090482 more ...
Brca1Ratbreast cancer  ISOBRCA1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25980754 more ...
Brca1Ratbreast cancer  ISOBRCA1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:18694767 more ...
Brca1Ratbreast cancer  ISOBRCA1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10090482 more ...
Brca1Ratbreast cancer  ISOBRCA1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:31451522 more ...
Brca1Ratbreast cancer  ISOBRCA1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:31815095 more ...
Brca1Ratbreast cancer  ISOBRCA1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:31843900 more ...
Brca1Ratbreast cancer  ISOBRCA1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:26026974 more ...
Brca1Ratbreast cancer  ISOBRCA1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:31843900 more ...
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Original Reference(s)
Brca1Ratadenoid cystic carcinoma  ISOBRCA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23685749
Brca1RatAnimal Mammary Neoplasms  ISOBRCA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12203372
Brca1RatBreast Neoplasms  ISOBRCA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:7894491 more ...
Brca1Ratcarcinoma  ISOBRCA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12203372
Brca1RatChromosome Breakage  ISOBRCA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15894690
Brca1Ratdisease of cellular proliferation  ISOBRCA1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:15520196
Brca1RatExperimental Mammary Neoplasms  ISOBRCA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12203372 and PMID:22767648
Brca1Rathereditary breast ovarian cancer syndrome  ISOBRCA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:8644702 and PMID:21597964
Brca1Ratmouth disease  ISOBRCA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17682004
Brca1RatNeoplastic Cell Transformation  ISOBRCA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22048643
Brca1RatOvarian Neoplasms  ISOBRCA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:7795652 more ...
Brca1Ratpancreatic cancer  ISOBRCA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26098869
Brca1RatProstatic Neoplasms  ISOBRCA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17585057
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Original Reference(s)
Brca1Ratbreast cancer  ISSBRCA1 (Homo sapiens)13592920OMIM:114480MouseDO 

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Original Reference(s)
Brca1Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of BRCA1 mRNA]CTDPMID:31150632
Brca1Rat(-)-alpha-phellandrene decreases expressionISOBrca1 (Mus musculus)6480464alpha phellandrene results in decreased expression of BRCA1 proteinCTDPMID:24861204
Brca1Rat(-)-epigallocatechin 3-gallate multiple interactionsISOBRCA1 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of BRCA1 mRNACTDPMID:22079256
Brca1Rat(-)-epigallocatechin 3-gallate increases expressionISOBRCA1 (Homo sapiens)6480464epigallocatechin gallate results in increased expression of BRCA1 mRNACTDPMID:25839702
Brca1Rat(S)-naringenin multiple interactionsISOBRCA1 (Homo sapiens)6480464[naringenin co-treated with bisphenol A] results in increased expression of BRCA1 mRNA and [naringenin metabolite co-treated with bisphenol A] results in increased expression of BRCA1 mRNACTDPMID:36235125
Brca1Rat(S)-nicotine decreases expressionISOBRCA1 (Homo sapiens)6480464Nicotine results in decreased expression of BRCA1 mRNACTDPMID:18247414
Brca1Rat(S)-nicotine multiple interactionsISOBRCA1 (Homo sapiens)6480464Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of BRCA1 protein modified form]CTDPMID:23907605
Brca1Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expressionISOBRCA1 (Homo sapiens)6480464o and p'-DDT results in increased expression of BRCA1 mRNACTDPMID:20206645
Brca1Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane multiple interactionsISOBRCA1 (Homo sapiens)64804642-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [o more ...CTDPMID:20206645
Brca1Rat1,1-dichloroethene increases expressionISOBrca1 (Mus musculus)6480464vinylidene chloride results in increased expression of BRCA1 mRNACTDPMID:26682919
Brca1Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of BRCA1 mRNACTDPMID:30723492
Brca1Rat1-nitropyrene decreases expressionISOBRCA1 (Homo sapiens)64804641-nitropyrene results in decreased expression of BRCA1 mRNACTDPMID:21540303
Brca1Rat17beta-estradiol increases expressionISOBrca1 (Mus musculus)6480464Estradiol results in increased expression of BRCA1 mRNACTDPMID:25210133
Brca1Rat17beta-estradiol decreases expressionISOBrca1 (Mus musculus)6480464Estradiol results in decreased expression of BRCA1 mRNACTDPMID:39298647
Brca1Rat17beta-estradiol decreases expressionISOBRCA1 (Homo sapiens)6480464Estradiol results in decreased expression of BRCA1 mRNACTDPMID:23373633
Brca1Rat17beta-estradiol increases expressionISOBRCA1 (Homo sapiens)6480464Estradiol results in increased expression of BRCA1 mRNA and Estradiol results in increased expression of BRCA1 proteinCTDPMID:12473173 more ...
Brca1Rat17beta-estradiol affects localizationISOBRCA1 (Homo sapiens)6480464Estradiol affects the localization of BRCA1 proteinCTDPMID:16061635
Brca1Rat17beta-estradiol multiple interactionsISOBRCA1 (Homo sapiens)64804642 more ...CTDPMID:11110848 more ...
Brca1Rat17beta-hydroxy-17-methylestra-4,9,11-trien-3-one increases expressionISOBRCA1 (Homo sapiens)6480464Metribolone results in increased expression of BRCA1 mRNACTDPMID:17010196
Brca1Rat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISOBRCA1 (Homo sapiens)64804642 more ...CTDPMID:12473173

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Biological Process
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Original Reference(s)
Brca1Ratcellular response to indole-3-methanol involved_inISOBRCA1 (Homo sapiens)1624291 PMID:10868478RGDPMID:10868478
Brca1Ratcellular response to ionizing radiation involved_inISOBRCA1 (Homo sapiens)1624291 PMID:14636569RGDPMID:14636569
Brca1Ratcellular response to tumor necrosis factor involved_inISOBRCA1 (Homo sapiens)1624291 PMID:23415688RGDPMID:23415688
Brca1Ratcentrosome cycle acts_upstream_of_or_withinISOBrca1 (Mus musculus)1624291MGI:107799 PMID:15123655RGDPMID:15123655
Brca1Ratchordate embryonic development involved_inIBAMGI:104537 and PANTHER:PTN0003491421600115GO_REF:0000033GO_CentralGO_REF:0000033
Brca1Ratchordate embryonic development acts_upstream_of_or_withinISOBrca1 (Mus musculus)1624291MGI:1930613 PMID:9171368RGDPMID:9171368
Brca1Ratchromosome segregation involved_inISOBRCA1 (Homo sapiens)1624291 PMID:15965487RGDPMID:15965487
Brca1RatDNA damage response involved_inIEAInterPro:IPR0310991600115GO_REF:0000002InterProGO_REF:0000002
Brca1RatDNA damage response involved_inIEAUniProtKB-KW:KW-02271600115GO_REF:0000043UniProtGO_REF:0000043
Brca1RatDNA damage response acts_upstream_of_or_withinISOBrca1 (Mus musculus)1624291MGI:3696057 PMID:23271346RGDPMID:23271346
Brca1RatDNA recombination involved_inIEAUniProtKB-KW:KW-02331600115GO_REF:0000043UniProtGO_REF:0000043
Brca1RatDNA repair involved_inIEAUniProtKB-KW:KW-02341600115GO_REF:0000043UniProtGO_REF:0000043
Brca1RatDNA repair involved_inIEAInterPro:IPR011364 and InterPro:IPR0310991600115GO_REF:0000002InterProGO_REF:0000002
Brca1Ratdouble-strand break repair involved_inISOBRCA1 (Homo sapiens)1624291 PMID:17525340 more ...RGDPMID:17525340 more ...
Brca1Ratdouble-strand break repair involved_inISOBrca1 (Mus musculus)1624291 PMID:22186889RGDPMID:22186889
Brca1Ratdouble-strand break repair via homologous recombination involved_inISOBRCA1 (Homo sapiens)1624291 PMID:17349954 and PMID:28398198RGDPMID:17349954 and PMID:28398198
Brca1Ratdouble-strand break repair via homologous recombination involved_inIBAPANTHER:PTN000349139 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Brca1Ratfatty acid biosynthetic process involved_inIEAUniProtKB-KW:KW-02751600115GO_REF:0000043UniProtGO_REF:0000043
Brca1Ratfatty acid metabolic process involved_inIEAUniProtKB-KW:KW-02761600115GO_REF:0000043UniProtGO_REF:0000043
Brca1Ratintrinsic apoptotic signaling pathway in response to DNA damage acts_upstream_of_or_withinISOBRCA1 (Homo sapiens)1624291 PMID:14654789RGDPMID:14654789
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Cellular Component
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Original Reference(s)
Brca1RatBRCA1-A complex part_ofISOBRCA1 (Homo sapiens)1624291 PMID:17525340 more ...RGDPMID:17525340 more ...
Brca1RatBRCA1-A complex part_ofIBAPANTHER:PTN000349139 and UniProtKB:P383981600115GO_REF:0000033GO_CentralGO_REF:0000033
Brca1RatBRCA1-B complex part_ofISOBRCA1 (Homo sapiens)1624291 PMID:16391231RGDPMID:16391231
Brca1RatBRCA1-BARD1 complex part_ofISSUniProtKB:P383981600115GO_REF:0000024UniProtGO_REF:0000024
Brca1RatBRCA1-BARD1 complex part_ofIBAPANTHER:PTN000349139 and UniProtKB:P383981600115GO_REF:0000033GO_CentralGO_REF:0000033
Brca1RatBRCA1-BARD1 complex part_ofISOBRCA1 (Homo sapiens)1624291 PMID:11573085 more ...RGDPMID:11573085 more ...
Brca1RatBRCA1-BARD1 complex part_ofIEAUniRule:UR0001487591600115GO_REF:0000104UniProtGO_REF:0000104
Brca1RatBRCA1-C complex part_ofISOBRCA1 (Homo sapiens)1624291 PMID:16391231RGDPMID:16391231
Brca1Ratchromosome located_inIEAUniProtKB-SubCell:SL-04681600115GO_REF:0000044UniProtGO_REF:0000044
Brca1Ratchromosome located_inISOBrca1 (Mus musculus)1624291 PMID:22549958 and PMID:23039116RGDPMID:22549958 and PMID:23039116
Brca1Ratchromosome located_inIEAUniProtKB-KW:KW-01581600115GO_REF:0000043UniProtGO_REF:0000043
Brca1Ratchromosome located_inIEAUniRule:UR0001487591600115GO_REF:0000104UniProtGO_REF:0000104
Brca1Ratchromosome located_inISSUniProtKB:P487541600115GO_REF:0000024UniProtGO_REF:0000024
Brca1Ratcondensed chromosome located_inISOBrca1 (Mus musculus)1624291 PMID:12913077RGDPMID:12913077
Brca1Ratcondensed nuclear chromosome located_inISOBrca1 (Mus musculus)1624291 PMID:20551173 and PMID:26490168RGDPMID:20551173 and PMID:26490168
Brca1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Brca1Ratcytoplasm located_inISOBrca1 (Mus musculus)1624291 PMID:11172592RGDPMID:11172592
Brca1Ratcytoplasm located_inISOBRCA1 (Homo sapiens)1624291 PMID:20160719RGDPMID:20160719
Brca1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Brca1RatDNA repair complex part_ofISOBRCA1 (Homo sapiens)1624291 PMID:19369211RGDPMID:19369211
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Molecular Function
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Original Reference(s)
Brca1Ratchromatin binding  IDA 9586065 RGD 
Brca1Ratdamaged DNA binding enablesISOBrca1 (Mus musculus)1624291 PMID:11934988RGDPMID:11934988
Brca1RatDNA binding enablesIEAUniProtKB-KW:KW-02381600115GO_REF:0000043UniProtGO_REF:0000043
Brca1RatDNA binding enablesIEAInterPro:IPR0113641600115GO_REF:0000002InterProGO_REF:0000002
Brca1Ratenzyme binding enablesISOBRCA1 (Homo sapiens)1624291UniProtKB:P11388 and PMID:15965487RGDPMID:15965487
Brca1Ratidentical protein binding enablesISOBRCA1 (Homo sapiens)1624291UniProtKB:P38398 more ...RGDPMID:29656893 more ...
Brca1Ratmetal ion binding enablesIEAInterPro:IPR0189571600115GO_REF:0000002InterProGO_REF:0000002
Brca1Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Brca1Ratp53 binding enablesISOBRCA1 (Homo sapiens)1624291 PMID:15571721RGDPMID:15571721
Brca1Ratprotein binding  IPIVdr (Rattus norvegicus)10059411 RGD 
Brca1Ratprotein binding enablesISOBRCA1 (Homo sapiens)1624291UniProtKB:O14757 more ...RGDPMID:10477523 more ...
Brca1Ratprotein binding enablesISOBRCA1 (Homo sapiens) and UniProtKB:P38398-51624291UniProtKB:Q92560 and PMID:9528852RGDPMID:9528852
Brca1Ratprotein binding enablesISOBRCA1 (Homo sapiens) and UniProtKB:P38398-11624291UniProtKB:Q13526 more ...RGDPMID:31270457
Brca1Ratprotein binding enablesISOBRCA1 (Homo sapiens) and UniProtKB:P38398-61624291UniProtKB:P42858 more ...RGDPMID:32814053
Brca1RatRNA binding enablesISOBRCA1 (Homo sapiens)1624291 PMID:12419249RGDPMID:12419249
Brca1RatRNA polymerase binding enablesISSUniProtKB:P383981600115GO_REF:0000024UniProtGO_REF:0000024
Brca1RatRNA polymerase binding enablesISOBRCA1 (Homo sapiens)1624291 PMID:9662397RGDPMID:9662397
Brca1Rattranscription cis-regulatory region binding enablesISOBrca1 (Mus musculus)1624291 PMID:20820192RGDPMID:20820192
Brca1Rattranscription cis-regulatory region binding enablesISOBRCA1 (Homo sapiens)1624291 PMID:20820192RGDPMID:20820192
Brca1Rattranscription coactivator activity enablesISOBrca1 (Mus musculus)1624291 PMID:20820192RGDPMID:20820192
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RGD Manual Annotations


  

Imported Annotations - KEGG (archival)

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Original Reference(s)
Brca1Ratubiquitin/proteasome degradation pathway  IEA 6907045 KEGGrno:04120

Imported Annotations - PID (archival)

Object Symbol
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Original Reference(s)
Brca1Ratforkhead class A signaling pathway  ISOBRCA1 (Homo sapiens)6484113 PIDPID:200226

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#
Reference Title
Reference Citation
1. Retroviral transduction of splice variant Brca1-Delta11 or mutant Brca1-W1777Stop causes mouse epithelial mammary atypical duct hyperplasia. Bachelier R, etal., Virchows Arch. 2002 Mar;440(3):261-6. Epub 2001 Sep 22.
2. Transcriptional regulation by p53. Beckerman R and Prives C, Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a000935. doi: 10.1101/cshperspect.a000935. Epub 2010 Apr 28.
3. Sequence analysis of the rat Brca1 homolog and its promoter region. Bennett LM, etal., Mamm Genome 1999 Jan;10(1):19-25.
4. Localization of human BRCA1 and BRCA2 in non-inherited colorectal carcinomas and matched normal mucosas. Bernard-Gallon DJ, etal., Anticancer Res. 2001 May-Jun;21(3B):2011-20.
5. Prepubertal estradiol and genistein exposures up-regulate BRCA1 mRNA and reduce mammary tumorigenesis. Cabanes A, etal., Carcinogenesis. 2004 May;25(5):741-8. Epub 2004 Jan 16.
6. Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform. Cao L, etal., Genes Dev. 2003 Jan 15;17(2):201-13.
7. Allelic imbalance in BRCA1 and BRCA2 gene expression is associated with an increased breast cancer risk. Chen X, etal., Hum Mol Genet. 2008 May 1;17(9):1336-48. Epub 2008 Jan 19.
8. Phosphorylated BRCA1 is predominantly located in the nucleus and mitochondria. Coene ED, etal., Mol Biol Cell. 2005 Feb;16(2):997-1010. Epub 2004 Dec 9.
9. Prolactin blocks nuclear translocation of VDR by regulating its interaction with BRCA1 in osteosarcoma cells. Deng C, etal., Mol Endocrinol. 2009 Feb;23(2):226-36. doi: 10.1210/me.2008-0075. Epub 2008 Dec 12.
10. Low levels of BRCA1 protein expression predict a worse prognosis in stage I-II colon cancer. Du C, etal., Int J Biol Markers. 2021 Mar;36(1):47-53. doi: 10.1177/1724600820986572. Epub 2021 Feb 14.
11. Tumor-protective and tumor-promoting actions of dietary whey proteins in an N-methyl-N-nitrosourea model of rat mammary carcinogenesis. Eason RR, etal., Nutr Cancer. 2006;55(2):171-7.
12. Risks of cancer in BRCA1-mutation carriers. Breast Cancer Linkage Consortium. Ford D, etal., Lancet. 1994 Mar 19;343(8899):692-5.
13. Prevalent somatic BRCA1 mutations shape clinically relevant genomic patterns of nasopharyngeal carcinoma in Southeast Europe. Fountzilas G, etal., Int J Cancer. 2018 Jan 1;142(1):66-80. doi: 10.1002/ijc.31023. Epub 2017 Sep 30.
14. Correlation between BRCA1 expression and clinicopathological factors including brain metastases in patients with non-small-cell lung cancer. Gachechiladze M, etal., Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2013 Sep;157(3):227-32. doi: 10.5507/bp.2012.099. Epub 2012 Nov 1.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
17. Expression of DNA double-strand break repair proteins ATM and BRCA1 predicts survival in colorectal cancer. Grabsch H, etal., Clin Cancer Res. 2006 Mar 1;12(5):1494-500. doi: 10.1158/1078-0432.CCR-05-2105.
18. Methylation of breast cancer susceptibility gene 1 (BRCA1) predicts recurrence in patients with curatively resected stage I non-small cell lung cancer. Harada H, etal., Cancer. 2013 Feb 15;119(4):792-8. doi: 10.1002/cncr.27754. Epub 2013 Jan 18.
19. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Hayes JD and Dinkova-Kostova AT, Trends Biochem Sci. 2014 Apr;39(4):199-218. doi: 10.1016/j.tibs.2014.02.002. Epub 2014 Mar 16.
20. Growth retardation and tumour inhibition by BRCA1. Holt JT, etal., Nat Genet. 1996 Mar;12(3):298-302. doi: 10.1038/ng0396-298.
1 to 20 of 65 rows
PMID:8895509   PMID:8944023   PMID:9171368   PMID:9662397   PMID:9774970   PMID:10868478   PMID:11172592   PMID:11934988   PMID:12419249   PMID:12890688   PMID:12913077   PMID:14654789  
PMID:15123655   PMID:15254237   PMID:15265711   PMID:15965487   PMID:16288014   PMID:16326698   PMID:16331276   PMID:17349954   PMID:17505062   PMID:17525340   PMID:17525341   PMID:17525342  
PMID:17643121   PMID:17873885   PMID:18516675   PMID:18809582   PMID:19117993   PMID:19261748   PMID:19261749   PMID:20160719   PMID:20351172   PMID:20495005   PMID:20551173   PMID:20668305  
PMID:20820192   PMID:21102443   PMID:21282464   PMID:22186889   PMID:22549958   PMID:23039116   PMID:23271346   PMID:23415688   PMID:23855721   PMID:26490168   PMID:27494651   PMID:28585187  
PMID:29498408   PMID:29656893  



Brca1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,917,693 - 86,978,012 (-)NCBIGRCr8
mRatBN7.21086,417,441 - 86,477,762 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,418,000 - 86,477,304 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1091,454,623 - 91,513,795 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,930,035 - 90,990,102 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,323,338 - 86,383,395 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,394,821 - 89,455,093 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,394,803 - 89,454,681 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01089,192,653 - 89,252,760 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,513,630 - 90,572,676 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11090,527,999 - 90,587,046 (-)NCBI
Celera1085,140,052 - 85,200,670 (-)NCBICelera
Cytogenetic Map10q31NCBI
BRCA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381743,044,295 - 43,170,327 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1743,044,295 - 43,170,245 (-)EnsemblGRCh38hg38GRCh38
GRCh371741,196,312 - 41,322,344 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361738,449,840 - 38,530,994 (-)NCBINCBI36Build 36hg18NCBI36
Build 341738,449,843 - 38,530,934NCBI
Celera1737,853,171 - 37,934,354 (-)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1736,962,663 - 37,043,809 (-)NCBIHuRef
CHM1_11741,431,851 - 41,513,018 (-)NCBICHM1_1
T2T-CHM13v2.01743,902,857 - 44,029,084 (-)NCBIT2T-CHM13v2.0
Brca1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,379,587 - 101,442,808 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,379,590 - 101,442,781 (-)EnsemblGRCm39 Ensembl
GRCm3811101,488,761 - 101,551,955 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,488,764 - 101,551,955 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711101,350,078 - 101,413,269 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611101,304,854 - 101,365,210 (-)NCBIMGSCv36mm8
Celera11113,175,987 - 113,239,169 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1165.18NCBI
Brca1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,819,023 - 16,855,528 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,819,463 - 16,870,780 (-)NCBIChiLan1.0ChiLan1.0
BRCA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21921,865,798 - 21,957,438 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11723,755,123 - 23,836,219 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01714,197,946 - 14,279,064 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11714,429,601 - 14,506,815 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1714,428,526 - 14,506,815 (+)Ensemblpanpan1.1panPan2
BRCA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1919,958,941 - 20,025,494 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl919,958,391 - 20,025,494 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha919,422,566 - 19,486,083 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0920,677,057 - 20,743,989 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl920,677,128 - 20,743,989 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1919,464,421 - 19,527,988 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0919,730,981 - 19,794,752 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0919,833,116 - 19,896,786 (+)NCBIUU_Cfam_GSD_1.0
Brca1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560219,272,096 - 19,340,929 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493649017,735,444 - 17,801,456 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BRCA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1219,786,020 - 19,854,668 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11219,788,087 - 19,854,515 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,028,878 - 20,093,800 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BRCA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,162,827 - 63,243,928 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607733,932,799 - 34,042,352 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Brca1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,188,136 - 1,241,964 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247951,186,043 - 1,238,986 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Brca1
496 total Variants


Assembly: mRatBN7.2
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
10 86448802 86448803 A G snv WAG/RijCrl (2020) View more Information
10 86449538 86449539 C G snv European Variation Archive Release 4, European Variation Archive Release 6, M520/NRrrcMcwi (2019NG), ACI/EurMcwi (2019), BUF/N (2020), M520/NRrrcMcwi (2019), M520/N (2020), ACI/EurMcwi (2019NG), European Variation Archive Release 3, ACI/N (2020) View more Information


Assembly: Rnor_6.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
10 89426178 89426179 A G snv WAG/RijCrl (2020) View more Information
10 89426914 89426915 C G snv ACI/N (MCW), Buf/N (MCW), M520/N (MCW), ACI/EurMcwi (RGD), ACI/N (2020), BUF/N (2020), M520/NRrrcMcwi (2019), M520/N (2020), ACI/EurMcwi (MCW), ACI/EurMcwi (2019) View more Information

Predicted Target Of
Summary Value
Count of predictions:126
Count of miRNA genes:93
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000028109
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 77 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat

1 to 10 of 77 rows
D10Arb30  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,457,117 - 86,457,246 (+)MAPPERmRatBN7.2
Rnor_6.01089,434,505 - 89,434,633NCBIRnor6.0
Rnor_5.01089,232,320 - 89,232,448UniSTSRnor5.0
RGSC_v3.41090,552,493 - 90,552,622RGDRGSC3.4
RGSC_v3.41090,552,494 - 90,552,622UniSTSRGSC3.4
RGSC_v3.11090,566,863 - 90,566,992RGD
Celera1085,180,493 - 85,180,621UniSTS
Cytogenetic Map10q32.1UniSTS
D10Chm56  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81086,921,047 - 86,921,278 (+)Marker Load Pipeline
mRatBN7.21086,420,805 - 86,421,038 (+)MAPPERmRatBN7.2
Rnor_6.01089,398,186 - 89,398,416NCBIRnor6.0
Rnor_5.01089,196,018 - 89,196,248UniSTSRnor5.0
RGSC_v3.41090,515,968 - 90,516,198UniSTSRGSC3.4
Celera1085,143,640 - 85,143,870UniSTS
Cytogenetic Map10q32.1UniSTS


The following Strains have been annotated to Brca1
SD     SD-Brca1m1Uwm    


This gene Brca1 is modified in the following models/strains:
SD-Brca1m1Uwm     SD-Brca1em1Kyo    




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000028109   ⟹   ENSRNOP00000028109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,418,468 - 86,477,304 (-)Ensembl
Rnor_6.0 Ensembl1089,395,848 - 89,454,681 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000083111   ⟹   ENSRNOP00000072366
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,418,000 - 86,477,304 (-)Ensembl
Rnor_6.0 Ensembl1089,394,803 - 89,452,200 (-)Ensembl
RefSeq Acc Id: NM_012514   ⟹   NP_036646
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,917,693 - 86,977,581 (-)NCBI
mRatBN7.21086,417,451 - 86,477,331 (-)NCBI
Rnor_6.01089,395,848 - 89,454,681 (-)NCBI
Rnor_5.01089,192,653 - 89,252,760 (-)NCBI
RGSC_v3.41090,513,630 - 90,572,676 (-)RGD
Celera1085,140,052 - 85,200,670 (-)RGD
Sequence:
RefSeq Acc Id: XM_008768092   ⟹   XP_008766314
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,917,693 - 86,978,012 (-)NCBI
mRatBN7.21086,417,441 - 86,477,762 (-)NCBI
Rnor_6.01089,394,821 - 89,455,093 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039086541   ⟹   XP_038942469
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,917,693 - 86,978,012 (-)NCBI
mRatBN7.21086,417,441 - 86,477,762 (-)NCBI
RefSeq Acc Id: XM_039086542   ⟹   XP_038942470
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,924,977 - 86,978,012 (-)NCBI
mRatBN7.21086,424,640 - 86,477,762 (-)NCBI
RefSeq Acc Id: XM_063269583   ⟹   XP_063125653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,917,693 - 86,978,012 (-)NCBI
RefSeq Acc Id: NP_036646   ⟸   NM_012514
- UniProtKB: P97951 (UniProtKB/Swiss-Prot),   O54952 (UniProtKB/Swiss-Prot),   A6HJD2 (UniProtKB/TrEMBL),   G3V8S5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766314   ⟸   XM_008768092
- Peptide Label: isoform X1
- UniProtKB: P97951 (UniProtKB/Swiss-Prot),   O54952 (UniProtKB/Swiss-Prot),   A6HJD2 (UniProtKB/TrEMBL),   G3V8S5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028109   ⟸   ENSRNOT00000028109
Ensembl Acc Id: ENSRNOP00000072366   ⟸   ENSRNOT00000083111
RefSeq Acc Id: XP_038942469   ⟸   XM_039086541
- Peptide Label: isoform X1
- UniProtKB: P97951 (UniProtKB/Swiss-Prot),   O54952 (UniProtKB/Swiss-Prot),   A6HJD2 (UniProtKB/TrEMBL),   G3V8S5 (UniProtKB/TrEMBL)
BRCA1 serine-rich   BRCT   RING-type


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697764
Promoter ID:EPDNEW_R8289
Type:initiation region
Name:Brca1_1
Description:BRCA1, DNA repair associated
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01089,454,684 - 89,454,744EPDNEW


1 to 40 of 42 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-23168 BioCyc
Ensembl Genes ENSRNOG00000020701 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000028109 ENTREZGENE
  ENSRNOT00000161138 ENTREZGENE
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot
  3.40.50.10190 UniProtKB/Swiss-Prot
InterPro BRCA1 UniProtKB/Swiss-Prot
  BRCA1-associated UniProtKB/Swiss-Prot
  BRCA1_serine_dom UniProtKB/Swiss-Prot
  BRCT_dom UniProtKB/Swiss-Prot
  BRCT_dom_sf UniProtKB/Swiss-Prot
  Znf_C3HC4_RING-type UniProtKB/Swiss-Prot
  Znf_RING UniProtKB/Swiss-Prot
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot
  Znf_RING_CS UniProtKB/Swiss-Prot
KEGG Report rno:497672 UniProtKB/Swiss-Prot
NCBI Gene Brca1 ENTREZGENE
PANTHER BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN UniProtKB/Swiss-Prot
  PTHR13763 UniProtKB/Swiss-Prot
Pfam BRCT UniProtKB/Swiss-Prot
  BRCT_assoc UniProtKB/Swiss-Prot
  zf-C3HC4 UniProtKB/Swiss-Prot
PharmGKB BRCA1 RGD
PhenoGen Brca1 PhenoGen
PIRSF BRCA1 UniProtKB/Swiss-Prot
PRINTS BRSTCANCERI UniProtKB/Swiss-Prot
PROSITE BRCT UniProtKB/Swiss-Prot
  ZF_RING_1 UniProtKB/Swiss-Prot
  ZF_RING_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020701 RatGTEx
SMART BRCT UniProtKB/Swiss-Prot
  RING UniProtKB/Swiss-Prot
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot
  SSF52113 UniProtKB/Swiss-Prot
UniProt A0A0G2K2T3 ENTREZGENE, UniProtKB/TrEMBL
  A6HJD2 ENTREZGENE, UniProtKB/TrEMBL
  B0FT14_RAT UniProtKB/TrEMBL
  BRCA1_RAT UniProtKB/Swiss-Prot
  G3V8S5 ENTREZGENE, UniProtKB/TrEMBL
  O54952 ENTREZGENE
1 to 40 of 42 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-01 Brca1  BRCA1, DNA repair associated  Brca1  breast cancer 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-25 Brca1  breast cancer 1  Brca1  breast cancer 1, early onset  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-01-14 Brca1  breast cancer 1, early onset  Brca1  breast cancer 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Brca1  breast cancer 1      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_domains amino terminal RING-finger domain with high homology in rat mouse and human suggesting a conserved biological function 62417
gene_domains contains an amino terminal RING finger domain, two nuclear localization signals, two BRCT domains at the carboxy terminus and a highly acidic region 67955
gene_mutations_overexpression intron 6 contains a polymorphism of a pentanucleotide TTTTG repeat between the WKY and WF strains 67955
gene_other a pronounced peak in the ratio of nonsynonymous to synonymous substitutions between codon 200-300, suggests that purifying (negative) selection is acting on silent sites 68720