Bax (BCL2 associated X, apoptosis regulator) - Rat Genome Database

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Gene: Bax (BCL2 associated X, apoptosis regulator) Rattus norvegicus
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Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
RGD ID: 2192
Description: Enables BH domain binding activity; heat shock protein binding activity; and protein-folding chaperone binding activity. Involved in several processes, including mitochondrion organization; response to anesthetic; and response to ischemia. Located in several cellular components, including cytosol; mitochondrial outer membrane; and perinuclear region of cytoplasm. Used to study brain glioma; endometriosis; morphine dependence; and pre-malignant neoplasm. Biomarker of several diseases, including artery disease (multiple); brain disease (multiple); heart disease (multiple); lung disease (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; ataxia telangiectasia; colon adenocarcinoma; and colorectal cancer. Orthologous to human BAX (BCL2 associated X, apoptosis regulator); PARTICIPATES IN intrinsic apoptotic pathway; ceramide signaling pathway; syndecan signaling pathway; INTERACTS WITH (+)-catechin; (+)-pilocarpine; (+)-sesamin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: apoptosis regulator BAX; Bcl2-associated X protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Bax-ps2  
Allele / Splice: Bax_v1   Bax_v2  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,076,472 - 105,081,906 (-)NCBIGRCr8
mRatBN7.2195,940,001 - 95,945,407 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,938,808 - 95,945,368 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,325,431 - 101,330,837 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,798,107 - 109,803,513 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,088,504 - 103,093,910 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,451,801 - 101,457,207 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,451,802 - 101,457,207 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,530,747 - 102,536,153 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,933,023 - 95,938,176 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1196,011,133 - 96,016,287 (-)NCBI
Celera190,195,913 - 90,201,319 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
BaxRatabdominal obesity-metabolic syndrome 1 treatmentIEP 13792503 RGD 
BaxRatacute kidney failure treatmentIEP 10053672 RGD 
BaxRatAcute Lung Injury  IEP 10054109associated with EndotoxemiaRGD 
BaxRatacute myocardial infarction amelioratesIEP 267358468 RGD 
BaxRatAdrenal Insufficiency  IEP 6482719associated with Pancreatitis more ...RGD 
BaxRatAlzheimer's disease  IEP 10054047 RGD 
BaxRatAlzheimer's disease treatmentIEP 13782188 RGD 
BaxRatAlzheimer's disease treatmentIEP 13782186 RGD 
BaxRatAlzheimer's disease  IEP 2293073 RGD 
BaxRatAlzheimer's disease  ISOBAX (Homo sapiens)10054039 RGD 
BaxRatAlzheimer's disease treatmentIEP 10054049 RGD 
BaxRatamyotrophic lateral sclerosis treatmentISOBax (Mus musculus)13506803 RGD 
BaxRatamyotrophic lateral sclerosis severityISOBax (Mus musculus)13506800 RGD 
BaxRatamyotrophic lateral sclerosis treatmentISOBax (Mus musculus)13506797 RGD 
BaxRatamyotrophic lateral sclerosis severityISOBax (Mus musculus)13506805 RGD 
BaxRatamyotrophic lateral sclerosis disease_progressionISOBax (Mus musculus)13506907 RGD 
BaxRatanti-basement membrane glomerulonephritis  IEP 1579984mRNA and protein:increased expression:kidneyRGD 
BaxRatataxia telangiectasia susceptibilityISOBAX (Homo sapiens)14394817DNA:mutations:introns:IVS1146C>T and IVS3+14A>G(human)RGD 
BaxRatbrain glioma treatmentIEP 13792502 RGD 
BaxRatbrain glioma treatmentIDA 13792598 RGD 
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BaxRatcolon carcinoma  ISOBAX (Homo sapiens)8554872ClinVar Annotator: match by term: Carcinoma of colonClinVarPMID:10984511 more ...
BaxRatgenetic disease  ISOBAX (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:10984511 more ...
BaxRatT-cell acute lymphoblastic leukemia  ISOBAX (Homo sapiens)8554872ClinVar Annotator: match by term: T-cell acute lymphoblastic leukemiaClinVarPMID:9531611
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BaxRatacute kidney failure  ISOBAX (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20623750
BaxRatacute lymphoblastic leukemia  ISOBAX (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
BaxRatAlzheimer's disease  ISOBAX (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18077176
BaxRatBreast Neoplasms  ISOBAX (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:22572619
BaxRatCerebral Hemorrhage  ISOBAX (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12721362
BaxRatChemical and Drug Induced Liver Injury  ISOBAX (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17906064
BaxRatColonic Neoplasms  ISOBAX (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17404573
BaxRatColorectal Neoplasms  ISOBAX (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
BaxRatEsophageal Neoplasms  ISOBAX (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17634542
BaxRatExperimental Diabetes Mellitus  ISOBAX (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23090186
BaxRathuman immunodeficiency virus infectious disease  ISOBAX (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12878215
BaxRatIntestinal Neoplasms  ISOBAX (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12663524
BaxRatischemia  ISOBAX (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15172883
BaxRatmale infertility  ISOBAX (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24723216
BaxRatMicrosatellite Instability  ISOBAX (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25701956
BaxRatmyocardial infarction  ISOBAX (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20079142 and PMID:25450231
BaxRatMyocardial Reperfusion Injury  ISOBAX (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20026869
BaxRatNerve Degeneration  ISOBAX (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:20385067
BaxRatpolycystic ovary syndrome  ISOBAX (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21062263
BaxRatprimary cutaneous T-cell non-Hodgkin lymphoma  ISOBAX (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12754746
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Original Reference(s)
BaxRatacute lymphoblastic leukemia  ISOBAX (Homo sapiens)7240710 OMIM 
BaxRatcolorectal cancer  ISOBAX (Homo sapiens)7240710 OMIM 

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BaxRat(+)-(S)-ar-turmerone increases expressionISOBAX (Homo sapiens)6480464ar-turmerone results in increased expression of BAX mRNA and ar-turmerone results in increased expression of BAX proteinCTDPMID:19250610
BaxRat(+)-catechin multiple interactionsEXP 6480464Catechin analog inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX mRNA] more ...CTDPMID:18611398 and PMID:34027802
BaxRat(+)-catechin increases expressionISOBAX (Homo sapiens)6480464Catechin results in increased expression of BAX mRNA and Catechin results in increased expression of BAX proteinCTDPMID:23706674
BaxRat(+)-catechin multiple interactionsISOBAX (Homo sapiens)6480464Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of BAX mRNA]CTDPMID:21882252
BaxRat(+)-dexrazoxane multiple interactionsISOBax (Mus musculus)6480464[Doxorubicin co-treated with Dexrazoxane] results in decreased expression of BAX mRNA more ...CTDPMID:26873546 and PMID:28973540
BaxRat(+)-pilocarpine decreases expressionEXP 6480464Pilocarpine results in decreased expression of BAX mRNACTDPMID:17971868
BaxRat(+)-pilocarpine increases expressionEXP 6480464Pilocarpine results in increased expression of BAX mRNA and Pilocarpine results in increased expression of BAX proteinCTDPMID:14754538 more ...
BaxRat(+)-sesamin multiple interactionsISOBax (Mus musculus)6480464sesamin inhibits the reaction [nickel sulfate results in increased expression of BAX protein]CTDPMID:23317420
BaxRat(+)-sesamin multiple interactionsEXP 6480464sesamin affects the reaction [Glucose affects the expression of BAX protein]CTDPMID:22524206
BaxRat(+)-taxifolin multiple interactionsEXP 6480464Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of BAX protein]] more ...CTDPMID:35465754
BaxRat(+)-Tetrandrine increases expressionISOBAX (Homo sapiens)6480464tetrandrine results in increased expression of BAX proteinCTDPMID:26822499 and PMID:31255635
BaxRat(+)-trans-(S)-allethrin multiple interactionsISOBAX (Homo sapiens)6480464Vitamin E inhibits the reaction [bioallethrin results in increased expression of BAX protein]CTDPMID:35511042
BaxRat(+)-trans-(S)-allethrin increases expressionISOBAX (Homo sapiens)6480464bioallethrin results in increased expression of BAX proteinCTDPMID:35511042
BaxRat(-)-anisomycin multiple interactionsISOBax (Mus musculus)6480464Anisomycin promotes the reaction [triethylene glycol dimethacrylate results in increased expression of BAX protein]CTDPMID:33684387
BaxRat(-)-bornyl-caffeate increases expressionEXP 6480464bornyl caffeate results in increased expression of BAXCTDPMID:24907532
BaxRat(-)-citrinin increases expressionISOBax (Mus musculus)6480464Citrinin results in increased expression of BAX proteinCTDPMID:21622943
BaxRat(-)-citrinin affects expressionISOBax (Mus musculus)6480464Citrinin affects the expression of BAX proteinCTDPMID:22771370
BaxRat(-)-ephedrine increases expressionEXP 6480464Ephedrine results in increased expression of BAX proteinCTDPMID:32729338
BaxRat(-)-epigallocatechin 3-gallate multiple interactionsISOBAX (Homo sapiens)6480464[decitabine co-treated with epigallocatechin gallate] affects the expression of BAX mRNA more ...CTDPMID:12672908 more ...
BaxRat(-)-epigallocatechin 3-gallate increases expressionISOBax (Mus musculus)6480464epigallocatechin gallate results in increased expression of BAX proteinCTDPMID:34600025

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Biological Process
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Original Reference(s)
BaxRatapoptotic mitochondrial changes involved_inISSUniProtKB:Q078121600115GO_REF:0000024UniProtGO_REF:0000024
BaxRatapoptotic mitochondrial changes acts_upstream_of_or_withinIEAUniProtKB:Q07813 and ensembl:ENSMUSP000000330931600115GO_REF:0000107EnsemblGO_REF:0000107
BaxRatapoptotic mitochondrial changes acts_upstream_of_or_withinISOBax (Mus musculus)1624291 PMID:12925707RGDPMID:12925707
BaxRatapoptotic mitochondrial changes involved_inIEAUniProtKB:Q07812 and ensembl:ENSP000002632621600115GO_REF:0000107EnsemblGO_REF:0000107
BaxRatapoptotic mitochondrial changes involved_inISOBAX (Homo sapiens)1624291 PMID:9843949RGDPMID:9843949
BaxRatapoptotic process involved_inISOBAX (Homo sapiens)1624291 PMID:17428862 more ...RGDPMID:17428862 more ...
BaxRatapoptotic process acts_upstream_of_or_withinIEAUniProtKB:Q07813 and ensembl:ENSMUSP000000330931600115GO_REF:0000107EnsemblGO_REF:0000107
BaxRatapoptotic process involved_inIEAUniProtKB:Q07812 and ensembl:ENSP000002632621600115GO_REF:0000107EnsemblGO_REF:0000107
BaxRatapoptotic process acts_upstream_ofISOBax (Mus musculus)1624291MGI:1857429 more ...RGDPMID:15578100 more ...
BaxRatapoptotic process acts_upstream_of_or_withinISOBax (Mus musculus)1624291MGI:1857429 PMID:10201940 more ...RGDPMID:10201940 more ...
BaxRatapoptotic process involved_inIEAUniProtKB-KW:KW-00531600115GO_REF:0000043UniProtGO_REF:0000043
BaxRatapoptotic process involved in blood vessel morphogenesis acts_upstream_of_or_withinISOBax (Mus musculus)1624291MGI:1097161 PMID:15955981RGDPMID:15955981
BaxRatapoptotic process involved in blood vessel morphogenesis acts_upstream_of_or_withinIEAUniProtKB:Q07813 and ensembl:ENSMUSP000000330931600115GO_REF:0000107EnsemblGO_REF:0000107
BaxRatapoptotic process involved in embryonic digit morphogenesis acts_upstream_of_or_withinIEAUniProtKB:Q07813 and ensembl:ENSMUSP000000330931600115GO_REF:0000107EnsemblGO_REF:0000107
BaxRatapoptotic process involved in embryonic digit morphogenesis acts_upstream_of_or_withinISOBax (Mus musculus)1624291MGI:1197519 PMID:15967824RGDPMID:15967824
BaxRatapoptotic process involved in mammary gland involution acts_upstream_ofIEAUniProtKB:Q07813 and ensembl:ENSMUSP000000330931600115GO_REF:0000107EnsemblGO_REF:0000107
BaxRatapoptotic process involved in mammary gland involution acts_upstream_ofISOBax (Mus musculus)1624291MGI:1857429 PMID:10363969RGDPMID:10363969
BaxRatapoptotic signaling pathway involved_inISSUniProtKB:Q078121600115GO_REF:0000024UniProtGO_REF:0000024
BaxRatapoptotic signaling pathway involved_inIEAUniProtKB:Q07812 and ensembl:ENSP000002632621600115GO_REF:0000107EnsemblGO_REF:0000107
BaxRatapoptotic signaling pathway acts_upstream_ofISOBax (Mus musculus)1624291MGI:2675387 PMID:18436203RGDPMID:18436203
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Cellular Component
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BaxRatBAK complex part_ofISOBAX (Homo sapiens)1624291 PMID:16113678RGDPMID:16113678
BaxRatBAK complex part_ofIEAUniProtKB:Q07812 and ensembl:ENSP000002632621600115GO_REF:0000107EnsemblGO_REF:0000107
BaxRatBAX complex part_ofISSUniProtKB:Q078121600115GO_REF:0000024UniProtGO_REF:0000024
BaxRatBAX complex part_ofIEAUniProtKB:Q07812 and ensembl:ENSP000002632621600115GO_REF:0000107EnsemblGO_REF:0000107
BaxRatBAX complex part_ofIEAUniProtKB:Q07813 and ensembl:ENSMUSP000000330931600115GO_REF:0000107EnsemblGO_REF:0000107
BaxRatBAX complex part_ofISOBax (Mus musculus)1624291UniProtKB:Q07817 and PMID:11060313RGDPMID:11060313
BaxRatBAX complex part_ofISOBAX (Homo sapiens)1624291 PMID:14522999 more ...RGDPMID:14522999 more ...
BaxRatBcl-2 family protein complex part_ofISSUniProtKB:Q078121600115GO_REF:0000024UniProtGO_REF:0000024
BaxRatBcl-2 family protein complex part_ofIEAUniProtKB:Q07812 and ensembl:ENSP000002632621600115GO_REF:0000107EnsemblGO_REF:0000107
BaxRatBcl-2 family protein complex part_ofISOBAX (Homo sapiens)1624291 PMID:21199865RGDPMID:21199865
BaxRatcell periphery located_inISOBAX (Homo sapiens)1624291 PMID:21803450RGDPMID:21803450
BaxRatcell periphery located_inIEAUniProtKB:Q07812 and ensembl:ENSP000002632621600115GO_REF:0000107EnsemblGO_REF:0000107
BaxRatcytoplasm located_inISOBAX (Homo sapiens)1624291 PMID:16302269 and PMID:29531808RGDPMID:16302269 and PMID:29531808
BaxRatcytoplasm located_inIEAUniProtKB:Q07812 and ensembl:ENSP000002632621600115GO_REF:0000107EnsemblGO_REF:0000107
BaxRatcytoplasm located_inIEAUniProtKB:Q07813 and ensembl:ENSMUSP000000330931600115GO_REF:0000107EnsemblGO_REF:0000107
BaxRatcytoplasm located_inISOBax (Mus musculus)1624291 PMID:10464378 more ...RGDPMID:10464378 more ...
BaxRatcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
BaxRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
BaxRatcytoplasm  IDA 408395141MMO:0000538RGD 
BaxRatcytosol located_inISOBax (Mus musculus)1624291 PMID:11369777 more ...RGDPMID:11369777 more ...
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Molecular Function
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BaxRatBH domain binding  IPIMcl1 (Rattus norvegicus)70678 RGD 
BaxRatBH domain binding  IPIBcl2l2 (Rattus norvegicus)70678 RGD 
BaxRatBH domain binding  IPIBcl2l1 (Rattus norvegicus)70678 RGD 
BaxRatBH domain binding  IPIBcl2 (Rattus norvegicus)70678 RGD 
BaxRatBH domain binding  IPIBcl2a1 (Rattus norvegicus)70678 RGD 
BaxRatBH3 domain binding enablesISSUniProtKB:Q078121600115GO_REF:0000024UniProtGO_REF:0000024
BaxRatBH3 domain binding enablesIEAUniProtKB:Q07812 and ensembl:ENSP000002632621600115GO_REF:0000107EnsemblGO_REF:0000107
BaxRatBH3 domain binding enablesISOBAX (Homo sapiens)1624291UniProtKB:P55957 more ...RGDPMID:15705586 more ...
BaxRatchannel activity enablesISSUniProtKB:Q078121600115GO_REF:0000024UniProtGO_REF:0000024
BaxRatchannel activity enablesIEAUniProtKB:Q07812 and ensembl:ENSP000002632621600115GO_REF:0000107EnsemblGO_REF:0000107
BaxRatchannel activity enablesIBAPANTHER:PTN000135648 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
BaxRatchannel activity enablesISOBAX (Homo sapiens)1624291 PMID:9219694RGDPMID:9219694
BaxRatheat shock protein binding  IPIHspd1 (Rattus norvegicus)1581882 RGD 
BaxRatheat shock protein binding  IPIHspd1 (Rattus norvegicus)2298710 RGD 
BaxRatHsp70 protein binding enablesISOBax (Mus musculus)1624291 PMID:14752510RGDPMID:14752510
BaxRatHsp70 protein binding enablesIEAUniProtKB:Q07813 and ensembl:ENSMUSP000000330931600115GO_REF:0000107EnsemblGO_REF:0000107
BaxRatidentical protein binding enablesISOBax (Mus musculus)1624291PR:P10417 more ...RGDPMID:10582606 more ...
BaxRatidentical protein binding enablesIEAUniProtKB:Q07812 and ensembl:ENSP000002632621600115GO_REF:0000107EnsemblGO_REF:0000107
BaxRatidentical protein binding enablesIEAUniProtKB:Q07813 and ensembl:ENSMUSP000000330931600115GO_REF:0000107EnsemblGO_REF:0000107
BaxRatidentical protein binding enablesISOBax (Mus musculus) and PR:Q07813-11624291UniProtKB:Q07813-1 and PMID:26299946RGDPMID:26299946
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RGD Manual Annotations


  

Imported Annotations - KEGG (archival)

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BaxRatamyotrophic lateral sclerosis pathway  IEArno:050306907045 KEGGrno:05014
BaxRatapoptotic cell death pathway  IEA 6907045 KEGGrno:04210
BaxRatcolorectal cancer pathway   IEA 6907045 KEGGrno:05210
BaxRatEndoplasmic Reticulum-associated degradation pathway  IEA 6907045 KEGGrno:04141
BaxRatHuntington's disease pathway   IEA 6907045 KEGGrno:05016
BaxRatneurotrophic factor signaling pathway  IEA 6907045 KEGGrno:04722
BaxRatp53 signaling pathway   IEA 6907045 KEGGrno:04115
BaxRatprion disease pathway  IEA 6907045 KEGGrno:05020
BaxRattuberculosis pathway  IEA 6907045 KEGGrno:05152
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Imported Annotations - PID (archival)

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BaxRatceramide signaling pathway  ISOBAX (Homo sapiens)6484113 PIDPID:200119
BaxRatsyndecan signaling pathway  ISOBAX (Homo sapiens)6484113 PIDPID:200192

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Reference Title
Reference Citation
1. Bax interacts with the voltage-dependent anion channel and mediates ethanol-induced apoptosis in rat hepatocytes. Adachi M, etal., Am J Physiol Gastrointest Liver Physiol. 2004 Sep;287(3):G695-705. Epub 2004 Mar 25.
2. The Bcl-2 apoptotic switch in cancer development and therapy. Adams JM and Cory S, Oncogene. 2007 Feb 26;26(9):1324-37.
3. Bax mutation and overexpression inversely correlate with immature phenotype and prognosis of childhood germ cell tumors. Addeo R, etal., Oncol Rep. 2007 May;17(5):1155-61.
4. Lung injury after ischemia-reperfusion of small intestine in rats involves apoptosis of type II alveolar epithelial cells mediated by TNF-alpha and activation of Bid pathway. An S, etal., Apoptosis. 2007 Nov;12(11):1989-2001. doi: 10.1007/s10495-007-0125-1.
5. Neutrophil gelatinase-associated lipocalin (NGAL) may play a protective role against rats ischemia/reperfusion renal injury via inhibiting tubular epithelial cell apoptosis. An S, etal., Ren Fail. 2013;35(1):143-9. doi: 10.3109/0886022X.2012.741877. Epub 2012 Nov 15.
6. Bax and heart mitochondria: uncoupling and inhibition of respiration without permeability transition. Appaix F, etal., Biochim Biophys Acta 2002 Dec 2;1556(2-3):155-67.
7. Myocardial fibrosis and apoptosis, but not inflammation, are present in long-term experimental diabetes. Ares-Carrasco S, etal., Am J Physiol Heart Circ Physiol. 2009 Oct 9.
8. Elevated caspase and AIF gene expression correlate with progression of sarcopenia during aging in male F344BN rats. Baker DJ and Hepple RT, Exp Gerontol. 2006 Nov;41(11):1149-56. Epub 2006 Oct 6.
9. Cardioprotective role of growth/differentiation factor 1 in post-infarction left ventricular remodelling and dysfunction. Bao MW, etal., J Pathol. 2015 Jul;236(3):360-72. doi: 10.1002/path.4523. Epub 2015 Mar 30.
10. Bax and Bid act in synergy to bring about T11TS-mediated glioma apoptosis via the release of mitochondrial cytochrome c and subsequent caspase activation. Bhattacharjee M, etal., Int Immunol. 2008 Dec;20(12):1489-505. Epub 2008 Oct 17.
11. T11TS Treatment Augments Apoptosis of Glioma Associated Brain Endothelial Cells, Hint Toward Anti-Angiogenic Action in Glioma. Bhattacharya D, etal., J Cell Physiol. 2017 Mar;232(3):526-539. doi: 10.1002/jcp.25447. Epub 2016 Jun 21.
12. Differential profile of Nix upregulation and translocation during hypoxia/ischaemia in vivo versus in vitro. Birse-Archbold JL, etal., J Cereb Blood Flow Metab. 2005 Oct;25(10):1356-65.
13. Chemopreventive effect of a novel oleanane triterpenoid in a chemically induced rodent model of breast cancer. Bishayee A, etal., Int J Cancer. 2013 Sep 1;133(5):1054-63. doi: 10.1002/ijc.28108. Epub 2013 Mar 29.
14. ZFP36 protects lungs from intestinal I/R-induced injury and fibrosis through the CREBBP/p53/p21/Bax pathway. Cao Y, etal., Cell Death Dis. 2021 Jul 8;12(7):685. doi: 10.1038/s41419-021-03950-y.
15. Bax translocates to mitochondria of heart cells during simulated ischaemia: involvement of AMP-activated and p38 mitogen-activated protein kinases. Capano M and Crompton M, Biochem J. 2006 Apr 1;395(1):57-64.
16. Role of p97/Valosin-containing protein (VCP) and Jab1/CSN5 in testicular ischaemia-reperfusion injury. Cayli S, etal., J Mol Histol. 2016 Feb;47(1):91-100. doi: 10.1007/s10735-016-9652-9. Epub 2016 Jan 11.
17. Significance of Bcl-2 and Bax proteins in cervical carcinogenesis: an immunohistochemical study in squamous cell carcinoma and squamous intraepithelial lesions. Cheah PL and Looi LM, Malays J Pathol. 2006 Jun;28(1):1-5.
18. Induction of Bcl-2 and Bax was related to hyperphosphorylation of tau and neuronal death induced by okadaic acid in rat brain. Chen LQ, etal., Anat Rec A Discov Mol Cell Evol Biol. 2005 Dec;287(2):1236-45.
19. Interfering effect and mechanism of neuregulin on experimental dementia model in rats. Chen Y, etal., Behav Brain Res. 2011 Sep 23;222(2):321-5. doi: 10.1016/j.bbr.2011.03.063. Epub 2011 Apr 5.
20. Bax deletion prevents neuronal loss but not neurological symptoms in a transgenic model of inherited prion disease. Chiesa R, etal., Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):238-43. doi: 10.1073/pnas.0406173102. Epub 2004 Dec 23.
1 to 20 of 179 rows
1 to 10 of 30 rows
PMID:1558161   PMID:7650488   PMID:7828536   PMID:7834748   PMID:8358790   PMID:8625820   PMID:8631771   PMID:8798452   PMID:8816704   PMID:8918887   PMID:9008714   PMID:9056387  
PMID:9096145   PMID:9111042   PMID:9176392   PMID:9219694   PMID:9241272   PMID:9388232   PMID:9454845   PMID:9454852   PMID:9553144   PMID:9560217   PMID:9660918   PMID:9699561  
PMID:9843949   PMID:9988273   PMID:10201940   PMID:10363969   PMID:10464378   PMID:10479688   PMID:10486519   PMID:10597216   PMID:10618441   PMID:10620504   PMID:10639175   PMID:10683286  
PMID:10744634   PMID:10762311   PMID:10884318   PMID:10894153   PMID:10931486   PMID:10995754   PMID:11060313   PMID:11146002   PMID:11146504   PMID:11150333   PMID:11163212   PMID:11226327  
PMID:11350920   PMID:11369777   PMID:11413548   PMID:11604501   PMID:11717344   PMID:11784036   PMID:11836241   PMID:11864976   PMID:11906913   PMID:11912183   PMID:11980919   PMID:12009022  
PMID:12097139   PMID:12184852   PMID:12198774   PMID:12499352   PMID:12529375   PMID:12591359   PMID:12606450   PMID:12715101   PMID:12810599   PMID:12847083   PMID:12910269   PMID:12917363  
PMID:12925707   PMID:12925958   PMID:12943686   PMID:12952892   PMID:12959737   PMID:12967636   PMID:14502238   PMID:14507967   PMID:14517300   PMID:14517994   PMID:14522999   PMID:14561915  
PMID:14614769   PMID:14623868   PMID:14625274   PMID:14651853   PMID:14660547   PMID:14729675   PMID:14752510   PMID:14754538   PMID:14769861   PMID:14871028   PMID:14963330   PMID:15051517  
PMID:15102863   PMID:15138279   PMID:15214043   PMID:15219885   PMID:15304216   PMID:15309723   PMID:15342910   PMID:15351738   PMID:15356200   PMID:15469889   PMID:15499375   PMID:15525785  
PMID:15528359   PMID:15545017   PMID:15574493   PMID:15578100   PMID:15581613   PMID:15590655   PMID:15590937   PMID:15613488   PMID:15637643   PMID:15680329   PMID:15705586   PMID:15719136  
1 to 10 of 30 rows



Bax
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,076,472 - 105,081,906 (-)NCBIGRCr8
mRatBN7.2195,940,001 - 95,945,407 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,938,808 - 95,945,368 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,325,431 - 101,330,837 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,798,107 - 109,803,513 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,088,504 - 103,093,910 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,451,801 - 101,457,207 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,451,802 - 101,457,207 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,530,747 - 102,536,153 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,933,023 - 95,938,176 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1196,011,133 - 96,016,287 (-)NCBI
Celera190,195,913 - 90,201,319 (-)NCBICelera
Cytogenetic Map1q22NCBI
BAX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381948,954,875 - 48,961,798 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1948,954,815 - 48,961,798 (+)EnsemblGRCh38hg38GRCh38
GRCh371949,458,132 - 49,465,055 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,149,929 - 54,156,867 (+)NCBINCBI36Build 36hg18NCBI36
Build 341954,149,928 - 54,156,866NCBI
Celera1946,325,480 - 46,332,409 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,835,055 - 45,841,975 (+)NCBIHuRef
CHM1_11949,460,326 - 49,467,266 (+)NCBICHM1_1
T2T-CHM13v2.01951,949,757 - 51,956,683 (+)NCBIT2T-CHM13v2.0
Bax
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,111,124 - 45,116,332 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,111,121 - 45,116,322 (-)EnsemblGRCm39 Ensembl
GRCm38745,461,695 - 45,466,903 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,461,697 - 45,466,898 (-)EnsemblGRCm38mm10GRCm38
MGSCv37752,717,065 - 52,722,268 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36745,329,744 - 45,334,864 (-)NCBIMGSCv36mm8
Celera740,917,745 - 40,922,946 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.32NCBI
Bax
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,695,960 - 1,700,244 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555591,695,960 - 1,700,246 (-)NCBIChiLan1.0ChiLan1.0
BAX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22055,059,801 - 55,066,754 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11956,985,941 - 56,992,885 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01945,955,926 - 45,962,870 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11954,793,594 - 54,800,466 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1954,793,594 - 54,800,468 (-)Ensemblpanpan1.1panPan2
BAX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,423,388 - 107,426,464 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,422,424 - 107,426,464 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1106,945,329 - 106,949,006 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01107,947,413 - 107,951,165 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1107,947,430 - 107,951,107 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,614,952 - 107,618,629 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,261,311 - 107,264,988 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,096,913 - 108,100,590 (-)NCBIUU_Cfam_GSD_1.0
Bax
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,349,880 - 21,355,462 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366642,967,865 - 2,973,820 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366642,968,103 - 2,973,652 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BAX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,222,336 - 54,228,147 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1654,222,341 - 54,228,150 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,100,514 - 50,106,337 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BAX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,186,028 - 42,193,105 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607322,071,985 - 22,079,701 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bax
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248325,050,222 - 5,055,506 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248325,050,222 - 5,068,565 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Bax
12 total Variants

Predicted Target Of
Summary Value
Count of predictions:58
Count of miRNA genes:52
Interacting mature miRNAs:58
Transcripts:ENSRNOT00000028328
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 45 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat

1 to 10 of 45 rows
PMC114802P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2897,646,552 - 97,647,024 (+)MAPPERmRatBN7.2
mRatBN7.21086,532,320 - 86,532,859 (+)MAPPERmRatBN7.2
Rnor_6.01089,509,784 - 89,510,322NCBIRnor6.0
Rnor_6.08104,949,278 - 104,949,749NCBIRnor6.0
Rnor_5.01089,307,349 - 89,307,887UniSTSRnor5.0
Rnor_5.08104,395,475 - 104,395,946UniSTSRnor5.0
RGSC_v3.41090,628,148 - 90,628,686UniSTSRGSC3.4
RGSC_v3.48102,144,412 - 102,144,883UniSTSRGSC3.4
Celera897,086,649 - 97,087,120UniSTS
Celera1085,255,228 - 85,255,766UniSTS
Cytogenetic Map8q31UniSTS
Cytogenetic Map10q32.1UniSTS
Cytogenetic Map1q31.2UniSTS
PMC30226P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2897,646,629 - 97,646,985 (+)MAPPERmRatBN7.2
mRatBN7.21086,532,407 - 86,532,820 (+)MAPPERmRatBN7.2
Rnor_6.01089,509,871 - 89,510,283NCBIRnor6.0
Rnor_6.08104,949,355 - 104,949,710NCBIRnor6.0
Rnor_5.01089,307,436 - 89,307,848UniSTSRnor5.0
Rnor_5.08104,395,552 - 104,395,907UniSTSRnor5.0
RGSC_v3.41090,628,235 - 90,628,647UniSTSRGSC3.4
RGSC_v3.48102,144,489 - 102,144,844UniSTSRGSC3.4
Celera897,086,726 - 97,087,081UniSTS
Celera1085,255,315 - 85,255,727UniSTS
Cytogenetic Map8q31UniSTS
Cytogenetic Map10q32.1UniSTS
Cytogenetic Map1q31.2UniSTS
Bax  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,943,650 - 95,944,822 (+)MAPPERmRatBN7.2
Rnor_6.01101,455,451 - 101,456,622NCBIRnor6.0
Rnor_5.01102,534,397 - 102,535,568UniSTSRnor5.0
RGSC_v3.4195,936,509 - 95,937,680UniSTSRGSC3.4
Celera190,199,563 - 90,200,734UniSTS
Cytogenetic Map1q31.2UniSTS
GDB:632822  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,532,279 - 86,532,860 (+)MAPPERmRatBN7.2
Rnor_6.01089,509,743 - 89,510,323NCBIRnor6.0
Rnor_5.01089,307,308 - 89,307,888UniSTSRnor5.0
RGSC_v3.41090,628,107 - 90,628,687UniSTSRGSC3.4
Celera1085,255,187 - 85,255,767UniSTS
Cytogenetic Map10q32.1UniSTS
Cytogenetic Map1q31.2UniSTS
BARC0009  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2897,646,559 - 97,646,989 (+)MAPPERmRatBN7.2
Rnor_6.08104,949,285 - 104,949,714NCBIRnor6.0
Rnor_5.08104,395,482 - 104,395,911UniSTSRnor5.0
RGSC_v3.48102,144,419 - 102,144,848UniSTSRGSC3.4
Celera897,086,656 - 97,087,085UniSTS
Cytogenetic Map8q31UniSTS
Cytogenetic Map1q31.2UniSTS
Bax  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81105,080,120 - 105,081,061 (+)Marker Load Pipeline
mRatBN7.2195,943,649 - 95,944,590 (+)MAPPERmRatBN7.2
Rnor_6.01101,455,450 - 101,456,390NCBIRnor6.0
Rnor_5.01102,534,396 - 102,535,336UniSTSRnor5.0
RGSC_v3.4195,936,508 - 95,937,448UniSTSRGSC3.4
Celera190,199,562 - 90,200,502UniSTS
Cytogenetic Map1q31.2UniSTS
Bax  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,532,629 - 86,532,776 (+)MAPPERmRatBN7.2
Rnor_6.01089,510,093 - 89,510,239NCBIRnor6.0
Rnor_5.01089,307,658 - 89,307,804UniSTSRnor5.0
RGSC_v3.41090,628,457 - 90,628,603UniSTSRGSC3.4
Celera1085,255,537 - 85,255,683UniSTS
Cytogenetic Map10q32.1UniSTS
Cytogenetic Map1q31.2UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000028328   ⟹   ENSRNOP00000028328
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,938,808 - 95,945,368 (-)Ensembl
Rnor_6.0 Ensembl1101,451,802 - 101,457,207 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087061   ⟹   ENSRNOP00000075080
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1101,451,802 - 101,457,126 (-)Ensembl
RefSeq Acc Id: NM_017059   ⟹   NP_058755
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,076,472 - 105,081,878 (-)NCBI
mRatBN7.2195,940,001 - 95,945,407 (-)NCBI
Rnor_6.01101,451,801 - 101,457,207 (-)NCBI
Rnor_5.01102,530,747 - 102,536,153 (-)NCBI
RGSC_v3.4195,933,023 - 95,938,176 (-)RGD
Celera190,195,913 - 90,201,319 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063281064   ⟹   XP_063137134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,076,474 - 105,081,906 (-)NCBI
1 to 10 of 10 rows
Protein RefSeqs NP_058755 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137134 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA75200 (Get FASTA)   NCBI Sequence Viewer  
  AAC26327 (Get FASTA)   NCBI Sequence Viewer  
  AAC52998 (Get FASTA)   NCBI Sequence Viewer  
  AAC60700 (Get FASTA)   NCBI Sequence Viewer  
  AAF36411 (Get FASTA)   NCBI Sequence Viewer  
  EDM07348 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000028328
GenBank Protein Q63690 (Get FASTA)   NCBI Sequence Viewer  
1 to 10 of 10 rows
RefSeq Acc Id: NP_058755   ⟸   NM_017059
- UniProtKB: G3V8T9 (UniProtKB/TrEMBL),   A0A8I6GCB5 (UniProtKB/TrEMBL),   A6JB34 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075080   ⟸   ENSRNOT00000087061
Ensembl Acc Id: ENSRNOP00000028328   ⟸   ENSRNOT00000028328
RefSeq Acc Id: XP_063137134   ⟸   XM_063281064
- Peptide Label: isoform X1
Bcl-2 Bcl-2 homology region 1-3

Name Modeler Protein Id AA Range Protein Structure
AF-Q63690-F1-model_v2 AlphaFold Q63690 1-192 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690043
Promoter ID:EPDNEW_R565
Type:initiation region
Name:Bax_1
Description:BCL2 associated X, apoptosis regulator
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01101,457,158 - 101,457,218EPDNEW


1 to 34 of 34 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-59682 BioCyc
Ensembl Genes ENSRNOG00000020876 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000028328 ENTREZGENE
Gene3D-CATH 1.10.437.10 UniProtKB/Swiss-Prot
InterPro Bcl-2_BH1-3 UniProtKB/Swiss-Prot
  Bcl2-like UniProtKB/Swiss-Prot
  Bcl2_BH1_motif_CS UniProtKB/Swiss-Prot
  Bcl2_BH2_motif_CS UniProtKB/Swiss-Prot
  Bcl2_BH3_motif_CS UniProtKB/Swiss-Prot
  Blc2-like_sf UniProtKB/Swiss-Prot
  Blc2_fam UniProtKB/Swiss-Prot
NCBI Gene 24887 ENTREZGENE
PANTHER PTHR11256 UniProtKB/Swiss-Prot
  PTHR11256:SF42 UniProtKB/Swiss-Prot
Pfam Bcl-2 UniProtKB/Swiss-Prot
PharmGKB BAX RGD
PhenoGen Bax PhenoGen
PRINTS BCL2FAMILY UniProtKB/Swiss-Prot
PROSITE BCL2_FAMILY UniProtKB/Swiss-Prot
  BH1 UniProtKB/Swiss-Prot
  BH2 UniProtKB/Swiss-Prot
  BH3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020749 RatGTEx
  ENSRNOG00000020876 RatGTEx
SMART BCL UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56854 UniProtKB/Swiss-Prot
UniProt A0A8I6GCB5 ENTREZGENE, UniProtKB/TrEMBL
  A6JB34 ENTREZGENE, UniProtKB/TrEMBL
  BAX_RAT UniProtKB/Swiss-Prot
  G3V8T9 ENTREZGENE, UniProtKB/TrEMBL
  Q63690 ENTREZGENE
  Q9JKL3_RAT UniProtKB/TrEMBL
UniProt Secondary Q62995 UniProtKB/Swiss-Prot
  Q64383 UniProtKB/Swiss-Prot
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Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-22 Bax  BCL2 associated X, apoptosis regulator  Bax  Bcl2-associated X protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Bax  bcl2-associated X protein      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_cellular_localization mainly distributed in cytosol but translocating to the outer membrane during apoptosis signaling 70241
gene_cellular_localization level in mitochondria is unchanged with age 70304
gene_process Bax/Bax homodimers induce pores in the outer membrane and enhance apoptosis by mediating the release of cytochrome c 70303
gene_process required for the cell death of cerebellar granule neurons mediated by Dp5 and other BH-3 only proteins 70303
gene_process produces large pores in the outer membrane, inhibits some segments of the respiratory chain in the inner membrane and uncouples the inner mitochondrial membrane by increasing proton leak without opening the permeability transition pore (PTP) 628373
gene_process permeabilizes the outer mitochondrial membrane and triggers the release of cytochrome c and reduces the respiration rate 628373