Akt1 (AKT serine/threonine kinase 1) - Rat Genome Database

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Gene: Akt1 (AKT serine/threonine kinase 1) Rattus norvegicus
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Symbol: Akt1
Name: AKT serine/threonine kinase 1
RGD ID: 2081
Description: Enables several functions, including ATP binding activity; GTPase activating protein binding activity; and enzyme binding activity. Involved in several processes, including cellular hyperosmotic salinity response; protein phosphorylation; and regulation of protein metabolic process. Acts upstream of or within several processes, including negative regulation of cell size; positive regulation of sodium ion transport; and regulation of protein localization. Located in cytosol; dendrite; and nucleus. Used to study artery disease (multiple); autosomal recessive polycystic kidney disease; heroin dependence; impotence; and type 2 diabetes mellitus. Biomarker of several diseases, including brain ischemia; liver disease (multiple); opiate dependence; type 2 diabetes mellitus; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome 6; breast cancer (multiple); gastrointestinal system cancer (multiple); pancreatic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human AKT1 (AKT serine/threonine kinase 1); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; adenosine signaling pathway; INTERACTS WITH (+)-catechin; (+)-pilocarpine; (+)-taxifolin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Akt; AKT1 kinase; Murine thymoma viral (v-akt) oncogene homolog 1; PKB; PKB alpha; protein kinase B; protein kinase B alpha; RAC protein kinase alpha RAC-PK alpha; RAC protein kinase alpha, RAC-PK alpha; RAC-alpha serine/threonine-protein kinase; RAC-PK-alpha; thymoma viral proto-oncogene; thymoma viral proto-oncogene 1; v-akt murine thymoma viral oncogene homolog 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Akt1em1Soar  
Genetic Models: SD-Akt1em1Soar
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86137,534,810 - 137,555,131 (-)NCBIGRCr8
mRatBN7.26131,713,716 - 131,735,319 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6131,713,720 - 131,733,921 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6131,883,770 - 131,900,905 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06132,180,876 - 132,197,963 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06131,543,341 - 131,560,403 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06137,218,398 - 137,239,970 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6137,218,376 - 137,236,258 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06146,225,955 - 146,247,008 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46137,640,482 - 137,657,552 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16137,646,668 - 137,663,739 (-)NCBI
Celera6129,262,032 - 129,279,096 (-)NCBICelera
RH 3.4 Map6782.49RGD
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Akt1RatAcute Lung Injury severityISOAkt1 (Mus musculus)38676478 RGD 
Akt1Ratalcoholic hepatitis  ISOAKT1 (Homo sapiens)407987426protein:increased expression:liverRGD 
Akt1RatAlcoholic Liver Diseases treatmentISOAkt1 (Mus musculus)408345226 RGD 
Akt1RatAlzheimer's disease  ISOAkt1 (Mus musculus)5509085protein:increased tyrosine phosphorylation:cerebral cortexRGD 
Akt1Ratamphetamine abuse no_associationISOAKT1 (Homo sapiens)407419880DNA:SNPs:introns: (rs2494743 and 2498794)RGD 
Akt1Ratamphetamine abuse susceptibilityISOAKT1 (Homo sapiens)407419878DNA:SNP:intron: (rs3730358)RGD 
Akt1Ratamyotrophic lateral sclerosis  ISOAkt1 (Mus musculus)5509081protein:increased expression:skeletal muscleRGD 
Akt1Ratatherosclerosis severityISOAkt1 (Mus musculus)5509083 RGD 
Akt1Ratautosomal recessive polycystic kidney disease  IDA 10040950protein:increased serine phosphorylation:cholangiocyteRGD 
Akt1Ratbipolar disorder  ISOAKT1 (Homo sapiens)5509071DNA:SNP and haplotype: :multiple (human)RGD 
Akt1RatBrain Injuries  IEP 5509090protein:increased phosphorylation:brain and neuronRGD 
Akt1Ratbrain ischemia  IEP 5509066protein:decreased serine phosphorylation:cerebral cortexRGD 
Akt1RatBreast Neoplasms  ISOAKT1 (Homo sapiens)1643330protein:increased serine phosphorylation:breastRGD 
Akt1RatBreast Neoplasms susceptibilityISOAKT1 (Homo sapiens)1643334DNA:point mutation:cds:p.E17K (human)RGD 
Akt1RatBreast Neoplasms  ISOAKT1 (Homo sapiens)2313763 RGD 
Akt1Ratcardiac arrest  ISOAkt1 (Mus musculus)5509101 RGD 
Akt1RatCardiomegaly  ISOAkt1 (Mus musculus)734544 RGD 
Akt1Ratchronic myeloid leukemia  ISOAKT1 (Homo sapiens)13674160protein:increased phosphorylation:bloodRGD 
Akt1Ratcolon cancer treatmentIEP 127229954 RGD 
Akt1Ratcolon cancer severityISOAKT1 (Homo sapiens)152995462mRNA:increased expression:colon (human)RGD 
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Akt1Ratbreast adenocarcinoma  ISOAKT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Breast adenocarcinomaClinVarPMID:17611497 more ...
Akt1Ratbreast cancer  ISOAKT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Breast cancer and somaticClinVarPMID:17611497 more ...
Akt1Ratbreast cancer  ISOAKT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Malignant tumor of breastClinVarPMID:17611497 more ...
Akt1RatBreast Cancer, Familial  ISOAKT1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:17576681 more ...
Akt1RatBreast Neoplasms  ISOAKT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Breast NeoplasmsClinVarPMID:17611497 more ...
Akt1RatCharcot-Marie-Tooth disease axonal type 2O  ISOAKT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Charcot-Marie-Tooth disease axonal type 2OClinVarPMID:28492532
Akt1Ratcolon carcinoma  ISOAKT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Carcinoma of colonClinVarPMID:17611497 more ...
Akt1Ratcolorectal cancer  ISOAKT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Malignant Colorectal NeoplasmClinVarPMID:17576681 more ...
Akt1RatCowden syndrome 6  ISOAKT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Cowden syndrome 6ClinVarPMID:16199547 more ...
Akt1Ratfocal segmental glomerulosclerosis 5  ISOAKT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Focal segmental glomerulosclerosis 5ClinVarPMID:28492532
Akt1Ratgenetic disease  ISOAKT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
Akt1RatHereditary Neoplastic Syndromes  ISOAKT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary cancer-predisposing syndromeClinVarPMID:24728327 more ...
Akt1Ratimmunodeficiency 132A  ISOAKT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Herpes simplex encephalitis more ...ClinVarPMID:28492532
Akt1RatMacrocephaly Mesodermal Hamartoma Spectrum  ISOAKT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Macrocephaly mesodermal hamartoma spectrumClinVarPMID:17576681 more ...
Akt1Ratovarian cancer  ISOAKT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Ovarian cancerClinVarPMID:17576681 more ...
Akt1RatOvarian Neoplasms  ISOAKT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Ovarian neoplasmClinVarPMID:17611497 more ...
Akt1RatProteus syndrome  ISOAKT1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:17576681 more ...
Akt1Ratschizophrenia  ISOAKT1 (Homo sapiens)8554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:25741868 and PMID:28492532
Akt1Ratsquamous cell carcinoma  ISOAKT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Squamous cell carcinomaClinVarPMID:27993330
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Akt1Ratacute promyelocytic leukemia  ISOAKT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12556562
Akt1Ratadenocarcinoma  ISOAKT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:33129824
Akt1Ratamphetamine abuse  ISOAKT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15982448
Akt1RatAnimal Disease Models  ISOAKT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25658812 and PMID:32045588
Akt1RatBreast Neoplasms  ISOAKT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20228224
Akt1RatCalcification of Aortic Valve  ISOAKT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23308213
Akt1Ratcannabis abuse  ISOAKT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21041608
Akt1RatCarcinogenesis  ISOAKT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:32045588
Akt1RatCardiomegaly  ISOAKT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24448315
Akt1Ratcardiomyopathy  ISOAKT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24448315
Akt1RatColorectal Neoplasms  ISOAKT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Akt1Ratepilepsy  ISOAKT1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:20064661
Akt1Ratfamilial adenomatous polyposis  ISOAKT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17942926
Akt1RatFibrosis  ISOAKT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24448315
Akt1Rathead and neck squamous cell carcinoma  ISOAKT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23873848
Akt1Rathepatocellular carcinoma  ISOAKT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:32045588
Akt1RatHepatomegaly  ISOAKT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:32045588
Akt1RatHyperplasia  ISOAKT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20530298
Akt1RatHypertriglyceridemia  ISOAKT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:32045588
Akt1RatInflammation  ISOAKT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24448315 and PMID:26297436
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Akt1RatProteus syndrome  ISSAkt1 (Mus musculus)13592920OMIM:176920MouseDO 
Akt1Ratschizophrenia  ISSAkt1 (Mus musculus)13592920OMIM:181500MouseDO 

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Akt1Rat(+)-beta-thujone multiple interactionsISOAKT1 (Homo sapiens)6480464[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of AKT1 mRNACTDPMID:38000518
Akt1Rat(+)-catechin multiple interactionsISOAkt1 (Mus musculus)6480464[Quercetin co-treated with Catechin] results in increased phosphorylation of AKT1 proteinCTDPMID:26363153
Akt1Rat(+)-catechin decreases expressionISOAKT1 (Homo sapiens)6480464Catechin results in decreased expression of AKT1 mRNACTDPMID:39009138
Akt1Rat(+)-catechin increases phosphorylationEXP 6480464Catechin results in increased phosphorylation of AKT1 proteinCTDPMID:29981789
Akt1Rat(+)-catechin multiple interactionsEXP 6480464[Catechin co-treated with Glucose] results in increased phosphorylation of AKT1 protein and Catechin inhibits the reaction [Peroxynitrous Acid results in increased phosphorylation of AKT1 protein]CTDPMID:17302912 and PMID:29981789
Akt1Rat(+)-catechin decreases phosphorylationEXP 6480464Catechin results in decreased phosphorylation of AKT1 proteinCTDPMID:17302912
Akt1Rat(+)-catechin decreases phosphorylationISOAKT1 (Homo sapiens)6480464Catechin analog results in decreased phosphorylation of AKT1 protein and Catechin results in decreased phosphorylation of AKT1 proteinCTDPMID:16413414 and PMID:39009138
Akt1Rat(+)-catechin increases phosphorylationISOAkt1 (Mus musculus)6480464Catechin results in increased phosphorylation of AKT1 proteinCTDPMID:26363153
Akt1Rat(+)-epicatechin-3-O-gallate decreases phosphorylationISOAKT1 (Homo sapiens)6480464epicatechin gallate results in decreased phosphorylation of AKT1 proteinCTDPMID:21945981
Akt1Rat(+)-epicatechin-3-O-gallate multiple interactionsISOAKT1 (Homo sapiens)64804642-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]] more ...CTDPMID:29061316
Akt1Rat(+)-Eudesmin decreases phosphorylationISOAKT1 (Homo sapiens)6480464eudesmin results in decreased phosphorylation of AKT1 proteinCTDPMID:31026422
Akt1Rat(+)-pilocarpine decreases phosphorylationEXP 6480464Pilocarpine results in decreased phosphorylation of AKT1 proteinCTDPMID:19429016 and PMID:30542433
Akt1Rat(+)-pilocarpine multiple interactionsEXP 64804641 more ...CTDPMID:30542433 and PMID:31018114
Akt1Rat(+)-taxifolin multiple interactionsEXP 6480464Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]] more ...CTDPMID:32828744 and PMID:35465754
Akt1Rat(+)-Tetrandrine increases phosphorylationISOAKT1 (Homo sapiens)6480464tetrandrine results in increased phosphorylation of AKT1 proteinCTDPMID:31255635
Akt1Rat(+)-Tetrandrine decreases phosphorylationISOAKT1 (Homo sapiens)6480464tetrandrine results in decreased phosphorylation of AKT1 proteinCTDPMID:30549224
Akt1Rat(-)-alpha-phellandrene decreases expressionISOAKT1 (Homo sapiens)6480464alpha phellandrene results in decreased expression of AKT1 proteinCTDPMID:25649747
Akt1Rat(-)-Arctigenin multiple interactionsISOAKT1 (Homo sapiens)6480464[Quercetin co-treated with arctigenin] results in decreased expression of AKT1 protein more ...CTDPMID:25380086
Akt1Rat(-)-cotinine multiple interactionsISOAKT1 (Homo sapiens)64804642-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cotinine results in increased phosphorylation of AKT1 protein]CTDPMID:22687995
Akt1Rat(-)-cotinine increases phosphorylationISOAKT1 (Homo sapiens)6480464Cotinine results in increased phosphorylation of AKT1 proteinCTDPMID:22687995

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Biological Process
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Akt1Ratactivation-induced cell death of T cells acts_upstream_of_or_withinISOAKT1 (Homo sapiens)1624291 PMID:14749367RGDPMID:14749367
Akt1Ratactivation-induced cell death of T cells acts_upstream_of_or_withinIEAUniProtKB:P31749 and ensembl:ENSP000004978221600115GO_REF:0000107EnsemblGO_REF:0000107
Akt1Ratapoptotic mitochondrial changes acts_upstream_of_or_withinISOAkt1 (Mus musculus)1624291 PMID:12869584RGDPMID:12869584
Akt1Ratapoptotic mitochondrial changes acts_upstream_of_or_withinIEAUniProtKB:P31750 and ensembl:ENSMUSP000000017801600115GO_REF:0000107EnsemblGO_REF:0000107
Akt1Ratapoptotic process involved_inIEAUniProtKB-KW:KW-00531600115GO_REF:0000043UniProtGO_REF:0000043
Akt1Ratbehavioral response to pain involved_inIEAUniProtKB:P31750 and ensembl:ENSMUSP000000017801600115GO_REF:0000107EnsemblGO_REF:0000107
Akt1Ratbehavioral response to pain involved_inISOAkt1 (Mus musculus)1624291MGI:1914047 more ...RGDPMID:31874168
Akt1Ratcell migration involved in sprouting angiogenesis involved_inIEAUniProtKB:P31749 and ensembl:ENSP000004978221600115GO_REF:0000107EnsemblGO_REF:0000107
Akt1Ratcell migration involved in sprouting angiogenesis involved_inISOAKT1 (Homo sapiens)1624291 PMID:28341552RGDPMID:28341552
Akt1Ratcell projection organization acts_upstream_of_or_withinIDA 8554187PMID:16286931MGI 
Akt1Ratcellular hyperosmotic salinity response  IDA 408364951 RGD 
Akt1Ratcellular response to decreased oxygen levels acts_upstream_of_or_withinISOAkt1 (Mus musculus)1624291 PMID:24875179RGDPMID:24875179
Akt1Ratcellular response to decreased oxygen levels acts_upstream_of_or_withinIEAUniProtKB:P31750 and ensembl:ENSMUSP000000017801600115GO_REF:0000107EnsemblGO_REF:0000107
Akt1Ratcellular response to epidermal growth factor stimulus involved_inISOAkt1 (Mus musculus)1624291 PMID:21712384RGDPMID:21712384
Akt1Ratcellular response to epidermal growth factor stimulus  IDA 408345253 RGD 
Akt1Ratcellular response to epidermal growth factor stimulus involved_inISSUniProtKB:P317491600115GO_REF:0000024UniProtGO_REF:0000024
Akt1Ratcellular response to epidermal growth factor stimulus involved_inIEAUniProtKB:P31749 and ensembl:ENSP000004978221600115GO_REF:0000107EnsemblGO_REF:0000107
Akt1Ratcellular response to epidermal growth factor stimulus involved_inISOAKT1 (Homo sapiens)1624291 PMID:30514904RGDPMID:30514904
Akt1Ratcellular response to epidermal growth factor stimulus involved_inIEAUniProtKB:P31750 and ensembl:ENSMUSP000000017801600115GO_REF:0000107EnsemblGO_REF:0000107
Akt1Ratcellular response to granulocyte macrophage colony-stimulating factor stimulus acts_upstream_of_or_withinIEAUniProtKB:P31750 and ensembl:ENSMUSP000000017801600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Akt1Ratcell-cell junction located_inIEAUniProtKB:P31750 and ensembl:ENSMUSP000000017801600115GO_REF:0000107EnsemblGO_REF:0000107
Akt1Ratcell-cell junction located_inISOAkt1 (Mus musculus)1624291 PMID:23793062RGDPMID:23793062
Akt1Ratciliary basal body located_inIEAUniProtKB:P31750 and ensembl:ENSMUSP000000017801600115GO_REF:0000107EnsemblGO_REF:0000107
Akt1Ratciliary basal body located_inISOAkt1 (Mus musculus)1624291 PMID:19596798RGDPMID:19596798
Akt1Ratciliary basal body located_inIEAUniProtKB:B0LPE5 and ensembl:ENSP000004978221600115GO_REF:0000107EnsemblGO_REF:0000107
Akt1Ratciliary basal body located_inISOAKT1 (Homo sapiens) and UniProtKB:P31749-11624291 RGDGO_REF:0000052
Akt1Ratciliary basal body located_inIEAUniProtKB:P31749 and ensembl:ENSP000004978221600115GO_REF:0000107EnsemblGO_REF:0000107
Akt1Ratcilium located_inIEAUniProtKB:P31749 and ensembl:ENSP000004978221600115GO_REF:0000107EnsemblGO_REF:0000107
Akt1Ratcilium located_inIEAUniProtKB:B0LPE5 and ensembl:ENSP000004978221600115GO_REF:0000107EnsemblGO_REF:0000107
Akt1Ratcilium located_inISOAKT1 (Homo sapiens) and UniProtKB:P31749-11624291 RGDGO_REF:0000052
Akt1Ratcytoplasm located_inISOAKT1 (Sus scrofa)1624291 PMID:24508636RGDPMID:24508636
Akt1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Akt1Ratcytoplasm located_inIEAUniProtKB:P31749 and ensembl:ENSP000004978221600115GO_REF:0000107EnsemblGO_REF:0000107
Akt1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Akt1Ratcytoplasm located_inISOAkt1 (Mus musculus)1624291 PMID:12124386 more ...RGDPMID:12124386 more ...
Akt1Ratcytoplasm located_inISOAKT1 (Homo sapiens)1624291 PMID:19203586 and PMID:25190803RGDPMID:19203586 and PMID:25190803
Akt1Ratcytoplasm located_inIEAUniProtKB:P31750 and ensembl:ENSMUSP000000017801600115GO_REF:0000107EnsemblGO_REF:0000107
Akt1Ratcytoplasm is_active_inISOAKT1 (Homo sapiens)1624291 PMID:26440888RGDPMID:26440888
Akt1Ratcytosol  IDA 408345243 RGD 
Akt1Ratcytosol located_inISOAkt1 (Mus musculus)1624291 PMID:28930673RGDPMID:28930673
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Molecular Function
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Akt1Rat14-3-3 protein binding enablesIEAUniProtKB:P31749 and ensembl:ENSP000004978221600115GO_REF:0000107EnsemblGO_REF:0000107
Akt1Rat14-3-3 protein binding enablesISOAKT1 (Homo sapiens)1624291UniProtKB:P63104 and PMID:10102273RGDPMID:10102273
Akt1RatATP binding  IDA 2306431 RGD 
Akt1RatATP binding enablesIEAInterPro:IPR000719 and InterPro:IPR0174411600115GO_REF:0000002InterProGO_REF:0000002
Akt1RatATP binding enablesIEAInterPro:IPR000719 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Akt1RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Akt1RatATP binding enablesIEAUniProtKB:P31749 and ensembl:ENSP000004978221600115GO_REF:0000107EnsemblGO_REF:0000107
Akt1RatATP binding enablesISOAKT1 (Homo sapiens)1624291 PMID:16540465RGDPMID:16540465
Akt1RatATP binding enablesIEAUniRule:UR0015033411600115GO_REF:0000104UniProtGO_REF:0000104
Akt1Ratcalmodulin binding enablesISOAKT1 (Homo sapiens)1624291 PMID:29104511RGDPMID:29104511
Akt1Ratcalmodulin binding enablesIEAUniProtKB:P31749 and ensembl:ENSP000004978221600115GO_REF:0000107EnsemblGO_REF:0000107
Akt1Ratcalmodulin binding enablesISSUniProtKB:P317491600115GO_REF:0000024UniProtGO_REF:0000024
Akt1Ratenzyme binding enablesIPIUniProtKB:Q614098553650PMID:10454575BHF-UCL 
Akt1RatGTPase activating protein binding  IPIRasa1 (Rattus norvegicus)9999423 RGD 
Akt1Ratidentical protein binding enablesISOAKT1 (Homo sapiens)1624291UniProtKB:P31749 more ...RGDPMID:17554339 and PMID:7891724
Akt1Ratidentical protein binding enablesIEAUniProtKB:P31749 and ensembl:ENSP000004978221600115GO_REF:0000107EnsemblGO_REF:0000107
Akt1Ratkinase activity enablesISOAKT1 (Homo sapiens)1624291 PMID:14749367RGDPMID:14749367
Akt1Ratkinase activity enablesIEAUniProtKB:P31749 and ensembl:ENSP000004978221600115GO_REF:0000107EnsemblGO_REF:0000107
Akt1Ratkinase activity enablesISOAkt1 (Mus musculus)1624291 PMID:23886629RGDPMID:23886629
Akt1Ratkinase activity enablesIEAUniProtKB:P31750 and ensembl:ENSMUSP000000017801600115GO_REF:0000107EnsemblGO_REF:0000107
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Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

1 to 20 of 32 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Akt1Ratacute myeloid leukemia pathway  IEA 6907045 KEGGrno:05221
Akt1Ratapoptotic cell death pathway  IEA 6907045 KEGGrno:04210
Akt1RatB cell receptor signaling pathway  IEA 6907045 KEGGrno:04662
Akt1Ratceramide signaling pathway  IEA 6907045 KEGGrno:05212
Akt1RatChagas disease pathway  IEA 6907045 KEGGrno:05142
Akt1Ratchemokine mediated signaling pathway  IEA 6907045 KEGGrno:04062
Akt1Ratchronic myeloid leukemia pathway  IEA 6907045 KEGGrno:05220
Akt1Ratcolorectal cancer pathway   IEA 6907045 KEGGrno:05210
Akt1Ratendometrial cancer pathway   IEA 6907045 KEGGrno:05213
Akt1Ratepidermal growth factor/neuregulin signaling pathway   IEA 6907045 KEGGrno:04012
Akt1RatFc epsilon receptor mediated signaling pathway  IEA 6907045 KEGGrno:04664
Akt1RatFc gamma receptor mediated signaling pathway  IEA 6907045 KEGGrno:04666
Akt1Ratglioma pathway  IEA 6907045 KEGGrno:05214
Akt1Rathepatitis C pathway  IEA 6907045 KEGGrno:05160
Akt1Ratinfluenza A pathway  IEA 6907045 KEGGrno:05164
Akt1Ratinsulin signaling pathway   IEA 6907045 KEGGrno:04910
Akt1RatJak-Stat signaling pathway   IEA 6907045 KEGGrno:04630
Akt1Ratmeasles pathway  IEA 6907045 KEGGrno:05162
Akt1Ratmelanoma pathway  IEA 6907045 KEGGrno:05218
Akt1Ratmitogen activated protein kinase signaling pathway   IEA 6907045 KEGGrno:04010
1 to 20 of 32 rows

Imported Annotations - PID (archival)

1 to 20 of 23 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Akt1Ratceramide signaling pathway  ISOAKT1 (Homo sapiens)6484113 PIDPID:200119
Akt1RatE-cadherin signaling pathway  ISOAKT1 (Homo sapiens)6484113 PIDPID:200124
Akt1RatE-cadherin signaling pathway  ISOAKT1 (Homo sapiens)6484113 PIDPID:200147
Akt1Rateicosanoid signaling pathway  ISOAKT1 (Homo sapiens)6484113 PIDPID:200082
Akt1Ratendothelin signaling pathway  ISOAKT1 (Homo sapiens)6484113 PIDPID:200005
Akt1RatFasL mediated signaling pathway   ISOAKT1 (Homo sapiens)6484113 PIDPID:200080
Akt1Ratfibroblast growth factor signaling pathway  ISOAKT1 (Homo sapiens)6484113 PIDPID:200220
Akt1Ratforkhead class A signaling pathway  ISOAKT1 (Homo sapiens)6484113 PIDPID:200087
Akt1RatHedgehog signaling pathway   ISOAKT1 (Homo sapiens)6484113 PIDPID:200168
Akt1RatHedgehog signaling pathway   ISOAKT1 (Homo sapiens)6484113 PIDPID:200172
Akt1Rathypoxia inducible factor pathway   ISOAKT1 (Homo sapiens)6484113 PIDPID:200202
Akt1Ratinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOAKT1 (Homo sapiens)6484113 PIDPID:200196
Akt1Ratinsulin signaling pathway   ISOAKT1 (Homo sapiens)6484113 PIDPID:200014
Akt1Ratinsulin-like growth factor signaling pathway  ISOAKT1 (Homo sapiens)6484113 PIDPID:200100
Akt1Ratinterleukin-4 signaling pathway  ISOAKT1 (Homo sapiens)6484113 PIDPID:200022
Akt1Ratinterleukin-6 signaling pathway   ISOAKT1 (Homo sapiens)6484113 PIDPID:200146
Akt1RatmTOR signaling pathway   ISOAKT1 (Homo sapiens)6484113 PIDPID:200096
Akt1Ratp53 signaling pathway   ISOAKT1 (Homo sapiens)6484113 PIDPID:200206
Akt1Ratphosphatidylinositol 3-kinase-Akt signaling pathway   ISOAKT1 (Homo sapiens)6484113 PIDPID:200197
Akt1RatReelin signaling pathway   ISOAKT1 (Homo sapiens)6484113 PIDPID:200062
1 to 20 of 23 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Akt1Ratdecreased fetal weight  IMP 158013768 RGD 
Akt1Ratdecreased placenta weight  IMP 158013768 RGD 
Akt1Ratdecreased placental labyrinth size  IMP 158013768 RGD 

1 to 20 of 181 rows
#
Reference Title
Reference Citation
1. Altered Bad localization and interaction between Bad and Bcl-xL in the hippocampus after transient global ischemia. Abe T, etal., Brain Res. 2004 May 29;1009(1-2):159-68.
2. Over expression of proteins that alter the intracellular signaling pathways in the cytoplasm of the liver cells forming Mallory-Denk bodies. Afifiyan N, etal., Exp Mol Pathol. 2017 Feb;102(1):106-114. doi: 10.1016/j.yexmp.2017.01.011. Epub 2017 Jan 13.
3. Nuclear Akt associates with PKC-phosphorylated Ebp1, preventing DNA fragmentation by inhibition of caspase-activated DNase. Ahn JY, etal., EMBO J. 2006 May 17;25(10):2083-95. Epub 2006 Apr 27.
4. Nerve growth factor promotes activation of the alpha, beta and gamma isoforms of protein kinase B in PC12 pheochromocytoma cells. Andjelković M, etal., Eur J Biochem. 1998 Jan 15;251(1-2):195-200. doi: 10.1046/j.1432-1327.1998.2510195.x.
5. Glyceraldehyde-3-phosphate dehydrogenase interacts with phosphorylated Akt resulting from increased blood glucose in rat cardiac muscle. Baba T, etal., FEBS Lett. 2010 Jul 2;584(13):2796-800. doi: 10.1016/j.febslet.2010.05.015. Epub 2010 May 17.
6. Phosphorylated AKT expression is associated with PIK3CA mutation, low stage, and favorable outcome in 717 colorectal cancers. Baba Y, etal., Cancer. 2011 Apr 1;117(7):1399-408. doi: 10.1002/cncr.25630. Epub 2010 Nov 8.
7. Akt1 deficiency in schizophrenia and impairment of hippocampal plasticity and function. Balu DT, etal., Hippocampus. 2010 Nov 3.
8. Islet neogenesis-associated protein signaling in neonatal pancreatic rat islets: involvement of the cholinergic pathway. Barbosa HC, etal., J Endocrinol. 2008 Nov;199(2):299-306. doi: 10.1677/JOE-08-0309. Epub 2008 Sep 4.
9. Akt1 genetic deficiency limits hypothermia cardioprotection following murine cardiac arrest. Beiser DG, etal., Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H1761-8. Epub 2010 Apr 2.
10. Altered nitric oxide/cGMP platelet signaling pathway in platelets from patients with acute coronary syndromes. Bergandi L, etal., Clin Res Cardiol. 2010 Sep;99(9):557-64. Epub 2010 May 14.
11. The Akt pathway in human breast cancer: a tissue-array-based analysis. Bose S, etal., Mod Pathol. 2006 Feb;19(2):238-45.
12. Insulin increases the association of Akt-2 with Glut4-containing vesicles. Calera MR, etal., J Biol Chem. 1998 Mar 27;273(13):7201-4.
13. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Carpten JD, etal., Nature. 2007 Jul 26;448(7152):439-44. Epub 2007 Jul 4.
14. Differential Effects of PI3K and Dual PI3K/mTOR Inhibition in Rat Prolactin-Secreting Pituitary Tumors. Chanal M, etal., Mol Cancer Ther. 2016 Jun;15(6):1261-70. doi: 10.1158/1535-7163.MCT-15-0891. Epub 2016 Mar 16.
15. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Chen WS, etal., Genes Dev 2001 Sep 1;15(17):2203-8.
16. Leptin deficiency and beta-cell dysfunction underlie type 2 diabetes in compound Akt knockout mice. Chen WS, etal., Mol Cell Biol. 2009 Jun;29(11):3151-62. Epub 2009 Mar 16.
17. Caffeic acid phenethyl ester suppresses the proliferation of human prostate cancer cells through inhibition of p70S6K and Akt signaling networks. Chuu CP, etal., Cancer Prev Res (Phila). 2012 May;5(5):788-97. doi: 10.1158/1940-6207.CAPR-12-0004-T.
18. Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice. Condorelli G, etal., Proc Natl Acad Sci U S A 2002 Sep 17;99(19):12333-8.
19. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Cross DA, etal., Nature. 1995 Dec 21-28;378(6559):785-9.
20. Dissociation of Akt/PKB and ribosomal S6 kinase signaling markers in a transgenic mouse model of Alzheimer's disease. Damjanac M, etal., Neurobiol Dis. 2008 Feb;29(2):354-67. Epub 2007 Oct 11.
1 to 20 of 181 rows
1 to 10 of 54 rows
PMID:7891724   PMID:8940145   PMID:8978681   PMID:9373175   PMID:9415393   PMID:10102273   PMID:10376603   PMID:10983986   PMID:10995739   PMID:11282895   PMID:11809761   PMID:11834296  
PMID:11877387   PMID:11904450   PMID:11994271   PMID:12112022   PMID:12124386   PMID:12140361   PMID:12145204   PMID:12198247   PMID:12392981   PMID:12496370   PMID:12543452   PMID:12586553  
PMID:12624428   PMID:12734207   PMID:12761242   PMID:12767043   PMID:12783884   PMID:12789537   PMID:12810818   PMID:12816542   PMID:12816756   PMID:12818177   PMID:12829832   PMID:12837666  
PMID:12869584   PMID:13129932   PMID:14517300   PMID:14522978   PMID:14523027   PMID:14576824   PMID:14581516   PMID:14596918   PMID:14607273   PMID:14670845   PMID:14698990   PMID:14730361  
PMID:14749367   PMID:14753441   PMID:15007074   PMID:15010863   PMID:15024023   PMID:15065872   PMID:15149850   PMID:15192701   PMID:15203192   PMID:15249583   PMID:15282275   PMID:15289442  
PMID:15319368   PMID:15337841   PMID:15375154   PMID:15451022   PMID:15466647   PMID:15489316   PMID:15496504   PMID:15501455   PMID:15509711   PMID:15511630   PMID:15590660   PMID:15616009  
PMID:15632127   PMID:15632182   PMID:15637121   PMID:15694367   PMID:15706595   PMID:15713628   PMID:15713641   PMID:15775979   PMID:15797868   PMID:15809304   PMID:15814837   PMID:15845076  
PMID:15848222   PMID:15853465   PMID:15856020   PMID:15890358   PMID:15890643   PMID:15896702   PMID:15896972   PMID:15902400   PMID:15937334   PMID:15979279   PMID:16027121   PMID:16027165  
PMID:16046294   PMID:16049005   PMID:16061478   PMID:16087293   PMID:16098714   PMID:16116448   PMID:16123202   PMID:16139227   PMID:16141217   PMID:16142243   PMID:16171808   PMID:16181409  
PMID:16237183   PMID:16269516   PMID:16280327   PMID:16282323   PMID:16316997   PMID:16337154   PMID:16343426   PMID:16357133   PMID:16428351   PMID:16452480   PMID:16466740   PMID:16510873  
1 to 10 of 54 rows



Akt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86137,534,810 - 137,555,131 (-)NCBIGRCr8
mRatBN7.26131,713,716 - 131,735,319 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6131,713,720 - 131,733,921 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6131,883,770 - 131,900,905 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06132,180,876 - 132,197,963 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06131,543,341 - 131,560,403 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06137,218,398 - 137,239,970 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6137,218,376 - 137,236,258 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06146,225,955 - 146,247,008 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46137,640,482 - 137,657,552 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16137,646,668 - 137,663,739 (-)NCBI
Celera6129,262,032 - 129,279,096 (-)NCBICelera
RH 3.4 Map6782.49RGD
Cytogenetic Map6q32NCBI
AKT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814104,769,349 - 104,795,748 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14104,769,349 - 104,795,759 (-)EnsemblGRCh38hg38GRCh38
GRCh3714105,235,686 - 105,262,085 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3614104,306,731 - 104,333,125 (-)NCBINCBI36Build 36hg18NCBI36
Build 3414104,306,752 - 104,330,608NCBI
Celera1485,290,760 - 85,317,154 (-)NCBICelera
Cytogenetic Map14q32.33NCBI
HuRef1485,432,617 - 85,464,212 (-)NCBIHuRef
CHM1_114105,173,739 - 105,200,089 (-)NCBICHM1_1
T2T-CHM13v2.01499,012,235 - 99,038,624 (-)NCBIT2T-CHM13v2.0
Akt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912112,620,260 - 112,641,266 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12112,620,255 - 112,641,318 (-)EnsemblGRCm39 Ensembl
GRCm3812112,653,821 - 112,674,884 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12112,653,821 - 112,674,884 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712113,892,032 - 113,912,487 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612113,101,629 - 113,121,998 (-)NCBIMGSCv36mm8
Celera12113,867,449 - 113,888,183 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1261.2NCBI
Akt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555383,208,710 - 3,229,904 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555383,208,711 - 3,224,386 (-)NCBIChiLan1.0ChiLan1.0
AKT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215105,950,803 - 105,978,465 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114105,167,305 - 105,194,960 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01485,417,229 - 85,444,722 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114105,211,645 - 105,236,756 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14105,208,128 - 105,236,756 (-)Ensemblpanpan1.1panPan2
AKT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1872,317,399 - 72,335,686 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl872,317,869 - 72,335,193 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha871,823,163 - 71,843,039 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0872,592,378 - 72,612,252 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl872,592,384 - 72,609,857 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1872,275,001 - 72,294,850 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0872,318,256 - 72,338,331 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0872,717,834 - 72,737,716 (-)NCBIUU_Cfam_GSD_1.0
Akt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086401,791,300 - 1,810,158 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936621620,074 - 639,093 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936621620,163 - 639,115 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKT1
(Sus scrofa - pig)		 No map positions available.
AKT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12482,704,087 - 82,730,711 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2482,704,068 - 82,727,698 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605370,125,334 - 70,153,468 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Akt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624734509,368 - 525,295 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624734507,880 - 525,295 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

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Variants in Akt1
70 total Variants

Predicted Target Of
Summary Value
Count of predictions:65
Count of miRNA genes:61
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000031164
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 17 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6122549046137801795Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat

1 to 10 of 17 rows
RH94769  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26131,714,470 - 131,714,647 (+)MAPPERmRatBN7.2
Rnor_6.06137,219,153 - 137,219,329NCBIRnor6.0
Rnor_5.06146,226,709 - 146,226,885UniSTSRnor5.0
RGSC_v3.46137,640,504 - 137,640,680UniSTSRGSC3.4
Celera6129,262,054 - 129,262,230UniSTS
Cytogenetic Map6q32UniSTS
RH94504  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26131,714,459 - 131,714,541 (+)MAPPERmRatBN7.2
Rnor_6.06137,219,142 - 137,219,223NCBIRnor6.0
Rnor_5.06146,226,698 - 146,226,779UniSTSRnor5.0
RGSC_v3.46137,640,493 - 137,640,574UniSTSRGSC3.4
Celera6129,262,043 - 129,262,124UniSTS
RH 3.4 Map6782.49UniSTS
Cytogenetic Map6q32UniSTS
BE111601  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr86137,537,669 - 137,537,980 (+)Marker Load Pipeline
mRatBN7.26131,716,576 - 131,716,887 (+)MAPPERmRatBN7.2
Rnor_6.06137,221,261 - 137,221,571NCBIRnor6.0
Rnor_5.06146,228,817 - 146,229,127UniSTSRnor5.0
RGSC_v3.46137,642,612 - 137,642,922UniSTSRGSC3.4
Celera6129,264,162 - 129,264,472UniSTS
RH 3.4 Map6783.4UniSTS
Cytogenetic Map6q32UniSTS
PMC312770P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26131,718,480 - 131,719,046 (+)MAPPERmRatBN7.2
Rnor_6.06137,223,165 - 137,223,730NCBIRnor6.0
Rnor_5.06146,230,737 - 146,231,302UniSTSRnor5.0
RGSC_v3.46137,644,516 - 137,645,081UniSTSRGSC3.4
Celera6129,266,060 - 129,266,625UniSTS
Cytogenetic Map6q32UniSTS


This gene Akt1 is modified in the following models/strains:
SD-Akt1em1Soar    




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000031164   ⟹   ENSRNOP00000038369
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6131,713,725 - 131,722,390 (-)Ensembl
Rnor_6.0 Ensembl6137,218,376 - 137,236,258 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095849   ⟹   ENSRNOP00000097706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6131,713,725 - 131,722,908 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099722   ⟹   ENSRNOP00000076378
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6131,713,720 - 131,733,921 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110155   ⟹   ENSRNOP00000096272
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6131,714,449 - 131,731,517 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114705   ⟹   ENSRNOP00000090205
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6131,713,725 - 131,720,391 (-)Ensembl
RefSeq Acc Id: NM_033230   ⟹   NP_150233
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,535,542 - 137,552,610 (-)NCBI
mRatBN7.26131,714,449 - 131,731,517 (-)NCBI
Rnor_6.06137,219,131 - 137,236,201 (-)NCBI
Rnor_5.06146,225,955 - 146,247,008 (-)NCBI
RGSC_v3.46137,640,482 - 137,657,552 (-)RGD
Celera6129,262,032 - 129,279,096 (-)RGD
Sequence:
RefSeq Acc Id: XM_039111773   ⟹   XP_038967701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,534,810 - 137,555,131 (-)NCBI
mRatBN7.26131,713,717 - 131,734,163 (-)NCBI
RefSeq Acc Id: XM_063261541   ⟹   XP_063117611
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,534,810 - 137,554,837 (-)NCBI
Protein RefSeqs NP_150233 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967701 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117611 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA06279 (Get FASTA)   NCBI Sequence Viewer  
  EDL97422 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000090205
GenBank Protein P47196 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_150233   ⟸   NM_033230
- UniProtKB: P47196 (UniProtKB/Swiss-Prot),   A6KBV9 (UniProtKB/TrEMBL),   A0A8L2QJ86 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000038369   ⟸   ENSRNOT00000031164
RefSeq Acc Id: XP_038967701   ⟸   XM_039111773
- Peptide Label: isoform X1
- UniProtKB: P47196 (UniProtKB/Swiss-Prot),   A6KBV9 (UniProtKB/TrEMBL),   A0A8L2QJ86 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000097706   ⟸   ENSRNOT00000095849
Ensembl Acc Id: ENSRNOP00000076378   ⟸   ENSRNOT00000099722
AGC-kinase C-terminal   PH   Protein kinase

Name Modeler Protein Id AA Range Protein Structure
AF-P47196-F1-model_v2 AlphaFold P47196 1-480 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 43 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-35781 BioCyc
Ensembl Genes ENSRNOG00000028629 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000114705 ENTREZGENE
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro AGC-kinase_C UniProtKB/Swiss-Prot
  Akt1 UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
  PH_PKB UniProtKB/Swiss-Prot
  Pkinase_C UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:24185 UniProtKB/Swiss-Prot
NCBI Gene 24185 ENTREZGENE
PANTHER RIBOSOMAL PROTEIN S6 KINASE UniProtKB/Swiss-Prot
Pfam PF00169 UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
  Pkinase_C UniProtKB/Swiss-Prot
PharmGKB AKT1 RGD
PhenoGen Akt1 PhenoGen
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot
  PH_DOMAIN UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000028629 RatGTEx
SMART S_TK_X UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
  SM00233 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
TIGR TC204818
UniProt A0A8I5YBI2_RAT UniProtKB/TrEMBL
  A0A8I6AD70_RAT UniProtKB/TrEMBL
  A0A8I6AQF6_RAT UniProtKB/TrEMBL
  A0A8I6ASB8_RAT UniProtKB/TrEMBL
1 to 40 of 43 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Akt1  AKT serine/threonine kinase 1  Akt1  v-akt murine thymoma viral oncogene homolog 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Akt1  v-akt murine thymoma viral oncogene homolog 1  Akt1  thymoma viral proto-oncogene 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Akt1  thymoma viral proto-oncogene 1    v-akt murine thymoma viral oncogene homolog 1  Name updated 1299863 APPROVED
2004-12-14 Akt1  v-akt murine thymoma viral oncogene homolog 1      Symbol and Name status set to approved 1299863 APPROVED
2002-06-10 Akt1  v-akt murine thymoma viral oncogene homolog 1      Name updated 70585 PROVISIONAL
2001-03-05 Akt  Murine thymoma viral (v-akt) oncogene homolog 1      Symbol withdrawn, allele of Akt1 (RGD:2081) 61033 WITHDRAWN

Note Type Note Reference
gene_domains contains a pleckstrin homology domain 632176
gene_domains contains a protein-serine/threonine kinase catalytic domain 632176
gene_expression expressed in testis and other tissues 632176
gene_process may act as a protein-serine/threonine kinase 632176
gene_process may bind protein kinase C 632176
gene_process inhibits JUN kinase activation and reduces JNK mediated apoptosis 632178
gene_protein protein sequence contains 480 amino acids 632176
gene_regulation activity is induced by insulin 632177