Symbol:
Agtr1a
Name:
angiotensin II receptor, type 1a
RGD ID:
2070
Description:
Enables D1 dopamine receptor binding activity; angiotensin type I receptor activity; and protein kinase binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; positive regulation of metabolic process; and response to glucocorticoid. Located in several cellular components, including basolateral plasma membrane; organelle outer membrane; and recycling endosome. Used to study several diseases, including asthma; chronic kidney disease; congestive heart failure; hypertension (multiple); and nephritis. Biomarker of several diseases, including anti-basement membrane glomerulonephritis; artery disease (multiple); glomerulosclerosis (multiple); hyperinsulinism; and placental insufficiency. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; artery disease (multiple); chronic kidney disease; neurodegenerative disease (multiple); and sarcoidosis. Orthologous to human AGTR1 (angiotensin II receptor type 1); PARTICIPATES IN angiotensin II signaling pathway via AT1 receptor; G protein mediated signaling pathway via Galpha12/Galpha13 family; G protein mediated signaling pathway via Galphaq family; INTERACTS WITH (+)-pilocarpine; (R)-lipoic acid; (S)-nicotine.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Previously known as:
Agtr1; Angiotensin II receptor type 1 (AT1A); angiotensin II receptor, type 1; Angiotensin II receptor, type 1 (AT1A); angiotensin II type-1 receptor A; angiotensin II type-1A receptor; angiotensin receptor 1a; AT1; AT1 receptor A; AT1A; AT1R; type-1 angiotensin II receptor A; type-1A angiotensin II receptor; vascular type-1 angiotensin II receptor
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
AGTR1 (angiotensin II receptor type 1) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Agtr1a (angiotensin II receptor, type 1a) RGD
RGD
Chinchilla lanigera (long-tailed chinchilla):
Agtr1 (angiotensin II receptor type 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
AGTR1 (angiotensin II receptor type 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
AGTR1 (angiotensin II receptor type 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Agtr1 (angiotensin II receptor type 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
AGTR1 (angiotensin II receptor type 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
AGTR1 (angiotensin II receptor type 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Agtr1 (angiotensin II receptor type 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
KREMEN1 (kringle containing transmembrane protein 1) HGNC
OMA
Alliance orthologs 3
Homo sapiens (human):
AGTR1 (angiotensin II receptor type 1)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Mus musculus (house mouse):
Agtr1a (angiotensin II receptor, type 1a)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Danio rerio (zebrafish):
agtr1b (angiotensin II receptor, type 1b)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Danio rerio (zebrafish):
agtr1a (angiotensin II receptor, type 1a)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Caenorhabditis elegans (roundworm):
npr-33
Alliance
DIOPT (Ensembl Compara|PANTHER)
Caenorhabditis elegans (roundworm):
npr-15
Alliance
DIOPT (Ensembl Compara|PANTHER)
Xenopus tropicalis (tropical clawed frog):
agtr1
Alliance
DIOPT (Ensembl Compara|OMA|OrthoFinder|PANTHER|PhylomeDB)
Allele / Splice:
Agtr1aem5Mcwi ;
Agtr1aem1Mcwi
Genetic Models:
SS-Agtr1aem1Mcwi ;
SS-Agtr1aem5Mcwi
Is Marker For:
QTLs:
Bp343
Candidate Gene For:
Bp343
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 17 34,383,397 - 34,435,523 (-) NCBI GRCr8 mRatBN7.2 17 34,173,446 - 34,226,892 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 17 34,174,429 - 34,226,946 (-) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 17 34,003,015 - 34,054,637 (-) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 17 35,606,893 - 35,658,508 (-) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 17 33,998,820 - 34,050,440 (-) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 17 35,907,102 - 35,958,136 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 17 35,907,108 - 35,958,077 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 17 37,217,810 - 37,270,540 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 17 40,629,318 - 40,684,982 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 17 40,632,160 - 40,687,823 (-) NCBI Celera 17 33,705,975 - 33,757,157 (-) NCBI Celera Cytogenetic Map 17 p12 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Agtr1a Rat aceruloplasminemia ISO RGD:68977 8554872 ClinVar Annotator: match by term: Deficiency of ferroxidase ClinVar PMID:16629161|PMID:28492532 Agtr1a Rat diffuse cystic renal dysplasia ISO RGD:68977 8554872 ClinVar Annotator: match by term: Renal dysplasia, cystic, susceptibility to ClinVar PMID:25741868|PMID:35005812 Agtr1a Rat essential hypertension ISO RGD:68977 8554872 ClinVar Annotator: match by term: Essential hypertension | ClinVar Annotator: match by term: Essential hypertension, more ... ClinVar PMID:15042429|PMID:16116425|PMID:17668390|PMID:22095942|PMID:25741868|PMID:28492532|PMID:28973083|PMID:8021009|PMID:9084931 Agtr1a Rat genetic disease ISO RGD:68977 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:25741868|PMID:28492532 Agtr1a Rat glycogen storage disease XV ISO RGD:68977 8554872 ClinVar Annotator: match by term: Glycogen storage disease XV ClinVar PMID:20357282|PMID:25272951|PMID:28492532 Agtr1a Rat Renal Tubular Dysgenesis ISO RGD:68977 8554872 ClinVar Annotator: match by term: Renal tubular dysgenesis | ClinVar Annotator: match by term: Renal more ... ClinVar PMID:15042429|PMID:16116425|PMID:17668390|PMID:18641512|PMID:20948563|PMID:21179236|PMID:22095942|PMID:22569962|PMID:24033266|PMID:25741868|PMID:26220970|PMID:28492532|PMID:28973083|PMID:35005812|PMID:8021009|PMID:9084931
Only show annotations with direct experimental evidence (0 objects hidden)
Agtr1a Rat (+)-pilocarpine multiple interactions EXP 6480464 [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of AGTR1A more ... CTD PMID:32494933 Agtr1a Rat (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:68977 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of AGTR1 mRNA; epigallocatechin gallate more ... CTD PMID:22079256|PMID:36162953 Agtr1a Rat (1->4)-beta-D-glucan multiple interactions ISO RGD:737190 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of AGTR1A mRNA CTD PMID:36331819 Agtr1a Rat (R)-lipoic acid multiple interactions ISO RGD:737190 6480464 Thioctic Acid affects the reaction [Dietary Fats affects the expression of AGTR1A mRNA] CTD PMID:27260466 Agtr1a Rat (R)-lipoic acid multiple interactions EXP 6480464 Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of AGTR1] CTD PMID:26518973 Agtr1a Rat (S)-nicotine increases expression EXP 6480464 Nicotine results in increased expression of AGTR1A protein CTD PMID:22691361 Agtr1a Rat 1,1-dichloroethene decreases expression ISO RGD:737190 6480464 vinylidene chloride results in decreased expression of AGTR1A mRNA CTD PMID:26682919 Agtr1a Rat 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactions ISO RGD:737190 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Agtr1a Rat 1,2-dimethylhydrazine decreases expression ISO RGD:737190 6480464 1,2-Dimethylhydrazine results in decreased expression of AGTR1A mRNA CTD PMID:22206623 Agtr1a Rat 1,2-dimethylhydrazine multiple interactions ISO RGD:737190 6480464 Folic Acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of AGTR1A mRNA] CTD PMID:22206623 Agtr1a Rat 1-naphthyl isothiocyanate decreases expression EXP 6480464 1-Naphthylisothiocyanate results in decreased expression of AGTR1A mRNA CTD PMID:25380136 Agtr1a Rat 1-naphthyl isothiocyanate multiple interactions ISO RGD:68977 6480464 [1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of AGTR1 mRNA CTD PMID:27344345 Agtr1a Rat 1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine increases expression ISO RGD:68977 6480464 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of AGTR1 mRNA CTD PMID:16386258 Agtr1a Rat 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of AGTR1A mRNA CTD PMID:17351261|PMID:17557909 Agtr1a Rat 17beta-estradiol multiple interactions ISO RGD:68977 6480464 Estradiol inhibits the reaction [AGT protein results in increased expression of AGTR1 mRNA]; Estradiol inhibits more ... CTD PMID:16097371 Agtr1a Rat 17beta-estradiol increases expression ISO RGD:737190 6480464 Estradiol results in increased expression of AGTR1A mRNA CTD PMID:39298647 Agtr1a Rat 17beta-estradiol decreases expression ISO RGD:68977 6480464 Estradiol results in decreased expression of AGTR1 mRNA CTD PMID:15159206|PMID:20106945|PMID:21632981 Agtr1a Rat 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of AGTR1 mRNA; Estradiol results in increased expression of AGTR1A more ... CTD PMID:17021606|PMID:32145629 Agtr1a Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:737190 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Agtr1a Rat 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO RGD:737190 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Agtr1a Rat 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of AGTR1A mRNA] CTD PMID:21215274 Agtr1a Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 401793709 2,3,7,8-tetrachlorodibenzodioxine in pregnant dams increases expression of mRNA in kidney of male offspring RGD Agtr1a Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of AGTR1A mRNA CTD PMID:34747641 Agtr1a Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:68977 6480464 Tetrachlorodibenzodioxin results in decreased expression of AGTR1 mRNA CTD PMID:20106945|PMID:21632981 Agtr1a Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:68977 6480464 Tetrachlorodibenzodioxin affects the expression of AGTR1 mRNA CTD PMID:22298810 Agtr1a Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of AGTR1A mRNA CTD PMID:21215274|PMID:33387578 Agtr1a Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:737190 6480464 Tetrachlorodibenzodioxin results in decreased expression of AGTR1A mRNA CTD PMID:19770486 Agtr1a Rat 2,4,4'-trichlorobiphenyl multiple interactions ISO RGD:737190 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Agtr1a Rat 2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expression ISO RGD:737190 6480464 2,2',4,4',5-brominated diphenyl ether affects the expression of AGTR1A mRNA CTD PMID:38648751 Agtr1a Rat 2,5-dihydroxybenzoic acid multiple interactions ISO RGD:737190 6480464 2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of AGTR1A more ... CTD PMID:37120126 Agtr1a Rat 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine increases expression ISO RGD:68977 6480464 Platelet Activating Factor results in increased expression of AGTR1 mRNA CTD PMID:16386258 Agtr1a Rat 2-butoxyethanol increases expression ISO RGD:737190 6480464 n-butoxyethanol results in increased expression of AGTR1A mRNA CTD PMID:19812364 Agtr1a Rat 2-palmitoylglycerol increases expression ISO RGD:68977 6480464 2-palmitoylglycerol results in increased expression of AGTR1 mRNA CTD PMID:37199045 Agtr1a Rat 3,3',4,4',5-pentachlorobiphenyl increases expression ISO RGD:68977 6480464 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of AGTR1 mRNA CTD PMID:14962509 Agtr1a Rat 3,3',4,4'-tetrachlorobiphenyl increases expression ISO RGD:737190 6480464 3,4,3',4'-tetrachlorobiphenyl results in increased expression of AGTR1 mRNA CTD PMID:21925196 Agtr1a Rat 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:68977 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ... CTD PMID:28628672 Agtr1a Rat 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1,2-dithiol-3-thione results in decreased expression of AGTR1A mRNA CTD PMID:19162173 Agtr1a Rat 4,4'-diaminodiphenylmethane decreases expression EXP 6480464 4,4'-diaminodiphenylmethane results in decreased expression of AGTR1A mRNA CTD PMID:25380136 Agtr1a Rat 4,4'-sulfonyldiphenol increases methylation ISO RGD:68977 6480464 bisphenol S results in increased methylation of AGTR1 gene CTD PMID:31601247 Agtr1a Rat 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile decreases expression EXP 6480464 Fadrozole results in decreased expression of AGTR1 protein CTD PMID:18586661 Agtr1a Rat 4-hydroxy-TEMPO multiple interactions ISO RGD:737190 6480464 tempol inhibits the reaction [[AGT protein modified form co-treated with AGTR1A co-treated with AGTR1B] results more ... CTD PMID:17620961 Agtr1a Rat 4-hydroxyphenyl retinamide increases expression ISO RGD:737190 6480464 Fenretinide results in increased expression of AGTR1 mRNA CTD PMID:28973697 Agtr1a Rat 5-aza-2'-deoxycytidine increases expression EXP 6480464 Decitabine results in increased expression of AGTR1 protein CTD PMID:34536542 Agtr1a Rat 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole affects expression EXP 6480464 Omeprazole affects the expression of AGTR1A mRNA CTD PMID:19483382 Agtr1a Rat 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of AGTR1A mRNA CTD PMID:24780913 Agtr1a Rat 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of AGTR1A mRNA CTD PMID:25825206 Agtr1a Rat 6-propyl-2-thiouracil affects expression EXP 6480464 Propylthiouracil affects the expression of AGTR1A mRNA CTD PMID:19483382 Agtr1a Rat 7,9-dihydro-1H-purine-2,6,8(3H)-trione multiple interactions ISO RGD:737190 6480464 APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of AGTR1A more ... CTD PMID:30710622 Agtr1a Rat 7,9-dihydro-1H-purine-2,6,8(3H)-trione increases expression ISO RGD:737190 6480464 Uric Acid results in increased expression of AGTR1A mRNA CTD PMID:30710622 Agtr1a Rat 8-Br-cAMP decreases expression ISO RGD:68977 6480464 8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of AGTR1 mRNA CTD PMID:22079614 Agtr1a Rat Ac-Ser-Asp-Lys-Pro-OH multiple interactions ISO RGD:737190 6480464 ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression more ... CTD PMID:33007385 Agtr1a Rat acetylsalicylic acid multiple interactions ISO RGD:737190 6480464 Aspirin inhibits the reaction [Hydrogen Peroxide results in increased expression of AGTR1A mRNA] CTD PMID:22306536 Agtr1a Rat aflatoxin B1 affects expression ISO RGD:68977 6480464 Aflatoxin B1 affects the expression of AGTR1 protein CTD PMID:20106945 Agtr1a Rat aflatoxin B1 decreases methylation ISO RGD:68977 6480464 Aflatoxin B1 results in decreased methylation of AGTR1 gene CTD PMID:27153756 Agtr1a Rat aflatoxin B1 decreases expression ISO RGD:68977 6480464 Aflatoxin B1 results in decreased expression of AGTR1 mRNA CTD PMID:22100608 Agtr1a Rat aflatoxin B1 decreases expression ISO RGD:737190 6480464 Aflatoxin B1 results in decreased expression of AGTR1A mRNA CTD PMID:19770486 Agtr1a Rat aldehydo-D-glucose increases expression ISO RGD:68977 6480464 Glucose results in increased expression of AGTR1 mRNA; Glucose results in increased expression of AGTR1 more ... CTD PMID:16452552|PMID:31655124|PMID:34464088 Agtr1a Rat aldehydo-D-glucose multiple interactions ISO RGD:737190 6480464 CEBPB protein inhibits the reaction [Glucose results in increased expression of AGTR1 protein] CTD PMID:29266779 Agtr1a Rat aldehydo-D-glucose increases expression ISO RGD:737190 6480464 Glucose results in increased expression of AGTR1 protein CTD PMID:29266779 Agtr1a Rat aldehydo-D-glucose multiple interactions ISO RGD:68977 6480464 Enalaprilat inhibits the reaction [Glucose results in increased expression of AGTR1 protein] CTD PMID:16452552 Agtr1a Rat aldosterone increases expression EXP 6480464 Aldosterone results in increased expression of AGTR1A mRNA CTD PMID:15302841|PMID:9087624 Agtr1a Rat aldosterone multiple interactions ISO RGD:68977 6480464 [Losartan results in decreased activity of AGTR1 protein] which results in decreased abundance of Aldosterone CTD PMID:9124547 Agtr1a Rat all-trans-retinoic acid increases expression ISO RGD:68977 6480464 Tretinoin results in increased expression of AGTR1 mRNA CTD PMID:21934132 Agtr1a Rat all-trans-retinoic acid multiple interactions ISO RGD:737190 6480464 [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in increased expression of AGTR1A mRNA CTD PMID:36189433 Agtr1a Rat all-trans-retinoic acid increases expression ISO RGD:737190 6480464 Tretinoin results in increased expression of AGTR1A mRNA CTD PMID:36189433 Agtr1a Rat all-trans-retinoic acid decreases expression ISO RGD:68977 6480464 Tretinoin results in decreased expression of AGTR1 mRNA CTD PMID:23724009 Agtr1a Rat AM6545 multiple interactions ISO RGD:737190 6480464 [Perindopril co-treated with AM6545] inhibits the reaction [Streptozocin results in increased expression of AGTR1A protein]; more ... CTD PMID:30184259 Agtr1a Rat amiodarone affects expression EXP 6480464 Amiodarone affects the expression of AGTR1A mRNA CTD PMID:19483382 Agtr1a Rat amlodipine decreases expression EXP 6480464 Amlodipine results in decreased expression of AGTR1A mRNA CTD PMID:18403896 Agtr1a Rat anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO RGD:737190 6480464 pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of AGTR1 mRNA] CTD PMID:23603059 Agtr1a Rat antirheumatic drug increases expression ISO RGD:68977 6480464 Antirheumatic Agents results in increased expression of AGTR1 mRNA CTD PMID:24449571 Agtr1a Rat Aroclor 1254 decreases expression ISO RGD:737190 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of AGTR1A mRNA CTD PMID:25270620 Agtr1a Rat arsenite(3-) increases methylation ISO RGD:68977 6480464 arsenite results in increased methylation of AGTR1 promoter CTD PMID:23974009 Agtr1a Rat arsenous acid decreases expression ISO RGD:68977 6480464 Arsenic Trioxide results in decreased expression of AGTR1 mRNA CTD PMID:26705709 Agtr1a Rat asbestos decreases expression ISO RGD:68977 6480464 Asbestos results in decreased expression of AGTR1 mRNA CTD PMID:22398240 Agtr1a Rat aspartame decreases expression ISO RGD:68977 6480464 Aspartame results in decreased expression of AGTR1 mRNA CTD PMID:31655124 Agtr1a Rat ATP multiple interactions EXP 6480464 Adenosine Triphosphate results in decreased expression of and results in decreased activity of AGTR1A protein; more ... CTD PMID:21464294 Agtr1a Rat ATP decreases expression EXP 6480464 Adenosine Triphosphate results in decreased expression of AGTR1A mRNA CTD PMID:21464294 Agtr1a Rat benazepril decreases expression EXP 6480464 benazepril results in decreased expression of AGTR1A mRNA; benazepril results in decreased expression of AGTR1A more ... CTD PMID:9596920 Agtr1a Rat benazepril multiple interactions ISO RGD:68977 6480464 [AGT gene polymorphism co-treated with AGTR1 gene polymorphism] affects the susceptibility to benazepril CTD PMID:21449848 Agtr1a Rat benazepril multiple interactions EXP 6480464 benazepril inhibits the reaction [Doxorubicin results in increased expression of AGTR1 protein] CTD PMID:15157388 Agtr1a Rat benzbromarone affects expression EXP 6480464 Benzbromarone affects the expression of AGTR1A mRNA CTD PMID:19483382 Agtr1a Rat benzo[a]pyrene decreases expression ISO RGD:737190 6480464 Benzo(a)pyrene results in decreased expression of AGTR1A mRNA CTD PMID:22228805 Agtr1a Rat benzo[a]pyrene decreases expression ISO RGD:68977 6480464 Benzo(a)pyrene results in decreased expression of AGTR1 mRNA CTD PMID:32234424 Agtr1a Rat benzo[a]pyrene affects methylation ISO RGD:68977 6480464 Benzo(a)pyrene affects the methylation of AGTR1 5' UTR CTD PMID:27901495 Agtr1a Rat benzo[a]pyrene increases methylation ISO RGD:68977 6480464 Benzo(a)pyrene results in increased methylation of AGTR1 exon; Benzo(a)pyrene results in increased methylation of AGTR1 more ... CTD PMID:27901495 Agtr1a Rat beta-hexachlorocyclohexane decreases expression ISO RGD:737190 6480464 beta-hexachlorocyclohexane results in decreased expression of AGTR1A mRNA CTD PMID:25270620 Agtr1a Rat bis(2-ethylhexyl) phthalate increases expression ISO RGD:737190 6480464 Diethylhexyl Phthalate results in increased expression of AGTR1A mRNA CTD PMID:34319233 Agtr1a Rat bisphenol A decreases expression ISO RGD:737190 6480464 bisphenol A results in decreased expression of AGTR1A mRNA CTD PMID:21932408|PMID:33221593 Agtr1a Rat bisphenol A decreases methylation ISO RGD:68977 6480464 bisphenol A results in decreased methylation of AGTR1 gene CTD PMID:31601247 Agtr1a Rat bisphenol A multiple interactions ISO RGD:68977 6480464 [bisphenol A co-treated with Fulvestrant] results in increased methylation of AGTR1 gene; [INS protein co-treated more ... CTD PMID:28628672|PMID:31601247 Agtr1a Rat bisphenol A increases expression ISO RGD:68977 6480464 bisphenol A results in increased expression of AGTR1 mRNA CTD PMID:27685785 Agtr1a Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of AGTR1 mRNA; bisphenol A results in decreased expression more ... CTD PMID:25181051|PMID:30816183 Agtr1a Rat bleomycin A2 multiple interactions EXP 6480464 angiotensin I (1-7) inhibits the reaction [Bleomycin results in increased expression of AGTR1 protein] CTD PMID:20581171 Agtr1a Rat bleomycin A2 increases expression EXP 6480464 Bleomycin results in increased expression of AGTR1 protein CTD PMID:20581171 Agtr1a Rat butanal decreases expression ISO RGD:68977 6480464 butyraldehyde results in decreased expression of AGTR1 mRNA CTD PMID:26079696 Agtr1a Rat cadmium dichloride decreases expression ISO RGD:68977 6480464 Cadmium Chloride results in decreased expression of AGTR1 mRNA CTD PMID:38382870 Agtr1a Rat caffeine increases expression EXP 6480464 Caffeine results in increased expression of AGTR1A CTD PMID:25986755 Agtr1a Rat caffeine decreases expression EXP 6480464 Caffeine results in decreased expression of AGTR1A mRNA CTD PMID:30423288 Agtr1a Rat calcium atom affects expression EXP 6480464 Calcium affects the expression of AGTR1A mRNA CTD PMID:15913539 Agtr1a Rat calcium(0) affects expression EXP 6480464 Calcium affects the expression of AGTR1A mRNA CTD PMID:15913539 Agtr1a Rat candesartan decreases expression EXP 6480464 candesartan results in decreased expression of AGTR1A mRNA CTD PMID:18796534 Agtr1a Rat candesartan multiple interactions ISO RGD:68977 6480464 candesartan binds to and results in decreased activity of AGTR1 protein CTD PMID:21474964 Agtr1a Rat candesartan multiple interactions EXP 6480464 candesartan inhibits the reaction [Folic Acid results in increased localization of [AGT protein binds to more ... CTD PMID:15728788 Agtr1a Rat Candesartan cilexetil multiple interactions EXP 6480464 candesartan cilexetil binds to and results in decreased activity of AGTR1A protein CTD PMID:15667801 Agtr1a Rat capsaicin increases expression EXP 6480464 Capsaicin results in increased expression of AGTR1A mRNA CTD PMID:20349343 Agtr1a Rat captopril multiple interactions EXP 6480464 Captopril inhibits the reaction [Pregabalin results in increased expression of AGTR1 protein] CTD PMID:31629013 Agtr1a Rat captopril multiple interactions ISO RGD:737190 6480464 Captopril inhibits the reaction [AGT protein results in increased expression of AGTR1 protein]; Captopril inhibits more ... CTD PMID:28130181|PMID:33007385 Agtr1a Rat CGP 52608 multiple interactions ISO RGD:68977 6480464 CGP 52608 promotes the reaction [RORA protein binds to AGTR1 gene] CTD PMID:28238834 Agtr1a Rat chlordecone increases expression ISO RGD:737190 6480464 Chlordecone results in increased expression of AGTR1A mRNA CTD PMID:33711761 Agtr1a Rat chlorpyrifos increases expression ISO RGD:737190 6480464 Chlorpyrifos results in increased expression of AGTR1A mRNA CTD PMID:37019170 Agtr1a Rat cholesterol increases expression ISO RGD:737190 6480464 Cholesterol results in increased expression of AGTR1 mRNA CTD PMID:19028402 Agtr1a Rat cholesterol multiple interactions ISO RGD:737190 6480464 Cholesterol inhibits the reaction [irbesartan results in increased expression of AGTR1 mRNA] CTD PMID:19028402 Agtr1a Rat chromium(6+) affects expression ISO RGD:68977 6480464 chromium hexavalent ion affects the expression of AGTR1 mRNA CTD PMID:30690063 Agtr1a Rat cilazapril monohydrate multiple interactions EXP 6480464 [Cilazapril co-treated with Losartan] promotes the reaction [Doxorubicin results in increased expression of AGTR1 mRNA]; more ... CTD PMID:15331931 Agtr1a Rat clofibrate affects expression EXP 6480464 Clofibrate affects the expression of AGTR1A mRNA CTD PMID:19483382 Agtr1a Rat clofibric acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of AGTR1A mRNA CTD PMID:17602206 Agtr1a Rat cobalt dichloride increases expression ISO RGD:737190 6480464 cobaltous chloride results in increased expression of AGTR1 mRNA CTD PMID:25511041 Agtr1a Rat cobalt dichloride decreases expression ISO RGD:737190 6480464 cobaltous chloride results in decreased expression of AGTR1 mRNA; cobaltous chloride results in decreased expression more ... CTD PMID:21825224 Agtr1a Rat corticosterone multiple interactions EXP 6480464 Mifepristone inhibits the reaction [Corticosterone results in increased expression of AGTR1A mRNA] CTD PMID:30423288 Agtr1a Rat corticosterone decreases expression EXP 6480464 Corticosterone results in decreased expression of AGTR1A mRNA CTD PMID:30423288 Agtr1a Rat cyclosporin A multiple interactions EXP 6480464 Cyclosporine inhibits the reaction [Adenosine Triphosphate results in decreased expression of AGTR1A mRNA]; Enalapril inhibits more ... CTD PMID:14659064|PMID:21464294 Agtr1a Rat cyclosporin A decreases methylation ISO RGD:68977 6480464 Cyclosporine results in decreased methylation of AGTR1 promoter CTD PMID:27989131 Agtr1a Rat cyclosporin A decreases expression ISO RGD:68977 6480464 Cyclosporine results in decreased expression of AGTR1 mRNA CTD PMID:20106945|PMID:25562108 Agtr1a Rat cyclosporin A multiple interactions ISO RGD:68977 6480464 [Cyclosporine co-treated with Cholic Acids] affects the expression of AGTR1 mRNA CTD PMID:27344345 Agtr1a Rat cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of AGTR1A mRNA CTD PMID:14659064 Agtr1a Rat D-glucose multiple interactions ISO RGD:68977 6480464 Enalaprilat inhibits the reaction [Glucose results in increased expression of AGTR1 protein] CTD PMID:16452552 Agtr1a Rat D-glucose increases expression ISO RGD:737190 6480464 Glucose results in increased expression of AGTR1 protein CTD PMID:29266779 Agtr1a Rat D-glucose multiple interactions ISO RGD:737190 6480464 CEBPB protein inhibits the reaction [Glucose results in increased expression of AGTR1 protein] CTD PMID:29266779 Agtr1a Rat D-glucose increases expression ISO RGD:68977 6480464 Glucose results in increased expression of AGTR1 mRNA; Glucose results in increased expression of AGTR1 more ... CTD PMID:16452552|PMID:31655124|PMID:34464088 Agtr1a Rat daunorubicin multiple interactions EXP 6480464 telmisartan inhibits the reaction [Daunorubicin results in increased expression of AGTR1A protein] CTD PMID:20888384 Agtr1a Rat daunorubicin increases expression EXP 6480464 Daunorubicin results in increased expression of AGTR1A protein CTD PMID:20888384 Agtr1a Rat decabromodiphenyl ether decreases expression EXP 6480464 decabromobiphenyl ether results in decreased expression of AGTR1A mRNA CTD PMID:23914054 Agtr1a Rat decabromodiphenyl ether increases expression EXP 6480464 decabromobiphenyl ether results in increased expression of AGTR1A mRNA CTD PMID:23914054 Agtr1a Rat dexamethasone increases expression ISO RGD:737190 6480464 Dexamethasone results in increased expression of AGTR1 protein; Dexamethasone results in increased expression of AGTR1A more ... CTD PMID:23935943|PMID:30940551 Agtr1a Rat dexamethasone affects expression EXP 6480464 Dexamethasone affects the expression of AGTR1 mRNA CTD PMID:30359671 Agtr1a Rat dexamethasone multiple interactions ISO RGD:737190 6480464 diisononyl phthalate promotes the reaction [Dexamethasone results in increased expression of AGTR1 protein]; Enalapril inhibits more ... CTD PMID:30940551 Agtr1a Rat dexamethasone multiple interactions ISO RGD:68977 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ... CTD PMID:28628672 Agtr1a Rat dexamethasone increases expression EXP 6480464 Dexamethasone results in increased expression of AGTR1A mRNA; Dexamethasone results in increased expression of AGTR1A more ... CTD PMID:32494933 Agtr1a Rat dexamethasone multiple interactions EXP 6480464 [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of AGTR1A more ... CTD PMID:32494933 Agtr1a Rat diarsenic trioxide decreases expression ISO RGD:68977 6480464 Arsenic Trioxide results in decreased expression of AGTR1 mRNA CTD PMID:26705709 Agtr1a Rat dibenz[a,h]anthracene increases expression ISO RGD:737190 6480464 1,2,5,6-dibenzanthracene results in increased expression of AGTR1A mRNA CTD PMID:26377693 Agtr1a Rat dibutyl phthalate increases expression ISO RGD:68977 6480464 Dibutyl Phthalate results in increased expression of AGTR1 protein CTD PMID:37356649 Agtr1a Rat diisononyl phthalate multiple interactions ISO RGD:737190 6480464 diisononyl phthalate promotes the reaction [Dexamethasone results in increased expression of AGTR1 protein]; Enalapril inhibits more ... CTD PMID:30940551 Agtr1a Rat diisononyl phthalate increases expression ISO RGD:737190 6480464 diisononyl phthalate results in increased expression of AGTR1 protein CTD PMID:30940551 Agtr1a Rat diminazene diaceturate multiple interactions ISO RGD:68977 6480464 ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression more ... CTD PMID:26862037 Agtr1a Rat dioxygen affects expression ISO RGD:737190 6480464 Oxygen deficiency affects the expression of AGTR1 protein CTD PMID:25511041 Agtr1a Rat dioxygen decreases expression ISO RGD:737190 6480464 Oxygen deficiency results in decreased expression of AGTR1 protein CTD PMID:21825224 Agtr1a Rat dioxygen multiple interactions ISO RGD:737190 6480464 Losartan inhibits the reaction [Oxygen deficiency results in increased expression of AGTR1 protein] CTD PMID:25511041 Agtr1a Rat dioxygen decreases expression EXP 6480464 Oxygen deficiency results in decreased expression of AGTR1A mRNA; Oxygen deficiency results in decreased expression more ... CTD PMID:19118600 Agtr1a Rat dipentyl phthalate decreases expression EXP 6480464 di-n-pentyl phthalate results in decreased expression of AGTR1A mRNA; di-n-pentyl phthalate results in decreased expression more ... CTD PMID:36715143 Agtr1a Rat diuron decreases expression EXP 6480464 Diuron results in decreased expression of AGTR1A mRNA CTD PMID:25152437 Agtr1a Rat doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of AGTR1 mRNA; Doxorubicin results in increased expression of AGTR1 more ... CTD PMID:15157388|PMID:15331931|PMID:36636964 Agtr1a Rat doxorubicin multiple interactions EXP 6480464 [Cilazapril co-treated with Losartan] promotes the reaction [Doxorubicin results in increased expression of AGTR1 mRNA]; more ... CTD PMID:15157388|PMID:15331931|PMID:36636964 Agtr1a Rat EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor increases expression EXP 6480464 Angiotensin-Converting Enzyme Inhibitors results in increased expression of AGTR1 mRNA CTD PMID:9533614 Agtr1a Rat edaravone multiple interactions EXP 6480464 Edaravone inhibits the reaction [Lipopolysaccharides results in decreased expression of AGTR1A mRNA] CTD PMID:19118600 Agtr1a Rat ellagic acid multiple interactions EXP 6480464 Ellagic Acid inhibits the reaction [AGT protein results in increased expression of AGTR1 protein] CTD PMID:38356441 Agtr1a Rat enalapril affects expression EXP 6480464 Enalapril affects the expression of AGTR1A mRNA CTD PMID:18796534 Agtr1a Rat enalapril multiple interactions ISO RGD:737190 6480464 Enalapril inhibits the reaction [Dexamethasone results in increased expression of AGTR1 protein]; Enalapril inhibits the more ... CTD PMID:30940551|PMID:36706861 Agtr1a Rat enalapril decreases expression EXP 6480464 Enalapril results in decreased expression of AGTR1A mRNA CTD PMID:18403896|PMID:18765277 Agtr1a Rat enalapril multiple interactions EXP 6480464 Enalapril inhibits the reaction [Cyclosporine results in decreased expression of AGTR1A mRNA] CTD PMID:14659064 Agtr1a Rat enalapril increases expression EXP 6480464 Enalapril results in increased expression of AGTR1A mRNA CTD PMID:18796534 Agtr1a Rat enalaprilat dihydrate multiple interactions ISO RGD:68977 6480464 Enalaprilat inhibits the reaction [Glucose results in increased expression of AGTR1 protein] CTD PMID:16452552 Agtr1a Rat endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of AGTR1A mRNA CTD PMID:29391264 Agtr1a Rat esculetin multiple interactions EXP 6480464 esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGTR1A more ... CTD PMID:28946194 Agtr1a Rat estriol decreases expression ISO RGD:68977 6480464 Estriol results in decreased expression of AGTR1 mRNA CTD PMID:15159206 Agtr1a Rat ethanol increases expression EXP 6480464 Ethanol results in increased expression of AGTR1A mRNA CTD PMID:25151222|PMID:29548890 Agtr1a Rat ethanol decreases expression EXP 6480464 Ethanol results in decreased expression of AGTR1A mRNA; Ethanol results in decreased expression of AGTR1A more ... CTD PMID:31887396 Agtr1a Rat ethanol multiple interactions EXP 6480464 Ethanol affects the reaction [Dietary Fats affects the expression of AGTR1 mRNA]; Ethanol affects the more ... CTD PMID:31811911 Agtr1a Rat flavonoids decreases expression EXP 6480464 Flavonoids results in decreased expression of AGTR1A mRNA CTD PMID:18035473 Agtr1a Rat folic acid multiple interactions EXP 6480464 candesartan inhibits the reaction [Folic Acid results in increased localization of [AGT protein binds to more ... CTD PMID:15728788 Agtr1a Rat folic acid multiple interactions ISO RGD:737190 6480464 Folic Acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of AGTR1A mRNA] CTD PMID:22206623 Agtr1a Rat folic acid decreases expression ISO RGD:737190 6480464 Folic Acid results in decreased expression of AGTR1A mRNA CTD PMID:25629700 Agtr1a Rat formaldehyde increases expression ISO RGD:68977 6480464 Formaldehyde results in increased expression of AGTR1 mRNA CTD PMID:28937961 Agtr1a Rat formaldehyde increases expression ISO RGD:737190 6480464 Formaldehyde results in increased expression of AGTR1 protein CTD PMID:36706861 Agtr1a Rat formaldehyde multiple interactions ISO RGD:737190 6480464 Enalapril inhibits the reaction [Formaldehyde results in increased expression of AGTR1 protein] CTD PMID:36706861 Agtr1a Rat fructose multiple interactions EXP 6480464 APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGTR1A mRNA]; more ... CTD PMID:18360027|PMID:30710622 Agtr1a Rat fructose increases expression ISO RGD:68977 6480464 Fructose results in increased expression of AGTR1 mRNA CTD PMID:31655124 Agtr1a Rat fructose increases expression ISO RGD:737190 6480464 Fructose results in increased expression of AGTR1A mRNA CTD PMID:16843071 Agtr1a Rat fructose increases expression EXP 6480464 Fructose results in increased expression of AGTR1A mRNA CTD PMID:17587757|PMID:18360027|PMID:30710622 Agtr1a Rat fulvestrant multiple interactions ISO RGD:68977 6480464 [bisphenol A co-treated with Fulvestrant] results in increased methylation of AGTR1 gene CTD PMID:31601247 Agtr1a Rat gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of AGTR1A mRNA CTD PMID:33387578 Agtr1a Rat glucose multiple interactions ISO RGD:68977 6480464 Enalaprilat inhibits the reaction [Glucose results in increased expression of AGTR1 protein] CTD PMID:16452552 Agtr1a Rat glucose multiple interactions ISO RGD:737190 6480464 CEBPB protein inhibits the reaction [Glucose results in increased expression of AGTR1 protein] CTD PMID:29266779 Agtr1a Rat glucose increases expression ISO RGD:737190 6480464 Glucose results in increased expression of AGTR1 protein CTD PMID:29266779 Agtr1a Rat glucose increases expression ISO RGD:68977 6480464 Glucose results in increased expression of AGTR1 mRNA; Glucose results in increased expression of AGTR1 more ... CTD PMID:16452552|PMID:31655124|PMID:34464088 Agtr1a Rat glycochenodeoxycholic acid multiple interactions EXP 6480464 AGTR1 protein promotes the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased more ... CTD PMID:23300732 Agtr1a Rat glyoxylic acid increases expression EXP 6480464 glyoxylic acid results in increased expression of AGTR1 protein CTD PMID:37454925 Agtr1a Rat goralatide multiple interactions ISO RGD:737190 6480464 ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression more ... CTD PMID:33007385 Agtr1a Rat Heptachlor epoxide decreases expression ISO RGD:737190 6480464 Heptachlor Epoxide results in decreased expression of AGTR1A mRNA CTD PMID:25270620 Agtr1a Rat hexachlorobenzene increases expression EXP 6480464 Hexachlorobenzene results in increased expression of AGTR1 protein CTD PMID:29277037 Agtr1a Rat hydrochlorothiazide decreases expression EXP 6480464 Hydrochlorothiazide results in decreased expression of AGTR1A mRNA CTD PMID:18796534 Agtr1a Rat hydrogen peroxide multiple interactions ISO RGD:737190 6480464 Aspirin inhibits the reaction [Hydrogen Peroxide results in increased expression of AGTR1A mRNA]; Losartan inhibits more ... CTD PMID:22306536 Agtr1a Rat hydrogen peroxide multiple interactions ISO RGD:68977 6480464 epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression more ... CTD PMID:36162953 Agtr1a Rat hydrogen peroxide increases expression ISO RGD:68977 6480464 Hydrogen Peroxide results in increased expression of AGTR1 mRNA; Hydrogen Peroxide results in increased expression more ... CTD PMID:36162953 Agtr1a Rat hydrogen peroxide increases expression ISO RGD:737190 6480464 Hydrogen Peroxide results in increased expression of AGTR1A mRNA CTD PMID:22306536|PMID:30710622 Agtr1a Rat indole-3-methanol affects expression EXP 6480464 indole-3-carbinol affects the expression of AGTR1A mRNA CTD PMID:21396975 Agtr1a Rat indometacin multiple interactions ISO RGD:68977 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ... CTD PMID:28628672 Agtr1a Rat inulin multiple interactions ISO RGD:737190 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of AGTR1A mRNA CTD PMID:36331819 Agtr1a Rat irbesartan multiple interactions ISO RGD:737190 6480464 Cholesterol inhibits the reaction [irbesartan results in increased expression of AGTR1 mRNA] CTD PMID:19028402 Agtr1a Rat irbesartan multiple interactions ISO RGD:68977 6480464 irbesartan binds to and results in decreased activity of AGTR1 protein CTD PMID:12022239 Agtr1a Rat irbesartan affects response to substance ISO RGD:68977 6480464 AGTR1 gene polymorphism affects the susceptibility to irbesartan CTD PMID:11910301 Agtr1a Rat isoprenaline decreases expression ISO RGD:737190 6480464 Isoproterenol results in decreased expression of AGTR1A mRNA CTD PMID:17350036 Agtr1a Rat isotretinoin increases expression EXP 6480464 Isotretinoin results in increased expression of AGTR1 mRNA; Isotretinoin results in increased expression of AGTR1 more ... CTD PMID:19212007 Agtr1a Rat L-ethionine affects expression EXP 6480464 Ethionine affects the expression of AGTR1A mRNA CTD PMID:19483382 Agtr1a Rat lipoic acid multiple interactions ISO RGD:737190 6480464 Thioctic Acid affects the reaction [Dietary Fats affects the expression of AGTR1A mRNA] CTD PMID:27260466 Agtr1a Rat lipoic acid multiple interactions EXP 6480464 Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of AGTR1] CTD PMID:26518973 Agtr1a Rat lipopolysaccharide multiple interactions EXP 6480464 Edaravone inhibits the reaction [Lipopolysaccharides results in decreased expression of AGTR1A mRNA] CTD PMID:19118600 Agtr1a Rat lipopolysaccharide increases expression ISO RGD:68977 6480464 Lipopolysaccharides results in increased expression of AGTR1 mRNA CTD PMID:26862037 Agtr1a Rat lipopolysaccharide multiple interactions ISO RGD:68977 6480464 ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression more ... CTD PMID:26862037 Agtr1a Rat lipopolysaccharide decreases expression EXP 6480464 Lipopolysaccharides results in decreased expression of AGTR1A mRNA CTD PMID:19118600 Agtr1a Rat lithium chloride multiple interactions EXP 6480464 [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of AGTR1A more ... CTD PMID:32494933 Agtr1a Rat losartan decreases expression EXP 6480464 Losartan results in decreased expression of AGTR1 protein; Losartan results in decreased expression of AGTR1A more ... CTD PMID:18300857|PMID:18765277|PMID:28091615 Agtr1a Rat losartan increases expression EXP 6480464 Losartan results in increased expression of AGTR1 mRNA; Losartan results in increased expression of AGTR1A more ... CTD PMID:11893553|PMID:9533614 Agtr1a Rat losartan multiple interactions EXP 6480464 [Cilazapril co-treated with Losartan] promotes the reaction [Doxorubicin results in increased expression of AGTR1 mRNA]; more ... CTD PMID:12930639|PMID:15157388|PMID:15331931|PMID:15728788|PMID:15809360|PMID:18267125|PMID:18300857 Agtr1a Rat losartan decreases activity ISO RGD:68977 6480464 Losartan results in decreased activity of AGTR1 protein CTD PMID:9124547 Agtr1a Rat losartan multiple interactions ISO RGD:68977 6480464 [Losartan results in decreased activity of AGTR1 protein] which results in decreased abundance of Aldosterone; more ... CTD PMID:10821809|PMID:15807884|PMID:28578904|PMID:9124547 Agtr1a Rat losartan multiple interactions ISO RGD:737190 6480464 Losartan binds to and results in decreased activity of AGTR1A protein; Losartan inhibits the reaction more ... CTD PMID:15528393|PMID:22306536|PMID:25511041|PMID:28578904|PMID:33007385 Agtr1a Rat Magnolol multiple interactions EXP 6480464 magnolol inhibits the reaction [AGT protein binds to AGTR1A protein]; magnolol inhibits the reaction [Monocrotaline more ... CTD PMID:30466619 Agtr1a Rat mangiferin multiple interactions EXP 6480464 mangiferin inhibits the reaction [AGT protein results in increased expression of AGTR1A mRNA]; mangiferin inhibits more ... CTD PMID:17645561|PMID:19706694 Agtr1a Rat mechlorethamine multiple interactions EXP 6480464 Valproic Acid promotes the reaction [Mechlorethamine results in increased expression of AGTR1A mRNA] CTD PMID:28184907 Agtr1a Rat mechlorethamine increases expression EXP 6480464 Mechlorethamine results in increased expression of AGTR1A mRNA CTD PMID:28184907 Agtr1a Rat mercury dibromide increases expression ISO RGD:68977 6480464 mercuric bromide results in increased expression of AGTR1 mRNA CTD PMID:27188386 Agtr1a Rat mercury dichloride increases expression EXP 6480464 Mercuric Chloride results in increased expression of AGTR1A mRNA CTD PMID:28987480 Agtr1a Rat metformin multiple interactions ISO RGD:737190 6480464 Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of AGTR1A mRNA] CTD PMID:37120126 Agtr1a Rat methamphetamine increases expression EXP 6480464 Methamphetamine results in increased expression of AGTR1A protein CTD PMID:33421459 Agtr1a Rat mevinphos increases expression EXP 6480464 Mevinphos results in increased expression of AGTR1A mRNA; Mevinphos results in increased expression of AGTR1A more ... CTD PMID:23824088 Agtr1a Rat mevinphos multiple interactions EXP 6480464 [Mevinphos results in increased activity of AGTR1A protein] promotes the reaction [NOX1 protein results in more ... CTD PMID:23824088 Agtr1a Rat mifepristone multiple interactions EXP 6480464 Mifepristone inhibits the reaction [Corticosterone results in increased expression of AGTR1A mRNA] CTD PMID:30423288 Agtr1a Rat mono(2-ethylhexyl) phthalate multiple interactions ISO RGD:737190 6480464 [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in increased expression of AGTR1A mRNA CTD PMID:36189433 Agtr1a Rat monocrotaline increases expression EXP 6480464 Monocrotaline results in increased expression of AGTR1A protein CTD PMID:30466619 Agtr1a Rat monocrotaline multiple interactions EXP 6480464 magnolol inhibits the reaction [Monocrotaline results in increased expression of AGTR1A protein] CTD PMID:30466619 Agtr1a Rat N-acetyl-L-cysteine multiple interactions ISO RGD:737190 6480464 Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of AGTR1 mRNA] CTD PMID:23603059 Agtr1a Rat N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of AGTR1A mRNA CTD PMID:17602206 Agtr1a Rat N-nitrosodimethylamine decreases expression EXP 6480464 Dimethylnitrosamine results in decreased expression of AGTR1A mRNA CTD PMID:25380136 Agtr1a Rat Nandrolone decanoate increases expression EXP 6480464 nandrolone decanoate results in increased expression of AGTR1A mRNA CTD PMID:17906098 Agtr1a Rat nerolidol multiple interactions EXP 6480464 nerolidol inhibits the reaction [AGT protein results in increased expression of AGTR1A protein] CTD PMID:33212213 Agtr1a Rat nickel atom decreases expression ISO RGD:68977 6480464 Nickel results in decreased expression of AGTR1 mRNA CTD PMID:25583101 Agtr1a Rat nicotinamide multiple interactions EXP 6480464 [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [resveratrol results in decreased more ... CTD PMID:18420994 Agtr1a Rat nicotinamide multiple interactions ISO RGD:737190 6480464 2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of AGTR1A more ... CTD PMID:37120126 Agtr1a Rat nicotine increases expression EXP 6480464 Nicotine results in increased expression of AGTR1A protein CTD PMID:22691361 Agtr1a Rat nitrendipine affects response to substance ISO RGD:68977 6480464 AGTR1 gene SNP affects the susceptibility to Nitrendipine CTD PMID:8952600 Agtr1a Rat nitric oxide affects abundance EXP 6480464 AGTR1A protein affects the abundance of Nitric Oxide CTD PMID:19151255 Agtr1a Rat nitrofen decreases expression EXP 6480464 nitrofen results in decreased expression of AGTR1A mRNA CTD PMID:15578192|PMID:16292651 Agtr1a Rat nitrofen increases expression EXP 6480464 nitrofen results in increased expression of AGTR1A mRNA CTD PMID:33484710 Agtr1a Rat okadaic acid increases expression ISO RGD:68977 6480464 Okadaic Acid results in increased expression of AGTR1 mRNA CTD PMID:38832940 Agtr1a Rat olmesartan decreases activity ISO RGD:68977 6480464 olmesartan results in decreased activity of AGTR1 protein CTD PMID:17208988 Agtr1a Rat omeprazole affects expression EXP 6480464 Omeprazole affects the expression of AGTR1A mRNA CTD PMID:19483382 Agtr1a Rat ouabain decreases expression EXP 6480464 Ouabain results in decreased expression of AGTR1A protein CTD PMID:16565308 Agtr1a Rat ouabain affects expression EXP 6480464 Ouabain affects the expression of AGTR1A mRNA CTD PMID:16565308 Agtr1a Rat oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of AGTR1A mRNA CTD PMID:25729387 Agtr1a Rat ozone increases expression ISO RGD:737190 6480464 Ozone results in increased expression of AGTR1 protein CTD PMID:27679563 Agtr1a Rat ozone multiple interactions ISO RGD:737190 6480464 [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased more ... CTD PMID:34911549 Agtr1a Rat ozone increases expression EXP 6480464 Ozone results in increased expression of AGTR1 mRNA CTD PMID:26667334 Agtr1a Rat paracetamol decreases expression ISO RGD:737190 6480464 Acetaminophen results in decreased expression of AGTR1A mRNA CTD PMID:11752693 Agtr1a Rat paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of AGTR1A mRNA CTD PMID:33387578 Agtr1a Rat paracetamol decreases expression ISO RGD:68977 6480464 Acetaminophen results in decreased expression of AGTR1 mRNA CTD PMID:21420995|PMID:22230336 Agtr1a Rat paraquat increases expression ISO RGD:68977 6480464 Paraquat results in increased expression of AGTR1 mRNA; Paraquat results in increased expression of AGTR1 more ... CTD PMID:20035857 Agtr1a Rat PCB138 multiple interactions ISO RGD:737190 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Agtr1a Rat pentanal decreases expression ISO RGD:68977 6480464 pentanal results in decreased expression of AGTR1 mRNA CTD PMID:26079696 Agtr1a Rat perfluorooctane-1-sulfonic acid decreases expression EXP 6480464 perfluorooctane sulfonic acid results in decreased expression of AGTR1A mRNA CTD PMID:19162173 Agtr1a Rat perfluorooctane-1-sulfonic acid multiple interactions ISO RGD:737190 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of AGTR1A mRNA; [perfluorooctane sulfonic more ... CTD PMID:36331819 Agtr1a Rat perfluorooctanoic acid decreases expression EXP 6480464 perfluorooctanoic acid results in decreased expression of AGTR1A mRNA CTD PMID:19162173 Agtr1a Rat perindopril multiple interactions EXP 6480464 Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of AGTR1A mRNA]; Perindopril inhibits more ... CTD PMID:12930639|PMID:16097048 Agtr1a Rat perindopril multiple interactions ISO RGD:737190 6480464 [Perindopril co-treated with AM6545] inhibits the reaction [Streptozocin results in increased expression of AGTR1A protein]; more ... CTD PMID:30184259 Agtr1a Rat perindopril affects response to substance ISO RGD:68977 6480464 AGTR1 gene SNP affects the susceptibility to Perindopril CTD PMID:8952600 Agtr1a Rat phenylarsine oxide multiple interactions EXP 6480464 oxophenylarsine inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A more ... CTD PMID:18267125 Agtr1a Rat phosphane increases expression EXP 6480464 phosphine results in increased expression of AGTR1 mRNA CTD PMID:34427094 Agtr1a Rat picrotoxin increases expression EXP 6480464 Picrotoxin results in increased expression of AGTR1A mRNA CTD PMID:15170462 Agtr1a Rat pioglitazone multiple interactions ISO RGD:737190 6480464 [N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of AGTR1A mRNA CTD PMID:27935865 Agtr1a Rat pirfenidone decreases expression EXP 6480464 pirfenidone results in decreased expression of AGTR1 protein CTD PMID:28091615 Agtr1a Rat pirinixic acid decreases expression ISO RGD:737190 6480464 pirinixic acid results in decreased expression of AGTR1A mRNA CTD PMID:25270620 Agtr1a Rat pirinixic acid affects expression EXP 6480464 pirinixic acid affects the expression of AGTR1A mRNA CTD PMID:19483382 Agtr1a Rat pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of AGTR1A mRNA; pirinixic acid results in decreased expression more ... CTD PMID:18300857|PMID:19162173 Agtr1a Rat potassium chromate decreases expression ISO RGD:68977 6480464 potassium chromate(VI) results in decreased expression of AGTR1 mRNA CTD PMID:22079256 Agtr1a Rat potassium chromate increases expression ISO RGD:68977 6480464 potassium chromate(VI) results in increased expression of AGTR1 mRNA CTD PMID:22714537 Agtr1a Rat potassium chromate multiple interactions ISO RGD:68977 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of AGTR1 mRNA CTD PMID:22079256 Agtr1a Rat pregabalin increases expression EXP 6480464 Pregabalin results in increased expression of AGTR1 protein CTD PMID:31629013 Agtr1a Rat pregabalin multiple interactions EXP 6480464 Captopril inhibits the reaction [Pregabalin results in increased expression of AGTR1 protein]; Telmisartan inhibits the more ... CTD PMID:31629013 Agtr1a Rat propanal decreases expression ISO RGD:68977 6480464 propionaldehyde results in decreased expression of AGTR1 mRNA CTD PMID:26079696 Agtr1a Rat Ptaquiloside decreases expression ISO RGD:737190 6480464 ptaquiloside results in decreased expression of AGTR1A mRNA CTD PMID:23274088 Agtr1a Rat quercetin decreases expression EXP 6480464 Quercetin results in decreased expression of AGTR1A mRNA CTD PMID:18356687 Agtr1a Rat quercetin decreases expression ISO RGD:68977 6480464 Quercetin results in decreased expression of AGTR1 mRNA CTD PMID:21632981 Agtr1a Rat quercetin multiple interactions ISO RGD:737190 6480464 Quercetin affects the reaction [Dietary Fats affects the expression of AGTR1A mRNA] CTD PMID:27260466 Agtr1a Rat ramipril multiple interactions EXP 6480464 Ramipril inhibits the reaction [Doxorubicin results in increased expression of AGTR1A mRNA] CTD PMID:36636964 Agtr1a Rat reactive oxygen species multiple interactions ISO RGD:737190 6480464 [AGT protein modified form co-treated with AGTR1A co-treated with AGTR1B] results in increased abundance of more ... CTD PMID:17620961 Agtr1a Rat rebaudioside A increases expression ISO RGD:68977 6480464 rebaudioside A results in increased expression of AGTR1 mRNA CTD PMID:31655124 Agtr1a Rat resveratrol multiple interactions EXP 6480464 [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [resveratrol results in decreased more ... CTD PMID:18420994 Agtr1a Rat resveratrol decreases expression EXP 401793709 resveratrol decreases expression of mRNA in kidney of male offspring from pregnant dams treated with more ... RGD Agtr1a Rat resveratrol decreases expression ISO RGD:737190 6480464 resveratrol results in decreased expression of AGTR1 protein CTD PMID:18420994 Agtr1a Rat resveratrol decreases expression EXP 6480464 resveratrol results in decreased expression of AGTR1 mRNA; resveratrol results in decreased expression of AGTR1 more ... CTD PMID:18420994 Agtr1a Rat resveratrol multiple interactions ISO RGD:737190 6480464 resveratrol affects the reaction [Dietary Fats affects the expression of AGTR1A mRNA] CTD PMID:27260466 Agtr1a Rat rotenone increases expression ISO RGD:737190 6480464 Rotenone results in increased expression of AGTR1A mRNA CTD PMID:29665408 Agtr1a Rat rotenone decreases expression ISO RGD:737190 6480464 Rotenone results in decreased expression of AGTR1A mRNA CTD PMID:35919817 Agtr1a Rat silicon dioxide decreases expression ISO RGD:68977 6480464 Silicon Dioxide analog results in decreased expression of AGTR1 mRNA CTD PMID:25895662 Agtr1a Rat silicon dioxide multiple interactions ISO RGD:737190 6480464 7-Ala-angiotensin (1-7) promotes the reaction [Silicon Dioxide results in increased expression of AGTR1 protein]; ACE more ... CTD PMID:33007385 Agtr1a Rat silicon dioxide increases expression ISO RGD:737190 6480464 Silicon Dioxide results in increased expression of AGTR1 protein CTD PMID:33007385 Agtr1a Rat simvastatin decreases expression ISO RGD:68977 6480464 Simvastatin results in decreased expression of AGTR1 mRNA CTD PMID:17513949|PMID:18475152 Agtr1a Rat sodium arsenite decreases expression ISO RGD:737190 6480464 sodium arsenite results in decreased expression of AGTR1A mRNA CTD PMID:25270620 Agtr1a Rat sodium arsenite increases expression ISO RGD:68977 6480464 sodium arsenite results in increased expression of AGTR1 mRNA; sodium arsenite results in increased expression more ... CTD PMID:22714537|PMID:28973481 Agtr1a Rat sodium arsenite increases expression ISO RGD:737190 6480464 sodium arsenite results in increased expression of AGTR1 mRNA alternative form CTD PMID:23603059 Agtr1a Rat sodium arsenite multiple interactions ISO RGD:68977 6480464 ERN1 affects the reaction [sodium arsenite results in increased expression of AGTR1 mRNA]; HIF1A affects more ... CTD PMID:28973481 Agtr1a Rat sodium arsenite multiple interactions ISO RGD:737190 6480464 Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of AGTR1 mRNA]; pyrazolanthrone inhibits more ... CTD PMID:23603059 Agtr1a Rat sodium fluoride increases expression EXP 6480464 Sodium Fluoride results in increased expression of AGTR1A mRNA; Sodium Fluoride results in increased expression more ... CTD PMID:37105417 Agtr1a Rat spironolactone decreases expression EXP 6480464 Spironolactone results in decreased expression of AGTR1 protein CTD PMID:18586661|PMID:19114643 Agtr1a Rat steviol increases expression ISO RGD:68977 6480464 steviol results in increased expression of AGTR1 mRNA CTD PMID:31655124 Agtr1a Rat stevioside increases expression ISO RGD:68977 6480464 stevioside results in increased expression of AGTR1 mRNA CTD PMID:31655124 Agtr1a Rat streptozocin multiple interactions ISO RGD:737190 6480464 2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of AGTR1A more ... CTD PMID:21381899|PMID:29266779|PMID:30184259|PMID:37120126 Agtr1a Rat streptozocin multiple interactions EXP 6480464 [Streptozocin co-treated with Dietary Fats] results in increased expression of AGTR1A mRNA; esculetin inhibits the more ... CTD PMID:28946194 Agtr1a Rat streptozocin increases expression ISO RGD:737190 6480464 Streptozocin results in increased expression of AGTR1 protein; Streptozocin results in increased expression of AGTR1A more ... CTD PMID:17724226|PMID:18487452|PMID:21381899|PMID:29266779|PMID:30184259 Agtr1a Rat sucrose multiple interactions EXP 6480464 Sucrose inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A more ... CTD PMID:18267125 Agtr1a Rat superoxide multiple interactions EXP 6480464 [Mevinphos results in increased activity of AGTR1A protein] promotes the reaction [NOX1 protein results in more ... CTD PMID:23824088 Agtr1a Rat telmisartan decreases expression EXP 6480464 telmisartan results in decreased expression of AGTR1A mRNA CTD PMID:19171132 Agtr1a Rat telmisartan decreases expression EXP 329956421 telmisartan decreases expression of mRNA in mandible of rats with periodontal disease RGD Agtr1a Rat telmisartan multiple interactions ISO RGD:68977 6480464 telmisartan binds to and results in decreased activity of AGTR1 protein CTD PMID:21557540 Agtr1a Rat telmisartan multiple interactions EXP 6480464 Telmisartan binds to and results in decreased activity of AGTR1 protein; Telmisartan inhibits the reaction more ... CTD PMID:19706694|PMID:20888384|PMID:31629013|PMID:9728324 Agtr1a Rat telmisartan increases expression EXP 6480464 telmisartan results in increased expression of AGTR1 mRNA CTD PMID:9533614 Agtr1a Rat telmisartan affects binding EXP 6480464 telmisartan binds to AGTR1 protein CTD PMID:8220885 Agtr1a Rat telmisartan multiple interactions ISO RGD:737190 6480464 telmisartan inhibits the reaction [[AGT protein modified form co-treated with AGTR1A co-treated with AGTR1B] results more ... CTD PMID:17620961|PMID:21381899 Agtr1a Rat testosterone increases expression ISO RGD:737190 6480464 Testosterone results in increased expression of AGTR1 mRNA CTD PMID:22539767 Agtr1a Rat testosterone decreases expression ISO RGD:737190 6480464 Testosterone deficiency results in decreased expression of AGTR1A mRNA CTD PMID:33848595 Agtr1a Rat testosterone multiple interactions ISO RGD:737190 6480464 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane inhibits the reaction [Testosterone deficiency results in decreased expression of AGTR1A mRNA] CTD PMID:33848595 Agtr1a Rat testosterone affects response to substance ISO RGD:737190 6480464 AGTR1 protein affects the susceptibility to Testosterone CTD PMID:22539767 Agtr1a Rat tetrachloromethane multiple interactions ISO RGD:737190 6480464 AGTR1A protein affects the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; AGTR1A more ... CTD PMID:12890498 Agtr1a Rat tetrachloromethane multiple interactions EXP 6480464 Losartan inhibits the reaction [Carbon Tetrachloride results in increased expression of AGTR1A mRNA]; Losartan inhibits more ... CTD PMID:12930639|PMID:16097048 Agtr1a Rat tetrachloromethane decreases expression ISO RGD:737190 6480464 Carbon Tetrachloride results in decreased expression of AGTR1A mRNA CTD PMID:27339419|PMID:31919559 Agtr1a Rat tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of AGTR1A mRNA; Carbon Tetrachloride results in increased expression more ... CTD PMID:12930639|PMID:16097048 Agtr1a Rat tetraphene increases expression ISO RGD:737190 6480464 benz(a)anthracene results in increased expression of AGTR1A mRNA CTD PMID:26377693 Agtr1a Rat thioacetamide affects expression EXP 6480464 Thioacetamide affects the expression of AGTR1A mRNA CTD PMID:19483382 Agtr1a Rat titanium dioxide decreases expression ISO RGD:737190 6480464 titanium dioxide results in decreased expression of AGTR1A mRNA CTD PMID:19464567|PMID:23557971 Agtr1a Rat topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of AGTR1A mRNA CTD PMID:25729387 Agtr1a Rat tremolite asbestos decreases expression ISO RGD:737190 6480464 tremolite results in decreased expression of AGTR1A mRNA CTD PMID:29279043 Agtr1a Rat triadimefon decreases expression EXP 6480464 triadimefon results in decreased expression of AGTR1 mRNA; triadimefon results in decreased expression of AGTR1 more ... CTD PMID:34508824 Agtr1a Rat tributylstannane increases expression EXP 6480464 tributyltin results in increased expression of AGTR1A protein CTD PMID:30172001 Agtr1a Rat trimellitic anhydride decreases expression ISO RGD:737190 6480464 trimellitic anhydride results in decreased expression of AGTR1A mRNA CTD PMID:19042947 Agtr1a Rat triphenyl phosphate decreases expression EXP 6480464 triphenyl phosphate results in decreased expression of AGTR1A mRNA CTD PMID:30589522 Agtr1a Rat triphenylstannane increases expression EXP 6480464 triphenyltin results in increased expression of AGTR1 mRNA; triphenyltin results in increased expression of AGTR1 more ... CTD PMID:31765896 Agtr1a Rat troglitazone decreases expression ISO RGD:737190 6480464 troglitazone results in decreased expression of AGTR1 mRNA CTD PMID:28973697 Agtr1a Rat tryptophan increases expression EXP 401793718 tryptophan in pregnant dams increases expression of mRNA in kidney of male offspring RGD Agtr1a Rat valproic acid multiple interactions EXP 6480464 Valproic Acid promotes the reaction [Mechlorethamine results in increased expression of AGTR1A mRNA] CTD PMID:28184907 Agtr1a Rat valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of AGTR1A mRNA CTD PMID:29427782 Agtr1a Rat valproic acid increases expression ISO RGD:68977 6480464 Valproic Acid results in increased expression of AGTR1 mRNA CTD PMID:28001369|PMID:29154799 Agtr1a Rat valproic acid affects expression ISO RGD:68977 6480464 Valproic Acid affects the expression of AGTR1 mRNA CTD PMID:25979313 Agtr1a Rat valsartan decreases expression EXP 6480464 Valsartan results in decreased expression of AGTR1A mRNA CTD PMID:18403896 Agtr1a Rat valsartan multiple interactions ISO RGD:737190 6480464 Valsartan promotes the reaction [Streptozocin results in increased expression of AGTR1 protein] CTD PMID:29266779 Agtr1a Rat valsartan multiple interactions ISO RGD:68977 6480464 Valsartan binds to and results in decreased activity of AGTR1 protein CTD PMID:28973481 Agtr1a Rat vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of AGTR1A mRNA CTD PMID:23034163 Agtr1a Rat warfarin multiple interactions ISO RGD:68977 6480464 epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression more ... CTD PMID:36162953 Agtr1a Rat zinc oxide decreases expression ISO RGD:68977 6480464 Zinc Oxide analog results in decreased expression of AGTR1 mRNA CTD PMID:27185063
Molecular Function
Only show annotations with direct experimental evidence (0 objects hidden)
Agtr1a Rat angiotensin type I receptor activity IDA 70819 RGD Agtr1a Rat angiotensin type I receptor activity enables ISO RGD:737190 1624291 PMID:12657564 RGD PMID:12657564 Agtr1a Rat angiotensin type I receptor activity enables IBA MGI:87964|PANTHER:PTN002796070|RGD:2070|UniProtKB:P25104|UniProtKB:P30555|UniProtKB:P30556|UniProtKB:P43240 1600115 GO_REF:0000033 GO_Central GO_REF:0000033 Agtr1a Rat angiotensin type I receptor activity enables IEA UniProtKB:P29754|ensembl:ENSMUSP00000070958 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 Agtr1a Rat angiotensin type I receptor activity enables ISO RGD:12233622 1624291 PMID:8168620 RGD PMID:8168620 Agtr1a Rat angiotensin type I receptor activity enables ISO RGD:14056432 1624291 PMID:8491254 RGD PMID:8491254 Agtr1a Rat angiotensin type I receptor activity enables IDA 152025523 PMID:2041570 UniProt Agtr1a Rat angiotensin type I receptor activity enables IDA 152025503 PMID:10747880 UniProt Agtr1a Rat angiotensin type I receptor activity enables ISO RGD:68977 1624291 UniProtKB:P01019 PMID:10993080, PMID:1378723, PMID:15611106, PMID:25913193, PMID:26420482, PMID:30639100, PMID:32079768, PMID:8987975 RGD PMID:10993080|PMID:1378723|PMID:15611106|PMID:25913193|PMID:26420482|PMID:30639100|PMID:32079768|PMID:8987975 Agtr1a Rat angiotensin type II receptor activity enables ISO RGD:68977 1624291 PMID:1567413 RGD PMID:1567413 Agtr1a Rat angiotensin type II receptor activity enables IEA InterPro:IPR000190 1600115 GO_REF:0000002 InterPro GO_REF:0000002 Agtr1a Rat bradykinin receptor binding enables ISO RGD:68977 1624291 UniProtKB:P30411 PMID:10993080 RGD PMID:10993080 Agtr1a Rat D1 dopamine receptor binding IPI RGD:2518 7248445 RGD Agtr1a Rat G protein-coupled receptor activity enables IEA UniProtKB-KW:KW-0297 1600115 GO_REF:0000043 UniProt GO_REF:0000043 Agtr1a Rat G protein-coupled receptor activity enables IEA InterPro:IPR000276 1600115 GO_REF:0000002 InterPro GO_REF:0000002 Agtr1a Rat protein binding IPI RGD:2521 1581469 RGD Agtr1a Rat protein binding enables ISO RGD:737190 1624291 UniProtKB:Q9WVK0 PMID:10358057 RGD PMID:10358057 Agtr1a Rat protein binding enables ISO RGD:68977 1624291 UniProtKB:O75937|UniProtKB:P01019|UniProtKB:P01019-PRO_0000032458|UniProtKB:P05026|UniProtKB:P21333|UniProtKB:P32121|UniProtKB:P35414|UniProtKB:P41495|UniProtKB:P45880|UniProtKB:P49407|UniProtKB:P54368|UniProtKB:Q13956|UniProtKB:Q6ZMG9|UniProtKB:Q86TI2-2|UniProtKB:Q8N7X4 PMID:1378723, PMID:15611106, PMID:19023134, PMID:21412239, PMID:22935142, PMID:23597562, PMID:25416956, PMID:26460884, PMID:28298427, PMID:32814053 RGD PMID:1378723|PMID:15611106|PMID:19023134|PMID:21412239|PMID:22935142|PMID:23597562|PMID:25416956|PMID:26460884|PMID:28298427|PMID:32814053 Agtr1a Rat protein binding enables IPI UniProtKB:P01019 8553626 PMID:18202720 IntAct Agtr1a Rat protein binding enables IPI UniProtKB:P21333 10680029 PMID:26460884 UniProt Agtr1a Rat protein binding enables IPI UniProtKB:P30994 8554388 PMID:19023134 UniProt Agtr1a Rat protein binding IPI RGD:1310385 2316188 RGD Agtr1a Rat protein binding IPI RGD:620574 5129173 RGD Agtr1a Rat protein binding IPI RGD:2157 5509965 RGD Agtr1a Rat protein heterodimerization activity enables ISO RGD:68977 1624291 UniProtKB:P30411 PMID:10993080 RGD PMID:10993080 Agtr1a Rat protein kinase binding IPI RGD:2939 6478796 RGD Agtr1a Rat protein kinase binding IPI RGD:2939 5133683 RGD Agtr1a Rat protein kinase binding IPI RGD:2320469 6478796 RGD
Imported Annotations - SMPDB
Imported Annotations - KEGG (archival)
abdominal aortic aneurysm (ISO) aceruloplasminemia (ISO) AIDS-Associated Nephropathy (ISO) Alveolar Bone Loss (IEP) Alzheimer's disease (ISO) anti-basement membrane glomerulonephritis (IEP) asthma (IMP,ISO) atrial fibrillation (ISO) breast cancer (ISO) breast lobular carcinoma (ISO) Cardiac Arrhythmias (ISO) Cardiomegaly (IEP,IMP,ISO) carotid artery disease (ISO) Carotid Artery Injuries (IEP) cerebrovascular disease (ISO) Chronic Intermittent Hypoxia (IEP) chronic kidney disease (IMP,ISO) congestive heart failure (IMP,ISO) corneal neovascularization (ISO) coronary artery disease (ISO) Coronary Disease (ISO) COVID-19 (ISO) Diabetic Nephropathies (IMP,ISO) diabetic retinopathy (ISO) Diaphragmatic Hernia (ISO) diffuse cystic renal dysplasia (ISO) dilated cardiomyopathy (IEP,IMP) Ductal Carcinoma (ISO) essential hypertension (ISO) Experimental Liver Cirrhosis (ISO) Experimental Mammary Neoplasms (IEP,ISO) Experimental Radiation Injuries (IMP) Fetal Growth Retardation (IEP) Fibrosis (IMP,ISO) focal segmental glomerulosclerosis (IEP) Friedreich ataxia (ISO) genetic disease (ISO) glomerulosclerosis (IEP) glucose intolerance (ISO) glycogen storage disease XV (ISO) Huntington's disease (ISO) hyperinsulinism (IEP) hypertension (IEP,IMP,ISO) Hypertensive Nephropathy (IMP) IgA glomerulonephritis (ISO) Inflammation (ISO) intermediate coronary syndrome (ISO) kidney disease (ISO) Left Ventricular Hypertrophy (ISO) limb ischemia (ISO) lung disease (ISO) Metabolic Syndrome (ISO) myocardial infarction (IEP,ISO) Myocardial Reperfusion Injury (IEP) Neoplasm Metastasis (ISO) nephritis (IMP) pancreatic ductal carcinoma (ISO) Parkinson's disease (ISO) patent ductus arteriosus (ISO) Pituitary Neoplasms (ISO) placental insufficiency (IEP) Postoperative Cognitive Dysfunction (IEP) Prenatal Exposure Delayed Effects (IEP) proteinuria (IMP,ISO) pulmonary fibrosis (ISO) pulmonary hypertension (ISO) renal cell carcinoma (ISO) renal hypertension (IEP) Renal Tubular Dysgenesis (ISO) renovascular hypertension (IEP,IMP) sarcoidosis (ISO) Spontaneous Abortions (ISO) Vascular System Injuries (ISO) Ventricular Remodeling (IEP) vesicoureteral reflux (ISO)
(+)-pilocarpine (EXP) (-)-epigallocatechin 3-gallate (ISO) (1->4)-beta-D-glucan (ISO) (R)-lipoic acid (EXP,ISO) (S)-nicotine (EXP) 1,1-dichloroethene (ISO) 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO) 1,2-dimethylhydrazine (ISO) 1-naphthyl isothiocyanate (EXP,ISO) 1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine (ISO) 17alpha-ethynylestradiol (EXP) 17beta-estradiol (EXP,ISO) 2,2',4,4',5,5'-hexachlorobiphenyl (ISO) 2,2',5,5'-tetrachlorobiphenyl (ISO) 2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO) 2,4,4'-trichlorobiphenyl (ISO) 2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO) 2,5-dihydroxybenzoic acid (ISO) 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine (ISO) 2-butoxyethanol (ISO) 2-palmitoylglycerol (ISO) 3,3',4,4',5-pentachlorobiphenyl (ISO) 3,3',4,4'-tetrachlorobiphenyl (ISO) 3-isobutyl-1-methyl-7H-xanthine (ISO) 3H-1,2-dithiole-3-thione (EXP) 4,4'-diaminodiphenylmethane (EXP) 4,4'-sulfonyldiphenol (ISO) 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile (EXP) 4-hydroxy-TEMPO (ISO) 4-hydroxyphenyl retinamide (ISO) 5-aza-2'-deoxycytidine (EXP) 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole (EXP) 6-propyl-2-thiouracil (EXP) 7,9-dihydro-1H-purine-2,6,8(3H)-trione (ISO) 8-Br-cAMP (ISO) Ac-Ser-Asp-Lys-Pro-OH (ISO) acetylsalicylic acid (ISO) aflatoxin B1 (ISO) aldehydo-D-glucose (ISO) aldosterone (EXP,ISO) all-trans-retinoic acid (ISO) AM6545 (ISO) amiodarone (EXP) amlodipine (EXP) anthra[1,9-cd]pyrazol-6(2H)-one (ISO) antirheumatic drug (ISO) Aroclor 1254 (ISO) arsenite(3-) (ISO) arsenous acid (ISO) asbestos (ISO) aspartame (ISO) ATP (EXP) benazepril (EXP,ISO) benzbromarone (EXP) benzo[a]pyrene (ISO) beta-hexachlorocyclohexane (ISO) bis(2-ethylhexyl) phthalate (ISO) bisphenol A (EXP,ISO) bleomycin A2 (EXP) butanal (ISO) cadmium dichloride (ISO) caffeine (EXP) calcium atom (EXP) calcium(0) (EXP) candesartan (EXP,ISO) Candesartan cilexetil (EXP) capsaicin (EXP) captopril (EXP,ISO) CGP 52608 (ISO) chlordecone (ISO) chlorpyrifos (ISO) cholesterol (ISO) chromium(6+) (ISO) cilazapril monohydrate (EXP) clofibrate (EXP) clofibric acid (EXP) cobalt dichloride (ISO) corticosterone (EXP) cyclosporin A (EXP,ISO) D-glucose (ISO) daunorubicin (EXP) decabromodiphenyl ether (EXP) dexamethasone (EXP,ISO) diarsenic trioxide (ISO) dibenz[a,h]anthracene (ISO) dibutyl phthalate (ISO) diisononyl phthalate (ISO) diminazene diaceturate (ISO) dioxygen (EXP,ISO) dipentyl phthalate (EXP) diuron (EXP) doxorubicin (EXP) EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (EXP) edaravone (EXP) ellagic acid (EXP) enalapril (EXP,ISO) enalaprilat dihydrate (ISO) endosulfan (EXP) esculetin (EXP) estriol (ISO) ethanol (EXP) flavonoids (EXP) folic acid (EXP,ISO) formaldehyde (ISO) fructose (EXP,ISO) fulvestrant (ISO) gentamycin (EXP) glucose (ISO) glycochenodeoxycholic acid (EXP) glyoxylic acid (EXP) goralatide (ISO) Heptachlor epoxide (ISO) hexachlorobenzene (EXP) hydrochlorothiazide (EXP) hydrogen peroxide (ISO) indole-3-methanol (EXP) indometacin (ISO) inulin (ISO) irbesartan (ISO) isoprenaline (ISO) isotretinoin (EXP) L-ethionine (EXP) lipoic acid (EXP,ISO) lipopolysaccharide (EXP,ISO) lithium chloride (EXP) losartan (EXP,ISO) Magnolol (EXP) mangiferin (EXP) mechlorethamine (EXP) mercury dibromide (ISO) mercury dichloride (EXP) metformin (ISO) methamphetamine (EXP) mevinphos (EXP) mifepristone (EXP) mono(2-ethylhexyl) phthalate (ISO) monocrotaline (EXP) N-acetyl-L-cysteine (ISO) N-nitrosodiethylamine (EXP) N-nitrosodimethylamine (EXP) Nandrolone decanoate (EXP) nerolidol (EXP) nickel atom (ISO) nicotinamide (EXP,ISO) nicotine (EXP) nitrendipine (ISO) nitric oxide (EXP) nitrofen (EXP) okadaic acid (ISO) olmesartan (ISO) omeprazole (EXP) ouabain (EXP) oxaliplatin (EXP) ozone (EXP,ISO) paracetamol (EXP,ISO) paraquat (ISO) PCB138 (ISO) pentanal (ISO) perfluorooctane-1-sulfonic acid (EXP,ISO) perfluorooctanoic acid (EXP) perindopril (EXP,ISO) phenylarsine oxide (EXP) phosphane (EXP) picrotoxin (EXP) pioglitazone (ISO) pirfenidone (EXP) pirinixic acid (EXP,ISO) potassium chromate (ISO) pregabalin (EXP) propanal (ISO) Ptaquiloside (ISO) quercetin (EXP,ISO) ramipril (EXP) reactive oxygen species (ISO) rebaudioside A (ISO) resveratrol (EXP,ISO) rotenone (ISO) silicon dioxide (ISO) simvastatin (ISO) sodium arsenite (ISO) sodium fluoride (EXP) spironolactone (EXP) steviol (ISO) stevioside (ISO) streptozocin (EXP,ISO) sucrose (EXP) superoxide (EXP) telmisartan (EXP,ISO) testosterone (ISO) tetrachloromethane (EXP,ISO) tetraphene (ISO) thioacetamide (EXP) titanium dioxide (ISO) topotecan (EXP) tremolite asbestos (ISO) triadimefon (EXP) tributylstannane (EXP) trimellitic anhydride (ISO) triphenyl phosphate (EXP) triphenylstannane (EXP) troglitazone (ISO) tryptophan (EXP) valproic acid (EXP,ISO) valsartan (EXP,ISO) vinclozolin (EXP) warfarin (ISO) zinc oxide (ISO)
Biological Process
activation of Janus kinase activity (IMP) angiotensin-activated signaling pathway (IMP,ISO) blood vessel development (IEA,ISO) brain renin-angiotensin system (IEA,ISO) calcium-mediated signaling (ISO) cell chemotaxis (ISO) cellular response to dexamethasone stimulus (IDA) dopamine biosynthetic process (IMP) drinking behavior (IEA,IMP,ISO) G protein-coupled receptor signaling pathway (IBA,IEA,IMP,ISO) gene expression (IEA,ISO) heart development (IEA,ISO) inflammatory response (IBA,IEA,ISO) kidney development (IEA,ISO) maintenance of blood vessel diameter homeostasis by renin-angiotensin (ISO,ISS) negative regulation of neuron apoptotic process (ISO) negative regulation of smooth muscle cell apoptotic process (IEA,ISO) neuron apoptotic process (IEA,ISO) phospholipase C-activating angiotensin-activated signaling pathway (ISO) phospholipase C-activating G protein-coupled receptor signaling pathway (IDA,ISO) positive regulation of angiogenesis (IMP) positive regulation of blood pressure (IEA,IMP,ISO) positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis (ISO) positive regulation of branching involved in ureteric bud morphogenesis (IMP) positive regulation of calcium ion import across plasma membrane (IMP) positive regulation of cell population proliferation (IMP) positive regulation of cholesterol metabolic process (ISO) positive regulation of cytokine production (IEA,ISO) positive regulation of cytosolic calcium ion concentration (IBA,ISO) positive regulation of macrophage derived foam cell differentiation (ISO) positive regulation of receptor recycling (IDA) positive regulation of superoxide anion generation (IMP) positive regulation of vascular associated smooth muscle cell proliferation (IEA,ISO) regulation of blood pressure (IEA,ISO) regulation of pH (IDA) regulation of renal output by angiotensin (IEA,ISO) regulation of systemic arterial blood pressure by circulatory renin-angiotensin (IEA,ISO) regulation of vascular associated smooth muscle cell apoptotic process (IEA,ISO) regulation of vasoconstriction (IEA,ISO) renin secretion into blood stream (IEA,ISO) renin-angiotensin regulation of aldosterone production (IEA,IMP,ISO) response to activity (IEP) response to angiotensin (IEP) response to corticosterone (IEP) response to estrogen (IDA,IEP) response to salt stress (IEP) Rho protein signal transduction (ISO) signal transduction (IEA) vascular associated smooth muscle cell proliferation (IEA,ISO) vasoconstriction (IMP)
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31.
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34.
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Angiotensin-II type 1 receptor-mediated Janus kinase 2 activation induces liver fibrosis.
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OMIM Disease Annotation Pipeline
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87.
Reduction of cold-induced hypertension by antisense oligodeoxynucleotides to angiotensinogen mRNA and AT1-receptor mRNA in brain and blood.
Peng JF, etal., Hypertension. 1998 Jun;31(6):1317-23.
88.
KEGG Annotation Import Pipeline
Pipeline to import KEGG annotations from KEGG into RGD
89.
SMPDB Annotation Import Pipeline
Pipeline to import SMPDB annotations from SMPDB into RGD
90.
The luminal membrane of rat thick limb expresses AT1 receptor and aminopeptidase activities.
Poumarat JS, etal., Kidney Int. 2002 Aug;62(2):434-45.
91.
Renin-angiotensin polymorphisms and QTc interval prolongation in end-stage renal disease.
Raizada V, etal., Kidney Int. 2005 Sep;68(3):1186-9.
92.
Angiotensin III: a central regulator of vasopressin release and blood pressure.
Reaux A, etal., Trends Endocrinol Metab. 2001 May-Jun;12(4):157-62.
93.
GOA pipeline
RGD automated data pipeline
94.
ClinVar Automated Import and Annotation Pipeline
RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
95.
Data Import for Chemical-Gene Interactions
RGD automated import pipeline for gene-chemical interactions
96.
AT-1 receptor and phospholipase C are involved in angiotensin III modulation of hypothalamic noradrenergic transmission.
Rodriguez-Campos M, etal., Cell Mol Neurobiol. 2000 Dec;20(6):747-62.
97.
Hyperinsulinemia: effect on cardiac mass/function, angiotensin II receptor expression, and insulin signaling pathways.
Samuelsson AM, etal., Am J Physiol Heart Circ Physiol. 2006 Aug;291(2):H787-96. Epub 2006 Mar 24.
98.
Evidence for the importance of angiotensin II type 1 receptor in ischemia-induced angiogenesis.
Sasaki K, etal., J Clin Invest 2002 Mar;109(5):603-11.
99.
Dietary salt intake modulates angiotensin II type 1 receptor gene expression.
Schmid C, etal., Hypertension. 1997 Apr;29(4):923-9.
100.
[Effects of long-term antihypertensive therapy with losartan on blood pressure and cognitive function in patients with essential hypertension and other cerebrovascular risk factors (AWARE observational study)].
Schrader J, etal., Med Klin (Munich). 2008 Jul 15;103(7):491-9. doi: 10.1007/s00063-008-1073-4.
101.
Angiotensin-II type 1 receptor and NOX2 mediate TCF/LEF and CREB dependent WISP1 induction and cardiomyocyte hypertrophy.
Shanmugam P, etal., J Mol Cell Cardiol. 2011 Mar 2.
102.
Effects of dexamethasone exposure on rat metanephric development: in vitro and in vivo studies.
Singh RR, etal., Am J Physiol Renal Physiol. 2007 Aug;293(2):F548-54. Epub 2007 May 30.
103.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
104.
Transcriptional suppression of type 1 angiotensin II receptor gene expression by peroxisome proliferator-activated receptor-gamma in vascular smooth muscle cells.
Sugawara A, etal., Endocrinology 2001 Jul;142(7):3125-34.
105.
Salt-induced renal injury in SHRs is mediated by AT1 receptor activation.
Susic D, etal., J Hypertens. 2011 Apr;29(4):716-23.
106.
Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution.
Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
107.
Angiotensin II type 1 receptor blockade prevents up-regulation of angiotensin II type 1A receptors in rat injured artery.
Tazawa S, etal., J Pharmacol Exp Ther. 1999 Feb;288(2):898-904.
108.
G Protein-Coupled Receptors Directly Bind Filamin A with High Affinity and Promote Filamin Phosphorylation.
Tirupula KC, etal., Biochemistry. 2015 Nov 10;54(44):6673-83. doi: 10.1021/acs.biochem.5b00975. Epub 2015 Nov 2.
109.
Renoprotective mechanisms of angiotensin II antagonism in experimental chronic renal failure.
Uhlenius N, etal., Kidney Blood Press Res. 2002;25(2):71-9.
110.
Addition of angiotensin II type 1 receptor blocker to CCR2 antagonist markedly attenuates crescentic glomerulonephritis.
Urushihara M, etal., Hypertension. 2011 Mar;57(3):586-93. Epub 2011 Jan 31.
111.
Inhibition of corneal neovascularization by blocking the angiotensin II type 1 receptor.
Usui T, etal., Invest Ophthalmol Vis Sci. 2008 Oct;49(10):4370-6. doi: 10.1167/iovs.07-0964.
112.
Selective silencing of angiotensin receptor subtype 1a (AT1aR) by RNA interference.
Vazquez J, etal., Hypertension. 2005 Jan;45(1):115-9. Epub 2004 Nov 29.
113.
Positive feedback regulation of angiotensin II-AT1B receptor gene expression in rat adrenal glands.
Wagner C and Kurtz A, Pflugers Arch. 1998 Aug;436(3):323-8.
114.
Regulation of type 1 angiotensin II receptor and its subtype gene expression in kidney by sodium loading and angiotensin II infusion.
Wang DH, etal., J Hypertens. 1996 Dec;14(12):1409-15.
115.
[Role of angiotensin II type 1 receptor in activation of nuclear factor-kappaB and activator protein-1 in lung of mice with acute lung injury].
Wang F, etal., Zhonghua Shao Shang Za Zhi. 2010 Apr;26(2):113-6.
116.
Effect of valsartan on the expression of angiotensin II receptors in the lung of chronic antigen exposure rats.
Wang T, etal., Chin Med J (Engl). 2008 Nov 20;121(22):2312-9.
117.
Angiotensin II type 2 receptor antagonist reduces bleomycin-induced pulmonary fibrosis in mice.
Waseda Y, etal., Respir Res. 2008 May 23;9:43.
118.
Estrogen regulates adrenal angiotensin AT1 receptors by modulating AT1 receptor translation.
Wu Z, etal., Endocrinology. 2003 Jul;144(7):3251-61.
119.
[The relationship between angiotensin II type 1 receptor gene and coronary heart disease, hypertension and diabetes mellitus in Chinese]
Xiang K, etal., Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 1998 Feb 10;15(1):9-12.
120.
Exercise training combined with angiotensin II receptor blockade limits post-infarct ventricular remodelling in rats.
Xu X, etal., Cardiovasc Res. 2008 Jun 1;78(3):523-32. doi: 10.1093/cvr/cvn028. Epub 2008 Feb 5.
121.
Conformational switch of angiotensin II type 1 receptor underlying mechanical stress-induced activation.
Yasuda N, etal., EMBO Rep. 2008 Feb;9(2):179-86. doi: 10.1038/sj.embor.7401157. Epub 2008 Jan 18.
122.
Epistatic interaction between variations in the angiotensin I converting enzyme and angiotensin II type 1 receptor genes in relation to extent of coronary atherosclerosis.
Ye S, etal., Heart. 2003 Oct;89(10):1195-9.
123.
Activation of D3 dopamine receptor decreases angiotensin II type 1 receptor expression in rat renal proximal tubule cells.
Zeng C, etal., Circ Res. 2006 Sep 1;99(5):494-500. Epub 2006 Aug 10.
124.
Effects of RNA interference targeting angiotensin 1a receptor on the blood pressure and cardiac hypertrophy of rats with 2K1C hypertension
Zhang JQ, etal., Zhonghua Yi Xue Za Zhi. 2006 Apr 25;86(16):1138-43.
125.
Activation of the AT1 angiotensin receptor is dependent on adjacent apolar residues in the carboxyl terminus of the third cytoplasmic loop.
Zhang M, etal., J Biol Chem. 2000 May 26;275(21):15782-8. doi: 10.1074/jbc.M000198200.
126.
Association of angiotensin II type 1 receptor gene polymorphism with carotid atherosclerosis.
Zhu S and Meng QH, Clin Chem Lab Med. 2006;44(3):282-4.
127.
Regulation of angiotensin-(1-7) and angiotensin II type 1 receptor by telmisartan and losartan in adriamycin-induced rat heart failure.
Zong WN, etal., Acta Pharmacol Sin. 2011 Nov;32(11):1345-50. doi: 10.1038/aps.2011.96. Epub 2011 Oct 3.
Agtr1a Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 17 34,383,397 - 34,435,523 (-) NCBI GRCr8 mRatBN7.2 17 34,173,446 - 34,226,892 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 17 34,174,429 - 34,226,946 (-) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 17 34,003,015 - 34,054,637 (-) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 17 35,606,893 - 35,658,508 (-) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 17 33,998,820 - 34,050,440 (-) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 17 35,907,102 - 35,958,136 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 17 35,907,108 - 35,958,077 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 17 37,217,810 - 37,270,540 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 17 40,629,318 - 40,684,982 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 17 40,632,160 - 40,687,823 (-) NCBI Celera 17 33,705,975 - 33,757,157 (-) NCBI Celera Cytogenetic Map 17 p12 NCBI
AGTR1 Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 3 148,697,903 - 148,743,003 (+) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl 3 148,697,784 - 148,743,008 (+) Ensembl GRCh38 hg38 GRCh38 GRCh37 3 148,415,690 - 148,460,790 (+) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 3 149,898,348 - 149,943,480 (+) NCBI NCBI36 Build 36 hg18 NCBI36 Build 34 3 149,940,284 - 149,943,486 NCBI Celera 3 146,826,000 - 146,871,131 (+) NCBI Celera Cytogenetic Map 3 q24 NCBI HuRef 3 145,788,031 - 145,833,163 (+) NCBI HuRef CHM1_1 3 148,378,782 - 148,423,918 (+) NCBI CHM1_1 T2T-CHM13v2.0 3 151,448,936 - 151,494,033 (+) NCBI T2T-CHM13v2.0
Agtr1a Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 13 30,520,339 - 30,566,850 (+) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 13 30,520,424 - 30,566,850 (+) Ensembl GRCm39 Ensembl GRCm38 13 30,336,356 - 30,382,867 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 13 30,336,441 - 30,382,867 (+) Ensembl GRCm38 mm10 GRCm38 MGSCv37 13 30,428,225 - 30,474,736 (+) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 13 30,343,922 - 30,390,332 (+) NCBI MGSCv36 mm8 Celera 13 30,550,710 - 30,597,281 (+) NCBI Celera Cytogenetic Map 13 A3.2 NCBI cM Map 13 13.19 NCBI
Agtr1 Chinchilla Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChiLan1.0 Ensembl NW_004955474 8,733,942 - 8,781,255 (-) Ensembl ChiLan1.0 ChiLan1.0 NW_004955474 8,733,942 - 8,781,305 (-) NCBI ChiLan1.0 ChiLan1.0
AGTR1 Bonobo Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl NHGRI_mPanPan1-v2 2 146,594,053 - 146,639,172 (+) NCBI NHGRI_mPanPan1-v2 NHGRI_mPanPan1 3 146,599,078 - 146,643,902 (+) NCBI NHGRI_mPanPan1 Mhudiblu_PPA_v0 3 145,722,475 - 145,767,550 (+) NCBI Mhudiblu_PPA_v0 Mhudiblu_PPA_v0 panPan3 PanPan1.1 3 153,301,331 - 153,346,268 (+) NCBI panpan1.1 PanPan1.1 panPan2 PanPan1.1 Ensembl 3 153,341,947 - 153,345,380 (+) Ensembl panpan1.1 panPan2
AGTR1 Dog Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl CanFam3.1 23 43,569,658 - 43,617,113 (+) NCBI CanFam3.1 CanFam3.1 canFam3 CanFam3.1 CanFam3.1 Ensembl 23 43,614,035 - 43,616,238 (+) Ensembl CanFam3.1 canFam3 CanFam3.1 Dog10K_Boxer_Tasha 23 43,434,074 - 43,481,582 (+) NCBI Dog10K_Boxer_Tasha ROS_Cfam_1.0 23 44,190,631 - 44,238,133 (+) NCBI ROS_Cfam_1.0 UMICH_Zoey_3.1 23 43,779,664 - 43,827,179 (+) NCBI UMICH_Zoey_3.1 UNSW_CanFamBas_1.0 23 43,832,799 - 43,880,312 (+) NCBI UNSW_CanFamBas_1.0 UU_Cfam_GSD_1.0 23 44,086,806 - 44,134,323 (+) NCBI UU_Cfam_GSD_1.0
Agtr1 Squirrel Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl HiC_Itri_2 NW_024405602 82,859,961 - 82,902,941 (+) NCBI HiC_Itri_2 SpeTri2.0 Ensembl NW_004936519 6,831,096 - 6,873,985 (-) Ensembl SpeTri2.0 SpeTri2.0 Ensembl SpeTri2.0 NW_004936519 6,831,096 - 6,873,977 (-) NCBI SpeTri2.0 SpeTri2.0 SpeTri2.0
AGTR1 Pig Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Sscrofa11.1 Ensembl 13 88,934,868 - 88,983,105 (+) Ensembl Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa11.1 13 88,934,873 - 88,980,317 (+) NCBI Sscrofa11.1 Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa10.2 13 96,933,114 - 96,978,419 (+) NCBI Sscrofa10.2 Sscrofa10.2 susScr3
AGTR1
Agtr1
.
Predicted Target Of
Count of predictions: 118 Count of miRNA genes: 89 Interacting mature miRNAs: 106 Transcripts: ENSRNOT00000038532 Prediction methods: Miranda, Rnahybrid, Targetscan Result types: miRGate_prediction
1354581 Bp247 Blood pressure QTL 247 4.5 arterial blood pressure trait (VT:2000000) pulse pressure (CMO:0000292) 17 1 69599340 Rat 2300002 Iddm36 Insulin dependent diabetes mellitus QTL 36 1.98 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 17 9991286 40540197 Rat 1354640 Scl32 Serum cholesterol level QTL 32 5.4 blood HDL cholesterol amount (VT:0000184) blood high density lipoprotein cholesterol level (CMO:0000052) 17 15781592 60781592 Rat 152023626 Bp403 Blood pressure QTL 403 3.86 arterial blood pressure trait (VT:2000000) 17 23930421 79524188 Rat 1300123 Bp194 Blood pressure QTL 194 2.82 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 17 2115149 34551001 Rat 9590107 Sffal7 Serum free fatty acids level QTL 7 4.81 0.001 blood free fatty acid amount (VT:0001553) plasma free fatty acids level (CMO:0000546) 17 28409147 73409147 Rat 2302377 Scl61 Serum cholesterol level QTL 61 4.36 blood HDL cholesterol amount (VT:0000184) serum high density lipoprotein cholesterol level (CMO:0000361) 17 27389946 53481766 Rat 70157 Niddm32 Non-insulin dependent diabetes mellitus QTL 32 4.34 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) 17 22454924 50909196 Rat 724549 Niddm56 Non-insulin dependent diabetes mellitus QTL 56 0.03 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) 17 31990784 76990784 Rat 1354651 Lmblg2 Limb length QTL 2 6 tibia length (VT:0004357) tibia length (CMO:0000450) 17 4299130 69599340 Rat 1354628 Stl13 Serum triglyceride level QTL 13 3.8 blood triglyceride amount (VT:0002644) blood triglyceride level (CMO:0000118) 17 21293039 60781592 Rat 1581512 Cm55 Cardiac mass QTL 55 2.8 0.05 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) 17 27027949 56836890 Rat 10054088 Scort28 Serum corticosterone level QTL 28 2.04 0.0102 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 17 4528038 49528038 Rat 1354630 Cm34 Cardiac mass QTL 34 8.7 heart left ventricle mass (VT:0007031) heart left ventricle wet weight (CMO:0000071) 17 4299130 69599340 Rat 61394 Bp8 Blood pressure QTL 8 2.2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 17 23080567 59555013 Rat 1559055 Bp278 Blood pressure QTL 278 0.04 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 17 23653184 68653184 Rat 10450503 Bp386 Blood pressure QTL 386 0.28 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 17 31368391 62109574 Rat 152025238 Slep14 Serum leptin concentration QTL 14 4.62 blood leptin amount (VT:0005667) 17 24184890 79524188 Rat 1354638 Insul1 Insulin level QTL 1 4.8 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) 17 4299130 69599340 Rat 2313854 Bp343 Blood pressure QTL 343 3.9 life span trait (VT:0005372) age at time of death (CMO:0001193) 17 31990784 50909196 Rat 1354613 Kidm14 Kidney mass QTL 14 6.2 kidney mass (VT:0002707) left kidney wet weight (CMO:0000083) 17 4299130 35837242 Rat 1331765 Hrtrt15 Heart rate QTL 15 4.094 heart pumping trait (VT:2000009) heart rate (CMO:0000002) 17 15330613 55836425 Rat 8552928 Pigfal9 Plasma insulin-like growth factor 1 level QTL 9 9 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) 17 28409147 73409147 Rat 2303627 Vencon8 Ventilatory control QTL 8 0.001 respiration trait (VT:0001943) tidal volume (CMO:0000222) 17 4528038 49528038 Rat 12903980 Cm120 Cardiac mass QTL 120 0.002 heart right ventricle mass (VT:0007033) heart right ventricle weight to body weight ratio (CMO:0000914) 17 23653184 68653184 Rat 12903981 Am17 Aortic mass QTL 17 0.001 aorta mass (VT:0002845) aorta weight to aorta length to body weight ratio (CMO:0002722) 17 23653184 68653184 Rat 4889891 Eae32 Experimental allergic encephalomyelitis QTL 32 4.8 0.0002 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis severity score (CMO:0001419) 17 27027949 36146731 Rat 4889955 Bss93 Bone structure and strength QTL 93 4.4 tibia size trait (VT:0100001) tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727) 17 27027949 60463643 Rat 2303561 Bw91 Body weight QTL 91 2 body mass (VT:0001259) body weight (CMO:0000012) 17 8868462 53868462 Rat 12903982 Kidm70 Kidney mass QTL 70 0.001 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) 17 23653184 70974005 Rat 631207 Niddm41 Non-insulin dependent diabetes mellitus QTL 41 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) 17 1 37830672 Rat 12903978 Cm118 Cardiac mass QTL 118 0.001 heart mass (VT:0007028) heart wet weight to body weight ratio (CMO:0002408) 17 23653184 68653184 Rat 2324621 Coatc5 Coat color QTL 5 coat/hair pigmentation trait (VT:0010463) pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812) 17 31368391 73951021 Rat 12903979 Cm119 Cardiac mass QTL 119 0.001 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) 17 23653184 68653184 Rat 1354619 Bp242 Blood pressure QTL 242 6.3 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 17 24599340 69599340 Rat 1354596 Bw32 Body weight QTL 32 4.5 body mass (VT:0001259) body weight (CMO:0000012) 17 4299130 60781592 Rat 1354662 Rf49 Renal function QTL 49 2.9 blood creatinine amount (VT:0005328) plasma creatinine level (CMO:0000537) 17 1 69599340 Rat 152023740 Bp406 Blood pressure QTL 406 6.06 arterial blood pressure trait (VT:2000000) 17 23930421 79524188 Rat 1354663 Bvd5 Brain ventricular dilatation QTL 5 3.51 0.001 brain ventricle morphology trait (VT:0000822) hydrocephalus severity score (CMO:0001881) 17 31990784 81292925 Rat 7488966 Bp370 Blood pressure QTL 370 0.001 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 17 23653184 57246843 Rat 1354658 Spl8 Serum phospholipid level QTL 8 3.8 blood VLDL phospholipid amount (VT:0010507) blood very low density lipoprotein phospholipid level (CMO:0001571) 17 1 60781592 Rat 152023737 Bp405 Blood pressure QTL 405 5.06 arterial blood pressure trait (VT:2000000) 23930421 79524188 Rat 1354659 Scl68 Serum cholesterol level QTL 68 3.9 blood VLDL cholesterol amount (VT:0005144) blood very low density lipoprotein cholesterol level (CMO:0000648) 17 15781592 60781592 Rat 152023736 Bp404 Blood pressure QTL 404 3.78 arterial blood pressure trait (VT:2000000) 17 23930421 79524188 Rat
D17Arb4
Rat Assembly Chr Position (strand) Source JBrowse GRCr8 17 34,434,111 - 34,434,355 (+) Marker Load Pipeline mRatBN7.2 17 34,225,481 - 34,225,872 (+) MAPPER mRatBN7.2 mRatBN7.2 17 34,225,566 - 34,225,727 (+) MAPPER mRatBN7.2 mRatBN7.2 17 34,225,481 - 34,225,727 (+) MAPPER mRatBN7.2 Rnor_6.0 17 35,956,457 - 35,957,000 NCBI Rnor6.0 Rnor_6.0 17 35,956,457 - 35,956,698 NCBI Rnor6.0 Rnor_5.0 17 37,268,920 - 37,269,463 UniSTS Rnor5.0 Rnor_5.0 17 37,268,920 - 37,269,161 UniSTS Rnor5.0 RGSC_v3.4 17 40,683,664 - 40,683,905 UniSTS RGSC3.4 RGSC_v3.4 17 40,683,663 - 40,683,905 RGD RGSC3.4 RGSC_v3.1 17 40,686,504 - 40,686,746 RGD SHRSP x BN Map 17 26.9699 UniSTS SHRSP x BN Map 17 26.9699 RGD Cytogenetic Map 17 q12 UniSTS
D17Mco9
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 17 34,227,036 - 34,227,298 (+) MAPPER mRatBN7.2 Rnor_6.0 17 35,958,310 - 35,958,571 NCBI Rnor6.0 Rnor_5.0 17 37,270,773 - 37,271,034 UniSTS Rnor5.0 RGSC_v3.4 17 40,685,215 - 40,685,476 UniSTS RGSC3.4 Celera 17 33,757,390 - 33,757,651 UniSTS Cytogenetic Map 17 q12 UniSTS
D17Mco8
Rat Assembly Chr Position (strand) Source JBrowse Rnor_5.0 17 37,271,013 - 37,271,345 UniSTS Rnor5.0 Celera 17 33,757,630 - 33,757,962 UniSTS Cytogenetic Map 17 q12 UniSTS
D17Wox34
Rat Assembly Chr Position (strand) Source JBrowse GRCr8 17 34,435,904 - 34,436,237 (+) Marker Load Pipeline mRatBN7.2 17 34,227,276 - 34,227,609 (+) MAPPER mRatBN7.2 Rnor_6.0 17 35,958,550 - 35,958,882 NCBI Rnor6.0 Rnor_5.0 17 37,271,013 - 37,271,345 UniSTS Rnor5.0 RGSC_v3.4 17 40,685,455 - 40,685,787 UniSTS RGSC3.4 Celera 17 33,757,630 - 33,757,962 UniSTS Cytogenetic Map 17 q12 UniSTS
RH94717
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 17 34,174,927 - 34,175,204 (+) MAPPER mRatBN7.2 Rnor_6.0 17 35,907,271 - 35,907,547 NCBI Rnor6.0 Rnor_5.0 17 37,218,997 - 37,219,273 UniSTS Rnor5.0 RGSC_v3.4 17 40,629,483 - 40,629,759 UniSTS RGSC3.4 Celera 17 33,706,140 - 33,706,416 UniSTS Cytogenetic Map 17 q12 UniSTS
Agtr1a
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 2 102,846,542 - 102,846,612 (+) MAPPER mRatBN7.2 Rnor_6.0 2 105,150,594 - 105,150,663 NCBI Rnor6.0 Rnor_5.0 2 124,880,836 - 124,880,905 UniSTS Rnor5.0 RGSC_v3.4 2 105,504,843 - 105,504,912 UniSTS RGSC3.4 Celera 2 98,216,100 - 98,216,169 UniSTS Cytogenetic Map 2 q24 UniSTS Cytogenetic Map 17 q12 UniSTS
RH130649
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 17 34,174,980 - 34,175,163 (+) MAPPER mRatBN7.2 Rnor_6.0 17 35,907,324 - 35,907,506 NCBI Rnor6.0 Rnor_5.0 17 37,219,050 - 37,219,232 UniSTS Rnor5.0 RGSC_v3.4 17 40,629,536 - 40,629,718 UniSTS RGSC3.4 Celera 17 33,706,193 - 33,706,375 UniSTS Cytogenetic Map 17 q12 UniSTS
UniSTS:256385
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 17 34,175,936 - 34,176,577 (+) MAPPER mRatBN7.2 mRatBN7.2 2 102,846,237 - 102,846,878 (+) MAPPER mRatBN7.2 Rnor_6.0 2 105,150,289 - 105,150,929 NCBI Rnor6.0 Rnor_6.0 17 35,908,280 - 35,908,920 NCBI Rnor6.0 Rnor_5.0 17 37,220,006 - 37,220,646 UniSTS Rnor5.0 Rnor_5.0 2 124,880,531 - 124,881,171 UniSTS Rnor5.0 RGSC_v3.4 17 40,630,492 - 40,631,132 UniSTS RGSC3.4 RGSC_v3.4 2 105,504,538 - 105,505,178 UniSTS RGSC3.4 Celera 2 98,215,795 - 98,216,435 UniSTS Celera 17 33,707,149 - 33,707,789 UniSTS Cytogenetic Map 2 q24 UniSTS Cytogenetic Map 17 q12 UniSTS
Agtr1a
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 17 34,175,886 - 34,176,577 (+) MAPPER mRatBN7.2 Rnor_6.0 17 35,908,230 - 35,908,920 NCBI Rnor6.0 Rnor_5.0 17 37,219,956 - 37,220,646 UniSTS Rnor5.0 RGSC_v3.4 17 40,630,442 - 40,631,132 UniSTS RGSC3.4 Celera 17 33,707,099 - 33,707,789 UniSTS Cytogenetic Map 17 q12 UniSTS
This gene Agtr1a is modified in the following models/strains:
Click on a value in the shaded box below the category label to view a detailed expression data table for that system.
alimentary part of gastrointestinal system
9
11
49
113
91
90
59
25
59
6
218
97
93
45
60
31
Too many to show, limit is 500. Download them if you would like to view them all.
Ensembl Acc Id:
ENSRNOT00000038532 ⟹ ENSRNOP00000034687
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 17 34,174,429 - 34,226,946 (-) Ensembl Rnor_6.0 Ensembl 17 35,907,108 - 35,958,077 (-) Ensembl
Ensembl Acc Id:
ENSRNOT00000102465 ⟹ ENSRNOP00000091615
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 17 34,174,444 - 34,226,675 (-) Ensembl
RefSeq Acc Id:
NM_030985 ⟹ NP_112247
RefSeq Status:
PROVISIONAL
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 17 34,383,401 - 34,435,432 (-) NCBI mRatBN7.2 17 34,174,763 - 34,226,804 (-) NCBI Rnor_6.0 17 35,907,106 - 35,958,077 (-) NCBI Rnor_5.0 17 37,217,810 - 37,270,540 (-) NCBI RGSC_v3.4 17 40,629,318 - 40,684,982 (-) RGD Celera 17 33,705,975 - 33,757,157 (-) RGD
Sequence:
GGGACTGGATGATGCTGTCCCGCTGGAGAGGATTCGTGGCTTGAGTCCTGTTCCACCCGATCACCGATCACCGGGGTGGCCGAGGCCGGTACCAGCGCTGCGGCTCTCTCAGCTCTGCCACATTCCCT
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RefSeq Acc Id:
XM_008771594 ⟹ XP_008769816
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 17 34,383,397 - 34,435,523 (-) NCBI mRatBN7.2 17 34,173,446 - 34,226,892 (-) NCBI Rnor_6.0 17 35,907,102 - 35,958,136 (-) NCBI
Sequence:
GACGCCCCCTAGGCTATAAATATGGAAGTGCCTAGCTGCTGACCTCCAGGCAGTTGGGAGGGAC
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RefSeq Acc Id:
XM_039095335 ⟹ XP_038951263
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 17 34,383,397 - 34,435,523 (-) NCBI mRatBN7.2 17 34,173,446 - 34,226,892 (-) NCBI
RefSeq Acc Id:
NP_112247 ⟸ NM_030985
- UniProtKB:
Q9QVS5 (UniProtKB/Swiss-Prot), P25095 (UniProtKB/Swiss-Prot), A6J7M4 (UniProtKB/TrEMBL)
- Sequence:
MALNSSAEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYL
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RefSeq Acc Id:
XP_008769816 ⟸ XM_008771594
- Peptide Label:
isoform X1
- UniProtKB:
Q9QVS5 (UniProtKB/Swiss-Prot), P25095 (UniProtKB/Swiss-Prot), A6J7M4 (UniProtKB/TrEMBL)
- Sequence:
MALNSSAEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYL
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Ensembl Acc Id:
ENSRNOP00000034687 ⟸ ENSRNOT00000038532
RefSeq Acc Id:
XP_038951263 ⟸ XM_039095335
- Peptide Label:
isoform X1
- UniProtKB:
P25095 (UniProtKB/Swiss-Prot), Q9QVS5 (UniProtKB/Swiss-Prot), A6J7M4 (UniProtKB/TrEMBL)
Ensembl Acc Id:
ENSRNOP00000091615 ⟸ ENSRNOT00000102465
RGD ID: 13700428 Promoter ID: EPDNEW_R10952 Type: multiple initiation site Name: Agtr1a_1 Description: angiotensin II receptor, type 1a SO ACC ID: SO:0000170 Source: EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/ ) Experiment Methods: Single-end sequencing. Position: Rat Assembly Chr Position (strand) Source Rnor_6.0 17 35,958,089 - 35,958,149 EPDNEW
Date
Current Symbol
Current Name
Previous Symbol
Previous Name
Description
Reference
Status
2009-04-03
Agtr1a
angiotensin II receptor, type 1a
Agtr1
angiotensin II receptor, type 1
Nomenclature updated to reflect human and mouse nomenclature
1299863 APPROVED
2008-09-26
Agtr1
angiotensin II receptor, type 1
Agtr1a
angiotensin II receptor, type 1a
Nomenclature updated to reflect human and mouse nomenclature
1299863 APPROVED
2008-02-18
Agtr1a
angiotensin II receptor, type 1a
Agtr1a
angiotensin II receptor, type 1 (AT1A)
Nomenclature updated to reflect human and mouse nomenclature
1299863 APPROVED
2002-06-10
Agtr1a
angiotensin receptor 1a
Name updated
70584 APPROVED
Note Type
Note
Reference
gene_expression
expression is increased in brain microvessels in SHRSP strain compared with WKY rat strain
1553895
gene_expression
expressed in adrenal gland, liver and kidney
1298647
gene_function
receptor for angiotensin II
68888
gene_function
receptor for angiotensin II
69670
gene_process
activation induces cell contraction, proliferation and migration in vascular smooth muscle cells (VSMCs)
68888
gene_process
activation induces cell contraction, proliferation and migration in vascular smooth muscle cells (VSMCs)
69670
gene_process
functions to regulate aldosterone secretion and to control blood pressure and cardiac volume
68888
gene_process
functions to regulate aldosterone secretion and to control blood pressure and cardiac volume
69670
gene_process
may be involved in regulating myocardial efficiency and ischemic contracture
1298607
gene_process
couples to intracellular Ca2+ signaling with vasoconstricting effects on glomerular arterioles
1298648
gene_regulation
repressed by peroxisome proliferator activated receptor gamma (Pparg) through inhibition of Sp1 via a protein-protein interaction
69670
gene_regulation
activation in vascular smooth muscle cells (VSMCs) is mainly through several signaling transduction pathways, including tyrosine kinases and mitogen activated protein kinase
69670
gene_regulation
transcription may be regulated by sodium in adrenal tissue
1298647
gene_regulation
expression may be developmentally regulated
1298647
