Agt (angiotensinogen) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Agt (angiotensinogen) Rattus norvegicus
Analyze
Symbol: Agt
Name: angiotensinogen
RGD ID: 2069
Description: Enables hormone activity. Involved in several processes, including MAPK cascade; positive regulation of amine transport; and regulation of blood pressure. Located in extracellular space. Used to study several diseases, including artery disease (multiple); diabetic retinopathy; gastric ulcer; impotence; and sciatic neuropathy. Biomarker of several diseases, including cerebrovascular disease (multiple); glomerulonephritis (multiple); liver cirrhosis (multiple); lung disease (multiple); and prediabetes syndrome. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; IgA vasculitis; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Orthologous to human AGT (angiotensinogen); PARTICIPATES IN angiotensin (1-7) signaling pathway; angiotensin II signaling pathway via AT2 receptor; angiotensin III signaling pathway via AT1 receptor; INTERACTS WITH (R)-noradrenaline; 1-(5-isoquinolinesulfonyl)-2-methylpiperazine; 11-deoxycorticosterone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ang; AngII; angiotensin II; angiotensinogen (PAT); angiotensinogen (serpin peptidase inhibitor, clade A, member 8); ANRT; MGC105326; PAT; serpin A8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SHR.BN-(D19Rat57-D19Mit7)/Ipcv  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81969,426,540 - 69,447,017 (-)NCBIGRCr8
mRatBN7.21952,529,139 - 52,549,618 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1952,529,185 - 52,540,977 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1959,313,724 - 59,325,510 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01960,165,792 - 60,177,589 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01962,240,179 - 62,251,965 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01957,321,594 - 57,333,460 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1957,321,640 - 57,333,433 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01968,026,182 - 68,038,550 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41954,738,556 - 54,750,349 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11954,743,436 - 54,755,230 (-)NCBI
Celera1951,899,180 - 51,910,819 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 108 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AgtRatalcoholic hepatitis  ISOAGT (Homo sapiens)1601135mRNA:decreased expression:liverRGD 
AgtRatallergic disease susceptibilityISOAGT (Homo sapiens)8142344DNA:polymorphism: :p.M235T (human)RGD 
AgtRatAlzheimer's disease  ISOAGT (Homo sapiens)5129180protein:increased expression:cerebrospinal fluidRGD 
AgtRatAnaphylaxis  ISOAGT (Homo sapiens)8548893 RGD 
AgtRatanti-basement membrane glomerulonephritis  IEP 11039051mRNA more ...RGD 
AgtRatanti-basement membrane glomerulonephritis  IEP 5129185protein:increased expression:kidney and urineRGD 
AgtRatAortic Calcification  IDA 8549476 RGD 
AgtRatAortic Coarctation treatmentISOAGT (Homo sapiens)13432358DNA:polymorphism: :c.704T>C (human)RGD 
AgtRatatherosclerosis treatmentIMP 8549467associated with HypertensionRGD 
AgtRatatrial fibrillation  ISOAGT (Homo sapiens)8548862DNA:polymorphisms and haplotypes:promoter:multipleRGD 
AgtRatbreast cancer susceptibilityISOAGT (Homo sapiens)8548861DNA:polymorphism: :p.M235T (human)RGD 
AgtRatbreast cancer  ISOAGT (Homo sapiens)8548901protein:increased expression:serumRGD 
AgtRatbreast cancer  ISOAGT (Homo sapiens)8548866DNA:polymorphisms more ...RGD 
AgtRatCardiomegaly  IDA 5129174 RGD 
AgtRatCardiomegaly treatmentISOAgt (Mus musculus)155663352 RGD 
AgtRatCardiomegaly  ISOAgt (Mus musculus)8548902 RGD 
AgtRatCardiomegaly  IDA 11039415 RGD 
AgtRatcardiovascular system disease no_associationISOAGT (Homo sapiens)1566492 RGD 
AgtRatcarotid artery disease susceptibilityISOAGT (Homo sapiens)1601136DNA:polymorphism: :p.M235TRGD 
AgtRatcerebrovascular disease susceptibilityISOAGT (Homo sapiens)1601136DNA:polymorphism: :p.M235TRGD 
1 to 20 of 108 rows
1 to 11 of 11 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AgtRatActin-Accumulation Myopathy  ISOAGT (Homo sapiens)8554872ClinVar Annotator: match by term: Actin accumulation myopathyClinVarPMID:28492532
AgtRatcleidocranial dysplasia  ISOAGT (Homo sapiens)8554872ClinVar Annotator: match by term: Large fontanellesClinVarPMID:25741868 and PMID:35005812
AgtRatcongenital disorder of glycosylation type IIq  ISOAGT (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital disorder of glycosylation and type IIqClinVarPMID:24784932 more ...
AgtRatessential hypertension  ISOAGT (Homo sapiens)8554872ClinVar more ...ClinVarPMID:12743009 more ...
AgtRatgastrointestinal stromal tumor  ISOAGT (Homo sapiens)8554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
AgtRatgenetic disease  ISOAGT (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
AgtRathypertension  ISOAGT (Homo sapiens)8554872ClinVar Annotator: match by term: HypertensionClinVarPMID:1394429 more ...
AgtRatmicrocephaly  ISOAGT (Homo sapiens)8554872ClinVar Annotator: match by term: MicrocephalyClinVarPMID:25741868
AgtRatoligohydramnios  ISOAGT (Homo sapiens)8554872ClinVar Annotator: match by term: AnhydramniosClinVarPMID:25741868 and PMID:35005812
AgtRatparathyroid carcinoma  ISOAGT (Homo sapiens)8554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532
AgtRatRenal Tubular Dysgenesis  ISOAGT (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10585456 more ...
1 to 11 of 11 rows
1 to 20 of 75 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AgtRatabdominal aortic aneurysm  ISOAGT (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16514081 more ...
AgtRatAlbuminuria  ISOAGT (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12414515 more ...
AgtRatalcoholic cardiomyopathy  ISOAGT (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22497828
AgtRatAlkalosis  ISOAGT (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:7182184
AgtRatanemia  ISOAGT (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:3524928
AgtRatAnimal Disease Models  ISOAGT (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:34796763
AgtRatanuria  ISOAGT (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:8527259
AgtRataortic aneurysm  ISOAGT (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21925196
AgtRatatherosclerosis  ISOAGT (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21925196 and PMID:22539767
AgtRatBradycardia  ISOAGT (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:9519251
AgtRatCardiac Arrhythmias  ISOAGT (Homo sapiens)11554173CTD more ...CTDPMID:1654493 and PMID:2535056
AgtRatCardiomegaly  ISOAGT (Homo sapiens)11554173CTD more ...CTDPMID:11403367 more ...
AgtRatcardiomyopathy  ISOAGT (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12145768
AgtRatCardiotoxicity  ISOAGT (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:33676887
AgtRatCardiovascular Abnormalities  ISOAGT (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25807386
AgtRatcardiovascular system disease  ISOAGT (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16544732
AgtRatcarotid artery disease  ISOAGT (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12911327
AgtRatCatalepsy  ISOAGT (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:1034924
AgtRatChemical and Drug Induced Liver Injury  ISOAGT (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29499335
AgtRatcholestasis  ISOAGT (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27989131
1 to 20 of 75 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AgtRatRenal Tubular Dysgenesis  ISOAGT (Homo sapiens)7240710 OMIM 

1 to 20 of 798 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AgtRat(+)-catechin multiple interactionsISOAGT (Homo sapiens)6480464[Quercetin co-treated with Catechin] inhibits the reaction [AGT protein affects the localization of NCF1 protein]CTDPMID:22295890
AgtRat(+)-taxifolin decreases expressionISOAgt (Mus musculus)6480464taxifolin results in decreased expression of AGT protein modified formCTDPMID:24269735
AgtRat(1->4)-beta-D-glucan multiple interactionsISOAgt (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of AGT mRNACTDPMID:36331819
AgtRat(R)-lipoic acid multiple interactionsISOAgt (Mus musculus)6480464[Thioctic Acid co-treated with Dietary Fats] results in decreased expression of AGT mRNACTDPMID:27260466
AgtRat(R)-noradrenaline increases abundanceEXP 6480464AGT protein results in increased abundance of NorepinephrineCTDPMID:15741261
AgtRat(R)-noradrenaline affects abundanceEXP 6480464Norepinephrine affects the abundance of AGT proteinCTDPMID:614752
AgtRat(R)-noradrenaline multiple interactionsEXP 6480464carvedilol inhibits the reaction [AGT protein results in increased abundance of Norepinephrine] and Losartan inhibits the reaction [AGT protein results in increased abundance of Norepinephrine]CTDPMID:15741261
AgtRat(R,R,R)-alpha-tocopherol multiple interactionsISOAgt (Mus musculus)6480464alpha-Tocopherol inhibits the reaction [AGT protein results in increased expression of PSMC6 protein] and alpha-Tocopherol inhibits the reaction [AGT protein results in increased phosphorylation of NFKBIA protein]CTDPMID:17532611
AgtRat(S)-amphetamine affects expressionISOAgt (Mus musculus)6480464Dextroamphetamine affects the expression of AGT mRNACTDPMID:12558987
AgtRat1,2-dichloroethane increases expressionISOAgt (Mus musculus)6480464ethylene dichloride results in increased expression of AGT mRNACTDPMID:28960355
AgtRat1-(5-isoquinolinesulfonyl)-2-methylpiperazine multiple interactionsEXP 64804641-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [AGT protein results in increased expression of ADRA1A mRNA] and 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [AGT protein results in increased expression of ADRA1D mRNA]CTDPMID:7900855
AgtRat11-deoxycorticosterone increases activityEXP 6480464Desoxycorticosterone results in increased activity of AGT proteinCTDPMID:9087624
AgtRat11-Hydroxyandrostenedione increases secretionISOAGT (Homo sapiens)6480464AGT protein results in increased secretion of 11-hydroxyandrostenedioneCTDPMID:28235592
AgtRat14,15-EET decreases expressionEXP 648046414 more ...CTDPMID:27428043
AgtRat14,15-EET multiple interactionsEXP 6480464[14 more ...CTDPMID:27428043
AgtRat14,15-EET multiple interactionsISOAgt (Mus musculus)648046414 more ...CTDPMID:27428043
AgtRat14,15-EET increases cleavageEXP 648046414 more ...CTDPMID:27428043
AgtRat15-deoxy-Delta(12,14)-prostaglandin J2 multiple interactionsEXP 648046415-deoxy-delta(12 more ...CTDPMID:18278065
AgtRat17alpha-ethynylestradiol multiple interactionsISOAGT (Homo sapiens)6480464[Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of AGT protein more ...CTDPMID:11095476 and PMID:17519148
AgtRat17alpha-ethynylestradiol increases expressionISOAGT (Homo sapiens)6480464Ethinyl Estradiol results in increased expression of AGT proteinCTDPMID:11095476 and PMID:17374706

1 to 20 of 798 rows

Biological Process
1 to 20 of 163 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AgtRatadenylate cyclase-activating G protein-coupled receptor signaling pathway involved_inISOAgt (Mus musculus)1624291 PMID:27217404 and PMID:28559246RGDPMID:27217404 and PMID:28559246
AgtRataldosterone secretion involved_inISOAgt (Mus musculus)1624291 PMID:22550170RGDPMID:22550170
AgtRataldosterone secretion acts_upstream_of_or_withinISOAgt (Mus musculus)1624291MGI:2136636 PMID:9557921RGDPMID:9557921
AgtRatangiotensin-activated signaling pathway involved_inISOAgt (Mus musculus)1624291 PMID:10425188RGDPMID:10425188
AgtRatangiotensin-activated signaling pathway involved_inISOAGT (Homo sapiens)1624291 PMID:15153556 more ...RGDPMID:15153556 more ...
AgtRatangiotensin-activated signaling pathway involved_inISSUniProtKB:P01019-PRO_00000324581600115GO_REF:0000024BHF-UCLGO_REF:0000024
AgtRatangiotensin-activated signaling pathway involved_inIEAUniProtKB:P01019 and ensembl:ENSP000003556271600115GO_REF:0000107EnsemblGO_REF:0000107
AgtRatangiotensin-activated signaling pathway involved_inISOAGT (Homo sapiens) and UniProtKB:P01019-PRO_00000324581624291 PMID:24296617RGDPMID:24296617
AgtRatangiotensin-mediated drinking behavior  IDA 5129187 RGD 
AgtRatangiotensin-mediated drinking behavior  IMP 8549458 RGD 
AgtRatangiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure acts_upstream_of_or_withinISOAgt (Mus musculus)1624291 PMID:10425188RGDPMID:10425188
AgtRatangiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure involved_inISOAgt (Mus musculus)1624291MGI:1857123 more ...RGDPMID:10425188 and PMID:27217404
AgtRatartery smooth muscle contraction  IDA 5129195 RGD 
AgtRatassociative learning  IDA 1581389 RGD 
AgtRatastrocyte activation acts_upstream_of_or_withinISOAgt (Mus musculus)1624291MGI:2136636 PMID:9734405RGDPMID:9734405
AgtRatblood vessel development acts_upstream_of_or_withinISOAgt (Mus musculus)1624291MGI:2183545 PMID:8675666 and PMID:9466969RGDPMID:8675666 and PMID:9466969
AgtRatblood vessel diameter maintenance involved_inIEAUniProtKB-KW:KW-08381600115GO_REF:0000043UniProtGO_REF:0000043
AgtRatbrain renin-angiotensin system acts_upstream_of_or_withinISOAgt (Mus musculus)1624291 PMID:15499027 and PMID:9878677RGDPMID:15499027 and PMID:9878677
AgtRatbranching involved in ureteric bud morphogenesis NOT|acts_upstream_of_or_withinISOAgt (Mus musculus)1624291MGI:2183545 PMID:8675666RGDPMID:8675666
AgtRatbranching involved in ureteric bud morphogenesis acts_upstream_of_or_withinISOAgt (Mus musculus)1624291 PMID:12657564RGDPMID:12657564
1 to 20 of 163 rows

Cellular Component
1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AgtRatextracellular region is_active_inISOAgt (Mus musculus)1624291 PMID:28559246RGDPMID:28559246
AgtRatextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
AgtRatextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
AgtRatextracellular space  IDA 1581651 RGD 
AgtRatextracellular space located_inIEAInterPro:IPR0002151600115GO_REF:0000002InterProGO_REF:0000002
AgtRatextracellular space located_inISOAgt (Mus musculus)1624291 PMID:10425188 more ...RGDPMID:10425188 more ...
AgtRatextracellular space is_active_inIBAFB:FBgn0002930 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
AgtRatextracellular space is_active_inISOAGT (Homo sapiens)1624291 PMID:4300938RGDPMID:4300938
AgtRatextracellular space located_inISOAGT (Homo sapiens)1624291 PMID:18971559RGDPMID:18971559
AgtRatextracellular space located_inIEAUniProtKB:P01019 and ensembl:ENSP000003556271600115GO_REF:0000107EnsemblGO_REF:0000107
AgtRatextracellular space located_inIDA 8553951PMID:8252633BHF-UCL 
AgtRatmitochondrion NOT|located_inIDA 11079188PMID:23959064ParkinsonsUK-UCL 
1 to 12 of 12 rows

Molecular Function
1 to 20 of 22 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AgtRatgrowth factor activity enablesISOAGT (Homo sapiens)1624291 PMID:10406457RGDPMID:10406457
AgtRatgrowth factor activity enablesIEAUniProtKB:P01019 and ensembl:ENSP000003556271600115GO_REF:0000107EnsemblGO_REF:0000107
AgtRathormone activity enablesIDA 8553767PMID:8348686BHF-UCL 
AgtRathormone activity enablesISOAGT (Homo sapiens)1624291 PMID:1567413RGDPMID:1567413
AgtRathormone activity enablesIEAUniProtKB:P01019 and ensembl:ENSP000003556271600115GO_REF:0000107EnsemblGO_REF:0000107
AgtRatprotein binding enablesISOAGT (Homo sapiens)1624291UniProtKB:C9J082 more ...RGDPMID:16237761 more ...
AgtRatprotein binding enablesISOAGT (Homo sapiens) and UniProtKB:P01019-PRO_00000324591624291UniProtKB:P50052 and PMID:23597562RGDPMID:23597562
AgtRatprotein binding enablesISOAGT (Homo sapiens) and UniProtKB:P01019-PRO_00000324571624291UniProtKB:Q9BYF1 and PMID:10969042RGDPMID:10969042
AgtRatprotein binding enablesISOAGT (Homo sapiens) and UniProtKB:P01019-PRO_00000324581624291UniProtKB:P30556 more ...RGDPMID:23597562 and PMID:33453855
AgtRatprotein binding enablesISOAGT (Homo sapiens) more ...1624291UniProtKB:Q9BYF1 and PMID:11815627RGDPMID:11815627
AgtRatreceptor ligand activity enablesISOAgt (Mus musculus)1624291MGI:87966 more ...RGDPMID:10425188 more ...
AgtRatreceptor ligand activity enablesISSUniProtKB:P01019-PRO_00000324581600115GO_REF:0000024BHF-UCLGO_REF:0000024
AgtRatreceptor ligand activity enablesISOAGT (Homo sapiens) and UniProtKB:P01019-PRO_00000324581624291 PMID:24296617RGDPMID:24296617
AgtRatserine-type endopeptidase inhibitor activity enablesIEAInterPro:IPR0002151600115GO_REF:0000002InterProGO_REF:0000002
AgtRatserine-type endopeptidase inhibitor activity enablesIBAMGI:891970 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
AgtRatsodium channel regulator activity enablesISOAGT (Homo sapiens) and UniProtKB:P01019-PRO_00004206601624291 PMID:15803439 and PMID:17703433RGDPMID:15803439 and PMID:17703433
AgtRattype 1 angiotensin receptor binding enablesIEAUniProtKB:P01019 and ensembl:ENSP000003556271600115GO_REF:0000107EnsemblGO_REF:0000107
AgtRattype 1 angiotensin receptor binding enablesISOAgt (Mus musculus)1624291 PMID:9878677RGDPMID:9878677
AgtRattype 1 angiotensin receptor binding enablesISOAGT (Homo sapiens)1624291UniProtKB:P30556 and PMID:1378723RGDPMID:1378723
AgtRattype 2 angiotensin receptor binding enablesIEAUniProtKB:P01019 and ensembl:ENSP000003556271600115GO_REF:0000107EnsemblGO_REF:0000107
1 to 20 of 22 rows

Imported Annotations - SMPDB

1 to 20 of 20 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AgtRatbenazepril pharmacodynamics pathway  ISOAGT (Homo sapiens)10402751 SMPDBSMP:00145
AgtRatcandesartan pharmacodynamics pathway  ISOAGT (Homo sapiens)10402751 SMPDBSMP:00158
AgtRatcaptopril pharmacodynamics pathway  ISOAGT (Homo sapiens)10402751 SMPDBSMP:00146
AgtRatcilazapril pharmacodynamics pathway  ISOAGT (Homo sapiens)10402751 SMPDBSMP:00147
AgtRatenalapril pharmacodynamics pathway  ISOAGT (Homo sapiens)10402751 SMPDBSMP:00148
AgtRateprosartan pharmacodynamics pathway  ISOAGT (Homo sapiens)10402751 SMPDBSMP:00159
AgtRatforasartsn pharmacodynamics pathway  ISOAGT (Homo sapiens)10402751 SMPDBSMP:00160
AgtRatfosinopril pharmacodynamics pathway  ISOAGT (Homo sapiens)10402751 SMPDBSMP:00149
AgtRatirbesartan pharmacodynamics pathway  ISOAGT (Homo sapiens)10402751 SMPDBSMP:00161
AgtRatlisinopril pharmacodynamics pathway  ISOAGT (Homo sapiens)10402751 SMPDBSMP:00150
AgtRatlosartan pharmacodynamics pathway   ISOAGT (Homo sapiens)10402751 SMPDBSMP:00162
AgtRatmoexipril pharmacodynamics pathway  ISOAGT (Homo sapiens)10402751 SMPDBSMP:00151
AgtRatolmesartan pharmacodynamics pathway  ISOAGT (Homo sapiens)10402751 SMPDBSMP:00163
AgtRatperindopril pharmacodynamics pathway  ISOAGT (Homo sapiens)10402751 SMPDBSMP:00152
AgtRatquinapril pharmacodynamics pathway  ISOAGT (Homo sapiens)10402751 SMPDBSMP:00153
AgtRatramipril pharmacodynamics pathway  ISOAGT (Homo sapiens)10402751 SMPDBSMP:00154
AgtRatspirapril pharmacodynamics pathway  ISOAGT (Homo sapiens)10402751 SMPDBSMP:00156
AgtRattelmisartan pharmacodynamics pathway  ISOAGT (Homo sapiens)10402751 SMPDBSMP:00164
AgtRattrandolapril pharmacodynamics pathway  ISOAGT (Homo sapiens)10402751 SMPDBSMP:00157
AgtRatvalsartan pharmacodynamics pathway  ISOAGT (Homo sapiens)10402751 SMPDBSMP:00165
1 to 20 of 20 rows

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AgtRatrenin-angiotensin cascade pathway   IEA 6907045 KEGGrno:04614

1 to 20 of 168 rows
#
Reference Title
Reference Citation
1. Attenuation of angiotensin II-induced hypertension and cardiac hypertrophy in transgenic mice overexpressing a type 1 receptor mutant. Ahmad S, etal., Am J Hypertens. 2009 Dec;22(12):1320-5. doi: 10.1038/ajh.2009.181. Epub 2009 Sep 24.
2. Pregnancy protects against antiangiogenic and fibrogenic effects of angiotensin II in rat hearts. Aljabri MB, etal., Acta Physiol (Oxf). 2011 Apr;201(4):445-456. doi: 10.1111/j.1748-1716.2010.02234.x. Epub 2011 Feb 1.
3. Metabolic syndrome biomarkers and early breast cancer in Saudi women: evidence for the presence of a systemic stress response and/or a pre-existing metabolic syndrome-related neoplasia risk? Alokail MS, etal., BMC Cancer. 2013 Feb 4;13:54. doi: 10.1186/1471-2407-13-54.
4. Role of 20-hydroxyeicosatetraenoic acid in the renal and vasoconstrictor actions of angiotensin II. Alonso-Galicia M, etal., Am J Physiol Regul Integr Comp Physiol 2002 Jul;283(1):R60-8.
5. Angiotensinogen promoter and angiotensinogen II receptor type 1 gene polymorphisms and incidence of ischemic stroke and neurologic phenotype in Fabry disease. Altarescu G, etal., Biomarkers. 2013 Nov;18(7):595-600. doi: 10.3109/1354750X.2013.836244. Epub 2013 Sep 10.
6. Regulation of L-type inward calcium channel activity by captopril and angiotensin II via the phosphatidyl inositol 3-kinase pathway in cardiomyocytes from volume-overload hypertrophied rat hearts. Alvin Z, etal., Can J Physiol Pharmacol. 2011 Mar;89(3):206-15.
7. Genetic mapping of a neurological mutation cerebellar calcification in the rat. Ando Y, etal., Mamm Genome 2001 Jan;12(1):80-2.
8. Candesartan cilexetil protects from cardiac myosin induced cardiotoxicity via reduction of endoplasmic reticulum stress and apoptosis in rats: involvement of ACE2-Ang (1-7)-mas axis. Arumugam S, etal., Toxicology. 2012 Jan 27;291(1-3):139-45. doi: 10.1016/j.tox.2011.11.008. Epub 2011 Nov 23.
9. Distinct mechanisms underlie the regulation of body fluid balance by neurokinin B and angiotensin II in the rat brain. Asami R, etal., Brain Res. 2011 Apr 6;1383:179-86. Epub 2011 Jan 28.
10. No evidence for a local renin-angiotensin system in liver mitochondria. Astin R, etal., Sci Rep. 2013;3:2467. doi: 10.1038/srep02467.
11. Lack of association between angiotensinogen polymorphism (M235T) and cerebrovascular disease and carotid atheroma. Barley J, etal., J Hum Hypertens. 1995 Aug;9(8):681-3.
12. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
13. Rat angiotensinogen and des(angiotensin I)angiotensinogen: purification, characterization, and partial sequencing. Bouhnik J, etal., Biochemistry 1981 Nov 24;20(24):7010-5.
14. Involvement of D1 dopamine receptors in the cognitive effects of angiotensin IV and des-Phe6 angiotensin IV. Braszko JJ Peptides. 2004 Jul;25(7):1195-203.
15. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
16. The renin-angiotensin and the kallikrein-kinin systems. Campbell DJ Int J Biochem Cell Biol. 2003 Jun;35(6):784-91.
17. Genetic predisposition to thrombophilia in inflammatory bowel disease. Cappello M, etal., J Clin Gastroenterol. 2011 Mar;45(3):e25-9. doi: 10.1097/MCG.0b013e3181eb6132.
18. Estrogen elicits dorsal root ganglion axon sprouting via a renin-angiotensin system. Chakrabarty A, etal., Endocrinology. 2008 Jul;149(7):3452-60. doi: 10.1210/en.2008-0061. Epub 2008 Apr 3.
19. Promoter polymorphism G-6A, which modulates angiotensinogen gene expression, is associated with non-familial sick sinus syndrome. Chen JY, etal., PLoS One. 2012;7(1):e29951. doi: 10.1371/journal.pone.0029951. Epub 2012 Jan 5.
20. Ang-(1-7) might prevent the development of monocrotaline induced pulmonary arterial hypertension in rats. Chen L, etal., Eur Rev Med Pharmacol Sci. 2011 Jan;15(1):1-7.
1 to 20 of 168 rows
1 to 10 of 33 rows
PMID:1378723   PMID:4344907   PMID:7622467   PMID:7989296   PMID:8675666   PMID:9196031   PMID:9310306   PMID:9507198   PMID:9557921   PMID:9734405   PMID:9788961   PMID:9852267  
PMID:9878677   PMID:10076178   PMID:10318840   PMID:10406457   PMID:10425188   PMID:11384650   PMID:11606482   PMID:12072911   PMID:12221292   PMID:12431451   PMID:12512691   PMID:12574102  
PMID:12623964   PMID:12657564   PMID:12660888   PMID:12660889   PMID:12697701   PMID:12730191   PMID:12782411   PMID:12874086   PMID:14517903   PMID:14523024   PMID:14674692   PMID:14697237  
PMID:15001568   PMID:15061159   PMID:15087286   PMID:15100095   PMID:15153556   PMID:15213258   PMID:15238256   PMID:15245869   PMID:15489334   PMID:15499027   PMID:15539634   PMID:15561758  
PMID:15582710   PMID:15642775   PMID:15652490   PMID:15659559   PMID:15692220   PMID:15710779   PMID:15803439   PMID:15826947   PMID:15869764   PMID:15922295   PMID:15942049   PMID:15944340  
PMID:16020656   PMID:16051229   PMID:16106038   PMID:16115032   PMID:16115033   PMID:16115039   PMID:16116425   PMID:16146787   PMID:16158334   PMID:16176966   PMID:16322063   PMID:16374517  
PMID:16478781   PMID:16502470   PMID:16522658   PMID:16569213   PMID:16574788   PMID:16585392   PMID:16650497   PMID:16728497   PMID:16780972   PMID:16807546   PMID:16837467   PMID:16864744  
PMID:16933034   PMID:16989733   PMID:17029249   PMID:17060503   PMID:17082724   PMID:17259738   PMID:17327451   PMID:17357790   PMID:17360810   PMID:17404180   PMID:17416596   PMID:17466950  
PMID:17483239   PMID:17491111   PMID:17496209   PMID:17507603   PMID:17513012   PMID:17526654   PMID:17553505   PMID:17616751   PMID:17626897   PMID:17646572   PMID:17664391   PMID:17693541  
PMID:17702818   PMID:17703433   PMID:17706954   PMID:17710629   PMID:17785632   PMID:17878754   PMID:17891894   PMID:17903697   PMID:17914985   PMID:17932313   PMID:17942570   PMID:17962624  
1 to 10 of 33 rows



Agt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81969,426,540 - 69,447,017 (-)NCBIGRCr8
mRatBN7.21952,529,139 - 52,549,618 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1952,529,185 - 52,540,977 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1959,313,724 - 59,325,510 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01960,165,792 - 60,177,589 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01962,240,179 - 62,251,965 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01957,321,594 - 57,333,460 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1957,321,640 - 57,333,433 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01968,026,182 - 68,038,550 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41954,738,556 - 54,750,349 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11954,743,436 - 54,755,230 (-)NCBI
Celera1951,899,180 - 51,910,819 (-)NCBICelera
Cytogenetic Map19q12NCBI
AGT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381230,702,523 - 230,745,583 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1230,690,776 - 230,745,576 (-)EnsemblGRCh38hg38GRCh38
GRCh371230,838,269 - 230,881,329 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361228,904,892 - 228,916,564 (-)NCBINCBI36Build 36hg18NCBI36
Build 341227,145,019 - 227,156,602NCBI
Celera1204,104,291 - 204,116,358 (-)NCBICelera
Cytogenetic Map1q42.2NCBI
HuRef1201,323,209 - 201,335,277 (-)NCBIHuRef
CHM1_11232,111,282 - 232,123,349 (-)NCBICHM1_1
T2T-CHM13v2.01230,083,077 - 230,126,137 (-)NCBIT2T-CHM13v2.0
Agt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398125,283,326 - 125,296,445 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8125,283,273 - 125,296,445 (-)EnsemblGRCm39 Ensembl
GRCm388124,556,587 - 124,569,706 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8124,556,534 - 124,569,706 (-)EnsemblGRCm38mm10GRCm38
MGSCv378127,080,487 - 127,093,607 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368127,442,677 - 127,455,773 (-)NCBIMGSCv36mm8
Celera8128,860,995 - 128,873,954 (-)NCBICelera
Cytogenetic Map8E2NCBI
cM Map872.81NCBI
Agt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554927,866,833 - 7,873,357 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554927,863,662 - 7,874,863 (+)NCBIChiLan1.0ChiLan1.0
AGT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2118,492,156 - 18,503,638 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1118,684,644 - 18,696,136 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01206,252,141 - 206,263,830 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11211,279,015 - 211,291,044 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1211,279,015 - 211,291,044 (-)Ensemblpanpan1.1panPan2
AGT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.148,681,192 - 8,694,059 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl48,683,798 - 8,693,880 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha48,672,874 - 8,685,743 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.048,705,485 - 8,718,357 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl48,705,603 - 8,718,382 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.148,709,653 - 8,722,523 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.048,831,567 - 8,844,457 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.049,061,768 - 9,074,658 (+)NCBIUU_Cfam_GSD_1.0
Agt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934443,547,972 - 43,555,916 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648419,716,165 - 19,721,261 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648419,713,299 - 19,721,144 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1459,643,292 - 59,656,833 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11459,643,030 - 59,656,835 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21464,380,799 - 64,385,995 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AGT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12567,964,840 - 67,977,006 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2567,962,401 - 67,973,324 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605569,870,396 - 69,882,850 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Agt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477518,849,118 - 18,855,577 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477518,846,222 - 18,856,093 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Agt
173 total Variants

Predicted Target Of
Summary Value
Count of predictions:205
Count of miRNA genes:157
Interacting mature miRNAs:172
Transcripts:ENSRNOT00000024917
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 10 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194997648153225766Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat

1 to 10 of 10 rows

The following Strains have been annotated to Agt
SHR.BN-(D19Rat57-D19Mit7)/Ipcv    




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 43 99 91 90 59 25 59 6 208 91 79 41 53 31



Ensembl Acc Id: ENSRNOT00000024917   ⟹   ENSRNOP00000024917
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1952,529,185 - 52,540,977 (-)Ensembl
Rnor_6.0 Ensembl1957,321,640 - 57,333,433 (-)Ensembl
RefSeq Acc Id: NM_134432   ⟹   NP_602308
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81969,426,584 - 69,438,377 (-)NCBI
mRatBN7.21952,529,184 - 52,540,977 (-)NCBI
Rnor_6.01957,321,639 - 57,333,433 (-)NCBI
Rnor_5.01968,026,182 - 68,038,550 (-)NCBI
RGSC_v3.41954,738,556 - 54,750,349 (-)RGD
Celera1951,899,180 - 51,910,819 (-)RGD
Sequence:
RefSeq Acc Id: XM_039097466   ⟹   XP_038953394
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81969,426,540 - 69,447,017 (-)NCBI
mRatBN7.21952,529,139 - 52,549,618 (-)NCBI
1 to 10 of 10 rows
Protein RefSeqs NP_602308 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953394 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA98779 (Get FASTA)   NCBI Sequence Viewer  
  AAH78741 (Get FASTA)   NCBI Sequence Viewer  
  AAH87679 (Get FASTA)   NCBI Sequence Viewer  
  EDL96732 (Get FASTA)   NCBI Sequence Viewer  
  EDL96733 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024917
  ENSRNOP00000101947
GenBank Protein P01015 (Get FASTA)   NCBI Sequence Viewer  
1 to 10 of 10 rows
RefSeq Acc Id: NP_602308   ⟸   NM_134432
- Peptide Label: precursor
- UniProtKB: P01015 (UniProtKB/Swiss-Prot),   A6KJ10 (UniProtKB/TrEMBL),   A0A8L2UK05 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024917   ⟸   ENSRNOT00000024917
RefSeq Acc Id: XP_038953394   ⟸   XM_039097466
- Peptide Label: isoform X1
- UniProtKB: A0A8L2UK05 (UniProtKB/TrEMBL)
SERPIN

Name Modeler Protein Id AA Range Protein Structure Video
AF-P01015-F1-model_v2 AlphaFold P01015 1-477 view protein structure  
AGT - Oxidized pdb 2x0b P01015 25-477 view protein structure view video
AGT - Reduced pdb 2x0b P01015 25-477 view protein structure view video
AGT - Renin pdb 2x0b P01015 25-477 view protein structure view video


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13701234
Promoter ID:EPDNEW_R11758
Type:multiple initiation site
Name:Agt_1
Description:angiotensinogen
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01957,333,292 - 57,333,352EPDNEW


1 to 32 of 32 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-5244 BioCyc
Ensembl Genes ENSRNOG00000018445 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000024917 ENTREZGENE
  ENSRNOT00000160760 ENTREZGENE
Gene3D-CATH 2.30.39.10 UniProtKB/Swiss-Prot
  3.30.497.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7128542 IMAGE-MGC_LOAD
  IMAGE:7318795 IMAGE-MGC_LOAD
InterPro Angiotensinogen UniProtKB/Swiss-Prot
  Angiotensinogen_serpin_dom UniProtKB/Swiss-Prot
  Serpin_dom UniProtKB/Swiss-Prot
  Serpin_fam UniProtKB/Swiss-Prot
  Serpin_sf UniProtKB/Swiss-Prot
  Serpin_sf_1 UniProtKB/Swiss-Prot
  Serpin_sf_2 UniProtKB/Swiss-Prot
KEGG Report rno:24179 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105326 IMAGE-MGC_LOAD
  MGC:93198 IMAGE-MGC_LOAD
NCBI Gene 24179 ENTREZGENE
PANTHER PTHR11461 UniProtKB/Swiss-Prot
  PTHR11461:SF13 UniProtKB/Swiss-Prot
Pfam Serpin UniProtKB/Swiss-Prot
PharmGKB AGT RGD
PhenoGen Agt PhenoGen
PRINTS ANGIOTENSNGN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018445 RatGTEx
SMART SERPIN UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56574 UniProtKB/Swiss-Prot
UniProt A0A8L2UK05 ENTREZGENE, UniProtKB/TrEMBL
  A6KJ10 ENTREZGENE, UniProtKB/TrEMBL
  A6KJ11_RAT UniProtKB/TrEMBL
  ANGT_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 32 of 32 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-20 Agt  angiotensinogen  Agt  angiotensinogen (serpin peptidase inhibitor, clade A, member 8)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Agt  angiotensinogen (serpin peptidase inhibitor, clade A, member 8)    angiotensinogen  Name updated 1299863 APPROVED
2002-06-10 Agt  angiotensinogen      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_disease associated with the pathogenesis of essential hypertension and preeclampsia 68691
gene_disease associated with the pathogenesis of essential hypertension and preeclampsia 628425
gene_drugs immunoreactive (IR)-ANG secretion is induced by dexamethasone from renal proximal tubular cells (IRPTCs) in a dose-dependent manner 628563
gene_expression levels in brain and cercbrospinal fluid higher at 4 weeks of agen than at either 7 or 16 weeks, whereas levels in plasma are the reverse, lower at 4 weeks of age than at 7 or 16 weeks 1358967
gene_expression prehypertensive SHR rats (4 weeks of age) show higer levels than in control WKY rats in regions adjacent to the rostral third ventricle; in the evolving phase at 7 weeks of age, levels in 9 brain regions, including the nucleus tractus solitarii, are significantly elevated, whereas at 16 weeks (maintenance phase) only 2 regions show significantly elevated levels in SHR rats 1358967
gene_function helps to increase superoxide in medulalry thick ascending limb (mTAL) which scavenges nitric oxide that increases NaCl absorption in mTAL 1357946
gene_mutations_overexpression the La Jolla colony of SHR rats exhibit a G -> C point mutation at position 1684 of the angiotensinogen gene which appears to affect the secondary structure of the mRNA and strengthen its interaction with a 12 kDa mRNA-stabilizing protein in response to stimulation by angioensin II 1358960
gene_mutations_overexpression deletion of a U-rich region at position 1609-1613 in the3' untranslated region essentially abolishes binding between the angiotensinogen mRNA and a 12 kDa mRNA-stabilizing protein 1358960
gene_other the vasoconstrictive effects of angiotensin II on glomerular hemodynamics are increased after unilateral renal denervation, possibly due to an increase in glomerular angiotensin II receptors 1358965
gene_other microinjection of Angoitensin II into the nucleus tractus solitarii of the brain results in a monophasic decrease in blood pressure at lower doses, and a decrease followed by an increase in blood pressure at higher doses; administration of an angiotensin II receptor antagonist elicits a pressor response and tachycardia implying that angiotensin II acts directly through receptors in the NTS to modulate peripheral cardiovascular responses 1358966
gene_other continuous infusion of angiotensin II into the brains of WKY rats for 20 days resulted in increases in blood pressure, drinking behavior and urination for the duration of the test period. This contradicts results from other groups which reported partial or total habituation during prolonged infusion. 1358968
gene_pathway regulation of expression involves the generation of cellular reactive oxygen species (ROS) and activation of the p38 MAPK signal transduction pathway 628563
gene_pathway elevated circulating level of protein will increase the formation of arachidonate 12-lipoxygenase (Alox12, i.e. 20-HETE) in the kidney and peripheral vasculature 628563
gene_process involved in maintaining blood pressure 68691
gene_process involved in maintaining blood pressure 628425
gene_process potent constrictor of isolated-perfused medullary vasa recta vessels 628563
gene_process high level of circulating Ang II causes resetting of the pressure-natriuresis system to elevated levels of arterial blood pressure through the renal retention of sodium and volume expansion 628563
gene_regulation may cause a rise of renal cortical flow due to reduction in plasma because of incremental increase of daily sodium intake 628563
gene_regulation gene expression is additively increased by high glucose and dexamethasone and this increase is inhibited by insulin 628563
gene_regulation renal medullary nitric oxide (NO) serves as a counter regulatory mechanism to buffer the hypertensive effects of high level angiotensin Ang II 628563
gene_regulation high glucose induces gene expression in immortalized renal proximal tubular cells (IRPTCs) 628563
gene_regulation synthesis and secretion are effected by glucocorticoids, estrogens, thyroid hormones, glucagon and insulin, and are negatively regulated by nephrectomy and both acute and chronic inflammatory conditions 1358960
gene_regulation synthesis and secretion stimulated by angiotensin II through a combination of adenylyl cyclase inhibition and angiotensinogen mRNA sabilization by a 12 kDa polysomal protein 1358960