Agt (angiotensinogen) - Rat Genome Database

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Gene: Agt (angiotensinogen) Rattus norvegicus
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Symbol: Agt
Name: angiotensinogen
RGD ID: 2069
Description: Enables hormone activity. Involved in several processes, including MAPK cascade; regulation of amine transport; and regulation of blood pressure. Located in extracellular space. Used to study several diseases, including artery disease (multiple); diabetic retinopathy; gastric ulcer; impotence; and sciatic neuropathy. Biomarker of several diseases, including cerebrovascular disease (multiple); glomerulonephritis (multiple); liver cirrhosis (multiple); lung disease (multiple); and prediabetes syndrome. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Orthologous to human AGT (angiotensinogen); PARTICIPATES IN angiotensin (1-7) signaling pathway; angiotensin II signaling pathway via AT2 receptor; angiotensin III signaling pathway via AT1 receptor; INTERACTS WITH (R)-noradrenaline; 1-(5-isoquinolinesulfonyl)-2-methylpiperazine; 11-deoxycorticosterone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ang; AngII; angiotensin II; angiotensinogen (PAT); angiotensinogen (serpin peptidase inhibitor, clade A, member 8); ANRT; MGC105326; PAT; serpin A8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   SHR.BN-(D19Rat57-D19Mit7)/Ipcv  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81969,426,540 - 69,447,017 (-)NCBIGRCr8
mRatBN7.21952,529,139 - 52,549,618 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1952,529,185 - 52,540,977 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1959,313,724 - 59,325,510 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01960,165,792 - 60,177,589 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01962,240,179 - 62,251,965 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01957,321,594 - 57,333,460 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1957,321,640 - 57,333,433 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01968,026,182 - 68,038,550 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41954,738,556 - 54,750,349 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11954,743,436 - 54,755,230 (-)NCBI
Celera1951,899,180 - 51,910,819 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Actin-Accumulation Myopathy  (ISO)
Albuminuria  (ISO)
alcoholic cardiomyopathy  (ISO)
alcoholic hepatitis  (ISO)
Alkalosis  (ISO)
allergic disease  (ISO)
Alzheimer's disease  (ISO)
Anaphylaxis  (ISO)
anemia  (ISO)
anti-basement membrane glomerulonephritis  (IEP)
anuria  (ISO)
aortic aneurysm  (ISO)
Aortic Calcification  (IDA)
Aortic Coarctation  (ISO)
atherosclerosis  (IMP,ISO)
atrial fibrillation  (ISO)
bipolar disorder  (ISO)
Bradycardia  (ISO)
breast cancer  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiomegaly  (IDA,ISO)
cardiomyopathy  (ISO)
Cardiotoxicity  (ISO)
Cardiovascular Abnormalities  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
Catalepsy  (ISO)
cerebrovascular disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
Chronic Intermittent Hypoxia  (IEP)
chronic myeloid leukemia  (ISO)
cleidocranial dysplasia  (ISO)
cognitive disorder  (ISO)
congenital disorder of glycosylation type IIq  (ISO)
congestive heart failure  (IEP,ISO)
corneal neovascularization  (ISO)
coronary artery disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (IMP,ISO)
Diaphragmatic Hernia  (ISO)
diffuse scleroderma  (ISO)
dilated cardiomyopathy  (IEP,ISO)
Dissecting Aneurysm  (ISO)
Drug Overdose  (ISO)
end stage renal disease  (ISO)
endomyocardial fibrosis  (ISO)
essential hypertension  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (IDA)
Fabry disease  (ISO)
Fetal Growth Retardation  (IEP,ISO)
Fibrosis  (IDA,ISO)
focal segmental glomerulosclerosis  (IEP,ISO)
gastric ulcer  (IDA)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
glomerulonephritis  (IEP,ISO)
glucose intolerance  (ISO)
heart disease  (ISO)
Hemorrhage  (ISO)
Henoch-Schoenlein purpura  (ISO)
hydronephrosis  (ISO)
Hyperalgesia  (ISO)
Hyperemia  (ISO)
hyperhomocysteinemia  (ISO)
hyperinsulinism  (ISO)
hypertension  (IDA,IEP,IMP,ISO)
Hypertensive Nephropathy  (IEP)
hypertrophic cardiomyopathy  (ISO)
Hypertrophy  (ISO)
hypokalemia  (ISO)
Hypotension  (ISO)
IgA glomerulonephritis  (ISO)
impotence  (IDA)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
intermediate coronary syndrome  (ISO)
Intestinal Reperfusion Injury  (IEP)
kidney disease  (ISO)
kidney failure  (ISO)
Left Ventricular Hypertrophy  (ISO)
liver cirrhosis  (IEP,ISO)
malignant hypertension  (ISO)
meconium aspiration syndrome  (IEP)
Metabolic Syndrome  (IEP)
microcephaly  (ISO)
middle cerebral artery infarction  (IEP)
mitral valve prolapse  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (IDA,ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Necrosis  (ISO)
Neointima  (ISO)
nephrosis  (ISO)
Neurobehavioral Manifestations  (ISO)
obesity  (ISO)
oligohydramnios  (ISO)
otosclerosis  (ISO)
parathyroid carcinoma  (ISO)
Peptic Ulcer Hemorrhage  (ISO)
pneumonia  (ISO)
polycystic kidney disease  (IDA)
pre-eclampsia  (ISO)
prediabetes syndrome  (IEP)
Pregnancy-Induced Hypertension  (IEP)
Prenatal Exposure Delayed Effects  (IEP)
primary biliary cholangitis  (IEP)
proteinuria  (ISO)
pulmonary edema  (ISO)
pulmonary fibrosis  (IMP,ISO)
pulmonary hypertension  (IDA)
Puromycin Aminonucleoside Nephrosis  (IEP)
renal hypertension  (ISO)
Renal Tubular Dysgenesis  (ISO)
Reperfusion Injury  (ISO)
retinal vasculitis  (ISO)
retinopathy of prematurity  (ISO)
sciatic neuropathy  (IDA)
sick sinus syndrome  (ISO)
skin melanoma  (ISO)
Stroke  (ISO)
Sudden Death  (ISO)
systemic scleroderma  (ISO)
temporal lobe epilepsy  (IEP)
thrombosis  (ISO)
transient cerebral ischemia  (IEP)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
vascular disease  (ISO)
Vascular Malformations  (ISO)
Vascular Remodeling  (ISO)
Ventricular Dysfunction, Left  (ISO)
Ventricular Remodeling  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-taxifolin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-amphetamine  (ISO)
1,2-dichloroethane  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (EXP)
11-deoxycorticosterone  (EXP)
11-Hydroxyandrostenedione  (ISO)
14,15-EET  (EXP,ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3',5'-cyclic GMP  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-[3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-Hydroperoxy-2-nonenal  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxy-TEMPO  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-phenylbutyric acid  (EXP)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-oxoprostaglandin F1alpha  (EXP)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
8-Br-cAMP  (ISO)
8-hydroxy-2'-deoxyguanosine  (ISO)
AACOCF3  (EXP)
Ac-Ser-Asp-Lys-Pro-OH  (ISO)
acadesine  (EXP)
acetamide  (EXP)
acetylcholine  (ISO)
acetylsalicylic acid  (ISO)
actinomycin D  (EXP,ISO)
adefovir  (EXP)
Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate]  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP,ISO)
aliskiren  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
allopurinol  (EXP)
alpha-cyano-4-hydroxycinnamic acid  (EXP)
amidotrizoic acid  (EXP)
amiloride  (EXP,ISO)
amiodarone  (EXP,ISO)
amitrole  (EXP)
amlodipine  (ISO)
ammonia  (ISO)
ammonium chloride  (EXP)
angiotensin II  (ISO)
ANTIMYCIN  (EXP)
apocynin  (EXP,ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
aspartame  (ISO)
astressin  (EXP)
atenolol  (ISO)
atorvastatin calcium  (EXP)
azoxystrobin  (EXP)
bafilomycin A1  (EXP)
BAPTA  (ISO)
benazepril  (EXP,ISO)
benidipine  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (ISO)
beta-endorphin  (EXP)
biopterin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol F  (ISO)
boric acid  (ISO)
BQ 123  (EXP,ISO)
brefeldin A  (EXP)
brimonidine tartrate  (EXP)
Brodifacoum  (EXP)
bucladesine  (ISO)
butan-1-ol  (EXP,ISO)
butanal  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
calciol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
Calphostin C  (ISO)
candesartan  (EXP,ISO)
Candesartan cilexetil  (EXP,ISO)
captopril  (EXP,ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (EXP)
carmustine  (ISO)
carvedilol  (EXP,ISO)
CCCP  (EXP)
CGP-42112A  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP,ISO)
chromium atom  (EXP)
chymostatin  (EXP,ISO)
ciglitazone  (EXP)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corticosterone  (ISO)
cortisol  (ISO)
crotonaldehyde  (EXP)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (EXP)
D-glucose  (EXP,ISO)
DDE  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dibenziodolium  (EXP,ISO)
diethyl malate  (ISO)
diminazene diaceturate  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
disodium cromoglycate  (EXP)
diuron  (EXP)
dopamine  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
doxycycline  (EXP)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (EXP,ISO)
efonidipine hydrochloride  (ISO)
elcometrine  (ISO)
emodin  (EXP)
enalapril  (EXP,ISO)
enalaprilat dihydrate  (EXP,ISO)
endosulfan  (EXP)
eplerenone  (ISO)
ergosta-4,6,8(14),22-tetraen-3-one  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP)
famotidine  (EXP)
fenofibrate  (ISO)
flavonoids  (ISO)
flutamide  (EXP)
folic acid  (EXP,ISO)
fosinopril  (EXP)
fructose  (EXP,ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (ISO)
furan  (EXP)
furosemide  (ISO)
genistein  (ISO)
gentamycin  (EXP)
Ginkgoic acid  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glutathione disulfide  (ISO)
glycerol  (EXP)
glycochenodeoxycholic acid  (EXP)
glyphosate  (EXP)
goralatide  (ISO)
Harpagide  (ISO)
heparin  (EXP)
hydralazine  (EXP,ISO)
hydrazines  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
ibuprofen  (EXP)
icatibant  (EXP)
ICI 118551  (ISO)
Ile(5)-angiotensin II  (ISO)
imidacloprid  (EXP)
imidaprilat  (ISO)
imperatorin  (EXP)
indometacin  (EXP,ISO)
iohexol  (EXP)
irbesartan  (EXP,ISO)
irinotecan  (ISO)
isoprenaline  (EXP,ISO)
isorhamnetin  (EXP)
Isorhapontigenin  (EXP)
ketamine  (EXP,ISO)
ketoconazole  (EXP)
L-ascorbic acid  (EXP,ISO)
L-erythro-biopterin  (ISO)
L-ethionine  (EXP)
labetalol  (ISO)
lactacystin  (EXP)
lead(0)  (EXP,ISO)
levonorgestrel  (ISO)
linoleic acid hydroperoxide  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (ISO)
lisinopril dihydrate  (EXP,ISO)
losartan  (EXP,ISO)
LY294002  (EXP)
Magnolol  (EXP)
malonaldehyde  (EXP,ISO)
mangiferin  (EXP)
medroxyprogesterone acetate  (ISO)
melatonin  (EXP,ISO)
mercaptopurine  (EXP)
mercury dichloride  (EXP)
metformin  (ISO)
methamphetamine  (EXP)
methimazole  (EXP)
methotrexate  (EXP,ISO)
methylglyoxal  (EXP)
mevalonic acid  (EXP)
Mibefradil  (ISO)
microcystin RR  (ISO)
midostaurin  (EXP)
miquelianin  (ISO)
mithramycin  (EXP)
MK-2206  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (EXP)
montelukast  (ISO)
mycophenolic acid  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-desethylamiodarone  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methylnicotinate  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
naloxone  (EXP)
naringin  (ISO)
nebivolol  (EXP)
Neferine  (ISO)
nerolidol  (EXP)
nickel atom  (ISO)
nicorandil  (ISO)
nicotinic acid  (EXP,ISO)
nimesulide  (ISO)
nitric oxide  (EXP,ISO)
nitrites  (EXP)
nitrofen  (EXP)
nitrofurantoin  (EXP)
nitroprusside  (ISO)
NS-398  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
olmesartan  (EXP,ISO)
oltipraz  (EXP,ISO)
omeprazole  (EXP)
ouabain  (EXP)
ozone  (EXP)
Pachymic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
PD 168393  (EXP)
PD123319  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perindopril  (EXP,ISO)
peroxynitrous acid  (ISO)
phenylarsine oxide  (EXP)
phenylephrine  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidic acid  (EXP)
phosphoramidon  (EXP)
pifithrin-?  (EXP)
pindolol  (ISO)
pioglitazone  (EXP)
pirinixic acid  (EXP,ISO)
potassium atom  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
pregabalin  (EXP)
probenecid  (EXP)
progesterone  (ISO)
propanal  (ISO)
propranolol  (ISO)
prostaglandin E1  (ISO)
prostaglandin E2  (EXP)
prostaglandin I2  (EXP)
prostaglandins E  (EXP)
purine-6-thiol  (EXP)
purines  (EXP)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (EXP,ISO)
quinacrine  (ISO)
quinapril hydrochloride  (EXP)
raloxifene  (ISO)
reactive oxygen species  (EXP,ISO)
reboxetine  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
rottlerin  (EXP)
rutin  (EXP)
salubrinal  (EXP)
saralasin  (EXP)
SB 203580  (EXP,ISO)
scopolamine  (ISO)
sevoflurane  (ISO)
sildenafil citrate  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (EXP,ISO)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sodium atom  (EXP,ISO)
sodium chloride  (EXP,ISO)
sodium fluoride  (EXP)
Soman  (EXP)
spironolactone  (EXP,ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sucrose  (EXP)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
superoxide  (EXP,ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
taurine  (EXP)
taurolithocholic acid sulfate  (EXP)
tauroursodeoxycholic acid  (EXP)
telmisartan  (EXP,ISO)
temozolomide  (ISO)
testosterone  (EXP)
Testosterone propionate  (EXP)
tetrachloromethane  (EXP)
tetracycline  (ISO)
Theaflavin 3,3'-digallate  (EXP)
thiabendazole  (EXP)
thioacetamide  (EXP)
thiopental  (ISO)
Thiorphan  (ISO)
Tiron  (EXP,ISO)
titanium dioxide  (EXP,ISO)
torasemide  (EXP)
trandolapril  (EXP,ISO)
trans-piceid  (EXP)
tributylstannane  (EXP,ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triticonazole  (EXP)
troglitazone  (ISO)
tyrphostin AG 1478  (EXP)
U-73122  (EXP)
valproic acid  (ISO)
valsartan  (EXP,ISO)
Vinpocetine  (EXP)
vismodegib  (ISO)
wortmannin  (EXP)
xanthone  (EXP)
xestospongin C  (EXP)
zaragozic acid A  (EXP,ISO)
zearalenone  (ISO)
zinc atom  (EXP,ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of phospholipase C activity  (IMP)
aldosterone secretion  (ISO)
angiotensin-activated signaling pathway  (IEA,ISO,ISS)
angiotensin-mediated drinking behavior  (IDA,IMP)
angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure  (ISO)
artery smooth muscle contraction  (IDA)
associative learning  (IDA)
astrocyte activation  (ISO)
blood vessel development  (ISO)
brain renin-angiotensin system  (ISO)
branching involved in ureteric bud morphogenesis  (ISO)
cell growth involved in cardiac muscle cell development  (IDA)
cell population proliferation  (ISO)
cell surface receptor signaling pathway  (IDA)
cell-matrix adhesion  (ISO)
cellular response to angiotensin  (IEP)
cellular response to mechanical stimulus  (IEP)
cytokine production  (IDA)
drinking behavior  (ISO)
ERK1 and ERK2 cascade  (IDA)
establishment of blood-nerve barrier  (ISO)
extracellular matrix organization  (ISO)
female pregnancy  (IEP)
fibroblast proliferation  (IDA)
G protein-coupled receptor signaling pathway  (IMP,ISO)
hormone metabolic process  (ISO)
intracellular sodium ion homeostasis  (IMP)
kidney development  (IEA,ISO)
maintenance of blood vessel diameter homeostasis by renin-angiotensin  (IEA,ISO)
MAPK cascade  (ISO)
negative regulation of angiogenesis  (IDA)
negative regulation of cell growth  (IMP)
negative regulation of cell population proliferation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neurotrophin TRK receptor signaling pathway  (IEA,ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
negative regulation of tissue remodeling  (IDA)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
neuron apoptotic process  (ISO)
obsolete positive regulation of transforming growth factor beta1 activation  (ISS)
operant conditioning  (IDA)
organ growth  (ISO)
ovarian follicle rupture  (ISO)
peristalsis  (ISO)
positive regulation of blood pressure  (IDA)
positive regulation of branching involved in ureteric bud morphogenesis  (IEA,ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of cardiac muscle cell apoptotic process  (IDA)
positive regulation of cardiac muscle hypertrophy  (IDA)
positive regulation of catalytic activity  (IMP)
positive regulation of cell population proliferation  (IDA)
positive regulation of cytokine production  (ISO)
positive regulation of cytosolic calcium ion concentration  (IDA)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of endothelial cell migration  (IEA,ISO)
positive regulation of epidermal growth factor receptor signaling pathway  (IEA,ISO)
positive regulation of epithelial to mesenchymal transition  (ISO,ISS)
positive regulation of extracellular matrix assembly  (IEA,ISO)
positive regulation of extracellular matrix constituent secretion  (IDA)
positive regulation of extrinsic apoptotic signaling pathway  (IEA,ISO)
positive regulation of fatty acid biosynthetic process  (ISO)
positive regulation of fibroblast proliferation  (IDA)
positive regulation of gap junction assembly  (IEA,ISO)
positive regulation of gene expression  (ISO)
positive regulation of insulin receptor signaling pathway  (IDA)
positive regulation of L-arginine import across plasma membrane  (IDA)
positive regulation of L-lysine import across plasma membrane  (IDA)
positive regulation of macrophage derived foam cell differentiation  (IEA,ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of membrane hyperpolarization  (ISO)
positive regulation of miRNA transcription  (IEA,ISO)
positive regulation of multicellular organism growth  (ISO)
positive regulation of neuron projection development  (IMP)
positive regulation of nitric oxide biosynthetic process  (IDA)
positive regulation of organ growth  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of protein metabolic process  (IEA,ISO)
positive regulation of superoxide anion generation  (IDA)
positive regulation of vascular associated smooth muscle cell migration  (IDA)
positive regulation of vascular associated smooth muscle cell proliferation  (IDA)
protein import into nucleus  (IDA)
regulation of apoptotic process  (IBA,IDA,ISO)
regulation of blood pressure  (ISO)
regulation of calcium ion transport  (IDA)
regulation of cardiac conduction  (IEA,ISO)
regulation of extracellular matrix assembly  (ISO)
regulation of gene expression  (ISO)
regulation of heart rate  (IDA)
regulation of inflammatory response  (ISO)
regulation of long-term neuronal synaptic plasticity  (IMP)
regulation of norepinephrine secretion  (IMP)
regulation of renal output by angiotensin  (ISO)
regulation of systemic arterial blood pressure by circulatory renin-angiotensin  (ISO)
regulation of transmission of nerve impulse  (IDA)
renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure  (ISO)
renal system process  (ISO)
renin-angiotensin regulation of aldosterone production  (IDA,ISO)
response to angiotensin  (ISO)
response to cold  (ISO)
response to estradiol  (IEP)
response to mechanical stimulus  (IEP)
response to muscle activity involved in regulation of muscle adaptation  (IMP)
response to salt stress  (ISO)
smooth muscle cell differentiation  (ISO)
smooth muscle cell proliferation  (IDA,ISO)
stress-activated MAPK cascade  (IDA)
uterine smooth muscle contraction  (IDA)
vascular associated smooth muscle cell proliferation  (ISO)
vasoconstriction  (IDA,IEA)
vasodilation  (IDA)
vasopressin secretion  (ISO)

Cellular Component
extracellular space  (IBA,IDA,IEA,ISO)
mitochondrion  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
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102. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
103. Renin-angiotensin system gene polymorphisms: association with susceptibility to Henoch-Schonlein purpura and renal involvement. Ozkaya O, etal., Clin Rheumatol. 2006 Nov;25(6):861-5. Epub 2006 Mar 7.
104. AT2 receptors: beneficial counter-regulatory role in cardiovascular and renal function. Padia SH and Carey RM, Pflugers Arch. 2013 Jan;465(1):99-110. doi: 10.1007/s00424-012-1146-3. Epub 2012 Sep 5.
105. Renal angiotensin type 2 receptors mediate natriuresis via angiotensin III in the angiotensin II type 1 receptor-blocked rat. Padia SH, etal., Hypertension. 2006 Mar;47(3):537-44. Epub 2005 Dec 27.
106. Survival in type 2 diabetic patients in dialysis and the number of risk alleles in polymorphisms of the renin-angiotensin system genes. Padro-Miquel A, etal., Clin Biochem. 2009 Jan;42(1-2):5-11. doi: 10.1016/j.clinbiochem.2008.10.011. Epub 2008 Nov 5.
107. The predominant role of brain angiotensinogen and angiotensin in environmentally induced hypertension. Peng J, etal., Regul Pept 2002 Dec 31;110(1):25-32.
108. Reduction of cold-induced hypertension by antisense oligodeoxynucleotides to angiotensinogen mRNA and AT1-receptor mRNA in brain and blood. Peng JF, etal., Hypertension. 1998 Jun;31(6):1317-23.
109. Reduced circulating levels of angiotensin-(1--7) in systemic sclerosis: a new pathway in the dysregulation of endothelial-dependent vascular tone control. Pignone A, etal., Ann Rheum Dis. 2007 Oct;66(10):1305-10. Epub 2007 Mar 14.
110. Angiotensinogen M235T and T174M gene polymorphisms in combination doubles the risk of mortality in heart failure. Pilbrow AP, etal., Hypertension. 2007 Feb;49(2):322-7. Epub 2006 Dec 4.
111. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
112. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
113. Genetic analysis of angiotensinogen gene polymorphisms (M235T and T174M) in Romanian patients with essential arterial hypertension. Procopciuc LM, etal., Rom J Intern Med. 2005;43(1-2):61-71.
114. Angiotensin III: a central regulator of vasopressin release and blood pressure. Reaux A, etal., Trends Endocrinol Metab. 2001 May-Jun;12(4):157-62.
115. Cardiovascular effects of microinjections of angiotensin II into the nucleus tractus solitarii. Rettig R, etal., Brain Res 1986 Feb 5;364(2):233-40.
116. Studies of the central cardiovascular and dipsogenic effects of angiotensin II in the rat. Rettig R, etal., Clin Exp Hypertens A 1984;6(10-11):2031-5.
117. The continuing saga of the AT2 receptor: a case of the good, the bad, and the innocuous. Reudelhuber TL Hypertension. 2005 Dec;46(6):1261-2. Epub 2005 Nov 14.
118. GOA pipeline RGD automated data pipeline
119. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
120. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
121. Role of angiotensin II in ischemia/reperfusion-induced leukocyte-endothelium interactions in the colon. Riaz AA, etal., FASEB J. 2004 May;18(7):881-3. doi: 10.1096/fj.03-0502fje. Epub 2004 Mar 4.
122. Polymorphisms of the renin-angiotensin system are associated with blood pressure, atherosclerosis and cerebral white matter pathology. Rijn MJ, etal., J Neurol Neurosurg Psychiatry. 2007 Jan 12;.
123. AT-1 receptor and phospholipase C are involved in angiotensin III modulation of hypothalamic noradrenergic transmission. Rodriguez-Campos M, etal., Cell Mol Neurobiol. 2000 Dec;20(6):747-62.
124. Role of IL-6 in angiotensin II-induced retinal vascular inflammation. Rojas M, etal., Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1709-18. doi: 10.1167/iovs.09-3375. Epub 2009 Oct 15.
125. Molecular characterization of angiotensin II--induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype. Sadoshima J and Izumo S, Circ Res. 1993 Sep;73(3):413-23.
126. Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Sadoshima J, etal., Cell. 1993 Dec 3;75(5):977-84.
127. Effects of imatinib mesylate on renin-angiotensin system (RAS) activity during the clinical course of chronic myeloid leukaemia. Sayitoglu M, etal., J Int Med Res. 2009 Jul-Aug;37(4):1018-28.
128. Angiotensinogen M235T polymorphism and the risk of myocardial infarction and stroke among hypertensive patients on ACE-inhibitors or beta-blockers. Schelleman H, etal., Eur J Hum Genet. 2007 Apr;15(4):478-84. Epub 2007 Feb 14.
129. No evidence for association between the renin-angiotensin-aldosterone system and otosclerosis in a large Belgian-Dutch population. Schrauwen I, etal., Otol Neurotol. 2009 Dec;30(8):1079-83. doi: 10.1097/MAO.0b013e3181ab3058.
130. Angiotensin-II type 1 receptor and NOX2 mediate TCF/LEF and CREB dependent WISP1 induction and cardiomyocyte hypertrophy. Shanmugam P, etal., J Mol Cell Cardiol. 2011 Mar 2.
131. [Effects of Chinese herbal medicine Xuefu Zhuyu Decoction on angiotensin II-induced proliferation and extracellular matrix synthesis of rat cardiac fibroblasts.] Shen Y, etal., Zhong Xi Yi Jie He Xue Bao. 2011 Mar;9(3):313-319.
132. Cardamonin inhibits angiotensin II-induced vascular smooth muscle cell proliferation and migration by downregulating p38 MAPK, Akt, and ERK phosphorylation. Shen YJ, etal., J Nat Med. 2014 Jul;68(3):623-9. doi: 10.1007/s11418-014-0825-0. Epub 2014 Mar 5.
133. Involvement of vascular peroxidase 1 in angiotensin II-induced vascular smooth muscle cell proliferation. Shi R, etal., Cardiovasc Res. 2011 Mar 2.
134. Angiotensin II type 1 receptor blockade restores angiotensin-(1-7)-induced coronary vasodilation in hypertrophic rat hearts. Souza AP, etal., Clin Sci (Lond). 2013 Nov;125(9):449-59. doi: 10.1042/CS20120519.
135. Polymorphisms of renin-angiotensin system genes as a risk factor for high-altitude pulmonary oedema. Stobdan T, etal., J Renin Angiotensin Aldosterone Syst. 2011 Mar 10.
136. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
137. Angiotensin-(1-7) inhibits vascular calcification in rats. Sui YB, etal., Peptides. 2013 Apr;42:25-34. doi: 10.1016/j.peptides.2012.12.023. Epub 2013 Jan 3.
138. Posttranscriptional Control of BNP Gene Expression in Angiotensin II-Induced Hypertension. Suo M, etal., Hypertension 2002 Mar 1;39(3):803-8.
139. Salt-induced renal injury in SHRs is mediated by AT1 receptor activation. Susic D, etal., J Hypertens. 2011 Apr;29(4):716-23.
140. Local renal medullary L-NAME infusion enhances the effect of long-term angiotensin II treatment. Szentivanyi M Jr, etal., Hypertension 1999 Jan;33(1 Pt 2):440-5.
141. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
142. Angiotensinogen gene polymorphism (Met235Thr) influences visceral obesity and insulin resistance in obese Japanese women. Takakura Y, etal., Metabolism. 2006 Jun;55(6):819-24.
143. Angiotensin-(1-7) inhibits growth of cardiac myocytes through activation of the mas receptor. Tallant EA, etal., Am J Physiol Heart Circ Physiol. 2005 Oct;289(4):H1560-6. Epub 2005 Jun 10.
144. The role of HIF-1, angiopoietin-2, Dll4 and Notch1 in bleeding gastrointestinal vascular malformations and thalidomide-associated actions: a pilot in vivo study. Tan HH, etal., J Dig Dis. 2011 Oct;12(5):349-56. doi: 10.1111/j.1751-2980.2011.00506.x.
145. Common structural organization of the angiotensinogen and the alpha 1-antitrypsin genes. Tanaka T, etal., J Biol Chem 1984 Jul 10;259(13):8063-5.
146. Polymorphisms within the angiotensinogen gene (GT-repeat) and the risk of stroke in pediatric patients with sickle cell disease: a case-control study. Tang DC, etal., Am J Hematol. 2001 Nov;68(3):164-9.
147. Renin-angiotensin system gene polymorphisms and atrial fibrillation: a regression approach for the detection of gene-gene interactions in a large hospitalized population. Tsai CT, etal., Cardiology. 2008;111(1):1-7. doi: 10.1159/000113419. Epub 2008 Feb 1.
148. Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes. Tsuchida S, etal., J Clin Invest 1998 Feb 15;101(4):755-60.
149. Changes in glomerular hemodynamic response to angiotensin II after subacute renal denervation in rats. Tucker BJ, etal., J Clin Invest 1986 Sep;78(3):680-8.
150. Addition of angiotensin II type 1 receptor blocker to CCR2 antagonist markedly attenuates crescentic glomerulonephritis. Urushihara M, etal., Hypertension. 2011 Mar;57(3):586-93. Epub 2011 Jan 31.
151. Inhibition of corneal neovascularization by blocking the angiotensin II type 1 receptor. Usui T, etal., Invest Ophthalmol Vis Sci. 2008 Oct;49(10):4370-6. doi: 10.1167/iovs.07-0964.
152. Genetic polymorphisms of the renin-angiotensin system and complications of insulin-dependent diabetes mellitus. van Ittersum FJ, etal., Nephrol Dial Transplant. 2000 Jul;15(7):1000-7.
153. Angiotensinogen promoter sequence variants in essential hypertension. Velez DR, etal., Am J Hypertens. 2006 Dec;19(12):1278-85.
154. ACE2 and Ang-(1-7) confer protection against development of diabetic retinopathy. Verma A, etal., Mol Ther. 2012 Jan;20(1):28-36. doi: 10.1038/mt.2011.155. Epub 2011 Jul 26.
155. Rac1 and RhoA differentially regulate angiotensinogen gene expression in stretched cardiac fibroblasts. Verma SK, etal., Cardiovasc Res. 2011 Apr 1;90(1):88-96. Epub 2010 Dec 3.
156. A molecular variant of angiotensinogen associated with preeclampsia. Ward K, etal., Nat Genet 1993 May;4(1):59-61.
157. Characterisation of a thymic renin-angiotensin system in the transgenic m(Ren-2)27 rat. Wilkinson-Berka JL, etal., Mol Cell Endocrinol. 2002 Aug 30;194(1-2):201-9.
158. Angiotensin II controls occludin function and is required for blood brain barrier maintenance: relevance to multiple sclerosis. Wosik K, etal., J Neurosci. 2007 Aug 22;27(34):9032-42.
159. Counteraction between angiotensin II and angiotensin-(1-7) via activating angiotensin type I and Mas receptor on rat renal mesangial cells. Xue H, etal., Regul Pept. 2012 Aug 20;177(1-3):12-20. doi: 10.1016/j.regpep.2012.04.002. Epub 2012 May 1.
160. Lack of association of polymorphisms of the angiotensin converting enzyme and angiotensinogen genes with nonfamilial hypertrophic or dilated cardiomyopathy. Yamada Y, etal., Am J Hypertens. 1997 Aug;10(8):921-8.
161. Mechanisms of Ghrelin anti-heart failure: inhibition of Ang II-induced cardiomyocyte apoptosis by down-regulating AT1R expression. Yang C, etal., PLoS One. 2014 Jan 21;9(1):e85785. doi: 10.1371/journal.pone.0085785. eCollection 2014.
162. Activation of the renin-angiotensin system in anti-glomerular basement membrane antibody-induced glomerulonephritis. Yayama K, etal., Biol Pharm Bull. 1995 Mar;18(3):411-5.
163. Elevation of plasma angiotensinogen in rats with experimentally induced nephrosis. Yayama K, etal., Nephron. 1993;63(1):89-93.
164. Olmesartan attenuates cardiac remodeling through DLL4/Notch1 pathway activation in pressure overload mice. You J, etal., J Cardiovasc Pharmacol. 2013 Feb;61(2):142-51. doi: 10.1097/FJC.0b013e31827a0278.
165. Impairment of Cardiac Function and Remodeling Induced by Myocardial Infarction in Rats are Attenuated by the Nonpeptide Angiotensin-(1-7) Analog AVE 0991. Zeng WT, etal., Cardiovasc Ther. 2010 Dec 19. doi: 10.1111/j.1755-5922.2010.00255.x.
166. Insulin inhibits dexamethasone effect on angiotensinogen gene expression and induction of hypertrophy in rat kidney proximal tubular cells in high glucose. Zhang SL, etal., Endocrinology 2002 Dec;143(12):4627-35.
167. Angiotensin (1-7) protects against stress-induced gastric lesions in rats. Zhu D, etal., Biochem Pharmacol. 2014 Feb 1;87(3):467-76. doi: 10.1016/j.bcp.2013.10.026. Epub 2013 Nov 11.
168. Regulation of angiotensin-(1-7) and angiotensin II type 1 receptor by telmisartan and losartan in adriamycin-induced rat heart failure. Zong WN, etal., Acta Pharmacol Sin. 2011 Nov;32(11):1345-50. doi: 10.1038/aps.2011.96. Epub 2011 Oct 3.
Additional References at PubMed
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Genomics

Comparative Map Data
Agt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81969,426,540 - 69,447,017 (-)NCBIGRCr8
mRatBN7.21952,529,139 - 52,549,618 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1952,529,185 - 52,540,977 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1959,313,724 - 59,325,510 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01960,165,792 - 60,177,589 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01962,240,179 - 62,251,965 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01957,321,594 - 57,333,460 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1957,321,640 - 57,333,433 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01968,026,182 - 68,038,550 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41954,738,556 - 54,750,349 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11954,743,436 - 54,755,230 (-)NCBI
Celera1951,899,180 - 51,910,819 (-)NCBICelera
Cytogenetic Map19q12NCBI
AGT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381230,702,523 - 230,745,583 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1230,690,776 - 230,745,576 (-)EnsemblGRCh38hg38GRCh38
GRCh371230,838,269 - 230,881,329 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361228,904,892 - 228,916,564 (-)NCBINCBI36Build 36hg18NCBI36
Build 341227,145,019 - 227,156,602NCBI
Celera1204,104,291 - 204,116,358 (-)NCBICelera
Cytogenetic Map1q42.2NCBI
HuRef1201,323,209 - 201,335,277 (-)NCBIHuRef
CHM1_11232,111,282 - 232,123,349 (-)NCBICHM1_1
T2T-CHM13v2.01230,083,077 - 230,126,137 (-)NCBIT2T-CHM13v2.0
Agt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398125,283,326 - 125,296,445 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8125,283,273 - 125,296,445 (-)EnsemblGRCm39 Ensembl
GRCm388124,556,587 - 124,569,706 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8124,556,534 - 124,569,706 (-)EnsemblGRCm38mm10GRCm38
MGSCv378127,080,487 - 127,093,607 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368127,442,677 - 127,455,773 (-)NCBIMGSCv36mm8
Celera8128,860,995 - 128,873,954 (-)NCBICelera
Cytogenetic Map8E2NCBI
cM Map872.81NCBI
Agt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554927,866,833 - 7,873,357 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554927,863,662 - 7,874,863 (+)NCBIChiLan1.0ChiLan1.0
AGT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2118,492,156 - 18,503,638 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1118,684,644 - 18,696,136 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01206,252,141 - 206,263,830 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11211,279,015 - 211,291,044 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1211,279,015 - 211,291,044 (-)Ensemblpanpan1.1panPan2
AGT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.148,681,192 - 8,694,059 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl48,683,798 - 8,693,880 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha48,672,874 - 8,685,743 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.048,705,485 - 8,718,357 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl48,705,603 - 8,718,382 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.148,709,653 - 8,722,523 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.048,831,567 - 8,844,457 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.049,061,768 - 9,074,658 (+)NCBIUU_Cfam_GSD_1.0
Agt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934443,547,972 - 43,555,916 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648419,716,165 - 19,721,261 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648419,713,299 - 19,721,144 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1459,643,292 - 59,656,833 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11459,643,030 - 59,656,835 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21464,380,799 - 64,385,995 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AGT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12567,964,840 - 67,977,006 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2567,962,401 - 67,973,324 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605569,870,396 - 69,882,850 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Agt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477518,849,118 - 18,855,577 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477518,846,222 - 18,856,093 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Agt
173 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:205
Count of miRNA genes:157
Interacting mature miRNAs:172
Transcripts:ENSRNOT00000024917
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194997648153225766Rat


Related Rat Strains
The following Strains have been annotated to Agt
SHR.BN-(D19Rat57-D19Mit7)/Ipcv    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 6 6 6
Medium 1 42 31 8 31 38 8 6 7
Low 2 19 9 4 11 4 8 11 18 11 18 4 8
Below cutoff 18 4 12 10

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000024917   ⟹   ENSRNOP00000024917
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1952,529,185 - 52,540,977 (-)Ensembl
Rnor_6.0 Ensembl1957,321,640 - 57,333,433 (-)Ensembl
RefSeq Acc Id: NM_134432   ⟹   NP_602308
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81969,426,584 - 69,438,377 (-)NCBI
mRatBN7.21952,529,184 - 52,540,977 (-)NCBI
Rnor_6.01957,321,639 - 57,333,433 (-)NCBI
Rnor_5.01968,026,182 - 68,038,550 (-)NCBI
RGSC_v3.41954,738,556 - 54,750,349 (-)RGD
Celera1951,899,180 - 51,910,819 (-)RGD
Sequence:
RefSeq Acc Id: XM_039097466   ⟹   XP_038953394
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81969,426,540 - 69,447,017 (-)NCBI
mRatBN7.21952,529,139 - 52,549,618 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_602308   ⟸   NM_134432
- Peptide Label: precursor
- UniProtKB: P01015 (UniProtKB/Swiss-Prot),   A6KJ10 (UniProtKB/TrEMBL),   A0A8L2UK05 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000024917   ⟸   ENSRNOT00000024917
RefSeq Acc Id: XP_038953394   ⟸   XM_039097466
- Peptide Label: isoform X1
- UniProtKB: A0A8L2UK05 (UniProtKB/TrEMBL)
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure Video
AF-P01015-F1-model_v2 AlphaFold P01015 1-477 view protein structure  
AGT - Oxidized pdb 2x0b P01015 25-477 view protein structure view video
AGT - Reduced pdb 2x0b P01015 25-477 view protein structure view video
AGT - Renin pdb 2x0b P01015 25-477 view protein structure view video

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701234
Promoter ID:EPDNEW_R11758
Type:multiple initiation site
Name:Agt_1
Description:angiotensinogen
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01957,333,292 - 57,333,352EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2069 AgrOrtholog
BioCyc Gene G2FUF-5244 BioCyc
Ensembl Genes ENSRNOG00000018445 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024917 ENTREZGENE
  ENSRNOT00000024917.5 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7128542 IMAGE-MGC_LOAD
  IMAGE:7318795 IMAGE-MGC_LOAD
InterPro Angiotensinogen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Angiotensinogen_serpin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24179 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105326 IMAGE-MGC_LOAD
  MGC:93198 IMAGE-MGC_LOAD
NCBI Gene 24179 ENTREZGENE
PANTHER PTHR11461 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11461:SF13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Serpin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB AGT RGD
PhenoGen Agt PhenoGen
PRINTS ANGIOTENSNGN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018445 RatGTEx
SMART SERPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56574 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2UK05 ENTREZGENE, UniProtKB/TrEMBL
  A6KJ10 ENTREZGENE, UniProtKB/TrEMBL
  A6KJ11_RAT UniProtKB/TrEMBL
  ANGT_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-20 Agt  angiotensinogen  Agt  angiotensinogen (serpin peptidase inhibitor, clade A, member 8)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Agt  angiotensinogen (serpin peptidase inhibitor, clade A, member 8)    angiotensinogen  Name updated 1299863 APPROVED
2002-06-10 Agt  angiotensinogen      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease associated with the pathogenesis of essential hypertension and preeclampsia 68691
gene_disease associated with the pathogenesis of essential hypertension and preeclampsia 628425
gene_drugs immunoreactive (IR)-ANG secretion is induced by dexamethasone from renal proximal tubular cells (IRPTCs) in a dose-dependent manner 628563
gene_expression levels in brain and cercbrospinal fluid higher at 4 weeks of agen than at either 7 or 16 weeks, whereas levels in plasma are the reverse, lower at 4 weeks of age than at 7 or 16 weeks 1358967
gene_expression prehypertensive SHR rats (4 weeks of age) show higer levels than in control WKY rats in regions adjacent to the rostral third ventricle; in the evolving phase at 7 weeks of age, levels in 9 brain regions, including the nucleus tractus solitarii, are significantly elevated, whereas at 16 weeks (maintenance phase) only 2 regions show significantly elevated levels in SHR rats 1358967
gene_function helps to increase superoxide in medulalry thick ascending limb (mTAL) which scavenges nitric oxide that increases NaCl absorption in mTAL 1357946
gene_mutations_overexpression the La Jolla colony of SHR rats exhibit a G -> C point mutation at position 1684 of the angiotensinogen gene which appears to affect the secondary structure of the mRNA and strengthen its interaction with a 12 kDa mRNA-stabilizing protein in response to stimulation by angioensin II 1358960
gene_mutations_overexpression deletion of a U-rich region at position 1609-1613 in the3' untranslated region essentially abolishes binding between the angiotensinogen mRNA and a 12 kDa mRNA-stabilizing protein 1358960
gene_other the vasoconstrictive effects of angiotensin II on glomerular hemodynamics are increased after unilateral renal denervation, possibly due to an increase in glomerular angiotensin II receptors 1358965
gene_other microinjection of Angoitensin II into the nucleus tractus solitarii of the brain results in a monophasic decrease in blood pressure at lower doses, and a decrease followed by an increase in blood pressure at higher doses; administration of an angiotensin II receptor antagonist elicits a pressor response and tachycardia implying that angiotensin II acts directly through receptors in the NTS to modulate peripheral cardiovascular responses 1358966
gene_other continuous infusion of angiotensin II into the brains of WKY rats for 20 days resulted in increases in blood pressure, drinking behavior and urination for the duration of the test period. This contradicts results from other groups which reported partial or total habituation during prolonged infusion. 1358968
gene_pathway regulation of expression involves the generation of cellular reactive oxygen species (ROS) and activation of the p38 MAPK signal transduction pathway 628563
gene_pathway elevated circulating level of protein will increase the formation of arachidonate 12-lipoxygenase (Alox12, i.e. 20-HETE) in the kidney and peripheral vasculature 628563
gene_process involved in maintaining blood pressure 68691
gene_process involved in maintaining blood pressure 628425
gene_process potent constrictor of isolated-perfused medullary vasa recta vessels 628563
gene_process high level of circulating Ang II causes resetting of the pressure-natriuresis system to elevated levels of arterial blood pressure through the renal retention of sodium and volume expansion 628563
gene_regulation may cause a rise of renal cortical flow due to reduction in plasma because of incremental increase of daily sodium intake 628563
gene_regulation gene expression is additively increased by high glucose and dexamethasone and this increase is inhibited by insulin 628563
gene_regulation renal medullary nitric oxide (NO) serves as a counter regulatory mechanism to buffer the hypertensive effects of high level angiotensin Ang II 628563
gene_regulation high glucose induces gene expression in immortalized renal proximal tubular cells (IRPTCs) 628563
gene_regulation synthesis and secretion are effected by glucocorticoids, estrogens, thyroid hormones, glucagon and insulin, and are negatively regulated by nephrectomy and both acute and chronic inflammatory conditions 1358960
gene_regulation synthesis and secretion stimulated by angiotensin II through a combination of adenylyl cyclase inhibition and angiotensinogen mRNA sabilization by a 12 kDa polysomal protein 1358960