Adcy8 (adenylate cyclase 8) - Rat Genome Database

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Gene: Adcy8 (adenylate cyclase 8) Rattus norvegicus
Analyze
Symbol: Adcy8
Name: adenylate cyclase 8
RGD ID: 2036
Description: Enables several functions, including calcium- and calmodulin-responsive adenylate cyclase activity; calmodulin binding activity; and protein dimerization activity. Involved in several processes, including G protein-coupled receptor signaling pathway; activation of protein kinase A activity; and cAMP biosynthetic process. Located in several cellular components, including caveola; clathrin-coated pit; and neuronal cell body membrane. Orthologous to human ADCY8 (adenylate cyclase 8); PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ac8; adenylate cyclase 8 (brain); adenylate cyclase type 8; adenylate cyclase type VIII; adenylyl cyclase 8; adenylyl cyclase 8 variant E; adenylyl cyclase 8 variant F; adenylyl cyclase 8 variant G; adenylyl cyclase 8 variant H; ATP pyrophosphate-lyase 8; ca(2+)/calmodulin-activated adenylyl cyclase; type VIII adenylyl cyclase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8798,306,434 - 98,555,687 (-)NCBIGRCr8
mRatBN7.2796,417,310 - 96,665,911 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl796,417,324 - 96,665,911 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx798,176,363 - 98,425,655 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07100,377,999 - 100,627,320 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07100,299,283 - 100,548,591 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07105,353,883 - 105,593,372 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7105,353,913 - 105,592,804 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07105,301,826 - 105,541,014 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47101,957,807 - 102,210,346 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17101,992,036 - 102,244,576 (-)NCBI
Celera792,997,741 - 93,245,305 (-)NCBICelera
Cytogenetic Map7q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
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Qualifier
Evidence
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Original Reference(s)
Adcy8Ratdiabetic angiopathy  ISOADCY8 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25381014
Adcy8RatHyperkinesis  ISOADCY8 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16914643
Adcy8Ratmood disorder  ISOADCY8 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19691954
Adcy8Ratwithdrawal disorder  ISOADCY8 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16914643

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Original Reference(s)
Adcy8Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of ADCY8 mRNACTDPMID:32109520
Adcy8Rat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642 more ...CTDPMID:32109520
Adcy8Rat2-palmitoylglycerol increases expressionISOADCY8 (Homo sapiens)64804642-palmitoylglycerol results in increased expression of ADCY8 mRNACTDPMID:37199045
Adcy8Rat3,4-methylenedioxymethamphetamine decreases expressionEXP 6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of ADCY8 mRNACTDPMID:30071829
Adcy8Rat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOAdcy8 (Mus musculus)6480464[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of ADCY8 mRNACTDPMID:29288687
Adcy8Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of ADCY8 mRNACTDPMID:24780913
Adcy8Ratalpha-Zearalanol multiple interactionsEXP 6480464[Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of ADCY8 mRNACTDPMID:35163327
Adcy8Rataristolochic acid A decreases expressionISOADCY8 (Homo sapiens)6480464aristolochic acid I results in decreased expression of ADCY8 mRNACTDPMID:33212167
Adcy8Ratarsenite(3-) decreases expressionISOAdcy8 (Mus musculus)6480464arsenite results in decreased expression of ADCY8 mRNACTDPMID:33053406
Adcy8Ratarsenite(3-) increases methylationISOADCY8 (Homo sapiens)6480464arsenite results in increased methylation of ADCY8 promoterCTDPMID:23974009
Adcy8Ratbenzo[a]pyrene decreases methylationISOADCY8 (Homo sapiens)6480464Benzo(a)pyrene results in decreased methylation of ADCY8 5' UTRCTDPMID:27901495
Adcy8Ratbenzo[a]pyrene affects methylationISOADCY8 (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of ADCY8 promoterCTDPMID:27901495
Adcy8Ratbeta-naphthoflavone multiple interactionsEXP 6480464[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ADCY8 mRNACTDPMID:18164116
Adcy8Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of ADCY8 mRNACTDPMID:25181051
Adcy8Ratbisphenol A decreases expressionISOAdcy8 (Mus musculus)6480464bisphenol A results in decreased expression of ADCY8 mRNACTDPMID:25594700
Adcy8Ratcarbon nanotube decreases expressionISOAdcy8 (Mus musculus)6480464Nanotubes more ...CTDPMID:25554681
Adcy8RatCGP 52608 multiple interactionsISOADCY8 (Homo sapiens)6480464CGP 52608 promotes the reaction [RORA protein binds to ADCY8 gene]CTDPMID:28238834
Adcy8Ratcocaine affects expressionEXP 6480464Cocaine affects the expression of ADCY8 mRNACTDPMID:20187946
Adcy8Ratcyclosporin A decreases expressionISOADCY8 (Homo sapiens)6480464Cyclosporine results in decreased expression of ADCY8 mRNACTDPMID:20106945
Adcy8Ratdexamethasone multiple interactionsISOAdcy8 (Mus musculus)6480464[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of ADCY8 mRNACTDPMID:29288687

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Biological Process
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Original Reference(s)
Adcy8Ratactivation of protein kinase A activity involved_inIMP 13825194PMID:25381556UniProt 
Adcy8Ratadenylate cyclase-activating G protein-coupled receptor signaling pathway involved_inIMP 8553299PMID:21046358WB 
Adcy8Ratadenylate cyclase-activating G protein-coupled receptor signaling pathway involved_inISOAdcy8 (Mus musculus)1624291MGI:2176596 PMID:25403481 and PMID:9075801RGDPMID:25403481 and PMID:9075801
Adcy8Ratadenylate cyclase-activating G protein-coupled receptor signaling pathway involved_inIBAFB:FBgn0003301 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Adcy8Ratadenylate cyclase-activating G protein-coupled receptor signaling pathway involved_inIEAUniProtKB:P97490 and ensembl:ENSMUSP000000230071600115GO_REF:0000107EnsemblGO_REF:0000107
Adcy8RatcAMP biosynthetic process  IMP 2312769 RGD 
Adcy8RatcAMP biosynthetic process involved_inIBAPANTHER:PTN002899488 and Adcy8 (Rattus norvegicus)1600115GO_REF:0000033GO_CentralGO_REF:0000033
Adcy8RatcAMP biosynthetic process involved_inIEAInterPro:IPR0306721600115GO_REF:0000002InterProGO_REF:0000002
Adcy8RatcAMP biosynthetic process involved_inIEAInterPro:IPR009398 and InterPro:IPR0306721600115GO_REF:0000002InterProGO_REF:0000002
Adcy8RatcAMP biosynthetic process involved_inIEAUniProtKB-KW:KW-01151600115GO_REF:0000043UniProtGO_REF:0000043
Adcy8RatcAMP biosynthetic process involved_inIEAARBA:ARBA000266861600115GO_REF:0000117UniProtGO_REF:0000117
Adcy8RatcAMP biosynthetic process  IMP 7241269 RGD 
Adcy8RatcAMP biosynthetic process  IMP 2312785 RGD 
Adcy8RatcAMP/PKA signal transduction  IDA 69741 RGD 
Adcy8Ratcellular response to calcium ion  IMP 7241269 RGD 
Adcy8Ratcellular response to calcium ion involved_inIDA 7242424PMID:20410303UniProt 
Adcy8Ratcellular response to calcium ion involved_inIDA 13800545PMID:19158400UniProt 
Adcy8Ratcellular response to forskolin involved_inIDA 2312682PMID:13680124UniProt 
Adcy8Ratcellular response to glucagon stimulus involved_inIMP 8553299PMID:21046358UniProt 
Adcy8Ratcellular response to glucagon stimulus involved_inISOAdcy8 (Mus musculus)1624291 PMID:23292513RGDPMID:23292513
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Cellular Component
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Original Reference(s)
Adcy8Ratactin cytoskeleton located_inIDA 13800539PMID:22399809UniProt 
Adcy8Ratapical plasma membrane located_inIEAUniProtKB:P97490 and ensembl:ENSMUSP000000230071600115GO_REF:0000107EnsemblGO_REF:0000107
Adcy8Ratapical plasma membrane located_inISOAdcy8 (Mus musculus)1624291 PMID:14585998RGDPMID:14585998
Adcy8Ratapical plasma membrane located_inIEAUniProtKB-SubCell:SL-00151600115GO_REF:0000044UniProtGO_REF:0000044
Adcy8Ratapical plasma membrane located_inISSUniProtKB:P974901600115GO_REF:0000024UniProtGO_REF:0000024
Adcy8Rataxon located_inISSUniProtKB:P974901600115GO_REF:0000024UniProtGO_REF:0000024
Adcy8Rataxon located_inIEAUniProtKB-SubCell:SL-02791600115GO_REF:0000044UniProtGO_REF:0000044
Adcy8Rataxon located_inISOAdcy8 (Mus musculus)1624291 PMID:14585998RGDPMID:14585998
Adcy8Rataxon located_inIEAUniProtKB:P97490 and ensembl:ENSMUSP000000230071600115GO_REF:0000107EnsemblGO_REF:0000107
Adcy8Ratbasolateral plasma membrane located_inISOAdcy8 (Mus musculus)1624291 PMID:14585998RGDPMID:14585998
Adcy8Ratbasolateral plasma membrane located_inIEAUniProtKB-SubCell:SL-00261600115GO_REF:0000044UniProtGO_REF:0000044
Adcy8Ratbasolateral plasma membrane located_inIEAUniProtKB:P97490 and ensembl:ENSMUSP000000230071600115GO_REF:0000107EnsemblGO_REF:0000107
Adcy8Ratbasolateral plasma membrane located_inISSUniProtKB:P974901600115GO_REF:0000024UniProtGO_REF:0000024
Adcy8Ratcaveola located_inIDA 13800535PMID:11744699UniProt 
Adcy8Ratcaveola located_inIEAUniProtKB-SubCell:SL-00351600115GO_REF:0000044UniProtGO_REF:0000044
Adcy8Ratcell projection located_inIEAUniProtKB-KW:KW-09661600115GO_REF:0000043UniProtGO_REF:0000043
Adcy8Ratclathrin-coated pit located_inIDA 13800545PMID:19158400UniProt 
Adcy8Ratclathrin-coated pit located_inIEAUniProtKB-KW:KW-01681600115GO_REF:0000043UniProtGO_REF:0000043
Adcy8Ratclathrin-coated vesicle membrane located_inIEAUniProtKB-SubCell:SL-00711600115GO_REF:0000044UniProtGO_REF:0000044
Adcy8Ratcytoplasmic vesicle located_inIEAUniProtKB-KW:KW-09681600115GO_REF:0000043UniProtGO_REF:0000043
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Molecular Function
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Original Reference(s)
Adcy8Ratactin binding enablesIDA 13800539PMID:22399809UniProt 
Adcy8Ratadenylate cyclase activity enablesIEAARBA:ARBA000288011600115GO_REF:0000117UniProtGO_REF:0000117
Adcy8Ratadenylate cyclase activity enablesIEAEC:4.6.1.11600115GO_REF:0000003UniProtGO_REF:0000003
Adcy8Ratadenylate cyclase activity enablesIEAUniProtKB:P97490 and ensembl:ENSMUSP000000230071600115GO_REF:0000107EnsemblGO_REF:0000107
Adcy8Ratadenylate cyclase activity enablesIEAInterPro:IPR009398 and InterPro:IPR0306721600115GO_REF:0000002InterProGO_REF:0000002
Adcy8Ratadenylate cyclase activity enablesISOAdcy8 (Mus musculus)1624291MGI:99677 PMID:10482244 and PMID:10799557RGDPMID:10482244 and PMID:10799557
Adcy8Ratadenylate cyclase activity enablesIBAFB:FBgn0003301 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Adcy8Ratadenylate cyclase activity enablesIEAInterPro:IPR0306721600115GO_REF:0000002InterProGO_REF:0000002
Adcy8Ratadenylate cyclase activity enablesIEARHEA:153891600115GO_REF:0000116RHEAGO_REF:0000116
Adcy8RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Adcy8RatATP binding enablesIEAUniRule:UR0007347511600115GO_REF:0000104UniProtGO_REF:0000104
Adcy8Ratcalcium- and calmodulin-responsive adenylate cyclase activity  IDA 69741 RGD 
Adcy8Ratcalcium- and calmodulin-responsive adenylate cyclase activity enablesISOAdcy8 (Mus musculus)1624291 PMID:10864938RGDPMID:10864938
Adcy8Ratcalcium- and calmodulin-responsive adenylate cyclase activity enablesIDA 13825188PMID:8557635UniProt 
Adcy8Ratcalcium- and calmodulin-responsive adenylate cyclase activity enablesIDA 2312682PMID:13680124UniProt 
Adcy8Ratcalcium- and calmodulin-responsive adenylate cyclase activity enablesIDA 13800543PMID:11856299UniProt 
Adcy8Ratcalcium- and calmodulin-responsive adenylate cyclase activity enablesIEAUniProtKB:P97490 and ensembl:ENSMUSP000000230071600115GO_REF:0000107EnsemblGO_REF:0000107
Adcy8Ratcalcium- and calmodulin-responsive adenylate cyclase activity enablesIDA 13800545PMID:19158400UniProt 
Adcy8Ratcalmodulin binding enablesIDA 13800544PMID:16258073UniProt 
Adcy8Ratcalmodulin binding  IDA 7241269 RGD 
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RGD Manual Annotations


  
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Original Reference(s)
Adcy8RatG protein mediated signaling pathway via Galphas family  ISOAdcy8 (Mus musculus)2312469 RGD 
Adcy8Ratprotein kinase A (PKA) signaling pathway   ISOAdcy8 (Mus musculus)2312469 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
Adcy8Ratbile acid transport pathway  IEA 6907045 KEGGrno:04976
Adcy8Ratcalcium/calcium-mediated signaling pathway   IEA 6907045 KEGGrno:04020
Adcy8Ratchemokine mediated signaling pathway  IEA 6907045 KEGGrno:04062
Adcy8Ratdilated cardiomyopathy pathway  IEA 6907045 KEGGrno:05414
Adcy8Ratglutamate signaling pathway  IEA 6907045 KEGGrno:04724
Adcy8Ratgonadotropin-releasing hormone signaling pathway  IEA 6907045 KEGGrno:04912
Adcy8Ratlong term potentiation  IEA 6907045 KEGGrno:04720
Adcy8Ratpurine metabolic pathway  IEA 6907045 KEGGrno:00230

Imported Annotations - PID (archival)

Object Symbol
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Original Reference(s)
Adcy8Ratendothelin signaling pathway  ISOADCY8 (Homo sapiens)6484113 PIDPID:200005

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#
Reference Title
Reference Citation
1. Adenylyl cyclase AC8 directly controls its micro-environment by recruiting the actin cytoskeleton in a cholesterol-rich milieu. Ayling LJ, etal., J Cell Sci. 2012 Feb 15;125(Pt 4):869-86. doi: 10.1242/jcs.091090. Epub 2012 Mar 7.
2. Type VIII adenylyl cyclase. A Ca2+/calmodulin-stimulated enzyme expressed in discrete regions of rat brain. Cali JJ, etal., J Biol Chem 1994 Apr 22;269(16):12190-5.
3. Splice variants of type VIII adenylyl cyclase. Differences in glycosylation and regulation by Ca2+/calmodulin. Cali JJ, etal., J Biol Chem. 1996 Jan 12;271(2):1089-95.
4. PGE2 amplifies the effects of IL-1beta on vascular smooth muscle cell de-differentiation: a consequence of the versatility of PGE2 receptors 3 due to the emerging expression of adenylyl cyclase 8. Clement N, etal., J Cell Physiol. 2006 Sep;208(3):495-505.
5. A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A. Crossthwaite AJ, etal., Mol Pharmacol. 2006 Feb;69(2):608-17. doi: 10.1124/mol.105.018275. Epub 2005 Oct 28.
6. Palmitoylation targets AKAP79 protein to lipid rafts and promotes its regulation of calcium-sensitive adenylyl cyclase type 8. Delint-Ramirez I, etal., J Biol Chem. 2011 Sep 23;286(38):32962-75. doi: 10.1074/jbc.M111.243899. Epub 2011 Jul 19.
7. Type VIII adenylyl cyclase in rat beta cells: coincidence signal detector/generator for glucose and GLP-1. Delmeire D, etal., Diabetologia. 2003 Oct;46(10):1383-93. Epub 2003 Sep 17.
8. Calcium influx activates adenylyl cyclase 8 for sustained insulin secretion in rat pancreatic beta cells. Dou H, etal., Diabetologia. 2015 Feb;58(2):324-33. doi: 10.1007/s00125-014-3437-z. Epub 2014 Nov 9.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Dimerization of mammalian adenylate cyclases. Gu C, etal., Eur J Biochem. 2002 Jan;269(2):413-21.
12. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
13. Separate elements within a single IQ-like motif in adenylyl cyclase type 8 impart ca2+/calmodulin binding and autoinhibition. Macdougall DA, etal., J Biol Chem. 2009 Jun 5;284(23):15573-88. doi: 10.1074/jbc.M809585200. Epub 2009 Mar 21.
14. Capacitative Ca2+ entry via Orai1 and stromal interacting molecule 1 (STIM1) regulates adenylyl cyclase type 8. Martin AC, etal., Mol Pharmacol. 2009 Apr;75(4):830-42. doi: 10.1124/mol.108.051748. Epub 2009 Jan 26.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Insights into the residence in lipid rafts of adenylyl cyclase AC8 and its regulation by capacitative calcium entry. Pagano M, etal., Am J Physiol Cell Physiol. 2009 Mar;296(3):C607-19. doi: 10.1152/ajpcell.00488.2008. Epub 2009 Jan 21.
18. A nuclear location for Ca2+-activated adenylyl cyclases I and III in neurones. Parkinson NA and Bolsover SR, Brain Res Mol Brain Res. 2001 Jul 13;91(1-2):43-9.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
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PMID:10482244   PMID:10864938   PMID:12206999   PMID:12441059   PMID:14585998   PMID:17335981   PMID:18222416   PMID:18448650   PMID:19029295   PMID:22531884   PMID:22613711   PMID:25403481  
PMID:27234425   PMID:29940197   PMID:38291755  



Adcy8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8798,306,434 - 98,555,687 (-)NCBIGRCr8
mRatBN7.2796,417,310 - 96,665,911 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl796,417,324 - 96,665,911 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx798,176,363 - 98,425,655 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07100,377,999 - 100,627,320 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07100,299,283 - 100,548,591 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07105,353,883 - 105,593,372 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7105,353,913 - 105,592,804 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07105,301,826 - 105,541,014 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47101,957,807 - 102,210,346 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17101,992,036 - 102,244,576 (-)NCBI
Celera792,997,741 - 93,245,305 (-)NCBICelera
Cytogenetic Map7q33NCBI
ADCY8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388130,780,301 - 131,040,909 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8130,780,301 - 131,040,909 (-)EnsemblGRCh38hg38GRCh38
GRCh378131,792,547 - 132,053,155 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368131,861,729 - 132,123,854 (-)NCBINCBI36Build 36hg18NCBI36
Build 348131,861,728 - 132,123,854NCBI
Celera8127,969,937 - 128,230,969 (-)NCBICelera
Cytogenetic Map8q24.22NCBI
HuRef8127,112,105 - 127,216,470 (-)NCBIHuRef
HuRef8127,235,506 - 127,372,263 (-)NCBIHuRef
CHM1_18131,833,662 - 132,093,872 (-)NCBICHM1_1
T2T-CHM13v2.08131,907,547 - 132,167,269 (-)NCBIT2T-CHM13v2.0
Adcy8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391564,570,884 - 64,794,145 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1564,568,933 - 64,794,145 (-)EnsemblGRCm39 Ensembl
GRCm381564,699,035 - 64,922,296 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1564,697,084 - 64,922,296 (-)EnsemblGRCm38mm10GRCm38
MGSCv371564,530,597 - 64,753,858 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361564,528,707 - 64,751,833 (-)NCBIMGSCv36mm8
Celera1566,221,302 - 66,448,865 (-)NCBICelera
Cytogenetic Map15D1NCBI
cM Map1529.03NCBI
Adcy8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554615,497,628 - 5,725,574 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554615,497,708 - 5,725,574 (-)NCBIChiLan1.0ChiLan1.0
ADCY8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27148,150,875 - 148,412,746 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18123,667,241 - 123,929,157 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08127,418,407 - 127,681,217 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18130,399,223 - 130,661,073 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8130,398,288 - 130,661,073 (-)Ensemblpanpan1.1panPan2
ADCY8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11327,723,530 - 27,937,821 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1327,723,530 - 27,937,734 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1327,690,009 - 27,910,417 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01328,068,919 - 28,289,497 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1328,068,921 - 28,289,497 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11327,784,095 - 28,006,367 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01327,904,105 - 28,118,318 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01328,205,442 - 28,426,573 (-)NCBIUU_Cfam_GSD_1.0
Adcy8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530310,405,531 - 10,621,769 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647017,831,639 - 18,047,868 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647017,831,644 - 18,047,868 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADCY8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl49,645,659 - 9,866,550 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.149,645,398 - 9,867,065 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.249,777,859 - 9,968,857 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADCY8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18125,269,396 - 125,535,806 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8125,269,736 - 125,533,015 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603914,582,569 - 14,845,878 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adcy8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473524,891,583 - 25,149,900 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473524,891,803 - 25,149,817 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Adcy8
1104 total Variants

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:64
Interacting mature miRNAs:67
Transcripts:ENSRNOT00000006789
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 39 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat

1 to 10 of 39 rows
AW060868  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2796,417,524 - 96,417,616 (+)MAPPERmRatBN7.2
Rnor_6.07105,354,114 - 105,354,205NCBIRnor6.0
Rnor_5.07105,302,057 - 105,302,148UniSTSRnor5.0
RGSC_v3.47101,958,022 - 101,958,113UniSTSRGSC3.4
Celera792,997,954 - 92,998,045UniSTS
Cytogenetic Map7q33UniSTS
UniSTS:546632  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2796,665,028 - 96,665,927 (+)MAPPERmRatBN7.2
Rnor_6.07105,591,922 - 105,592,820NCBIRnor6.0
Rnor_5.07105,539,569 - 105,540,467UniSTSRnor5.0
Celera793,244,423 - 93,245,321UniSTS
Cytogenetic Map7q33UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 7 23 113 46 40 20 3 20 6 98 40 93 25 47 20



Ensembl Acc Id: ENSRNOT00000006789   ⟹   ENSRNOP00000006789
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl796,417,324 - 96,665,911 (-)Ensembl
Rnor_6.0 Ensembl7105,353,913 - 105,592,804 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096414   ⟹   ENSRNOP00000085627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl796,417,324 - 96,665,911 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098906   ⟹   ENSRNOP00000086009
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl796,417,324 - 96,665,911 (-)Ensembl
RefSeq Acc Id: NM_017142   ⟹   NP_058838
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8798,306,450 - 98,555,038 (-)NCBI
mRatBN7.2796,417,310 - 96,665,911 (-)NCBI
Rnor_6.07105,353,899 - 105,592,804 (-)NCBI
Rnor_5.07105,301,826 - 105,541,014 (-)NCBI
RGSC_v3.47101,957,807 - 102,210,346 (-)RGD
Celera792,997,741 - 93,245,305 (-)RGD
Sequence:
RefSeq Acc Id: XM_006241703   ⟹   XP_006241765
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8798,306,434 - 98,555,685 (-)NCBI
mRatBN7.2796,417,388 - 96,665,135 (-)NCBI
Rnor_6.07105,353,883 - 105,593,372 (-)NCBI
Rnor_5.07105,301,826 - 105,541,014 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006241704   ⟹   XP_006241766
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8798,306,434 - 98,555,686 (-)NCBI
mRatBN7.2796,417,388 - 96,665,135 (-)NCBI
Rnor_6.07105,353,883 - 105,593,372 (-)NCBI
Rnor_5.07105,301,826 - 105,541,014 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039078563   ⟹   XP_038934491
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8798,306,434 - 98,555,685 (-)NCBI
mRatBN7.2796,417,381 - 96,665,234 (-)NCBI
RefSeq Acc Id: XM_039078564   ⟹   XP_038934492
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8798,306,434 - 98,555,686 (-)NCBI
mRatBN7.2796,417,381 - 96,665,234 (-)NCBI
RefSeq Acc Id: XM_039078565   ⟹   XP_038934493
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8798,306,434 - 98,555,687 (-)NCBI
mRatBN7.2796,417,381 - 96,665,234 (-)NCBI
RefSeq Acc Id: XM_039078567   ⟹   XP_038934495
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8798,306,434 - 98,555,687 (-)NCBI
mRatBN7.2796,417,381 - 96,665,234 (-)NCBI
RefSeq Acc Id: XM_063263112   ⟹   XP_063119182
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8798,306,434 - 98,555,686 (-)NCBI
1 to 5 of 11 rows
1 to 5 of 11 rows
RefSeq Acc Id: NP_058838   ⟸   NM_017142
- UniProtKB: P40146 (UniProtKB/Swiss-Prot),   A6HRQ4 (UniProtKB/TrEMBL),   G3V6N0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241766   ⟸   XM_006241704
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A3U3 (UniProtKB/TrEMBL),   A6HRQ4 (UniProtKB/TrEMBL),   G3V6N0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241765   ⟸   XM_006241703
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GDK4 (UniProtKB/TrEMBL),   A6HRQ4 (UniProtKB/TrEMBL),   G3V6N0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006789   ⟸   ENSRNOT00000006789
RefSeq Acc Id: XP_038934495   ⟸   XM_039078567
- Peptide Label: isoform X7
- UniProtKB: A0A2Z4LIN0 (UniProtKB/TrEMBL)
Guanylate cyclase

Name Modeler Protein Id AA Range Protein Structure
AF-P40146-F1-model_v2 AlphaFold P40146 1-1248 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 39 of 39 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-33140 BioCyc
Ensembl Genes ENSRNOG00000004890 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000006789 ENTREZGENE
  ENSRNOT00000096414 ENTREZGENE
  ENSRNOT00000098906 ENTREZGENE
Gene3D-CATH 3.30.70.1230 UniProtKB/Swiss-Prot
InterPro A/G_cyclase UniProtKB/Swiss-Prot
  A/G_cyclase_CS UniProtKB/Swiss-Prot
  AC_N UniProtKB/Swiss-Prot
  Adcy UniProtKB/Swiss-Prot
  Adcy_conserved_dom UniProtKB/Swiss-Prot
  Nucleotide_cyclase UniProtKB/Swiss-Prot
KEGG Report rno:29241 UniProtKB/Swiss-Prot
NCBI Gene 29241 ENTREZGENE
PANTHER ADENYLATE CYCLASE TYPE 1 UniProtKB/Swiss-Prot
  ADENYLATE CYCLASE TYPE 8 UniProtKB/Swiss-Prot
Pfam AC_N UniProtKB/Swiss-Prot
  DUF1053 UniProtKB/Swiss-Prot
  Guanylate_cyc UniProtKB/Swiss-Prot
PharmGKB ADCY8 RGD
PhenoGen Adcy8 PhenoGen
PIRSF Ade_cyc UniProtKB/Swiss-Prot
PROSITE GUANYLATE_CYCLASE_1 UniProtKB/Swiss-Prot
  GUANYLATE_CYCLASE_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004890 RatGTEx
SMART CYCc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55073 UniProtKB/Swiss-Prot
TIGR TC207966
UniProt A0A2Z4LIM7 ENTREZGENE, UniProtKB/TrEMBL
  A0A2Z4LIN0 ENTREZGENE, UniProtKB/TrEMBL
  A0A2Z4LIN1 ENTREZGENE, UniProtKB/TrEMBL
  A0A2Z4LIN4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A3U3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GDK4 ENTREZGENE, UniProtKB/TrEMBL
  A6HRQ3_RAT UniProtKB/TrEMBL
  A6HRQ4 ENTREZGENE, UniProtKB/TrEMBL
  ADCY8_RAT UniProtKB/Swiss-Prot
  G3V6N0 ENTREZGENE, UniProtKB/TrEMBL
  P40146 ENTREZGENE
1 to 39 of 39 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-29 Adcy8  adenylate cyclase 8  Adcy8  adenylate cyclase 8 (brain)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Adcy8  adenylate cyclase 8 (brain)  Adcy8  adenylate cyclase 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Adcy8  adenylate cyclase 8    adenylyl cyclase 8  Name updated 1299863 APPROVED
2002-06-10 Adcy8  adenylyl cyclase 8      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_expression expressed in several regions in brain 69741
gene_function has adenylyl cyclase activity that is induced by intracellular calcium/calmodulin 69741
gene_process may play a role in intracellular signaling and long term potentiation 69741
gene_regulation activity is induced by calcuim/calmodulin 69741
gene_regulation induction by calcium/calmodulin is enhanced by addition of Gs alpha 69741
gene_transcript mRNA transcripts of 4.4 and 5.5 kB are detected 69741