Actg2 (actin gamma 2, smooth muscle) - Rat Genome Database

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Gene: Actg2 (actin gamma 2, smooth muscle) Rattus norvegicus
Analyze
Symbol: Actg2
Name: actin gamma 2, smooth muscle
RGD ID: 2027
Description: Predicted to enable ATP binding activity; hydrolase activity; and protein kinase binding activity. Predicted to be involved in mesenchyme migration and positive regulation of gene expression. Predicted to be located in several cellular components, including filopodium; lamellipodium; and myosin filament. Predicted to be part of protein-containing complex. Predicted to be active in actin cytoskeleton. Human ortholog(s) of this gene implicated in megacystis-microcolon-intestinal hypoperistalsis syndrome. Orthologous to human ACTG2 (actin gamma 2, smooth muscle); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ACTGE; Actin gamma 2 smooth muscle enteric; actin, gamma 2; actin, gamma 2, smooth muscle, enteric; actin, gamma-enteric smooth muscle; alpha-actin-3; alpha-smooth muscle actin; gamma-2-actin; gamma-enteric smooth muscle actin; MGC105507; SMGA; smooth muscle gamma-actin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84117,579,513 - 117,604,379 (-)NCBIGRCr8
mRatBN7.24116,021,832 - 116,046,475 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4116,021,832 - 116,046,465 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4121,500,276 - 121,514,993 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04117,275,441 - 117,290,158 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04115,889,059 - 115,903,778 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04115,215,160 - 115,239,746 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4115,215,060 - 115,239,723 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04179,805,782 - 179,830,362 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44117,732,482 - 117,747,006NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4105,015,569 - 105,030,100 (-)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Actg2Ratautosomal dominant familial visceral neuropathy  ISOACTG2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11474115 more ...
Actg2Ratcongenital disorder of glycosylation type IIb  ISOACTG2 (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital disorder of glycosylation type 2BClinVarPMID:24716661 more ...
Actg2Ratdystonia  ISOACTG2 (Homo sapiens)8554872ClinVar Annotator: match by term: DystoniaClinVarPMID:16697227 more ...
Actg2Ratgenetic disease  ISOACTG2 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:11474115 more ...
Actg2Ratintestinal obstruction  ISOACTG2 (Homo sapiens)8554872ClinVar Annotator: match by term: Intestinal obstructionClinVarPMID:22960657 more ...
Actg2Ratintestinal pseudo-obstruction  ISOACTG2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11474115 more ...
Actg2Ratmegacystis-microcolon-intestinal hypoperistalsis syndrome  ISOACTG2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11474115 more ...
Actg2RatMegacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 5  ISOACTG2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11474115 more ...
Actg2RatMegaduodenum  ISOACTG2 (Homo sapiens)8554872ClinVar Annotator: match by term: MegacystisClinVarPMID:23806086 more ...
Actg2RatMethylmalonyl-CoA Epimerase Deficiency  ISOACTG2 (Homo sapiens)8554872ClinVar Annotator: match by term: METHYLMALONIC ACIDURIA IIIClinVarPMID:16697227 more ...
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Object Symbol
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Evidence
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Reference
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Source
Original Reference(s)
Actg2RatColonic Neoplasms  ISOACTG2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15059925
Actg2RatFamilial Visceral Myopathy  ISOACTG2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22960657
Actg2Ratmegacystis-microcolon-intestinal hypoperistalsis syndrome  ISOACTG2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24337657 and PMID:24676022
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Actg2Ratmegacystis-microcolon-intestinal hypoperistalsis syndrome  ISSActg2 (Mus musculus)13592920OMIM:155310MouseDO 

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Object Symbol
Species
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Reference
Notes
Source
Original Reference(s)
Actg2Rat1,2-dimethylhydrazine multiple interactionsEXP 6480464[APC protein affects the susceptibility to 1 and 2-Dimethylhydrazine] which results in increased expression of ACTG2 mRNACTDPMID:27840820
Actg2Rat1,2-dimethylhydrazine increases expressionISOActg2 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of ACTG2 mRNACTDPMID:22206623
Actg2Rat1,2-dimethylhydrazine multiple interactionsISOActg2 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of ACTG2 mRNACTDPMID:22206623
Actg2Rat17alpha-ethynylestradiol increases expressionISOActg2 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of ACTG2 mRNACTDPMID:17942748
Actg2Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of ACTG2 mRNACTDPMID:12655037 and PMID:15576828
Actg2Rat17alpha-ethynylestradiol multiple interactionsISOActg2 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACTG2 mRNACTDPMID:17942748
Actg2Rat17beta-estradiol decreases expressionISOACTG2 (Homo sapiens)6480464Estradiol results in decreased expression of ACTG2 mRNACTDPMID:25878060
Actg2Rat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of ACTG2 mRNACTDPMID:32145629
Actg2Rat17beta-estradiol multiple interactionsEXP 6480464[bisphenol A co-treated with Estradiol] results in decreased expression of ACTG2 mRNACTDPMID:26496021
Actg2Rat2,2',5,5'-tetrachlorobiphenyl decreases expressionISOACTG2 (Homo sapiens)64804642 more ...CTDPMID:36804509
Actg2Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOActg2 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACTG2 mRNACTDPMID:17942748
Actg2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of ACTG2 mRNACTDPMID:32109520 and PMID:34747641
Actg2Rat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642 more ...CTDPMID:32109520
Actg2Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether decreases expressionISOActg2 (Mus musculus)64804642 more ...CTDPMID:18550172
Actg2Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether increases expressionISOActg2 (Mus musculus)64804642 more ...CTDPMID:18550172
Actg2Rat2-nitrotoluene decreases expressionEXP 64804642-nitrotoluene results in decreased expression of ACTG2 mRNACTDPMID:16460773
Actg2Rat3,3',4,4',5-pentachlorobiphenyl decreases expressionEXP 64804643 more ...CTDPMID:32119087
Actg2Rat3,7-dihydropurine-6-thione decreases expressionEXP 6480464Mercaptopurine results in decreased expression of ACTG2 mRNACTDPMID:23358152
Actg2Rat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOActg2 (Mus musculus)6480464[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ACTG2 mRNACTDPMID:16054899
Actg2Rat4,4'-sulfonyldiphenol multiple interactionsISOActg2 (Mus musculus)6480464[bisphenol S co-treated with Tretinoin] results in decreased expression of ACTG2 mRNACTDPMID:30951980

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Biological Process

  
Object Symbol
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Reference
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Original Reference(s)
Actg2Ratbiological_process  ND 159840712/2014: no relevant rat dataRGD 
Actg2Ratglomerular mesangial cell development involved_inIEAUniProtKB:P62736 and ensembl:ENSP000002247841600115GO_REF:0000107EnsemblGO_REF:0000107
Actg2Ratmesenchyme migration involved_inISSUniProtKB:P080231600115GO_REF:0000024AgBaseGO_REF:0000024
Actg2Ratpositive regulation of gene expression involved_inISSUniProtKB:P080231600115GO_REF:0000024AgBaseGO_REF:0000024
Actg2Ratregulation of blood pressure acts_upstream_of_or_withinIEAUniProtKB:P62737 and ensembl:ENSMUSP000000482181600115GO_REF:0000107EnsemblGO_REF:0000107
Actg2Ratresponse to virus involved_inIEAUniProtKB:P62736 and ensembl:ENSP000002247841600115GO_REF:0000107EnsemblGO_REF:0000107
Actg2Ratvascular associated smooth muscle contraction acts_upstream_of_or_withinIEAUniProtKB:P62737 and ensembl:ENSMUSP000000482181600115GO_REF:0000107EnsemblGO_REF:0000107

Cellular Component
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Object Symbol
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Original Reference(s)
Actg2Ratactin cytoskeleton located_inIEAUniProtKB:P62737 and ensembl:ENSMUSP000000482181600115GO_REF:0000107EnsemblGO_REF:0000107
Actg2Ratactin cytoskeleton is_active_inIBACGD:CAL0000191211 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Actg2Ratcell body located_inISSUniProtKB:P080231600115GO_REF:0000024AgBaseGO_REF:0000024
Actg2Ratcell periphery located_inISOActg2 (Mus musculus)1624291 PMID:12040017RGDPMID:12040017
Actg2Ratcell periphery located_inIEAUniProtKB:P63268 and ensembl:ENSMUSP000000746581600115GO_REF:0000107EnsemblGO_REF:0000107
Actg2Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Actg2Ratcytoplasm located_inIEAUniProtKB:P62736 and ensembl:ENSP000002247841600115GO_REF:0000107EnsemblGO_REF:0000107
Actg2Ratcytoplasm located_inISSUniProtKB:P080231600115GO_REF:0000024AgBaseGO_REF:0000024
Actg2Ratcytoplasm located_inIEAUniProtKB:P62737 and ensembl:ENSMUSP000000482181600115GO_REF:0000107EnsemblGO_REF:0000107
Actg2Ratcytoskeleton located_inIEAUniProtKB-SubCell:SL-00901600115GO_REF:0000044UniProtGO_REF:0000044
Actg2Ratcytoskeleton located_inIEAUniProtKB-KW:KW-02061600115GO_REF:0000043UniProtGO_REF:0000043
Actg2Ratcytoskeleton located_inIEAUniProtKB:P62737 and ensembl:ENSMUSP000000482181600115GO_REF:0000107EnsemblGO_REF:0000107
Actg2Ratfilopodium located_inISSUniProtKB:P080231600115GO_REF:0000024AgBaseGO_REF:0000024
Actg2Ratlamellipodium located_inISSUniProtKB:P080231600115GO_REF:0000024AgBaseGO_REF:0000024
Actg2Ratmotile cilium located_inIEAUniProtKB:P62737 and ensembl:ENSMUSP000000482181600115GO_REF:0000107EnsemblGO_REF:0000107
Actg2Ratmyosin filament located_inISSUniProtKB:F1P4761600115GO_REF:0000024AgBaseGO_REF:0000024
Actg2Ratprotein-containing complex part_ofIEAUniProtKB:P62736 and ensembl:ENSP000002247841600115GO_REF:0000107EnsemblGO_REF:0000107
Actg2Ratsmooth muscle contractile fiber located_inIEAUniProtKB:P62737 and ensembl:ENSMUSP000000482181600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function

  
Object Symbol
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Term
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Evidence
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Reference
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Source
Original Reference(s)
Actg2RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Actg2Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Actg2Ratnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Actg2Ratprotein kinase binding enablesIEAUniProtKB:P62737 and ensembl:ENSMUSP000000482181600115GO_REF:0000107EnsemblGO_REF:0000107


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#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. The development expression of the rat alpha-vascular and gamma-enteric smooth muscle isoactins: isolation and characterization of a rat gamma-enteric actin cDNA. McHugh KM and Lessard JL, Mol Cell Biol 1988 Dec;8(12):5224-31.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. [Complex evaluation of the health status indicators of military personnel]. Poliakov LE, etal., Voen Med Zh. 1978 Nov;(11):15-20.
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
12. Polski tygodnik lekarski (Warsaw, Poland : 1960) Woyton A Pol Tyg Lek 1978 Aug 7;33(32):1263-4.
1 to 12 of 12 rows
PMID:3597426   PMID:12040017   PMID:12477932   PMID:12482893   PMID:15489334   PMID:15591055   PMID:15972885   PMID:16259921   PMID:16493181   PMID:16533564   PMID:19797053   PMID:22165288  
PMID:22516433   PMID:23533145   PMID:23580065   PMID:25002582   PMID:29476059   PMID:31484043  



Actg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84117,579,513 - 117,604,379 (-)NCBIGRCr8
mRatBN7.24116,021,832 - 116,046,475 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4116,021,832 - 116,046,465 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4121,500,276 - 121,514,993 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04117,275,441 - 117,290,158 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04115,889,059 - 115,903,778 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04115,215,160 - 115,239,746 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4115,215,060 - 115,239,723 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04179,805,782 - 179,830,362 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44117,732,482 - 117,747,006NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4105,015,569 - 105,030,100 (-)NCBICelera
Cytogenetic Map4q34NCBI
ACTG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38273,893,008 - 73,919,865 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl273,892,314 - 73,919,865 (+)EnsemblGRCh38hg38GRCh38
GRCh37274,120,135 - 74,146,992 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36273,973,601 - 74,000,288 (+)NCBINCBI36Build 36hg18NCBI36
Build 34274,031,789 - 74,058,434NCBI
Celera273,951,347 - 73,978,043 (+)NCBICelera
Cytogenetic Map2p13.1NCBI
HuRef273,854,905 - 73,882,444 (+)NCBIHuRef
CHM1_1274,049,434 - 74,076,040 (+)NCBICHM1_1
T2T-CHM13v2.0273,901,172 - 73,928,327 (+)NCBIT2T-CHM13v2.0
Actg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,489,891 - 83,513,233 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl683,489,887 - 83,513,247 (-)EnsemblGRCm39 Ensembl
GRCm38683,512,909 - 83,536,251 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,512,905 - 83,536,265 (-)EnsemblGRCm38mm10GRCm38
MGSCv37683,462,903 - 83,486,245 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36683,478,568 - 83,501,883 (-)NCBIMGSCv36mm8
Celera685,494,063 - 85,517,393 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
Actg2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542411,779,597 - 11,802,446 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542411,779,805 - 11,802,446 (-)NCBIChiLan1.0ChiLan1.0
ACTG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21252,464,021 - 52,490,974 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A52,466,775 - 52,493,728 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A73,966,939 - 73,993,862 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A75,476,877 - 75,503,658 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A75,476,877 - 75,503,658 (+)Ensemblpanpan1.1panPan2
ACTG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11749,144,184 - 49,168,872 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1749,104,546 - 49,168,782 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1748,784,850 - 48,810,117 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01750,003,715 - 50,028,411 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1750,003,722 - 50,028,328 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11749,019,875 - 49,044,569 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01749,087,331 - 49,111,998 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01749,645,142 - 49,670,439 (-)NCBIUU_Cfam_GSD_1.0
Actg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629210,517,808 - 10,563,374 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936556174,602 - 220,285 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936556174,602 - 220,088 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACTG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl369,096,782 - 69,121,351 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1369,097,366 - 69,121,542 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2372,251,872 - 72,257,786 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACTG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11433,363,170 - 33,390,710 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1433,363,023 - 33,390,937 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604578,776,828 - 78,804,281 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Actg2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474929,566,380 - 29,588,705 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474929,566,613 - 29,588,572 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Actg2
273 total Variants

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:51
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000042699
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)478881294117676292Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat

1 to 10 of 51 rows
PMC20960P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21211,665,621 - 11,665,967 (+)MAPPERmRatBN7.2
Rnor_6.01213,718,353 - 13,718,698NCBIRnor6.0
Rnor_5.01215,748,366 - 15,748,711UniSTSRnor5.0
RGSC_v3.41212,049,580 - 12,049,925UniSTSRGSC3.4
Celera1213,454,953 - 13,455,298UniSTS
Cytogenetic Map12p11UniSTS
Cytogenetic Map4q34UniSTS
STS_ADH2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23100,812,851 - 100,813,988 (+)MAPPERmRatBN7.2
mRatBN7.2437,621,193 - 37,621,465 (+)MAPPERmRatBN7.2
Rnor_6.0435,593,637 - 35,593,908NCBIRnor6.0
Rnor_6.03105,508,268 - 105,509,404NCBIRnor6.0
Rnor_5.0435,451,038 - 35,451,309UniSTSRnor5.0
Rnor_5.03112,081,718 - 112,082,854UniSTSRnor5.0
RGSC_v3.4399,901,887 - 99,903,023UniSTSRGSC3.4
RGSC_v3.4434,652,200 - 34,652,471UniSTSRGSC3.4
Celera433,105,107 - 33,105,378UniSTS
Celera399,782,375 - 99,783,511UniSTS
Cytogenetic Map3q35UniSTS
Cytogenetic Map4q21UniSTS
Cytogenetic Map4q34UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 111 91 90 59 25 59 6 218 97 91 45 60 31



Ensembl Acc Id: ENSRNOT00000042699   ⟹   ENSRNOP00000050322
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4116,021,832 - 116,046,465 (-)Ensembl
Rnor_6.0 Ensembl4115,215,060 - 115,239,723 (-)Ensembl
RefSeq Acc Id: NM_012893   ⟹   NP_037025
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,579,513 - 117,594,039 (-)NCBI
mRatBN7.24116,021,832 - 116,036,358 (-)NCBI
Rnor_6.04115,215,160 - 115,229,684 (-)NCBI
Rnor_5.04179,805,782 - 179,830,362 (-)NCBI
RGSC_v3.44117,732,482 - 117,747,006 (-)RGD
Celera4105,015,569 - 105,030,100 (-)RGD
Sequence:
RefSeq Acc Id: XM_006236728   ⟹   XP_006236790
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,579,513 - 117,604,379 (-)NCBI
mRatBN7.24116,021,832 - 116,046,475 (-)NCBI
Rnor_6.04115,215,160 - 115,239,746 (-)NCBI
Rnor_5.04179,805,782 - 179,830,362 (-)NCBI
Sequence:
1 to 9 of 9 rows
Protein RefSeqs NP_037025 (Get FASTA)   NCBI Sequence Viewer  
  XP_006236790 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40672 (Get FASTA)   NCBI Sequence Viewer  
  AAH87689 (Get FASTA)   NCBI Sequence Viewer  
  EDL91149 (Get FASTA)   NCBI Sequence Viewer  
  EDL91150 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000050322
  ENSRNOP00000050322.2
GenBank Protein P63269 (Get FASTA)   NCBI Sequence Viewer  
1 to 9 of 9 rows
RefSeq Acc Id: NP_037025   ⟸   NM_012893
- UniProtKB: P63269 (UniProtKB/Swiss-Prot),   A6IAN1 (UniProtKB/TrEMBL),   A0A0G2K4M6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236790   ⟸   XM_006236728
- Peptide Label: isoform X1
- UniProtKB: P63269 (UniProtKB/Swiss-Prot),   A6IAN1 (UniProtKB/TrEMBL),   A0A0G2K4M6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000050322   ⟸   ENSRNOT00000042699

Name Modeler Protein Id AA Range Protein Structure
AF-P63269-F1-model_v2 AlphaFold P63269 1-376 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693181
Promoter ID:EPDNEW_R3705
Type:multiple initiation site
Name:Actg2_1
Description:actin, gamma 2, smooth muscle, enteric
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04115,239,689 - 115,239,749EPDNEW


1 to 31 of 31 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-44003 BioCyc
Ensembl Genes ENSRNOG00000029401 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000042699 ENTREZGENE
  ENSRNOT00000042699.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.420.40 UniProtKB/Swiss-Prot
  Actin, Chain A, domain 4 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7310913 IMAGE-MGC_LOAD
InterPro Actin UniProtKB/Swiss-Prot
  Actin/actin-like_CS UniProtKB/Swiss-Prot
  Actin_CS UniProtKB/Swiss-Prot
  ATPase_NBD UniProtKB/Swiss-Prot
KEGG Report rno:25365 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105507 IMAGE-MGC_LOAD
NCBI Gene 25365 ENTREZGENE
PANTHER PTHR11937 UniProtKB/Swiss-Prot
Pfam Actin UniProtKB/Swiss-Prot
PhenoGen Actg2 PhenoGen
PRINTS ACTIN UniProtKB/Swiss-Prot
PROSITE ACTINS_1 UniProtKB/Swiss-Prot
  ACTINS_2 UniProtKB/Swiss-Prot
  ACTINS_ACT_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000029401 RatGTEx
  ENSRNOG00000058039 RatGTEx
SMART ACTIN UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53067 UniProtKB/Swiss-Prot
TIGR TC217240
UniProt A0A0G2K4M6 ENTREZGENE, UniProtKB/TrEMBL
  A6IAN1 ENTREZGENE, UniProtKB/TrEMBL
  A6IAN2_RAT UniProtKB/TrEMBL
  ACTH_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P12718 UniProtKB/Swiss-Prot
1 to 31 of 31 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-03-25 Actg2  actin gamma 2, smooth muscle  Actg2  actin, gamma 2, smooth muscle, enteric  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-14 Actg2  actin, gamma 2, smooth muscle, enteric  Actg2  actin, gamma 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Actg2  actin, gamma 2    Actin, gamma 2, smooth muscle, enteric  Name updated 625702 APPROVED
2002-06-10 Actg2  Actin, gamma 2, smooth muscle, enteric      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_expression expressed in stomach smooth muscle 631723
gene_homology mature protein is nearly identical to that of the chicken gizzard gamma actin sequence with one differing amino acid 631723
gene_product member of the actin family 631723