Acta1 (actin, alpha 1, skeletal muscle) - Rat Genome Database

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Gene: Acta1 (actin, alpha 1, skeletal muscle) Rattus norvegicus
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Symbol: Acta1
Name: actin, alpha 1, skeletal muscle
RGD ID: 2025
Description: Predicted to enable ATP binding activity; hydrolase activity; and protein kinase binding activity. Involved in several processes, including cellular response to potassium ion; response to steroid hormone; and skeletal muscle fiber adaptation. Predicted to be located in several cellular components, including filopodium; lamellipodium; and sarcomere. Predicted to be part of protein-containing complex. Predicted to be active in actin filament; stress fiber; and striated muscle thin filament. Human ortholog(s) of this gene implicated in congenital myopathy 2B; congenital myopathy 2C; and nemaline myopathy 3. Orthologous to human ACTA1 (actin alpha 1, skeletal muscle); INTERACTS WITH (+)-schisandrin B; (R)-noradrenaline; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: actin alpha 1; actin alpha 1 skeletal muscle; actin, alpha skeletal muscle; alpha-actin-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81968,781,168 - 68,784,194 (-)NCBIGRCr8
mRatBN7.21951,883,709 - 51,886,735 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1951,883,715 - 51,886,742 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1958,675,301 - 58,678,329 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01959,519,721 - 59,522,747 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01961,601,732 - 61,604,760 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01956,674,072 - 56,677,084 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1956,674,074 - 56,677,084 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01967,389,899 - 67,392,911 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41954,081,496 - 54,084,508 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11954,086,370 - 54,089,389 (-)NCBI
Celera1951,258,256 - 51,261,324 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
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Original Reference(s)
Acta1Rataortic dissection  ISOACTA1 (Homo sapiens)155260287protein:decreased expression:aorta (human)RGD 
Acta1RatKidney Reperfusion Injury amelioratesISOActa1 (Mus musculus)329845564 RGD 
Acta1RatVentricular Fibrillation  IEP 1598720 RGD 
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Acta1RatActin-Accumulation Myopathy  ISOACTA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Actin accumulation myopathyClinVarPMID:10508519 more ...
Acta1Ratcentronuclear myopathy  ISOACTA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Centronuclear myopathyClinVarPMID:25741868 and PMID:32668698
Acta1Ratcongenital myopathy  ISOACTA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital myopathyClinVarPMID:21520333 more ...
Acta1Ratcongenital myopathy 2B  ISOACTA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital myopathy 2b more ...ClinVarPMID:10508519 more ...
Acta1Ratcongenital myopathy 2C  ISOACTA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital myopathy 2c more ...ClinVarPMID:10508519 more ...
Acta1Ratcongenital myopathy 4A  ISOACTA1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10508519 more ...
Acta1Ratcongenital structural myopathy  ISOACTA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital fiber-type disproportion myopathyClinVarPMID:10508519 more ...
Acta1Ratdilated cardiomyopathy  ISOACTA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Primary dilated cardiomyopathyClinVarPMID:25741868 more ...
Acta1Ratfetal akinesia deformation sequence syndrome  ISOACTA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Fetal akinesia deformation sequenceClinVarPMID:25741868 and PMID:33060286
Acta1Ratfetal akinesia deformation sequence syndrome 1  ISOACTA1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:19562689 more ...
Acta1Ratgastrointestinal stromal tumor  ISOACTA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
Acta1Ratgenetic disease  ISOACTA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:12921789 more ...
Acta1RatHydrops Fetalis  ISOACTA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Non-immune hydrops fetalisClinVarPMID:25741868
Acta1RatIntranuclear Rod Myopathy  ISOACTA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Intranuclear rod myopathyClinVarPMID:24787270 more ...
Acta1Ratmyopathy  ISOACTA1 (Homo sapiens)8554872ClinVar Annotator: match by term: MyopathyClinVarPMID:25741868 more ...
Acta1RatMyopathy, Actin, Congenital, with Excess of Thin Myofilaments  ISOACTA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Myopathy more ...ClinVarPMID:10508519 more ...
Acta1Ratnemaline myopathy  ISOACTA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Nemaline myopathyClinVarPMID:19562689 more ...
Acta1Ratnemaline myopathy 2  ISOACTA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Nemaline myopathy 2 and autosomal recessiveClinVarPMID:12921789 more ...
Acta1Ratnemaline myopathy 3  ISOACTA1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10508519 more ...
Acta1Ratneuromuscular disease  ISOACTA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Neuromuscular diseaseClinVarPMID:12921789 more ...
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Acta1RatLeft Ventricular Hypertrophy  ISOACTA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:10601118
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Acta1Ratnemaline myopathy 3  ISSActa1 (Mus musculus)13592920OMIM:161800MouseDO 

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Original Reference(s)
Acta1Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA1 mRNA]CTDPMID:31150632
Acta1Rat(R)-noradrenaline increases expressionEXP 6480464Norepinephrine results in increased expression of ACTA1 mRNACTDPMID:17592507
Acta1Rat(S)-nicotine increases expressionISOActa1 (Mus musculus)6480464Nicotine results in increased expression of ACTA1 mRNACTDPMID:17997037
Acta1Rat(S)-nicotine decreases expressionEXP 6480464Nicotine results in decreased expression of ACTA1 mRNACTDPMID:27782041
Acta1Rat1,2-dimethylhydrazine multiple interactionsISOActa1 (Mus musculus)6480464Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of ACTA1 mRNA]CTDPMID:22206623
Acta1Rat1,2-dimethylhydrazine increases expressionISOActa1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of ACTA1 mRNACTDPMID:22206623
Acta1Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of ACTA1 mRNACTDPMID:30723492
Acta1Rat17beta-estradiol decreases expressionISOActa1 (Mus musculus)6480464Estradiol results in decreased expression of ACTA1 mRNACTDPMID:19484750
Acta1Rat17beta-estradiol increases expressionISOActa1 (Mus musculus)6480464Estradiol results in increased expression of ACTA1 mRNACTDPMID:39298647
Acta1Rat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of ACTA1 mRNACTDPMID:32145629
Acta1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of ACTA1 mRNACTDPMID:19692669 and PMID:32109520
Acta1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of ACTA1 mRNACTDPMID:34747641
Acta1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOActa1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of ACTA1 mRNACTDPMID:26377647
Acta1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOACTA1 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of ACTA1 mRNACTDPMID:26238291
Acta1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOActa1 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of ACTA1 mRNACTDPMID:15591033 and PMID:19770486
Acta1Rat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642 more ...CTDPMID:32109520
Acta1Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOActa1 (Mus musculus)64804642 more ...CTDPMID:38648751
Acta1Rat3,3',4,4',5-pentachlorobiphenyl decreases expressionEXP 64804643 more ...CTDPMID:19692669
Acta1Rat3,3',4,4',5-pentachlorobiphenyl increases expressionEXP 64804643 more ...CTDPMID:32119087
Acta1Rat3-methylcholanthrene decreases expressionISOActa1 (Mus musculus)6480464Methylcholanthrene results in decreased expression of ACTA1 mRNACTDPMID:29554273

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Biological Process
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Original Reference(s)
Acta1Ratcellular response to potassium ion  IEP 1598717 RGD 
Acta1Ratglomerular mesangial cell development involved_inIEAUniProtKB:P62736 and ensembl:ENSP000002247841600115GO_REF:0000107EnsemblGO_REF:0000107
Acta1Ratmesenchyme migration involved_inISSUniProtKB:P080231600115GO_REF:0000024AgBaseGO_REF:0000024
Acta1Ratpositive regulation of gene expression involved_inISSUniProtKB:P080231600115GO_REF:0000024AgBaseGO_REF:0000024
Acta1Ratregulation of blood pressure acts_upstream_of_or_withinIEAUniProtKB:P62737 and ensembl:ENSMUSP000000482181600115GO_REF:0000107EnsemblGO_REF:0000107
Acta1Ratresponse to mechanical stimulus  IEP 1580391 RGD 
Acta1Ratresponse to steroid hormone  IEP 1598718 RGD 
Acta1Ratresponse to virus involved_inIEAUniProtKB:P62736 and ensembl:ENSP000002247841600115GO_REF:0000107EnsemblGO_REF:0000107
Acta1Ratskeletal muscle fiber adaptation  IEP 1598721 RGD 
Acta1Ratskeletal muscle fiber development involved_inISSUniProtKB:P681341600115GO_REF:0000024UniProtGO_REF:0000024
Acta1Ratskeletal muscle fiber development involved_inISOActa1 (Mus musculus)1624291 PMID:2731651RGDPMID:2731651
Acta1Ratskeletal muscle thin filament assembly involved_inISSUniProtKB:P681331600115GO_REF:0000024UniProtGO_REF:0000024
Acta1Ratskeletal muscle thin filament assembly involved_inIBAPANTHER:PTN000233075 and UniProtKB:P681331600115GO_REF:0000033GO_CentralGO_REF:0000033
Acta1Ratskeletal muscle thin filament assembly involved_inISOACTA1 (Homo sapiens)1624291 PMID:11333380RGDPMID:11333380
Acta1Ratvascular associated smooth muscle contraction acts_upstream_of_or_withinIEAUniProtKB:P62737 and ensembl:ENSMUSP000000482181600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Acta1Ratactin cytoskeleton located_inISOACTA1 (Homo sapiens)1624291 PMID:15198992RGDPMID:15198992
Acta1Ratactin cytoskeleton is_active_inIBACGD:CAL0000191211 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Acta1Ratactin cytoskeleton located_inIEAUniProtKB:P62737 and ensembl:ENSMUSP000000482181600115GO_REF:0000107EnsemblGO_REF:0000107
Acta1Ratactin filament located_inISSUniProtKB:P681331600115GO_REF:0000024UniProtGO_REF:0000024
Acta1Ratactin filament is_active_inIBAPANTHER:PTN000233075 and UniProtKB:P681331600115GO_REF:0000033GO_CentralGO_REF:0000033
Acta1Ratactin filament located_inISOACTA1 (Homo sapiens)1624291 PMID:12849983RGDPMID:12849983
Acta1Ratcell body located_inISSUniProtKB:P080231600115GO_REF:0000024AgBaseGO_REF:0000024
Acta1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Acta1Ratcytoplasm located_inIEAUniProtKB:P62736 and ensembl:ENSP000002247841600115GO_REF:0000107EnsemblGO_REF:0000107
Acta1Ratcytoplasm located_inISSUniProtKB:P080231600115GO_REF:0000024AgBaseGO_REF:0000024
Acta1Ratcytoplasm located_inIEAUniProtKB:P62737 and ensembl:ENSMUSP000000482181600115GO_REF:0000107EnsemblGO_REF:0000107
Acta1Ratcytoskeleton located_inIEAUniProtKB-KW:KW-02061600115GO_REF:0000043UniProtGO_REF:0000043
Acta1Ratcytoskeleton located_inIEAUniProtKB:P62737 and ensembl:ENSMUSP000000482181600115GO_REF:0000107EnsemblGO_REF:0000107
Acta1Ratcytoskeleton located_inIEAUniProtKB-SubCell:SL-00901600115GO_REF:0000044UniProtGO_REF:0000044
Acta1Ratfilopodium located_inISSUniProtKB:P080231600115GO_REF:0000024AgBaseGO_REF:0000024
Acta1Ratlamellipodium located_inISSUniProtKB:P080231600115GO_REF:0000024AgBaseGO_REF:0000024
Acta1Ratmotile cilium located_inIEAUniProtKB:P62737 and ensembl:ENSMUSP000000482181600115GO_REF:0000107EnsemblGO_REF:0000107
Acta1Ratprotein-containing complex part_ofIEAUniProtKB:P62736 and ensembl:ENSP000002247841600115GO_REF:0000107EnsemblGO_REF:0000107
Acta1Ratsarcomere located_inISOACTA1 (Homo sapiens)1624291 PMID:1423520RGDPMID:1423520
Acta1Ratsmooth muscle contractile fiber located_inIEAUniProtKB:P62737 and ensembl:ENSMUSP000000482181600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function

  
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Original Reference(s)
Acta1RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Acta1Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Acta1Ratnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Acta1Ratprotein binding enablesISOACTA1 (Homo sapiens)1624291UniProtKB:P13928 more ...RGDPMID:12849983 more ...
Acta1Ratprotein binding enablesISOActa1 (Mus musculus)1624291PR:Q9Z0G0 PMID:15975910RGDPMID:15975910
Acta1Ratprotein kinase binding enablesIEAUniProtKB:P62737 and ensembl:ENSMUSP000000482181600115GO_REF:0000107EnsemblGO_REF:0000107


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#
Reference Title
Reference Citation
1. Upregulation of adrenomedullin and its receptor components during cardiomyocyte hypertrophy induced by chronic inhibition of nitric oxide synthesis in rats. Bell D, etal., Am J Physiol Heart Circ Physiol. 2006 Feb;290(2):H904-14. Epub 2005 Jul 22.
2. [Mucosal relief of the cardia in cases of carcinoma (author's transl)] Bielecki M, etal., Pol Przegl Radiol Med Nukl 1978 Mar-Apr;42(2):91-7.
3. Prevalence of chronic skin and musculoskeletal conditions. United States-1976. Bonham GS Vital Health Stat 10 1978 Nov;(124):i-iv, 1-57.
4. Comparison of soluble guanylate cyclase stimulators and activators in models of cardiovascular disease associated with oxidative stress. Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Differential gene expression in skeletal muscle cells after membrane depolarization. Juretic N, etal., J Cell Physiol. 2006 Dec 4;.
7. Myogenic signaling by lithium in cardiomyoblasts is Akt independent but requires activation of the beta-catenin-Tcf/Lef pathway. Kashour T, etal., J Mol Cell Cardiol. 2003 Aug;35(8):937-51.
8. Blockade of cysteine-rich protein 61 attenuates renal inflammation and fibrosis after ischemic kidney injury. Lai CF, etal., Am J Physiol Renal Physiol. 2014 Sep 1;307(5):F581-92. doi: 10.1152/ajprenal.00670.2013. Epub 2014 Jun 11.
9. P38 MAPK Signaling Pathway Mediates Angiotensin II-Induced miR143/145 Gene Cluster Downregulation during Aortic Dissection Formation. Li B, etal., Ann Vasc Surg. 2017 Apr;40:262-273. doi: 10.1016/j.avsg.2016.09.016. Epub 2017 Feb 4.
10. Expression of the genes coding for the skeletal muscle and cardiac actions in the heart. Mayer Y, etal., Nucleic Acids Res 1984 Jan 25;12(2):1087-100.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. GATA-4 is a nuclear mediator of mechanical stretch-activated hypertrophic program. Pikkarainen S, etal., J Biol Chem. 2003 Jun 27;278(26):23807-16. Epub 2003 Apr 17.
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
19. A proteomic assessment of muscle contractile alterations during unloading and reloading. Seo Y, etal., J Biochem (Tokyo). 2006 Jan;139(1):71-80.
20. Muscle disease caused by mutations in the skeletal muscle alpha-actin gene (ACTA1). Sparrow JC, etal., Neuromuscul Disord. 2003 Sep;13(7-8):519-31.
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PMID:1423520   PMID:2731651   PMID:6894330   PMID:11333380   PMID:12849983   PMID:15198992   PMID:15247264   PMID:15489334   PMID:16025302   PMID:16854843   PMID:17487264   PMID:19199708  
PMID:20124353   PMID:20226789   PMID:20455213   PMID:21362503   PMID:22082260   PMID:22516433   PMID:23106098   PMID:23420843   PMID:23533145   PMID:23580065   PMID:24625528   PMID:35352799  



Acta1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81968,781,168 - 68,784,194 (-)NCBIGRCr8
mRatBN7.21951,883,709 - 51,886,735 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1951,883,715 - 51,886,742 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1958,675,301 - 58,678,329 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01959,519,721 - 59,522,747 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01961,601,732 - 61,604,760 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01956,674,072 - 56,677,084 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1956,674,074 - 56,677,084 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01967,389,899 - 67,392,911 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41954,081,496 - 54,084,508 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11954,086,370 - 54,089,389 (-)NCBI
Celera1951,258,256 - 51,261,324 (-)NCBICelera
Cytogenetic Map19q12NCBI
ACTA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381229,431,245 - 229,434,094 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1229,430,365 - 229,434,104 (-)EnsemblGRCh38hg38GRCh38
GRCh371229,566,992 - 229,569,841 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361227,633,615 - 227,636,466 (-)NCBINCBI36Build 36hg18NCBI36
Build 341225,873,729 - 225,876,578NCBI
Celera1202,835,304 - 202,838,155 (-)NCBICelera
Cytogenetic Map1q42.13NCBI
HuRef1200,057,954 - 200,060,804 (-)NCBIHuRef
CHM1_11230,839,339 - 230,842,183 (-)NCBICHM1_1
T2T-CHM13v2.01228,809,946 - 228,812,800 (-)NCBIT2T-CHM13v2.0
Acta1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398124,618,497 - 124,621,514 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8124,618,508 - 124,621,490 (-)EnsemblGRCm39 Ensembl
GRCm388123,891,758 - 123,894,775 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8123,891,769 - 123,894,751 (-)EnsemblGRCm38mm10GRCm38
MGSCv378126,415,667 - 126,418,636 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368126,777,857 - 126,780,826 (-)NCBIMGSCv36mm8
Celera8128,158,816 - 128,161,785 (-)NCBICelera
Cytogenetic Map8E2NCBI
cM Map872.26NCBI
Acta1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554928,644,146 - 8,647,523 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554928,644,696 - 8,647,412 (+)NCBIChiLan1.0ChiLan1.0
ACTA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2119,778,035 - 19,780,912 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1119,970,319 - 19,973,196 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01204,975,646 - 204,978,523 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11210,007,622 - 210,010,459 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1210,007,622 - 210,010,469 (-)Ensemblpanpan1.1panPan2
ACTA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.149,811,726 - 9,814,533 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl49,811,801 - 9,814,530 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha49,802,887 - 9,805,701 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.049,842,369 - 9,845,196 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.149,846,012 - 9,848,831 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.049,960,597 - 9,963,412 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0410,212,935 - 10,215,761 (+)NCBIUU_Cfam_GSD_1.0
Acta1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934444,071,243 - 44,074,156 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648420,236,320 - 20,239,430 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648420,236,320 - 20,239,385 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACTA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1460,412,812 - 60,415,674 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11460,412,651 - 60,415,687 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21465,236,192 - 65,239,197 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACTA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12566,700,448 - 66,703,325 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2566,700,369 - 66,714,891 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605568,553,718 - 68,559,732 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acta1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477519,650,822 - 19,654,730 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477519,650,923 - 19,653,707 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Acta1
27 total Variants

Predicted Target Of
Summary Value
Count of predictions:173
Count of miRNA genes:127
Interacting mature miRNAs:138
Transcripts:ENSRNOT00000024084
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 10 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194997648153225766Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat

1 to 10 of 10 rows
PMC109669P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21211,665,199 - 11,666,019 (+)MAPPERmRatBN7.2
Rnor_6.01213,717,931 - 13,718,750NCBIRnor6.0
Rnor_5.01215,747,944 - 15,748,763UniSTSRnor5.0
RGSC_v3.41212,049,158 - 12,049,977UniSTSRGSC3.4
Celera1213,454,531 - 13,455,350UniSTS
Cytogenetic Map12p11UniSTS
Cytogenetic Map19q12UniSTS
PMC156330P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1951,258,498 - 51,259,502UniSTS
Celera1213,454,501 - 13,455,354UniSTS
Cytogenetic Map12p11UniSTS
Cytogenetic Map18p12UniSTS
Cytogenetic Map19q12UniSTS
Cytogenetic Map10q32.3UniSTS
PMC201106P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12p11UniSTS
Cytogenetic Map10q32.3UniSTS
Cytogenetic Map19q12UniSTS
Cytogenetic Map18p12UniSTS
AA959943  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21951,883,726 - 51,883,919 (+)MAPPERmRatBN7.2
Rnor_6.01956,674,086 - 56,674,278NCBIRnor6.0
Rnor_5.01967,389,913 - 67,390,105UniSTSRnor5.0
RGSC_v3.41954,081,510 - 54,081,702UniSTSRGSC3.4
Celera1951,258,270 - 51,258,462UniSTS
Cytogenetic Map19q12UniSTS
AI704778  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21951,883,725 - 51,883,943 (+)MAPPERmRatBN7.2
Rnor_6.01956,674,085 - 56,674,302NCBIRnor6.0
Rnor_5.01967,389,912 - 67,390,129UniSTSRnor5.0
RGSC_v3.41954,081,509 - 54,081,726UniSTSRGSC3.4
Celera1951,258,269 - 51,258,486UniSTS
RH 3.4 Map19733.8UniSTS
Cytogenetic Map19q12UniSTS
PMC133768P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21211,665,205 - 11,665,364 (+)MAPPERmRatBN7.2
Rnor_6.01213,717,937 - 13,718,095NCBIRnor6.0
Rnor_5.01215,747,950 - 15,748,108UniSTSRnor5.0
RGSC_v3.41212,049,164 - 12,049,322UniSTSRGSC3.4
Celera1213,454,537 - 13,454,695UniSTS
Cytogenetic Map12p11UniSTS
Cytogenetic Map19q12UniSTS
PMC151529P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21951,884,919 - 51,885,405 (+)MAPPERmRatBN7.2
Rnor_6.01956,675,279 - 56,675,764NCBIRnor6.0
Rnor_5.01967,391,106 - 67,391,591UniSTSRnor5.0
RGSC_v3.41954,082,703 - 54,083,188UniSTSRGSC3.4
Celera1951,259,519 - 51,260,004UniSTS
Cytogenetic Map19q12UniSTS
PMC156124P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12p11UniSTS
Cytogenetic Map10q32.3UniSTS
Cytogenetic Map19q12UniSTS
Cytogenetic Map18p12UniSTS
PMC133998P8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21211,664,403 - 11,665,406 (+)MAPPERmRatBN7.2
mRatBN7.21951,884,568 - 51,885,392 (+)MAPPERmRatBN7.2
Rnor_6.01956,674,928 - 56,675,751NCBIRnor6.0
Rnor_6.01213,717,135 - 13,718,137NCBIRnor6.0
Rnor_5.01967,390,755 - 67,391,578UniSTSRnor5.0
Rnor_5.01215,747,148 - 15,748,150UniSTSRnor5.0
RGSC_v3.41954,082,352 - 54,083,175UniSTSRGSC3.4
RGSC_v3.41212,048,362 - 12,049,364UniSTSRGSC3.4
Celera1213,453,735 - 13,454,737UniSTS
Celera1951,259,168 - 51,259,991UniSTS
Cytogenetic Map12p11UniSTS
Cytogenetic Map19q12UniSTS
LOC345651  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21211,664,470 - 11,665,066 (+)MAPPERmRatBN7.2
Rnor_6.01213,717,202 - 13,717,797NCBIRnor6.0
Rnor_5.01215,747,215 - 15,747,810UniSTSRnor5.0
RGSC_v3.41212,048,429 - 12,049,024UniSTSRGSC3.4
Celera1213,453,802 - 13,454,397UniSTS
Cytogenetic Map12p11UniSTS
Cytogenetic Map19q12UniSTS
Cytogenetic Map3q35UniSTS
PMC209527P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81216,777,911 - 16,778,877 (+)Marker Load Pipeline
mRatBN7.21211,664,359 - 11,665,325 (+)MAPPERmRatBN7.2
Rnor_6.01213,717,091 - 13,718,056NCBIRnor6.0
Rnor_5.01215,747,104 - 15,748,069UniSTSRnor5.0
RGSC_v3.41212,048,318 - 12,049,283UniSTSRGSC3.4
Celera1213,453,691 - 13,454,656UniSTS
Cytogenetic Map12p11UniSTS
Cytogenetic Map19q12UniSTS
PMC87052P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81216,778,931 - 16,779,578 (+)Marker Load Pipeline
mRatBN7.21211,665,379 - 11,666,026 (+)MAPPERmRatBN7.2
Rnor_6.01213,718,111 - 13,718,757NCBIRnor6.0
Rnor_5.01215,748,124 - 15,748,770UniSTSRnor5.0
RGSC_v3.41212,049,338 - 12,049,984UniSTSRGSC3.4
Celera1213,454,711 - 13,455,357UniSTS
Cytogenetic Map12p11UniSTS
Cytogenetic Map19q12UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 88 87 56 25 56 6 215 97 93 45 60 31


1 to 30 of 465 rows
RefSeq Transcripts NM_019212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC133405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 465 rows

Ensembl Acc Id: ENSRNOT00000024084   ⟹   ENSRNOP00000024084
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1951,883,715 - 51,886,742 (-)Ensembl
Rnor_6.0 Ensembl1956,674,074 - 56,677,084 (-)Ensembl
RefSeq Acc Id: NM_019212   ⟹   NP_062085
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81968,781,168 - 68,784,194 (-)NCBI
mRatBN7.21951,883,709 - 51,886,735 (-)NCBI
Rnor_6.01956,674,072 - 56,677,084 (-)NCBI
Rnor_5.01967,389,899 - 67,392,911 (-)NCBI
RGSC_v3.41954,081,496 - 54,084,508 (-)RGD
Celera1951,258,256 - 51,261,324 (-)RGD
Sequence:
1 to 9 of 9 rows
Protein RefSeqs NP_062085 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH61974 (Get FASTA)   NCBI Sequence Viewer  
  CAA24529 (Get FASTA)   NCBI Sequence Viewer  
  CAA24534 (Get FASTA)   NCBI Sequence Viewer  
  EDL96714 (Get FASTA)   NCBI Sequence Viewer  
  EDL96715 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024084
  ENSRNOP00000024084.3
GenBank Protein P68136 (Get FASTA)   NCBI Sequence Viewer  
1 to 9 of 9 rows
RefSeq Acc Id: NP_062085   ⟸   NM_019212
- UniProtKB: P68136 (UniProtKB/Swiss-Prot),   A0A0G2K4M6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024084   ⟸   ENSRNOT00000024084

Name Modeler Protein Id AA Range Protein Structure
AF-P68136-F1-model_v2 AlphaFold P68136 1-377 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13701230
Promoter ID:EPDNEW_R11754
Type:multiple initiation site
Name:Acta1_1
Description:actin, alpha 1, skeletal muscle
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01956,677,093 - 56,677,153EPDNEW


1 to 31 of 31 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-5263 BioCyc
Ensembl Genes ENSRNOG00000017786 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024084 ENTREZGENE
  ENSRNOT00000024084.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.420.40 UniProtKB/Swiss-Prot
  Actin, Chain A, domain 4 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5623909 IMAGE-MGC_LOAD
InterPro Actin UniProtKB/Swiss-Prot
  Actin/actin-like_CS UniProtKB/Swiss-Prot
  Actin_CS UniProtKB/Swiss-Prot
  ATPase_NBD UniProtKB/Swiss-Prot
KEGG Report rno:29437 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72490 IMAGE-MGC_LOAD
NCBI Gene 29437 ENTREZGENE
PANTHER PTHR11937 UniProtKB/Swiss-Prot
Pfam Actin UniProtKB/Swiss-Prot
PhenoGen Acta1 PhenoGen
PRINTS ACTIN UniProtKB/Swiss-Prot
PROSITE ACTINS_1 UniProtKB/Swiss-Prot
  ACTINS_2 UniProtKB/Swiss-Prot
  ACTINS_ACT_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017786 RatGTEx
  ENSRNOG00000058039 RatGTEx
SMART ACTIN UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53067 UniProtKB/Swiss-Prot
TIGR TC228378
UniProt A0A0G2K4M6 ENTREZGENE, UniProtKB/TrEMBL
  A6KIZ2_RAT UniProtKB/TrEMBL
  ACTS_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P02568 UniProtKB/Swiss-Prot
  P99020 UniProtKB/Swiss-Prot
1 to 31 of 31 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Acta1  actin, alpha 1, skeletal muscle    actin alpha 1  Name updated 1299863 APPROVED
2002-06-10 Acta1  actin alpha 1      Name updated 70584 APPROVED

Note Type Note Reference
gene_expression expressed in skeletal muscle 69736
gene_expression expressed in newborn cardiac muscle 69737
gene_homology gene displays a highly conserved location of intron boundaries to specific amino acid sequences from echinoderms to vertebrates 69736
gene_product member of the actin family 69736