Elk1 (ETS transcription factor ELK1) - Rat Genome Database

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Gene: Elk1 (ETS transcription factor ELK1) Rattus norvegicus
Analyze
Symbol: Elk1
Name: ETS transcription factor ELK1
RGD ID: 1598663
Description: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and chromatin binding activity. Involved in several processes, including cellular response to gamma radiation; cellular response to testosterone stimulus; and hippocampal neuron apoptotic process. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in several cellular components, including axon terminus; mitochondrial membrane; and neuronal cell body. Biomarker of anxiety disorder and transient cerebral ischemia. Orthologous to human ELK1 (ETS transcription factor ELK1); PARTICIPATES IN adenosine signaling pathway; hypoxia inducible factor pathway; platelet-derived growth factor signaling pathway; INTERACTS WITH (R)-noradrenaline; (S)-amphetamine; (S)-nicotine.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: ELK1, ETS transcription factor; ELK1, member of ETS oncogene family; ETS domain-containing protein Elk-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X3,692,367 - 3,709,252 (+)NCBIGRCr8
mRatBN7.2X1,138,826 - 1,155,713 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX1,139,756 - 1,155,713 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX1,167,915 - 1,183,790 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X4,643,607 - 4,659,482 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X964,852 - 980,733 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X1,287,875 - 1,304,822 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX1,297,099 - 1,304,822 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X2,102,893 - 2,119,843 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X12,597,863 - 12,604,248 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX1,708,719 - 1,724,604 (+)NCBICelera
Cytogenetic MapXq11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Elk1RatAlzheimer's disease  ISOELK1 (Homo sapiens)7488914 RGD 
Elk1Ratanxiety disorder amelioratesIEP 401938616associated with alcohol use disorderRGD 
Elk1RatBrain Injuries  IDA 7488910 RGD 
Elk1RatFetal Growth Retardation  ISOELK1 (Homo sapiens)7488901mRNA:decreased expression:placentaRGD 
Elk1RatHuntington's disease  ISOELK1 (Homo sapiens)7488914 RGD 
Elk1RatLewy body dementia  ISOELK1 (Homo sapiens)7488914 RGD 
Elk1Ratschizophrenia  ISOELK1 (Homo sapiens)10047412protein:increased expression:cerebellar vermisRGD 
Elk1Rattransient cerebral ischemia treatmentIEP 7488902 RGD 
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
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Original Reference(s)
Elk1Ratautistic disorder  ISOELK1 (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311
Elk1Ratcongenital disorder of glycosylation type IIm  ISOELK1 (Homo sapiens)8554872ClinVar Annotator: match by term: DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY 22ClinVarPMID:28492532
Elk1Ratimmune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome  ISOELK1 (Homo sapiens)8554872ClinVar Annotator: match by term: Insulin-dependent diabetes mellitus secretory diarrhea syndromeClinVarPMID:11137992 more ...
Elk1Ratneurodegeneration with brain iron accumulation 5  ISOELK1 (Homo sapiens)8554872ClinVar Annotator: match by term: Beta-propeller protein-associated neurodegenerationClinVarPMID:28492532
Elk1Ratsyndromic X-linked intellectual disability Lubs type  ISOELK1 (Homo sapiens)8554872ClinVar Annotator: match by term: Syndromic X-linked intellectual disability Lubs typeClinVarPMID:25741868
Elk1RatX-linked epilepsy with variable learning disabilities and behavior disorders  ISOELK1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:28492532
Elk1RatX-linked severe congenital neutropenia  ISOELK1 (Homo sapiens)8554872ClinVar Annotator: match by term: X-linked severe congenital neutropeniaClinVarPMID:10698340 more ...

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Original Reference(s)
Elk1Rat(+)-catechin multiple interactionsISOELK1 (Homo sapiens)6480464[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of ELK1 mRNACTDPMID:24763279
Elk1Rat(-)-anisomycin increases phosphorylationISOELK1 (Homo sapiens)6480464Anisomycin results in increased phosphorylation of ELK1 proteinCTDPMID:12660819
Elk1Rat(-)-anisomycin multiple interactionsISOELK1 (Homo sapiens)64804642-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Anisomycin results in increased phosphorylation of ELK1 protein] and pyrazolanthrone inhibits the reaction [Anisomycin results in increased phosphorylation of ELK1 protein]CTDPMID:12660819
Elk1Rat(-)-epigallocatechin 3-gallate multiple interactionsISOELK1 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of ELK1 mRNACTDPMID:22079256
Elk1Rat(R)-noradrenaline multiple interactionsEXP 6480464[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of ELK1 protein more ...CTDPMID:11880281
Elk1Rat(S)-amphetamine multiple interactionsEXP 64804646-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Dextroamphetamine results in increased phosphorylation of ELK1 protein] and N-phenyl-7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxamide inhibits the reaction [Dextroamphetamine results in increased phosphorylation of ELK1 protein]CTDPMID:12377393
Elk1Rat(S)-amphetamine increases phosphorylationEXP 6480464Dextroamphetamine results in increased phosphorylation of ELK1 proteinCTDPMID:12377393
Elk1Rat(S)-nicotine increases phosphorylationEXP 6480464Nicotine results in increased phosphorylation of ELK1 proteinCTDPMID:29486207
Elk1Rat(S)-nicotine increases phosphorylationISOELK1 (Homo sapiens)6480464Nicotine results in increased phosphorylation of ELK1 proteinCTDPMID:29486207
Elk1Rat(S)-nicotine multiple interactionsISOELK1 (Homo sapiens)6480464Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of ELK1 protein]CTDPMID:29486207
Elk1Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases activityISOELK1 (Homo sapiens)6480464o and p'-DDT results in increased activity of ELK1 proteinCTDPMID:18791200
Elk1Rat1,2-dichloroethane decreases expressionISOElk1 (Mus musculus)6480464ethylene dichloride results in decreased expression of ELK1 mRNACTDPMID:28960355
Elk1Rat17alpha-ethynylestradiol multiple interactionsISOElk1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ELK1 mRNACTDPMID:17942748
Elk1Rat17beta-estradiol multiple interactionsISOELK1 (Homo sapiens)6480464Estradiol results in increased phosphorylation of and results in increased activity of ELK1 protein and GPER1 protein affects the reaction [Estradiol results in increased phosphorylation of ELK1 protein]CTDPMID:16024245 and PMID:22453024
Elk1Rat17beta-estradiol increases phosphorylationISOELK1 (Homo sapiens)6480464Estradiol results in increased phosphorylation of ELK1 proteinCTDPMID:22453024
Elk1Rat17beta-estradiol increases expressionISOELK1 (Homo sapiens)6480464Estradiol results in increased expression of ELK1 mRNACTDPMID:23094148
Elk1Rat17beta-hydroxy-5alpha-androstan-3-one increases expressionISOELK1 (Homo sapiens)6480464Dihydrotestosterone results in increased expression of ELK1 mRNACTDPMID:38122923
Elk1Rat17beta-hydroxy-5alpha-androstan-3-one multiple interactionsISOELK1 (Homo sapiens)6480464apalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of ELK1 mRNA]CTDPMID:38122923
Elk1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOElk1 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of ELK1 mRNACTDPMID:19684285 and PMID:24058054
Elk1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of ELK1 mRNACTDPMID:33387578

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Biological Process
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Original Reference(s)
Elk1Ratcell differentiation involved_inIBAFB:FBgn0000097 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Elk1Ratcellular response to gamma radiation  IDA 7488908 RGD 
Elk1Ratcellular response to lipid  IDA 7488907 RGD 
Elk1Ratcellular response to testosterone stimulus  IEP 7488909 RGD 
Elk1Ratgene expression acts_upstream_of_or_withinISOElk1 (Mus musculus)1624291 PMID:31877385RGDPMID:31877385
Elk1Ratgene expression acts_upstream_of_or_withinIEAUniProtKB:P41969 and ensembl:ENSMUSP000000095501600115GO_REF:0000107EnsemblGO_REF:0000107
Elk1Rathippocampal neuron apoptotic process  IMP 7488911 RGD 
Elk1Ratliver development acts_upstream_of_or_withinISOElk1 (Mus musculus)1624291 PMID:31877385RGDPMID:31877385
Elk1Ratliver development acts_upstream_of_or_withinIEAUniProtKB:P41969 and ensembl:ENSMUSP000000095501600115GO_REF:0000107EnsemblGO_REF:0000107
Elk1Ratlung development acts_upstream_of_or_withinISOElk1 (Mus musculus)1624291 PMID:31877385RGDPMID:31877385
Elk1Ratlung development acts_upstream_of_or_withinIEAUniProtKB:P41969 and ensembl:ENSMUSP000000095501600115GO_REF:0000107EnsemblGO_REF:0000107
Elk1Ratpositive regulation of DNA-templated transcription involved_inISOELK1 (Homo sapiens)1624291 PMID:17296730 and PMID:31146003RGDPMID:17296730 and PMID:31146003
Elk1Ratpositive regulation of DNA-templated transcription acts_upstream_of_or_withinIEAUniProtKB:P19419 and ensembl:ENSP000003661821600115GO_REF:0000107EnsemblGO_REF:0000107
Elk1Ratpositive regulation of DNA-templated transcription acts_upstream_of_or_withinISOElk1 (Mus musculus)1624291 PMID:15896720RGDPMID:15896720
Elk1Ratpositive regulation of DNA-templated transcription acts_upstream_of_or_withinIEAUniProtKB:P41969 and ensembl:ENSMUSP000000095501600115GO_REF:0000107EnsemblGO_REF:0000107
Elk1Ratpositive regulation of DNA-templated transcription acts_upstream_of_or_withinISOELK1 (Homo sapiens)1624291 PMID:15790681RGDPMID:15790681
Elk1Ratpositive regulation of transcription by RNA polymerase II acts_upstream_of_or_withinIDA 8553977PMID:19029245MGI 
Elk1Ratpositive regulation of transcription by RNA polymerase II involved_inIEAUniProtKB:P19419 and ensembl:ENSP000003661821600115GO_REF:0000107EnsemblGO_REF:0000107
Elk1Ratpositive regulation of transcription by RNA polymerase II involved_inISOELK1 (Homo sapiens)1624291 PMID:12750007 more ...RGDPMID:12750007 more ...
Elk1Ratregulation of DNA-templated transcription acts_upstream_of_or_withinIEAUniProtKB:P41969 and ensembl:ENSMUSP000000095501600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Original Reference(s)
Elk1Rataxon terminus  IDA 7488913 RGD 
Elk1Ratdendrite  IDA 7488911 RGD 
Elk1Ratmitochondrial membrane  IDA 7488911ex vivo electron microscopy MMO:0000110RGD 
Elk1Ratneuronal cell body  IDA 7488911 RGD 
Elk1Ratnucleoplasm located_inIEAUniProtKB:P19419 and ensembl:ENSP000003661821600115GO_REF:0000107EnsemblGO_REF:0000107
Elk1Ratnucleoplasm located_inISOELK1 (Homo sapiens) and UniProtKB:P19419-11624291 RGDGO_REF:0000052
Elk1Ratnucleus located_inISOELK1 (Homo sapiens)1624291 PMID:20018936RGDPMID:20018936
Elk1Ratnucleus located_inIEAUniProtKB:P19419 and ensembl:ENSP000003661821600115GO_REF:0000107EnsemblGO_REF:0000107
Elk1Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Elk1Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Elk1Ratnucleus is_active_inIBAFB:FBgn0000097 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
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Molecular Function
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Original Reference(s)
Elk1Ratchromatin binding  IDA 7488907 RGD 
Elk1RatDNA binding enablesIEAUniProtKB-KW:KW-02381600115GO_REF:0000043UniProtGO_REF:0000043
Elk1RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesISOELK1 (Homo sapiens)1624291 PMID:12750007 and PMID:31146003RGDPMID:12750007 and PMID:31146003
Elk1RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesIEAUniProtKB:P19419 and ensembl:ENSP000003661821600115GO_REF:0000107EnsemblGO_REF:0000107
Elk1RatDNA-binding transcription factor activity enablesISOELK1 (Homo sapiens)1624291 PMID:14970218RGDPMID:14970218
Elk1RatDNA-binding transcription factor activity enablesIEAInterPro:IPR000418 and InterPro:IPR0463281600115GO_REF:0000002InterProGO_REF:0000002
Elk1RatDNA-binding transcription factor activity enablesISOElk1 (Mus musculus)1624291 PMID:12473665RGDPMID:12473665
Elk1RatDNA-binding transcription factor activity enablesIEAUniProtKB:P41969 and ensembl:ENSMUSP000000095501600115GO_REF:0000107EnsemblGO_REF:0000107
Elk1RatDNA-binding transcription factor activity enablesIEAUniProtKB:P19419 and ensembl:ENSP000003661821600115GO_REF:0000107EnsemblGO_REF:0000107
Elk1RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesISOELK1 (Homo sapiens)1624291 PMID:10799319RGDPMID:10799319
Elk1RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIEAUniProtKB:P19419 and ensembl:ENSP000003661821600115GO_REF:0000107EnsemblGO_REF:0000107
Elk1RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesISSUniProtKB:P194191600115GO_REF:0000024UniProtGO_REF:0000024
Elk1RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIBAFB:FBgn0000097 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Elk1Ratdouble-stranded DNA binding  IDA 628487 RGD 
Elk1Ratmediator complex binding enablesIEAUniProtKB:P41969 and ensembl:ENSMUSP000000095501600115GO_REF:0000107EnsemblGO_REF:0000107
Elk1Ratmediator complex binding enablesISOElk1 (Mus musculus)1624291UniProtKB:Q6PGF3 more ...RGDPMID:7738173
Elk1Ratprotein binding enablesISOELK1 (Homo sapiens) and UniProtKB:P19419-11624291UniProtKB:P63165 and PMID:19684601RGDPMID:19684601
Elk1Ratprotein binding enablesISOElk1 (Mus musculus)1624291UniProtKB:P30275 more ...RGDPMID:16549787 and PMID:22042868
Elk1Ratprotein binding enablesISOELK1 (Homo sapiens)1624291UniProtKB:O00358 more ...RGDPMID:16291755 more ...
Elk1RatRNA polymerase II cis-regulatory region sequence-specific DNA binding  IDA 628487 RGD 
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Imported Annotations - SMPDB

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Original Reference(s)
Elk1Ratadenosine signaling pathway  ISOELK1 (Homo sapiens)10402751 SMPDBSMP:00321
Elk1Ratadenosine signaling pathway  ISOELK1 (Homo sapiens)10402751 SMPDBSMP:00320

Imported Annotations - KEGG (archival)

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Original Reference(s)
Elk1Ratendometrial cancer pathway   IEA 6907045 KEGGrno:05213
Elk1Ratepidermal growth factor/neuregulin signaling pathway   IEA 6907045 KEGGrno:04012
Elk1Ratgonadotropin-releasing hormone signaling pathway  IEA 6907045 KEGGrno:04912
Elk1Ratinsulin signaling pathway   IEA 6907045 KEGGrno:04910
Elk1RatLeishmaniasis pathway  IEA 6907045 KEGGrno:05140
Elk1Ratmitogen activated protein kinase signaling pathway   IEA 6907045 KEGGrno:04010
Elk1Ratprion disease pathway  IEA 6907045 KEGGrno:05020

Imported Annotations - PID (archival)


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#
Reference Title
Reference Citation
1. Elk-1 associates with the mitochondrial permeability transition pore complex in neurons. Barrett LE, etal., Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5155-60. Epub 2006 Mar 20.
2. Functional components of basic fibroblast growth factor signaling that inhibit lung elastin gene expression. Carreras I, etal., Am J Physiol Lung Cell Mol Physiol 2001 Oct;281(4):L766-75.
3. Expression of phospho-Elk-1 in rat gut after the whole body gamma irradiation. Driak D, etal., Physiol Res. 2008;57(5):753-9. Epub 2007 Oct 11.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. MEK1/2 inhibition attenuates vascular ETA and ETB receptor alterations after cerebral ischaemia. Henriksson M, etal., Exp Brain Res. 2007 Apr;178(4):470-6. Epub 2006 Nov 8.
6. Changes in trkB-ERK1/2-CREB/Elk-1 pathways in hippocampal mossy fiber organization after traumatic brain injury. Hu B, etal., J Cereb Blood Flow Metab. 2004 Aug;24(8):934-43.
7. Rapid phosphorylation of Elk-1 transcription factor and activation of MAP kinase signal transduction pathways in response to visual stimulation. Kaminska B, etal., Mol Cell Neurosci. 1999 Jun;13(6):405-14.
8. Increased levels of transcription factors Elk-1, cyclic adenosine monophosphate response element-binding protein, and activating transcription factor 2 in the cerebellar vermis of schizophrenic patients. Kyosseva SV, etal., Arch Gen Psychiatry. 2000 Jul;57(7):685-91.
9. Effector immediate-early gene arc in the amygdala plays a critical role in alcoholism. Pandey SC, etal., J Neurosci. 2008 Mar 5;28(10):2589-600. doi: 10.1523/JNEUROSCI.4752-07.2008.
10. JNK- and Rac1-dependent induction of immediate early gene pip92 suppresses neuronal differentiation. Park JB, etal., J Neurochem. 2007 Jan;100(2):555-66. Epub 2006 Nov 29.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. Downstream targets of homeobox gene HLX show altered expression in human idiopathic fetal growth restriction. Rajaraman G, etal., Am J Pathol. 2010 Jan;176(1):278-87. doi: 10.2353/ajpath.2010.090187. Epub 2009 Dec 11.
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. In vivo expression and regulation of Elk-1, a target of the extracellular-regulated kinase signaling pathway, in the adult rat brain. Sgambato V, etal., J Neurosci. 1998 Jan 1;18(1):214-26.
18. A neurotoxic phosphoform of Elk-1 associates with inclusions from multiple neurodegenerative diseases. Sharma A, etal., PLoS One. 2010 Feb 2;5(2):e9002. doi: 10.1371/journal.pone.0009002.
19. The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation. Van Kanegan MJ and Strack S, Mol Cell Biol. 2009 Feb;29(3):662-74. doi: 10.1128/MCB.01242-08. Epub 2008 Nov 24.
20. Androgen inhibition of MAP kinase pathway and Elk-1 activation in proliferating osteoblasts. Wiren KM, etal., J Mol Endocrinol. 2004 Feb;32(1):209-26.
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PMID:8889548   PMID:11050086   PMID:12023815   PMID:12220646   PMID:12391846   PMID:12473665   PMID:12716432   PMID:12750007   PMID:14970218   PMID:15790681   PMID:15896720   PMID:16260603  
PMID:16987998   PMID:17244536   PMID:17296730   PMID:17301675   PMID:17334413   PMID:17505916   PMID:19013529   PMID:19389804   PMID:20018936   PMID:21171386   PMID:21362474   PMID:21677150  
PMID:21678415   PMID:21777515   PMID:21808001   PMID:22065586   PMID:22354998   PMID:22454534   PMID:23516302   PMID:24075908   PMID:26612202   PMID:30053446   PMID:38649840  



Elk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X3,692,367 - 3,709,252 (+)NCBIGRCr8
mRatBN7.2X1,138,826 - 1,155,713 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX1,139,756 - 1,155,713 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX1,167,915 - 1,183,790 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X4,643,607 - 4,659,482 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X964,852 - 980,733 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X1,287,875 - 1,304,822 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX1,297,099 - 1,304,822 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X2,102,893 - 2,119,843 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X12,597,863 - 12,604,248 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX1,708,719 - 1,724,604 (+)NCBICelera
Cytogenetic MapXq11NCBI
ELK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X47,635,520 - 47,650,604 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX47,635,520 - 47,650,604 (-)EnsemblGRCh38hg38GRCh38
GRCh37X47,494,919 - 47,510,003 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X47,379,864 - 47,394,964 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X47,251,173 - 47,266,274NCBI
CeleraX51,690,183 - 51,705,266 (-)NCBICelera
Cytogenetic MapXp11.23NCBI
HuRefX45,207,767 - 45,222,756 (-)NCBIHuRef
CHM1_1X47,526,023 - 47,541,139 (-)NCBICHM1_1
T2T-CHM13v2.0X47,045,421 - 47,060,507 (-)NCBIT2T-CHM13v2.0
Elk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X20,799,634 - 20,816,847 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX20,799,634 - 20,816,847 (-)EnsemblGRCm39 Ensembl
GRCm38X20,933,395 - 20,950,608 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX20,933,395 - 20,950,608 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X20,510,521 - 20,527,726 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X20,091,886 - 20,107,552 (-)NCBIMGSCv36mm8
CeleraX19,067,257 - 19,084,739 (-)NCBICelera
Cytogenetic MapXA1.3NCBI
cM MapX16.45NCBI
Elk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955516430,775 - 444,871 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955516431,081 - 444,871 (+)NCBIChiLan1.0ChiLan1.0
ELK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X49,261,994 - 49,277,081 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X49,265,366 - 49,280,456 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X40,071,433 - 40,086,518 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X47,967,492 - 47,982,590 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX47,967,492 - 47,982,579 (-)Ensemblpanpan1.1panPan2
ELK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X41,256,205 - 41,270,656 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX41,257,482 - 41,270,776 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX15,630,809 - 15,645,355 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X41,390,004 - 41,404,542 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX41,390,011 - 41,404,542 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X41,377,550 - 41,392,091 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X41,365,833 - 41,380,367 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X41,458,515 - 41,473,055 (-)NCBIUU_Cfam_GSD_1.0
Elk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X33,561,981 - 33,577,464 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650213,402,728 - 13,418,214 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650213,402,726 - 13,418,214 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ELK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX42,157,988 - 42,174,951 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X42,157,980 - 42,174,964 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X47,303,918 - 47,320,907 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103231899
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X44,812,681 - 44,827,657 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666868398 - 6,908 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Elk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624978194,992 - 208,103 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624978194,985 - 208,105 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Elk1
21 total Variants

Predicted Target Of
Summary Value
Count of predictions:618
Count of miRNA genes:284
Interacting mature miRNAs:373
Transcripts:ENSRNOT00000013522
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat

RH142956  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X1,141,957 - 1,142,089 (+)MAPPERmRatBN7.2
Rnor_6.0X1,291,069 - 1,291,200NCBIRnor6.0
Rnor_5.0X2,106,090 - 2,106,221UniSTSRnor5.0
RGSC_v3.4X12,612,753 - 12,612,884UniSTSRGSC3.4
CeleraX1,710,853 - 1,710,984UniSTS
Cytogenetic MapXq12UniSTS
RH140607  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X1,141,654 - 1,141,860 (+)MAPPERmRatBN7.2
Rnor_6.0X1,290,766 - 1,290,971NCBIRnor6.0
Rnor_5.0X2,105,787 - 2,105,992UniSTSRnor5.0
RGSC_v3.4X12,612,982 - 12,613,187UniSTSRGSC3.4
CeleraX1,710,550 - 1,710,755UniSTS
Cytogenetic MapXq12UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000013522   ⟹   ENSRNOP00000013522
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX1,139,756 - 1,155,713 (+)Ensembl
Rnor_6.0 EnsemblX1,297,099 - 1,304,822 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109793   ⟹   ENSRNOP00000085214
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX1,139,878 - 1,155,713 (+)Ensembl
RefSeq Acc Id: NM_001108059   ⟹   NP_001101529
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X3,693,365 - 3,709,252 (+)NCBI
mRatBN7.2X1,139,824 - 1,155,713 (+)NCBI
Rnor_6.0X1,288,935 - 1,304,822 (+)NCBI
Rnor_5.0X2,102,893 - 2,119,843 (+)NCBI
RGSC_v3.4X12,597,863 - 12,604,248 (-)RGD
CeleraX1,708,719 - 1,724,604 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006256614   ⟹   XP_006256676
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X3,692,367 - 3,709,252 (+)NCBI
mRatBN7.2X1,138,826 - 1,155,713 (+)NCBI
Rnor_6.0X1,287,875 - 1,304,822 (+)NCBI
Rnor_5.0X2,102,893 - 2,119,843 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063280007   ⟹   XP_063136077
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X3,692,367 - 3,709,252 (+)NCBI
Protein RefSeqs NP_001101529 (Get FASTA)   NCBI Sequence Viewer  
  XP_006256676 (Get FASTA)   NCBI Sequence Viewer  
  XP_063136077 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A4GTP4 (Get FASTA)   NCBI Sequence Viewer  
  ABO27185 (Get FASTA)   NCBI Sequence Viewer  
  EDL97728 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013522
  ENSRNOP00000013522.3
RefSeq Acc Id: NP_001101529   ⟸   NM_001108059
- UniProtKB: A4GTP4 (UniProtKB/TrEMBL),   A0A8I6A3K1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256676   ⟸   XM_006256614
- Peptide Label: isoform X1
- UniProtKB: A4GTP4 (UniProtKB/TrEMBL),   A0A8I6A3K1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013522   ⟸   ENSRNOT00000013522
Ensembl Acc Id: ENSRNOP00000085214   ⟸   ENSRNOT00000109793
RefSeq Acc Id: XP_063136077   ⟸   XM_063280007
- Peptide Label: isoform X2

Name Modeler Protein Id AA Range Protein Structure
AF-A4GTP4-F1-model_v2 AlphaFold A4GTP4 1-427 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 24 of 24 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-3203 BioCyc
Ensembl Genes ENSRNOG00000010171 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013522 ENTREZGENE
  ENSRNOT00000013522.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot
InterPro Ets_dom UniProtKB/Swiss-Prot
  ETS_fam UniProtKB/Swiss-Prot
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot
  WH_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report rno:314436 UniProtKB/Swiss-Prot
NCBI Gene 314436 ENTREZGENE
PANTHER ETS DOMAIN-CONTAINING PROTEIN ELK-1 UniProtKB/Swiss-Prot
  PTHR11849 UniProtKB/Swiss-Prot
Pfam Ets UniProtKB/Swiss-Prot
PhenoGen Elk1 PhenoGen
PRINTS ETSDOMAIN UniProtKB/Swiss-Prot
PROSITE ETS_DOMAIN_1 UniProtKB/Swiss-Prot
  ETS_DOMAIN_2 UniProtKB/Swiss-Prot
  ETS_DOMAIN_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010171 RatGTEx
SMART ETS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot
UniProt A0A8I6A3K1 ENTREZGENE, UniProtKB/TrEMBL
  A4GTP4 ENTREZGENE, UniProtKB/Swiss-Prot
1 to 24 of 24 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-10 Elk1  ETS transcription factor ELK1  Elk1  ELK1, ETS transcription factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-01 Elk1  ELK1, ETS transcription factor  Elk1  ELK1, member of ETS oncogene family  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-12-10 Elk1  ELK1, member of ETS oncogene family      Symbol and Name status set to provisional 70820 PROVISIONAL