Symbol:
Rrm2
Name:
ribonucleotide reductase regulatory subunit M2
RGD ID:
1598310
Description:
Predicted to enable ferric iron binding activity; protein homodimerization activity; and ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in positive regulation of cell population proliferation and pyrimidine nucleobase metabolic process. Located in nuclear envelope. Used to study endometrial adenocarcinoma. Biomarker of urinary bladder cancer. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human RRM2 (ribonucleotide reductase regulatory subunit M2); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Previously known as:
MGC116120; ribonucleoside-diphosphate reductase subunit M2; Ribonucleotide reductase 2; ribonucleotide reductase M2; ribonucleotide reductase M2 (mapped); ribonucleotide reductase M2 polypeptide; ribonucleotide reductase small chain; ribonucleotide reductase small subunit; Rrm2_mapped
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 6 47,044,755 - 47,075,370 (+) NCBI GRCr8 mRatBN7.2 6 41,339,858 - 41,346,774 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 6 41,340,557 - 41,346,773 (+) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 6 41,660,659 - 41,666,878 (+) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 6 41,975,466 - 41,981,683 (+) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 6 41,408,612 - 41,414,829 (+) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 6 43,884,627 - 43,890,818 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 6 43,884,678 - 43,889,515 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 6 60,756,160 - 60,762,351 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 6 42,350,541 - 42,356,748 (+) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 Celera 6 40,627,438 - 40,633,641 (+) NCBI Celera Cytogenetic Map 6 q16 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Only show annotations with direct experimental evidence (0 objects hidden)
Rrm2 Rat (-)-demecolcine decreases expression ISO RRM2 (Homo sapiens) 6480464 Demecolcine results in decreased expression of RRM2 mRNA CTD PMID:23649840 Rrm2 Rat 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane decreases expression ISO RRM2 (Homo sapiens) 6480464 o and p'-DDT results in decreased expression of RRM2 mRNA CTD PMID:18204070 Rrm2 Rat 1,1-dichloroethene increases expression ISO Rrm2 (Mus musculus) 6480464 vinylidene chloride results in increased expression of RRM2 mRNA CTD PMID:26682919 Rrm2 Rat 1-chloro-2,4-dinitrobenzene increases expression ISO Rrm2 (Mus musculus) 6480464 Dinitrochlorobenzene results in increased expression of RRM2 mRNA CTD PMID:21404309 Rrm2 Rat 1-naphthyl isothiocyanate increases expression EXP 6480464 1-Naphthylisothiocyanate results in increased expression of RRM2 mRNA CTD PMID:30723492 Rrm2 Rat 17alpha-ethynylestradiol affects expression EXP 6480464 Ethinyl Estradiol affects the expression of RRM2 mRNA CTD PMID:17351261 Rrm2 Rat 17beta-estradiol increases expression ISO RRM2 (Homo sapiens) 6480464 Estradiol results in increased expression of RRM2 mRNA CTD PMID:16474171 more ... Rrm2 Rat 17beta-estradiol decreases expression ISO Rrm2 (Mus musculus) 6480464 Estradiol results in decreased expression of RRM2 mRNA CTD PMID:39298647 Rrm2 Rat 17beta-estradiol multiple interactions EXP 6480464 [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of RRM2 mRNA CTD PMID:32741896 Rrm2 Rat 17beta-estradiol affects expression EXP 6480464 Estradiol affects the expression of RRM2 mRNA CTD PMID:32145629 Rrm2 Rat 17beta-estradiol multiple interactions ISO RRM2 (Homo sapiens) 6480464 [Progesterone co-treated with Estradiol] results in decreased expression of RRM2 mRNA CTD PMID:17404688 Rrm2 Rat 17beta-estradiol affects expression ISO Rrm2 (Mus musculus) 6480464 Estradiol affects the expression of RRM2 mRNA CTD PMID:15598610 Rrm2 Rat 17beta-estradiol decreases expression ISO RRM2 (Homo sapiens) 6480464 Estradiol results in decreased expression of RRM2 mRNA CTD PMID:20106945 Rrm2 Rat 17beta-estradiol 3-benzoate multiple interactions EXP 6480464 [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of RRM2 mRNA CTD PMID:32741896 Rrm2 Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Rrm2 (Mus musculus) 6480464 2 more ... CTD PMID:25510870 and PMID:32352317 Rrm2 Rat 2,2',4,4'-Tetrabromodiphenyl ether decreases expression ISO RRM2 (Homo sapiens) 6480464 2 more ... CTD PMID:19095052 Rrm2 Rat 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO Rrm2 (Mus musculus) 6480464 [2 more ... CTD PMID:25510870 Rrm2 Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Rrm2 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of RRM2 mRNA CTD PMID:19770486 and PMID:25270620 Rrm2 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of RRM2 mRNA CTD PMID:34747641 Rrm2 Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of RRM2 mRNA CTD PMID:32109520 Rrm2 Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Rrm2 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of RRM2 mRNA CTD PMID:21570461 and PMID:26377647 Rrm2 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Rrm2 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased expression of RRM2 mRNA CTD PMID:15667827 and PMID:19465110 Rrm2 Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RRM2 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin affects the expression of RRM2 mRNA CTD PMID:22574217 Rrm2 Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RRM2 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in decreased expression of RRM2 mRNA CTD PMID:21802500 Rrm2 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RRM2 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in increased expression of RRM2 mRNA CTD PMID:20106945 Rrm2 Rat 2,4-diaminotoluene increases expression ISO Rrm2 (Mus musculus) 6480464 2 and 4-diaminotoluene results in increased expression of RRM2 mRNA CTD PMID:20713471 Rrm2 Rat 2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expression ISO Rrm2 (Mus musculus) 6480464 2 more ... CTD PMID:38648751 Rrm2 Rat 2-butoxyethanol increases expression ISO Rrm2 (Mus musculus) 6480464 n-butoxyethanol results in increased expression of RRM2 mRNA CTD PMID:19812364 Rrm2 Rat 2-palmitoylglycerol increases expression ISO RRM2 (Homo sapiens) 6480464 2-palmitoylglycerol results in increased expression of RRM2 mRNA CTD PMID:37199045 Rrm2 Rat 3-chloropropane-1,2-diol increases expression EXP 6480464 alpha-Chlorohydrin results in increased expression of RRM2 mRNA CTD PMID:28522335 Rrm2 Rat 3-methylcholanthrene increases expression ISO Rrm2 (Mus musculus) 6480464 Methylcholanthrene results in increased expression of RRM2 mRNA CTD PMID:20713471 Rrm2 Rat 4,4'-diaminodiphenylmethane increases expression ISO Rrm2 (Mus musculus) 6480464 4 and 4'-diaminodiphenylmethane results in increased expression of RRM2 mRNA CTD PMID:18648102 Rrm2 Rat 4,4'-sulfonyldiphenol decreases expression ISO Rrm2 (Mus musculus) 6480464 bisphenol S results in decreased expression of RRM2 mRNA CTD PMID:39298647 Rrm2 Rat 4-(ethoxymethylene)-2-phenyloxazol-5-one increases expression ISO Rrm2 (Mus musculus) 6480464 Oxazolone results in increased expression of RRM2 mRNA CTD PMID:21404309 Rrm2 Rat 4-hydroxyphenyl retinamide increases expression ISO Rrm2 (Mus musculus) 6480464 Fenretinide results in increased expression of RRM2 mRNA CTD PMID:28973697 Rrm2 Rat 4-nitroquinoline N-oxide decreases expression ISO Rrm2 (Mus musculus) 6480464 4-Nitroquinoline-1-oxide results in decreased expression of RRM2 mRNA CTD PMID:22561872 Rrm2 Rat 5-azacytidine multiple interactions ISO RRM2 (Homo sapiens) 6480464 [Azacitidine co-treated with Thalidomide] affects the expression of RRM2 mRNA CTD PMID:18720364 Rrm2 Rat 5-fluorouracil affects expression ISO RRM2 (Homo sapiens) 6480464 Fluorouracil affects the expression of RRM2 mRNA CTD PMID:15205334 and PMID:16584549 Rrm2 Rat 5-fluorouracil increases expression ISO RRM2 (Homo sapiens) 6480464 Fluorouracil results in increased expression of RRM2 mRNA CTD PMID:16709241 Rrm2 Rat 5-fluorouracil affects response to substance ISO RRM2 (Homo sapiens) 6480464 RRM2 protein affects the susceptibility to Fluorouracil CTD PMID:15548681 Rrm2 Rat 5-fluorouracil multiple interactions ISO RRM2 (Homo sapiens) 6480464 RRM2 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 Rrm2 Rat 5-fluorouracil decreases expression ISO RRM2 (Homo sapiens) 6480464 Fluorouracil results in decreased expression of RRM2 mRNA CTD PMID:16557594 and PMID:17039268 Rrm2 Rat 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of RRM2 mRNA CTD PMID:24780913 and PMID:30047161 Rrm2 Rat 7,12-dimethyltetraphene increases expression ISO Rrm2 (Mus musculus) 6480464 9 more ... CTD PMID:32553695 Rrm2 Rat 8-Br-cAMP decreases expression ISO RRM2 (Homo sapiens) 6480464 8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of RRM2 mRNA CTD PMID:22079614 Rrm2 Rat acetamide increases expression EXP 6480464 acetamide results in increased expression of RRM2 mRNA CTD PMID:31881176 Rrm2 Rat acrylamide increases expression EXP 6480464 Acrylamide results in increased expression of RRM2 mRNA CTD PMID:28959563 Rrm2 Rat acrylamide decreases expression ISO RRM2 (Homo sapiens) 6480464 Acrylamide results in decreased expression of RRM2 mRNA CTD PMID:32763439 Rrm2 Rat aflatoxin B1 decreases expression ISO Rrm2 (Mus musculus) 6480464 Aflatoxin B1 results in decreased expression of RRM2 mRNA CTD PMID:19770486 Rrm2 Rat aflatoxin B1 affects expression ISO RRM2 (Homo sapiens) 6480464 Aflatoxin B1 affects the expression of RRM2 protein CTD PMID:20106945 Rrm2 Rat all-trans-retinoic acid decreases expression ISO RRM2 (Homo sapiens) 6480464 Tretinoin results in decreased expression of RRM2 mRNA CTD PMID:15498508 and PMID:33167477 Rrm2 Rat amitrole decreases expression EXP 6480464 Amitrole results in decreased expression of RRM2 mRNA CTD PMID:38685447 Rrm2 Rat amitrole increases expression EXP 6480464 Amitrole results in increased expression of RRM2 mRNA CTD PMID:30047161 Rrm2 Rat amphetamine increases expression EXP 6480464 Amphetamine results in increased expression of RRM2 mRNA CTD PMID:30779732 Rrm2 Rat antimycin A decreases expression ISO Rrm2 (Mus musculus) 6480464 Antimycin A results in decreased expression of RRM2 mRNA CTD PMID:19304788 Rrm2 Rat antimycin A increases expression ISO RRM2 (Homo sapiens) 6480464 Antimycin A results in increased expression of RRM2 mRNA CTD PMID:33512557 Rrm2 Rat aristolochic acid A decreases expression ISO RRM2 (Homo sapiens) 6480464 aristolochic acid I results in decreased expression of RRM2 mRNA CTD PMID:33212167 Rrm2 Rat aristolochic acid A increases expression ISO RRM2 (Homo sapiens) 6480464 aristolochic acid I results in increased expression of RRM2 mRNA and aristolochic acid I results in increased expression of RRM2 protein CTD PMID:33212167 Rrm2 Rat arsenous acid decreases expression ISO RRM2 (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of RRM2 mRNA and Arsenic Trioxide results in decreased expression of RRM2 protein CTD PMID:25419056 and PMID:26705709 Rrm2 Rat azathioprine decreases expression ISO RRM2 (Homo sapiens) 6480464 Azathioprine results in decreased expression of RRM2 mRNA CTD PMID:22623647 Rrm2 Rat benzo[a]pyrene decreases expression ISO RRM2 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased expression of RRM2 mRNA CTD PMID:20064835 more ... Rrm2 Rat benzo[a]pyrene affects methylation ISO RRM2 (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of RRM2 3' UTR and Benzo(a)pyrene affects the methylation of RRM2 promoter CTD PMID:27901495 Rrm2 Rat benzo[a]pyrene multiple interactions ISO Rrm2 (Mus musculus) 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RRM2 mRNA CTD PMID:27858113 Rrm2 Rat benzo[a]pyrene decreases expression ISO Rrm2 (Mus musculus) 6480464 Benzo(a)pyrene results in decreased expression of RRM2 mRNA CTD PMID:17942131 and PMID:19770486 Rrm2 Rat benzo[a]pyrene diol epoxide I decreases expression ISO RRM2 (Homo sapiens) 6480464 7 more ... CTD PMID:20382639 Rrm2 Rat benzo[b]fluoranthene increases expression ISO Rrm2 (Mus musculus) 6480464 benzo(b)fluoranthene results in increased expression of RRM2 mRNA CTD PMID:26377693 Rrm2 Rat benzo[b]fluoranthene multiple interactions ISO Rrm2 (Mus musculus) 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RRM2 mRNA CTD PMID:27858113 Rrm2 Rat beta-lapachone decreases expression ISO RRM2 (Homo sapiens) 6480464 beta-lapachone results in decreased expression of RRM2 mRNA CTD PMID:38218311 Rrm2 Rat bicalutamide decreases expression ISO RRM2 (Homo sapiens) 6480464 bicalutamide results in decreased expression of RRM2 mRNA CTD PMID:15638997 Rrm2 Rat biphenyl-4-amine multiple interactions ISO RRM2 (Homo sapiens) 6480464 TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of RRM2 mRNA] CTD PMID:32905825 Rrm2 Rat biphenyl-4-amine decreases expression ISO RRM2 (Homo sapiens) 6480464 4-biphenylamine results in decreased expression of RRM2 mRNA CTD PMID:32905825 Rrm2 Rat bis(2-chloroethyl) sulfide decreases expression ISO RRM2 (Homo sapiens) 6480464 Mustard Gas results in decreased expression of RRM2 mRNA CTD PMID:25102026 Rrm2 Rat bisphenol A increases expression ISO RRM2 (Homo sapiens) 6480464 bisphenol A results in increased expression of RRM2 mRNA CTD PMID:16474171 and PMID:31715268 Rrm2 Rat bisphenol A multiple interactions ISO RRM2 (Homo sapiens) 6480464 [bisphenol A co-treated with Fulvestrant] results in increased methylation of RRM2 gene CTD PMID:31601247 Rrm2 Rat bisphenol A affects expression ISO RRM2 (Homo sapiens) 6480464 bisphenol A affects the expression of RRM2 mRNA CTD PMID:30903817 Rrm2 Rat bisphenol A decreases expression ISO RRM2 (Homo sapiens) 6480464 bisphenol A results in decreased expression of RRM2 mRNA and bisphenol A results in decreased expression of RRM2 protein CTD PMID:29275510 and PMID:37567409 Rrm2 Rat bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of RRM2 mRNA CTD PMID:30816183 and PMID:32145629 Rrm2 Rat bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of RRM2 gene CTD PMID:28505145 Rrm2 Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of RRM2 mRNA CTD PMID:25181051 and PMID:32528016 Rrm2 Rat bisphenol F increases expression ISO Rrm2 (Mus musculus) 6480464 bisphenol F results in increased expression of RRM2 mRNA CTD PMID:38685157 Rrm2 Rat buspirone decreases expression EXP 6480464 Buspirone results in decreased expression of RRM2 mRNA CTD PMID:24136188 Rrm2 Rat butanal decreases expression ISO RRM2 (Homo sapiens) 6480464 butyraldehyde results in decreased expression of RRM2 mRNA CTD PMID:26079696 Rrm2 Rat Butylbenzyl phthalate decreases expression ISO Rrm2 (Mus musculus) 6480464 butylbenzyl phthalate results in decreased expression of RRM2 mRNA CTD PMID:32308655 Rrm2 Rat cadmium atom decreases expression ISO RRM2 (Homo sapiens) 6480464 Cadmium results in decreased expression of RRM2 mRNA CTD PMID:21120746 Rrm2 Rat cadmium atom multiple interactions ISO Rrm2 (Mus musculus) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of RRM2 mRNA CTD PMID:37325564 Rrm2 Rat cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of RRM2 mRNA CTD PMID:25993096 Rrm2 Rat cadmium dichloride multiple interactions ISO Rrm2 (Mus musculus) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of RRM2 mRNA CTD PMID:37325564 Rrm2 Rat cadmium dichloride increases expression ISO RRM2 (Homo sapiens) 6480464 Cadmium Chloride results in increased expression of RRM2 mRNA CTD PMID:38382870 Rrm2 Rat cadmium dichloride decreases expression ISO RRM2 (Homo sapiens) 6480464 Cadmium Chloride results in decreased expression of RRM2 mRNA CTD PMID:26314618 Rrm2 Rat caffeine multiple interactions ISO Rrm2 (Mus musculus) 6480464 Caffeine inhibits the reaction [Camptothecin results in increased expression of RRM2 mRNA] and Caffeine inhibits the reaction [Camptothecin results in increased expression of RRM2 protein] CTD PMID:22403396 Rrm2 Rat calcitriol decreases expression ISO RRM2 (Homo sapiens) 6480464 Calcitriol results in decreased expression of RRM2 mRNA CTD PMID:21592394 Rrm2 Rat calcitriol multiple interactions ISO RRM2 (Homo sapiens) 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of RRM2 mRNA CTD PMID:21592394 Rrm2 Rat camptothecin increases expression ISO Rrm2 (Mus musculus) 6480464 Camptothecin results in increased expression of RRM2 mRNA and Camptothecin results in increased expression of RRM2 protein CTD PMID:22403396 Rrm2 Rat camptothecin multiple interactions ISO Rrm2 (Mus musculus) 6480464 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Camptothecin results in increased expression of RRM2 protein] more ... CTD PMID:22403396 Rrm2 Rat cannabidiol decreases expression ISO RRM2 (Homo sapiens) 6480464 Cannabidiol results in decreased expression of RRM2 mRNA CTD PMID:36519830 Rrm2 Rat carbamazepine affects expression ISO RRM2 (Homo sapiens) 6480464 Carbamazepine affects the expression of RRM2 mRNA CTD PMID:25979313 Rrm2 Rat carbon nanotube affects expression ISO Rrm2 (Mus musculus) 6480464 Nanotubes and Carbon affects the expression of RRM2 mRNA CTD PMID:25554681 Rrm2 Rat carbon nanotube decreases expression ISO Rrm2 (Mus musculus) 6480464 Nanotubes and Carbon results in decreased expression of RRM2 mRNA CTD PMID:25620056 Rrm2 Rat carbon nanotube increases expression ISO Rrm2 (Mus musculus) 6480464 Nanotubes and Carbon analog results in increased expression of RRM2 mRNA CTD PMID:25554681 Rrm2 Rat cefaloridine decreases expression EXP 6480464 Cephaloridine results in decreased expression of RRM2 mRNA CTD PMID:18500788 Rrm2 Rat celastrol decreases expression ISO RRM2 (Homo sapiens) 6480464 celastrol results in decreased expression of RRM2 mRNA CTD PMID:17010675 Rrm2 Rat choline multiple interactions ISO Rrm2 (Mus musculus) 6480464 [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of RRM2 mRNA CTD PMID:33549593 Rrm2 Rat chromium(6+) affects expression ISO Rrm2 (Mus musculus) 6480464 chromium hexavalent ion affects the expression of RRM2 mRNA CTD PMID:28472532 Rrm2 Rat chromium(6+) multiple interactions ISO RRM2 (Homo sapiens) 6480464 [zinc chromate results in increased abundance of chromium hexavalent ion] which results in decreased expression of RRM2 mRNA CTD PMID:38479592 Rrm2 Rat chrysene multiple interactions ISO Rrm2 (Mus musculus) 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RRM2 mRNA CTD PMID:27858113 Rrm2 Rat ciclopirox decreases activity ISO Rrm2 (Mus musculus) 6480464 ciclopirox results in decreased activity of RRM2 protein CTD PMID:19589922 Rrm2 Rat ciguatoxin CTX1B affects expression ISO Rrm2 (Mus musculus) 6480464 Ciguatoxins affects the expression of RRM2 mRNA CTD PMID:18353800 Rrm2 Rat cisplatin increases expression ISO RRM2 (Homo sapiens) 6480464 Cisplatin results in increased expression of RRM2 mRNA CTD PMID:27594783 and PMID:33545341 Rrm2 Rat cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of RRM2 mRNA CTD PMID:22023808 Rrm2 Rat cisplatin multiple interactions ISO RRM2 (Homo sapiens) 6480464 BRCA1 mutant form promotes the reaction [RRM2 mutant form promotes the reaction [TP53 mutant form promotes the reaction [Cisplatin results in increased activity of and results in increased phosphorylation of CHEK1 protein]]] more ... CTD PMID:21875941 Rrm2 Rat cobalt atom multiple interactions ISO RRM2 (Homo sapiens) 6480464 [tungsten carbide co-treated with Cobalt] results in increased expression of RRM2 mRNA CTD PMID:23052192 Rrm2 Rat cobalt dichloride decreases expression ISO RRM2 (Homo sapiens) 6480464 cobaltous chloride results in decreased expression of RRM2 mRNA CTD PMID:19320972 and PMID:19376846 Rrm2 Rat copper atom multiple interactions ISO RRM2 (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which results in increased expression of RRM2 mRNA and [NSC 689534 binds to Copper] which results in decreased expression of RRM2 mRNA CTD PMID:20971185 and PMID:30911355 Rrm2 Rat copper atom increases expression EXP 6480464 Copper results in increased expression of RRM2 mRNA CTD PMID:22465980 Rrm2 Rat copper(0) multiple interactions ISO RRM2 (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which results in increased expression of RRM2 mRNA and [NSC 689534 binds to Copper] which results in decreased expression of RRM2 mRNA CTD PMID:20971185 and PMID:30911355 Rrm2 Rat copper(0) increases expression EXP 6480464 Copper results in increased expression of RRM2 mRNA CTD PMID:22465980 Rrm2 Rat copper(II) chloride increases expression ISO RRM2 (Homo sapiens) 6480464 cupric chloride results in increased expression of RRM2 mRNA CTD PMID:38568856 Rrm2 Rat corosolic acid decreases expression ISO RRM2 (Homo sapiens) 6480464 corosolic acid results in decreased expression of RRM2 mRNA and corosolic acid results in decreased expression of RRM2 protein CTD PMID:37939859 Rrm2 Rat coumarin affects phosphorylation ISO RRM2 (Homo sapiens) 6480464 coumarin affects the phosphorylation of RRM2 protein CTD PMID:35688186 Rrm2 Rat coumestrol increases expression ISO RRM2 (Homo sapiens) 6480464 Coumestrol results in increased expression of RRM2 mRNA CTD PMID:19167446 Rrm2 Rat coumestrol multiple interactions ISO RRM2 (Homo sapiens) 6480464 [Coumestrol co-treated with 2 more ... CTD PMID:19167446 Rrm2 Rat crocidolite asbestos decreases expression ISO RRM2 (Homo sapiens) 6480464 Asbestos and Crocidolite results in decreased expression of RRM2 mRNA CTD PMID:29523930 Rrm2 Rat CU-O LINKAGE decreases expression ISO RRM2 (Homo sapiens) 6480464 cupric oxide results in decreased expression of RRM2 mRNA CTD PMID:22077320 Rrm2 Rat Cuprizon increases expression EXP 6480464 Cuprizone results in increased expression of RRM2 mRNA CTD PMID:26577399 Rrm2 Rat cyanocob(III)alamin multiple interactions ISO Rrm2 (Mus musculus) 6480464 [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of RRM2 mRNA CTD PMID:33549593 Rrm2 Rat cycloheximide multiple interactions ISO Rrm2 (Mus musculus) 6480464 Cycloheximide inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA] CTD PMID:22403396 Rrm2 Rat cyclophosphamide multiple interactions ISO RRM2 (Homo sapiens) 6480464 RRM2 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 Rrm2 Rat cyclosporin A decreases expression ISO Rrm2 (Mus musculus) 6480464 Cyclosporine results in decreased expression of RRM2 mRNA CTD PMID:17942131 and PMID:19770486 Rrm2 Rat cyclosporin A affects expression ISO RRM2 (Homo sapiens) 6480464 Cyclosporine affects the expression of RRM2 mRNA CTD PMID:25562108 Rrm2 Rat cyclosporin A decreases expression ISO RRM2 (Homo sapiens) 6480464 Cyclosporine results in decreased expression of RRM2 mRNA CTD PMID:19159671 more ... Rrm2 Rat cytarabine increases expression ISO RRM2 (Homo sapiens) 6480464 Cytarabine results in increased expression of RRM2 mRNA CTD PMID:19194470 Rrm2 Rat DDE increases expression ISO RRM2 (Homo sapiens) 6480464 Dichlorodiphenyl Dichloroethylene results in increased expression of RRM2 mRNA CTD PMID:38568856 Rrm2 Rat decabromodiphenyl ether decreases expression EXP 6480464 decabromobiphenyl ether results in decreased expression of RRM2 mRNA CTD PMID:23640034 Rrm2 Rat decabromodiphenyl ether increases expression EXP 6480464 decabromobiphenyl ether results in increased expression of RRM2 mRNA CTD PMID:23914054 Rrm2 Rat dexamethasone increases expression ISO Rrm2 (Mus musculus) 6480464 Dexamethasone results in increased expression of RRM2 mRNA CTD PMID:22733784 Rrm2 Rat diallyl trisulfide decreases expression ISO RRM2 (Homo sapiens) 6480464 diallyl trisulfide results in decreased expression of RRM2 mRNA CTD PMID:34995734 Rrm2 Rat diarsenic trioxide decreases expression ISO RRM2 (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of RRM2 mRNA and Arsenic Trioxide results in decreased expression of RRM2 protein CTD PMID:25419056 and PMID:26705709 Rrm2 Rat dibenz[a,h]anthracene increases expression ISO Rrm2 (Mus musculus) 6480464 1 more ... CTD PMID:26377693 Rrm2 Rat Dibutyl phosphate affects expression ISO RRM2 (Homo sapiens) 6480464 di-n-butylphosphoric acid affects the expression of RRM2 mRNA CTD PMID:37042841 Rrm2 Rat dibutyl phthalate decreases expression ISO Rrm2 (Mus musculus) 6480464 Dibutyl Phthalate results in decreased expression of RRM2 mRNA CTD PMID:21266533 Rrm2 Rat dibutyl phthalate increases expression ISO RRM2 (Homo sapiens) 6480464 Dibutyl Phthalate results in increased expression of RRM2 mRNA CTD PMID:36828243 Rrm2 Rat dibutyl phthalate multiple interactions ISO RRM2 (Homo sapiens) 6480464 N-methyl-delta-3 more ... CTD PMID:36828243 Rrm2 Rat dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of RRM2 mRNA CTD PMID:21266533 Rrm2 Rat diethyl maleate increases expression EXP 6480464 diethyl maleate results in increased expression of RRM2 mRNA CTD PMID:21161181 Rrm2 Rat diethyl maleate increases expression ISO RRM2 (Homo sapiens) 6480464 diethyl maleate results in increased expression of RRM2 mRNA CTD PMID:33545341 Rrm2 Rat diethylstilbestrol increases expression ISO RRM2 (Homo sapiens) 6480464 Diethylstilbestrol results in increased expression of RRM2 mRNA CTD PMID:36621641 Rrm2 Rat dimethylarsinic acid increases expression EXP 6480464 Cacodylic Acid results in increased expression of RRM2 mRNA CTD PMID:37567419 Rrm2 Rat dioxygen multiple interactions ISO Rrm2 (Mus musculus) 6480464 [Iron co-treated with Oxygen] binds to RRM2 protein CTD PMID:16829694 Rrm2 Rat dioxygen decreases expression ISO RRM2 (Homo sapiens) 6480464 Oxygen deficiency results in decreased expression of RRM2 mRNA CTD PMID:26516004 Rrm2 Rat doxorubicin affects expression ISO RRM2 (Homo sapiens) 6480464 Doxorubicin affects the expression of RRM2 mRNA CTD PMID:15205334 Rrm2 Rat doxorubicin decreases expression ISO RRM2 (Homo sapiens) 6480464 Doxorubicin results in decreased expression of RRM2 mRNA CTD PMID:29803840 and PMID:30031762 Rrm2 Rat doxorubicin multiple interactions ISO RRM2 (Homo sapiens) 6480464 RRM2 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 Rrm2 Rat Enterolactone multiple interactions ISO RRM2 (Homo sapiens) 6480464 [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of RRM2 mRNA CTD PMID:19167446 Rrm2 Rat epoxiconazole decreases expression ISO Rrm2 (Mus musculus) 6480464 epoxiconazole results in decreased expression of RRM2 mRNA CTD PMID:35436446 Rrm2 Rat erythromycin estolate decreases expression EXP 6480464 Erythromycin Estolate results in decreased expression of RRM2 mRNA CTD PMID:24412560 Rrm2 Rat erythromycin estolate increases expression EXP 6480464 Erythromycin Estolate results in increased expression of RRM2 mRNA CTD PMID:24412560 Rrm2 Rat ethanol decreases expression ISO RRM2 (Homo sapiens) 6480464 Ethanol results in decreased expression of RRM2 mRNA CTD PMID:23378141 Rrm2 Rat finasteride increases expression EXP 6480464 Finasteride results in increased expression of RRM2 mRNA CTD PMID:24136188 Rrm2 Rat fipronil decreases expression EXP 6480464 fipronil results in decreased expression of RRM2 mRNA CTD PMID:34044035 Rrm2 Rat folic acid multiple interactions ISO RRM2 (Homo sapiens) 6480464 [Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of RRM2 mRNA CTD PMID:24657277 Rrm2 Rat folic acid multiple interactions ISO Rrm2 (Mus musculus) 6480464 [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of RRM2 mRNA CTD PMID:33549593 Rrm2 Rat FR900359 decreases phosphorylation ISO RRM2 (Homo sapiens) 6480464 FR900359 results in decreased phosphorylation of RRM2 protein CTD PMID:37730182 Rrm2 Rat fulvestrant multiple interactions ISO RRM2 (Homo sapiens) 6480464 [bisphenol A co-treated with Fulvestrant] results in increased methylation of RRM2 gene CTD PMID:31601247 Rrm2 Rat furan increases expression EXP 6480464 furan results in increased expression of RRM2 mRNA CTD PMID:25539665 Rrm2 Rat gamma-tocopherol increases expression ISO Rrm2 (Mus musculus) 6480464 Tocopherols results in increased expression of RRM2 mRNA CTD PMID:17056531 Rrm2 Rat gedunin decreases expression ISO RRM2 (Homo sapiens) 6480464 gedunin results in decreased expression of RRM2 mRNA CTD PMID:17010675 Rrm2 Rat gemcitabine affects response to substance ISO RRM2 (Homo sapiens) 6480464 RRM2 protein affects the susceptibility to Gemcitabine CTD PMID:26894857 Rrm2 Rat gemcitabine multiple interactions ISO RRM2 (Homo sapiens) 6480464 [Gemcitabine results in decreased susceptibility to Gemcitabine] which results in increased expression of RRM2 protein CTD PMID:25189999 Rrm2 Rat genistein increases expression ISO RRM2 (Homo sapiens) 6480464 Genistein results in increased expression of RRM2 mRNA CTD PMID:16474171 and PMID:20884965 Rrm2 Rat genistein decreases expression ISO RRM2 (Homo sapiens) 6480464 Genistein results in decreased expression of RRM2 mRNA CTD PMID:22228119 Rrm2 Rat glycidol decreases expression EXP 6480464 glycidol results in decreased expression of RRM2 mRNA CTD PMID:24395379 Rrm2 Rat glycine betaine decreases expression EXP 6480464 Betaine results in decreased expression of RRM2 mRNA CTD PMID:26391144 Rrm2 Rat glycine betaine multiple interactions ISO Rrm2 (Mus musculus) 6480464 [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of RRM2 mRNA CTD PMID:33549593 Rrm2 Rat hydroxyurea decreases activity ISO Rrm2 (Mus musculus) 6480464 Hydroxyurea results in decreased activity of RRM2 protein CTD PMID:22403396 Rrm2 Rat indole-3-methanol multiple interactions EXP 6480464 [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of RRM2 mRNA CTD PMID:22129741 Rrm2 Rat iron atom multiple interactions ISO Rrm2 (Mus musculus) 6480464 [Iron co-treated with Oxygen] binds to RRM2 protein CTD PMID:16829694 Rrm2 Rat iron dichloride increases expression ISO RRM2 (Homo sapiens) 6480464 ferrous chloride results in increased expression of RRM2 mRNA CTD PMID:35984750 Rrm2 Rat iron(0) multiple interactions ISO Rrm2 (Mus musculus) 6480464 [Iron co-treated with Oxygen] binds to RRM2 protein CTD PMID:16829694 Rrm2 Rat ivermectin decreases expression ISO RRM2 (Homo sapiens) 6480464 Ivermectin results in decreased expression of RRM2 protein CTD PMID:32959892 Rrm2 Rat ketamine decreases expression EXP 6480464 Ketamine results in decreased expression of RRM2 mRNA CTD PMID:20080153 Rrm2 Rat ketoconazole increases expression ISO RRM2 (Homo sapiens) 6480464 Ketoconazole results in increased expression of RRM2 mRNA CTD PMID:36621641 Rrm2 Rat L-methionine multiple interactions ISO Rrm2 (Mus musculus) 6480464 [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of RRM2 mRNA CTD PMID:33549593 Rrm2 Rat leflunomide decreases expression ISO RRM2 (Homo sapiens) 6480464 leflunomide results in decreased expression of RRM2 mRNA CTD PMID:28988120 Rrm2 Rat leflunomide decreases expression EXP 6480464 leflunomide results in decreased expression of RRM2 mRNA CTD PMID:24136188 Rrm2 Rat levofloxacin decreases expression EXP 6480464 Levofloxacin results in decreased expression of RRM2 mRNA CTD PMID:24136188 Rrm2 Rat lidocaine increases expression EXP 6480464 Lidocaine results in increased expression of RRM2 mRNA CTD PMID:35283115 Rrm2 Rat lipopolysaccharide multiple interactions ISO RRM2 (Homo sapiens) 6480464 Plant Extracts affects the reaction [Lipopolysaccharides affects the expression of RRM2 mRNA] CTD PMID:28070326 Rrm2 Rat lipopolysaccharide affects expression ISO RRM2 (Homo sapiens) 6480464 Lipopolysaccharides affects the expression of RRM2 mRNA CTD PMID:28070326 Rrm2 Rat lucanthone decreases expression ISO RRM2 (Homo sapiens) 6480464 Lucanthone results in decreased expression of RRM2 mRNA CTD PMID:21148553 Rrm2 Rat LY294002 multiple interactions ISO Rrm2 (Mus musculus) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA] CTD PMID:22403396 Rrm2 Rat lycopene increases expression ISO RRM2 (Homo sapiens) 6480464 lycopene results in increased expression of RRM2 mRNA CTD PMID:16886892 Rrm2 Rat MeIQx increases expression ISO RRM2 (Homo sapiens) 6480464 2-amino-3 more ... CTD PMID:20816883 Rrm2 Rat metformin increases expression EXP 6480464 Metformin results in increased expression of RRM2 mRNA CTD PMID:31324951 Rrm2 Rat methamphetamine decreases expression ISO RRM2 (Homo sapiens) 6480464 Methamphetamine results in decreased expression of RRM2 mRNA CTD PMID:25290377 Rrm2 Rat methamphetamine decreases expression EXP 6480464 Methamphetamine results in decreased expression of RRM2 mRNA and Methamphetamine results in decreased expression of RRM2 protein CTD PMID:28341135 Rrm2 Rat methimazole increases expression EXP 6480464 Methimazole results in increased expression of RRM2 mRNA CTD PMID:30047161 Rrm2 Rat methotrexate affects expression ISO Rrm2 (Mus musculus) 6480464 Methotrexate affects the expression of RRM2 mRNA CTD PMID:18502557 Rrm2 Rat methotrexate decreases expression ISO RRM2 (Homo sapiens) 6480464 Methotrexate results in decreased expression of RRM2 mRNA CTD PMID:24657277 Rrm2 Rat methotrexate multiple interactions ISO RRM2 (Homo sapiens) 6480464 [Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of RRM2 mRNA CTD PMID:24657277 Rrm2 Rat methyl methanesulfonate increases expression ISO RRM2 (Homo sapiens) 6480464 Methyl Methanesulfonate results in increased expression of RRM2 mRNA CTD PMID:23649840 Rrm2 Rat methylseleninic acid affects expression ISO RRM2 (Homo sapiens) 6480464 methylselenic acid affects the expression of RRM2 mRNA CTD PMID:14617803 Rrm2 Rat miconazole increases expression ISO Rrm2 (Mus musculus) 6480464 Miconazole results in increased expression of RRM2 mRNA CTD PMID:27462272 Rrm2 Rat mifepristone multiple interactions ISO Rrm2 (Mus musculus) 6480464 7-hydroxystaurosporine promotes the reaction [Mifepristone inhibits the reaction [Progesterone results in increased expression of RRM2 protein]] more ... CTD PMID:22403396 Rrm2 Rat mono(2-ethylhexyl) phthalate decreases expression ISO Rrm2 (Mus musculus) 6480464 mono-(2-ethylhexyl)phthalate results in decreased expression of RRM2 mRNA CTD PMID:33162236 Rrm2 Rat N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO Rrm2 (Mus musculus) 6480464 [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of RRM2 mRNA CTD PMID:25566086 Rrm2 Rat N-methyl-4-phenylpyridinium decreases expression ISO Rrm2 (Mus musculus) 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of RRM2 mRNA CTD PMID:17475336 Rrm2 Rat N-methyl-4-phenylpyridinium decreases expression ISO RRM2 (Homo sapiens) 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of RRM2 mRNA CTD PMID:24810058 Rrm2 Rat N-methyl-N'-nitro-N-nitrosoguanidine increases expression ISO RRM2 (Homo sapiens) 6480464 Methylnitronitrosoguanidine results in increased expression of RRM2 mRNA CTD PMID:26921499 Rrm2 Rat N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions ISO RRM2 (Homo sapiens) 6480464 [[Methylnitronitrosoguanidine results in increased phosphorylation of and results in increased stability of and results in increased expression of E2F3 protein] which results in increased expression of RRM2 mRNA] inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of H2AX protein modified form] more ... CTD PMID:26921499 Rrm2 Rat N-nitrosodiethylamine multiple interactions ISO Rrm2 (Mus musculus) 6480464 [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of RRM2 mRNA CTD PMID:24535843 Rrm2 Rat N-nitrosodiethylamine multiple interactions EXP 6480464 [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of RRM2 mRNA CTD PMID:22129741 Rrm2 Rat N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of RRM2 mRNA CTD PMID:19638242 Rrm2 Rat N-nitrosodiethylamine increases expression ISO Rrm2 (Mus musculus) 6480464 Diethylnitrosamine results in increased expression of RRM2 mRNA CTD PMID:17854601 Rrm2 Rat N-Nitrosopyrrolidine decreases expression ISO RRM2 (Homo sapiens) 6480464 N-Nitrosopyrrolidine results in decreased expression of RRM2 mRNA CTD PMID:32234424 Rrm2 Rat nefazodone decreases expression EXP 6480464 nefazodone results in decreased expression of RRM2 mRNA CTD PMID:24136188 Rrm2 Rat nickel atom increases expression ISO RRM2 (Homo sapiens) 6480464 Nickel results in increased expression of RRM2 mRNA CTD PMID:25583101 Rrm2 Rat niclosamide decreases expression ISO RRM2 (Homo sapiens) 6480464 Niclosamide results in decreased expression of RRM2 mRNA CTD PMID:28284560 Rrm2 Rat nimesulide decreases expression EXP 6480464 nimesulide results in decreased expression of RRM2 mRNA CTD PMID:24136188 Rrm2 Rat oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of RRM2 mRNA CTD PMID:25729387 Rrm2 Rat oxaliplatin decreases expression EXP 6480464 oxaliplatin results in decreased expression of RRM2 mRNA CTD PMID:25729387 Rrm2 Rat ozone increases expression ISO Rrm2 (Mus musculus) 6480464 Ozone results in increased expression of RRM2 mRNA CTD PMID:19555225 Rrm2 Rat ozone multiple interactions ISO Rrm2 (Mus musculus) 6480464 [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of RRM2 mRNA more ... CTD PMID:25658374 and PMID:34911549 Rrm2 Rat ozone decreases expression ISO Rrm2 (Mus musculus) 6480464 Ozone results in decreased expression of RRM2 mRNA CTD PMID:24336422 Rrm2 Rat paclitaxel multiple interactions ISO RRM2 (Homo sapiens) 6480464 RRM2 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 Rrm2 Rat palbociclib decreases expression ISO RRM2 (Homo sapiens) 6480464 palbociclib results in decreased expression of RRM2 mRNA CTD PMID:22869556 Rrm2 Rat paracetamol decreases expression ISO Rrm2 (Mus musculus) 6480464 Acetaminophen results in decreased expression of RRM2 mRNA CTD PMID:17942131 Rrm2 Rat paracetamol decreases expression ISO RRM2 (Homo sapiens) 6480464 Acetaminophen results in decreased expression of RRM2 mRNA CTD PMID:29067470 Rrm2 Rat paracetamol increases expression ISO Rrm2 (Mus musculus) 6480464 Acetaminophen results in increased expression of RRM2 mRNA CTD PMID:24126418 Rrm2 Rat PCB138 multiple interactions ISO Rrm2 (Mus musculus) 6480464 [2 more ... CTD PMID:25510870 Rrm2 Rat perfluorohexanesulfonic acid increases expression ISO Rrm2 (Mus musculus) 6480464 perfluorohexanesulfonic acid results in increased expression of RRM2 mRNA CTD PMID:37995155 Rrm2 Rat perfluorononanoic acid decreases expression ISO RRM2 (Homo sapiens) 6480464 perfluoro-n-nonanoic acid results in decreased expression of RRM2 mRNA CTD PMID:32588087 Rrm2 Rat perfluorooctanoic acid decreases expression ISO RRM2 (Homo sapiens) 6480464 perfluorooctanoic acid results in decreased expression of RRM2 mRNA CTD PMID:23978341 and PMID:36326898 Rrm2 Rat phenformin decreases expression EXP 6480464 Phenformin results in decreased expression of RRM2 mRNA CTD PMID:31324951 Rrm2 Rat phenobarbital multiple interactions ISO Rrm2 (Mus musculus) 6480464 [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of RRM2 mRNA more ... CTD PMID:19482888 more ... Rrm2 Rat phenobarbital increases expression ISO Rrm2 (Mus musculus) 6480464 Phenobarbital results in increased expression of RRM2 mRNA CTD PMID:19482888 more ... Rrm2 Rat phenobarbital affects expression ISO RRM2 (Homo sapiens) 6480464 Phenobarbital affects the expression of RRM2 mRNA CTD PMID:19159669 Rrm2 Rat PhIP increases expression EXP 6480464 2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine results in increased expression of RRM2 mRNA CTD PMID:29877212 Rrm2 Rat phytoestrogen increases expression ISO RRM2 (Homo sapiens) 6480464 Phytoestrogens results in increased expression of RRM2 mRNA CTD PMID:18310284 Rrm2 Rat picoxystrobin increases expression ISO RRM2 (Homo sapiens) 6480464 picoxystrobin results in increased expression of RRM2 mRNA CTD PMID:33512557 Rrm2 Rat pinosylvin decreases expression ISO RRM2 (Homo sapiens) 6480464 pinosylvin results in decreased expression of RRM2 mRNA CTD PMID:23333577 Rrm2 Rat piperonyl butoxide increases expression EXP 6480464 Piperonyl Butoxide results in increased expression of RRM2 mRNA CTD PMID:22484513 Rrm2 Rat pirinixic acid increases expression ISO Rrm2 (Mus musculus) 6480464 pirinixic acid results in increased expression of RRM2 mRNA CTD PMID:18301758 more ... Rrm2 Rat piroxicam decreases expression ISO RRM2 (Homo sapiens) 6480464 Piroxicam results in decreased expression of RRM2 mRNA CTD PMID:21858171 Rrm2 Rat potassium dichromate increases expression ISO RRM2 (Homo sapiens) 6480464 Potassium Dichromate results in increased expression of RRM2 protein CTD PMID:23718831 Rrm2 Rat pregnenolone 16alpha-carbonitrile increases expression EXP 6480464 Pregnenolone Carbonitrile results in increased expression of RRM2 mRNA CTD PMID:30047161 Rrm2 Rat progesterone decreases expression ISO RRM2 (Homo sapiens) 6480464 Progesterone results in decreased expression of RRM2 mRNA CTD PMID:21795739 Rrm2 Rat progesterone multiple interactions ISO Rrm2 (Mus musculus) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA] more ... CTD PMID:22403396 Rrm2 Rat progesterone increases expression ISO RRM2 (Homo sapiens) 6480464 Progesterone results in increased expression of RRM2 mRNA CTD PMID:18070364 Rrm2 Rat progesterone increases expression ISO Rrm2 (Mus musculus) 6480464 Progesterone results in increased expression of RRM2 mRNA and Progesterone results in increased expression of RRM2 protein CTD PMID:22403396 Rrm2 Rat progesterone multiple interactions ISO RRM2 (Homo sapiens) 6480464 [Progesterone co-treated with Estradiol] results in decreased expression of RRM2 mRNA CTD PMID:17404688 Rrm2 Rat propanal decreases expression ISO RRM2 (Homo sapiens) 6480464 propionaldehyde results in decreased expression of RRM2 mRNA CTD PMID:26079696 Rrm2 Rat propiconazole increases expression ISO Rrm2 (Mus musculus) 6480464 propiconazole results in increased expression of RRM2 mRNA CTD PMID:21278054 Rrm2 Rat quercetin decreases expression ISO RRM2 (Homo sapiens) 6480464 Quercetin results in decreased expression of RRM2 mRNA CTD PMID:21632981 Rrm2 Rat resveratrol multiple interactions ISO RRM2 (Homo sapiens) 6480464 [Coumestrol co-treated with resveratrol] results in increased expression of RRM2 mRNA CTD PMID:19167446 Rrm2 Rat resveratrol decreases expression ISO RRM2 (Homo sapiens) 6480464 resveratrol results in decreased expression of RRM2 mRNA CTD PMID:15767336 Rrm2 Rat rotenone decreases expression ISO Rrm2 (Mus musculus) 6480464 Rotenone results in decreased expression of RRM2 mRNA CTD PMID:19304788 Rrm2 Rat rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of RRM2 mRNA and Rotenone results in decreased expression of RRM2 protein CTD PMID:28374803 and PMID:35544339 Rrm2 Rat rotenone increases expression EXP 6480464 Rotenone results in increased expression of RRM2 mRNA CTD PMID:19013527 Rrm2 Rat SB 431542 multiple interactions ISO RRM2 (Homo sapiens) 6480464 [LDN 193189 co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein] results in decreased expression of RRM2 protein CTD PMID:37664457 Rrm2 Rat serpentine asbestos increases expression ISO RRM2 (Homo sapiens) 6480464 Asbestos and Serpentine results in increased expression of RRM2 mRNA CTD PMID:24160326 Rrm2 Rat silicon dioxide increases expression ISO RRM2 (Homo sapiens) 6480464 Silicon Dioxide analog results in increased expression of RRM2 mRNA CTD PMID:25895662 Rrm2 Rat silicon dioxide increases expression ISO Rrm2 (Mus musculus) 6480464 Silicon Dioxide results in increased expression of RRM2 mRNA CTD PMID:29341224 Rrm2 Rat silicon dioxide increases expression EXP 6480464 Silicon Dioxide results in increased expression of RRM2 mRNA CTD PMID:22431001 Rrm2 Rat silicon dioxide decreases expression ISO RRM2 (Homo sapiens) 6480464 Silicon Dioxide analog results in decreased expression of RRM2 mRNA and Silicon Dioxide results in decreased expression of RRM2 mRNA CTD PMID:23806026 and PMID:25351596 Rrm2 Rat sodium arsenite decreases expression ISO RRM2 (Homo sapiens) 6480464 sodium arsenite results in decreased expression of RRM2 mRNA and sodium arsenite results in decreased expression of RRM2 protein CTD PMID:20371982 more ... Rrm2 Rat sodium arsenite decreases expression ISO Rrm2 (Mus musculus) 6480464 sodium arsenite results in decreased expression of RRM2 mRNA CTD PMID:37682722 Rrm2 Rat sodium arsenite affects expression ISO RRM2 (Homo sapiens) 6480464 sodium arsenite affects the expression of RRM2 mRNA CTD PMID:29301061 and PMID:34032870 Rrm2 Rat sodium arsenite increases expression ISO RRM2 (Homo sapiens) 6480464 sodium arsenite results in increased expression of RRM2 mRNA CTD PMID:28595984 Rrm2 Rat sodium dichromate increases expression ISO Rrm2 (Mus musculus) 6480464 sodium bichromate results in increased expression of RRM2 mRNA CTD PMID:22155349 Rrm2 Rat sodium dichromate affects expression EXP 6480464 sodium bichromate affects the expression of RRM2 mRNA CTD PMID:22110744 Rrm2 Rat Soman increases expression EXP 6480464 Soman results in increased expression of RRM2 mRNA CTD PMID:19281266 Rrm2 Rat sulfadimethoxine increases expression EXP 6480464 Sulfadimethoxine results in increased expression of RRM2 mRNA CTD PMID:30047161 Rrm2 Rat sulindac sulfide decreases expression ISO RRM2 (Homo sapiens) 6480464 sulindac sulfide results in decreased expression of RRM2 mRNA CTD PMID:12734198 Rrm2 Rat sunitinib decreases expression ISO RRM2 (Homo sapiens) 6480464 Sunitinib results in decreased expression of RRM2 mRNA CTD PMID:31533062 Rrm2 Rat tamibarotene affects expression ISO RRM2 (Homo sapiens) 6480464 tamibarotene affects the expression of RRM2 mRNA CTD PMID:15498508 Rrm2 Rat tebufenpyrad increases expression ISO RRM2 (Homo sapiens) 6480464 4-chloro-N-((4-(1 and 1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide results in increased expression of RRM2 mRNA CTD PMID:33512557 Rrm2 Rat testosterone decreases expression ISO RRM2 (Homo sapiens) 6480464 Testosterone results in decreased expression of RRM2 mRNA CTD PMID:21592394 Rrm2 Rat testosterone multiple interactions EXP 6480464 [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of RRM2 mRNA CTD PMID:32741896 Rrm2 Rat testosterone decreases expression ISO Rrm2 (Mus musculus) 6480464 Testosterone deficiency results in decreased expression of RRM2 mRNA CTD PMID:33848595 Rrm2 Rat testosterone multiple interactions ISO RRM2 (Homo sapiens) 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of RRM2 mRNA CTD PMID:21592394 Rrm2 Rat tetrachloromethane affects expression ISO Rrm2 (Mus musculus) 6480464 Carbon Tetrachloride affects the expression of RRM2 mRNA CTD PMID:17484886 Rrm2 Rat tetrachloromethane increases expression ISO Rrm2 (Mus musculus) 6480464 Carbon Tetrachloride results in increased expression of RRM2 mRNA CTD PMID:27339419 more ... Rrm2 Rat tetraphene multiple interactions ISO Rrm2 (Mus musculus) 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RRM2 mRNA CTD PMID:27858113 Rrm2 Rat thalidomide multiple interactions ISO RRM2 (Homo sapiens) 6480464 [Azacitidine co-treated with Thalidomide] affects the expression of RRM2 mRNA CTD PMID:18720364 Rrm2 Rat thapsigargin decreases expression ISO RRM2 (Homo sapiens) 6480464 Thapsigargin results in decreased expression of RRM2 mRNA CTD PMID:22378314 Rrm2 Rat thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of RRM2 mRNA CTD PMID:23411599 Rrm2 Rat thiram decreases expression ISO RRM2 (Homo sapiens) 6480464 Thiram results in decreased expression of RRM2 mRNA CTD PMID:38568856 Rrm2 Rat titanium dioxide increases expression ISO Rrm2 (Mus musculus) 6480464 titanium dioxide results in increased expression of RRM2 mRNA CTD PMID:23557971 Rrm2 Rat titanium dioxide decreases methylation ISO Rrm2 (Mus musculus) 6480464 titanium dioxide results in decreased methylation of RRM2 gene and titanium dioxide results in decreased methylation of RRM2 promoter CTD PMID:35295148 Rrm2 Rat titanium dioxide increases expression EXP 6480464 titanium dioxide results in increased expression of RRM2 mRNA CTD PMID:30012374 Rrm2 Rat titanium dioxide affects expression ISO Rrm2 (Mus musculus) 6480464 titanium dioxide affects the expression of RRM2 mRNA CTD PMID:17656681 Rrm2 Rat tocopherol increases expression ISO Rrm2 (Mus musculus) 6480464 Tocopherols results in increased expression of RRM2 mRNA CTD PMID:17056531 Rrm2 Rat toluene 2,4-diisocyanate increases expression ISO Rrm2 (Mus musculus) 6480464 Toluene 2 and 4-Diisocyanate results in increased expression of RRM2 mRNA CTD PMID:21404309 Rrm2 Rat topotecan decreases expression EXP 6480464 Topotecan results in decreased expression of RRM2 mRNA CTD PMID:25729387 Rrm2 Rat topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of RRM2 mRNA CTD PMID:25729387 Rrm2 Rat trans-pinosylvin decreases expression ISO RRM2 (Homo sapiens) 6480464 pinosylvin results in decreased expression of RRM2 mRNA CTD PMID:23333577 Rrm2 Rat Tributyltin oxide decreases expression ISO Rrm2 (Mus musculus) 6480464 bis(tri-n-butyltin)oxide results in decreased expression of RRM2 mRNA CTD PMID:17942131 Rrm2 Rat Tributyltin oxide decreases phosphorylation ISO Rrm2 (Mus musculus) 6480464 bis(tri-n-butyltin)oxide results in decreased phosphorylation of RRM2 protein CTD PMID:22174045 Rrm2 Rat triclosan decreases expression ISO RRM2 (Homo sapiens) 6480464 Triclosan results in decreased expression of RRM2 mRNA CTD PMID:30510588 Rrm2 Rat trimellitic anhydride increases expression ISO Rrm2 (Mus musculus) 6480464 trimellitic anhydride results in increased expression of RRM2 mRNA CTD PMID:19042947 Rrm2 Rat triptonide decreases expression ISO Rrm2 (Mus musculus) 6480464 triptonide results in decreased expression of RRM2 mRNA CTD PMID:33045310 Rrm2 Rat triticonazole increases expression EXP 6480464 triticonazole results in increased expression of RRM2 mRNA CTD PMID:36084822 Rrm2 Rat troglitazone decreases expression ISO RRM2 (Homo sapiens) 6480464 troglitazone results in decreased expression of RRM2 mRNA CTD PMID:19140230 Rrm2 Rat trovafloxacin decreases expression EXP 6480464 trovafloxacin results in decreased expression of RRM2 mRNA CTD PMID:24136188 Rrm2 Rat trovafloxacin decreases expression ISO Rrm2 (Mus musculus) 6480464 trovafloxacin results in decreased expression of RRM2 mRNA CTD PMID:35537566 Rrm2 Rat Tungsten carbide multiple interactions ISO RRM2 (Homo sapiens) 6480464 [tungsten carbide co-treated with Cobalt] results in increased expression of RRM2 mRNA CTD PMID:23052192 Rrm2 Rat tunicamycin decreases expression ISO RRM2 (Homo sapiens) 6480464 Tunicamycin results in decreased expression of RRM2 mRNA CTD PMID:22378314 Rrm2 Rat valdecoxib decreases expression EXP 6480464 valdecoxib results in decreased expression of RRM2 mRNA CTD PMID:24136188 Rrm2 Rat valproic acid decreases expression ISO Rrm2 (Mus musculus) 6480464 Valproic Acid results in decreased expression of RRM2 mRNA CTD PMID:21427059 Rrm2 Rat valproic acid affects expression ISO RRM2 (Homo sapiens) 6480464 Valproic Acid affects the expression of RRM2 mRNA CTD PMID:25979313 Rrm2 Rat valproic acid increases methylation ISO RRM2 (Homo sapiens) 6480464 Valproic Acid results in increased methylation of RRM2 gene CTD PMID:29154799 Rrm2 Rat valproic acid decreases expression ISO RRM2 (Homo sapiens) 6480464 Valproic Acid results in decreased expression of RRM2 mRNA CTD PMID:19101580 Rrm2 Rat vincaleukoblastine affects response to substance ISO RRM2 (Homo sapiens) 6480464 RRM2 protein affects the susceptibility to Vinblastine CTD PMID:16217747 Rrm2 Rat vincristine decreases expression ISO RRM2 (Homo sapiens) 6480464 Vincristine results in decreased expression of RRM2 mRNA CTD PMID:23649840 Rrm2 Rat zinc atom multiple interactions ISO Rrm2 (Mus musculus) 6480464 [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of RRM2 mRNA CTD PMID:33549593 Rrm2 Rat zinc(0) multiple interactions ISO Rrm2 (Mus musculus) 6480464 [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of RRM2 mRNA CTD PMID:33549593 Rrm2 Rat zoledronic acid decreases expression ISO RRM2 (Homo sapiens) 6480464 zoledronic acid results in decreased expression of RRM2 mRNA CTD PMID:24714768
Imported Annotations - SMPDB
Imported Annotations - KEGG (archival)
(-)-demecolcine (ISO) 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (ISO) 1,1-dichloroethene (ISO) 1-chloro-2,4-dinitrobenzene (ISO) 1-naphthyl isothiocyanate (EXP) 17alpha-ethynylestradiol (EXP) 17beta-estradiol (EXP,ISO) 17beta-estradiol 3-benzoate (EXP) 2,2',4,4',5,5'-hexachlorobiphenyl (ISO) 2,2',4,4'-Tetrabromodiphenyl ether (ISO) 2,2',5,5'-tetrachlorobiphenyl (ISO) 2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO) 2,4-diaminotoluene (ISO) 2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO) 2-butoxyethanol (ISO) 2-palmitoylglycerol (ISO) 3-chloropropane-1,2-diol (EXP) 3-methylcholanthrene (ISO) 4,4'-diaminodiphenylmethane (ISO) 4,4'-sulfonyldiphenol (ISO) 4-(ethoxymethylene)-2-phenyloxazol-5-one (ISO) 4-hydroxyphenyl retinamide (ISO) 4-nitroquinoline N-oxide (ISO) 5-azacytidine (ISO) 5-fluorouracil (ISO) 6-propyl-2-thiouracil (EXP) 7,12-dimethyltetraphene (ISO) 8-Br-cAMP (ISO) acetamide (EXP) acrylamide (EXP,ISO) aflatoxin B1 (ISO) all-trans-retinoic acid (ISO) amitrole (EXP) amphetamine (EXP) antimycin A (ISO) aristolochic acid A (ISO) arsenous acid (ISO) azathioprine (ISO) benzo[a]pyrene (ISO) benzo[a]pyrene diol epoxide I (ISO) benzo[b]fluoranthene (ISO) beta-lapachone (ISO) bicalutamide (ISO) biphenyl-4-amine (ISO) bis(2-chloroethyl) sulfide (ISO) bisphenol A (EXP,ISO) bisphenol F (ISO) buspirone (EXP) butanal (ISO) Butylbenzyl phthalate (ISO) cadmium atom (ISO) cadmium dichloride (EXP,ISO) caffeine (ISO) calcitriol (ISO) camptothecin (ISO) cannabidiol (ISO) carbamazepine (ISO) carbon nanotube (ISO) cefaloridine (EXP) celastrol (ISO) choline (ISO) chromium(6+) (ISO) chrysene (ISO) ciclopirox (ISO) ciguatoxin CTX1B (ISO) cisplatin (EXP,ISO) cobalt atom (ISO) cobalt dichloride (ISO) copper atom (EXP,ISO) copper(0) (EXP,ISO) copper(II) chloride (ISO) corosolic acid (ISO) coumarin (ISO) coumestrol (ISO) crocidolite asbestos (ISO) CU-O LINKAGE (ISO) Cuprizon (EXP) cyanocob(III)alamin (ISO) cycloheximide (ISO) cyclophosphamide (ISO) cyclosporin A (ISO) cytarabine (ISO) DDE (ISO) decabromodiphenyl ether (EXP) dexamethasone (ISO) diallyl trisulfide (ISO) diarsenic trioxide (ISO) dibenz[a,h]anthracene (ISO) Dibutyl phosphate (ISO) dibutyl phthalate (EXP,ISO) diethyl maleate (EXP,ISO) diethylstilbestrol (ISO) dimethylarsinic acid (EXP) dioxygen (ISO) doxorubicin (ISO) Enterolactone (ISO) epoxiconazole (ISO) erythromycin estolate (EXP) ethanol (ISO) finasteride (EXP) fipronil (EXP) folic acid (ISO) FR900359 (ISO) fulvestrant (ISO) furan (EXP) gamma-tocopherol (ISO) gedunin (ISO) gemcitabine (ISO) genistein (ISO) glycidol (EXP) glycine betaine (EXP,ISO) hydroxyurea (ISO) indole-3-methanol (EXP) iron atom (ISO) iron dichloride (ISO) iron(0) (ISO) ivermectin (ISO) ketamine (EXP) ketoconazole (ISO) L-methionine (ISO) leflunomide (EXP,ISO) levofloxacin (EXP) lidocaine (EXP) lipopolysaccharide (ISO) lucanthone (ISO) LY294002 (ISO) lycopene (ISO) MeIQx (ISO) metformin (EXP) methamphetamine (EXP,ISO) methimazole (EXP) methotrexate (ISO) methyl methanesulfonate (ISO) methylseleninic acid (ISO) miconazole (ISO) mifepristone (ISO) mono(2-ethylhexyl) phthalate (ISO) N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO) N-methyl-4-phenylpyridinium (ISO) N-methyl-N'-nitro-N-nitrosoguanidine (ISO) N-nitrosodiethylamine (EXP,ISO) N-Nitrosopyrrolidine (ISO) nefazodone (EXP) nickel atom (ISO) niclosamide (ISO) nimesulide (EXP) oxaliplatin (EXP) ozone (ISO) paclitaxel (ISO) palbociclib (ISO) paracetamol (ISO) PCB138 (ISO) perfluorohexanesulfonic acid (ISO) perfluorononanoic acid (ISO) perfluorooctanoic acid (ISO) phenformin (EXP) phenobarbital (ISO) PhIP (EXP) phytoestrogen (ISO) picoxystrobin (ISO) pinosylvin (ISO) piperonyl butoxide (EXP) pirinixic acid (ISO) piroxicam (ISO) potassium dichromate (ISO) pregnenolone 16alpha-carbonitrile (EXP) progesterone (ISO) propanal (ISO) propiconazole (ISO) quercetin (ISO) resveratrol (ISO) rotenone (EXP,ISO) SB 431542 (ISO) serpentine asbestos (ISO) silicon dioxide (EXP,ISO) sodium arsenite (ISO) sodium dichromate (EXP,ISO) Soman (EXP) sulfadimethoxine (EXP) sulindac sulfide (ISO) sunitinib (ISO) tamibarotene (ISO) tebufenpyrad (ISO) testosterone (EXP,ISO) tetrachloromethane (ISO) tetraphene (ISO) thalidomide (ISO) thapsigargin (ISO) thioacetamide (EXP) thiram (ISO) titanium dioxide (EXP,ISO) tocopherol (ISO) toluene 2,4-diisocyanate (ISO) topotecan (EXP) trans-pinosylvin (ISO) Tributyltin oxide (ISO) triclosan (ISO) trimellitic anhydride (ISO) triptonide (ISO) triticonazole (EXP) troglitazone (ISO) trovafloxacin (EXP,ISO) Tungsten carbide (ISO) tunicamycin (ISO) valdecoxib (EXP) valproic acid (ISO) vincaleukoblastine (ISO) vincristine (ISO) zinc atom (ISO) zinc(0) (ISO) zoledronic acid (ISO)
1.
Oncogene amplification in the proximal part of chromosome 6 in rat endometrial adenocarcinoma as revealed by combined BAC/PAC FISH, chromosome painting, zoo-FISH, and allelotyping.
Adamovic T, etal., Genes Chromosomes Cancer. 2005 Oct;44(2):139-53.
2.
Tumor BRCA1, RRM1 and RRM2 mRNA expression levels and clinical response to first-line gemcitabine plus docetaxel in non-small-cell lung cancer patients.
Boukovinas I, etal., PLoS One. 2008;3(11):e3695. doi: 10.1371/journal.pone.0003695. Epub 2008 Nov 11.
3.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.
Replication of the hepatitis B virus requires a calcium-dependent HBx-induced G1 phase arrest of hepatocytes.
Gearhart TL and Bouchard MJ, Virology. 2010 Nov 10;407(1):14-25. Epub 2010 Aug 16.
5.
Potent siRNA inhibitors of ribonucleotide reductase subunit RRM2 reduce cell proliferation in vitro and in vivo.
Heidel JD, etal., Clin Cancer Res. 2007 Apr 1;13(7):2207-15.
6.
Cross-species comparison of orthologous gene expression in human bladder cancer and carcinogen-induced rodent models.
Lu Y, etal., Am J Transl Res. 2010 Sep 20;3(1):8-27.
7.
The regulation of ribonucleoside diphosphate reductase by the tumor promoter orotic acid in normal rat liver in vivo.
Manjeshwar S, etal., Mol Carcinog. 1999 Mar;24(3):188-96.
8.
KEGG Annotation Import Pipeline
Pipeline to import KEGG annotations from KEGG into RGD
9.
SMPDB Annotation Import Pipeline
Pipeline to import SMPDB annotations from SMPDB into RGD
10.
Gemcitabine-based chemogene therapy for pancreatic cancer using Ad-dCK::UMK GDEPT and TS/RR siRNA strategies.
Rejiba S, etal., Neoplasia. 2009 Jul;11(7):637-50.
11.
GOA pipeline
RGD automated data pipeline
12.
Data Import for Chemical-Gene Interactions
RGD automated import pipeline for gene-chemical interactions
13.
Comprehensive gene review and curation
RGD comprehensive gene curation
14.
Immunohistochemical detection of ribonucleotide reductase in human breast-tumors.
Saeki T, etal., Int J Oncol. 1995 Mar;6(3):523-9.
15.
Evidence that mammalian ribonucleotide reductase is a nuclear membrane associated glycoprotein.
Sikorska M, etal., Biochem Cell Biol. 1990 May;68(5):880-8.
16.
Changes in the cytoplasmic and nuclear activities of the ribonucleotide reductase holoenzyme and its subunits in regenerating liver cells in normal and thyroparathyroidectomized rats.
Youdale T, etal., Can J Biochem Cell Biol. 1984 Sep;62(9):914-9.
Rrm2 Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 6 47,044,755 - 47,075,370 (+) NCBI GRCr8 mRatBN7.2 6 41,339,858 - 41,346,774 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 6 41,340,557 - 41,346,773 (+) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 6 41,660,659 - 41,666,878 (+) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 6 41,975,466 - 41,981,683 (+) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 6 41,408,612 - 41,414,829 (+) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 6 43,884,627 - 43,890,818 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 6 43,884,678 - 43,889,515 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 6 60,756,160 - 60,762,351 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 6 42,350,541 - 42,356,748 (+) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 Celera 6 40,627,438 - 40,633,641 (+) NCBI Celera Cytogenetic Map 6 q16 NCBI
RRM2 Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 2 10,122,568 - 10,211,010 (+) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl 2 10,120,698 - 10,211,725 (+) Ensembl GRCh38 hg38 GRCh38 GRCh37 2 10,262,695 - 10,351,136 (+) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 2 10,180,184 - 10,188,074 (+) NCBI NCBI36 Build 36 hg18 NCBI36 Build 34 2 10,213,332 - 10,221,220 NCBI Celera 2 10,178,748 - 10,187,595 (+) NCBI Celera Cytogenetic Map 2 p25.1 NCBI HuRef 2 10,113,982 - 10,122,746 (+) NCBI HuRef CHM1_1 2 10,192,499 - 10,201,334 (+) NCBI CHM1_1 T2T-CHM13v2.0 2 10,151,280 - 10,239,549 (+) NCBI T2T-CHM13v2.0
Rrm2 Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 12 24,758,253 - 24,764,145 (+) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 12 24,758,240 - 24,764,145 (+) Ensembl GRCm39 Ensembl GRCm38 12 24,708,254 - 24,714,146 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 12 24,708,241 - 24,714,146 (+) Ensembl GRCm38 mm10 GRCm38 MGSCv37 12 25,393,119 - 25,399,011 (+) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 12 25,297,362 - 25,303,186 (+) NCBI MGSCv36 mm8 Celera 12 26,164,274 - 26,170,181 (+) NCBI Celera Cytogenetic Map 12 A1.3 NCBI cM Map 12 8.5 NCBI
Rrm2 Chinchilla Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChiLan1.0 Ensembl NW_004955487 5,476,954 - 5,483,049 (+) Ensembl ChiLan1.0 ChiLan1.0 NW_004955487 5,477,097 - 5,481,422 (+) NCBI ChiLan1.0 ChiLan1.0
RRM2 Bonobo Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl NHGRI_mPanPan1-v2 12 116,388,124 - 116,396,941 (-) NCBI NHGRI_mPanPan1-v2 NHGRI_mPanPan1 2A 116,392,095 - 116,400,912 (-) NCBI NHGRI_mPanPan1 Mhudiblu_PPA_v0 2A 10,119,508 - 10,128,318 (+) NCBI Mhudiblu_PPA_v0 Mhudiblu_PPA_v0 panPan3 PanPan1.1 2A 10,275,598 - 10,284,640 (+) NCBI panpan1.1 PanPan1.1 panPan2 PanPan1.1 Ensembl 2A 10,275,598 - 10,284,640 (+) Ensembl panpan1.1 panPan2
RRM2 Dog Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl CanFam3.1 17 7,106,515 - 7,113,868 (+) NCBI CanFam3.1 CanFam3.1 canFam3 CanFam3.1 CanFam3.1 Ensembl 17 7,104,961 - 7,122,939 (+) Ensembl CanFam3.1 canFam3 CanFam3.1 Dog10K_Boxer_Tasha 17 7,033,016 - 7,052,810 (+) NCBI Dog10K_Boxer_Tasha ROS_Cfam_1.0 17 7,204,147 - 7,223,928 (+) NCBI ROS_Cfam_1.0 ROS_Cfam_1.0 Ensembl 17 7,204,143 - 7,220,570 (+) Ensembl ROS_Cfam_1.0 Ensembl UMICH_Zoey_3.1 17 7,095,785 - 7,115,556 (+) NCBI UMICH_Zoey_3.1 UNSW_CanFamBas_1.0 17 7,098,343 - 7,118,126 (+) NCBI UNSW_CanFamBas_1.0 UU_Cfam_GSD_1.0 17 7,112,515 - 7,132,291 (+) NCBI UU_Cfam_GSD_1.0
Rrm2
RRM2
RRM2 Green Monkey Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChlSab1.1 14 97,512,690 - 97,519,734 (-) NCBI ChlSab1.1 ChlSab1.1 chlSab2 ChlSab1.1 Ensembl 14 97,512,832 - 97,521,932 (-) Ensembl ChlSab1.1 ChlSab1.1 Ensembl chlSab2 Vero_WHO_p1.0 NW_023666045 14,794,522 - 14,803,100 (+) NCBI Vero_WHO_p1.0 Vero_WHO_p1.0
Rrm2
.
Predicted Target Of
Count of predictions: 106 Count of miRNA genes: 98 Interacting mature miRNAs: 103 Transcripts: ENSRNOT00000011163 Prediction methods: Miranda Result types: miRGate_prediction
9590290 Uminl2 Urine mineral level QTL 2 3.96 0.001 urine mineral amount (VT:0015086) urine electrolyte level (CMO:0000593) 6 38783989 83783989 Rat 8693632 Alc27 Alcohol consumption QTL 27 2.2 0.791 drinking behavior trait (VT:0001422) calculated ethanol drink intake rate (CMO:0001615) 6 34323357 51121479 Rat 634318 Bw118 Body weight QTL 118 3.55 abdominal fat pad mass (VT:1000711) abdominal fat pad weight (CMO:0000088) 6 33309549 57730294 Rat 10401812 Kidm54 Kidney mass QTL 54 kidney mass (VT:0002707) both kidneys wet weight (CMO:0000085) 6 14368788 59368788 Rat 634307 Bp141 Blood pressure QTL 141 4 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 6 35230417 80230417 Rat 2292589 Emca10 Estrogen-induced mammary cancer QTL 10 0.048 mammary gland integrity trait (VT:0010552) post-insult time to mammary tumor formation (CMO:0000345) 6 16536140 61536140 Rat 10401800 Kidm49 Kidney mass QTL 49 kidney mass (VT:0002707) both kidneys wet weight (CMO:0000085) 6 14368788 59368788 Rat 1300164 Rf15 Renal function QTL 15 3.12 renal blood flow trait (VT:2000006) absolute change in renal blood flow rate (CMO:0001168) 6 5074497 54641141 Rat 1331779 Rf38 Renal function QTL 38 2.876 kidney blood vessel physiology trait (VT:0100012) absolute change in renal vascular resistance (CMO:0001900) 6 32074428 72227641 Rat 1354632 Scl29 Serum cholesterol level QTL 29 3.74 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) 6 35098709 71636405 Rat 4145119 Mcs25 Mammary carcinoma susceptibility QTL 25 0.0001 mammary gland integrity trait (VT:0010552) ratio of deaths to total study population during a period of time (CMO:0001023) 6 10894415 110548006 Rat 738024 Sach5 Saccharine consumption QTL 5 3.9 0.00039 consumption behavior trait (VT:0002069) saccharin intake volume to total fluid intake volume ratio (CMO:0001601) 6 1 43394190 Rat 2293839 Kiddil2 Kidney dilation QTL 2 4.8 kidney pelvis morphology trait (VT:0004194) hydronephrosis severity score (CMO:0001208) 6 20866422 81133036 Rat 1576309 Emca7 Estrogen-induced mammary cancer QTL 7 4 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) 6 15107216 107351382 Rat 9590140 Scort4 Serum corticosterone level QTL 4 14.49 0.001 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 6 38783989 83783989 Rat 2293709 Bss23 Bone structure and strength QTL 23 5.18 0.0001 femur morphology trait (VT:0000559) femur cross-sectional area (CMO:0001661) 6 1 42487980 Rat 2293650 Bss31 Bone structure and strength QTL 31 5.05 0.0001 femur strength trait (VT:0010010) femur midshaft polar moment of inertia (CMO:0001669) 6 1 42487980 Rat 9590306 Scort18 Serum corticosterone level QTL 18 2.88 0.001 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 6 38783989 83783989 Rat 7411584 Foco4 Food consumption QTL 4 4.3 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 6 1 42838846 Rat 1578665 Bss16 Bone structure and strength QTL 16 4.4 femur morphology trait (VT:0000559) bone trabecular cross-sectional area (CMO:0002311) 6 11735669 72593685 Rat 2293841 Kiddil4 Kidney dilation QTL 4 4.4 kidney pelvis morphology trait (VT:0004194) hydronephrosis severity score (CMO:0001208) 6 20866422 81133036 Rat 1641898 Colcr4 Colorectal carcinoma resistance QTL4 3.71 0.0007 intestine integrity trait (VT:0010554) well differentiated malignant colorectal tumor surface area measurement (CMO:0002077) 6 20338777 62613667 Rat 1578668 Bmd14 Bone mineral density QTL 14 3.8 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) 6 11735669 72593685 Rat 6893340 Cm77 Cardiac mass QTL 77 0.26 0.57 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) 6 33309549 81132889 Rat 70199 Coreg1 Compensatory renal growth QTL 1 11.8 kidney mass (VT:0002707) compensatory renal growth score (CMO:0001894) 6 35691618 57730540 Rat 2301972 Bp325 Blood pressure QTL 325 4.8 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 6 1 72227641 Rat 2293656 Bss28 Bone structure and strength QTL 28 6.79 0.0001 femur morphology trait (VT:0000559) femur midshaft cortical cross-sectional area (CMO:0001663) 6 1 42487980 Rat 1354664 Slep2 Serum leptin concentration QTL 2 4.49 blood leptin amount (VT:0005667) serum leptin level (CMO:0000780) 6 16536140 71636405 Rat 1300143 Rf14 Renal function QTL 14 2.92 renal blood flow trait (VT:2000006) absolute change in renal blood flow rate (CMO:0001168) 6 34434137 77102317 Rat
RH128375
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 19 23,879,602 - 23,879,800 (-) MAPPER mRatBN7.2 mRatBN7.2 6 41,346,372 - 41,346,570 (+) MAPPER mRatBN7.2 Rnor_6.0 6 43,890,417 - 43,890,614 NCBI Rnor6.0 Rnor_6.0 19 25,393,828 - 25,394,025 NCBI Rnor6.0 Rnor_5.0 19 36,370,006 - 36,370,203 UniSTS Rnor5.0 Rnor_5.0 6 60,761,950 - 60,762,147 UniSTS Rnor5.0 Celera 19 23,428,502 - 23,428,699 UniSTS Celera 6 40,633,240 - 40,633,437 UniSTS Cytogenetic Map 6 q16 UniSTS
RH137293
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 6 41,345,135 - 41,345,454 (+) MAPPER mRatBN7.2 mRatBN7.2 19 23,880,707 - 23,880,923 (-) MAPPER mRatBN7.2 Rnor_6.0 6 43,889,191 - 43,889,509 NCBI Rnor6.0 Rnor_6.0 19 25,392,702 - 25,392,917 NCBI Rnor6.0 Rnor_5.0 19 36,368,880 - 36,369,095 UniSTS Rnor5.0 Rnor_5.0 6 60,760,724 - 60,761,042 UniSTS Rnor5.0 Celera 19 23,429,607 - 23,429,822 UniSTS Celera 6 40,632,004 - 40,632,322 UniSTS Cytogenetic Map 6 q16 UniSTS
PMC207566P3
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 19 23,881,059 - 23,881,293 (-) MAPPER mRatBN7.2 Rnor_6.0 19 25,392,332 - 25,392,565 NCBI Rnor6.0 Rnor_5.0 19 36,368,510 - 36,368,743 UniSTS Rnor5.0 RGSC_v3.4 19 25,564,412 - 25,564,645 UniSTS RGSC3.4 Celera 19 23,429,959 - 23,430,192 UniSTS Cytogenetic Map 6 q16 UniSTS
Click on a value in the shaded box below the category label to view a detailed expression data table for that system.
alimentary part of gastrointestinal system
9
11
49
113
91
90
59
25
59
6
218
97
93
45
60
31
Too many to show, limit is 500. Download them if you would like to view them all.
Ensembl Acc Id:
ENSRNOT00000091551 ⟹ ENSRNOP00000073334
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 6 41,340,557 - 41,346,773 (+) Ensembl Rnor_6.0 Ensembl 6 43,884,678 - 43,889,515 (+) Ensembl
RefSeq Acc Id:
NM_001025740 ⟹ NP_001020911
RefSeq Status:
PROVISIONAL
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 6 47,069,167 - 47,075,370 (+) NCBI mRatBN7.2 6 41,340,569 - 41,346,774 (+) NCBI Rnor_6.0 6 43,884,627 - 43,890,818 (+) NCBI Rnor_5.0 6 60,756,160 - 60,762,351 (+) NCBI RGSC_v3.4 6 42,350,541 - 42,356,748 (+) RGD Celera 6 40,627,438 - 40,633,641 (+) RGD
Sequence:
TCCAGCTGTTCCCTCTTCTCCTCGTCCTCTCCACCTCTGCCTTCGTTCGCCATGCTCTCGGTCCGCGCCCCGCTCGCCACCATCGCTGACCAGCAGCAGCTGCACTTGTCGCCCCTGAAGCGACTCAG
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RefSeq Acc Id:
XM_039112489 ⟹ XP_038968417
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 6 47,066,082 - 47,075,370 (+) NCBI mRatBN7.2 6 41,339,858 - 41,346,774 (+) NCBI
RefSeq Acc Id:
XM_063262073 ⟹ XP_063118143
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 6 47,044,755 - 47,075,370 (+) NCBI
RefSeq Acc Id:
NP_001020911 ⟸ NM_001025740
- UniProtKB:
Q4KLN6 (UniProtKB/Swiss-Prot), A6HAY1 (UniProtKB/TrEMBL)
- Sequence:
MLSVRAPLATIADQQQLHLSPLKRLSLADKENTPPTLSSARVLASKAARRIFQDSAELESKAPTKPSIEEEPLLRENPRRFVVFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWEALKPDERHFI
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Ensembl Acc Id:
ENSRNOP00000073334 ⟸ ENSRNOT00000091551
RefSeq Acc Id:
XP_038968417 ⟸ XM_039112489
- Peptide Label:
isoform X1
- UniProtKB:
A0A8L2R734 (UniProtKB/TrEMBL)
RefSeq Acc Id:
XP_063118143 ⟸ XM_063262073
- Peptide Label:
isoform X2
- UniProtKB:
Q4KLN6 (UniProtKB/Swiss-Prot), A6HAY1 (UniProtKB/TrEMBL)
RGD ID: 13694523 Promoter ID: EPDNEW_R5046 Type: multiple initiation site Name: Rrm2_1 Description: ribonucleotide reductase regulatory subunit M2 SO ACC ID: SO:0000170 Source: EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/ ) Experiment Methods: Single-end sequencing. Position: Rat Assembly Chr Position (strand) Source Rnor_6.0 6 43,884,618 - 43,884,678 EPDNEW
Date
Current Symbol
Current Name
Previous Symbol
Previous Name
Description
Reference
Status
2016-01-21
Rrm2
ribonucleotide reductase regulatory subunit M2
Rrm2
ribonucleotide reductase M2
Nomenclature updated to reflect human and mouse nomenclature
1299863 APPROVED
2007-04-13
ribonucleotide reductase M2
Rrm2
ribonucleotide reductase M2 (mapped)
Name updated
737654 APPROVED
2007-04-12
Rrm2
ribonucleotide reductase M2 (mapped)
Rrm2_mapped
ribonucleotide reductase M2 (mapped)
Data merged from RGD:3605
737654 APPROVED
2006-11-20
Rrm2
ribonucleotide reductase M2 (mapped)
Symbol and Name status set to provisional
70820 PROVISIONAL
2005-11-17
Rrm2_mapped
ribonucleotide reductase M2 (mapped)
Symbol and Name updated
1556543 APPROVED
2002-06-10
Rrm2
Ribonucleotide reductase 2
Symbol and Name status set to approved
70586 APPROVED
Note Type
Note
Reference
gene_process
human homolog is required for formation of deoxyribonucleotides from ribonucleotides
704404
