Atm (ATM serine/threonine kinase) - Rat Genome Database

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Gene: Atm (ATM serine/threonine kinase) Rattus norvegicus
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Symbol: Atm
Name: ATM serine/threonine kinase
RGD ID: 1593265
Description: Predicted to enable identical protein binding activity and phosphotransferase activity, alcohol group as acceptor. Involved in several processes, including cellular response to ionizing radiation; positive regulation of DNA catabolic process; and regulation of microglial cell activation. Predicted to be located in chromosome, telomeric region; microtubule cytoskeleton; and nuclear lumen. Predicted to be part of DNA repair complex. Predicted to be active in nucleus; peroxisomal matrix; and site of double-strand break. Predicted to be extrinsic component of synaptic vesicle membrane. Used to study ataxia telangiectasia; disease of cellular proliferation; infertility; leukemia; and lymphoma. Biomarker of pre-malignant neoplasm and status epilepticus. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); endocrine gland cancer (multiple); lung carcinoma (multiple); neurodegenerative disease (multiple); and senile cataract. Orthologous to human ATM (ATM serine/threonine kinase); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; homologous recombination pathway of double-strand break repair; nuclear factor kappa B signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-amino-2-deoxy-D-galactopyranose.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ataxia telangiectasia gene mutated in human beings; ataxia telangiectasia mutated; ataxia telangiectasia mutated homolog; ataxia telangiectasia mutated homolog (human); ataxia telangiectasia mutated homolog (human) (mapped); Atm_mapped; serine-protein kinase ATM
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Atmm1Kyo   Atmem1Kyo  
Genetic Models: F344-Atmm1Kyo F344-Atmem1Kyo
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8862,724,939 - 62,829,040 (-)NCBIGRCr8
mRatBN7.2853,828,741 - 53,932,773 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl853,831,093 - 53,932,437 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx859,356,470 - 59,457,803 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0857,635,498 - 57,736,825 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0855,499,734 - 55,601,064 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0858,015,938 - 58,119,973 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl858,015,940 - 58,120,045 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0856,598,503 - 56,703,115 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4856,894,746 - 56,996,565 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera853,321,802 - 53,423,212 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Object Symbol
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Original Reference(s)
AtmRatAcute Liver Failure treatmentIEP 10053604 RGD 
AtmRatAcute Liver Failure treatmentISOAtm (Mus musculus)10053606 RGD 
AtmRatAlzheimer's disease disease_progressionISOATM (Homo sapiens)10047419 RGD 
AtmRatArenaviridae infectious disease  ISOAtm (Mus musculus)126779561 RGD 
AtmRatarteriosclerosis susceptibilityISOAtm (Mus musculus)1601249 RGD 
AtmRatataxia telangiectasia  ISOAtm (Mus musculus)10053611 RGD 
AtmRatataxia telangiectasia  IMP 12879399DNA:deletion:exon:RGD 
AtmRatbreast cancer susceptibilityISOATM (Homo sapiens)1643350 RGD 
AtmRatbreast carcinoma disease_progressionISOATM (Homo sapiens)1643351protein:decreased expression:lymph nodeRGD 
AtmRatcolorectal cancer disease_progressionISOATM (Homo sapiens)126790575 RGD 
AtmRatcolorectal cancer  ISOATM (Homo sapiens)150340701mRNA:decreased expression:mucosa of rectum (human)RGD 
AtmRatcolorectal cancer disease_progressionISOATM (Homo sapiens)150340714DNA:mutationsRGD 
AtmRatdisease of cellular proliferation  IMP 12879399 RGD 
AtmRatdisease of cellular proliferation  IMP 12879393 RGD 
AtmRatendometrial cancer susceptibilityISOATM (Homo sapiens)2293868 RGD 
AtmRatesophagus squamous cell carcinoma disease_progressionISOATM (Homo sapiens)150340713Smoke Inhalation Injury and mRNA:increased expression:esophagus (human)RGD 
AtmRatExperimental Colitis exacerbatesISOAtm (Mus musculus)126781749 RGD 
AtmRatfemale breast cancer susceptibilityISOATM (Homo sapiens)152995259DNA:missense mutation:cds: (human)RGD 
AtmRatGastro-Enteropancreatic Neuroendocrine Tumor disease_progressionISOATM (Homo sapiens)150340716associated with Neoplasm Metastasis more ...RGD 
AtmRatHelicobacter Infections  ISOATM (Homo sapiens)126790563associated with stomach cancer and mRNA:increased expression:stomach (human)RGD 
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Original Reference(s)
AtmRatadenocarcinoma  ISOATM (Homo sapiens)8554872ClinVar Annotator: match by term: AdenocarcinomaClinVarPMID:10330348 more ...
AtmRatastroblastoma, MN1-altered  ISOATM (Homo sapiens)8554872ClinVar Annotator: match by term: Astroblastoma and MN1-alteredClinVarPMID:17344846 more ...
AtmRatataxia telangiectasia  ISOATM (Homo sapiens)8554872ClinVar more ...ClinVarPMID:34653365 more ...
AtmRatataxia telangiectasia  ISOATM (Homo sapiens)8554872ClinVar more ...ClinVarPMID:31248605 more ...
AtmRatataxia telangiectasia  ISOATM (Homo sapiens)8554872ClinVar more ...ClinVarPMID:100011 more ...
AtmRatataxia telangiectasia  ISOATM (Homo sapiens)8554872ClinVar more ...ClinVarPMID:31422574 more ...
AtmRatataxia telangiectasia  ISOATM (Homo sapiens)8554872ClinVar more ...ClinVarPMID:27871447 more ...
AtmRatataxia telangiectasia  ISOATM (Homo sapiens)8554872ClinVar more ...ClinVarPMID:22420423 more ...
AtmRatataxia telangiectasia  ISOATM (Homo sapiens)8554872ClinVar more ...ClinVarPMID:35245693 more ...
AtmRatataxia telangiectasia  ISOATM (Homo sapiens)8554872ClinVar more ...ClinVarPMID:22438227 more ...
AtmRatataxia telangiectasia  ISOATM (Homo sapiens)8554872ClinVar more ...ClinVarPMID:31428572 more ...
AtmRatataxia telangiectasia  ISOATM (Homo sapiens)8554872ClinVar more ...ClinVarPMID:27854218 more ...
AtmRatataxia telangiectasia  ISOATM (Homo sapiens)8554872ClinVar more ...ClinVarPMID:35257272 more ...
AtmRatataxia telangiectasia  ISOATM (Homo sapiens)8554872ClinVar more ...ClinVarPMID:100011 more ...
AtmRatataxia telangiectasia  ISOATM (Homo sapiens)8554872ClinVar more ...ClinVarPMID:31470354 more ...
AtmRatataxia telangiectasia  ISOATM (Homo sapiens)8554872ClinVar more ...ClinVarPMID:27873105 more ...
AtmRatataxia telangiectasia  ISOATM (Homo sapiens)8554872ClinVar more ...ClinVarPMID:22438227 more ...
AtmRatataxia telangiectasia  ISOATM (Homo sapiens)8554872ClinVar more ...ClinVarPMID:100011 more ...
AtmRatataxia telangiectasia  ISOATM (Homo sapiens)8554872ClinVar more ...ClinVarPMID:35534704 more ...
AtmRatataxia telangiectasia  ISOATM (Homo sapiens)8554872ClinVar more ...ClinVarPMID:31776720 more ...
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Original Reference(s)
AtmRatadenoid cystic carcinoma  ISOATM (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23685749
AtmRatataxia telangiectasia  ISOATM (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:8958160 more ...
AtmRatB-Cell Chronic Lymphocytic Leukemia  ISOATM (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17968022
AtmRatBreast Neoplasms  ISOATM (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
AtmRatcataract  ISOATM (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16799786
AtmRatdilated cardiomyopathy  ISOATM (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24358288
AtmRatdisease of cellular proliferation  ISOATM (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21177254
AtmRatFamilial Prostate Cancer  ISOATM (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29892016
AtmRatFibrosis  ISOATM (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24358288
AtmRathepatocellular carcinoma  ISOATM (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19919837
AtmRatliver cirrhosis  ISOATM (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:36526012
AtmRatmelanoma  ISOATM (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21983787
AtmRatmyocardial infarction  ISOATM (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24358288
AtmRatpancreatic cancer  ISOATM (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26098866 and PMID:26098869
AtmRatperipheral T-cell lymphoma  ISOATM (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24413734
AtmRatPrenatal Exposure Delayed Effects  ISOATM (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21177254
AtmRatprimary cutaneous T-cell non-Hodgkin lymphoma  ISOATM (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26192916
AtmRatProstatic Neoplasms  ISOATM (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17502119 more ...
AtmRatsquamous cell carcinoma  ISOATM (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25125259
AtmRatStomach Neoplasms  ISOATM (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26098866
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Original Reference(s)
AtmRatataxia telangiectasia  ISSAtm (Mus musculus)13592920OMIM:208900MouseDO 
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Original Reference(s)
AtmRatataxia telangiectasia susceptibilityISOATM (Homo sapiens)7240710 OMIM 
AtmRatbreast cancer susceptibilityISOATM (Homo sapiens)7240710 OMIM 

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Original Reference(s)
AtmRat(+)-catechin multiple interactionsISOATM (Homo sapiens)6480464Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of ATM mRNA]CTDPMID:21882252
AtmRat(1->4)-beta-D-glucan multiple interactionsISOAtm (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of ATM mRNACTDPMID:36331819
AtmRat(1S)-bornane-2,3-dione increases phosphorylationISOATM (Homo sapiens)6480464camphorquinone results in increased phosphorylation of ATM proteinCTDPMID:26658076
AtmRat(S)-naringenin multiple interactionsISOATM (Homo sapiens)6480464[naringenin co-treated with bisphenol A] results in increased expression of ATM mRNA and [naringenin metabolite co-treated with bisphenol A] results in increased expression of ATM mRNACTDPMID:36235125
AtmRat(S)-nicotine multiple interactionsISOATM (Homo sapiens)6480464Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of ATM protein modified form]CTDPMID:23907605
AtmRat1,2-dichloroethane decreases expressionISOAtm (Mus musculus)6480464ethylene dichloride results in decreased expression of ATM mRNACTDPMID:28960355
AtmRat1,2-dimethylhydrazine affects expressionISOAtm (Mus musculus)64804641 and 2-Dimethylhydrazine affects the expression of ATM mRNACTDPMID:22206623
AtmRat17beta-estradiol decreases expressionISOAtm (Mus musculus)6480464Estradiol results in decreased expression of ATM mRNACTDPMID:22467019
AtmRat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of ATM mRNACTDPMID:32145629
AtmRat17beta-estradiol decreases expressionISOATM (Homo sapiens)6480464Estradiol results in decreased expression of ATM mRNACTDPMID:24481588
AtmRat17beta-estradiol increases expressionISOATM (Homo sapiens)6480464Estradiol results in increased expression of ATM mRNA and Estradiol results in increased expression of ATM protein modified formCTDPMID:25933419 and PMID:36581016
AtmRat17beta-hydroxy-17-methylestra-4,9,11-trien-3-one multiple interactionsISOATM (Homo sapiens)6480464[ATM mutant form inhibits the reaction [Metribolone results in increased expression of H2AX protein]] which results in increased expression of ERG mRNA and ATM mutant form inhibits the reaction [Metribolone results in increased expression of H2AX protein]CTDPMID:23272087
AtmRat17beta-hydroxy-17-methylestra-4,9,11-trien-3-one increases phosphorylationISOATM (Homo sapiens)6480464Metribolone results in increased phosphorylation of ATM proteinCTDPMID:23272087
AtmRat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISOAtm (Mus musculus)6480464[2 more ...CTDPMID:25510870
AtmRat2,2',4,4'-Tetrabromodiphenyl ether affects expressionISOATM (Homo sapiens)64804642 more ...CTDPMID:26988655
AtmRat2,2',4,4'-Tetrabromodiphenyl ether multiple interactionsISOAtm (Mus musculus)6480464[Flame Retardants results in increased abundance of 2 more ...CTDPMID:38995820
AtmRat2,2',5,5'-tetrachlorobiphenyl multiple interactionsISOAtm (Mus musculus)6480464[2 more ...CTDPMID:25510870
AtmRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOAtm (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of ATM mRNACTDPMID:16922920
AtmRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of ATM mRNACTDPMID:33387578
AtmRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of ATM mRNACTDPMID:34747641

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Biological Process
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Original Reference(s)
AtmRatbrain development acts_upstream_of_or_withinISOAtm (Mus musculus)1624291MGI:104779 PMID:16687486RGDPMID:16687486
AtmRatcellular response to gamma radiation involved_inISOATM (Homo sapiens)1624291 PMID:16213212 and PMID:9925639RGDPMID:16213212 and PMID:9925639
AtmRatcellular response to ionizing radiation  IMP 12879399 RGD 
AtmRatcellular response to nitrosative stress involved_inISOATM (Homo sapiens)1624291 PMID:23878245RGDPMID:23878245
AtmRatcellular response to reactive oxygen species involved_inISOATM (Homo sapiens)1624291 PMID:26344566RGDPMID:26344566
AtmRatcellular response to retinoic acid involved_inISOAtm (Mus musculus)1624291 PMID:20876357RGDPMID:20876357
AtmRatcellular response to stress involved_inISOATM (Homo sapiens)1624291 PMID:37943659RGDPMID:37943659
AtmRatcellular response to X-ray involved_inISOATM (Homo sapiens)1624291 PMID:26323318RGDPMID:26323318
AtmRatchromatin remodeling involved_inIEAGO:00359791600115GO_REF:0000108GOCGO_REF:0000108
AtmRatchromosome organization involved in meiotic cell cycle acts_upstream_of_or_withinISOAtm (Mus musculus)1624291MGI:1926343 PMID:8843194RGDPMID:8843194
AtmRatdetermination of adult lifespan acts_upstream_of_or_withinISOAtm (Mus musculus)1624291MGI:3605986 more ...RGDPMID:19061978
AtmRatDNA damage checkpoint signaling involved_inISOATM (Homo sapiens)1624291 PMID:30886146RGDPMID:30886146
AtmRatDNA damage checkpoint signaling acts_upstream_of_or_withinISOAtm (Mus musculus)1624291 PMID:12937170RGDPMID:12937170
AtmRatDNA damage checkpoint signaling involved_inIBAFB:FBgn0004367 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
AtmRatDNA damage response  IMP 2316101 RGD 
AtmRatDNA damage response involved_inIEAUniProtKB-KW:KW-02271600115GO_REF:0000043UniProtGO_REF:0000043
AtmRatDNA damage response acts_upstream_of_or_withinISOAtm (Mus musculus)1624291MGI:3605986 more ...RGDPMID:19061978
AtmRatDNA damage response involved_inIEAInterPro:IPR038980 and InterPro:IPR0441071600115GO_REF:0000002InterProGO_REF:0000002
AtmRatDNA damage response involved_inISOATM (Homo sapiens)1624291 PMID:16213212 more ...RGDPMID:16213212 more ...
AtmRatDNA damage response  IMP 10053571 RGD 
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Cellular Component
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Original Reference(s)
AtmRatcentrosome located_inISOAtm (Mus musculus)1624291 PMID:25936915RGDPMID:25936915
AtmRatchromosome is_active_inIBAMGI:108028 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
AtmRatchromosome, telomeric region located_inISOATM (Homo sapiens)1624291 PMID:15149599RGDPMID:15149599
AtmRatcytoplasm located_inISOAtm (Mus musculus)1624291 PMID:29955025RGDPMID:29955025
AtmRatcytoplasm is_active_inIBAMGI:107202 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
AtmRatcytoplasmic vesicle located_inIEAUniProtKB-KW:KW-09681600115GO_REF:0000043UniProtGO_REF:0000043
AtmRatDNA repair complex part_ofISOATM (Homo sapiens)1624291 PMID:24217620RGDPMID:24217620
AtmRatextrinsic component of synaptic vesicle membrane is_active_inISOAtm (Mus musculus)1624291 PMID:27075534RGDPMID:27075534
AtmRatintracellular membrane-bounded organelle located_inISOATM (Homo sapiens)1624291 RGDGO_REF:0000052
AtmRatnucleolus located_inISOATM (Homo sapiens)1624291 PMID:27829214RGDPMID:27829214
AtmRatnucleoplasm located_inISOATM (Homo sapiens)1624291 RGDGO_REF:0000052
AtmRatnucleus is_active_inIBAFB:FBgn0045035 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
AtmRatnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
AtmRatnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
AtmRatnucleus located_inISOATM (Homo sapiens)1624291 PMID:26323318RGDPMID:26323318
AtmRatnucleus located_inISOAtm (Mus musculus)1624291 PMID:29955025RGDPMID:29955025
AtmRatperoxisomal matrix is_active_inISOATM (Homo sapiens)1624291 PMID:26344566RGDPMID:26344566
AtmRatsite of double-strand break is_active_inISOATM (Homo sapiens)1624291 PMID:26240375RGDPMID:26240375
AtmRatspindle located_inISOAtm (Mus musculus)1624291 PMID:15509711RGDPMID:15509711
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Molecular Function
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Original Reference(s)
AtmRat1-phosphatidylinositol-3-kinase activity enablesISOATM (Homo sapiens)1624291 PMID:11375976RGDPMID:11375976
AtmRatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
AtmRatDNA-dependent protein kinase activity enablesISOATM (Homo sapiens)1624291 PMID:15790808RGDPMID:15790808
AtmRathistone H2AXS139 kinase activity enablesISOAtm (Mus musculus)1624291 PMID:11571274RGDPMID:11571274
AtmRatidentical protein binding enablesISOATM (Homo sapiens)1624291UniProtKB:Q13315 and PMID:15790808RGDPMID:15790808
AtmRatkinase activity enablesIEAUniProtKB-KW:KW-04181600115GO_REF:0000043UniProtGO_REF:0000043
AtmRatkinase activity enablesIEAInterPro:IPR0189361600115GO_REF:0000002InterProGO_REF:0000002
AtmRatnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
AtmRatprotein binding enablesISOATM (Homo sapiens)1624291UniProtKB:O43156 more ...RGDPMID:11375976 more ...
AtmRatprotein binding enablesISOAtm (Mus musculus)1624291UniProtKB:Q9D1M4 and PMID:15680327RGDPMID:15680327
AtmRatprotein kinase activity enablesISOAtm (Mus musculus)1624291 PMID:10710310 and PMID:15364958RGDPMID:10710310 and PMID:15364958
AtmRatprotein serine/threonine kinase activity enablesIEAEC:2.7.11.11600115GO_REF:0000003UniProtGO_REF:0000003
AtmRatprotein serine/threonine kinase activity enablesISOATM (Homo sapiens)1624291 PMID:10766245 more ...RGDPMID:10766245 more ...
AtmRatprotein serine/threonine kinase activity enablesIEAInterPro:IPR021668 more ...1600115GO_REF:0000002InterProGO_REF:0000002
AtmRatprotein serine/threonine kinase activity enablesIBAMGI:104779 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
AtmRatprotein serine/threonine kinase activity enablesIEAUniProtKB-KW:KW-07231600115GO_REF:0000043UniProtGO_REF:0000043
AtmRatprotein-containing complex binding enablesISOATM (Homo sapiens)1624291 PMID:15790808RGDPMID:15790808
AtmRattransferase activity enablesIEAUniProtKB-KW:KW-08081600115GO_REF:0000043UniProtGO_REF:0000043
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RGD Manual Annotations


  

Imported Annotations - KEGG (archival)

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Original Reference(s)
AtmRatapoptotic cell death pathway  IEA 6907045 KEGGrno:04210
AtmRatcell cycle pathway, mitotic  IEA 6907045 KEGGrno:04110
AtmRatp53 signaling pathway   IEA 6907045 KEGGrno:04115

Imported Annotations - PID (archival)

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Original Reference(s)
AtmRatnuclear factor kappa B signaling pathway   ISOATM (Homo sapiens)6484113 PIDPID:200031
AtmRatp38 MAPK signaling pathway   ISOATM (Homo sapiens)6484113 PIDPID:200018
AtmRatp53 signaling pathway   ISOATM (Homo sapiens)6484113 PIDPID:200206
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Reference Title
Reference Citation
1. Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinoma. Akulevich NM, etal., Endocr Relat Cancer. 2009 Jun;16(2):491-503. doi: 10.1677/ERC-08-0336. Epub 2009 Mar 13.
2. Inhibition of ataxia telangiectasia mutated (ATM) kinase suppresses herpes simplex virus type 1 (HSV-1) keratitis. Alekseev O, etal., Invest Ophthalmol Vis Sci. 2014 Feb 3;55(2):706-15. doi: 10.1167/iovs.13-13461.
3. ATM protein overexpression in prostate tumors: possible role in telomere maintenance. Angele S, etal., Am J Clin Pathol. 2004 Feb;121(2):231-6.
4. Histopathological features of breast cancer in carriers of ATM gene variants. Balleine RL, etal., Histopathology. 2006 Nov;49(5):523-32.
5. Perturbations in ataxia telangiectasia mutant signaling pathways after drug-induced acute liver failure and their reversal during rescue of animals by cell therapy. Bandi S, etal., Am J Pathol. 2011 Jan;178(1):161-74. doi: 10.1016/j.ajpath.2010.11.001. Epub 2010 Dec 23.
6. ATM protein kinase: the linchpin of cellular defenses to stress. Bhatti S, etal., Cell Mol Life Sci. 2011 Sep;68(18):2977-3006. doi: 10.1007/s00018-011-0683-9. Epub 2011 May 2.
7. The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma. Bose S, etal., J Pathol. 2009 Feb;217(3):345-52. doi: 10.1002/path.2487.
8. Activation of ataxia telangiectasia muted under experimental models and human Parkinson's disease. Camins A, etal., Cell Mol Life Sci. 2010 Nov;67(22):3865-82. doi: 10.1007/s00018-010-0408-5. Epub 2010 May 26.
9. Aberrant CD8+ T-cell responses and memory differentiation upon viral infection of an ataxia-telangiectasia mouse model driven by hyper-activated Akt and mTORC1 signaling. D'Souza AD, etal., Am J Pathol. 2011 Jun;178(6):2740-51. doi: 10.1016/j.ajpath.2011.02.022.
10. B Cell-Specific Expression of Ataxia-Telangiectasia Mutated Protein Kinase Promotes Chronic Gammaherpesvirus Infection. Darrah EJ, etal., J Virol. 2017 Sep 12;91(19). pii: JVI.01103-17. doi: 10.1128/JVI.01103-17. Print 2017 Oct 1.
11. Effect of ATM, CHEK2 and ERBB2 TAGSNPs and haplotypes on endometrial cancer risk. Einarsdottir K, etal., Hum Mol Genet. 2007 Jan 15;16(2):154-64. Epub 2006 Dec 12.
12. Loss of the DNA Damage Repair Kinase ATM Impairs Inflammasome-Dependent Anti-Bacterial Innate Immunity. Erttmann SF, etal., Immunity. 2016 Jul 19;45(1):106-18. doi: 10.1016/j.immuni.2016.06.018. Epub 2016 Jul 12.
13. ATM activation is accompanied with earlier stages of prostate tumorigenesis. Fan C, etal., Biochim Biophys Acta. 2006 Oct;1763(10):1090-7. Epub 2006 Aug 24.
14. Anthracyclines induce DNA damage response-mediated protection against severe sepsis. Figueiredo N, etal., Immunity. 2013 Nov 14;39(5):874-84. doi: 10.1016/j.immuni.2013.08.039. Epub 2013 Oct 31.
15. Deficiency of ataxia telangiectasia mutated kinase modulates cardiac remodeling following myocardial infarction: involvement in fibrosis and apoptosis. Foster CR, etal., PLoS One. 2013 Dec 16;8(12):e83513. doi: 10.1371/journal.pone.0083513. eCollection 2013.
16. Glycine propionyl l-carnitine attenuates d-Galactosamine induced fulminant hepatic failure in wistar rats. Ganai AA, etal., Chem Biol Interact. 2014 May 5;214:33-40. doi: 10.1016/j.cbi.2014.02.006. Epub 2014 Feb 22.
17. Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation. Gatei M, etal., J Biol Chem 2003 Apr 25;278(17):14806-11. Epub 2003 Feb 14.
18. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
19. Familial breast cancer and DNA repair genes: Insights into known and novel susceptibility genes from the GENESIS study, and implications for multigene panel testing. Girard E, etal., Int J Cancer. 2019 Apr 15;144(8):1962-1974. doi: 10.1002/ijc.31921. Epub 2018 Nov 13.
20. DNA damage induced by polyglutamine-expanded proteins. Giuliano P, etal., Hum Mol Genet. 2003 Sep 15;12(18):2301-9. Epub 2003 Jul 22.
1 to 20 of 77 rows
PMID:8843194   PMID:9733515   PMID:9925639   PMID:10639175   PMID:10710310   PMID:11040211   PMID:11248063   PMID:11375976   PMID:11536012   PMID:11679583   PMID:11943150   PMID:12937170  
PMID:15149599   PMID:15364958   PMID:15509711   PMID:15542845   PMID:15640358   PMID:15790808   PMID:15916964   PMID:16086026   PMID:16213212   PMID:16687486   PMID:16777961   PMID:17010969  
PMID:17476307   PMID:17694070   PMID:17875758   PMID:18162465   PMID:18571408   PMID:19061978   PMID:19208651   PMID:19448632   PMID:20096447   PMID:20111719   PMID:20213763   PMID:20876357  
PMID:21186350   PMID:22505033   PMID:23836881   PMID:23878245   PMID:24217620   PMID:24550317   PMID:24610783   PMID:26323318   PMID:26586427   PMID:26586433   PMID:27664052   PMID:27829214  
PMID:28220272   PMID:28344092   PMID:28894083   PMID:29203878   PMID:30612738   PMID:30886180   PMID:31315051   PMID:31401888   PMID:32810137   PMID:38774923  



Atm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8862,724,939 - 62,829,040 (-)NCBIGRCr8
mRatBN7.2853,828,741 - 53,932,773 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl853,831,093 - 53,932,437 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx859,356,470 - 59,457,803 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0857,635,498 - 57,736,825 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0855,499,734 - 55,601,064 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0858,015,938 - 58,119,973 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl858,015,940 - 58,120,045 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0856,598,503 - 56,703,115 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4856,894,746 - 56,996,565 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera853,321,802 - 53,423,212 (-)NCBICelera
Cytogenetic Map8q24NCBI
ATM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811108,223,067 - 108,369,102 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11108,222,804 - 108,369,102 (+)EnsemblGRCh38hg38GRCh38
GRCh3711108,093,794 - 108,239,829 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611107,598,769 - 107,745,036 (+)NCBINCBI36Build 36hg18NCBI36
Celera11105,248,510 - 105,394,764 (+)NCBICelera
Cytogenetic Map11q22.3NCBI
HuRef11104,019,183 - 104,165,444 (+)NCBIHuRef
CHM1_111107,976,660 - 108,122,959 (+)NCBICHM1_1
T2T-CHM13v2.011108,230,362 - 108,376,596 (+)NCBIT2T-CHM13v2.0
Atm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39953,348,422 - 53,448,125 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl953,350,449 - 53,448,040 (-)EnsemblGRCm39 Ensembl
GRCm38953,437,122 - 53,536,828 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl953,439,149 - 53,536,740 (-)EnsemblGRCm38mm10GRCm38
MGSCv37953,245,227 - 53,344,776 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36953,201,763 - 53,298,968 (-)NCBIMGSCv36mm8
Celera950,696,862 - 50,796,451 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map929.12NCBI
Atm
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541210,426,135 - 10,530,545 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541210,422,753 - 10,531,406 (+)NCBIChiLan1.0ChiLan1.0
ATM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29108,968,082 - 109,114,865 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111110,061,127 - 110,207,606 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011103,109,979 - 103,256,405 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111106,584,228 - 106,728,457 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11106,584,228 - 106,727,041 (+)Ensemblpanpan1.1panPan2
ATM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1524,180,129 - 24,297,207 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl524,182,135 - 24,297,207 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha524,107,778 - 24,222,696 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0524,211,375 - 24,326,057 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl524,211,375 - 24,326,057 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1524,258,890 - 24,373,424 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0524,160,300 - 24,274,920 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0524,218,488 - 24,333,125 (-)NCBIUU_Cfam_GSD_1.0
Atm
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494791,001,856 - 91,178,286 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936551359,362 - 532,211 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936551359,134 - 534,672 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl936,620,657 - 36,759,552 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1936,620,656 - 36,759,555 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2940,746,630 - 40,837,766 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2940,926,043 - 40,945,434 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1199,653,208 - 99,786,889 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl199,653,139 - 99,791,520 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604326,170,879 - 26,305,849 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atm
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247842,937,499 - 3,078,216 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247842,933,172 - 3,080,131 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Atm
716 total Variants

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:41
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000050555
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 55 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat

1 to 10 of 55 rows
RH143065  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2853,921,312 - 53,921,471 (+)MAPPERmRatBN7.2
Rnor_6.0858,108,501 - 58,108,659NCBIRnor6.0
Rnor_5.0856,691,121 - 56,691,279UniSTSRnor5.0
RGSC_v3.4856,985,443 - 56,985,601UniSTSRGSC3.4
Celera853,412,090 - 53,412,248UniSTS
RH 3.4 Map8583.1UniSTS
Cytogenetic Map8q24UniSTS
RH135390  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2853,920,992 - 53,921,186 (+)MAPPERmRatBN7.2
Rnor_6.0858,108,181 - 58,108,374NCBIRnor6.0
Rnor_5.0856,690,801 - 56,690,994UniSTSRnor5.0
RGSC_v3.4856,985,123 - 56,985,316UniSTSRGSC3.4
Celera853,411,770 - 53,411,963UniSTS
RH 3.4 Map8582.5UniSTS
Cytogenetic Map8q24UniSTS
RH141713  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2853,829,570 - 53,829,754 (+)MAPPERmRatBN7.2
Rnor_6.0858,016,768 - 58,016,951NCBIRnor6.0
Rnor_5.0856,599,333 - 56,599,516UniSTSRnor5.0
RGSC_v3.4856,893,224 - 56,893,407UniSTSRGSC3.4
Celera853,320,280 - 53,320,463UniSTS
RH 3.4 Map8584.7UniSTS
Cytogenetic Map8q24UniSTS


This gene Atm is modified in the following models/strains:
F344-Atmm1Kyo     F344-Atmem1Kyo    




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000050555   ⟹   ENSRNOP00000045529
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl853,831,093 - 53,932,437 (-)Ensembl
Rnor_6.0 Ensembl858,018,290 - 58,119,623 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086812   ⟹   ENSRNOP00000072646
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl858,015,940 - 58,120,045 (-)Ensembl
RefSeq Acc Id: NM_001106821   ⟹   NP_001100291
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8862,727,291 - 62,828,629 (-)NCBI
mRatBN7.2853,831,093 - 53,932,437 (-)NCBI
Rnor_6.0858,018,290 - 58,119,623 (-)NCBI
Rnor_5.0856,598,503 - 56,703,115 (-)NCBI
RGSC_v3.4856,894,746 - 56,996,565 (-)RGD
Celera853,321,802 - 53,423,212 (-)RGD
Sequence:
RefSeq Acc Id: XM_008766222   ⟹   XP_008764444
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8862,724,939 - 62,828,984 (-)NCBI
mRatBN7.2853,828,741 - 53,932,770 (-)NCBI
Rnor_6.0858,015,938 - 58,119,957 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039081068   ⟹   XP_038936996
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8862,724,939 - 62,828,984 (-)NCBI
mRatBN7.2853,828,741 - 53,932,770 (-)NCBI
RefSeq Acc Id: XM_039081069   ⟹   XP_038936997
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8862,724,939 - 62,829,040 (-)NCBI
mRatBN7.2853,828,741 - 53,932,760 (-)NCBI
RefSeq Acc Id: XM_039081070   ⟹   XP_038936998
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8862,724,939 - 62,828,987 (-)NCBI
mRatBN7.2853,828,741 - 53,932,753 (-)NCBI
RefSeq Acc Id: XM_039081072   ⟹   XP_038937000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8862,724,939 - 62,807,499 (-)NCBI
mRatBN7.2853,828,741 - 53,911,306 (-)NCBI
RefSeq Acc Id: XM_039081074   ⟹   XP_038937002
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8862,751,470 - 62,828,984 (-)NCBI
mRatBN7.2853,855,277 - 53,932,773 (-)NCBI
RefSeq Acc Id: XM_063265114   ⟹   XP_063121184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8862,806,193 - 62,828,984 (-)NCBI
RefSeq Acc Id: XM_063265115   ⟹   XP_063121185
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8862,818,688 - 62,829,040 (-)NCBI
RefSeq Acc Id: XR_005487761
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8862,755,519 - 62,828,984 (-)NCBI
mRatBN7.2853,859,324 - 53,932,773 (-)NCBI
1 to 5 of 11 rows
1 to 5 of 11 rows
RefSeq Acc Id: NP_001100291   ⟸   NM_001106821
- UniProtKB: D4ACL8 (UniProtKB/TrEMBL),   A6J4J4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008764444   ⟸   XM_008766222
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K3I0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000045529   ⟸   ENSRNOT00000050555
Ensembl Acc Id: ENSRNOP00000072646   ⟸   ENSRNOT00000086812
RefSeq Acc Id: XP_038936996   ⟸   XM_039081068
- Peptide Label: isoform X1
FAT   FATC   PI3K/PI4K catalytic


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 41 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-30436 BioCyc
Ensembl Genes ENSRNOG00000029773 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000050555 ENTREZGENE
  ENSRNOT00000050555.4 UniProtKB/TrEMBL
  ENSRNOT00000171802 ENTREZGENE
Gene3D-CATH 1.10.1070.11 UniProtKB/TrEMBL
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4 UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  ATM_plant UniProtKB/TrEMBL
  FATC UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  PI3/4_kinase_cat UniProtKB/TrEMBL
  PI3/4_kinase_cat_sf UniProtKB/TrEMBL
  PI3/4_kinase_CS UniProtKB/TrEMBL
  PIK-rel_kinase_FAT UniProtKB/TrEMBL
  PIK_FAT UniProtKB/TrEMBL
  PIKKc_ATM UniProtKB/TrEMBL
  TAN UniProtKB/TrEMBL
KEGG Report rno:300711 UniProtKB/TrEMBL
NCBI Gene 300711 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE ATM UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE ATM UniProtKB/TrEMBL
Pfam FAT UniProtKB/TrEMBL
  FATC UniProtKB/TrEMBL
  PI3_PI4_kinase UniProtKB/TrEMBL
  TAN UniProtKB/TrEMBL
PhenoGen Atm PhenoGen
PROSITE FAT UniProtKB/TrEMBL
  FATC UniProtKB/TrEMBL
  PI3_4_KINASE_1 UniProtKB/TrEMBL
  PI3_4_KINASE_2 UniProtKB/TrEMBL
  PI3_4_KINASE_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029773 RatGTEx
SMART FATC UniProtKB/TrEMBL
  PI3Kc UniProtKB/TrEMBL
  TAN UniProtKB/TrEMBL
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
UniProt A0A0G2K3I0 ENTREZGENE
  A6J4J4 ENTREZGENE, UniProtKB/TrEMBL
1 to 40 of 41 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-06-25 Atm  ATM serine/threonine kinase  Atm  ataxia telangiectasia mutated  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-01-14 Atm  ataxia telangiectasia mutated  Atm  ataxia telangiectasia mutated homolog (human)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-12   ataxia telangiectasia mutated homolog (human)  Atm  ataxia telangiectasia mutated homolog (human) (mapped)  Name updated 737654 APPROVED
2007-04-10 Atm  ataxia telangiectasia mutated homolog (human) (mapped)  Atm_mapped  ataxia telangiectasia mutated homolog (human) (mapped)  Data merged from RGD:2166 737654 APPROVED
2006-11-20 Atm  ataxia telangiectasia mutated homolog (human) (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Atm_mapped  ataxia telangiectasia mutated homolog (human) (mapped)  Atm  ataxia telangiectasia mutated homolog (human)  Symbol and Name updated 1556543 APPROVED
2002-11-06 Atm  ataxia telangiectasia mutated homolog (human)    Ataxia telangiectasia gene mutated in human beings  Name updated 625702 APPROVED
2002-06-10 Atm  Ataxia telangiectasia gene mutated in human beings      Symbol and Name status set to approved 70586 APPROVED