Tnfaip3 (TNF alpha induced protein 3) - Rat Genome Database

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Gene: Tnfaip3 (TNF alpha induced protein 3) Rattus norvegicus
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Symbol: Tnfaip3
Name: TNF alpha induced protein 3
RGD ID: 1589275
Description: Predicted to enable several functions, including K63-linked polyubiquitin modification-dependent protein binding activity; deubiquitinase activity; and enzyme binding activity. Predicted to be involved in several processes, including negative regulation of macromolecule metabolic process; negative regulation of signal transduction; and protein modification by small protein conjugation or removal. Predicted to act upstream of or within several processes, including negative regulation of interleukin-1 beta production; positive regulation of protein catabolic process; and protein K63-linked deubiquitination. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in breast cancer; colorectal cancer; esophageal cancer; and familial Behcet-like autoinflammatory syndrome. Orthologous to human TNFAIP3 (TNF alpha induced protein 3); PARTICIPATES IN nuclear factor kappa B signaling pathway; tumor necrosis factor mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC683206; similar to Tumor necrosis factor, alpha-induced protein 3 (Putative DNA binding protein A20) (Zinc finger protein A20); tumor necrosis factor alpha-induced protein 3; tumor necrosis factor, alpha-induced protein 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8115,528,921 - 15,543,993 (-)NCBIGRCr8
mRatBN7.2113,709,211 - 13,724,291 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl113,709,206 - 13,725,282 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0114,401,103 - 14,416,369 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl114,402,913 - 14,412,807 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0115,952,235 - 15,963,951 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera112,159,804 - 12,174,919 (-)NCBICelera
Cytogenetic Map1p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Tnfaip3Ratbreast cancer amelioratesISOTNFAIP3 (Homo sapiens)151347436associated with Neoplasm Metastasis and human cells in mouse modelRGD 
Tnfaip3Ratcholangiocarcinoma severityISOTNFAIP3 (Homo sapiens)11250478protein:increased expression:bile duct (human)RGD 
Tnfaip3RatChronic Hepatitis B susceptibilityISOTNFAIP3 (Homo sapiens)151347613DNA:SNP more ...RGD 
Tnfaip3Ratcolon cancer  ISOTNFAIP3 (Homo sapiens)151347624mRNA and protein:increased expression:colon (human)RGD 
Tnfaip3Ratcolon cancer  ISOTNFAIP3 (Homo sapiens)151347529protein:decreased expression:colon (human)RGD 
Tnfaip3Ratcolon cancer treatmentISOTnfaip3 (Mus musculus)151347529associated with Experimental ColitisRGD 
Tnfaip3Ratcolorectal cancer severityISOTNFAIP3 (Homo sapiens)151347611DNA:SNP:3'utr: (rs6920220) (human)RGD 
Tnfaip3RatCOVID-19  ISOTNFAIP3 (Homo sapiens)9068941mRNA:increased expression:CD14++ monocytes (human)RGDPMID:32377375 and REF_RGD_ID:32716422
Tnfaip3Ratesophageal cancer disease_progressionISOTNFAIP3 (Homo sapiens)151347597DNA:SNP:intron 6: (rs610604) (human)RGD 
Tnfaip3Ratesophageal cancer severityISOTNFAIP3 (Homo sapiens)11075880DNA:SNP:3'utr: (rs583522) (human)RGD 
Tnfaip3Ratesophagus squamous cell carcinoma severityISOTNFAIP3 (Homo sapiens)151347617mRNA and protein:increased expression:esophagus squamous epithelium (human)RGD 
Tnfaip3Rathepatocellular carcinoma sexual_dimorphismISOTnfaip3 (Mus musculus)151347600 RGD 
Tnfaip3Rathepatocellular carcinoma  ISOTNFAIP3 (Homo sapiens)151347622mRNA:decreased expression:liver (human)RGD 
Tnfaip3Rathepatocellular carcinoma  ISOTNFAIP3 (Homo sapiens)151347604protein:decreased expression:liver (human)RGD 
Tnfaip3Rathepatocellular carcinoma amelioratesISOTNFAIP3 (Homo sapiens)151347618mRNA and protein:increased expression:liver (human)RGD 
Tnfaip3Ratmetabolic dysfunction-associated steatotic liver disease severityISOTnfaip3 (Mus musculus)151347600 RGD 
Tnfaip3Ratnasopharynx carcinoma treatmentISOTNFAIP3 (Homo sapiens)151347434 RGD 
Tnfaip3Ratstomach carcinoma  ISOTNFAIP3 (Homo sapiens)151347607mRNA and protein:increased expression:stomach (human)RGD 
Tnfaip3Ratulcerative colitis severityISOTNFAIP3 (Homo sapiens)151347619mRNA more ...RGD 
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Tnfaip3RatFamilial Behcet-Like Autoinflammatory Syndrome  ISOTNFAIP3 (Homo sapiens)8554872ClinVar Annotator: match by term: Autoinflammatory syndrome more ...ClinVarPMID:24728327 more ...
Tnfaip3Ratfamilial Behcet-like autoinflammatory syndrome 1  ISOTNFAIP3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:24728327 more ...
Tnfaip3Ratgenetic disease  ISOTNFAIP3 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
Tnfaip3RatNontuberculous Mycobacterium Infections  ISOTNFAIP3 (Homo sapiens)8554872ClinVar Annotator: match by term: Disseminated atypical mycobacterial infectionClinVarPMID:26642243 more ...
Tnfaip3RatPeroxisome biogenesis disorder 9B  ISOTNFAIP3 (Homo sapiens)8554872ClinVar Annotator: match by term: Peroxisome biogenesis disorder 9BClinVarPMID:12325024 more ...
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Tnfaip3Ratautoimmune disease  ISOTNFAIP3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24453940
Tnfaip3Ratfollicular lymphoma  ISOTNFAIP3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24362818
Tnfaip3RatHereditary Autoinflammatory Diseases  ISOTNFAIP3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26642243
Tnfaip3RatInflammation  ISOTNFAIP3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24453940
Tnfaip3Ratmultiple sclerosis  ISOTNFAIP3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24076602
Tnfaip3RatNeoplastic Cell Transformation  ISOTNFAIP3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24362818
Tnfaip3Ratprimary cutaneous T-cell non-Hodgkin lymphoma  ISOTNFAIP3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26192916
Tnfaip3Ratpsoriasis  ISOTNFAIP3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19169254 and PMID:20953190
Tnfaip3Ratrheumatoid arthritis  ISOTNFAIP3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18794853 more ...
Tnfaip3RatSjogren's syndrome  ISOTNFAIP3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24097066 and PMID:24097067
Tnfaip3Ratsystemic lupus erythematosus  ISOTNFAIP3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19165918 more ...
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Tnfaip3Ratfamilial Behcet-like autoinflammatory syndrome 1  ISOTNFAIP3 (Homo sapiens)7240710 OMIM 

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Tnfaip3Rat(-)-demecolcine increases expressionISOTNFAIP3 (Homo sapiens)6480464Demecolcine results in increased expression of TNFAIP3 mRNACTDPMID:23649840
Tnfaip3Rat(S)-amphetamine decreases expressionISOTnfaip3 (Mus musculus)6480464Dextroamphetamine results in decreased expression of TNFAIP3 mRNACTDPMID:12205029
Tnfaip3Rat(S)-amphetamine multiple interactionsISOTnfaip3 (Mus musculus)6480464SOD1 inhibits the reaction [Dextroamphetamine results in decreased expression of TNFAIP3 mRNA]CTDPMID:12205029
Tnfaip3Rat1,1-dichloroethene increases expressionISOTnfaip3 (Mus musculus)6480464vinylidene chloride results in increased expression of TNFAIP3 mRNACTDPMID:26682919
Tnfaip3Rat1,2-dimethylhydrazine decreases expressionISOTnfaip3 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of TNFAIP3 mRNACTDPMID:22206623
Tnfaip3Rat1,4-phenylenediamine increases expressionISOTNFAIP3 (Homo sapiens)64804644-phenylenediamine results in increased expression of TNFAIP3 mRNACTDPMID:20713136
Tnfaip3Rat1-chloro-2,4-dinitrobenzene increases expressionISOTNFAIP3 (Homo sapiens)6480464Dinitrochlorobenzene results in increased expression of TNFAIP3 mRNACTDPMID:20146380
Tnfaip3Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of TNFAIP3 mRNACTDPMID:30723492
Tnfaip3Rat17beta-estradiol increases expressionISOTNFAIP3 (Homo sapiens)6480464Estradiol results in increased expression of TNFAIP3 mRNACTDPMID:19153601 more ...
Tnfaip3Rat17beta-estradiol decreases expressionISOTnfaip3 (Mus musculus)6480464Estradiol results in decreased expression of TNFAIP3 mRNACTDPMID:22467019
Tnfaip3Rat17beta-hydroxy-5alpha-androstan-3-one increases expressionISOTNFAIP3 (Homo sapiens)6480464Dihydrotestosterone results in increased expression of TNFAIP3 mRNACTDPMID:29581250
Tnfaip3Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOTNFAIP3 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of TNFAIP3 mRNACTDPMID:16704738
Tnfaip3Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of TNFAIP3 mRNACTDPMID:33387578
Tnfaip3Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOTnfaip3 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of TNFAIP3 mRNACTDPMID:32553695
Tnfaip3Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOTnfaip3 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of TNFAIP3 mRNACTDPMID:21570461
Tnfaip3Rat2,3-dimethoxynaphthalene-1,4-dione increases expressionISOTNFAIP3 (Homo sapiens)64804642 more ...CTDPMID:17547211
Tnfaip3Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOTnfaip3 (Mus musculus)64804642 more ...CTDPMID:38648751
Tnfaip3Rat2-butoxyethanol decreases expressionISOTnfaip3 (Mus musculus)6480464n-butoxyethanol results in decreased expression of TNFAIP3 mRNACTDPMID:19812364
Tnfaip3Rat2-butoxyethanol increases expressionISOTnfaip3 (Mus musculus)6480464n-butoxyethanol results in increased expression of TNFAIP3 mRNACTDPMID:19812364
Tnfaip3Rat2-hydroxypropanoic acid increases expressionISOTNFAIP3 (Homo sapiens)6480464Lactic Acid results in increased expression of TNFAIP3 mRNACTDPMID:30851411

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Biological Process
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Tnfaip3RatB-1 B cell homeostasis involved_inISOTnfaip3 (Mus musculus)1624291 PMID:21088135RGDPMID:21088135
Tnfaip3Ratcell migration involved_inIBAPANTHER:PTN000332188 and UniProtKB:Q9UGI01600115GO_REF:0000033GO_CentralGO_REF:0000033
Tnfaip3Ratcellular response to hydrogen peroxide involved_inISOTnfaip3 (Mus musculus)1624291 PMID:23609450RGDPMID:23609450
Tnfaip3Ratcellular response to lipopolysaccharide involved_inISOTNFAIP3 (Homo sapiens)1624291 PMID:19912257 more ...RGDPMID:19912257 more ...
Tnfaip3Ratcytoskeleton organization involved_inIBAPANTHER:PTN000332188 and UniProtKB:Q9UGI01600115GO_REF:0000033GO_CentralGO_REF:0000033
Tnfaip3Ratestablishment of protein localization to vacuole acts_upstream_of_or_withinISOTnfaip3 (Mus musculus)1624291 PMID:18952128RGDPMID:18952128
Tnfaip3Ratnegative regulation of B cell activation involved_inISOTnfaip3 (Mus musculus)1624291 PMID:21088135RGDPMID:21088135
Tnfaip3Ratnegative regulation of canonical NF-kappaB signal transduction involved_inISOTnfaip3 (Mus musculus)1624291 PMID:18342009 and PMID:21088135RGDPMID:18342009 and PMID:21088135
Tnfaip3Ratnegative regulation of canonical NF-kappaB signal transduction involved_inISOTNFAIP3 (Homo sapiens)1624291 PMID:11463333 more ...RGDPMID:11463333 more ...
Tnfaip3Ratnegative regulation of CD40 signaling pathway involved_inISOTNFAIP3 (Homo sapiens)1624291 PMID:12885753RGDPMID:12885753
Tnfaip3Ratnegative regulation of chronic inflammatory response involved_inISOTnfaip3 (Mus musculus)1624291 PMID:18006655RGDPMID:18006655
Tnfaip3Ratnegative regulation of cyclin-dependent protein serine/threonine kinase activity involved_inISOTnfaip3 (Mus musculus)1624291 PMID:15962316RGDPMID:15962316
Tnfaip3Ratnegative regulation of endothelial cell apoptotic process involved_inISOTNFAIP3 (Homo sapiens)1624291 PMID:12885753RGDPMID:12885753
Tnfaip3Ratnegative regulation of extrinsic apoptotic signaling pathway involved_inISOTnfaip3 (Mus musculus)1624291 PMID:11009421RGDPMID:11009421
Tnfaip3Ratnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors involved_inISOTNFAIP3 (Homo sapiens)1624291 PMID:12167698RGDPMID:12167698
Tnfaip3Ratnegative regulation of inflammatory response involved_inISOTnfaip3 (Mus musculus)1624291 PMID:21088135 and PMID:23609450RGDPMID:21088135 and PMID:23609450
Tnfaip3Ratnegative regulation of innate immune response involved_inISOTnfaip3 (Mus musculus)1624291 PMID:23609450RGDPMID:23609450
Tnfaip3Ratnegative regulation of interleukin-1 beta production acts_upstream_of_or_withinISOTNFAIP3 (Homo sapiens)1624291 PMID:28094437RGDPMID:28094437
Tnfaip3Ratnegative regulation of interleukin-1 beta production involved_inISOTnfaip3 (Mus musculus)1624291 PMID:18006655 and PMID:18342009RGDPMID:18006655 and PMID:18342009
Tnfaip3Ratnegative regulation of interleukin-2 production involved_inISOTNFAIP3 (Homo sapiens)1624291 PMID:18223652RGDPMID:18223652
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Cellular Component

  
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Tnfaip3Ratcytoplasm located_inISOTnfaip3 (Mus musculus)1624291 PMID:10385526RGDPMID:10385526
Tnfaip3Ratcytoplasm is_active_inIBAMGI:1196377 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tnfaip3Ratnucleus located_inISOTNFAIP3 (Homo sapiens)1624291 PMID:11463333RGDPMID:11463333
Tnfaip3Ratnucleus is_active_inIBAPANTHER:PTN001001090 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function
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Tnfaip3Ratcysteine-type deubiquitinase activity enablesISOTNFAIP3 (Homo sapiens)1624291 PMID:15258597 and PMID:23827681RGDPMID:15258597 and PMID:23827681
Tnfaip3Ratcysteine-type deubiquitinase activity enablesIBAMGI:2654703 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tnfaip3RatDNA binding enablesIEAInterPro:IPR0026531600115GO_REF:0000002InterProGO_REF:0000002
Tnfaip3Ratidentical protein binding enablesISOTNFAIP3 (Homo sapiens)1624291UniProtKB:P21580 more ...RGDPMID:25416956 more ...
Tnfaip3RatK63-linked deubiquitinase activity enablesISOTNFAIP3 (Homo sapiens)1624291 PMID:14748687RGDPMID:14748687
Tnfaip3RatK63-linked polyubiquitin modification-dependent protein binding enablesIBAMGI:2654703 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tnfaip3Ratkinase binding enablesISOTnfaip3 (Mus musculus)1624291 PMID:18342009RGDPMID:18342009
Tnfaip3Ratprotease binding enablesISOTNFAIP3 (Homo sapiens)1624291UniProtKB:Q9UDY8 and PMID:18223652RGDPMID:18223652
Tnfaip3Ratprotein binding enablesISOTnfaip3 (Mus musculus)1624291PR:Q99JG7 more ...RGDPMID:10385526 more ...
Tnfaip3Ratprotein binding enablesISOTNFAIP3 (Homo sapiens)1624291UniProtKB:O95995 more ...RGDPMID:11463333 more ...
Tnfaip3Ratubiquitin binding enablesISOTNFAIP3 (Homo sapiens)1624291UniProtKB:P0CG48 and PMID:19285159RGDPMID:19285159
Tnfaip3Ratubiquitin-protein transferase activity enablesISOTNFAIP3 (Homo sapiens)1624291 PMID:15258597RGDPMID:15258597
Tnfaip3Ratzinc ion binding enablesIEAUniProtKB-KW:KW-08631600115GO_REF:0000043UniProtGO_REF:0000043
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RGD Manual Annotations


  

Imported Annotations - PID (archival)

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Original Reference(s)
Tnfaip3Ratnuclear factor kappa B signaling pathway   ISOTNFAIP3 (Homo sapiens)9068941 PIDPID:200031

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#
Reference Title
Reference Citation
1. A20 prevents chronic liver inflammation and cancer by protecting hepatocytes from death. Catrysse L, etal., Cell Death Dis. 2016 Jun 2;7(6):e2250. doi: 10.1038/cddis.2016.154.
2. A20 suppresses hepatocellular carcinoma proliferation and metastasis through inhibition of Twist1 expression. Chen H, etal., Mol Cancer. 2015 Nov 4;14:186. doi: 10.1186/s12943-015-0454-6.
3. Regulation of NF-kappaB by ubiquitination. Chen J and Chen ZJ, Curr Opin Immunol. 2013 Feb;25(1):4-12. doi: 10.1016/j.coi.2012.12.005. Epub 2013 Jan 8.
4. Expressions of Tumor Necrosis Factor alpha-induced Protein 3 and Mammary Serine Protease Inhibitor in Radiotherapy of Nasopharyngeal Carcinoma. Deng XQ, etal., Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2015 Jun;37(3):279-84. doi: 10.3881/j.issn.1000-503X.2015.03.006.
5. The potential role of TNFAIP3 in malignant transformation of gastric carcinoma. Du B, etal., Pathol Res Pract. 2019 Aug;215(8):152471. doi: 10.1016/j.prp.2019.152471. Epub 2019 May 24.
6. A20 targets PFKL and glycolysis to inhibit the progression of hepatocellular carcinoma. Feng Y, etal., Cell Death Dis. 2020 Feb 3;11(2):89. doi: 10.1038/s41419-020-2278-6.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Evaluation of the germline single nucleotide polymorphism rs583522 in the TNFAIP3 gene as a prognostic marker in esophageal cancer. Ghadban T, etal., Cancer Genet. 2015 Dec;208(12):595-601. doi: 10.1016/j.cancergen.2015.09.008. Epub 2015 Oct 9.
9. An A/C germline single-nucleotide polymorphism in the TNFAIP3 gene is associated with advanced disease stage and survival in only surgically treated esophageal cancer. Ghadban T, etal., J Hum Genet. 2014 Dec;59(12):661-6. doi: 10.1038/jhg.2014.90. Epub 2014 Oct 30.
10. TNFAIP3 overexpression is an independent factor for poor survival in esophageal squamous cell carcinoma. Hadisaputri YE, etal., Int J Oncol. 2017 Mar;50(3):1002-1010. doi: 10.3892/ijo.2017.3869. Epub 2017 Feb 9.
11. Deubiquitinases in the regulation of NF-kappaB signaling. Harhaj EW and Dixit VM, Cell Res. 2011 Jan;21(1):22-39. doi: 10.1038/cr.2010.166. Epub 2010 Nov 30.
12. A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1. Lee JH, etal., Nat Cell Biol. 2017 Oct;19(10):1260-1273. doi: 10.1038/ncb3609. Epub 2017 Sep 11.
13. Association of the tandem polymorphisms (rs148314165, rs200820567) in TNFAIP3 with chronic hepatitis B virus infection in Chinese Han population. Li N, etal., Virol J. 2017 Aug 7;14(1):148. doi: 10.1186/s12985-017-0814-5.
14. Ubiquitin ligase A20 regulates p53 protein in human colon epithelial cells. Liu J, etal., J Biomed Sci. 2013 Oct 7;20:74. doi: 10.1186/1423-0127-20-74.
15. A20 enhances the radiosensitivity of hepatocellular carcinoma cells to 60Co-γ ionizing radiation. Liu R, etal., Oncotarget. 2017 Oct 16;8(54):93103-93116. doi: 10.18632/oncotarget.21860. eCollection 2017 Nov 3.
16. Altered expression of Tumor Necrosis Factor Alpha -Induced Protein 3 correlates with disease severity in Ulcerative Colitis. Majumdar I, etal., Sci Rep. 2017 Aug 25;7(1):9420. doi: 10.1038/s41598-017-09796-9.
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Genetic variation and alterations of genes involved in NFκB/TNFAIP3- and NLRP3-inflammasome signaling affect susceptibility and outcome of colorectal cancer. Ungerbäck J, etal., Carcinogenesis. 2012 Nov;33(11):2126-34. doi: 10.1093/carcin/bgs256. Epub 2012 Jul 28.
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PMID:8797804   PMID:10385526   PMID:11009421   PMID:11389905   PMID:11463333   PMID:12167698   PMID:12885753   PMID:14748687   PMID:15258597   PMID:15474016   PMID:15962316   PMID:16816117  
PMID:18006655   PMID:18223652   PMID:18342009   PMID:18952128   PMID:19285159   PMID:19912257   PMID:20392859   PMID:20430393   PMID:20458337   PMID:21088135   PMID:21127049   PMID:21220427  
PMID:21923101   PMID:23609450   PMID:23827681   PMID:24012418   PMID:25416956   PMID:25502805   PMID:26231971   PMID:26991692   PMID:28094437   PMID:30561431   PMID:31515488   PMID:34481142  
PMID:37995648  



Tnfaip3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8115,528,921 - 15,543,993 (-)NCBIGRCr8
mRatBN7.2113,709,211 - 13,724,291 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl113,709,206 - 13,725,282 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0114,401,103 - 14,416,369 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl114,402,913 - 14,412,807 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0115,952,235 - 15,963,951 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera112,159,804 - 12,174,919 (-)NCBICelera
Cytogenetic Map1p12NCBI
TNFAIP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386137,866,349 - 137,883,312 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6137,867,214 - 137,883,314 (+)EnsemblGRCh38hg38GRCh38
GRCh376138,188,396 - 138,204,449 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366138,230,274 - 138,246,142 (+)NCBINCBI36Build 36hg18NCBI36
Build 346138,230,273 - 138,246,141NCBI
Celera6138,928,721 - 138,944,581 (+)NCBICelera
Cytogenetic Map6q23.3NCBI
HuRef6135,750,495 - 135,766,617 (+)NCBIHuRef
CHM1_16138,450,716 - 138,466,833 (+)NCBICHM1_1
T2T-CHM13v2.06139,054,729 - 139,071,725 (+)NCBIT2T-CHM13v2.0
Tnfaip3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391018,876,658 - 18,891,158 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1018,876,658 - 18,891,405 (-)EnsemblGRCm39 Ensembl
GRCm381019,000,910 - 19,015,410 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1019,000,910 - 19,015,657 (-)EnsemblGRCm38mm10GRCm38
MGSCv371018,720,716 - 18,735,216 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361018,690,332 - 18,704,783 (-)NCBIMGSCv36mm8
Celera1018,907,568 - 18,922,063 (-)NCBICelera
Cytogenetic Map10A3NCBI
cM Map108.08NCBI
Tnfaip3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543621,566,423 - 21,578,469 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543621,566,591 - 21,581,551 (-)NCBIChiLan1.0ChiLan1.0
TNFAIP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25157,824,380 - 157,840,522 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16155,721,970 - 155,737,920 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06135,617,465 - 135,634,085 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16139,705,255 - 139,721,264 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6139,705,255 - 139,720,819 (+)Ensemblpanpan1.1panPan2
TNFAIP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1130,247,432 - 30,262,992 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl130,251,059 - 30,261,001 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha131,130,692 - 31,146,131 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0130,415,149 - 30,430,593 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl130,415,167 - 30,428,600 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1130,293,899 - 30,309,336 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0130,175,668 - 30,191,127 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0130,484,573 - 30,499,998 (+)NCBIUU_Cfam_GSD_1.0
Tnfaip3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946125,345,739 - 125,359,816 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365605,128,843 - 5,138,345 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365605,124,955 - 5,138,988 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNFAIP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl126,473,938 - 26,489,822 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1126,474,158 - 26,489,771 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2129,825,892 - 29,841,634 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TNFAIP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11335,537,103 - 35,553,396 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1335,537,102 - 35,549,197 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660407,722,304 - 7,738,445 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

.

Predicted Target Of
Summary Value
Count of predictions:75
Count of miRNA genes:72
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000074583
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 17 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1529322934184556Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1774611852746118Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1774612152746121Rat
70179Xhs2X-ray hypersensitivity QTL 23.2intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)1143965634Rat
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1126564886Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)11037949255379492Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1694102251941022Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1529322934184556Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)1690935351909353Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1126564886Rat

1 to 10 of 17 rows
D1Rat250  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2113,717,158 - 13,717,273 (+)MAPPERmRatBN7.2
Rnor_6.0114,409,169 - 14,409,285NCBIRnor6.0
Rnor_5.0115,960,301 - 15,960,417UniSTSRnor5.0
Celera112,167,753 - 12,167,867UniSTS
RH 3.4 Map1143.6UniSTS
RH 3.4 Map1143.6RGD
RH 2.0 Map157.6RGD
SHRSP x BN Map110.34RGD




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 16 of 16 rows
RefSeq Transcripts NM_001427106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_001060914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_003748656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006222835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006222836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005497282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 16 of 16 rows

Ensembl Acc Id: ENSRNOT00000074583   ⟹   ENSRNOP00000065542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl113,709,206 - 13,725,282 (-)Ensembl
Rnor_6.0 Ensembl114,402,913 - 14,412,807 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095738   ⟹   ENSRNOP00000093412
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl113,709,206 - 13,723,498 (-)Ensembl
RefSeq Acc Id: NM_001427106   ⟹   NP_001414035
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8115,528,921 - 15,543,979 (-)NCBI
RefSeq Acc Id: XM_039098825   ⟹   XP_038954753
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8115,528,921 - 15,542,630 (-)NCBI
mRatBN7.2113,709,211 - 13,722,918 (-)NCBI
RefSeq Acc Id: XM_039098833   ⟹   XP_038954761
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8115,528,921 - 15,543,211 (-)NCBI
mRatBN7.2113,709,211 - 13,723,500 (-)NCBI
RefSeq Acc Id: XM_039098843   ⟹   XP_038954771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8115,528,921 - 15,543,993 (-)NCBI
mRatBN7.2113,709,211 - 13,724,290 (-)NCBI
RefSeq Acc Id: XR_005497282
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8115,528,921 - 15,542,630 (-)NCBI
mRatBN7.2113,709,211 - 13,722,918 (-)NCBI
Protein RefSeqs NP_001414035 (Get FASTA)   NCBI Sequence Viewer  
  XP_038954753 (Get FASTA)   NCBI Sequence Viewer  
  XP_038954761 (Get FASTA)   NCBI Sequence Viewer  
  XP_038954771 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93780 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000065542.2
  ENSRNOP00000093412.1
Ensembl Acc Id: ENSRNOP00000065542   ⟸   ENSRNOT00000074583
RefSeq Acc Id: XP_038954771   ⟸   XM_039098843
- Peptide Label: isoform X2
- UniProtKB: M0R7V5 (UniProtKB/TrEMBL),   A6JPA8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038954761   ⟸   XM_039098833
- Peptide Label: isoform X2
- UniProtKB: M0R7V5 (UniProtKB/TrEMBL),   A6JPA8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038954753   ⟸   XM_039098825
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AL23 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000093412   ⟸   ENSRNOT00000095738
A20-type   OTU

Name Modeler Protein Id AA Range Protein Structure
AF-M0R7V5-F1-model_v2 AlphaFold M0R7V5 1-814 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13689519
Promoter ID:EPDNEW_R34
Type:single initiation site
Name:Tnfaip3_1
Description:TNF alpha induced protein 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0114,412,891 - 14,412,951EPDNEW


1 to 23 of 23 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-62250 BioCyc
Ensembl Genes ENSRNOG00000049517 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000074583.2 UniProtKB/TrEMBL
  ENSRNOT00000095738.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.4770 UniProtKB/TrEMBL
  3.90.70.80 UniProtKB/TrEMBL
  4.10.240.30 UniProtKB/TrEMBL
InterPro OTU UniProtKB/TrEMBL
  OTU_Deubiquitinase UniProtKB/TrEMBL
  Znf_A20 UniProtKB/TrEMBL
NCBI Gene 683206 ENTREZGENE
PANTHER PTHR13367:SF3 UniProtKB/TrEMBL
  UBIQUITIN THIOESTERASE UniProtKB/TrEMBL
Pfam OTU UniProtKB/TrEMBL
  zf-A20 UniProtKB/TrEMBL
PhenoGen Tnfaip3 PhenoGen
PROSITE OTU UniProtKB/TrEMBL
  ZF_A20 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000049517 RatGTEx
SMART ZnF_A20 UniProtKB/TrEMBL
UniProt A0A8I6AL23 ENTREZGENE, UniProtKB/TrEMBL
  A6JPA8 ENTREZGENE, UniProtKB/TrEMBL
  M0R7V5 ENTREZGENE, UniProtKB/TrEMBL
1 to 23 of 23 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Tnfaip3  TNF alpha induced protein 3  Tnfaip3  tumor necrosis factor, alpha-induced protein 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-13 Tnfaip3  tumor necrosis factor, alpha-induced protein 3  LOC683206  similar to Tumor necrosis factor, alpha-induced protein 3 (Putative DNA binding protein A20) (Zinc finger protein A20)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC683206  similar to Tumor necrosis factor, alpha-induced protein 3 (Putative DNA binding protein A20) (Zinc finger protein A20)      Symbol and Name status set to provisional 70820 PROVISIONAL