Brcc3 (BRCA1/BRCA2-containing complex subunit 3) - Rat Genome Database

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Gene: Brcc3 (BRCA1/BRCA2-containing complex subunit 3) Rattus norvegicus
Analyze
Symbol: Brcc3
Name: BRCA1/BRCA2-containing complex subunit 3
RGD ID: 1588543
Description: Predicted to enable deubiquitinase activity; enzyme regulator activity; and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in several processes, including DNA repair-dependent chromatin remodeling; mitotic G2 DNA damage checkpoint signaling; and positive regulation of NLRP3 inflammasome complex assembly. Predicted to act upstream of or within response to X-ray. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of BRCA1-A complex; BRISC complex; and nuclear ubiquitin ligase complex. Orthologous to human BRCC3 (BRCA1/BRCA2-containing complex subunit 3); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BRCA1-A complex subunit BRCC36; BRCA1/BRCA2-containing complex subunit 36; BRCA1/BRCA2-containing complex, subunit 3; BRCA1/BRCA2-containing complex, subunit 3 like 1; Brcc3l1; BRISC complex subunit BRCC36; LOC316794; lys-63-specific deubiquitinase BRCC36; similar to BRCA1/BRCA2-containing complex subunit 36 isoform 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Brcc3-ps7  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr892,073,927 - 2,076,469 (+)NCBIGRCr8
mRatBN7.291,986,942 - 1,989,484 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,986,575 - 1,991,080 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx92,421,214 - 2,423,760 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,770,588 - 7,773,134 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,726,439 - 6,728,985 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.099,863,380 - 9,865,920 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl99,863,404 - 9,865,920 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.098,864,902 - 8,867,442 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera96,530,917 - 6,533,459 (-)NCBICelera
Cytogenetic Map9q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Brcc3RatOccupational Diseases  ISOBRCC3 (Homo sapiens)9586067 RGD 
Brcc3RatPregnancy in Diabetics  ISOBrcc3 (Mus musculus)9586066mRNA:increased expression:embryo:RGD 
1 to 15 of 15 rows
Object Symbol
Species
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Reference
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Original Reference(s)
Brcc3Ratadrenoleukodystrophy  ISOBRCC3 (Homo sapiens)8554872ClinVar Annotator: match by term: AdrenoleukodystrophyClinVarPMID:10480214 more ...
Brcc3Ratautistic disorder  ISOBRCC3 (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311
Brcc3Ratautosomal hemophilia A  ISOBRCC3 (Homo sapiens)8554872ClinVar Annotator: match by term: AUTOSOMAL HEMOPHILIA AClinVarPMID:31690835
Brcc3RatBarth syndrome  ISOBRCC3 (Homo sapiens)8554872ClinVar Annotator: match by term: 3-Methylglutaconic aciduria type 2ClinVarPMID:10480214 more ...
Brcc3Ratcerebral creatine deficiency syndrome 1  ISOBRCC3 (Homo sapiens)8554872ClinVar Annotator: match by term: Creatine transporter deficiencyClinVarPMID:10480214 more ...
Brcc3Ratdyskeratosis congenita  ISOBRCC3 (Homo sapiens)8554872ClinVar Annotator: match by term: Dyskeratosis congenitaClinVarPMID:18177777 and PMID:28492532
Brcc3RatEmery-Dreifuss muscular dystrophy  ISOBRCC3 (Homo sapiens)8554872ClinVar Annotator: match by term: X-linked Emery-Dreifuss muscular dystrophyClinVarPMID:10480214 more ...
Brcc3Ratfactor VIII deficiency  ISOBRCC3 (Homo sapiens)8554872ClinVar Annotator: match by term: Factor 8 deficiency and congenitalClinVarPMID:31690835
Brcc3Ratfavism  ISOBRCC3 (Homo sapiens)8554872ClinVar Annotator: match by term: Anemia more ...ClinVarPMID:18177777 and PMID:28492532
Brcc3RatHereditary Neoplastic Syndromes  ISOBRCC3 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary cancer-predisposing syndromeClinVar 
Brcc3RatHereditary Neoplastic Syndromes  ISOBRCC3 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary cancer-predisposing syndromeClinVarPMID:25741868
Brcc3Ratimmunodeficiency 33  ISOBRCC3 (Homo sapiens)8554872ClinVar Annotator: match by term: Immunodeficiency 33ClinVarPMID:25741868
Brcc3Ratparaplegia  ISOBRCC3 (Homo sapiens)8554872ClinVar Annotator: match by term: Spastic paraplegiaClinVarPMID:10480214 more ...
Brcc3Ratperiventricular nodular heterotopia  ISOBRCC3 (Homo sapiens)8554872ClinVar Annotator: match by term: Heterotopia more ...ClinVarPMID:10480214 more ...
Brcc3RatSplenomegaly  ISOBRCC3 (Homo sapiens)8554872ClinVar Annotator: match by term: SplenomegalyClinVarPMID:25741868
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1 to 20 of 76 rows

  
Object Symbol
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Original Reference(s)
Brcc3Rat(+)-catechin decreases expressionISOBRCC3 (Homo sapiens)6480464Catechin results in decreased expression of BRCC3 mRNACTDPMID:15465739
Brcc3Rat1,2-dimethylhydrazine multiple interactionsISOBrcc3 (Mus musculus)6480464Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of BRCC3 mRNA]CTDPMID:22206623
Brcc3Rat1,2-dimethylhydrazine decreases expressionISOBrcc3 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of BRCC3 mRNACTDPMID:22206623
Brcc3Rat17alpha-ethynylestradiol affects expressionISOBrcc3 (Mus musculus)6480464Ethinyl Estradiol affects the expression of BRCC3 mRNACTDPMID:17555576
Brcc3Rat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISOBRCC3 (Homo sapiens)64804642 more ...CTDPMID:31675489
Brcc3Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOBrcc3 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of BRCC3 mRNACTDPMID:19465110
Brcc3Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of BRCC3 mRNACTDPMID:33387578
Brcc3Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOBrcc3 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of BRCC3 mRNACTDPMID:21570461
Brcc3Rat2,4,6-tribromophenol increases expressionISOBRCC3 (Homo sapiens)64804642 more ...CTDPMID:31675489
Brcc3Rat3,3',4,4'-tetrachlorobiphenyl multiple interactionsISOBrcc3 (Mus musculus)64804643 more ...CTDPMID:19467301
Brcc3Rat3,3',5,5'-tetrabromobisphenol A decreases expressionISOBRCC3 (Homo sapiens)6480464tetrabromobisphenol A results in decreased expression of BRCC3 proteinCTDPMID:31675489
Brcc3Rat3H-1,2-dithiole-3-thione decreases expressionEXP 64804641 and 2-dithiol-3-thione results in decreased expression of BRCC3 mRNACTDPMID:19162173
Brcc3Rat4,4'-sulfonyldiphenol increases expressionISOBrcc3 (Mus musculus)6480464bisphenol S results in increased expression of BRCC3 mRNACTDPMID:39298647
Brcc3Ratacetamide decreases expressionEXP 6480464acetamide results in decreased expression of BRCC3 mRNACTDPMID:31881176
Brcc3Rataflatoxin B1 increases expressionISOBrcc3 (Mus musculus)6480464Aflatoxin B1 results in increased expression of BRCC3 mRNACTDPMID:19770486
Brcc3Rataflatoxin B1 decreases methylationISOBRCC3 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of BRCC3 geneCTDPMID:27153756
Brcc3Ratamiodarone increases expressionISOBRCC3 (Homo sapiens)6480464Amiodarone results in increased expression of BRCC3 mRNACTDPMID:19774075
Brcc3Ratbenzo[a]pyrene decreases expressionISOBrcc3 (Mus musculus)6480464Benzo(a)pyrene results in decreased expression of BRCC3 mRNACTDPMID:19770486
Brcc3Ratbenzo[a]pyrene increases methylationISOBRCC3 (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of BRCC3 exonCTDPMID:27901495
Brcc3Ratbenzo[a]pyrene affects methylationISOBRCC3 (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of BRCC3 5' UTR and Benzo(a)pyrene affects the methylation of BRCC3 promoterCTDPMID:27901495

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Biological Process
1 to 20 of 28 rows

  
Object Symbol
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Reference
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Original Reference(s)
Brcc3Ratcell division involved_inIEAUniProtKB-KW:KW-01321600115GO_REF:0000043UniProtGO_REF:0000043
Brcc3Ratcellular response to ionizing radiation involved_inISOBRCC3 (Homo sapiens)1624291 PMID:14636569RGDPMID:14636569
Brcc3Ratchromatin organization involved_inIEAUniProtKB-KW:KW-01561600115GO_REF:0000043UniProtGO_REF:0000043
Brcc3Ratchromatin remodeling involved_inISSUniProtKB:P467371600115GO_REF:0000024UniProtGO_REF:0000024
Brcc3Ratchromatin remodeling involved_inISOBrcc3 (Mus musculus)1624291 PMID:34180153RGDPMID:34180153
Brcc3RatDNA damage response involved_inIEAUniProtKB-KW:KW-02271600115GO_REF:0000043UniProtGO_REF:0000043
Brcc3RatDNA repair involved_inIEAInterPro:IPR0338601600115GO_REF:0000002InterProGO_REF:0000002
Brcc3RatDNA repair involved_inIEAUniProtKB-KW:KW-02341600115GO_REF:0000043UniProtGO_REF:0000043
Brcc3RatDNA repair-dependent chromatin remodeling involved_inISOBRCC3 (Homo sapiens)1624291 PMID:19202061 and PMID:19261746RGDPMID:19202061 and PMID:19261746
Brcc3RatDNA repair-dependent chromatin remodeling involved_inISSUniProtKB:P467361600115GO_REF:0000024UniProtGO_REF:0000024
Brcc3Ratdouble-strand break repair involved_inISSUniProtKB:P467361600115GO_REF:0000024UniProtGO_REF:0000024
Brcc3Ratdouble-strand break repair involved_inIBAPANTHER:PTN000045567 and UniProtKB:P467361600115GO_REF:0000033GO_CentralGO_REF:0000033
Brcc3Ratdouble-strand break repair involved_inISOBRCC3 (Homo sapiens)1624291 PMID:17525341 more ...RGDPMID:17525341 more ...
Brcc3Ratmitotic G2 DNA damage checkpoint signaling involved_inISSUniProtKB:P467361600115GO_REF:0000024UniProtGO_REF:0000024
Brcc3Ratmitotic G2 DNA damage checkpoint signaling involved_inISOBRCC3 (Homo sapiens)1624291 PMID:17525341 more ...RGDPMID:17525341 more ...
Brcc3Ratpositive regulation of DNA repair involved_inISSUniProtKB:P467361600115GO_REF:0000024UniProtGO_REF:0000024
Brcc3Ratpositive regulation of DNA repair involved_inISOBRCC3 (Homo sapiens)1624291 PMID:17525341 more ...RGDPMID:17525341 more ...
Brcc3Ratpositive regulation of NLRP3 inflammasome complex assembly involved_inISSUniProtKB:P467371600115GO_REF:0000024UniProtGO_REF:0000024
Brcc3Ratpositive regulation of NLRP3 inflammasome complex assembly involved_inISOBrcc3 (Mus musculus)1624291 PMID:23246432RGDPMID:23246432
Brcc3Ratpositive regulation of NLRP3 inflammasome complex assembly involved_inISOBRCC3 (Homo sapiens)1624291 PMID:28943315RGDPMID:28943315
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Cellular Component
1 to 20 of 20 rows

  
Object Symbol
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Original Reference(s)
Brcc3RatBRCA1-A complex part_ofISOBRCC3 (Homo sapiens)1624291 PMID:17525341 more ...RGDPMID:17525341 more ...
Brcc3RatBRCA1-A complex part_ofIEAInterPro:IPR0338601600115GO_REF:0000002InterProGO_REF:0000002
Brcc3RatBRCA1-A complex part_ofIBAPANTHER:PTN000045567 and UniProtKB:P467361600115GO_REF:0000033GO_CentralGO_REF:0000033
Brcc3RatBRCA1-A complex part_ofISSUniProtKB:P467361600115GO_REF:0000024UniProtGO_REF:0000024
Brcc3RatBRISC complex part_ofISSUniProtKB:P467361600115GO_REF:0000024UniProtGO_REF:0000024
Brcc3RatBRISC complex part_ofIBAPANTHER:PTN000045567 and UniProtKB:P467361600115GO_REF:0000033GO_CentralGO_REF:0000033
Brcc3RatBRISC complex part_ofIEAInterPro:IPR0338601600115GO_REF:0000002InterProGO_REF:0000002
Brcc3RatBRISC complex part_ofISOBRCC3 (Homo sapiens)1624291 PMID:19214193 and PMID:24075985RGDPMID:19214193 and PMID:24075985
Brcc3Ratcytoplasm located_inISOBRCC3 (Homo sapiens)1624291 PMID:24075985RGDPMID:24075985
Brcc3Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Brcc3Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Brcc3Ratcytoskeleton located_inIEAUniProtKB-KW:KW-02061600115GO_REF:0000043UniProtGO_REF:0000043
Brcc3Ratnuclear ubiquitin ligase complex part_ofISOBRCC3 (Homo sapiens)1624291 PMID:14636569RGDPMID:14636569
Brcc3Ratnucleoplasm located_inISOBRCC3 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Brcc3Ratnucleus located_inISSUniProtKB:P467361600115GO_REF:0000024UniProtGO_REF:0000024
Brcc3Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Brcc3Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Brcc3Ratnucleus located_inISOBRCC3 (Homo sapiens)1624291 PMID:14636569 and PMID:19202061RGDPMID:14636569 and PMID:19202061
Brcc3Ratspindle pole located_inIEAUniProtKB-SubCell:SL-04481600115GO_REF:0000044UniProtGO_REF:0000044
Brcc3Ratubiquitin ligase complex part_ofISOBRCC3 (Homo sapiens)1624291 PMID:14636569RGDPMID:14636569
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Molecular Function
1 to 20 of 21 rows

  
Object Symbol
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Original Reference(s)
Brcc3Ratcysteine-type deubiquitinase activity enablesIEAInterPro:IPR0338601600115GO_REF:0000002InterProGO_REF:0000002
Brcc3Ratenzyme regulator activity enablesISOBRCC3 (Homo sapiens)1624291 PMID:14636569RGDPMID:14636569
Brcc3Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Brcc3RatK63-linked deubiquitinase activity enablesISOBRCC3 (Homo sapiens)1624291 PMID:19202061 and PMID:28943315RGDPMID:19202061 and PMID:28943315
Brcc3Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Brcc3Ratmetal-dependent deubiquitinase activity enablesISOBRCC3 (Homo sapiens)1624291 PMID:19261746RGDPMID:19261746
Brcc3Ratmetal-dependent deubiquitinase activity enablesISOBrcc3 (Mus musculus)1624291 PMID:23246432RGDPMID:23246432
Brcc3Ratmetal-dependent deubiquitinase activity enablesISSUniProtKB:P467371600115GO_REF:0000024UniProtGO_REF:0000024
Brcc3Ratmetal-dependent deubiquitinase activity enablesISSUniProtKB:P467361600115GO_REF:0000024UniProtGO_REF:0000024
Brcc3Ratmetallopeptidase activity enablesISSUniProtKB:P467361600115GO_REF:0000024UniProtGO_REF:0000024
Brcc3Ratmetallopeptidase activity enablesIEAInterPro:IPR0005551600115GO_REF:0000002InterProGO_REF:0000002
Brcc3Ratmetallopeptidase activity enablesIEAUniProtKB-KW:KW-04821600115GO_REF:0000043UniProtGO_REF:0000043
Brcc3Ratmetallopeptidase activity enablesIBAFB:FBgn0027053 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Brcc3Ratmetallopeptidase activity enablesISOBRCC3 (Homo sapiens)1624291 PMID:17525341 more ...RGDPMID:17525341 more ...
Brcc3Ratpeptidase activity enablesIEAInterPro:IPR0005551600115GO_REF:0000002InterProGO_REF:0000002
Brcc3Ratpeptidase activity enablesIEAUniProtKB-KW:KW-06451600115GO_REF:0000043UniProtGO_REF:0000043
Brcc3Ratpolyubiquitin modification-dependent protein binding enablesISSUniProtKB:P467361600115GO_REF:0000024UniProtGO_REF:0000024
Brcc3Ratpolyubiquitin modification-dependent protein binding enablesIBAPANTHER:PTN000045567 and UniProtKB:P467361600115GO_REF:0000033GO_CentralGO_REF:0000033
Brcc3Ratpolyubiquitin modification-dependent protein binding enablesISOBRCC3 (Homo sapiens)1624291 PMID:19261749RGDPMID:19261749
Brcc3Ratprotein binding enablesISOBrcc3 (Mus musculus)1624291PR:Q3TCJ1 more ...RGDPMID:22974638 more ...
1 to 20 of 21 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Brcc3Ratataxia telangiectasia-mutated (ATM) signaling pathway   ISOBRCC3 (Homo sapiens)8661242 RGD 
Brcc3Rathistone modification pathway   ISOBRCC3 (Homo sapiens)9479061 RGD 

#
Reference Title
Reference Citation
1. H2A-DUBbing the mammalian epigenome: expanding frontiers for histone H2A deubiquitinating enzymes in cell biology and physiology. Belle JI and Nijnik A, Int J Biochem Cell Biol. 2014 May;50:161-74. doi: 10.1016/j.biocel.2014.03.004. Epub 2014 Mar 16.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. miR-3940-5p associated with genetic damage in workers exposed to hexavalent chromium. Li Y, etal., Toxicol Lett. 2014 Aug 17;229(1):319-26. doi: 10.1016/j.toxlet.2014.06.033. Epub 2014 Jun 25.
4. Push back to respond better: regulatory inhibition of the DNA double-strand break response. Panier S and Durocher D, Nat Rev Mol Cell Biol. 2013 Oct;14(10):661-72. doi: 10.1038/nrm3659. Epub 2013 Sep 4.
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Identification of genes differentially expressed in mouse fetuses from streptozotocin-induced diabetic pregnancy by cDNA subtraction. Sato N, etal., Endocr J. 2008 May;55(2):317-23. Epub 2008 Mar 7.
PMID:12477932   PMID:14636569   PMID:17525341   PMID:17728463   PMID:19202061   PMID:19214193   PMID:19261746   PMID:19261748   PMID:19261749   PMID:24075985   PMID:25931508   PMID:31184779  
PMID:33979701  



Brcc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr892,073,927 - 2,076,469 (+)NCBIGRCr8
mRatBN7.291,986,942 - 1,989,484 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,986,575 - 1,991,080 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx92,421,214 - 2,423,760 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,770,588 - 7,773,134 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,726,439 - 6,728,985 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.099,863,380 - 9,865,920 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl99,863,404 - 9,865,920 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.098,864,902 - 8,867,442 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera96,530,917 - 6,533,459 (-)NCBICelera
Cytogenetic Map9q11NCBI
BRCC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X155,071,508 - 155,123,077 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX155,071,420 - 155,123,077 (+)EnsemblGRCh38hg38GRCh38
GRCh37X154,299,783 - 154,351,352 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X153,952,904 - 154,004,543 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X153,863,504 - 153,915,052NCBI
CeleraX154,458,427 - 154,510,104 (+)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX142,845,949 - 142,896,583 (+)NCBIHuRef
CHM1_1X154,211,322 - 154,263,032 (+)NCBICHM1_1
T2T-CHM13v2.0X153,307,916 - 153,359,479 (+)NCBIT2T-CHM13v2.0
Brcc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X74,460,234 - 74,499,307 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX74,460,234 - 74,497,607 (+)EnsemblGRCm39 Ensembl
GRCm38X75,416,628 - 75,455,702 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX75,416,628 - 75,454,001 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X72,661,967 - 72,701,040 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X71,669,420 - 71,706,717 (+)NCBIMGSCv36mm8
CeleraX66,818,616 - 66,858,058 (+)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX38.22NCBI
Brcc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955594554,081 - 613,661 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955594551,407 - 613,772 (-)NCBIChiLan1.0ChiLan1.0
BRCC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X155,049,262 - 155,097,994 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X155,052,870 - 155,104,458 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X144,550,320 - 144,592,795 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X154,389,179 - 154,431,616 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX154,389,283 - 154,428,669 (+)Ensemblpanpan1.1panPan2
BRCC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X123,081,262 - 123,143,509 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX123,081,050 - 123,140,133 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX108,074,648 - 108,136,853 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X126,208,828 - 126,271,057 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX126,173,490 - 126,271,057 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X121,956,711 - 122,018,913 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X124,479,132 - 124,541,327 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X124,199,851 - 124,262,068 (+)NCBIUU_Cfam_GSD_1.0
Brcc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X119,982,639 - 120,022,107 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936927341,253 - 376,700 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936927341,114 - 380,817 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BRCC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX125,383,414 - 125,439,082 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X125,383,392 - 125,439,082 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X142,991,891 - 143,046,729 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BRCC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X129,358,759 - 129,406,293 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX129,358,862 - 129,403,352 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606567,336,845 - 67,385,677 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Brcc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624963145,580 - 212,064 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624963142,987 - 212,190 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Brcc3
28 total Variants

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:34
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000071068
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 12 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9114209783Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat

1 to 10 of 12 rows
RH130212  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2398,815,978 - 98,816,168 (+)MAPPERmRatBN7.2
mRatBN7.291,988,828 - 1,989,019 (-)MAPPERmRatBN7.2
Rnor_6.099,863,845 - 9,864,033NCBIRnor6.0
Rnor_6.03103,410,730 - 103,410,919NCBIRnor6.0
Rnor_5.098,865,367 - 8,865,555UniSTSRnor5.0
Rnor_5.03110,004,103 - 110,004,292UniSTSRnor5.0
RGSC_v3.4397,842,396 - 97,842,585UniSTSRGSC3.4
Celera96,531,382 - 6,531,572UniSTS
Celera397,813,856 - 97,814,045UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000071068   ⟹   ENSRNOP00000066438
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl91,986,575 - 1,991,080 (+)Ensembl
Rnor_6.0 Ensembl99,863,404 - 9,865,920 (-)Ensembl
RefSeq Acc Id: NM_001127300   ⟹   NP_001120772
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr892,073,927 - 2,076,469 (+)NCBI
mRatBN7.291,986,942 - 1,989,484 (+)NCBI
Rnor_6.099,863,380 - 9,865,920 (-)NCBI
Rnor_5.098,864,902 - 8,867,442 (-)NCBI
Celera96,530,917 - 6,533,459 (-)RGD
Sequence:
Protein RefSeqs NP_001120772 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66833 (Get FASTA)   NCBI Sequence Viewer  
  B2RYM5 (Get FASTA)   NCBI Sequence Viewer  
  EDL83574 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000066438.1
  ENSRNOP00000101704
RefSeq Acc Id: NP_001120772   ⟸   NM_001127300
- UniProtKB: B2RYM5 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000066438   ⟸   ENSRNOT00000071068
MPN

Name Modeler Protein Id AA Range Protein Structure
AF-B2RYM5-F1-model_v2 AlphaFold B2RYM5 1-291 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13696436
Promoter ID:EPDNEW_R6960
Type:initiation region
Name:Brcc3_1
Description:BRCA1/BRCA2-containing complex, subunit 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.099,865,925 - 9,865,985EPDNEW


1 to 23 of 23 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-28486 BioCyc
Ensembl Genes ENSRNOG00000048061 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000071068.3 UniProtKB/Swiss-Prot
  ENSRNOT00000127736 ENTREZGENE
Gene3D-CATH Cytidine Deaminase, domain 2 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:9021884 IMAGE-MGC_LOAD
InterPro BRCC36_C UniProtKB/Swiss-Prot
  JAMM/MPN+_dom UniProtKB/Swiss-Prot
  JAMM_MPN+_peptidase_M67A UniProtKB/Swiss-Prot
  MPN UniProtKB/Swiss-Prot
  MPN_BRCC36 UniProtKB/Swiss-Prot
KEGG Report rno:316794 UniProtKB/Swiss-Prot
MGC_CLONE MGC:188722 IMAGE-MGC_LOAD
NCBI Gene 316794 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED UniProtKB/Swiss-Prot
Pfam BRCC36_C UniProtKB/Swiss-Prot
  JAB UniProtKB/Swiss-Prot
PhenoGen Brcc3 PhenoGen
PROSITE MPN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000048061 RatGTEx
SMART JAB_MPN UniProtKB/Swiss-Prot
Superfamily-SCOP JAB1/MPN domain UniProtKB/Swiss-Prot
UniProt B2RYM5 ENTREZGENE, UniProtKB/Swiss-Prot
1 to 23 of 23 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-05-05 Brcc3  BRCA1/BRCA2-containing complex subunit 3  Brcc3l1  BRCA1/BRCA2-containing complex, subunit 3 like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2023-04-13 Brcc3l1  BRCA1/BRCA2-containing complex, subunit 3 like 1  Brcc3  BRCA1/BRCA2-containing complex, subunit 3  Name and Symbol changed 629549 APPROVED
2008-03-05 Brcc3  BRCA1/BRCA2-containing complex, subunit 3  LOC316794  similar to BRCA1/BRCA2-containing complex subunit 36 isoform 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC316794  similar to BRCA1/BRCA2-containing complex subunit 36 isoform 2      Symbol and Name status set to provisional 70820 PROVISIONAL