Usp4 (ubiquitin specific peptidase 4) - Rat Genome Database

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Gene: Usp4 (ubiquitin specific peptidase 4) Rattus norvegicus
Analyze
Symbol: Usp4
Name: ubiquitin specific peptidase 4
RGD ID: 1587387
Description: Predicted to enable adenosine receptor binding activity; cysteine-type deubiquitinase activity; and identical protein binding activity. Predicted to be involved in several processes, including positive regulation of TORC1 signaling; protein localization to cell surface; and spliceosomal tri-snRNP complex assembly. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human USP4 (ubiquitin specific peptidase 4); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 3,4-methylenedioxymethamphetamine; aconitine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: deubiquitinating enzyme 4; LOC290864; similar to Ubiquitin carboxyl-terminal hydrolase 4 (Ubiquitin thiolesterase 4) (Ubiquitin-specific processing protease 4) (Deubiquitinating enzyme 4) (Ubiquitous nuclear protein); ubiquitin carboxyl-terminal hydrolase 4; ubiquitin specific peptidase 4 (proto-oncogene); ubiquitin specific protease 4; ubiquitin specific protease 4 (proto-oncogene); ubiquitin thioesterase 4; ubiquitin-specific-processing protease 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,912,576 - 117,957,934 (+)NCBIGRCr8
mRatBN7.28109,035,402 - 109,079,382 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,036,099 - 109,080,427 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8114,663,178 - 114,706,678 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,862,508 - 112,906,009 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08110,705,153 - 110,748,655 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,126,692 - 117,171,012 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,126,692 - 117,171,012 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,474,812 - 116,519,375 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8108,338,833 - 108,383,118 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp4RatAicardi-Goutieres Syndrome 1  ISOUSP4 (Homo sapiens)8554872ClinVar Annotator: match by term: Aicardi-Goutieres syndrome 1ClinVarPMID:16845398 and PMID:28492532
Usp4Ratautosomal recessive limb-girdle muscular dystrophy type 2P  ISOUSP4 (Homo sapiens)8554872ClinVar Annotator: match by term: Autosomal recessive limb-girdle muscular dystrophy type 2PClinVarPMID:20234391 more ...
Usp4Ratcarnitine-acylcarnitine translocase deficiency  ISOUSP4 (Homo sapiens)8554872ClinVar Annotator: match by term: Carnitine acylcarnitine translocase deficiencyClinVarPMID:20234391 more ...
Usp4RatPierson syndrome  ISOUSP4 (Homo sapiens)8554872ClinVar Annotator: match by term: Pierson syndromeClinVarPMID:15367484 and PMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp4Rathepatocellular carcinoma  ISOUSP4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35841383

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp4Rat1,2-dimethylhydrazine multiple interactionsISOUsp4 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of USP4 mRNACTDPMID:22206623
Usp4Rat1,2-dimethylhydrazine affects expressionISOUsp4 (Mus musculus)64804641 and 2-Dimethylhydrazine affects the expression of USP4 mRNACTDPMID:22206623
Usp4Rat17alpha-ethynylestradiol increases expressionISOUsp4 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of USP4 mRNACTDPMID:17942748
Usp4Rat17alpha-ethynylestradiol multiple interactionsISOUsp4 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of USP4 mRNACTDPMID:17942748
Usp4Rat17beta-estradiol increases expressionISOUsp4 (Mus musculus)6480464Estradiol results in increased expression of USP4 mRNACTDPMID:39298647
Usp4Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionEXP 64804642 more ...CTDPMID:27291303
Usp4Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOUsp4 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of USP4 mRNACTDPMID:17942748
Usp4Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOUsp4 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of USP4 mRNACTDPMID:21570461
Usp4Rat3,3',4,4'-tetrachlorobiphenyl multiple interactionsISOUsp4 (Mus musculus)64804643 more ...CTDPMID:19467301
Usp4Rat3,4-methylenedioxymethamphetamine increases expressionISOUsp4 (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of USP4 mRNACTDPMID:26251327
Usp4Rat3,4-methylenedioxymethamphetamine increases expressionEXP 6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of USP4 mRNACTDPMID:30071829
Usp4Rat4,4'-diaminodiphenylmethane decreases expressionISOUsp4 (Mus musculus)64804644 and 4'-diaminodiphenylmethane results in decreased expression of USP4 mRNACTDPMID:18648102
Usp4Rat4,4'-sulfonyldiphenol increases expressionISOUsp4 (Mus musculus)6480464bisphenol S results in increased expression of USP4 mRNACTDPMID:39298647
Usp4Rat4-hydroxyphenyl retinamide increases expressionISOUsp4 (Mus musculus)6480464Fenretinide results in increased expression of USP4 mRNACTDPMID:28973697
Usp4Rataconitine increases expressionEXP 6480464Aconitine results in increased expression of USP4 proteinCTDPMID:33236894
Usp4Ratallethrin multiple interactionsEXP 6480464[cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of USP4 proteinCTDPMID:34896426
Usp4Ratantirheumatic drug decreases expressionISOUSP4 (Homo sapiens)6480464Antirheumatic Agents results in decreased expression of USP4 mRNACTDPMID:24449571
Usp4Ratarsenite(3-) multiple interactionsISOUSP4 (Homo sapiens)6480464arsenite inhibits the reaction [G3BP1 protein binds to USP4 mRNA]CTDPMID:32406909
Usp4Ratbenzo[a]pyrene increases expressionEXP 6480464Benzo(a)pyrene results in increased expression of USP4 mRNACTDPMID:21839799
Usp4Ratbenzo[a]pyrene affects methylationISOUSP4 (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of USP4 3' UTRCTDPMID:27901495

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Biological Process
1 to 20 of 20 rows

  
Object Symbol
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Term
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Reference
Notes
Source
Original Reference(s)
Usp4Ratnegative regulation of protein ubiquitination involved_inISSUniProtKB:Q131071600115GO_REF:0000024UniProtGO_REF:0000024
Usp4Ratnegative regulation of protein ubiquitination involved_inIEAUniProtKB:Q13107 and ensembl:ENSP000002655601600115GO_REF:0000107EnsemblGO_REF:0000107
Usp4Ratnegative regulation of protein ubiquitination involved_inISOUSP4 (Homo sapiens)1624291 PMID:16472766RGDPMID:16472766
Usp4Ratpositive regulation of TORC1 signaling involved_inISSUniProtKB:Q131071600115GO_REF:0000024UniProtGO_REF:0000024
Usp4Ratpositive regulation of TORC1 signaling involved_inIEAUniProtKB:Q13107 and ensembl:ENSP000002655601600115GO_REF:0000107EnsemblGO_REF:0000107
Usp4Ratpositive regulation of TORC1 signaling involved_inISOUSP4 (Homo sapiens)1624291 PMID:30514904RGDPMID:30514904
Usp4Ratprotein deubiquitination involved_inISSUniProtKB:Q131071600115GO_REF:0000024UniProtGO_REF:0000024
Usp4Ratprotein deubiquitination involved_inIEAUniProtKB:Q13107 and ensembl:ENSP000002655601600115GO_REF:0000107EnsemblGO_REF:0000107
Usp4Ratprotein deubiquitination involved_inIEAInterPro:IPR0013941600115GO_REF:0000002InterProGO_REF:0000002
Usp4Ratprotein deubiquitination involved_inISOUSP4 (Homo sapiens)1624291 PMID:16316627 more ...RGDPMID:16316627 more ...
Usp4Ratprotein localization to cell surface involved_inISOUSP4 (Homo sapiens)1624291 PMID:16339847RGDPMID:16339847
Usp4Ratprotein localization to cell surface involved_inIEAUniProtKB:Q13107 and ensembl:ENSP000002655601600115GO_REF:0000107EnsemblGO_REF:0000107
Usp4Ratprotein localization to cell surface involved_inISSUniProtKB:Q131071600115GO_REF:0000024UniProtGO_REF:0000024
Usp4Ratproteolysis involved_inIEAUniProtKB-KW:KW-06451600115GO_REF:0000043UniProtGO_REF:0000043
Usp4Ratregulation of protein stability involved_inISSUniProtKB:Q131071600115GO_REF:0000024UniProtGO_REF:0000024
Usp4Ratregulation of protein stability involved_inIEAUniProtKB:Q13107 and ensembl:ENSP000002655601600115GO_REF:0000107EnsemblGO_REF:0000107
Usp4Ratregulation of protein stability involved_inISOUSP4 (Homo sapiens)1624291 PMID:16472766RGDPMID:16472766
Usp4Ratspliceosomal tri-snRNP complex assembly involved_inISSUniProtKB:Q131071600115GO_REF:0000024UniProtGO_REF:0000024
Usp4Ratspliceosomal tri-snRNP complex assembly involved_inIEAUniProtKB:Q13107 and ensembl:ENSP000002655601600115GO_REF:0000107EnsemblGO_REF:0000107
Usp4Ratspliceosomal tri-snRNP complex assembly involved_inISOUSP4 (Homo sapiens)1624291 PMID:20595234RGDPMID:20595234
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Cellular Component
1 to 11 of 11 rows

  
Object Symbol
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Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp4Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Usp4Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Usp4Ratcytoplasm located_inIEAUniProtKB:Q13107 and ensembl:ENSP000002655601600115GO_REF:0000107EnsemblGO_REF:0000107
Usp4Ratcytoplasm located_inISOUSP4 (Homo sapiens)1624291 PMID:16316627 more ...RGDPMID:16316627 more ...
Usp4Ratcytoplasm located_inISSUniProtKB:Q131071600115GO_REF:0000024UniProtGO_REF:0000024
Usp4Ratnucleus located_inISOUSP4 (Homo sapiens)1624291 PMID:16339847 and PMID:20595234RGDPMID:16339847 and PMID:20595234
Usp4Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Usp4Ratnucleus is_active_inIBAPANTHER:PTN002728652 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Usp4Ratnucleus located_inISSUniProtKB:Q131071600115GO_REF:0000024UniProtGO_REF:0000024
Usp4Ratnucleus located_inIEAUniProtKB:Q13107 and ensembl:ENSP000002655601600115GO_REF:0000107EnsemblGO_REF:0000107
Usp4Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
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Molecular Function
1 to 17 of 17 rows

  
Object Symbol
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Evidence
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Reference
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Source
Original Reference(s)
Usp4Ratadenosine receptor binding enablesISOUSP4 (Homo sapiens)1624291UniProtKB:P29274 and PMID:16339847RGDPMID:16339847
Usp4Ratadenosine receptor binding enablesIEAUniProtKB:Q13107 and ensembl:ENSP000002655601600115GO_REF:0000107EnsemblGO_REF:0000107
Usp4Ratcysteine-type deubiquitinase activity enablesIEAEC:3.4.19.121600115GO_REF:0000003UniProtGO_REF:0000003
Usp4Ratcysteine-type deubiquitinase activity enablesIEAUniRule:UR0008807561600115GO_REF:0000104UniProtGO_REF:0000104
Usp4Ratcysteine-type deubiquitinase activity enablesIEAUniProtKB:Q13107 and ensembl:ENSP000002655601600115GO_REF:0000107EnsemblGO_REF:0000107
Usp4Ratcysteine-type deubiquitinase activity enablesISOUSP4 (Homo sapiens)1624291 PMID:16316627 more ...RGDPMID:16316627 more ...
Usp4Ratcysteine-type deubiquitinase activity enablesIEAInterPro:IPR001394 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Usp4Ratcysteine-type deubiquitinase activity enablesISSUniProtKB:Q131071600115GO_REF:0000024UniProtGO_REF:0000024
Usp4Ratcysteine-type peptidase activity enablesIEAUniProtKB-KW:KW-07881600115GO_REF:0000043UniProtGO_REF:0000043
Usp4Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Usp4Ratidentical protein binding enablesISOUSP4 (Homo sapiens)1624291UniProtKB:Q13107 and PMID:22001210RGDPMID:22001210
Usp4Ratidentical protein binding enablesIEAUniProtKB:Q13107 and ensembl:ENSP000002655601600115GO_REF:0000107EnsemblGO_REF:0000107
Usp4Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Usp4Ratpeptidase activity enablesIEAUniProtKB-KW:KW-06451600115GO_REF:0000043UniProtGO_REF:0000043
Usp4Ratprotein binding enablesISOUSP4 (Homo sapiens) and UniProtKB:Q13107-11624291UniProtKB:P19474 and PMID:11461834RGDPMID:11461834
Usp4Ratprotein binding enablesISOUsp4 (Mus musculus)1624291UniProtKB:P13405 more ...RGDPMID:11571651
Usp4Ratprotein binding enablesISOUSP4 (Homo sapiens)1624291UniProtKB:P29274 more ...RGDPMID:16339847 more ...
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#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:12477932   PMID:16316627   PMID:16339847   PMID:16472766   PMID:20595234   PMID:22001210   PMID:22871113   PMID:27114249   PMID:28755289  



Usp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,912,576 - 117,957,934 (+)NCBIGRCr8
mRatBN7.28109,035,402 - 109,079,382 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,036,099 - 109,080,427 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8114,663,178 - 114,706,678 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,862,508 - 112,906,009 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08110,705,153 - 110,748,655 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,126,692 - 117,171,012 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,126,692 - 117,171,012 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,474,812 - 116,519,375 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8108,338,833 - 108,383,118 (+)NCBICelera
Cytogenetic Map8q32NCBI
USP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38349,277,144 - 49,340,053 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl349,277,144 - 49,340,712 (-)EnsemblGRCh38hg38GRCh38
GRCh37349,314,577 - 49,377,486 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,289,997 - 49,352,519 (-)NCBINCBI36Build 36hg18NCBI36
Build 34349,289,997 - 49,352,519NCBI
Celera349,278,021 - 49,342,350 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef349,371,896 - 49,436,532 (-)NCBIHuRef
CHM1_1349,267,379 - 49,330,367 (-)NCBICHM1_1
T2T-CHM13v2.0349,305,224 - 49,369,431 (-)NCBIT2T-CHM13v2.0
Usp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,223,763 - 108,269,744 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9108,225,052 - 108,269,744 (+)EnsemblGRCm39 Ensembl
GRCm389108,346,564 - 108,392,545 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,347,853 - 108,392,545 (+)EnsemblGRCm38mm10GRCm38
MGSCv379108,250,162 - 108,294,860 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369108,205,963 - 108,250,621 (+)NCBIMGSCv36mm8
Celera9107,957,048 - 108,001,736 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.25NCBI
Usp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555321,247,110 - 1,285,121 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555321,247,110 - 1,284,564 (-)NCBIChiLan1.0ChiLan1.0
LOC100967331
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2249,253,962 - 49,320,547 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1349,258,730 - 49,325,329 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0349,199,328 - 49,263,861 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1350,279,642 - 50,343,901 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl350,279,642 - 50,343,903 (-)Ensemblpanpan1.1panPan2
USP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,899,880 - 39,952,959 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2039,899,897 - 39,952,420 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2039,818,226 - 39,871,287 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02040,256,219 - 40,309,777 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2040,256,236 - 40,309,829 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12039,623,674 - 39,676,723 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02040,027,139 - 40,080,595 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02040,306,950 - 40,360,016 (+)NCBIUU_Cfam_GSD_1.0
Usp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560264,180,540 - 64,229,266 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936529938,501 - 989,884 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936529941,042 - 989,781 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
USP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,848,851 - 31,904,243 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,844,780 - 31,904,418 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,075,799 - 35,135,425 (-)NCBISscrofa10.2Sscrofa10.2susScr3
USP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12210,672,920 - 10,735,374 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2210,672,388 - 10,732,104 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041156,278,755 - 156,354,831 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Usp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247303,253,407 - 3,306,341 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247303,252,980 - 3,306,439 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Usp4
134 total Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
8 116507249 116507250 G A snv COP/CrCrl (MCW & UW) View more Information


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
8 117159094 117159095 G A snv COP/CrCrl (MCW & UW) View more Information

Predicted Target Of
Summary Value
Count of predictions:166
Count of miRNA genes:99
Interacting mature miRNAs:102
Transcripts:ENSRNOT00000071561, ENSRNOT00000073725
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 22 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat

1 to 10 of 22 rows
RH132731  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,080,249 - 109,080,399 (+)MAPPERmRatBN7.2
Rnor_6.08117,170,835 - 117,170,984NCBIRnor6.0
Rnor_5.08116,519,198 - 116,519,347UniSTSRnor5.0
Celera8108,382,941 - 108,383,090UniSTS
Cytogenetic Map16q12.5UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000083046   ⟹   ENSRNOP00000071463
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8109,036,099 - 109,080,427 (+)Ensembl
Rnor_6.0 Ensembl8117,126,692 - 117,171,012 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085609   ⟹   ENSRNOP00000069514
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8109,036,099 - 109,080,427 (+)Ensembl
Rnor_6.0 Ensembl8117,126,692 - 117,171,012 (+)Ensembl
RefSeq Acc Id: NM_001135012   ⟹   NP_001128484
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,914,655 - 117,957,934 (+)NCBI
mRatBN7.28109,036,099 - 109,079,382 (+)NCBI
Rnor_6.08117,126,692 - 117,171,012 (+)NCBI
Rnor_5.08116,474,812 - 116,519,375 (+)NCBI
Celera8108,338,833 - 108,383,118 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039080938   ⟹   XP_038936866
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,933,065 - 117,957,934 (+)NCBI
mRatBN7.28109,054,293 - 109,079,099 (+)NCBI
RefSeq Acc Id: XM_063264999   ⟹   XP_063121069
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,912,576 - 117,957,934 (+)NCBI
RefSeq Acc Id: XM_063265000   ⟹   XP_063121070
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,912,576 - 117,947,143 (+)NCBI
RefSeq Acc Id: XM_063265001   ⟹   XP_063121071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,912,576 - 117,933,058 (+)NCBI
RefSeq Acc Id: XM_063265002   ⟹   XP_063121072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,912,576 - 117,933,058 (+)NCBI
RefSeq Acc Id: XR_010053934
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,912,576 - 117,937,968 (+)NCBI
RefSeq Acc Id: NP_001128484   ⟸   NM_001135012
- UniProtKB: B2GUZ1 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071463   ⟸   ENSRNOT00000083046
Ensembl Acc Id: ENSRNOP00000069514   ⟸   ENSRNOT00000085609
RefSeq Acc Id: XP_038936866   ⟸   XM_039080938
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063121069   ⟸   XM_063264999
- Peptide Label: isoform X1
- UniProtKB: A6I350 (UniProtKB/TrEMBL),   M0R851 (UniProtKB/TrEMBL)
DUSP   Ubiquitin-like   USP

Name Modeler Protein Id AA Range Protein Structure
AF-B2GUZ1-F1-model_v2 AlphaFold B2GUZ1 1-961 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13696298
Promoter ID:EPDNEW_R6822
Type:initiation region
Name:Usp4_1
Description:ubiquitin specific peptidase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08117,126,696 - 117,126,756EPDNEW


1 to 38 of 38 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-29146 BioCyc
Ensembl Genes ENSRNOG00000054863 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000083046 ENTREZGENE
  ENSRNOT00000083046.2 UniProtKB/Swiss-Prot
  ENSRNOT00000085609 ENTREZGENE
Gene3D-CATH 3.30.2230.10 UniProtKB/Swiss-Prot
  Cysteine proteinases UniProtKB/Swiss-Prot
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:9027936 IMAGE-MGC_LOAD
InterPro DUSP-like_sf UniProtKB/Swiss-Prot
  Papain-like_cys_pep_sf UniProtKB/Swiss-Prot
  Pept_C19_DUSP UniProtKB/Swiss-Prot
  Peptidase_C19_UCH UniProtKB/Swiss-Prot
  Ub_carboxyl-term_hydrolase UniProtKB/Swiss-Prot
  Ub_USP-typ UniProtKB/Swiss-Prot
  USP_CS UniProtKB/Swiss-Prot
  USP_dom UniProtKB/Swiss-Prot
KEGG Report rno:290864 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187765 IMAGE-MGC_LOAD
NCBI Gene 290864 ENTREZGENE
PANTHER UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UniProtKB/Swiss-Prot
  UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 4 UniProtKB/Swiss-Prot
Pfam DUSP UniProtKB/Swiss-Prot
  Ubiquitin_3 UniProtKB/Swiss-Prot
  UCH UniProtKB/Swiss-Prot
PhenoGen Usp4 PhenoGen
PROSITE DUSP UniProtKB/Swiss-Prot
  USP_1 UniProtKB/Swiss-Prot
  USP_2 UniProtKB/Swiss-Prot
  USP_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000054863 RatGTEx
SMART DUSP UniProtKB/Swiss-Prot
Superfamily-SCOP SSF143791 UniProtKB/Swiss-Prot
  SSF54001 UniProtKB/Swiss-Prot
UniProt A6I350 ENTREZGENE, UniProtKB/TrEMBL
  B2GUZ1 ENTREZGENE
  M0R851 ENTREZGENE, UniProtKB/TrEMBL
  UBP4_RAT UniProtKB/Swiss-Prot
1 to 38 of 38 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Usp4  ubiquitin specific peptidase 4  Usp4  ubiquitin specific peptidase 4 (proto-oncogene)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Usp4  ubiquitin specific peptidase 4 (proto-oncogene)  LOC290864  similar to Ubiquitin carboxyl-terminal hydrolase 4 (Ubiquitin thiolesterase 4) (Ubiquitin-specific processing protease 4) (Deubiquitinating enzyme 4) (Ubiquitous nuclear protein)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC290864  similar to Ubiquitin carboxyl-terminal hydrolase 4 (Ubiquitin thiolesterase 4) (Ubiquitin-specific processing protease 4) (Deubiquitinating enzyme 4) (Ubiquitous nuclear protein)      Symbol and Name status set to provisional 70820 PROVISIONAL