Nnt (nicotinamide nucleotide transhydrogenase) - Rat Genome Database

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Gene: Nnt (nicotinamide nucleotide transhydrogenase) Rattus norvegicus
Analyze
Symbol: Nnt
Name: nicotinamide nucleotide transhydrogenase
RGD ID: 1587346
Description: Predicted to enable NADP binding activity. Involved in several processes, including cell redox homeostasis; intracellular oxygen homeostasis; and positive regulation of hydrogen peroxide catabolic process. Predicted to be located in mitochondrion. Biomarker of obesity. Human ortholog(s) of this gene implicated in familial glucocorticoid deficiency. Orthologous to human NNT (nicotinamide nucleotide transhydrogenase); PARTICIPATES IN niacin metabolic pathway; nicotinamide adenine dinucleotide metabolic pathway; monoterpenoid biosynthetic pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC109126; NAD(P) transhydrogenase, mitochondrial; nicotinamide nucleotide transhydrogenase (mapped); Nicotinamide nucleotide transhydrogenase (NAD(P)+ transhydrogenase); Nnt_mapped
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8253,144,157 - 53,237,857 (-)NCBIGRCr8
mRatBN7.2251,411,413 - 51,505,125 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl251,411,413 - 51,504,823 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx258,530,027 - 58,623,484 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0256,588,743 - 56,682,196 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0251,516,043 - 51,616,358 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0252,189,523 - 52,283,095 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl252,189,529 - 52,282,548 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0270,553,338 - 70,644,591 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4251,496,456 - 51,589,901 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera247,067,409 - 47,159,610 (-)NCBICelera
Cytogenetic Map2q15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NntRatobesity  IEP 13513980protein:decreased expression:gastrocnemius and soleusRGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NntRatdevelopmental and epileptic encephalopathy  ISONNT (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathyClinVarPMID:28492532
NntRatearly infantile epileptic encephalopathy  ISONNT (Homo sapiens)8554872ClinVar Annotator: match by term: Early infantile epileptic encephalopathyClinVarPMID:28492532
NntRatgenetic disease  ISONNT (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:17576681 more ...
NntRatGlucocorticoid Deficiency 4  ISONNT (Homo sapiens)8554872ClinVar more ...ClinVarPMID:22634753 more ...
NntRatNeurodevelopmental Disorders  ISONNT (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NntRatglucocorticoid deficiency 1  ISONNT (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22634753
Object Symbol
Species
Term
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Reference
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Original Reference(s)
NntRatGlucocorticoid Deficiency 4  ISONNT (Homo sapiens)7240710 OMIM 

1 to 20 of 137 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NntRat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of NNT mRNA]CTDPMID:31150632
NntRat1,1-dichloroethene decreases expressionISONnt (Mus musculus)6480464vinylidene chloride results in decreased expression of NNT mRNACTDPMID:26682919
NntRat1,2-dimethylhydrazine multiple interactionsISONnt (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of NNT mRNACTDPMID:22206623
NntRat1,2-dimethylhydrazine decreases expressionISONnt (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of NNT mRNACTDPMID:22206623
NntRat17alpha-ethynylestradiol affects expressionEXP 6480464Ethinyl Estradiol affects the expression of NNT mRNACTDPMID:16079270
NntRat17beta-estradiol affects expressionISONNT (Homo sapiens)6480464Estradiol affects the expression of NNT mRNACTDPMID:22574217
NntRat17beta-estradiol decreases expressionISONnt (Mus musculus)6480464Estradiol results in decreased expression of NNT mRNACTDPMID:39298647
NntRat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of NNT proteinCTDPMID:32145629
NntRat17beta-estradiol multiple interactionsEXP 6480464[bisphenol A co-treated with Estradiol] results in decreased expression of NNT mRNACTDPMID:26496021
NntRat17beta-hydroxy-5alpha-androstan-3-one increases expressionISONNT (Homo sapiens)6480464Dihydrotestosterone results in increased expression of NNT mRNACTDPMID:29581250
NntRat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISONnt (Mus musculus)6480464[2 more ...CTDPMID:25510870
NntRat2,2',5,5'-tetrachlorobiphenyl multiple interactionsISONnt (Mus musculus)6480464[2 more ...CTDPMID:25510870
NntRat2,2,2-tetramine multiple interactionsEXP 6480464Trientine inhibits the reaction [Streptozocin results in increased expression of NNT protein]CTDPMID:19634143
NntRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISONnt (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with AHR gene mutant form] results in increased expression of NNT mRNACTDPMID:19465110
NntRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISONNT (Homo sapiens)6480464[Tetrachlorodibenzodioxin co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] results in increased expression of NNT mRNACTDPMID:29704546
NntRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISONnt (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of NNT mRNACTDPMID:21570461
NntRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISONNT (Homo sapiens)6480464Tetrachlorodibenzodioxin affects the expression of NNT mRNACTDPMID:22298810
NntRat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of NNT mRNACTDPMID:22298810
NntRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of NNT mRNACTDPMID:21215274 and PMID:33387578
NntRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISONnt (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of NNT mRNACTDPMID:19770486

1 to 20 of 137 rows

Biological Process
1 to 13 of 13 rows

  
1 to 13 of 13 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NntRatmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
NntRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
NntRatmitochondrion located_inIEAUniProtKB:Q13423 and ensembl:ENSP000003438731600115GO_REF:0000107EnsemblGO_REF:0000107
NntRatmitochondrion located_inISONNT (Homo sapiens)1624291 RGDGO_REF:0000054

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NntRatNADP binding enablesISONNT (Homo sapiens)1624291 PMID:10673423RGDPMID:10673423
NntRatNADP binding enablesIBAPANTHER:PTN000017743 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
NntRatNADP binding enablesIEAUniProtKB:Q13423 and ensembl:ENSP000003438731600115GO_REF:0000107EnsemblGO_REF:0000107
NntRatoxidoreductase activity enablesIEAInterPro:IPR008142 and InterPro:IPR0081431600115GO_REF:0000002InterProGO_REF:0000002
NntRatoxidoreductase activity enablesIEAInterPro:IPR0081431600115GO_REF:0000002InterProGO_REF:0000002
NntRatproton-translocating NAD(P)+ transhydrogenase activity enablesIEAEC:7.1.1.11600115GO_REF:0000003UniProtGO_REF:0000003

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NntRatnicotinamide adenine dinucleotide metabolic pathway   ISONNT (Homo sapiens)11099972 RGD 

Imported Annotations - SMPDB

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NntRatniacin metabolic pathway  ISONNT (Homo sapiens)10402751 SMPDBSMP:00048

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NntRatmonoterpenoid biosynthetic pathway  IEA 6907045 KEGGrno:00760
NntRatniacin metabolic pathway  IEA 6907045 KEGGrno:00760

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#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. Houtkooper RH, etal., Endocr Rev. 2010 Apr;31(2):194-223. doi: 10.1210/er.2009-0026. Epub 2009 Dec 9.
3. Nicotinamide nucleotide transhydrogenase (Nnt) links the substrate requirement in brain mitochondria for hydrogen peroxide removal to the thioredoxin/peroxiredoxin (Trx/Prx) system. Lopert P and Patel M, J Biol Chem. 2014 May 30;289(22):15611-20. doi: 10.1074/jbc.M113.533653. Epub 2014 Apr 10.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. Vitamin E and vitamin C do not reduce insulin sensitivity but inhibit mitochondrial protein expression in exercising obese rats. Picklo MJ and Thyfault JP, Appl Physiol Nutr Metab. 2015 Apr;40(4):343-52. doi: 10.1139/apnm-2014-0302. Epub 2014 Dec 9.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Information Derived from GenBank Report RGD, Sept. 2003
13. Silencing of nicotinamide nucleotide transhydrogenase impairs cellular redox homeostasis and energy metabolism in PC12 cells. Yin F, etal., Biochim Biophys Acta. 2012 Mar;1817(3):401-9. doi: 10.1016/j.bbabio.2011.12.004. Epub 2011 Dec 16.
1 to 13 of 13 rows
PMID:9271681   PMID:10673423   PMID:12477932   PMID:12865426   PMID:14651853   PMID:18614015   PMID:19946888   PMID:22634753   PMID:25002582  



Nnt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8253,144,157 - 53,237,857 (-)NCBIGRCr8
mRatBN7.2251,411,413 - 51,505,125 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl251,411,413 - 51,504,823 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx258,530,027 - 58,623,484 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0256,588,743 - 56,682,196 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0251,516,043 - 51,616,358 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0252,189,523 - 52,283,095 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl252,189,529 - 52,282,548 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0270,553,338 - 70,644,591 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4251,496,456 - 51,589,901 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera247,067,409 - 47,159,610 (-)NCBICelera
Cytogenetic Map2q15NCBI
NNT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38543,602,675 - 43,707,396 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl543,602,692 - 43,707,405 (+)EnsemblGRCh38hg38GRCh38
GRCh37543,602,777 - 43,707,498 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36543,638,548 - 43,741,425 (+)NCBINCBI36Build 36hg18NCBI36
Build 34543,639,063 - 43,741,091NCBI
Celera543,495,188 - 43,598,076 (+)NCBICelera
Cytogenetic Map5p12NCBI
HuRef543,555,411 - 43,658,307 (+)NCBIHuRef
CHM1_1543,604,210 - 43,707,124 (+)NCBICHM1_1
T2T-CHM13v2.0543,849,920 - 43,961,029 (+)NCBIT2T-CHM13v2.0
Nnt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913119,472,063 - 119,545,793 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13119,471,984 - 119,545,533 (-)EnsemblGRCm39 Ensembl
GRCm39 Ensembl13119,472,064 - 119,545,488 (-)EnsemblGRCm39 Ensembl
GRCm3813119,335,527 - 119,409,257 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13119,335,448 - 119,408,997 (-)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl13119,335,528 - 119,408,952 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713120,124,334 - 120,197,945 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613120,453,190 - 120,527,884 (-)NCBIMGSCv36mm8
Celera13123,765,363 - 123,860,935 (-)NCBICelera
Cytogenetic Map13D2.3NCBI
cM Map1367.21NCBI
Nnt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544618,685,516 - 18,778,024 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544618,685,511 - 18,778,024 (-)NCBIChiLan1.0ChiLan1.0
NNT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2466,619,709 - 66,724,900 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1564,774,508 - 64,878,384 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0566,662,249 - 66,772,352 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1571,719,257 - 71,823,259 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl571,719,257 - 71,823,242 (-)Ensemblpanpan1.1panPan2
NNT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1466,348,222 - 66,437,889 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl466,349,318 - 66,442,841 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha466,108,885 - 66,203,350 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0466,840,719 - 66,935,030 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl466,840,739 - 66,934,534 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1466,598,942 - 66,693,215 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0466,729,845 - 66,824,004 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0467,265,089 - 67,359,365 (-)NCBIUU_Cfam_GSD_1.0
Nnt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213209,662,542 - 209,755,562 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648018,598,481 - 18,691,859 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648018,599,037 - 18,692,097 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NNT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1628,157,318 - 28,250,961 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11628,157,192 - 28,248,732 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21629,706,049 - 29,756,286 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NNT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1442,377,979 - 42,476,247 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl442,384,435 - 42,477,002 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607132,851,165 - 32,963,567 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nnt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475911,521,778 - 11,628,716 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475911,520,793 - 11,628,003 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Nnt
588 total Variants

Predicted Target Of
Summary Value
Count of predictions:427
Count of miRNA genes:226
Interacting mature miRNAs:264
Transcripts:ENSRNOT00000033627
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 46 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22238462767384627Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23502311780023117Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat

1 to 10 of 46 rows
D2Rat318  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8253,197,569 - 53,197,762 (+)Marker Load Pipeline
mRatBN7.2251,464,829 - 51,465,022 (+)MAPPERmRatBN7.2
Rnor_6.0252,243,066 - 52,243,258NCBIRnor6.0
Rnor_5.0270,605,933 - 70,606,125UniSTSRnor5.0
RGSC_v3.4251,551,169 - 51,551,359RGDRGSC3.4
RGSC_v3.4251,551,170 - 51,551,362UniSTSRGSC3.4
RGSC_v3.1251,479,402 - 51,479,592RGD
Celera247,119,907 - 47,120,100UniSTS
SHRSP x BN Map222.9498UniSTS
SHRSP x BN Map222.9498RGD
Cytogenetic Map2q16UniSTS
RH139449  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2251,462,839 - 51,462,976 (+)MAPPERmRatBN7.2
Rnor_6.0252,241,076 - 52,241,212NCBIRnor6.0
Rnor_5.0270,603,943 - 70,604,079UniSTSRnor5.0
RGSC_v3.4251,549,180 - 51,549,316UniSTSRGSC3.4
Celera247,117,917 - 47,118,053UniSTS
RH 3.4 Map2332.1UniSTS
Cytogenetic Map2q16UniSTS
RH128163  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2251,411,670 - 51,411,873 (+)MAPPERmRatBN7.2
Rnor_6.0252,189,784 - 52,189,986NCBIRnor6.0
Rnor_5.0270,553,600 - 70,553,802UniSTSRnor5.0
RGSC_v3.4251,496,714 - 51,496,916UniSTSRGSC3.4
Celera247,067,667 - 47,067,869UniSTS
RH 3.4 Map2332.9UniSTS
Cytogenetic Map2q16UniSTS
BE115925  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8253,171,072 - 53,171,230 (+)Marker Load Pipeline
mRatBN7.2251,438,332 - 51,438,490 (+)MAPPERmRatBN7.2
Rnor_6.0252,216,593 - 52,216,750NCBIRnor6.0
Rnor_5.0270,580,409 - 70,580,566UniSTSRnor5.0
RGSC_v3.4251,523,376 - 51,523,533UniSTSRGSC3.4
Celera247,094,327 - 47,094,484UniSTS
RH 3.4 Map2332.1UniSTS
Cytogenetic Map2q16UniSTS
BE117824  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2251,506,085 - 51,506,285 (+)MAPPERmRatBN7.2
Rnor_6.0252,284,053 - 52,284,252NCBIRnor6.0
Rnor_5.0270,645,578 - 70,645,777UniSTSRnor5.0
Celera247,161,109 - 47,161,308UniSTS
RH 3.4 Map2333.6UniSTS
Cytogenetic Map2q16UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 19 of 19 rows
RefSeq Transcripts NM_001013157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC098186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC091271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 19 of 19 rows

Ensembl Acc Id: ENSRNOT00000033627   ⟹   ENSRNOP00000029578
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl251,411,413 - 51,504,628 (-)Ensembl
Rnor_6.0 Ensembl252,189,529 - 52,282,548 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103489   ⟹   ENSRNOP00000085139
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl251,411,486 - 51,504,823 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107063   ⟹   ENSRNOP00000094975
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl251,411,413 - 51,504,628 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108201   ⟹   ENSRNOP00000090631
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl251,411,413 - 51,504,628 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112693   ⟹   ENSRNOP00000090109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl251,411,413 - 51,504,628 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116756   ⟹   ENSRNOP00000096310
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl251,411,413 - 51,504,191 (-)Ensembl
RefSeq Acc Id: NM_001013157   ⟹   NP_001013175
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8253,144,157 - 53,237,310 (-)NCBI
mRatBN7.2251,411,413 - 51,504,578 (-)NCBI
Rnor_6.0252,189,526 - 52,282,548 (-)NCBI
Rnor_5.0270,553,338 - 70,644,591 (-)NCBI
RGSC_v3.4251,496,456 - 51,589,901 (-)RGD
Celera247,067,409 - 47,159,610 (-)RGD
Sequence:
RefSeq Acc Id: XM_006231968   ⟹   XP_006232030
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8253,144,157 - 53,237,644 (-)NCBI
mRatBN7.2251,412,134 - 51,504,909 (-)NCBI
Rnor_6.0252,189,523 - 52,282,860 (-)NCBI
Rnor_5.0270,553,338 - 70,644,591 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006231969   ⟹   XP_006232031
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8253,144,157 - 53,237,635 (-)NCBI
mRatBN7.2251,412,134 - 51,504,903 (-)NCBI
Rnor_6.0252,189,523 - 52,282,860 (-)NCBI
Rnor_5.0270,553,338 - 70,644,591 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006231970   ⟹   XP_006232032
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8253,144,157 - 53,236,943 (-)NCBI
mRatBN7.2251,412,134 - 51,504,243 (-)NCBI
Rnor_6.0252,189,523 - 52,282,228 (-)NCBI
Rnor_5.0270,553,338 - 70,644,591 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006231971   ⟹   XP_006232033
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8253,144,157 - 53,237,140 (-)NCBI
mRatBN7.2251,412,134 - 51,504,412 (-)NCBI
Rnor_6.0252,189,523 - 52,282,348 (-)NCBI
Rnor_5.0270,553,338 - 70,644,591 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006231972   ⟹   XP_006232034
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8253,144,157 - 53,237,325 (-)NCBI
mRatBN7.2251,412,134 - 51,504,594 (-)NCBI
Rnor_6.0252,189,523 - 52,282,591 (-)NCBI
Rnor_5.0270,553,338 - 70,644,591 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008760774   ⟹   XP_008758996
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8253,144,157 - 53,237,857 (-)NCBI
mRatBN7.2251,412,134 - 51,505,125 (-)NCBI
Rnor_6.0252,189,523 - 52,283,095 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039102256   ⟹   XP_038958184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8253,144,157 - 53,236,508 (-)NCBI
mRatBN7.2251,411,413 - 51,503,138 (-)NCBI
RefSeq Acc Id: XM_039102257   ⟹   XP_038958185
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8253,144,157 - 53,235,869 (-)NCBI
mRatBN7.2251,411,419 - 51,503,143 (-)NCBI
RefSeq Acc Id: XM_063281783   ⟹   XP_063137853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8253,144,157 - 53,237,857 (-)NCBI
RefSeq Acc Id: XM_063281784   ⟹   XP_063137854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8253,144,157 - 53,237,153 (-)NCBI
RefSeq Acc Id: XM_063281785   ⟹   XP_063137855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8253,144,157 - 53,237,325 (-)NCBI
1 to 5 of 18 rows
1 to 5 of 18 rows
RefSeq Acc Id: NP_001013175   ⟸   NM_001013157
- UniProtKB: Q5BJZ3 (UniProtKB/TrEMBL),   A0A8I6A0P0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232030   ⟸   XM_006231968
- Peptide Label: isoform X2
- UniProtKB: Q5BJZ3 (UniProtKB/TrEMBL),   A0A8I6A0P0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232031   ⟸   XM_006231969
- Peptide Label: isoform X2
- UniProtKB: Q5BJZ3 (UniProtKB/TrEMBL),   A0A8I6A0P0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232034   ⟸   XM_006231972
- Peptide Label: isoform X2
- UniProtKB: Q5BJZ3 (UniProtKB/TrEMBL),   A0A8I6A0P0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232033   ⟸   XM_006231971
- Peptide Label: isoform X2
- UniProtKB: Q5BJZ3 (UniProtKB/TrEMBL),   A0A8I6A0P0 (UniProtKB/TrEMBL)
- Sequence:
Alanine dehydrogenase/pyridine nucleotide

Name Modeler Protein Id AA Range Protein Structure
AF-Q5BJZ3-F1-model_v2 AlphaFold Q5BJZ3 1-1086 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13691156
Promoter ID:EPDNEW_R1680
Type:initiation region
Name:Nnt_1
Description:nicotinamide nucleotide transhydrogenase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0252,282,547 - 52,282,607EPDNEW


1 to 40 of 52 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-54293 BioCyc
BioCyc Pathway NADPHOS-DEPHOS-PWY [NAD phosphorylation and dephosphorylation] BioCyc
  NADPHOS-DEPHOS-PWY-1 [NAD phosphorylation and transhydrogenation] BioCyc
BioCyc Pathway Image NADPHOS-DEPHOS-PWY BioCyc
  NADPHOS-DEPHOS-PWY-1 BioCyc
Ensembl Genes ENSRNOG00000026842 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033627 ENTREZGENE
  ENSRNOT00000033627.4 UniProtKB/TrEMBL
  ENSRNOT00000103489 ENTREZGENE
  ENSRNOT00000103489.1 UniProtKB/TrEMBL
  ENSRNOT00000107063.1 UniProtKB/TrEMBL
  ENSRNOT00000108201 ENTREZGENE
  ENSRNOT00000108201.1 UniProtKB/TrEMBL
  ENSRNOT00000112693.1 UniProtKB/TrEMBL
  ENSRNOT00000116756.1 UniProtKB/TrEMBL
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
  TPP-binding domain UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7381610 IMAGE-MGC_LOAD
InterPro Ala_DH/PNT_C UniProtKB/TrEMBL
  Ala_DH/PNT_CS1 UniProtKB/TrEMBL
  Ala_DH/PNT_CS2 UniProtKB/TrEMBL
  Ala_DH/PNT_N UniProtKB/TrEMBL
  DHS-like_NAD/FAD-binding_dom UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  NADP_transhyd_a UniProtKB/TrEMBL
  NADP_transhyd_a_C UniProtKB/TrEMBL
  PNTB-like UniProtKB/TrEMBL
KEGG Report rno:310378 UniProtKB/TrEMBL
MGC_CLONE MGC:109126 IMAGE-MGC_LOAD
NCBI Gene 310378 ENTREZGENE
PANTHER NAD(P) TRANSHYDROGENASE UniProtKB/TrEMBL
  NAD(P) TRANSHYDROGENASE, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam AlaDh_PNT_C UniProtKB/TrEMBL
  AlaDh_PNT_N UniProtKB/TrEMBL
  DUF3814 UniProtKB/TrEMBL
  PNTB UniProtKB/TrEMBL
PhenoGen Nnt PhenoGen
PROSITE ALADH_PNT_1 UniProtKB/TrEMBL
  ALADH_PNT_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000026842 RatGTEx
1 to 40 of 52 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-04-13   nicotinamide nucleotide transhydrogenase  Nnt  nicotinamide nucleotide transhydrogenase (mapped)  Name updated 737654 APPROVED
2007-04-11 Nnt  nicotinamide nucleotide transhydrogenase (mapped)  Nnt_mapped  nicotinamide nucleotide transhydrogenase (mapped)  Data merged from RGD:3182 737654 APPROVED
2006-11-19 Nnt  nicotinamide nucleotide transhydrogenase (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Nnt_mapped  nicotinamide nucleotide transhydrogenase (mapped)  Nnt  nicotinamide nucleotide transhydrogenase  Symbol and Name updated 1556543 APPROVED
2002-06-10 Nnt  Nicotinamide nucleotide transhydrogenase (NAD(P)+ transhydrogenase)      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_homology mouse Nnt exhibits NAD(P) transhydrogenase and oxidoreductase activities 704405