Usp26 (ubiquitin specific peptidase 26) - Rat Genome Database

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Gene: Usp26 (ubiquitin specific peptidase 26) Rattus norvegicus
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Symbol: Usp26
Name: ubiquitin specific peptidase 26
RGD ID: 1563443
Description: Predicted to enable K48-linked deubiquitinase activity and cysteine-type deubiquitinase activity. Predicted to be involved in several processes, including G1/S transition of mitotic cell cycle; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; and regulation of androgen receptor signaling pathway. Predicted to be located in nucleoplasm and sperm flagellum. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in spermatogenic failure. Orthologous to human USP26 (ubiquitin specific peptidase 26); INTERACTS WITH bisphenol A; 2,3',4,4',5-Pentachlorobiphenyl (ortholog); 2,3,7,8-tetrachlorodibenzodioxine (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC108353303; LOC302488; RGD1563443; similar to ubiquitin specific protease; ubiquitin carboxyl-terminal hydrolase 26; uncharacterized LOC108353303
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X136,237,504 - 136,284,646 (-)NCBIGRCr8
mRatBN7.2X131,317,200 - 131,363,964 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX131,319,194 - 131,363,970 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX133,476,889 - 133,520,935 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X137,058,822 - 137,102,868 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X134,633,247 - 134,677,367 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X139,030,239 - 139,079,336 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX139,030,804 - 139,079,336 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X139,084,571 - 139,131,158 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X138,625,478 - 138,669,690 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX130,238,525 - 130,282,649 (-)NCBICelera
Cytogenetic MapXq36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA,ISO)
nucleoplasm  (ISO)
nucleus  (IBA,ISO)
sperm flagellum  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:20501646  


Genomics

Comparative Map Data
Usp26
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X136,237,504 - 136,284,646 (-)NCBIGRCr8
mRatBN7.2X131,317,200 - 131,363,964 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX131,319,194 - 131,363,970 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX133,476,889 - 133,520,935 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X137,058,822 - 137,102,868 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X134,633,247 - 134,677,367 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X139,030,239 - 139,079,336 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX139,030,804 - 139,079,336 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X139,084,571 - 139,131,158 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X138,625,478 - 138,669,690 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX130,238,525 - 130,282,649 (-)NCBICelera
Cytogenetic MapXq36NCBI
USP26
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X133,023,168 - 133,097,109 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX133,023,168 - 133,097,109 (-)EnsemblGRCh38hg38GRCh38
GRCh37X132,157,196 - 132,231,137 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X131,987,173 - 131,989,966 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X131,885,026 - 131,887,820NCBI
CeleraX132,545,874 - 132,548,667 (-)NCBICelera
Cytogenetic MapXq26.2NCBI
HuRefX121,562,395 - 121,565,188 (-)NCBIHuRef
CHM1_1X132,071,082 - 132,073,875 (-)NCBICHM1_1
T2T-CHM13v2.0X131,347,885 - 131,421,825 (-)NCBIT2T-CHM13v2.0
Usp26
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X50,841,544 - 50,890,110 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX50,842,836 - 50,890,110 (-)EnsemblGRCm39 Ensembl
GRCm38X51,752,667 - 51,801,233 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX51,753,959 - 51,801,233 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X49,107,136 - 49,154,410 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X47,998,586 - 48,042,380 (-)NCBIMGSCv36mm8
CeleraX39,175,908 - 39,222,874 (-)NCBICelera
Cytogenetic MapXA5NCBI
cM MapX28.31NCBI
Usp26
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554731,903,865 - 1,957,747 (+)NCBIChiLan1.0ChiLan1.0
USP26
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X132,433,181 - 132,493,776 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X132,436,775 - 132,497,371 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X122,155,933 - 122,160,000 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X132,463,139 - 132,465,933 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX132,463,140 - 132,465,887 (-)Ensemblpanpan1.1panPan2
USP26
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X103,869,903 - 103,930,495 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX103,872,397 - 103,875,171 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX90,042,316 - 90,060,916 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X105,726,832 - 105,789,778 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX105,729,326 - 105,732,100 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X103,140,338 - 103,203,243 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X105,015,482 - 105,072,425 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X104,789,168 - 104,852,070 (-)NCBIUU_Cfam_GSD_1.0
Usp26
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X102,040,698 - 102,044,002 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366911,913,416 - 1,916,214 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
USP26
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1X109,092,622 - 109,095,548 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X125,124,840 - 125,177,383 (-)NCBISscrofa10.2Sscrofa10.2susScr3
USP26
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X108,187,526 - 108,275,829 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX108,187,858 - 108,190,605 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606545,699,469 - 45,702,346 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Usp26
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479712,724,584 - 12,797,308 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Usp26
185 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:426
Count of miRNA genes:239
Interacting mature miRNAs:291
Transcripts:ENSRNOT00000047605
Prediction methods:Microtar, Miranda, Pita, Pita,Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX112934952138400867Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 12
Low 1 1 15 17 1
Below cutoff 5 9 4 3 4 2 2 4 16 8 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000047605   ⟹   ENSRNOP00000047375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX131,319,717 - 131,363,846 (-)Ensembl
Rnor_6.0 EnsemblX139,030,804 - 139,079,336 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116818   ⟹   ENSRNOP00000085992
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX131,319,194 - 131,363,970 (-)Ensembl
RefSeq Acc Id: NM_001106948   ⟹   NP_001100418
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X136,240,379 - 136,284,507 (-)NCBI
mRatBN7.2X131,319,717 - 131,363,846 (-)NCBI
Rnor_6.0X139,030,804 - 139,079,336 (-)NCBI
Rnor_5.0X139,084,571 - 139,131,158 (-)NCBI
RGSC_v3.4X138,625,478 - 138,669,690 (-)RGD
CeleraX130,238,525 - 130,282,649 (-)RGD
Sequence:
RefSeq Acc Id: XM_039099603   ⟹   XP_038955531
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X136,237,504 - 136,284,646 (-)NCBI
mRatBN7.2X131,317,200 - 131,363,964 (-)NCBI
RefSeq Acc Id: XM_039099605   ⟹   XP_038955533
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X136,237,504 - 136,284,625 (-)NCBI
mRatBN7.2X131,317,200 - 131,363,964 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001100418 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955531 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955533 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM10949 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000047375
  ENSRNOP00000047375.3
  ENSRNOP00000085992
  ENSRNOP00000085992.1
Reference Protein Sequences
RefSeq Acc Id: NP_001100418   ⟸   NM_001106948
- UniProtKB: D4A5S1 (UniProtKB/TrEMBL),   A6JMT7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000047375   ⟸   ENSRNOT00000047605
RefSeq Acc Id: XP_038955531   ⟸   XM_039099603
- Peptide Label: isoform X1
- UniProtKB: D4A5S1 (UniProtKB/TrEMBL),   A6JMT7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955533   ⟸   XM_039099605
- Peptide Label: isoform X1
- UniProtKB: D4A5S1 (UniProtKB/TrEMBL),   A6JMT7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000085992   ⟸   ENSRNOT00000116818
Protein Domains
USP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A5S1-F1-model_v2 AlphaFold D4A5S1 1-827 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563443 AgrOrtholog
BioCyc Gene G2FUF-1042 BioCyc
Ensembl Genes ENSRNOG00000029106 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000047605 ENTREZGENE
  ENSRNOT00000047605.6 UniProtKB/TrEMBL
  ENSRNOT00000116818.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.180 UniProtKB/TrEMBL
  Cysteine proteinases UniProtKB/TrEMBL
InterPro Papain_like_cys_pep_sf UniProtKB/TrEMBL
  Pept_C19ubi-hydrolase_C_CS UniProtKB/TrEMBL
  Peptidase_C19 UniProtKB/TrEMBL
  UCH/PAN2 UniProtKB/TrEMBL
  UCH_N UniProtKB/TrEMBL
  USP37-like_PH_sf UniProtKB/TrEMBL
KEGG Report rno:302488 UniProtKB/TrEMBL
NCBI Gene 302488 ENTREZGENE
PANTHER UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UniProtKB/TrEMBL
  UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 26 UniProtKB/TrEMBL
Pfam UCH UniProtKB/TrEMBL
  UCH_N UniProtKB/TrEMBL
PhenoGen Usp26 PhenoGen
PROSITE UCH_2_1 UniProtKB/TrEMBL
  UCH_2_2 UniProtKB/TrEMBL
  UCH_2_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029106 RatGTEx
Superfamily-SCOP SSF54001 UniProtKB/TrEMBL
UniProt A6JMT7 ENTREZGENE, UniProtKB/TrEMBL
  D4A5S1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Usp26  ubiquitin specific peptidase 26  LOC108353303  uncharacterized LOC108353303  Data merged from RGD:11428360 737654 PROVISIONAL
2016-08-02 LOC108353303  uncharacterized LOC108353303      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Usp26  ubiquitin specific peptidase 26   Usp26_predicted  ubiquitin specific peptidase 26 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Usp26_predicted  ubiquitin specific peptidase 26 (predicted)  RGD1563443_predicted  similar to ubiquitin specific protease (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1563443_predicted  similar to ubiquitin specific protease (predicted)  LOC302488  similar to ubiquitin specific protease  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC302488  similar to ubiquitin specific protease      Symbol and Name status set to provisional 70820 PROVISIONAL