Otud1 (OTU deubiquitinase 1) - Rat Genome Database

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Gene: Otud1 (OTU deubiquitinase 1) Rattus norvegicus
Analyze
Symbol: Otud1
Name: OTU deubiquitinase 1
RGD ID: 1563344
Description: Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in protein metabolic process. Orthologous to human OTUD1 (OTU deubiquitinase 1); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC498803; OTU domain containing 1; OTU domain-containing protein 1; RGD1563344; similar to OTU domain containing 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81787,168,248 - 87,171,098 (+)NCBIGRCr8
mRatBN7.21782,259,920 - 82,262,770 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1782,259,840 - 82,262,995 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1785,724,940 - 85,727,790 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01789,560,362 - 89,563,213 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01783,577,116 - 83,579,967 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01786,406,643 - 86,410,670 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1786,408,151 - 86,409,518 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01788,116,903 - 88,120,492 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41793,707,499 - 93,710,025 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1781,524,969 - 81,534,067 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
1,2-dichloroethane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
dibutyl phthalate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
indole-3-methanol  (EXP)
iron dichloride  (ISO)
lipopolysaccharide  (ISO)
metformin  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
N-nitrosodiethylamine  (EXP)
nickel sulfate  (ISO)
niclosamide  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
Soman  (EXP)
sulindac  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:23827681  


Genomics

Comparative Map Data
Otud1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81787,168,248 - 87,171,098 (+)NCBIGRCr8
mRatBN7.21782,259,920 - 82,262,770 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1782,259,840 - 82,262,995 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1785,724,940 - 85,727,790 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01789,560,362 - 89,563,213 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01783,577,116 - 83,579,967 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01786,406,643 - 86,410,670 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1786,408,151 - 86,409,518 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01788,116,903 - 88,120,492 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41793,707,499 - 93,710,025 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1781,524,969 - 81,534,067 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
OTUD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381023,439,075 - 23,442,377 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1023,439,075 - 23,442,377 (+)EnsemblGRCh38hg38GRCh38
GRCh371023,728,004 - 23,731,306 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361023,767,592 - 23,771,316 (+)NCBINCBI36Build 36hg18NCBI36
Celera1023,416,596 - 23,419,451 (+)NCBICelera
Cytogenetic Map10p12.2NCBI
HuRef1023,388,912 - 23,392,024 (+)NCBIHuRef
CHM1_11023,728,577 - 23,731,689 (+)NCBICHM1_1
T2T-CHM13v2.01023,459,207 - 23,462,509 (+)NCBIT2T-CHM13v2.0
Otud1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39219,662,542 - 19,666,090 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl219,662,563 - 19,665,394 (+)EnsemblGRCm39 Ensembl
GRCm38219,657,731 - 19,661,279 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl219,657,752 - 19,660,583 (+)EnsemblGRCm38mm10GRCm38
MGSCv37219,579,689 - 19,582,217 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36219,573,560 - 19,578,344 (+)NCBIMGSCv36mm8
Celera219,550,304 - 19,552,833 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map213.78NCBI
Otud1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554295,588,333 - 5,590,220 (-)NCBIChiLan1.0ChiLan1.0
OTUD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2836,136,514 - 36,139,640 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11036,141,860 - 36,144,966 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01023,612,632 - 23,614,830 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11023,985,437 - 23,988,425 (+)NCBIpanpan1.1PanPan1.1panPan2
OTUD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.129,746,652 - 9,768,868 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha28,439,201 - 8,529,306 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.027,949,157 - 8,039,598 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl28,037,867 - 8,039,357 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.127,315,556 - 7,405,754 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.027,398,871 - 7,489,616 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.027,566,596 - 7,656,887 (-)NCBIUU_Cfam_GSD_1.0
Otud1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934423,202,882 - 23,206,488 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365204,753,989 - 4,757,595 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OTUD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1051,619,680 - 51,621,116 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11051,618,442 - 51,621,309 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21057,272,982 - 57,275,557 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OTUD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1923,203,950 - 23,206,996 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl923,204,327 - 23,205,766 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605128,968,679 - 28,971,733 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Otud1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247965,350,716 - 5,351,834 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247965,349,503 - 5,351,828 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Otud1
8 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:27
Count of miRNA genes:26
Interacting mature miRNAs:27
Transcripts:ENSRNOT00000022734
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
1358295Aocep1Aortic cell protein QTL 16.10.00000071thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175349882882479847Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)176078142686533673Rat
7411577Bw141Body weight QTL 1410.001body mass (VT:0001259)body weight gain (CMO:0000420)176261951686533673Rat
12904736Cm121Cardiac mass QTL 1210.043heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)177177462182479847Rat

Markers in Region
RH143754  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21782,260,910 - 82,261,171 (+)MAPPERmRatBN7.2
Rnor_6.01786,408,811 - 86,409,071NCBIRnor6.0
Rnor_5.01788,118,631 - 88,118,891UniSTSRnor5.0
RGSC_v3.41793,708,159 - 93,708,419UniSTSRGSC3.4
Celera1781,532,208 - 81,532,468UniSTS
RH 3.4 Map17836.5UniSTS
Cytogenetic Map17q12.3UniSTS
BI294581  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21782,256,750 - 82,256,903 (+)MAPPERmRatBN7.2
Rnor_6.01786,404,651 - 86,404,803NCBIRnor6.0
Rnor_5.01788,114,471 - 88,114,623UniSTSRnor5.0
RGSC_v3.41793,703,999 - 93,704,151UniSTSRGSC3.4
Celera1781,528,142 - 81,528,294UniSTS
RH 3.4 Map17836.1UniSTS
Cytogenetic Map17q12.3UniSTS
RH135024  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21782,262,382 - 82,262,585 (+)MAPPERmRatBN7.2
Rnor_6.01786,410,283 - 86,410,485NCBIRnor6.0
Rnor_5.01788,120,103 - 88,120,305UniSTSRnor5.0
RGSC_v3.41793,709,631 - 93,709,833UniSTSRGSC3.4
Celera1781,533,680 - 81,533,882UniSTS
RH 3.4 Map17836.4UniSTS
Cytogenetic Map17q12.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 14 1 7 3 11
Low 3 29 57 41 19 41 8 10 67 35 38 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000022734   ⟹   ENSRNOP00000060310
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1782,259,840 - 82,262,995 (+)Ensembl
Rnor_6.0 Ensembl1786,408,151 - 86,409,518 (+)Ensembl
RefSeq Acc Id: NM_001400772   ⟹   NP_001387701
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81787,168,248 - 87,171,098 (+)NCBI
mRatBN7.21782,259,920 - 82,262,770 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001387701 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000060310
  ENSRNOP00000060310.1
RefSeq Acc Id: ENSRNOP00000060310   ⟸   ENSRNOT00000022734
RefSeq Acc Id: NP_001387701   ⟸   NM_001400772
- UniProtKB: D3ZNC0 (UniProtKB/TrEMBL)
Protein Domains
OTU

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZNC0-F1-model_v2 AlphaFold D3ZNC0 1-455 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700611
Promoter ID:EPDNEW_R11132
Type:single initiation site
Name:Otud1_1
Description:OTU deubiquitinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01786,408,153 - 86,408,213EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563344 AgrOrtholog
BioCyc Gene G2FUF-8526 BioCyc
Ensembl Genes ENSRNOG00000016950 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022734 ENTREZGENE
  ENSRNOT00000022734.6 UniProtKB/TrEMBL
Gene3D-CATH 3.90.70.80 UniProtKB/TrEMBL
InterPro OTU UniProtKB/TrEMBL
  OTUD1_OTU UniProtKB/TrEMBL
  Papain_like_cys_pep_sf UniProtKB/TrEMBL
KEGG Report rno:498803 UniProtKB/TrEMBL
NCBI Gene 498803 ENTREZGENE
PANTHER OTU DOMAIN CONTAINING PROTEIN UniProtKB/TrEMBL
  OTU DOMAIN-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
Pfam OTU UniProtKB/TrEMBL
PhenoGen Otud1 PhenoGen
PROSITE OTU UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016950 RatGTEx
Superfamily-SCOP SSF54001 UniProtKB/TrEMBL
UniProt D3ZNC0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-13 Otud1  OTU deubiquitinase 1  Otud1  OTU domain containing 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Otud1  OTU domain containing 1  RGD1563344_predicted  similar to OTU domain containing 1 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1563344_predicted  similar to OTU domain containing 1 (predicted)  LOC498803  similar to OTU domain containing 1  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498803  similar to OTU domain containing 1      Symbol and Name status set to provisional 70820 PROVISIONAL