Usp51 (ubiquitin specific peptidase 51) - Rat Genome Database

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Gene: Usp51 (ubiquitin specific peptidase 51) Rattus norvegicus
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Symbol: Usp51
Name: ubiquitin specific peptidase 51
RGD ID: 1562211
Description: Predicted to enable chromatin binding activity; deubiquitinase activity; and histone binding activity. Predicted to be involved in DNA repair-dependent chromatin remodeling; regulation of cell cycle process; and regulation of double-strand break repair. Orthologous to human USP51 (ubiquitin specific peptidase 51); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC317398; LOC317398; RGD1562211; similar to ubiquitin specific protease 51; ubiquitin carboxyl-terminal hydrolase 51; ubiquitin specific protease 51
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X21,750,630 - 21,757,163 (-)NCBIGRCr8
mRatBN7.2X18,374,940 - 18,381,472 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX18,376,930 - 18,379,888 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX15,779,131 - 15,782,177 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X24,342,778 - 24,345,824 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X18,838,203 - 18,841,250 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X19,268,352 - 19,273,753 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX19,270,181 - 19,273,139 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X20,034,328 - 20,039,458 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X38,541,807 - 38,544,854 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX18,650,454 - 18,653,501 (-)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14715245   PMID:27083998  


Genomics

Comparative Map Data
Usp51
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X21,750,630 - 21,757,163 (-)NCBIGRCr8
mRatBN7.2X18,374,940 - 18,381,472 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX18,376,930 - 18,379,888 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX15,779,131 - 15,782,177 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X24,342,778 - 24,345,824 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X18,838,203 - 18,841,250 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X19,268,352 - 19,273,753 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX19,270,181 - 19,273,139 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X20,034,328 - 20,039,458 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X38,541,807 - 38,544,854 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX18,650,454 - 18,653,501 (-)NCBICelera
Cytogenetic MapXq12NCBI
USP51
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X55,484,616 - 55,489,848 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX55,484,616 - 55,489,848 (-)EnsemblGRCh38hg38GRCh38
GRCh37X55,511,049 - 55,516,281 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X55,529,687 - 55,532,356 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX59,350,733 - 59,355,315 (-)NCBICelera
Cytogenetic MapXp11.21NCBI
HuRefX52,562,965 - 52,563,571 (-)NCBIHuRef
CHM1_1X55,501,196 - 55,505,789 (-)NCBICHM1_1
T2T-CHM13v2.0X54,776,519 - 54,781,751 (+)NCBIT2T-CHM13v2.0
Usp51
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X151,789,433 - 151,794,360 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX151,789,465 - 151,792,412 (+)EnsemblGRCm39 Ensembl
GRCm38X153,006,469 - 153,011,364 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX153,006,469 - 153,009,416 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X149,441,012 - 149,444,004 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X148,349,229 - 148,350,113 (+)NCBIMGSCv36mm8
CeleraX136,241,129 - 136,244,306 (-)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX68.46NCBI
USP51
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X56,913,201 - 56,918,775 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X56,916,807 - 56,922,382 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X47,747,547 - 47,753,119 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
USP51
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X47,055,226 - 47,059,552 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX38,292,359 - 38,295,093 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X47,362,810 - 47,365,543 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X46,666,562 - 46,669,293 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X47,287,285 - 47,289,981 (+)NCBIUNSW_CanFamBas_1.0
Usp51
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X39,915,334 - 39,919,137 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368191,116,447 - 1,118,558 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049368191,115,524 - 1,119,083 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
USP51
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX48,048,223 - 48,050,355 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X48,047,658 - 48,051,941 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X54,046,247 - 54,050,090 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103232044
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X51,539,955 - 51,545,552 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX51,542,091 - 51,544,223 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236667123,047 - 8,957 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Usp51
5 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:6
Count of miRNA genes:5
Interacting mature miRNAs:6
Transcripts:ENSRNOT00000029397
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3
Low 10 9 6 6 74 18 35
Below cutoff 1 18 16 11 8 11 3 3 15 3 10 3

Sequence


RefSeq Acc Id: ENSRNOT00000029397   ⟹   ENSRNOP00000032575
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX18,376,930 - 18,379,888 (-)Ensembl
Rnor_6.0 EnsemblX19,270,181 - 19,273,139 (+)Ensembl
RefSeq Acc Id: NM_001108252   ⟹   NP_001101722
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X21,752,531 - 21,755,578 (-)NCBI
mRatBN7.2X18,376,841 - 18,379,888 (-)NCBI
Rnor_6.0X19,270,181 - 19,273,228 (+)NCBI
Rnor_5.0X20,034,328 - 20,039,458 (+)NCBI
RGSC_v3.4X38,541,807 - 38,544,854 (+)RGD
CeleraX18,650,454 - 18,653,501 (-)RGD
Sequence:
RefSeq Acc Id: XM_006256768   ⟹   XP_006256830
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X21,750,630 - 21,757,163 (-)NCBI
mRatBN7.2X18,374,940 - 18,381,472 (-)NCBI
Rnor_6.0X19,268,352 - 19,273,753 (+)NCBI
Rnor_5.0X20,034,328 - 20,039,458 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039099797   ⟹   XP_038955725
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X21,750,630 - 21,757,131 (-)NCBI
mRatBN7.2X18,374,940 - 18,381,448 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001101722 (Get FASTA)   NCBI Sequence Viewer  
  XP_006256830 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955725 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL86355 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000032575
  ENSRNOP00000032575.4
RefSeq Acc Id: NP_001101722   ⟸   NM_001108252
- UniProtKB: D3ZUR6 (UniProtKB/TrEMBL),   A6KL64 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256830   ⟸   XM_006256768
- Peptide Label: isoform X1
- UniProtKB: D3ZUR6 (UniProtKB/TrEMBL),   A6KL64 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000032575   ⟸   ENSRNOT00000029397
RefSeq Acc Id: XP_038955725   ⟸   XM_039099797
- Peptide Label: isoform X1
- UniProtKB: D3ZUR6 (UniProtKB/TrEMBL),   A6KL64 (UniProtKB/TrEMBL)
Protein Domains
UBP-type   USP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZUR6-F1-model_v2 AlphaFold D3ZUR6 1-696 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562211 AgrOrtholog
BioCyc Gene G2FUF-2826 BioCyc
Ensembl Genes ENSRNOG00000021434 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000029397 ENTREZGENE
  ENSRNOT00000029397.7 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
  Cysteine proteinases UniProtKB/TrEMBL
InterPro Papain_like_cys_pep_sf UniProtKB/TrEMBL
  Pept_C19ubi-hydrolase_C_CS UniProtKB/TrEMBL
  Peptidase_C19 UniProtKB/TrEMBL
  UCH/PAN2 UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_UBP UniProtKB/TrEMBL
KEGG Report rno:317398 UniProtKB/TrEMBL
NCBI Gene 317398 ENTREZGENE
PANTHER PTHR21646:SF38 UniProtKB/TrEMBL
  UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UniProtKB/TrEMBL
Pfam UCH UniProtKB/TrEMBL
  zf-UBP UniProtKB/TrEMBL
PhenoGen Usp51 PhenoGen
PROSITE UCH_2_1 UniProtKB/TrEMBL
  UCH_2_2 UniProtKB/TrEMBL
  UCH_2_3 UniProtKB/TrEMBL
  ZF_UBP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021434 RatGTEx
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
  SSF54001 UniProtKB/TrEMBL
UniProt A6KL64 ENTREZGENE, UniProtKB/TrEMBL
  D3ZUR6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-06-13 Usp51  ubiquitin specific peptidase 51  Usp51  ubiquitin specific protease 51  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-05-26 Usp51  ubiquitin specific protease 51  RGD1562211  similar to ubiquitin specific protease 51  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1562211  similar to ubiquitin specific protease 51   RGD1562211_predicted  similar to ubiquitin specific protease 51 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1562211_predicted  similar to ubiquitin specific protease 51 (predicted)  LOC317398  similar to ubiquitin specific protease 51  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC317398  similar to ubiquitin specific protease 51      Symbol and Name status set to provisional 70820 PROVISIONAL