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Gene: Otud6a (OTU deubiquitinase 6A) Rattus norvegicus

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Symbol:

Otud6a

Name:

OTU deubiquitinase 6A

RGD ID:

1560855

Description:

Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in protein deubiquitination. Orthologous to human OTUD6A (OTU deubiquitinase 6A); INTERACTS WITH Cuprizon; all-trans-retinoic acid (ortholog); benzo[a]pyrene (ortholog).

Type:

protein-coding

RefSeq Status:

INFERRED

Previously known as:

LOC302426; OTU domain containing 6A; OTU domain-containing protein 6A; RGD1560855; similar to Hin-6 protease

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	OTUD6A (OTU deubiquitinase 6A)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Otud6a (OTU domain containing 6A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Otud6a (OTU deubiquitinase 6A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	OTUD6A (OTU deubiquitinase 6A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	OTUD6A (OTU deubiquitinase 6A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Otud6a (OTU deubiquitinase 6A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	OTUD6A (OTU deubiquitinase 6A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	OTUD6A (OTU deubiquitinase 6A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Otud6a (OTU deubiquitinase 6A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	OTUD6A (OTU deubiquitinase 6A)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Otud6a (OTU domain containing 6A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	otud6b (OTU domain containing 6B)	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	OTU2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG7857	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	otub-3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	otud6b	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	69,554,215 - 69,556,389 (+)	NCBI		GRCr8
mRatBN7.2	X	65,514,113 - 65,516,287 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	65,514,191 - 65,515,063 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	66,997,545 - 66,999,719 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	70,497,935 - 70,500,109 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	68,058,827 - 68,061,001 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	70,256,299 - 70,257,746 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	70,256,737 - 70,257,609 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	71,129,608 - 71,130,752 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	88,427,849 - 88,428,721 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	65,874,546 - 65,875,993 (+)	NCBI		Celera
Cytogenetic Map	X	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Otud6a	Rat	autistic disorder		ISO	OTUD6A (Homo sapiens)	8554872	ClinVar Annotator: match by term: Autism	ClinVar	PMID:21681106 and PMID:30208311
Otud6a	Rat	autosomal hemophilia A		ISO	OTUD6A (Homo sapiens)	8554872	ClinVar Annotator: match by term: AUTOSOMAL HEMOPHILIA A	ClinVar	PMID:31690835
Otud6a	Rat	factor VIII deficiency		ISO	OTUD6A (Homo sapiens)	8554872	ClinVar Annotator: match by term: Factor 8 deficiency and congenital	ClinVar	PMID:31690835
Otud6a	Rat	syndromic X-linked intellectual disability Lubs type		ISO	OTUD6A (Homo sapiens)	8554872	ClinVar Annotator: match by term: Syndromic X-linked intellectual disability Lubs type	ClinVar	PMID:25741868

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Otud6a	Rat	all-trans-retinoic acid	multiple interactions	ISO	Otud6a (Mus musculus)	6480464	[mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in increased expression of OTUD6A mRNA	CTD	PMID:36189433
Otud6a	Rat	all-trans-retinoic acid	increases expression	ISO	Otud6a (Mus musculus)	6480464	Tretinoin results in increased expression of OTUD6A mRNA	CTD	PMID:36189433
Otud6a	Rat	benzo[a]pyrene	affects methylation	ISO	OTUD6A (Homo sapiens)	6480464	Benzo(a)pyrene affects the methylation of OTUD6A exon and Benzo(a)pyrene affects the methylation of OTUD6A promoter	CTD	PMID:27901495
Otud6a	Rat	bisphenol A	increases methylation	ISO	OTUD6A (Homo sapiens)	6480464	bisphenol A results in increased methylation of OTUD6A gene	CTD	PMID:31601247
Otud6a	Rat	Cuprizon	decreases expression	EXP		6480464	Cuprizone results in decreased expression of OTUD6A mRNA	CTD	PMID:27523638
Otud6a	Rat	folic acid	decreases expression	ISO	Otud6a (Mus musculus)	6480464	Folic Acid results in decreased expression of OTUD6A mRNA	CTD	PMID:25629700
Otud6a	Rat	mono(2-ethylhexyl) phthalate	multiple interactions	ISO	Otud6a (Mus musculus)	6480464	[mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in increased expression of OTUD6A mRNA	CTD	PMID:36189433
Otud6a	Rat	potassium dichromate	decreases expression	ISO	Otud6a (Mus musculus)	6480464	Potassium Dichromate results in decreased expression of OTUD6A mRNA	CTD	PMID:23608068
Otud6a	Rat	valproic acid	increases methylation	ISO	OTUD6A (Homo sapiens)	6480464	Valproic Acid results in increased methylation of OTUD6A gene	CTD	PMID:29154799

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Otud6a	Rat	protein K11-linked deubiquitination	involved_in	ISO	OTUD6A (Homo sapiens)	1624291	PMID:23827681	RGD	PMID:23827681
Otud6a	Rat	protein K11-linked deubiquitination	involved_in	IEA	UniProtKB:Q7L8S5 and ensembl:ENSP00000339389	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Otud6a	Rat	protein K27-linked deubiquitination	involved_in	ISO	OTUD6A (Homo sapiens)	1624291	PMID:23827681	RGD	PMID:23827681
Otud6a	Rat	protein K27-linked deubiquitination	involved_in	IEA	UniProtKB:Q7L8S5 and ensembl:ENSP00000339389	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Otud6a	Rat	protein K29-linked deubiquitination	involved_in	ISO	OTUD6A (Homo sapiens)	1624291	PMID:23827681	RGD	PMID:23827681
Otud6a	Rat	protein K29-linked deubiquitination	involved_in	IEA	UniProtKB:Q7L8S5 and ensembl:ENSP00000339389	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Otud6a	Rat	protein K33-linked deubiquitination	involved_in	ISO	OTUD6A (Homo sapiens)	1624291	PMID:23827681	RGD	PMID:23827681
Otud6a	Rat	protein K33-linked deubiquitination	involved_in	IEA	UniProtKB:Q7L8S5 and ensembl:ENSP00000339389	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Otud6a	Rat	cysteine-type deubiquitinase activity	enables	ISO	OTUD6A (Homo sapiens)	1624291	PMID:23827681	RGD	PMID:23827681
Otud6a	Rat	cysteine-type deubiquitinase activity	enables	IBA	FB:FBgn0026738 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Otud6a	Rat	cysteine-type deubiquitinase activity	enables	IEA	EC:3.4.19.12	1600115	GO_REF:0000003	UniProt	GO_REF:0000003
Otud6a	Rat	cysteine-type deubiquitinase activity	enables	IEA	UniProtKB:Q7L8S5 and ensembl:ENSP00000339389	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Otud6a	Rat	cysteine-type peptidase activity	enables	IEA	UniProtKB-KW:KW-0788	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Otud6a	Rat	protein binding	enables	ISO	OTUD6A (Homo sapiens)	1624291	UniProtKB:P12524-2 more ...	RGD	PMID:32296183

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

PMID:23827681

Otud6a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	69,554,215 - 69,556,389 (+)	NCBI		GRCr8
mRatBN7.2	X	65,514,113 - 65,516,287 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	65,514,191 - 65,515,063 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	66,997,545 - 66,999,719 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	70,497,935 - 70,500,109 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	68,058,827 - 68,061,001 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	70,256,299 - 70,257,746 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	70,256,737 - 70,257,609 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	71,129,608 - 71,130,752 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	88,427,849 - 88,428,721 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	65,874,546 - 65,875,993 (+)	NCBI		Celera
Cytogenetic Map	X	q22	NCBI

OTUD6A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	70,062,457 - 70,064,179 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	70,062,457 - 70,064,179 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	69,282,307 - 69,284,029 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	69,199,066 - 69,200,754 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	X	69,635,707 - 69,637,395 (+)	NCBI		Celera
Cytogenetic Map	X	q13.1	NCBI
HuRef	X	63,103,165 - 63,104,853 (+)	NCBI		HuRef
CHM1_1	X	69,175,955 - 69,177,643 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	68,495,808 - 68,497,530 (+)	NCBI		T2T-CHM13v2.0

Otud6a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	99,472,514 - 99,474,859 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	99,472,619 - 99,473,491 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	100,428,908 - 100,429,885 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	100,429,013 - 100,429,885 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	97,624,352 - 97,625,224 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	96,631,732 - 96,632,604 (+)	NCBI		MGSCv36	mm8
Celera	X	87,354,623 - 87,355,359 (+)	NCBI		Celera
Cytogenetic Map	X	C3	NCBI
cM Map	X	43.72	NCBI

Otud6a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955475	9,626,733 - 9,629,841 (+)	NCBI	ChiLan1.0	ChiLan1.0

OTUD6A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	69,738,016 - 69,743,091 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	69,741,619 - 69,746,694 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	59,331,364 - 59,333,978 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	69,393,964 - 69,394,910 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	69,394,044 - 69,394,910 (+)	Ensembl	panpan1.1		panPan2

OTUD6A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	54,546,016 - 54,548,379 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	54,546,123 - 54,546,983 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	45,372,133 - 45,374,509 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	55,512,419 - 55,514,795 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	55,512,544 - 55,513,404 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	53,481,460 - 53,483,839 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	54,812,259 - 54,814,635 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	54,739,422 - 54,741,798 (+)	NCBI		UU_Cfam_GSD_1.0

Otud6a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	47,616,949 - 47,618,324 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936777	1,616,038 - 1,616,913 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

OTUD6A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	56,134,853 - 56,135,722 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	56,134,479 - 56,137,096 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	63,332,231 - 63,333,313 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

OTUD6A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	59,889,957 - 59,893,168 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	59,890,630 - 59,891,496 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666065	1,753,324 - 1,754,885 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Otud6a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624903	27,196 - 28,465 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Otud6a
2 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	36
Count of miRNA genes:	36
Interacting mature miRNAs:	36
Transcripts:	ENSRNOT00000029298
Prediction methods:	Miranda, Pita, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61430	Cia18	Collagen induced arthritis QTL 18	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	14843113	120568734	Rat
738035	Stresp1	Stress response QTL 1	4.96	0.000011	stress-related behavior trait (VT:0010451)	defensive burying - coping	X	41304447	112935181	Rat
70221	Bp56	Blood pressure QTL 56	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	X	57042141	65612192	Rat
1598837	Memor13	Memory QTL 13	3.2		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	X	41052407	146860749	Rat

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
1	3	35	5	3	13	9	30	3	47	3


RefSeq Transcripts	NM_001401127	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_001069450	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000029298 ⟹ ENSRNOP00000037319

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	65,514,191 - 65,515,063 (+)	Ensembl
Rnor_6.0 Ensembl	X	70,256,737 - 70,257,609 (+)	Ensembl

RefSeq Acc Id:

NM_001401127 ⟹ NP_001388056

RefSeq Status:

INFERRED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	69,554,215 - 69,556,389 (+)	NCBI
mRatBN7.2	X	65,514,113 - 65,516,287 (+)	NCBI


Protein RefSeqs	NP_001388056	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000037319
	ENSRNOP00000037319.4

Ensembl Acc Id:

ENSRNOP00000037319 ⟸ ENSRNOT00000029298

RefSeq Acc Id:	NP_001388056 ⟸ NM_001401127
- UniProtKB:	D3ZX46 (UniProtKB/TrEMBL)

Protein Domains

OTU

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZX46-F1-model_v2	AlphaFold	D3ZX46	1-290	view protein structure

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-2135	BioCyc
Ensembl Genes	ENSRNOG00000042687	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000029298	ENTREZGENE
	ENSRNOT00000029298.5	UniProtKB/TrEMBL
Gene3D-CATH	3.90.70.80	UniProtKB/TrEMBL
InterPro	OTU	UniProtKB/TrEMBL
	OTU_OTUD6	UniProtKB/TrEMBL
	OTU_ubiquitin_thioesterase	UniProtKB/TrEMBL
	Papain_like_cys_pep_sf	UniProtKB/TrEMBL
NCBI Gene	302426	ENTREZGENE
PANTHER	OTU DOMAIN CONTAINING PROTEIN	UniProtKB/TrEMBL
	OTU DOMAIN-CONTAINING PROTEIN 6A	UniProtKB/TrEMBL
Pfam	OTU	UniProtKB/TrEMBL
PhenoGen	Otud6a	PhenoGen
PROSITE	OTU	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000042687	RatGTEx
Superfamily-SCOP	SSF54001	UniProtKB/TrEMBL
UniProt	D3ZX46	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2014-03-13	Otud6a	OTU deubiquitinase 6A	Otud6a	OTU domain containing 6A	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-28	Otud6a	OTU domain containing 6A	RGD1560855_predicted	similar to Hin-6 protease (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1560855_predicted	similar to Hin-6 protease (predicted)	LOC302426	similar to Hin-6 protease	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC302426	similar to Hin-6 protease			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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Imported Disease Annotations - ClinVar