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Gene: Usp38 (ubiquitin specific peptidase 38) Rattus norvegicus

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Symbol:

Usp38

Name:

ubiquitin specific peptidase 38

RGD ID:

1311974

Description:

Predicted to enable cysteine-type deubiquitinase activity and protein sequestering activity. Predicted to be involved in several processes, including negative regulation of innate immune response; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; and protein K33-linked deubiquitination. Predicted to be active in cytosol and nucleus. Orthologous to human USP38 (ubiquitin specific peptidase 38); INTERACTS WITH 17beta-estradiol; 2,6-dinitrotoluene; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC307764; ubiquitin carboxyl-terminal hydrolase 38; ubiquitin specific protease 38

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	43,910,459 - 43,941,875 (+)	NCBI		GRCr8
mRatBN7.2	19	27,006,046 - 27,037,449 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	27,006,046 - 27,037,437 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	33,859,775 - 33,891,219 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	34,513,838 - 34,545,280 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	36,738,942 - 36,770,306 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	30,668,258 - 30,699,852 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	30,668,602 - 30,699,859 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	41,576,070 - 41,607,659 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	28,847,283 - 28,879,605 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	28,852,729 - 28,883,368 (+)	NCBI
Celera	19	26,525,530 - 26,557,224 (+)	NCBI		Celera
Cytogenetic Map	19	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Usp38	Rat	1,2-dichloroethane	decreases expression	ISO	Usp38 (Mus musculus)	6480464	ethylene dichloride results in decreased expression of USP38 mRNA	CTD	PMID:28189721 and PMID:28960355
Usp38	Rat	1,2-dimethylhydrazine	affects expression	ISO	Usp38 (Mus musculus)	6480464	1 and 2-Dimethylhydrazine affects the expression of USP38 mRNA	CTD	PMID:22206623
Usp38	Rat	17beta-estradiol	increases expression	EXP		6480464	Estradiol results in increased expression of USP38 mRNA	CTD	PMID:32145629
Usp38	Rat	17beta-estradiol	decreases expression	ISO	Usp38 (Mus musculus)	6480464	Estradiol results in decreased expression of USP38 mRNA	CTD	PMID:39298647
Usp38	Rat	2,6-dinitrotoluene	affects expression	EXP		6480464	2 and 6-dinitrotoluene affects the expression of USP38 mRNA	CTD	PMID:21346803
Usp38	Rat	2-hydroxypropanoic acid	decreases expression	ISO	USP38 (Homo sapiens)	6480464	Lactic Acid results in decreased expression of USP38 mRNA	CTD	PMID:30851411
Usp38	Rat	2-palmitoylglycerol	increases expression	ISO	USP38 (Homo sapiens)	6480464	2-palmitoylglycerol results in increased expression of USP38 mRNA	CTD	PMID:37199045
Usp38	Rat	3,4-methylenedioxymethamphetamine	increases expression	ISO	Usp38 (Mus musculus)	6480464	N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of USP38 mRNA	CTD	PMID:20188158
Usp38	Rat	4,4'-sulfonyldiphenol	decreases expression	ISO	Usp38 (Mus musculus)	6480464	bisphenol S results in decreased expression of USP38 mRNA	CTD	PMID:39298647
Usp38	Rat	acrylamide	increases expression	ISO	USP38 (Homo sapiens)	6480464	Acrylamide results in increased expression of USP38 mRNA	CTD	PMID:32763439
Usp38	Rat	all-trans-retinoic acid	increases expression	ISO	USP38 (Homo sapiens)	6480464	Tretinoin results in increased expression of USP38 mRNA	CTD	PMID:33167477
Usp38	Rat	arsane	multiple interactions	ISO	USP38 (Homo sapiens)	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of USP38 mRNA	CTD	PMID:39836092
Usp38	Rat	arsenic atom	multiple interactions	ISO	USP38 (Homo sapiens)	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of USP38 mRNA	CTD	PMID:39836092
Usp38	Rat	atrazine	decreases expression	ISO	USP38 (Homo sapiens)	6480464	Atrazine results in decreased expression of USP38 mRNA	CTD	PMID:22378314
Usp38	Rat	benzo[a]pyrene	increases mutagenesis	ISO	USP38 (Homo sapiens)	6480464	Benzo(a)pyrene results in increased mutagenesis of USP38 gene	CTD	PMID:25435355
Usp38	Rat	benzo[a]pyrene	decreases methylation	ISO	USP38 (Homo sapiens)	6480464	Benzo(a)pyrene results in decreased methylation of USP38 promoter	CTD	PMID:27901495
Usp38	Rat	benzo[a]pyrene diol epoxide I	decreases expression	ISO	USP38 (Homo sapiens)	6480464	7 more ...	CTD	PMID:20018196
Usp38	Rat	bis(2-ethylhexyl) phthalate	increases expression	ISO	Usp38 (Mus musculus)	6480464	Diethylhexyl Phthalate results in increased expression of USP38 mRNA	CTD	PMID:21318169
Usp38	Rat	bisphenol A	increases expression	ISO	Usp38 (Mus musculus)	6480464	bisphenol A results in increased expression of USP38 mRNA	CTD	PMID:26063408
Usp38	Rat	bisphenol A	increases expression	EXP		6480464	bisphenol A results in increased expression of USP38 mRNA	CTD	PMID:30816183
Usp38	Rat	cadmium dichloride	increases expression	ISO	Usp38 (Mus musculus)	6480464	Cadmium Chloride results in increased expression of USP38 mRNA	CTD	PMID:20061341
Usp38	Rat	choline	multiple interactions	ISO	Usp38 (Mus musculus)	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of USP38 gene	CTD	PMID:20938992
Usp38	Rat	chromium(6+)	multiple interactions	ISO	USP38 (Homo sapiens)	6480464	[zinc chromate results in increased abundance of chromium hexavalent ion] which results in increased expression of USP38 mRNA	CTD	PMID:38479592
Usp38	Rat	ciguatoxin CTX1B	affects expression	ISO	Usp38 (Mus musculus)	6480464	Ciguatoxins affects the expression of USP38 mRNA	CTD	PMID:18353800
Usp38	Rat	cobalt dichloride	increases expression	ISO	USP38 (Homo sapiens)	6480464	cobaltous chloride results in increased expression of USP38 mRNA	CTD	PMID:19320972
Usp38	Rat	copper(II) sulfate	increases expression	ISO	USP38 (Homo sapiens)	6480464	Copper Sulfate results in increased expression of USP38 mRNA	CTD	PMID:19549813
Usp38	Rat	Dibutyl phosphate	affects expression	ISO	USP38 (Homo sapiens)	6480464	di-n-butylphosphoric acid affects the expression of USP38 mRNA	CTD	PMID:37042841
Usp38	Rat	fenofibrate	increases expression	ISO	Usp38 (Mus musculus)	6480464	Fenofibrate results in increased expression of USP38 mRNA	CTD	PMID:21318169
Usp38	Rat	fenofibrate	multiple interactions	ISO	Usp38 (Mus musculus)	6480464	PPARA protein affects the reaction [Fenofibrate results in increased expression of USP38 mRNA]	CTD	PMID:21318169
Usp38	Rat	folic acid	multiple interactions	ISO	Usp38 (Mus musculus)	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of USP38 gene	CTD	PMID:20938992
Usp38	Rat	folic acid	decreases expression	ISO	Usp38 (Mus musculus)	6480464	Folic Acid results in decreased expression of USP38 mRNA	CTD	PMID:25629700
Usp38	Rat	formaldehyde	decreases expression	ISO	USP38 (Homo sapiens)	6480464	Formaldehyde results in decreased expression of USP38 mRNA	CTD	PMID:20655997
Usp38	Rat	gentamycin	increases expression	EXP		6480464	Gentamicins results in increased expression of USP38 mRNA	CTD	PMID:33387578
Usp38	Rat	L-methionine	multiple interactions	ISO	Usp38 (Mus musculus)	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of USP38 gene	CTD	PMID:20938992
Usp38	Rat	leflunomide	increases expression	ISO	USP38 (Homo sapiens)	6480464	leflunomide results in increased expression of USP38 mRNA	CTD	PMID:28988120
Usp38	Rat	manganese atom	multiple interactions	ISO	USP38 (Homo sapiens)	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of USP38 mRNA	CTD	PMID:39836092
Usp38	Rat	manganese(0)	multiple interactions	ISO	USP38 (Homo sapiens)	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of USP38 mRNA	CTD	PMID:39836092
Usp38	Rat	manganese(II) chloride	multiple interactions	ISO	USP38 (Homo sapiens)	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of USP38 mRNA	CTD	PMID:39836092
Usp38	Rat	methylisothiazolinone	increases expression	ISO	USP38 (Homo sapiens)	6480464	2-methyl-4-isothiazolin-3-one results in increased expression of USP38 mRNA	CTD	PMID:31629900
Usp38	Rat	methylmercury chloride	increases expression	ISO	Usp38 (Mus musculus)	6480464	methylmercuric chloride results in increased expression of USP38 mRNA	CTD	PMID:20061341
Usp38	Rat	methylmercury chloride	decreases expression	ISO	USP38 (Homo sapiens)	6480464	methylmercuric chloride results in decreased expression of USP38 mRNA	CTD	PMID:28001369
Usp38	Rat	oxaliplatin	multiple interactions	EXP		6480464	[oxaliplatin co-treated with Topotecan] results in decreased expression of USP38 mRNA	CTD	PMID:25729387
Usp38	Rat	paracetamol	increases expression	EXP		6480464	Acetaminophen results in increased expression of USP38 mRNA	CTD	PMID:33387578
Usp38	Rat	perfluorooctane-1-sulfonic acid	decreases expression	ISO	USP38 (Homo sapiens)	6480464	perfluorooctane sulfonic acid results in decreased expression of USP38 mRNA	CTD	PMID:27153767
Usp38	Rat	pirinixic acid	increases expression	ISO	Usp38 (Mus musculus)	6480464	pirinixic acid results in increased expression of USP38 mRNA	CTD	PMID:18301758 and PMID:21318169
Usp38	Rat	pirinixic acid	multiple interactions	ISO	Usp38 (Mus musculus)	6480464	PPARA protein affects the reaction [pirinixic acid results in increased expression of USP38 mRNA]	CTD	PMID:21318169
Usp38	Rat	rac-lactic acid	decreases expression	ISO	USP38 (Homo sapiens)	6480464	Lactic Acid results in decreased expression of USP38 mRNA	CTD	PMID:30851411
Usp38	Rat	silver atom	decreases expression	ISO	Usp38 (Mus musculus)	6480464	Silver results in decreased expression of USP38 mRNA	CTD	PMID:27131904
Usp38	Rat	silver(0)	decreases expression	ISO	Usp38 (Mus musculus)	6480464	Silver results in decreased expression of USP38 mRNA	CTD	PMID:27131904
Usp38	Rat	sodium arsenite	affects methylation	ISO	USP38 (Homo sapiens)	6480464	sodium arsenite affects the methylation of USP38 gene	CTD	PMID:28589171
Usp38	Rat	sodium arsenite	multiple interactions	ISO	USP38 (Homo sapiens)	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of USP38 mRNA	CTD	PMID:39836092
Usp38	Rat	sodium arsenite	increases expression	ISO	USP38 (Homo sapiens)	6480464	sodium arsenite results in increased expression of USP38 mRNA	CTD	PMID:38568856
Usp38	Rat	Soman	increases expression	EXP		6480464	Soman results in increased expression of USP38 mRNA	CTD	PMID:19281266
Usp38	Rat	sunitinib	increases expression	ISO	USP38 (Homo sapiens)	6480464	Sunitinib results in increased expression of USP38 mRNA	CTD	PMID:31533062
Usp38	Rat	tetrachloromethane	decreases expression	EXP		6480464	Carbon Tetrachloride results in decreased expression of USP38 mRNA	CTD	PMID:30723492
Usp38	Rat	titanium dioxide	decreases methylation	ISO	Usp38 (Mus musculus)	6480464	titanium dioxide results in decreased methylation of USP38 promoter	CTD	PMID:35295148
Usp38	Rat	topotecan	multiple interactions	EXP		6480464	[oxaliplatin co-treated with Topotecan] results in decreased expression of USP38 mRNA	CTD	PMID:25729387
Usp38	Rat	trimellitic anhydride	increases expression	ISO	Usp38 (Mus musculus)	6480464	trimellitic anhydride results in increased expression of USP38 mRNA	CTD	PMID:19042947
Usp38	Rat	urethane	increases expression	ISO	USP38 (Homo sapiens)	6480464	Urethane results in increased expression of USP38 mRNA	CTD	PMID:28818685
Usp38	Rat	valproic acid	increases expression	ISO	USP38 (Homo sapiens)	6480464	Valproic Acid results in increased expression of USP38 mRNA	CTD	PMID:29154799
Usp38	Rat	valproic acid	decreases methylation	ISO	USP38 (Homo sapiens)	6480464	Valproic Acid results in decreased methylation of USP38 gene	CTD	PMID:29154799

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Usp38	Rat	negative regulation of innate immune response	involved_in	ISO	USP38 (Homo sapiens)	1624291	PMID:27692986	RGD	PMID:27692986
Usp38	Rat	negative regulation of innate immune response	involved_in	IEA	UniProtKB:Q8NB14 and ensembl:ENSP00000303434	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Usp38	Rat	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	involved_in	ISO	USP38 (Homo sapiens)	1624291	PMID:34102342	RGD	PMID:34102342
Usp38	Rat	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	involved_in	IEA	UniProtKB:Q8NB14 and ensembl:ENSP00000303434	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Usp38	Rat	protein deubiquitination	involved_in	IEA	InterPro:IPR001394	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Usp38	Rat	protein K33-linked deubiquitination	involved_in	ISO	USP38 (Homo sapiens)	1624291	PMID:27692986	RGD	PMID:27692986
Usp38	Rat	protein K33-linked deubiquitination	involved_in	IEA	UniProtKB:Q8NB14 and ensembl:ENSP00000303434	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Usp38	Rat	proteolysis	involved_in	IEA	UniProtKB-KW:KW-0645	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Usp38	Rat	regulation of protein stability	involved_in	IBA	FB:FBgn0016756 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Usp38	Rat	ubiquitin-dependent protein catabolic process	involved_in	IEA	InterPro:IPR033840	1600115	GO_REF:0000002	InterPro	GO_REF:0000002

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Usp38	Rat	cytoplasm	is_active_in	ISO	USP38 (Homo sapiens)	1624291	PMID:27692986	RGD	PMID:27692986
Usp38	Rat	cytoplasm	is_active_in	IEA	UniProtKB:Q8NB14 and ensembl:ENSP00000303434	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Usp38	Rat	cytosol	is_active_in	IBA	FB:FBgn0016756 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Usp38	Rat	nucleus	is_active_in	IBA	FB:FBgn0016756 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Usp38	Rat	cysteine-type deubiquitinase activity	enables	ISO	USP38 (Homo sapiens)	1624291	PMID:14715245 and PMID:27692986	RGD	PMID:14715245 and PMID:27692986
Usp38	Rat	cysteine-type deubiquitinase activity	enables	IEA	InterPro:IPR001394 and InterPro:IPR018200	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Usp38	Rat	cysteine-type deubiquitinase activity	enables	IEA	UniProtKB:Q8NB14 and ensembl:ENSP00000303434	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Usp38	Rat	cysteine-type deubiquitinase activity	enables	IBA	FB:FBgn0005632 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Usp38	Rat	cysteine-type peptidase activity	enables	IEA	UniProtKB-KW:KW-0788	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Usp38	Rat	hydrolase activity	enables	IEA	UniProtKB-KW:KW-0378	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Usp38	Rat	peptidase activity	enables	IEA	UniProtKB-KW:KW-0645	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Usp38	Rat	protein binding	enables	ISO	USP38 (Homo sapiens)	1624291	UniProtKB:P17252 more ...	RGD	PMID:32814053
Usp38	Rat	protein sequestering activity	enables	IEA	UniProtKB:Q8NB14 and ensembl:ENSP00000303434	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

PMID:14715245

Usp38
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	43,910,459 - 43,941,875 (+)	NCBI		GRCr8
mRatBN7.2	19	27,006,046 - 27,037,449 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	27,006,046 - 27,037,437 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	33,859,775 - 33,891,219 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	34,513,838 - 34,545,280 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	36,738,942 - 36,770,306 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	30,668,258 - 30,699,852 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	30,668,602 - 30,699,859 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	41,576,070 - 41,607,659 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	28,847,283 - 28,879,605 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	28,852,729 - 28,883,368 (+)	NCBI
Celera	19	26,525,530 - 26,557,224 (+)	NCBI		Celera
Cytogenetic Map	19	q11	NCBI

USP38
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	143,184,917 - 143,223,874 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	143,184,917 - 143,225,212 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	144,106,070 - 144,145,027 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	144,325,548 - 144,362,090 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	144,463,702 - 144,500,244	NCBI
Celera	4	141,435,984 - 141,473,049 (+)	NCBI		Celera
Cytogenetic Map	4	q31.21	NCBI
HuRef	4	139,835,778 - 139,872,846 (+)	NCBI		HuRef
CHM1_1	4	144,083,284 - 144,120,348 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	146,502,094 - 146,541,045 (+)	NCBI		T2T-CHM13v2.0

Usp38
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	81,707,353 - 81,741,631 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	81,707,362 - 81,741,557 (-)	Ensembl		GRCm39 Ensembl
GRCm38	8	80,980,724 - 81,015,013 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	80,980,733 - 81,014,928 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	83,504,632 - 83,538,805 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	83,876,479 - 83,910,652 (-)	NCBI		MGSCv36	mm8
Celera	8	85,259,181 - 85,286,557 (-)	NCBI		Celera
Celera	8	75,127,726 - 75,134,583 (+)	NCBI		Celera
Cytogenetic Map	8	C2	NCBI
cM Map	8	38.68	NCBI

Usp38
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955471	315,779 - 350,982 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955471	316,319 - 350,982 (-)	NCBI	ChiLan1.0	ChiLan1.0

USP38
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	141,060,691 - 141,106,019 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	141,448,446 - 141,493,761 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	135,545,818 - 135,582,520 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	146,844,850 - 146,881,486 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	146,844,850 - 146,881,486 (+)	Ensembl	panpan1.1		panPan2

USP38
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	19	201,810 - 238,361 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	19	210,388 - 238,384 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	19	450,450 - 488,291 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	19	225,088 - 262,681 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	19	233,599 - 262,766 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	19	204,694 - 242,742 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	19	565,325 - 603,796 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	19	919,303 - 957,368 (-)	NCBI		UU_Cfam_GSD_1.0

Usp38
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405301	47,708,507 - 47,740,441 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936535	5,146,327 - 5,178,205 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936535	5,146,327 - 5,178,184 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

USP38
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	84,567,618 - 84,601,224 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	84,567,476 - 84,601,044 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	89,716,675 - 89,724,274 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

USP38
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	90,049,643 - 90,087,152 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	90,049,638 - 90,089,110 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	69,649,470 - 69,688,113 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Usp38
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624853	2,485,332 - 2,518,070 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624853	2,485,347 - 2,519,165 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Usp38
118 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	73
Count of miRNA genes:	63
Interacting mature miRNAs:	67
Transcripts:	ENSRNOT00000035084
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1549847	Bss8	Bone structure and strength QTL 8	4		lumbar vertebra strength trait (VT:0010574)	vertebra ultimate force (CMO:0001678)	19	1	31963836	Rat
61447	Tcas1	Tongue tumor susceptibility QTL 1	6.08		tongue integrity trait (VT:0010553)	squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)	19	2316121	47316121	Rat
631681	Cm12	Cardiac mass QTL 12	3.33	0.00053	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	19	1	28982497	Rat
9590298	Uminl5	Urine mineral level QTL 5	3.59	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	19	1	36824771	Rat
1331737	Uae29	Urinary albumin excretion QTL 29	5.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	4096155	55283277	Rat
2298478	Eau8	Experimental allergic uveoretinitis QTL 8		0.0163	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	19	17154433	57337602	Rat
61328	Eae8	Experimental allergic encephalomyelitis QTL 8	4		nervous system integrity trait (VT:0010566)	percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)	19	24816041	33061905	Rat
1578764	Stresp19	Stress response QTL 19	3.6	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	19	15630201	57337602	Rat
1558656	Prcs1	Prostate cancer susceptibility QTL 1	5		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	19	15114598	34521833	Rat
9590090	Insglur8	Insulin/glucose ratio QTL 8	10.81	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	19	1	36824771	Rat
1331788	Rf45	Renal function QTL 45	2.818		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	19	15605023	46559041	Rat
1549835	Tcas7	Tongue tumor susceptibility QTL 7		0.001	tongue integrity trait (VT:0010553)	squamous cell carcinoma of the head and neck tumor number (CMO:0001876)	19	24817978	39654489	Rat
724566	Uae12	Urinary albumin excretion QTL 12	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	2187927	56457239	Rat
724565	Tcas5	Tongue tumor susceptibility QTL 5	10.04		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	19	9977753	39654489	Rat
61407	Scl12	Serum cholesterol level QTL 12		0.001	blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	19	13926401	30303727	Rat
8552935	Pigfal10	Plasma insulin-like growth factor 1 level QTL 10	5.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	19	1	36824771	Rat
61350	Bp32	Blood pressure QTL 32		0.012	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	19	20483575	57337602	Rat
7411549	Bw130	Body weight QTL 130	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	15455860	57337602	Rat
10054132	Srcrt9	Stress Responsive Cort QTL 9	2.87	0.0017	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	19	1	27355345	Rat
724518	Uae19	Urinary albumin excretion QTL 19	5.5		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	7457249	42983518	Rat
8694186	Bw152	Body weight QTL 152	3.34	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	569374	45569374	Rat
61423	Cia14	Collagen induced arthritis QTL 14	3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	19	10827970	43544039	Rat
631678	Cm9	Cardiac mass QTL 9	4.27	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	19	1	28982497	Rat
9590250	Scort11	Serum corticosterone level QTL 11	23.45	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	19	1	36824771	Rat
2317848	Alcrsp21	Alcohol response QTL 21	1.899999976158142	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	19	3204777	48204777	Rat
9589102	Slep13	Serum leptin concentration QTL 13	4.63	0.001	blood leptin amount (VT:0005667)	plasma leptin level (CMO:0000781)	19	569374	45569374	Rat
7247442	Uae39	Urinary albumin excretion QTL 39			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	2187927	46708701	Rat

D19Rat48

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	27,021,131 - 27,021,310 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	30,683,540 - 30,683,718	NCBI	Rnor6.0
Rnor_5.0	19	41,591,347 - 41,591,525	UniSTS	Rnor5.0
RGSC_v3.4	19	28,863,284 - 28,863,794	RGD	RGSC3.4
RGSC_v3.4	19	28,863,299 - 28,863,477	UniSTS	RGSC3.4
RGSC_v3.1	19	28,868,110 - 28,868,620	RGD
Celera	19	26,540,915 - 26,541,093	UniSTS
SHRSP x BN Map	19	20.2998	RGD
SHRSP x BN Map	19	20.2998	UniSTS
Cytogenetic Map	19	q11	UniSTS

RH134797

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	27,036,940 - 27,037,127 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	30,699,353 - 30,699,539	NCBI	Rnor6.0
Rnor_5.0	19	41,607,160 - 41,607,346	UniSTS	Rnor5.0
RGSC_v3.4	19	28,879,109 - 28,879,295	UniSTS	RGSC3.4
Celera	19	26,556,725 - 26,556,911	UniSTS
Cytogenetic Map	19	q11	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31


RefSeq Transcripts	NM_001107418	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_003751862	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_003753096	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097727	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097728	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063278019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005496654	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AI112444	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473972	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000035084 ⟹ ENSRNOP00000031071

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	27,006,046 - 27,037,437 (+)	Ensembl
Rnor_6.0 Ensembl	19	30,668,602 - 30,699,859 (+)	Ensembl

RefSeq Acc Id:

NM_001107418 ⟹ NP_001100888

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	43,910,474 - 43,941,869 (+)	NCBI
mRatBN7.2	19	27,006,046 - 27,037,440 (+)	NCBI

RefSeq Acc Id:

XM_039097727 ⟹ XP_038953655

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	43,929,791 - 43,941,875 (+)	NCBI
mRatBN7.2	19	27,027,586 - 27,037,449 (+)	NCBI

RefSeq Acc Id:

XM_039097728 ⟹ XP_038953656

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	43,910,461 - 43,937,004 (+)	NCBI
mRatBN7.2	19	27,006,046 - 27,032,575 (+)	NCBI

RefSeq Acc Id:

XM_063278019 ⟹ XP_063134089

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	43,915,302 - 43,941,875 (+)	NCBI

RefSeq Acc Id:

XR_005496654

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	43,910,459 - 43,933,579 (+)	NCBI
mRatBN7.2	19	27,006,046 - 27,029,150 (+)	NCBI


Protein RefSeqs	NP_001100888	(Get FASTA)	NCBI Sequence Viewer
	XP_038953655	(Get FASTA)	NCBI Sequence Viewer
	XP_038953656	(Get FASTA)	NCBI Sequence Viewer
	XP_063134089	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL92296	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000031071
	ENSRNOP00000031071.4

Ensembl Acc Id:

ENSRNOP00000031071 ⟸ ENSRNOT00000035084

RefSeq Acc Id:	NP_001100888 ⟸ NM_001107418
- UniProtKB:	D3Z8K5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038953656 ⟸ XM_039097728
- Peptide Label:	isoform X3
- UniProtKB:	A6IYG8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038953655 ⟸ XM_039097727
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063134089 ⟸ XM_063278019
- Peptide Label:	isoform X1

Protein Domains

USP

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3Z8K5-F1-model_v2	AlphaFold	D3Z8K5	1-1041	view protein structure

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-5980	BioCyc
Ensembl Genes	ENSRNOG00000026880	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000035084	ENTREZGENE
	ENSRNOT00000035084.7	UniProtKB/TrEMBL
Gene3D-CATH	Cysteine proteinases	UniProtKB/TrEMBL
InterPro	ARM-type_fold	UniProtKB/TrEMBL
	Papain_like_cys_pep_sf	UniProtKB/TrEMBL
	Pept_C19ubi-hydrolase_C_CS	UniProtKB/TrEMBL
	Peptidase_C19	UniProtKB/TrEMBL
	Peptidase_C19	UniProtKB/TrEMBL
	UCH/PAN2	UniProtKB/TrEMBL
	USP38	UniProtKB/TrEMBL
	Usp38-like_N	UniProtKB/TrEMBL
NCBI Gene	307764	ENTREZGENE
PANTHER	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE	UniProtKB/TrEMBL
	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 38	UniProtKB/TrEMBL
Pfam	UCH	UniProtKB/TrEMBL
	Usp38-like_N	UniProtKB/TrEMBL
PhenoGen	Usp38	PhenoGen
PROSITE	UCH_2_1	UniProtKB/TrEMBL
	UCH_2_2	UniProtKB/TrEMBL
	UCH_2_3	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000026880	RatGTEx
Superfamily-SCOP	ARM repeat	UniProtKB/TrEMBL
	SSF54001	UniProtKB/TrEMBL
UniProt	A6IYG8	ENTREZGENE, UniProtKB/TrEMBL
	D3Z8K5	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-04	Usp38	ubiquitin specific peptidase 38	Usp38_predicted	ubiquitin specific protease 38 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-12	Usp38_predicted	ubiquitin specific protease 38 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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