Usp28 (ubiquitin specific peptidase 28) - Rat Genome Database

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Gene: Usp28 (ubiquitin specific peptidase 28) Rattus norvegicus
Analyze
Symbol: Usp28
Name: ubiquitin specific peptidase 28
RGD ID: 1311555
Description: Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in several processes, including cellular response to UV; intracellular signal transduction; and response to ionizing radiation. Predicted to be located in nuclear body. Predicted to be part of protein-containing complex. Predicted to be active in cytosol and nucleus. Orthologous to human USP28 (ubiquitin specific peptidase 28); INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; 3-hydroxyisovaleric acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: deubiquitinating enzyme; deubiquitinating enzyme 28; LOC315639; ubiquitin carboxyl-terminal hydrolase 28; ubiquitin specific protease 28; ubiquitin thioesterase 28; ubiquitin thiolesterase 28; ubiquitin-specific-processing protease 28
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8858,222,258 - 58,282,711 (+)NCBIGRCr8
mRatBN7.2849,325,766 - 49,386,229 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl849,325,867 - 49,386,229 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx854,831,791 - 54,892,095 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0853,110,659 - 53,170,968 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0850,974,908 - 51,035,219 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0853,295,188 - 53,355,572 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl853,295,222 - 53,355,572 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0851,909,256 - 51,969,623 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4852,245,642 - 52,305,922 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1852,280,014 - 52,324,051 (+)NCBI
Celera848,883,162 - 48,943,411 (+)NCBICelera
Cytogenetic Map8q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA,IEA)
nuclear body  (ISO)
nucleoplasm  (ISO,ISS)
nucleus  (IBA,IEA)
protein-containing complex  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16901786   PMID:17558397   PMID:17873522   PMID:18662541   PMID:24623306   PMID:30149918  


Genomics

Comparative Map Data
Usp28
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8858,222,258 - 58,282,711 (+)NCBIGRCr8
mRatBN7.2849,325,766 - 49,386,229 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl849,325,867 - 49,386,229 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx854,831,791 - 54,892,095 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0853,110,659 - 53,170,968 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0850,974,908 - 51,035,219 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0853,295,188 - 53,355,572 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl853,295,222 - 53,355,572 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0851,909,256 - 51,969,623 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4852,245,642 - 52,305,922 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1852,280,014 - 52,324,051 (+)NCBI
Celera848,883,162 - 48,943,411 (+)NCBICelera
Cytogenetic Map8q23NCBI
USP28
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811113,797,875 - 113,875,572 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11113,797,874 - 113,875,572 (-)EnsemblGRCh38hg38GRCh38
GRCh3711113,668,597 - 113,746,294 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611113,173,807 - 113,251,466 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411113,173,807 - 113,251,466NCBI
Celera11110,821,475 - 110,899,132 (-)NCBICelera
Cytogenetic Map11q23.2NCBI
HuRef11109,597,124 - 109,674,696 (-)NCBIHuRef
CHM1_111113,551,888 - 113,629,830 (-)NCBICHM1_1
T2T-CHM13v2.011113,808,211 - 113,885,899 (-)NCBIT2T-CHM13v2.0
Usp28
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39948,896,577 - 48,953,817 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl948,896,675 - 48,953,817 (+)EnsemblGRCm39 Ensembl
GRCm38948,985,319 - 49,042,517 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl948,985,375 - 49,042,517 (+)EnsemblGRCm38mm10GRCm38
MGSCv37948,793,490 - 48,850,622 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36948,737,317 - 48,794,449 (+)NCBIMGSCv36mm8
Celera946,282,655 - 46,339,797 (+)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map926.56NCBI
Usp28
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541215,426,159 - 15,443,023 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541215,425,136 - 15,469,819 (-)NCBIChiLan1.0ChiLan1.0
USP28
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29114,541,035 - 114,618,841 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111115,635,396 - 115,713,169 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011108,676,566 - 108,754,372 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111112,519,147 - 112,595,076 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11112,517,693 - 112,595,585 (-)Ensemblpanpan1.1panPan2
USP28
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1519,431,313 - 19,480,709 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl519,435,451 - 19,479,640 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha519,338,576 - 19,404,153 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0519,435,675 - 19,501,359 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl519,437,389 - 19,501,355 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1519,499,600 - 19,565,243 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0519,400,925 - 19,465,977 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0519,448,052 - 19,514,120 (+)NCBIUU_Cfam_GSD_1.0
Usp28
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494795,900,690 - 95,962,848 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936612742,725 - 804,921 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936612742,777 - 804,919 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
USP28
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl941,417,564 - 41,480,994 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1941,417,560 - 41,481,044 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2946,178,504 - 46,217,852 (-)NCBISscrofa10.2Sscrofa10.2susScr3
USP28
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11105,175,116 - 105,257,163 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1105,175,067 - 105,257,102 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604320,764,288 - 20,844,351 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Usp28
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247849,303,745 - 9,378,105 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247849,302,741 - 9,352,127 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Usp28
129 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:244
Count of miRNA genes:90
Interacting mature miRNAs:110
Transcripts:ENSRNOT00000009724, ENSRNOT00000067420
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)82824291253961020Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82950266550095447Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
5684993Bmd84Bone mineral density QTL 844.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)84269268450095447Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat

Markers in Region
BF413316  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2849,381,722 - 49,381,816 (+)MAPPERmRatBN7.2
Rnor_6.0853,351,067 - 53,351,160NCBIRnor6.0
Rnor_5.0851,965,118 - 51,965,211UniSTSRnor5.0
RGSC_v3.4852,301,417 - 52,301,510UniSTSRGSC3.4
Celera848,938,906 - 48,938,999UniSTS
RH 3.4 Map8524.0UniSTS
Cytogenetic Map8q23UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 43 20 6 19 6 8 11 74 22 38 11 8
Low 1 37 35 35 13 3
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001108144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039081444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039081445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB240643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC097700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000009724   ⟹   ENSRNOP00000009724
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl849,340,687 - 49,386,229 (+)Ensembl
Rnor_6.0 Ensembl853,295,222 - 53,355,323 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000067420   ⟹   ENSRNOP00000060005
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl849,325,937 - 49,386,229 (+)Ensembl
Rnor_6.0 Ensembl853,295,292 - 53,355,572 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099397   ⟹   ENSRNOP00000090131
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl849,325,937 - 49,386,229 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102592   ⟹   ENSRNOP00000091262
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl849,325,867 - 49,386,229 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119039   ⟹   ENSRNOP00000083392
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl849,325,937 - 49,386,229 (+)Ensembl
RefSeq Acc Id: NM_001108144   ⟹   NP_001101614
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8858,222,429 - 58,282,711 (+)NCBI
mRatBN7.2849,325,937 - 49,386,229 (+)NCBI
Rnor_6.0853,295,292 - 53,355,572 (+)NCBI
Rnor_5.0851,909,256 - 51,969,623 (+)NCBI
RGSC_v3.4852,245,642 - 52,305,922 (+)RGD
Celera848,883,162 - 48,943,411 (+)RGD
Sequence:
RefSeq Acc Id: XM_006243006   ⟹   XP_006243068
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8858,222,289 - 58,282,700 (+)NCBI
mRatBN7.2849,325,766 - 49,386,223 (+)NCBI
Rnor_6.0853,295,188 - 53,355,563 (+)NCBI
Rnor_5.0851,909,256 - 51,969,623 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243007   ⟹   XP_006243069
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8858,222,289 - 58,282,700 (+)NCBI
mRatBN7.2849,325,828 - 49,386,223 (+)NCBI
Rnor_6.0853,295,188 - 53,355,563 (+)NCBI
Rnor_5.0851,909,256 - 51,969,623 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243008   ⟹   XP_006243070
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8858,222,289 - 58,282,700 (+)NCBI
mRatBN7.2849,325,766 - 49,386,223 (+)NCBI
Rnor_6.0853,295,188 - 53,355,563 (+)NCBI
Rnor_5.0851,909,256 - 51,969,623 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243009   ⟹   XP_006243071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8858,222,289 - 58,282,700 (+)NCBI
mRatBN7.2849,325,766 - 49,386,223 (+)NCBI
Rnor_6.0853,295,188 - 53,355,563 (+)NCBI
Rnor_5.0851,909,256 - 51,969,623 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243010   ⟹   XP_006243072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8858,222,289 - 58,282,700 (+)NCBI
mRatBN7.2849,325,828 - 49,386,223 (+)NCBI
Rnor_6.0853,295,188 - 53,355,563 (+)NCBI
Rnor_5.0851,909,256 - 51,969,623 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243011   ⟹   XP_006243073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8858,222,258 - 58,282,700 (+)NCBI
mRatBN7.2849,325,766 - 49,386,223 (+)NCBI
Rnor_6.0853,295,188 - 53,355,563 (+)NCBI
Rnor_5.0851,909,256 - 51,969,623 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243012   ⟹   XP_006243074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8858,222,289 - 58,282,700 (+)NCBI
mRatBN7.2849,325,829 - 49,386,223 (+)NCBI
Rnor_6.0853,295,188 - 53,355,563 (+)NCBI
Rnor_5.0851,909,256 - 51,969,623 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039081444   ⟹   XP_038937372
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8858,222,289 - 58,274,578 (+)NCBI
mRatBN7.2849,325,766 - 49,378,148 (+)NCBI
RefSeq Acc Id: XM_039081445   ⟹   XP_038937373
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8858,254,864 - 58,282,700 (+)NCBI
mRatBN7.2849,358,382 - 49,386,223 (+)NCBI
RefSeq Acc Id: XM_063265441   ⟹   XP_063121511
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8858,222,289 - 58,282,700 (+)NCBI
RefSeq Acc Id: XM_063265442   ⟹   XP_063121512
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8858,222,289 - 58,282,700 (+)NCBI
RefSeq Acc Id: XM_063265443   ⟹   XP_063121513
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8858,254,867 - 58,282,700 (+)NCBI
RefSeq Acc Id: NP_001101614   ⟸   NM_001108144
- UniProtKB: A0A0H2UI12 (UniProtKB/TrEMBL),   A0A8I6AFT3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243071   ⟸   XM_006243009
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A8Q3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243068   ⟸   XM_006243006
- Peptide Label: isoform X1
- UniProtKB: A0A140TAA0 (UniProtKB/TrEMBL),   A0A8I5ZWX4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243069   ⟸   XM_006243007
- Peptide Label: isoform X2
- UniProtKB: A0A140TAA0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243070   ⟸   XM_006243008
- Peptide Label: isoform X3
- UniProtKB: D2Y8W6 (UniProtKB/Swiss-Prot),   D3ZJ96 (UniProtKB/Swiss-Prot),   A0A8I6AFT3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243072   ⟸   XM_006243010
- Peptide Label: isoform X5
- UniProtKB: A0A8I6AFT3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243074   ⟸   XM_006243012
- Peptide Label: isoform X7
- UniProtKB: A0A8I6AFT3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243073   ⟸   XM_006243011
- Peptide Label: isoform X6
- UniProtKB: A0A8I6AFT3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000060005   ⟸   ENSRNOT00000067420
RefSeq Acc Id: ENSRNOP00000009724   ⟸   ENSRNOT00000009724
RefSeq Acc Id: XP_038937372   ⟸   XM_039081444
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038937373   ⟸   XM_039081445
- Peptide Label: isoform X11
RefSeq Acc Id: ENSRNOP00000091262   ⟸   ENSRNOT00000102592
RefSeq Acc Id: ENSRNOP00000083392   ⟸   ENSRNOT00000119039
RefSeq Acc Id: ENSRNOP00000090131   ⟸   ENSRNOT00000099397
RefSeq Acc Id: XP_063121511   ⟸   XM_063265441
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063121512   ⟸   XM_063265442
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063121513   ⟸   XM_063265443
- Peptide Label: isoform X12
Protein Domains
UIM   USP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZJ96-F1-model_v2 AlphaFold D3ZJ96 1-1083 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695958
Promoter ID:EPDNEW_R6464
Type:initiation region
Name:Usp28_1
Description:ubiquitin specific peptidase 28
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0853,295,191 - 53,295,251EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311555 AgrOrtholog
BioCyc Gene G2FUF-30590 BioCyc
Ensembl Genes ENSRNOG00000007325 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055030891 UniProtKB/Swiss-Prot
  ENSRNOG00060013905 UniProtKB/Swiss-Prot
  ENSRNOG00065017368 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009724.8 UniProtKB/TrEMBL
  ENSRNOT00000067420 UniProtKB/TrEMBL
  ENSRNOT00000067420.5 UniProtKB/Swiss-Prot
  ENSRNOT00000099397.1 UniProtKB/TrEMBL
  ENSRNOT00000102592.1 UniProtKB/TrEMBL
  ENSRNOT00000119039.1 UniProtKB/TrEMBL
  ENSRNOT00055053897 UniProtKB/Swiss-Prot
  ENSRNOT00060023950 UniProtKB/Swiss-Prot
  ENSRNOT00065029117 UniProtKB/Swiss-Prot
Gene3D-CATH 6.10.250.1720 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cysteine proteinases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C19_UCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:315639 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 315639 ENTREZGENE
PANTHER UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 28 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam UCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Usp28 PhenoGen
PROSITE USP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007325 RatGTEx
  ENSRNOG00055030891 RatGTEx
  ENSRNOG00060013905 RatGTEx
  ENSRNOG00065017368 RatGTEx
Superfamily-SCOP SSF46934 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UI12 ENTREZGENE, UniProtKB/TrEMBL
  A0A140TAA0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZWX4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A8Q3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AFT3 ENTREZGENE, UniProtKB/TrEMBL
  D2Y8W6 ENTREZGENE
  D3ZJ96 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary D2Y8W6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Usp28  ubiquitin specific peptidase 28  Usp28_predicted  ubiquitin specific protease 28 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Usp28_predicted  ubiquitin specific protease 28 (predicted)      Symbol and Name status set to approved 70820 APPROVED