Otub1 (OTU deubiquitinase, ubiquitin aldehyde binding 1) - Rat Genome Database

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Gene: Otub1 (OTU deubiquitinase, ubiquitin aldehyde binding 1) Rattus norvegicus
Analyze
Symbol: Otub1
Name: OTU deubiquitinase, ubiquitin aldehyde binding 1
RGD ID: 1311329
Description: Predicted to enable several functions, including ubiquitin protein ligase binding activity; ubiquitin-like protein peptidase activity; and ubiquitin-protein transferase inhibitor activity. Involved in cellular response to interleukin-1. Predicted to be located in cytoplasm and membrane. Orthologous to human OTUB1 (OTU deubiquitinase, ubiquitin aldehyde binding 1); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; INTERACTS WITH 2,4-dinitrotoluene; 4,4'-sulfonyldiphenol; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: deubiquitinating enzyme OTUB1; LOC293705; OTU domain, ubiquitin aldehyde binding 1; OTU domain-containing ubiquitin aldehyde-binding protein 1; otubain-1; ubiquitin thioesterase OTUB1; ubiquitin-specific-processing protease OTUB1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81213,816,400 - 213,824,679 (-)NCBIGRCr8
mRatBN7.21204,387,215 - 204,395,495 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1204,387,215 - 204,395,483 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1212,737,134 - 212,745,426 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01219,832,446 - 219,840,723 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01212,523,497 - 212,531,775 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,451,674 - 222,459,952 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,451,674 - 222,459,952 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01229,442,242 - 229,450,521 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41209,871,581 - 209,879,518 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11210,030,010 - 210,044,513 (-)NCBI
Celera1201,919,929 - 201,928,118 (-)NCBICelera
Cytogenetic Map1q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Otub1RatIgA glomerulonephritis  ISOOTUB1 (Homo sapiens)7175260protein:increased expression:kidneyRGD 
Otub1Ratlupus nephritis  ISOOTUB1 (Homo sapiens)7175260protein:increased expression:kidneyRGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Otub1Ratintellectual disability  ISOOTUB1 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
Otub1Ratleukocyte adhesion deficiency 3  ISOOTUB1 (Homo sapiens)8554872ClinVar Annotator: match by term: Leukocyte adhesion deficiency 3ClinVarPMID:28492532
Otub1Ratmultiple endocrine neoplasia type 1  ISOOTUB1 (Homo sapiens)8554872ClinVar Annotator: match by term: Multiple endocrine neoplasia and type 1ClinVarPMID:17065424 more ...

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Otub1Rat1,2-dimethylhydrazine increases expressionISOOtub1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of OTUB1 mRNACTDPMID:22206623
Otub1Rat17beta-estradiol increases expressionISOOtub1 (Mus musculus)6480464Estradiol results in increased expression of OTUB1 mRNACTDPMID:39298647
Otub1Rat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISOOTUB1 (Homo sapiens)64804642 more ...CTDPMID:31675489
Otub1Rat2,3',4,4',5-Pentachlorobiphenyl increases expressionISOOtub1 (Mus musculus)64804642 more ...CTDPMID:31388691
Otub1Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of OTUB1 mRNACTDPMID:21346803
Otub1Rat2,6-dimethoxyphenol multiple interactionsISOOTUB1 (Homo sapiens)6480464[pyrogallol 1 and 3-dimethyl ether co-treated with Furaldehyde] results in decreased expression of and affects the localization of OTUB1 proteinCTDPMID:38598786
Otub1Rat2-palmitoylglycerol increases expressionISOOTUB1 (Homo sapiens)64804642-palmitoylglycerol results in increased expression of OTUB1 mRNACTDPMID:37199045
Otub1Rat4,4'-sulfonyldiphenol increases expressionISOOtub1 (Mus musculus)6480464bisphenol S results in increased expression of OTUB1 mRNACTDPMID:39298647
Otub1Rat4,4'-sulfonyldiphenol multiple interactionsEXP 6480464[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of OTUB1 mRNACTDPMID:36041667
Otub1Rat4-hydroxynon-2-enal multiple interactionsISOOTUB1 (Homo sapiens)6480464[[BGN mRNA alternative form binds to OTUB1 protein] which binds to and results in decreased ubiquitination of and results in increased stability of SLC7A11 protein] which results in decreased abundance of 4-hydroxy-2-nonenalCTDPMID:35234341
Otub1Ratamitrole decreases expressionEXP 6480464Amitrole results in decreased expression of OTUB1 mRNACTDPMID:38685447
Otub1Ratbenzo[a]pyrene increases mutagenesisISOOTUB1 (Homo sapiens)6480464Benzo(a)pyrene results in increased mutagenesis of OTUB1 geneCTDPMID:25435355
Otub1Ratbenzo[a]pyrene affects methylationISOOTUB1 (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of OTUB1 promoterCTDPMID:27901495
Otub1Ratbeta-lapachone decreases expressionISOOTUB1 (Homo sapiens)6480464beta-lapachone results in decreased expression of OTUB1 mRNACTDPMID:38218311
Otub1Ratbis(2-ethylhexyl) phthalate increases expressionISOOtub1 (Mus musculus)6480464Diethylhexyl Phthalate results in increased expression of OTUB1 mRNACTDPMID:33754040
Otub1Ratbisphenol A increases expressionISOOtub1 (Mus musculus)6480464bisphenol A results in increased expression of OTUB1 mRNACTDPMID:26063408
Otub1Ratbisphenol A increases expressionISOOTUB1 (Homo sapiens)6480464bisphenol A results in increased expression of OTUB1 proteinCTDPMID:37567409
Otub1Ratbisphenol A multiple interactionsEXP 6480464[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of OTUB1 mRNACTDPMID:36041667
Otub1Ratbisphenol A increases expressionEXP 6480464bisphenol A results in increased expression of OTUB1 mRNACTDPMID:25181051
Otub1RatBisphenol A diglycidyl ether affects splicingISOOtub1 (Mus musculus)6480464bisphenol A diglycidyl ether affects the splicing of OTUB1 mRNACTDPMID:36464114

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Biological Process
1 to 18 of 18 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Otub1Ratadaptive immune response involved_inIEAUniProtKB-KW:KW-10641600115GO_REF:0000043UniProtGO_REF:0000043
Otub1Ratcellular response to interleukin-1  IEP 7175260 RGD 
Otub1RatDNA damage response involved_inISSUniProtKB:Q96FW11600115GO_REF:0000024UniProtGO_REF:0000024
Otub1RatDNA damage response involved_inIEAUniProtKB-KW:KW-02271600115GO_REF:0000043UniProtGO_REF:0000043
Otub1RatDNA damage response involved_inIBAPANTHER:PTN008544236 and UniProtKB:Q96FW11600115GO_REF:0000033GO_CentralGO_REF:0000033
Otub1RatDNA damage response involved_inISOOTUB1 (Homo sapiens)1624291 PMID:20725033RGDPMID:20725033
Otub1RatDNA repair involved_inIEAUniProtKB-KW:KW-02341600115GO_REF:0000043UniProtGO_REF:0000043
Otub1Ratimmune system process involved_inIEAUniProtKB-KW:KW-03911600115GO_REF:0000043UniProtGO_REF:0000043
Otub1Ratnegative regulation of double-strand break repair involved_inISSUniProtKB:Q96FW11600115GO_REF:0000024UniProtGO_REF:0000024
Otub1Ratnegative regulation of double-strand break repair involved_inISOOTUB1 (Homo sapiens)1624291 PMID:20725033RGDPMID:20725033
Otub1Ratpositive regulation of TORC1 signaling involved_inISSUniProtKB:Q96FW11600115GO_REF:0000024UniProtGO_REF:0000024
Otub1Ratpositive regulation of TORC1 signaling involved_inISOOTUB1 (Homo sapiens)1624291 PMID:35927303RGDPMID:35927303
Otub1Ratprotein deubiquitination involved_inISOOTUB1 (Homo sapiens)1624291 PMID:35927303RGDPMID:35927303
Otub1Ratprotein deubiquitination involved_inIEAInterPro:IPR0166151600115GO_REF:0000002InterProGO_REF:0000002
Otub1Ratprotein deubiquitination involved_inISSUniProtKB:Q96FW11600115GO_REF:0000024UniProtGO_REF:0000024
Otub1Ratprotein K48-linked deubiquitination involved_inISSUniProtKB:Q96FW11600115GO_REF:0000024UniProtGO_REF:0000024
Otub1Ratprotein K48-linked deubiquitination involved_inISOOTUB1 (Homo sapiens)1624291 PMID:18954305 more ...RGDPMID:18954305 more ...
Otub1Ratproteolysis involved_inIEAUniProtKB-KW:KW-06451600115GO_REF:0000043UniProtGO_REF:0000043
1 to 18 of 18 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Otub1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Otub1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Otub1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043

Molecular Function
1 to 20 of 20 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Otub1Ratcysteine-type deubiquitinase activity enablesISSUniProtKB:Q96FW11600115GO_REF:0000024UniProtGO_REF:0000024
Otub1Ratcysteine-type deubiquitinase activity enablesIEAEC:3.4.19.121600115GO_REF:0000003UniProtGO_REF:0000003
Otub1Ratcysteine-type deubiquitinase activity enablesIBAPANTHER:PTN000309332 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Otub1Ratcysteine-type deubiquitinase activity enablesISOOTUB1 (Homo sapiens)1624291 PMID:18954305 more ...RGDPMID:18954305 more ...
Otub1Ratcysteine-type deubiquitinase activity enablesIEAUniRule:UR0003293261600115GO_REF:0000104UniProtGO_REF:0000104
Otub1Ratcysteine-type peptidase activity enablesIEAUniProtKB-KW:KW-07881600115GO_REF:0000043UniProtGO_REF:0000043
Otub1RatdeNEDDylase activity enablesISSUniProtKB:Q96FW11600115GO_REF:0000024UniProtGO_REF:0000024
Otub1RatdeNEDDylase activity enablesISOOTUB1 (Homo sapiens)1624291 PMID:18954305RGDPMID:18954305
Otub1Rathydrolase activity enablesIEAInterPro:IPR0166151600115GO_REF:0000002InterProGO_REF:0000002
Otub1Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Otub1Ratpeptidase activity enablesIEAUniProtKB-KW:KW-06451600115GO_REF:0000043UniProtGO_REF:0000043
Otub1Ratprotein binding enablesISOOTUB1 (Homo sapiens) and UniProtKB:Q96FW1-11624291UniProtKB:P61088 and PMID:22367539RGDPMID:22367539
Otub1Ratprotein binding enablesISOOTUB1 (Homo sapiens)1624291UniProtKB:G5E9A7 more ...RGDPMID:16364312 more ...
Otub1Ratubiquitin binding enablesISSUniProtKB:Q96FW11600115GO_REF:0000024UniProtGO_REF:0000024
Otub1Ratubiquitin binding enablesIBAPANTHER:PTN000309332 and UniProtKB:Q96FW11600115GO_REF:0000033GO_CentralGO_REF:0000033
Otub1Ratubiquitin binding enablesIEAUniRule:UR0003293261600115GO_REF:0000104UniProtGO_REF:0000104
Otub1Ratubiquitin binding enablesISOOTUB1 (Homo sapiens)1624291 PMID:19211026RGDPMID:19211026
Otub1Ratubiquitin protein ligase binding enablesISOOTUB1 (Homo sapiens)1624291UniProtKB:P61088 and PMID:20725033RGDPMID:20725033
Otub1Ratubiquitin-protein transferase inhibitor activity enablesISSUniProtKB:Q96FW11600115GO_REF:0000024UniProtGO_REF:0000024
Otub1Ratubiquitin-protein transferase inhibitor activity enablesISOOTUB1 (Homo sapiens)1624291 PMID:35927303RGDPMID:35927303
1 to 20 of 20 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Otub1Ratataxia telangiectasia-mutated (ATM) signaling pathway   ISOOTUB1 (Homo sapiens)8661242 RGD 

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Push back to respond better: regulatory inhibition of the DNA double-strand break response. Panier S and Durocher D, Nat Rev Mol Cell Biol. 2013 Oct;14(10):661-72. doi: 10.1038/nrm3659. Epub 2013 Sep 4.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Comprehensive gene review and curation RGD comprehensive gene curation
5. OTUB1 overexpression in mesangial cells is a novel regulator in the pathogenesis of glomerulonephritis through the decrease of DCN level. Zhang Y, etal., PLoS One. 2012;7(1):e29654. Epub 2012 Jan 18.
PMID:12477932   PMID:18954305   PMID:19056867   PMID:19211026   PMID:20725033   PMID:22871113   PMID:23376485   PMID:23533145   PMID:23827681   PMID:27629786   PMID:29476059  



Otub1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81213,816,400 - 213,824,679 (-)NCBIGRCr8
mRatBN7.21204,387,215 - 204,395,495 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1204,387,215 - 204,395,483 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1212,737,134 - 212,745,426 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01219,832,446 - 219,840,723 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01212,523,497 - 212,531,775 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,451,674 - 222,459,952 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,451,674 - 222,459,952 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01229,442,242 - 229,450,521 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41209,871,581 - 209,879,518 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11210,030,010 - 210,044,513 (-)NCBI
Celera1201,919,929 - 201,928,118 (-)NCBICelera
Cytogenetic Map1q43NCBI
OTUB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381163,986,438 - 63,998,412 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1163,985,853 - 64,001,811 (+)EnsemblGRCh38hg38GRCh38
GRCh371163,753,910 - 63,765,884 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361163,509,901 - 63,522,468 (+)NCBINCBI36Build 36hg18NCBI36
Build 341163,510,460 - 63,522,463NCBI
Celera1161,080,100 - 61,092,667 (+)NCBICelera
Cytogenetic Map11q13.1NCBI
HuRef1160,082,024 - 60,094,513 (+)NCBIHuRef
CHM1_11163,636,649 - 63,649,224 (+)NCBICHM1_1
T2T-CHM13v2.01163,976,132 - 63,988,115 (+)NCBIT2T-CHM13v2.0
Otub1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39197,175,571 - 7,183,649 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl197,175,567 - 7,183,681 (-)EnsemblGRCm39 Ensembl
GRCm38197,198,206 - 7,206,284 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl197,198,202 - 7,206,316 (-)EnsemblGRCm38mm10GRCm38
MGSCv37197,272,696 - 7,280,774 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36197,265,250 - 7,273,328 (-)NCBIMGSCv36mm8
Celera196,975,017 - 6,983,084 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map195.27NCBI
Otub1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542221,047,184 - 21,055,616 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542221,047,184 - 21,055,596 (-)NCBIChiLan1.0ChiLan1.0
OTUB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2965,212,054 - 65,225,024 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11166,257,229 - 66,270,198 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01159,342,820 - 59,355,386 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11162,690,542 - 62,702,739 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1162,690,542 - 62,706,542 (+)Ensemblpanpan1.1panPan2
OTUB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1340,225,531 - 40,226,507 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl340,225,474 - 40,226,612 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1853,034,387 - 53,041,481 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1851,640,620 - 51,647,898 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01854,078,482 - 54,086,513 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1854,078,490 - 54,086,562 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11853,181,634 - 53,188,897 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01852,757,302 - 52,764,567 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01853,541,625 - 53,548,912 (-)NCBIUU_Cfam_GSD_1.0
Otub1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049478,712,639 - 8,721,576 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365995,153,993 - 5,173,046 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365995,154,988 - 5,163,919 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OTUB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl28,087,829 - 8,095,609 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.128,088,528 - 8,095,555 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.227,205,414 - 7,212,452 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OTUB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1110,247,260 - 10,271,026 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038107,583,188 - 107,596,053 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Otub1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476722,278,572 - 22,289,640 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476722,278,572 - 22,289,576 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Otub1
31 total Variants

Predicted Target Of
Summary Value
Count of predictions:154
Count of miRNA genes:113
Interacting mature miRNAs:133
Transcripts:ENSRNOT00000028752
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 84 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat

1 to 10 of 84 rows
RH132561  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21204,387,415 - 204,387,608 (+)MAPPERmRatBN7.2
Rnor_6.01222,451,875 - 222,452,067NCBIRnor6.0
Rnor_5.01229,442,443 - 229,442,635UniSTSRnor5.0
RGSC_v3.41209,871,782 - 209,871,974UniSTSRGSC3.4
Celera1201,920,130 - 201,920,322UniSTS
RH 3.4 Map11521.1UniSTS
Cytogenetic Map1q43UniSTS
RH142168  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21204,388,079 - 204,388,415 (+)MAPPERmRatBN7.2
mRatBN7.2714,196,502 - 14,196,708 (+)MAPPERmRatBN7.2
Rnor_6.0718,280,689 - 18,280,894NCBIRnor6.0
Rnor_6.01222,452,539 - 222,452,874NCBIRnor6.0
Rnor_5.0718,453,070 - 18,453,275UniSTSRnor5.0
Rnor_5.01229,443,107 - 229,443,442UniSTSRnor5.0
RGSC_v3.41209,872,446 - 209,872,781UniSTSRGSC3.4
RGSC_v3.4715,904,746 - 15,904,951UniSTSRGSC3.4
Celera713,102,078 - 13,102,283UniSTS
Celera1201,920,794 - 201,921,129UniSTS
RH 3.4 Map768.0UniSTS
Cytogenetic Map1q43UniSTS
Cytogenetic Map7q12UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000028752   ⟹   ENSRNOP00000028752
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1204,387,215 - 204,395,478 (-)Ensembl
Rnor_6.0 Ensembl1222,451,674 - 222,459,952 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095568   ⟹   ENSRNOP00000090096
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1204,388,032 - 204,395,477 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101186   ⟹   ENSRNOP00000088887
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1204,387,232 - 204,395,483 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114563   ⟹   ENSRNOP00000077159
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1204,387,880 - 204,395,481 (-)Ensembl
RefSeq Acc Id: NM_001106332   ⟹   NP_001099802
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81213,816,400 - 213,824,679 (-)NCBI
mRatBN7.21204,387,215 - 204,395,495 (-)NCBI
Rnor_6.01222,451,674 - 222,459,952 (-)NCBI
Rnor_5.01229,442,242 - 229,450,521 (-)NCBI
RGSC_v3.41209,871,581 - 209,879,518 (-)RGD
Celera1201,919,929 - 201,928,118 (-)RGD
Sequence:
Protein RefSeqs NP_001099802 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66771 (Get FASTA)   NCBI Sequence Viewer  
  B2RYG6 (Get FASTA)   NCBI Sequence Viewer  
  EDM12666 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000028752
  ENSRNOP00000088887.1
RefSeq Acc Id: NP_001099802   ⟸   NM_001106332
- UniProtKB: B2RYG6 (UniProtKB/Swiss-Prot),   A0A8L2QFR7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028752   ⟸   ENSRNOT00000028752
Ensembl Acc Id: ENSRNOP00000077159   ⟸   ENSRNOT00000114563
Ensembl Acc Id: ENSRNOP00000088887   ⟸   ENSRNOT00000101186
Ensembl Acc Id: ENSRNOP00000090096   ⟸   ENSRNOT00000095568
OTU

Name Modeler Protein Id AA Range Protein Structure
AF-B2RYG6-F1-model_v2 AlphaFold B2RYG6 1-271 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690718
Promoter ID:EPDNEW_R1243
Type:multiple initiation site
Name:Otub1_1
Description:OTU deubiquitinase, ubiquitin aldehyde binding 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01222,459,946 - 222,460,006EPDNEW


1 to 28 of 28 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-56560 BioCyc
Ensembl Genes ENSRNOG00000021175 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028752 ENTREZGENE
  ENSRNOT00000101186.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1300.20 UniProtKB/Swiss-Prot
  3.30.200.60 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7934088 IMAGE-MGC_LOAD
InterPro OTU_dom UniProtKB/Swiss-Prot
  Otubain UniProtKB/Swiss-Prot
  Papain-like_cys_pep_sf UniProtKB/Swiss-Prot
  Peptidase_C65_otubain UniProtKB/Swiss-Prot
  Peptidase_C65_otubain_sub1 UniProtKB/Swiss-Prot
  Peptidase_C65_otubain_sub2 UniProtKB/Swiss-Prot
KEGG Report rno:293705 UniProtKB/Swiss-Prot
MGC_CLONE MGC:188546 IMAGE-MGC_LOAD
NCBI Gene 293705 ENTREZGENE
PANTHER PTHR12931 UniProtKB/Swiss-Prot
  PTHR12931:SF19 UniProtKB/Swiss-Prot
Pfam Peptidase_C65 UniProtKB/Swiss-Prot
PhenoGen Otub1 PhenoGen
PIRSF Ubiquitin_thioesterase_Otubain UniProtKB/Swiss-Prot
PROSITE OTU UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000021175 RatGTEx
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot
UniProt A0A8I5XVU7_RAT UniProtKB/TrEMBL
  A0A8I6ABS1_RAT UniProtKB/TrEMBL
  A0A8L2QFR7 ENTREZGENE, UniProtKB/TrEMBL
  B2RYG6 ENTREZGENE, UniProtKB/Swiss-Prot
1 to 28 of 28 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-13 Otub1  OTU deubiquitinase, ubiquitin aldehyde binding 1  Otub1  OTU domain, ubiquitin aldehyde binding 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Otub1  OTU domain, ubiquitin aldehyde binding 1   Otub1_predicted  OTU domain, ubiquitin aldehyde binding 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Otub1_predicted  OTU domain, ubiquitin aldehyde binding 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED