Mgst2 (microsomal glutathione S-transferase 2) - Rat Genome Database

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Gene: Mgst2 (microsomal glutathione S-transferase 2) Rattus norvegicus
Analyze
Symbol: Mgst2
Name: microsomal glutathione S-transferase 2
RGD ID: 1311218
Description: Enables glutathione peroxidase activity; glutathione transferase activity; and leukotriene-C4 synthase activity. Involved in response to lipopolysaccharide. Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Predicted to be active in endoplasmic reticulum and nuclear envelope. Orthologous to human MGST2 (microsomal glutathione S-transferase 2); PARTICIPATES IN glutathione metabolic pathway; phase I biotransformation pathway via cytochrome P450; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC295037
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82137,821,787 - 137,866,664 (+)NCBIGRCr8
mRatBN7.22135,679,524 - 135,715,828 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2135,693,557 - 135,715,828 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2142,269,446 - 142,291,715 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02140,381,704 - 140,403,975 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02135,013,740 - 135,035,919 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02140,708,396 - 140,727,381 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2140,708,397 - 140,727,281 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02160,180,714 - 160,202,851 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42140,546,939 - 140,568,616 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12140,497,066 - 140,518,579 (+)NCBI
Celera2130,188,760 - 130,210,429 (+)NCBICelera
Cytogenetic Map2q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 160 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mgst2Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of MGST2 mRNA]CTDPMID:31150632
Mgst2Rat1,1-dichloroethene increases expressionISOMgst2 (Mus musculus)6480464vinylidene chloride results in increased expression of MGST2 mRNACTDPMID:26682919
Mgst2Rat1,2-dimethylhydrazine multiple interactionsISOMgst2 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of MGST2 mRNACTDPMID:22206623
Mgst2Rat1,2-dimethylhydrazine decreases expressionISOMgst2 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of MGST2 mRNACTDPMID:22206623
Mgst2Rat1-naphthyl isothiocyanate multiple interactionsISOMGST2 (Homo sapiens)6480464[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of MGST2 mRNACTDPMID:27344345
Mgst2Rat17beta-estradiol increases expressionISOMGST2 (Homo sapiens)6480464Estradiol results in increased expression of MGST2 mRNACTDPMID:19167446
Mgst2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOMGST2 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in decreased expression of MGST2 mRNACTDPMID:15056799 more ...
Mgst2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of MGST2 mRNACTDPMID:34747641
Mgst2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOMgst2 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of MGST2 mRNACTDPMID:21570461
Mgst2Rat2,4,6-trinitrotoluene affects expressionEXP 6480464Trinitrotoluene affects the expression of MGST2 mRNACTDPMID:21346803
Mgst2Rat2-acetamidofluorene multiple interactionsEXP 6480464[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of MGST2 mRNA and [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MGST2 mRNACTDPMID:14656948 and PMID:16158176
Mgst2Rat2-methylcholine affects expressionISOMGST2 (Homo sapiens)6480464beta-methylcholine affects the expression of MGST2 mRNACTDPMID:21179406
Mgst2Rat3,3',4,4',5-pentachlorobiphenyl decreases expressionISOMGST2 (Homo sapiens)64804643 more ...CTDPMID:23146750
Mgst2Rat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOMGST2 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of MGST2 mRNACTDPMID:28628672
Mgst2Rat3-methylcholanthrene multiple interactionsISOMGST2 (Homo sapiens)6480464Methylcholanthrene promotes the reaction [AHR protein binds to MGST2 promoter]CTDPMID:20348232
Mgst2Rat3H-1,2-dithiole-3-thione increases expressionEXP 64804641 and 2-dithiol-3-thione results in increased expression of MGST2 mRNACTDPMID:19162173
Mgst2Rat4,4'-sulfonyldiphenol multiple interactionsISOMGST2 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of MGST2 mRNACTDPMID:28628672
Mgst2Rat4-(ethoxymethylene)-2-phenyloxazol-5-one decreases expressionISOMgst2 (Mus musculus)6480464Oxazolone results in decreased expression of MGST2 mRNACTDPMID:21404309
Mgst2Rat4-amino-2,6-dinitrotoluene affects expressionEXP 64804644-amino-2 and 6-dinitrotoluene affects the expression of MGST2 mRNACTDPMID:21346803
Mgst2Rat4-hydroxyphenyl retinamide increases expressionISOMgst2 (Mus musculus)6480464Fenretinide results in increased expression of MGST2 mRNACTDPMID:28973697

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Biological Process
1 to 17 of 17 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mgst2Ratcellular oxidant detoxification involved_inIEAGO:00046021600115GO_REF:0000108GOCGO_REF:0000108
Mgst2Ratglutathione biosynthetic process involved_inISOMGST2 (Homo sapiens)1624291 PMID:8703034RGDPMID:8703034
Mgst2Ratglutathione biosynthetic process involved_inIEAUniProtKB:Q99735 and ensembl:ENSP000002654981600115GO_REF:0000107EnsemblGO_REF:0000107
Mgst2Ratleukotriene biosynthetic process involved_inISOMGST2 (Homo sapiens)1624291 PMID:23409838 more ...RGDPMID:23409838 more ...
Mgst2Ratleukotriene biosynthetic process involved_inIEAUniRule:UR0019337821600115GO_REF:0000104UniProtGO_REF:0000104
Mgst2Ratleukotriene biosynthetic process involved_inIBAMGI:107505 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Mgst2Ratleukotriene biosynthetic process involved_inIEAUniProtKB:Q99735 and ensembl:ENSP000002654981600115GO_REF:0000107EnsemblGO_REF:0000107
Mgst2Ratleukotriene biosynthetic process involved_inIEAUniProtKB-KW:KW-04341600115GO_REF:0000043UniProtGO_REF:0000043
Mgst2Ratleukotriene metabolic process involved_inIEAARBA:ARBA000287311600115GO_REF:0000117UniProtGO_REF:0000117
Mgst2Ratleukotriene metabolic process involved_inIEAInterPro:IPR0014461600115GO_REF:0000002InterProGO_REF:0000002
Mgst2Ratlipid metabolic process involved_inISOMGST2 (Homo sapiens)1624291 PMID:9278457RGDPMID:9278457
Mgst2Ratlipid metabolic process involved_inIEAUniProtKB-KW:KW-04431600115GO_REF:0000043UniProtGO_REF:0000043
Mgst2Ratlipid metabolic process involved_inIEAUniRule:UR0019337821600115GO_REF:0000104UniProtGO_REF:0000104
Mgst2Ratlipid metabolic process involved_inIEAUniProtKB:Q99735 and ensembl:ENSP000002654981600115GO_REF:0000107EnsemblGO_REF:0000107
Mgst2Ratmembrane lipid catabolic process involved_inISOMGST2 (Homo sapiens)1624291 PMID:23409838RGDPMID:23409838
Mgst2Ratmembrane lipid catabolic process involved_inIEAUniProtKB:Q99735 and ensembl:ENSP000002654981600115GO_REF:0000107EnsemblGO_REF:0000107
Mgst2Ratresponse to lipopolysaccharide  IEP 2302283 RGD 
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Cellular Component
1 to 14 of 14 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mgst2Ratendoplasmic reticulum is_active_inIBAPANTHER:PTN000741656 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Mgst2Ratendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
Mgst2Ratendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-00971600115GO_REF:0000044UniProtGO_REF:0000044
Mgst2Ratendoplasmic reticulum membrane located_inIEAUniRule:UR0019337821600115GO_REF:0000104UniProtGO_REF:0000104
Mgst2Ratintracellular membrane-bounded organelle located_inIEAUniProtKB-KW:KW-04921600115GO_REF:0000043UniProtGO_REF:0000043
Mgst2Ratintracellular membrane-bounded organelle located_inIEAUniProtKB:Q99735 and ensembl:ENSP000002654981600115GO_REF:0000107EnsemblGO_REF:0000107
Mgst2Ratintracellular membrane-bounded organelle located_inISOMGST2 (Homo sapiens)1624291 PMID:8703034 and PMID:9278457RGDPMID:8703034 and PMID:9278457
Mgst2Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Mgst2Ratmembrane located_inIEAUniProtKB:Q99735 and ensembl:ENSP000002654981600115GO_REF:0000107EnsemblGO_REF:0000107
Mgst2Ratmembrane located_inIEAInterPro:IPR001129 and InterPro:IPR0014461600115GO_REF:0000002InterProGO_REF:0000002
Mgst2Ratmembrane located_inISOMGST2 (Homo sapiens)1624291 PMID:9278457RGDPMID:9278457
Mgst2Ratnuclear envelope is_active_inIBAPANTHER:PTN000741656 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Mgst2Ratplasma membrane located_inISOMGST2 (Homo sapiens)1624291 PMID:9092565RGDPMID:9092565
Mgst2Ratplasma membrane located_inIEAUniProtKB:Q99735 and ensembl:ENSP000002654981600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function
1 to 20 of 25 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mgst2Ratenzyme activator activity enablesIEAUniRule:UR0019337821600115GO_REF:0000104UniProtGO_REF:0000104
Mgst2Ratenzyme activator activity enablesIEAInterPro:IPR0014461600115GO_REF:0000002InterProGO_REF:0000002
Mgst2Ratglutathione binding enablesISOMGST2 (Homo sapiens)1624291 PMID:26066610RGDPMID:26066610
Mgst2Ratglutathione binding enablesIEAUniProtKB:Q99735 and ensembl:ENSP000002654981600115GO_REF:0000107EnsemblGO_REF:0000107
Mgst2Ratglutathione binding enablesIEAUniRule:UR0019337821600115GO_REF:0000104UniProtGO_REF:0000104
Mgst2Ratglutathione peroxidase activity enablesISOMGST2 (Homo sapiens)1624291 PMID:23409838 and PMID:9278457RGDPMID:23409838 and PMID:9278457
Mgst2Ratglutathione peroxidase activity  IDA 2302289 RGD 
Mgst2Ratglutathione peroxidase activity enablesIEAUniProtKB:Q99735 and ensembl:ENSP000002654981600115GO_REF:0000107EnsemblGO_REF:0000107
Mgst2Ratglutathione peroxidase activity enablesIBAPANTHER:PTN000028575 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Mgst2Ratglutathione peroxidase activity enablesIEAUniRule:UR0019337821600115GO_REF:0000104UniProtGO_REF:0000104
Mgst2Ratglutathione transferase activity enablesISOMGST2 (Homo sapiens)1624291 PMID:23409838 and PMID:8703034RGDPMID:23409838 and PMID:8703034
Mgst2Ratglutathione transferase activity  IDA 2302289 RGD 
Mgst2Ratglutathione transferase activity enablesIEAUniRule:UR0019337821600115GO_REF:0000104UniProtGO_REF:0000104
Mgst2Ratglutathione transferase activity enablesIBAPANTHER:PTN000028575 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Mgst2Ratglutathione transferase activity enablesIEAUniProtKB:Q99735 and ensembl:ENSP000002654981600115GO_REF:0000107EnsemblGO_REF:0000107
Mgst2Ratidentical protein binding enablesISOMGST2 (Homo sapiens)1624291UniProtKB:Q99735 more ...RGDPMID:26066610 and PMID:32296183
Mgst2Ratidentical protein binding enablesIEAUniProtKB:Q99735 and ensembl:ENSP000002654981600115GO_REF:0000107EnsemblGO_REF:0000107
Mgst2Ratleukotriene-C4 synthase activity enablesISOMGST2 (Homo sapiens)1624291 PMID:23409838 more ...RGDPMID:23409838 more ...
Mgst2Ratleukotriene-C4 synthase activity  IDA 2302289 RGD 
Mgst2Ratleukotriene-C4 synthase activity enablesIEAUniProtKB:Q99735 and ensembl:ENSP000002654981600115GO_REF:0000107EnsemblGO_REF:0000107
1 to 20 of 25 rows

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mgst2Ratglutathione metabolic pathway  IEA 6907045 KEGGrno:00480
Mgst2Ratphase I biotransformation pathway via cytochrome P450  IEA 6907045 KEGGrno:00980
Mgst2Ratphase I biotransformation pathway via cytochrome P450  IEA 6907045 KEGGrno:00982

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#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Enhanced expressions and activations of leukotriene C4 synthesis enzymes in D-galactosamine/lipopolysaccharide-induced rat fulminant hepatic failure model. Ma KF, etal., World J Gastroenterol. 2008 May 7;14(17):2748-56.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. Molecular and catalytic properties of three rat leukotriene C(4) synthase homologs. Schroder O, etal., Biochem Biophys Res Commun. 2003 Dec 12;312(2):271-6.
9. The role of glutathione-S-transferase in anti-cancer drug resistance. Townsend DM and Tew KD, Oncogene 2003 Oct 20;22(47):7369-75.
10. Sodium nitroprusside regulates mRNA expressions of LTC4 synthesis enzymes in hepatic ischemia/reperfusion injury rats via NF-kappaB signaling pathway. Yang SL, etal., Pharmacology. 2007;80(1):11-20. Epub 2007 May 10.
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PMID:8703034   PMID:9092565   PMID:9278457   PMID:23409838   PMID:26066610  



Mgst2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82137,821,787 - 137,866,664 (+)NCBIGRCr8
mRatBN7.22135,679,524 - 135,715,828 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2135,693,557 - 135,715,828 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2142,269,446 - 142,291,715 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02140,381,704 - 140,403,975 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02135,013,740 - 135,035,919 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02140,708,396 - 140,727,381 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2140,708,397 - 140,727,281 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02160,180,714 - 160,202,851 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42140,546,939 - 140,568,616 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12140,497,066 - 140,518,579 (+)NCBI
Celera2130,188,760 - 130,210,429 (+)NCBICelera
Cytogenetic Map2q26NCBI
MGST2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384139,665,819 - 139,754,618 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4139,665,768 - 139,740,745 (+)EnsemblGRCh38hg38GRCh38
GRCh374140,586,973 - 140,661,899 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364140,806,372 - 140,844,857 (+)NCBINCBI36Build 36hg18NCBI36
Build 344140,944,526 - 140,983,009NCBI
Celera4137,919,740 - 137,958,224 (+)NCBICelera
Cytogenetic Map4q31.1NCBI
HuRef4136,315,768 - 136,391,008 (+)NCBIHuRef
CHM1_14140,564,114 - 140,639,227 (+)NCBICHM1_1
T2T-CHM13v2.04142,985,421 - 143,074,258 (+)NCBIT2T-CHM13v2.0
Mgst2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39351,544,179 - 51,590,096 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl351,567,781 - 51,590,098 (+)EnsemblGRCm39 Ensembl
GRCm38351,636,912 - 51,682,675 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl351,660,360 - 51,682,677 (+)EnsemblGRCm38mm10GRCm38
MGSCv37351,465,115 - 51,486,597 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36351,749,166 - 51,770,603 (+)NCBIMGSCv36mm8
Celera351,392,546 - 51,414,043 (+)NCBICelera
Cytogenetic Map3CNCBI
cM Map322.52NCBI
Mgst2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554284,014,810 - 4,037,901 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554284,006,054 - 4,049,497 (-)NCBIChiLan1.0ChiLan1.0
MGST2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23137,540,753 - 137,605,499 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14137,933,175 - 137,997,878 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04132,031,087 - 132,106,864 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14143,338,016 - 143,412,966 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4143,338,016 - 143,412,966 (+)Ensemblpanpan1.1panPan2
MGST2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1193,067,062 - 3,070,579 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha193,314,243 - 3,335,238 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0193,136,172 - 3,157,176 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl193,122,591 - 3,157,324 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1193,069,101 - 3,090,099 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0193,429,861 - 3,450,892 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0193,793,259 - 3,814,268 (-)NCBIUU_Cfam_GSD_1.0
Mgst2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530150,548,928 - 50,578,317 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365357,995,248 - 8,015,463 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365357,995,185 - 8,015,463 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MGST2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl887,327,425 - 87,390,520 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1887,318,180 - 87,394,563 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MGST2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1786,629,691 - 86,666,912 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl786,629,642 - 86,666,857 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603766,152,315 - 66,189,340 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mgst2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477719,901,862 - 19,927,011 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477719,902,013 - 19,924,272 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Mgst2
195 total Variants

Predicted Target Of
Summary Value
Count of predictions:103
Count of miRNA genes:92
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000017785
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2129164097152195315Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2122609194206936711Rat

1 to 10 of 58 rows
RH142268  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82137,865,782 - 137,866,538 (+)Marker Load Pipeline
mRatBN7.22135,714,946 - 135,715,702 (+)MAPPERmRatBN7.2
Rnor_6.02140,726,500 - 140,727,255NCBIRnor6.0
Rnor_5.02160,201,970 - 160,202,725UniSTSRnor5.0
RGSC_v3.42140,567,735 - 140,568,490UniSTSRGSC3.4
Celera2130,209,548 - 130,210,303UniSTS
RH 3.4 Map2848.3UniSTS
Cytogenetic Map2q26UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000088846   ⟹   ENSRNOP00000068920
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2135,693,695 - 135,715,807 (+)Ensembl
Rnor_6.0 Ensembl2140,708,397 - 140,727,281 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100251   ⟹   ENSRNOP00000078333
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2135,693,557 - 135,715,828 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101526   ⟹   ENSRNOP00000081569
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2135,693,557 - 135,715,618 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118372   ⟹   ENSRNOP00000090331
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2135,693,557 - 135,714,999 (+)Ensembl
RefSeq Acc Id: NM_001106430   ⟹   NP_001099900
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82137,844,393 - 137,866,664 (+)NCBI
mRatBN7.22135,693,556 - 135,715,828 (+)NCBI
Rnor_6.02140,708,396 - 140,727,381 (+)NCBI
Rnor_5.02160,180,714 - 160,202,851 (+)NCBI
RGSC_v3.42140,546,939 - 140,568,616 (+)RGD
Celera2130,188,760 - 130,210,429 (+)RGD
Sequence:
RefSeq Acc Id: XM_039102008   ⟹   XP_038957936
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82137,844,452 - 137,865,823 (+)NCBI
mRatBN7.22135,693,616 - 135,712,391 (+)NCBI
RefSeq Acc Id: XM_063281573   ⟹   XP_063137643
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82137,844,159 - 137,866,660 (+)NCBI
RefSeq Acc Id: XM_063281574   ⟹   XP_063137644
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82137,844,345 - 137,866,660 (+)NCBI
RefSeq Acc Id: XM_063281575   ⟹   XP_063137645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82137,836,108 - 137,866,660 (+)NCBI
RefSeq Acc Id: XM_063281576   ⟹   XP_063137646
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82137,843,930 - 137,866,660 (+)NCBI
RefSeq Acc Id: XM_063281577   ⟹   XP_063137647
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82137,835,516 - 137,866,660 (+)NCBI
RefSeq Acc Id: XM_063281578   ⟹   XP_063137648
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82137,821,787 - 137,866,660 (+)NCBI
1 to 5 of 12 rows
1 to 5 of 12 rows
RefSeq Acc Id: NP_001099900   ⟸   NM_001106430
- UniProtKB: A0A8I5ZLK2 (UniProtKB/TrEMBL),   A6JV75 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068920   ⟸   ENSRNOT00000088846
RefSeq Acc Id: XP_038957936   ⟸   XM_039102008
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZSH5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000078333   ⟸   ENSRNOT00000100251
Ensembl Acc Id: ENSRNOP00000081569   ⟸   ENSRNOT00000101526

Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JU12-F1-model_v2 AlphaFold A0A0G2JU12 1-128 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 31 of 31 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-53123 BioCyc
BioCyc Pathway PWY-4061 [glutathione-mediated detoxification I] BioCyc
  PWY-7112 [4-hydroxy-2-nonenal detoxification] BioCyc
BioCyc Pathway Image PWY-4061 BioCyc
  PWY-7112 BioCyc
Ensembl Genes ENSRNOG00000061857 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000088846.2 UniProtKB/TrEMBL
  ENSRNOT00000100251 ENTREZGENE
  ENSRNOT00000100251.1 UniProtKB/TrEMBL
  ENSRNOT00000101526.1 UniProtKB/TrEMBL
  ENSRNOT00000118372.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.550 UniProtKB/TrEMBL
InterPro 5_LipOase_AP UniProtKB/TrEMBL
  MAPEG UniProtKB/TrEMBL
  MAPEG-like_dom UniProtKB/TrEMBL
  Membr-assoc_MAPEG UniProtKB/TrEMBL
KEGG Report rno:295037 UniProtKB/TrEMBL
NCBI Gene 295037 ENTREZGENE
PANTHER MICROSOMAL GLUTATHIONE S-TRANSFERASE UniProtKB/TrEMBL
  MICROSOMAL GLUTATHIONE S-TRANSFERASE 2 UniProtKB/TrEMBL
Pfam MAPEG UniProtKB/TrEMBL
PharmGKB MGST2 RGD
PhenoGen Mgst2 PhenoGen
PRINTS 5LPOXGNASEAP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000061857 RatGTEx
Superfamily-SCOP SSF161084 UniProtKB/TrEMBL
UniProt A0A0G2JU12_RAT UniProtKB/TrEMBL
  A0A8I5ZLK2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZSH5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ADF7_RAT UniProtKB/TrEMBL
  A6JV75 ENTREZGENE, UniProtKB/TrEMBL
1 to 31 of 31 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Mgst2  microsomal glutathione S-transferase 2   Mgst2_predicted  microsomal glutathione S-transferase 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Mgst2_predicted  microsomal glutathione S-transferase 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED