Usp45 (ubiquitin specific peptidase 45) - Rat Genome Database

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Gene: Usp45 (ubiquitin specific peptidase 45) Rattus norvegicus
Analyze
Symbol: Usp45
Name: ubiquitin specific peptidase 45
RGD ID: 1310976
Description: Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in cell migration and photoreceptor cell maintenance. Predicted to act upstream of or within DNA repair and protein deubiquitination. Predicted to be located in cytosol; nucleoplasm; and photoreceptor inner segment. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 19. Orthologous to human USP45 (ubiquitin specific peptidase 45); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC313098; ubiquitin carboxyl-terminal hydrolase 45; ubiquitin specific petidase 45; ubiquitin specific protease 45
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8540,115,394 - 40,188,861 (+)NCBIGRCr8
mRatBN7.2535,318,621 - 35,392,090 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl535,318,635 - 35,389,420 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx537,442,950 - 37,516,428 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0539,035,678 - 39,109,156 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0538,975,187 - 39,048,666 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0535,916,763 - 35,984,525 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl535,916,804 - 35,984,524 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0540,573,111 - 40,639,487 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4536,517,213 - 36,590,986 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1536,502,821 - 36,587,983 (+)NCBI
Celera534,335,326 - 34,403,408 (+)NCBICelera
Cytogenetic Map5q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp45RatDwarfism  ISOUSP45 (Homo sapiens)8554872ClinVar Annotator: match by term: Short statureClinVar 
Usp45Ratfundus dystrophy  ISOUSP45 (Homo sapiens)8554872ClinVar Annotator: match by term: Retinal dystrophyClinVarPMID:25741868 and PMID:31345219
Usp45RatLaterality Defects, Autosomal Dominant  ISOUSP45 (Homo sapiens)8554872ClinVar Annotator: match by term: Laterality defects and autosomal dominantClinVar 
Usp45RatLeber congenital amaurosis 19  ISOUSP45 (Homo sapiens)8554872ClinVar Annotator: match by term: Leber congenital amaurosis 19ClinVarPMID:25741868 and PMID:30573563
Usp45Ratoptic atrophy  ISOUSP45 (Homo sapiens)8554872ClinVar Annotator: match by term: Optic atrophyClinVarPMID:25741868
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp45RatLeber congenital amaurosis 19  ISSUsp45 (Mus musculus)13592920 MouseDO 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp45RatLeber congenital amaurosis 19  ISOUSP45 (Homo sapiens)7240710 OMIM 

1 to 20 of 64 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp45Rat(1->4)-beta-D-glucan multiple interactionsISOUsp45 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of USP45 mRNACTDPMID:36331819
Usp45Rat1,2-dimethylhydrazine multiple interactionsISOUsp45 (Mus musculus)6480464Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of USP45 mRNA]CTDPMID:22206623
Usp45Rat1,2-dimethylhydrazine decreases expressionISOUsp45 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of USP45 mRNACTDPMID:22206623
Usp45Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of USP45 mRNACTDPMID:29097150
Usp45Rat17beta-estradiol increases expressionISOUSP45 (Homo sapiens)6480464Estradiol results in increased expression of USP45 mRNACTDPMID:31614463
Usp45Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOUsp45 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of USP45 mRNACTDPMID:21570461
Usp45Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of USP45 mRNACTDPMID:33387578
Usp45Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of USP45 mRNACTDPMID:32109520
Usp45Rat3,4-methylenedioxymethamphetamine decreases expressionEXP 6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of USP45 mRNACTDPMID:30071829
Usp45Ratacrolein multiple interactionsISOUSP45 (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of USP45 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of USP45 mRNACTDPMID:32699268
Usp45Rataflatoxin B1 increases expressionISOUsp45 (Mus musculus)6480464Aflatoxin B1 results in increased expression of USP45 mRNACTDPMID:19770486
Usp45Rataflatoxin B1 increases methylationISOUSP45 (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of USP45 intronCTDPMID:30157460
Usp45RatAflatoxin B2 alpha increases methylationISOUSP45 (Homo sapiens)6480464aflatoxin B2 results in increased methylation of USP45 intronCTDPMID:30157460
Usp45Ratall-trans-retinoic acid decreases expressionISOUSP45 (Homo sapiens)6480464Tretinoin results in decreased expression of USP45 mRNACTDPMID:33167477
Usp45Ratalpha-pinene multiple interactionsISOUSP45 (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of USP45 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of USP45 mRNACTDPMID:32699268
Usp45Ratarsane affects methylationISOUSP45 (Homo sapiens)6480464Arsenic affects the methylation of USP45 geneCTDPMID:25304211
Usp45Ratarsenic atom affects methylationISOUSP45 (Homo sapiens)6480464Arsenic affects the methylation of USP45 geneCTDPMID:25304211
Usp45Ratbenzo[e]pyrene increases methylationISOUSP45 (Homo sapiens)6480464benzo(e)pyrene results in increased methylation of USP45 intronCTDPMID:30157460
Usp45Ratbeta-lapachone increases expressionISOUSP45 (Homo sapiens)6480464beta-lapachone results in increased expression of USP45 mRNACTDPMID:38218311
Usp45Ratbeta-lapachone decreases expressionISOUSP45 (Homo sapiens)6480464beta-lapachone results in decreased expression of USP45 mRNACTDPMID:38218311

1 to 20 of 64 rows

Biological Process
1 to 10 of 10 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp45Ratcell migration involved_inISOUSP45 (Homo sapiens)1624291 PMID:30258100RGDPMID:30258100
Usp45Ratcell migration involved_inIEAUniProtKB:Q70EL2 and ensembl:ENSP000004243721600115GO_REF:0000107EnsemblGO_REF:0000107
Usp45RatDNA repair acts_upstream_of_or_withinISOUSP45 (Homo sapiens)1624291 PMID:25538220RGDPMID:25538220
Usp45RatDNA repair acts_upstream_of_or_withinIEAUniProtKB:Q70EL2 and ensembl:ENSP000004243721600115GO_REF:0000107EnsemblGO_REF:0000107
Usp45Ratphotoreceptor cell maintenance involved_inISOUsp45 (Mus musculus)1624291 PMID:30573563RGDPMID:30573563
Usp45Ratphotoreceptor cell maintenance involved_inIEAUniProtKB:Q8K387 and ensembl:ENSMUSP000000671091600115GO_REF:0000107EnsemblGO_REF:0000107
Usp45Ratprotein deubiquitination acts_upstream_of_or_withinISOUSP45 (Homo sapiens)1624291 PMID:25538220RGDPMID:25538220
Usp45Ratprotein deubiquitination acts_upstream_of_or_withinIEAUniProtKB:Q70EL2 and ensembl:ENSP000004243721600115GO_REF:0000107EnsemblGO_REF:0000107
Usp45Ratprotein deubiquitination involved_inIEAInterPro:IPR0013941600115GO_REF:0000002InterProGO_REF:0000002
Usp45Ratproteolysis involved_inIEAUniProtKB-KW:KW-06451600115GO_REF:0000043UniProtGO_REF:0000043
1 to 10 of 10 rows

Cellular Component
1 to 10 of 10 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp45Ratcytoplasm located_inISOUSP45 (Homo sapiens)1624291 PMID:25538220RGDPMID:25538220
Usp45Ratcytoplasm located_inIEAUniProtKB:Q70EL2 and ensembl:ENSP000004243721600115GO_REF:0000107EnsemblGO_REF:0000107
Usp45Ratcytosol located_inISOUSP45 (Homo sapiens) and UniProtKB:Q70EL2-11624291 RGDGO_REF:0000052
Usp45Ratcytosol located_inIEAUniProtKB:Q70EL2 and ensembl:ENSP000004243721600115GO_REF:0000107EnsemblGO_REF:0000107
Usp45Ratnucleoplasm located_inIEAUniProtKB:Q70EL2 and ensembl:ENSP000004243721600115GO_REF:0000107EnsemblGO_REF:0000107
Usp45Ratnucleoplasm located_inISOUSP45 (Homo sapiens) and UniProtKB:Q70EL2-11624291 RGDGO_REF:0000052
Usp45Ratnucleus located_inISOUSP45 (Homo sapiens)1624291 PMID:25538220RGDPMID:25538220
Usp45Ratnucleus located_inIEAUniProtKB:Q70EL2 and ensembl:ENSP000004243721600115GO_REF:0000107EnsemblGO_REF:0000107
Usp45Ratphotoreceptor inner segment located_inISOUSP45 (Homo sapiens)1624291 PMID:30573563RGDPMID:30573563
Usp45Ratphotoreceptor inner segment located_inIEAUniProtKB:Q70EL2 and ensembl:ENSP000004243721600115GO_REF:0000107EnsemblGO_REF:0000107
1 to 10 of 10 rows

Molecular Function
1 to 13 of 13 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp45Ratcysteine-type deubiquitinase activity enablesISOUSP45 (Homo sapiens)1624291 PMID:14715245 more ...RGDPMID:14715245 more ...
Usp45Ratcysteine-type deubiquitinase activity enablesIEAEC:3.4.19.121600115GO_REF:0000003UniProtGO_REF:0000003
Usp45Ratcysteine-type deubiquitinase activity enablesIEAUniProtKB:Q70EL2 and ensembl:ENSP000004243721600115GO_REF:0000107EnsemblGO_REF:0000107
Usp45Ratcysteine-type deubiquitinase activity enablesIEAUniRule:UR0008807561600115GO_REF:0000104UniProtGO_REF:0000104
Usp45Ratcysteine-type deubiquitinase activity enablesIEAInterPro:IPR001394 and InterPro:IPR0182001600115GO_REF:0000002InterProGO_REF:0000002
Usp45Ratcysteine-type peptidase activity enablesIEAUniProtKB-KW:KW-07881600115GO_REF:0000043UniProtGO_REF:0000043
Usp45Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Usp45Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Usp45Ratpeptidase activity enablesIEAUniProtKB-KW:KW-06451600115GO_REF:0000043UniProtGO_REF:0000043
Usp45Ratprotein binding enablesISOUSP45 (Homo sapiens)1624291UniProtKB:P07992 more ...RGDPMID:25538220 and PMID:30258100
Usp45Ratprotein binding enablesISOUsp45 (Mus musculus)1624291PR:P07903 PMID:25538220RGDPMID:25538220
Usp45Ratzinc ion binding enablesIEAInterPro:IPR0016071600115GO_REF:0000002InterProGO_REF:0000002
Usp45Ratzinc ion binding enablesIEAUniProtKB-KW:KW-08631600115GO_REF:0000043UniProtGO_REF:0000043
1 to 13 of 13 rows


#
Reference Title
Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:14715245   PMID:25538220   PMID:30573563  



Usp45
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8540,115,394 - 40,188,861 (+)NCBIGRCr8
mRatBN7.2535,318,621 - 35,392,090 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl535,318,635 - 35,389,420 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx537,442,950 - 37,516,428 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0539,035,678 - 39,109,156 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0538,975,187 - 39,048,666 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0535,916,763 - 35,984,525 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl535,916,804 - 35,984,524 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0540,573,111 - 40,639,487 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4536,517,213 - 36,590,986 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1536,502,821 - 36,587,983 (+)NCBI
Celera534,335,326 - 34,403,408 (+)NCBICelera
Cytogenetic Map5q21NCBI
USP45
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38699,432,325 - 99,517,846 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl699,432,325 - 99,521,728 (-)EnsemblGRCh38hg38GRCh38
GRCh37699,880,201 - 99,963,299 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36699,986,903 - 100,069,973 (-)NCBINCBI36Build 36hg18NCBI36
Celera6100,524,338 - 100,607,389 (-)NCBICelera
Cytogenetic Map6q16.2NCBI
HuRef697,320,605 - 97,403,620 (-)NCBIHuRef
CHM1_16100,143,216 - 100,226,233 (-)NCBICHM1_1
T2T-CHM13v2.06100,606,672 - 100,692,182 (-)NCBIT2T-CHM13v2.0
Usp45
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39421,767,161 - 21,837,872 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl421,767,156 - 21,837,872 (+)EnsemblGRCm39 Ensembl
GRCm38421,767,161 - 21,837,872 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl421,767,156 - 21,837,872 (+)EnsemblGRCm38mm10GRCm38
MGSCv37421,703,417 - 21,765,019 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36421,867,134 - 21,928,707 (+)NCBIMGSCv36mm8
Celera421,521,282 - 21,582,575 (+)NCBICelera
Cytogenetic Map4A3NCBI
cM Map48.93NCBI
Usp45
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541125,316,535 - 25,378,573 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541125,315,536 - 25,375,283 (-)NCBIChiLan1.0ChiLan1.0
USP45
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25119,479,099 - 119,562,643 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16117,357,233 - 117,443,835 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0697,273,498 - 97,356,749 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16101,155,903 - 101,239,145 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6101,155,903 - 101,238,682 (-)Ensemblpanpan1.1panPan2
USP45
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11257,637,890 - 57,706,562 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1257,642,515 - 57,706,511 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1257,396,662 - 57,468,813 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01258,460,557 - 58,533,263 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1258,500,488 - 58,533,253 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11257,817,618 - 57,889,705 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01257,662,704 - 57,736,494 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01257,907,902 - 57,981,807 (-)NCBIUU_Cfam_GSD_1.0
Usp45
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494692,576,117 - 92,663,981 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366511,037,804 - 1,119,399 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366511,031,328 - 1,119,344 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
USP45
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl166,387,608 - 66,454,737 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1166,387,616 - 66,454,806 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2175,067,349 - 75,131,522 (-)NCBISscrofa10.2Sscrofa10.2susScr3
USP45
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11374,368,043 - 74,434,884 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1374,362,564 - 74,438,133 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604046,695,092 - 46,768,332 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Usp45
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248105,508,882 - 5,574,395 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248105,508,912 - 5,574,233 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Usp45
253 total Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
5 35966303 35966304 A C snv SR/JrHsd (MCW) View more Information

Predicted Target Of
Summary Value
Count of predictions:398
Count of miRNA genes:228
Interacting mature miRNAs:273
Transcripts:ENSRNOT00000066043
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 27 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)5894822853948228Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat

1 to 10 of 27 rows
AU015084  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2535,320,665 - 35,320,777 (+)MAPPERmRatBN7.2
Rnor_6.0535,918,816 - 35,918,927NCBIRnor6.0
Rnor_5.0540,575,342 - 40,575,453UniSTSRnor5.0
RGSC_v3.4536,519,201 - 36,519,312UniSTSRGSC3.4
Celera534,337,357 - 34,337,468UniSTS
Cytogenetic Map5q21UniSTS
BF399437  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2535,371,967 - 35,372,128 (+)MAPPERmRatBN7.2
Rnor_6.0535,967,091 - 35,967,251NCBIRnor6.0
Rnor_5.0540,622,096 - 40,622,256UniSTSRnor5.0
RGSC_v3.4536,573,544 - 36,573,704UniSTSRGSC3.4
Celera534,386,072 - 34,386,232UniSTS
RH 3.4 Map5166.0UniSTS
Cytogenetic Map5q21UniSTS
AI843191  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2535,388,965 - 35,389,062 (+)MAPPERmRatBN7.2
mRatBN7.2753,916,905 - 53,917,002 (-)MAPPERmRatBN7.2
mRatBN7.2535,388,965 - 35,389,062 (-)MAPPERmRatBN7.2
mRatBN7.2753,916,905 - 53,917,002 (+)MAPPERmRatBN7.2
Rnor_6.0761,350,948 - 61,351,044NCBIRnor6.0
Rnor_6.0535,984,070 - 35,984,166NCBIRnor6.0
Rnor_5.0761,347,169 - 61,347,265UniSTSRnor5.0
Rnor_5.0540,639,032 - 40,639,128UniSTSRnor5.0
RGSC_v3.4536,590,532 - 36,590,628UniSTSRGSC3.4
RGSC_v3.4757,635,321 - 57,635,417UniSTSRGSC3.4
Celera534,402,954 - 34,403,050UniSTS
Cytogenetic Map5q21UniSTS
RH137368  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2753,916,654 - 53,916,873 (+)MAPPERmRatBN7.2
mRatBN7.2535,389,094 - 35,389,313 (-)MAPPERmRatBN7.2
mRatBN7.2753,916,654 - 53,916,873 (-)MAPPERmRatBN7.2
mRatBN7.2535,389,094 - 35,389,313 (+)MAPPERmRatBN7.2
Rnor_6.0761,350,697 - 61,350,915NCBIRnor6.0
Rnor_6.0535,984,199 - 35,984,417NCBIRnor6.0
Rnor_5.0761,346,918 - 61,347,136UniSTSRnor5.0
Rnor_5.0540,639,161 - 40,639,379UniSTSRnor5.0
RGSC_v3.4536,590,661 - 36,590,879UniSTSRGSC3.4
RGSC_v3.4757,635,070 - 57,635,288UniSTSRGSC3.4
Celera534,403,083 - 34,403,301UniSTS
RH 3.4 Map5165.5UniSTS
Cytogenetic Map5q21UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000066043   ⟹   ENSRNOP00000060364
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl535,318,635 - 35,389,420 (+)Ensembl
Rnor_6.0 Ensembl535,916,804 - 35,984,524 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083132   ⟹   ENSRNOP00000073155
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl535,318,635 - 35,389,420 (+)Ensembl
Rnor_6.0 Ensembl535,916,819 - 35,981,378 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108204   ⟹   ENSRNOP00000092813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl535,318,635 - 35,389,420 (+)Ensembl
RefSeq Acc Id: NM_001395561   ⟹   NP_001382490
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8540,115,409 - 40,188,861 (+)NCBI
mRatBN7.2535,318,635 - 35,392,090 (+)NCBI
RefSeq Acc Id: XM_006237939   ⟹   XP_006238001
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8540,115,426 - 40,186,192 (+)NCBI
mRatBN7.2535,318,640 - 35,392,090 (+)NCBI
Rnor_6.0535,916,777 - 35,984,525 (+)NCBI
Rnor_5.0540,573,111 - 40,639,487 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006237940   ⟹   XP_006238002
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8540,115,394 - 40,186,192 (+)NCBI
mRatBN7.2535,318,621 - 35,392,090 (+)NCBI
Rnor_6.0535,916,764 - 35,984,525 (+)NCBI
Rnor_5.0540,573,111 - 40,639,487 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006237941   ⟹   XP_006238003
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8540,115,394 - 40,186,192 (+)NCBI
mRatBN7.2535,318,621 - 35,392,090 (+)NCBI
Rnor_6.0535,916,763 - 35,984,525 (+)NCBI
Rnor_5.0540,573,111 - 40,639,487 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039109812   ⟹   XP_038965740
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8540,115,426 - 40,186,192 (+)NCBI
mRatBN7.2535,318,640 - 35,392,090 (+)NCBI
RefSeq Acc Id: XM_039109813   ⟹   XP_038965741
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8540,137,292 - 40,186,192 (+)NCBI
mRatBN7.2535,340,516 - 35,392,090 (+)NCBI
RefSeq Acc Id: XP_006238003   ⟸   XM_006237941
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AG99 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238002   ⟸   XM_006237940
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006238001   ⟸   XM_006237939
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K4S7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000060364   ⟸   ENSRNOT00000066043
Ensembl Acc Id: ENSRNOP00000073155   ⟸   ENSRNOT00000083132
UBP-type   USP

Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K4S7-F1-model_v2 AlphaFold A0A0G2K4S7 1-813 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693596
Promoter ID:EPDNEW_R4121
Type:multiple initiation site
Name:Usp45_1
Description:ubiquitin specific peptidase 45
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0535,916,813 - 35,916,873EPDNEW


1 to 32 of 32 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-41814 BioCyc
Ensembl Genes ENSRNOG00000008688 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066043.3 UniProtKB/TrEMBL
  ENSRNOT00000083132 ENTREZGENE
  ENSRNOT00000083132.2 UniProtKB/TrEMBL
  ENSRNOT00000108204 ENTREZGENE
  ENSRNOT00000108204.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
  Cysteine proteinases UniProtKB/TrEMBL
InterPro Papain_like_cys_pep_sf UniProtKB/TrEMBL
  Pept_C19ubi-hydrolase_C_CS UniProtKB/TrEMBL
  Peptidase_C19 UniProtKB/TrEMBL
  Ub_carboxyl-term_hydrolase UniProtKB/TrEMBL
  UCH/PAN2 UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_UBP UniProtKB/TrEMBL
NCBI Gene 313098 ENTREZGENE
PANTHER UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UniProtKB/TrEMBL
  UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 45 UniProtKB/TrEMBL
Pfam UCH UniProtKB/TrEMBL
  zf-UBP UniProtKB/TrEMBL
PhenoGen Usp45 PhenoGen
PROSITE UCH_2_1 UniProtKB/TrEMBL
  UCH_2_2 UniProtKB/TrEMBL
  UCH_2_3 UniProtKB/TrEMBL
  ZF_UBP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008688 RatGTEx
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
  SSF54001 UniProtKB/TrEMBL
UniProt A0A0G2K4S7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AG99 ENTREZGENE, UniProtKB/TrEMBL
  D3ZM59_RAT UniProtKB/TrEMBL
1 to 32 of 32 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Usp45  ubiquitin specific peptidase 45  Usp45  ubiquitin specific petidase 45   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Usp45  ubiquitin specific petidase 45   Usp45_predicted  ubiquitin specific petidase 45 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Usp45_predicted  ubiquitin specific petidase 45 (predicted)    ubiquitin specific protease 45 (predicted)  Name updated 1299863 APPROVED
2005-01-12 Usp45_predicted  ubiquitin specific protease 45 (predicted)      Symbol and Name status set to approved 70820 APPROVED