Gsto2 (glutathione S-transferase omega 2) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Gsto2 (glutathione S-transferase omega 2) Rattus norvegicus
Analyze
Symbol: Gsto2
Name: glutathione S-transferase omega 2
RGD ID: 1310764
Description: Predicted to enable glutathione dehydrogenase (ascorbate) activity; glutathione transferase activity; and identical protein binding activity. Predicted to be involved in several processes, including L-ascorbic acid metabolic process; cellular response to arsenic-containing substance; and glutathione metabolic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and asthma. Orthologous to human GSTO2 (glutathione S-transferase omega 2); PARTICIPATES IN glutathione conjugation pathway; glutathione metabolic pathway; glutathione synthase deficiency pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; all-trans-retinoic acid; atrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glutathione S-transferase omega 2-2; glutathione S-transferase omega-2; glutathione-dependent dehydroascorbate reductase; GSTO 2-2; GSTO-2; LOC103690044; LOC309465; MMA(V) reductase; monomethylarsonic acid reductase
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81256,673,376 - 256,695,154 (+)NCBIGRCr8
mRatBN7.21246,731,314 - 246,757,592 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1246,732,089 - 246,753,866 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1254,859,384 - 254,881,207 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01261,552,355 - 261,574,175 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01254,202,420 - 254,224,048 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01267,617,517 - 267,640,455 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1267,607,416 - 267,640,455 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1271,229,036 - 271,243,517 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01275,050,163 - 275,072,303 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01278,656,945 - 278,671,426 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41253,239,392 - 253,275,110 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11253,504,135 - 253,539,851 (+)NCBI
Celera1242,496,974 - 242,517,641 (+)NCBICelera
Cytogenetic Map1q54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gsto2RatAlzheimer's disease no_associationISOGSTO2 (Homo sapiens)5490514DNA:polymorphism:promoter: -183 A>G (rs2297235)(human)RGD 
Gsto2RatAlzheimer's disease onsetISOGSTO2 (Homo sapiens)1358651DDNA:polymorphism: : -183 A>G (rs2297235)(human)RGD 
Gsto2Ratasthma susceptibilityISOGSTO2 (Homo sapiens)5490988DNA:polymorphism:exon:p. N142D (human)RGD 
Gsto2RatParkinson's disease susceptibilityISOGSTO2 (Homo sapiens)5490299DNA:polymorphism: : -183 A>G (rs2297235)(human)RGD 
Gsto2RatParkinson's disease onsetISOGSTO2 (Homo sapiens)1358651DDNA:polymorphism: : -183 A>G (rs2297235)(human)RGD 
Object Symbol
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Evidence
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Reference
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Original Reference(s)
Gsto2Ratdesmoplastic/nodular medulloblastoma  ISOGSTO2 (Homo sapiens)8554872ClinVar Annotator: match by term: Desmoplastic/nodular medulloblastomaClinVarPMID:12068298
Object Symbol
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Original Reference(s)
Gsto2Raturinary bladder cancer  ISOGSTO2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22306368

1 to 20 of 84 rows

  
Object Symbol
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Reference
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Original Reference(s)
Gsto2Rat1,2-dimethylhydrazine decreases expressionISOGsto2 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of GSTO2 mRNACTDPMID:22206623
Gsto2Rat17beta-estradiol affects expressionISOGSTO2 (Homo sapiens)6480464Estradiol affects the expression of GSTO2 mRNACTDPMID:22574217
Gsto2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of GSTO2 mRNACTDPMID:21215274 and PMID:33387578
Gsto2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOGsto2 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of GSTO2 mRNACTDPMID:21570461 and PMID:26377647
Gsto2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOGSTO2 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in decreased expression of GSTO2 mRNACTDPMID:20106945 and PMID:21632981
Gsto2Rat4-nitrophenol increases expressionISOGsto2 (Mus musculus)64804644-nitrophenol results in increased expression of GSTO2 mRNACTDPMID:34673133
Gsto2Rat5-aza-2'-deoxycytidine affects expressionISOGSTO2 (Homo sapiens)6480464Decitabine affects the expression of GSTO2 mRNACTDPMID:23300844
Gsto2Ratacrylamide decreases expressionISOGsto2 (Mus musculus)6480464Acrylamide results in decreased expression of GSTO2 mRNACTDPMID:30807115
Gsto2Rataflatoxin B1 decreases methylationISOGSTO2 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of GSTO2 geneCTDPMID:27153756
Gsto2Ratall-trans-retinoic acid decreases expressionEXP 6480464Tretinoin results in decreased expression of GSTO2 mRNACTDPMID:30267739
Gsto2Ratamiodarone increases expressionISOGSTO2 (Homo sapiens)6480464Amiodarone results in increased expression of GSTO2 mRNACTDPMID:19774075
Gsto2Ratantirheumatic drug decreases expressionISOGSTO2 (Homo sapiens)6480464Antirheumatic Agents results in decreased expression of GSTO2 mRNACTDPMID:24449571
Gsto2Ratarsane affects response to substanceISOGSTO2 (Homo sapiens)6480464GSTO2 gene polymorphism affects the susceptibility to Arsenic and GSTO2 gene SNP affects the susceptibility to ArsenicCTDPMID:20045512 and PMID:21094982
Gsto2Ratarsane increases response to substanceISOGSTO2 (Homo sapiens)6480464GSTO2 gene SNP results in increased susceptibility to ArsenicCTDPMID:29323258
Gsto2Ratarsane multiple interactionsISOGSTO2 (Homo sapiens)6480464[Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of GSTO2 mRNA more ...CTDPMID:21605854 more ...
Gsto2Ratarsane increases metabolic processingISOGSTO2 (Homo sapiens)6480464GSTO2 protein results in increased metabolism of ArsenicCTDPMID:16638819 and PMID:18414634
Gsto2Ratarsane affects metabolic processingISOGSTO2 (Homo sapiens)6480464GSTO2 gene SNP affects the metabolism of ArsenicCTDPMID:21094982
Gsto2Ratarsenic atom multiple interactionsISOGSTO2 (Homo sapiens)6480464[Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of GSTO2 mRNA more ...CTDPMID:21605854 more ...
Gsto2Ratarsenic atom increases response to substanceISOGSTO2 (Homo sapiens)6480464GSTO2 gene SNP results in increased susceptibility to ArsenicCTDPMID:29323258
Gsto2Ratarsenic atom increases metabolic processingISOGSTO2 (Homo sapiens)6480464GSTO2 protein results in increased metabolism of ArsenicCTDPMID:16638819 and PMID:18414634

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Biological Process
1 to 13 of 13 rows

  
Object Symbol
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Reference
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Source
Original Reference(s)
Gsto2Ratcellular oxidant detoxification involved_inIEAGO:00451741600115GO_REF:0000108GOCGO_REF:0000108
Gsto2Ratcellular response to arsenic-containing substance involved_inISSUniProtKB:Q9H4Y51600115GO_REF:0000024UniProtGO_REF:0000024
Gsto2Ratcellular response to arsenic-containing substance involved_inISOGSTO2 (Homo sapiens)1624291 PMID:15970797RGDPMID:15970797
Gsto2Ratcellular response to arsenic-containing substance involved_inIEAUniProtKB:Q9H4Y5 and ensembl:ENSP000003450231600115GO_REF:0000107EnsemblGO_REF:0000107
Gsto2Ratglutathione metabolic process involved_inIEAUniRule:UR0015537741600115GO_REF:0000104UniProtGO_REF:0000104
Gsto2Ratglutathione metabolic process involved_inIBAFB:FBgn0035904 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gsto2RatL-ascorbic acid metabolic process involved_inISSUniProtKB:Q9H4Y51600115GO_REF:0000024UniProtGO_REF:0000024
Gsto2RatL-ascorbic acid metabolic process involved_inIBAPANTHER:PTN000136799 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gsto2RatL-ascorbic acid metabolic process involved_inISOGSTO2 (Homo sapiens)1624291 PMID:15970797RGDPMID:15970797
Gsto2RatL-ascorbic acid metabolic process involved_inIEAUniProtKB:Q9H4Y5 and ensembl:ENSP000003450231600115GO_REF:0000107EnsemblGO_REF:0000107
Gsto2Ratxenobiotic metabolic process involved_inISSUniProtKB:Q9H4Y51600115GO_REF:0000024UniProtGO_REF:0000024
Gsto2Ratxenobiotic metabolic process involved_inIEAUniProtKB:Q9H4Y5 and ensembl:ENSP000003450231600115GO_REF:0000107EnsemblGO_REF:0000107
Gsto2Ratxenobiotic metabolic process involved_inISOGSTO2 (Homo sapiens)1624291 PMID:15970797RGDPMID:15970797
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Cellular Component

  
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Original Reference(s)
Gsto2Ratcytoplasm located_inIEAInterPro:IPR0054421600115GO_REF:0000002InterProGO_REF:0000002
Gsto2Ratcytoplasm is_active_inIBAFB:FBgn0035906 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function
1 to 20 of 23 rows

  
Object Symbol
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Original Reference(s)
Gsto2Ratglutathione dehydrogenase (ascorbate) activity enablesISOGSTO2 (Homo sapiens)1624291 PMID:15970797RGDPMID:15970797
Gsto2Ratglutathione dehydrogenase (ascorbate) activity enablesIEAUniProtKB:Q9H4Y5 and ensembl:ENSP000003450231600115GO_REF:0000107EnsemblGO_REF:0000107
Gsto2Ratglutathione dehydrogenase (ascorbate) activity enablesIEAEC:1.8.5.11600115GO_REF:0000003UniProtGO_REF:0000003
Gsto2Ratglutathione dehydrogenase (ascorbate) activity enablesIBAFB:FBgn0035904 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gsto2Ratglutathione dehydrogenase (ascorbate) activity enablesIEAUniRule:UR0015537741600115GO_REF:0000104UniProtGO_REF:0000104
Gsto2Ratglutathione dehydrogenase (ascorbate) activity enablesIEAARBA:ARBA000284171600115GO_REF:0000117UniProtGO_REF:0000117
Gsto2Ratglutathione dehydrogenase (ascorbate) activity enablesIEARHEA:244241600115GO_REF:0000116RHEAGO_REF:0000116
Gsto2Ratglutathione dehydrogenase (ascorbate) activity enablesISSUniProtKB:Q9H4Y51600115GO_REF:0000024UniProtGO_REF:0000024
Gsto2Ratglutathione transferase activity enablesIEAUniRule:UR0015537741600115GO_REF:0000104UniProtGO_REF:0000104
Gsto2Ratglutathione transferase activity enablesIBAFB:FBgn0035904 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gsto2Ratglutathione transferase activity enablesIEAEC:2.5.1.181600115GO_REF:0000003UniProtGO_REF:0000003
Gsto2Ratglutathione transferase activity enablesIEAInterPro:IPR0054421600115GO_REF:0000002InterProGO_REF:0000002
Gsto2Ratidentical protein binding enablesISOGSTO2 (Homo sapiens)1624291UniProtKB:Q9H4Y5 more ...RGDPMID:25416956 and PMID:32296183
Gsto2Ratidentical protein binding enablesIEAUniProtKB:Q9H4Y5 and ensembl:ENSP000003450231600115GO_REF:0000107EnsemblGO_REF:0000107
Gsto2Ratmethylarsonate reductase activity enablesIEARHEA:159691600115GO_REF:0000116RHEAGO_REF:0000116
Gsto2Ratmethylarsonate reductase activity enablesIEAUniRule:UR0015537741600115GO_REF:0000104UniProtGO_REF:0000104
Gsto2Ratmethylarsonate reductase activity enablesIEAEC:1.20.4.21600115GO_REF:0000003UniProtGO_REF:0000003
Gsto2Ratoxidoreductase activity enablesISSUniProtKB:Q9H4Y51600115GO_REF:0000024UniProtGO_REF:0000024
Gsto2Ratoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
Gsto2Ratoxidoreductase activity enablesIEAUniProtKB:Q9H4Y5 and ensembl:ENSP000003450231600115GO_REF:0000107EnsemblGO_REF:0000107
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RGD Manual Annotations


  
Object Symbol
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Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Gsto2Ratglutathione conjugation pathway  ISOGSTO2 (Homo sapiens)1358120 RGD 

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Gsto2Ratglutathione metabolic pathway  IEA 6907045 KEGGrno:00480
Gsto2Ratphase I biotransformation pathway via cytochrome P450  IEA 6907045 KEGGrno:00980
Gsto2Ratphase I biotransformation pathway via cytochrome P450  IEA 6907045 KEGGrno:00982

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#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease. Li YJ, etal., Hum Mol Genet 2003 Dec 15;12(24):3259-67. Epub 2003 Oct 21.
3. Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease. Ozturk A, etal., Neurobiol Aging. 2005 Aug-Sep;26(8):1161-5. Epub 2004 Dec 18.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
6. GSTA1, GSTO1 and GSTO2 gene polymorphisms in Italian asthma patients. Polimanti R, etal., Clin Exp Pharmacol Physiol. 2010 Aug;37(8):870-2. Epub 2010 Mar 30.
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Glutathione S-transferase: genetics and role in toxicology. Strange RC, etal., Toxicol Lett 2000 Mar 15;112-113:357-63.
10. Glutathione S-transferase mu, omega, pi, and theta class variants and smoking in Parkinson's disease. Wahner AD, etal., Neurosci Lett. 2007 Feb 21;413(3):274-8. Epub 2006 Dec 27.
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PMID:12477932   PMID:15489334   PMID:15970797   PMID:19056867   PMID:25416956  



Gsto2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81256,673,376 - 256,695,154 (+)NCBIGRCr8
mRatBN7.21246,731,314 - 246,757,592 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1246,732,089 - 246,753,866 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1254,859,384 - 254,881,207 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01261,552,355 - 261,574,175 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01254,202,420 - 254,224,048 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01267,617,517 - 267,640,455 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1267,607,416 - 267,640,455 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1271,229,036 - 271,243,517 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01275,050,163 - 275,072,303 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01278,656,945 - 278,671,426 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41253,239,392 - 253,275,110 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11253,504,135 - 253,539,851 (+)NCBI
Celera1242,496,974 - 242,517,641 (+)NCBICelera
Cytogenetic Map1q54NCBI
GSTO2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810104,269,184 - 104,304,950 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10104,268,873 - 104,304,950 (+)EnsemblGRCh38hg38GRCh38
GRCh3710106,028,942 - 106,064,708 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610106,018,621 - 106,049,166 (+)NCBINCBI36Build 36hg18NCBI36
Celera1099,769,465 - 99,799,992 (+)NCBICelera
Cytogenetic Map10q25.1NCBI
HuRef1099,660,411 - 99,690,935 (+)NCBIHuRef
CHM1_110106,312,517 - 106,343,025 (+)NCBICHM1_1
T2T-CHM13v2.010105,157,320 - 105,193,113 (+)NCBIT2T-CHM13v2.0
Gsto2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391947,853,879 - 47,874,747 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1947,853,973 - 47,874,763 (+)EnsemblGRCm39 Ensembl
GRCm381947,865,438 - 47,886,308 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1947,865,534 - 47,886,324 (+)EnsemblGRCm38mm10GRCm38
MGSCv371947,940,284 - 47,960,795 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361947,919,114 - 47,939,616 (+)NCBIMGSCv36mm8
Celera1948,626,289 - 48,646,818 (+)NCBICelera
Cytogenetic Map19D1NCBI
cM Map1940.41NCBI
GSTO2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28116,153,709 - 116,185,499 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110116,159,053 - 116,190,832 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010100,868,109 - 100,901,013 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110104,326,174 - 104,357,604 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10104,326,175 - 104,357,604 (+)Ensemblpanpan1.1panPan2
GSTO2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12816,580,250 - 16,604,977 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2816,586,777 - 16,604,976 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2816,752,960 - 16,777,367 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02817,058,781 - 17,083,140 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2817,064,468 - 17,083,139 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12816,606,330 - 16,630,694 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02816,635,026 - 16,659,336 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02816,773,733 - 16,798,027 (+)NCBIUU_Cfam_GSD_1.0
Gsto2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721330,304,171 - 30,322,114 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366001,907,517 - 1,925,235 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366001,907,396 - 1,925,256 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GSTO2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14115,217,879 - 115,251,435 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114115,218,179 - 115,242,377 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214125,187,089 - 125,209,743 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GSTO2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1997,319,695 - 97,348,406 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl997,325,215 - 97,349,422 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604858,438,455 - 58,468,894 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

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Variants in Gsto2
244 total Variants

Predicted Target Of
Summary Value
Count of predictions:181
Count of miRNA genes:110
Interacting mature miRNAs:113
Transcripts:ENSRNOT00000017186
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 47 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat

1 to 10 of 47 rows
BF387299  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21246,753,680 - 246,753,860 (+)MAPPERmRatBN7.2
Rnor_6.01271,243,329 - 271,243,508NCBIRnor6.0
Rnor_6.01267,640,267 - 267,640,446NCBIRnor6.0
Rnor_5.01278,671,238 - 278,671,417UniSTSRnor5.0
Rnor_5.01275,072,115 - 275,072,294UniSTSRnor5.0
RGSC_v3.41253,274,922 - 253,275,101UniSTSRGSC3.4
Celera1242,517,453 - 242,517,632UniSTS
RH 3.4 Map11623.8UniSTS
Cytogenetic Map1q54UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
15 11 55 139 119 114 71 31 71 12 261 121 107 46 79 43



Ensembl Acc Id: ENSRNOT00000017186   ⟹   ENSRNOP00000017186
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1246,732,089 - 246,753,866 (+)Ensembl
Rnor_6.0 Ensembl1267,618,248 - 267,640,455 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000064023   ⟹   ENSRNOP00000060669
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1246,732,089 - 246,753,866 (+)Ensembl
Rnor_6.0 Ensembl1271,229,036 - 271,243,517 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076251   ⟹   ENSRNOP00000068075
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1267,618,565 - 267,627,827 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076751
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1267,618,581 - 267,638,938 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087894   ⟹   ENSRNOP00000068891
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1267,607,416 - 267,640,402 (+)Ensembl
RefSeq Acc Id: NM_001012071   ⟹   NP_001012071
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81256,673,376 - 256,695,154 (+)NCBI
mRatBN7.21246,732,089 - 246,753,869 (+)NCBI
Rnor_6.01267,618,248 - 267,640,455 (+)NCBI
Rnor_5.01278,656,945 - 278,671,426 (+)NCBI
RGSC_v3.41253,239,392 - 253,275,110 (+)RGD
Celera1242,496,974 - 242,517,641 (+)RGD
Sequence:
RefSeq Acc Id: NM_001419742   ⟹   NP_001406671
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81256,673,648 - 256,695,154 (+)NCBI
mRatBN7.21246,732,361 - 246,753,869 (+)NCBI
RefSeq Acc Id: XM_006231590   ⟹   XP_006231652
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81256,673,613 - 256,695,154 (+)NCBI
mRatBN7.21246,732,325 - 246,757,592 (+)NCBI
Rnor_6.01267,618,484 - 267,640,455 (+)NCBI
Rnor_5.01275,050,163 - 275,072,303 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006231592   ⟹   XP_006231654
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81256,673,427 - 256,695,154 (+)NCBI
mRatBN7.21246,731,314 - 246,757,592 (+)NCBI
Rnor_6.01267,617,517 - 267,640,455 (+)NCBI
Rnor_5.01275,050,163 - 275,072,303 (+)NCBI
Sequence:
1 to 9 of 9 rows
Protein RefSeqs NP_001012071 (Get FASTA)   NCBI Sequence Viewer  
  NP_001406671 (Get FASTA)   NCBI Sequence Viewer  
  XP_006231652 (Get FASTA)   NCBI Sequence Viewer  
  XP_006231654 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH79295 (Get FASTA)   NCBI Sequence Viewer  
  ACI32123 (Get FASTA)   NCBI Sequence Viewer  
  EDL94394 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017186
GenBank Protein Q6AXV9 (Get FASTA)   NCBI Sequence Viewer  
1 to 9 of 9 rows
RefSeq Acc Id: NP_001012071   ⟸   NM_001012071
- UniProtKB: Q6AXV9 (UniProtKB/Swiss-Prot),   B6DYQ6 (UniProtKB/TrEMBL),   A0A8L2Q9F9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231654   ⟸   XM_006231592
- Peptide Label: isoform X1
- UniProtKB: Q6AXV9 (UniProtKB/Swiss-Prot),   B6DYQ6 (UniProtKB/TrEMBL),   A0A8L2Q9F9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231652   ⟸   XM_006231590
- Peptide Label: isoform X1
- UniProtKB: Q6AXV9 (UniProtKB/Swiss-Prot),   B6DYQ6 (UniProtKB/TrEMBL),   A0A8L2Q9F9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068891   ⟸   ENSRNOT00000087894
Ensembl Acc Id: ENSRNOP00000017186   ⟸   ENSRNOT00000017186
GST C-terminal   GST N-terminal

Name Modeler Protein Id AA Range Protein Structure
AF-Q6AXV9-F1-model_v2 AlphaFold Q6AXV9 1-248 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690983
Promoter ID:EPDNEW_R1507
Type:initiation region
Name:Gsto2_1
Description:glutathione S-transferase omega 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01267,618,506 - 267,618,566EPDNEW


1 to 36 of 36 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-55462 BioCyc
Ensembl Genes ENSRNOG00000012801 Ensembl
  ENSRNOG00000049964 Ensembl
  ENSRNOG00000069697 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000017186 ENTREZGENE
Gene3D-CATH 1.20.1050.10 UniProtKB/Swiss-Prot
  Glutaredoxin UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7134485 IMAGE-MGC_LOAD
InterPro Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot
  Glutathione_S-Trfase UniProtKB/Swiss-Prot
  Glutathione_S-Trfase_N UniProtKB/Swiss-Prot
  GST_C UniProtKB/Swiss-Prot
  GST_omega UniProtKB/Swiss-Prot
  GST_Omega/HSP26 UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:309465 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94431 IMAGE-MGC_LOAD
NCBI Gene 309465 ENTREZGENE
PANTHER GLUTATHIONE S-TRANSFERASE OMEGA-2 UniProtKB/Swiss-Prot
  PTHR43968 UniProtKB/Swiss-Prot
Pfam GST_C_3 UniProtKB/Swiss-Prot
  GST_N_2 UniProtKB/Swiss-Prot
PhenoGen Gsto2 PhenoGen
PRINTS GSTRNSFRASEO UniProtKB/Swiss-Prot
PROSITE GST_CTER UniProtKB/Swiss-Prot
  GST_NTER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012801 RatGTEx
  ENSRNOG00000049964 RatGTEx
  ENSRNOG00000069697 RatGTEx
Superfamily-SCOP SSF47616 UniProtKB/Swiss-Prot
  SSF52833 UniProtKB/Swiss-Prot
UniProt A0A8L2Q9F9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QUB5_RAT UniProtKB/TrEMBL
  B6DYQ6 ENTREZGENE, UniProtKB/TrEMBL
  GSTO2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 36 of 36 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Gsto2  glutathione S-transferase omega 2  LOC103690044  glutathione S-transferase omega-2  Data merged from RGD:9449876 737654 PROVISIONAL
2014-08-25 LOC103690044  glutathione S-transferase omega-2      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-12-06 Gsto2  glutathione S-transferase omega 2  Gsto2_predicted  glutathione S-transferase omega 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Gsto2_predicted  glutathione S-transferase omega 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED