Cops5 (COP9 signalosome subunit 5) - Rat Genome Database

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Gene: Cops5 (COP9 signalosome subunit 5) Rattus norvegicus
Analyze
Symbol: Cops5
Name: COP9 signalosome subunit 5
RGD ID: 1310301
Description: Predicted to enable enzyme binding activity; macrophage migration inhibitory factor binding activity; and ubiquitin-like protein peptidase activity. Predicted to be involved in several processes, including regulation of DNA-templated transcription; regulation of apoptotic process; and regulation of intracellular signal transduction. Predicted to be located in several cellular components, including nucleoplasm; perinuclear region of cytoplasm; and synaptic vesicle. Predicted to be part of COP9 signalosome. Predicted to be active in cytoplasm. Orthologous to human COPS5 (COP9 signalosome subunit 5); PARTICIPATES IN hypoxia inducible factor pathway; INTERACTS WITH 2,4-dinitrotoluene; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: COP9 (constitutive photomorphogenic) homolog, subunit 5; COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana); COP9 constitutive photomorphogenic homolog subunit 5; COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis); COP9 signalosome complex subunit 5; LOC312916; MGC112728
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8513,975,198 - 13,993,391 (+)NCBIGRCr8
mRatBN7.259,192,233 - 9,210,498 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl59,192,100 - 9,210,731 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx511,344,273 - 11,362,693 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0512,971,568 - 12,989,792 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0512,678,930 - 12,697,346 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.058,876,090 - 8,894,345 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl58,876,044 - 8,894,339 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0513,684,111 - 13,702,378 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.458,709,214 - 8,727,277 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.158,709,213 - 8,727,277 (+)NCBI
Celera58,703,366 - 8,721,421 (+)NCBICelera
Cytogenetic Map5q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
Cops5RatExperimental Liver Neoplasms  IEP 11354707protein:increased expression:liver (rat)RGD 
Cops5Rathepatocellular carcinoma severityISOCOPS5 (Homo sapiens)11354707protein:increased expression:liver (human)RGD 
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Original Reference(s)
Cops5RatJoubert syndrome 21  ISOCOPS5 (Homo sapiens)8554872ClinVar Annotator: match by term: Joubert syndrome 21ClinVarPMID:28492532
Object Symbol
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Original Reference(s)
Cops5Rathepatocellular carcinoma  ISOCOPS5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20698225
Cops5RatStevens-Johnson syndrome  ISOCOPS5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25811541

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Original Reference(s)
Cops5Rat(1->4)-beta-D-glucan multiple interactionsISOCops5 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of COPS5 mRNACTDPMID:36331819
Cops5Rat1,2-dimethylhydrazine increases expressionISOCops5 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of COPS5 mRNACTDPMID:22206623
Cops5Rat1,2-dimethylhydrazine multiple interactionsISOCops5 (Mus musculus)6480464Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of COPS5 mRNA]CTDPMID:22206623
Cops5Rat17beta-estradiol increases expressionISOCops5 (Mus musculus)6480464Estradiol results in increased expression of COPS5 mRNACTDPMID:39298647
Cops5Rat2,2',4,4'-Tetrabromodiphenyl ether affects expressionISOCops5 (Mus musculus)64804642 more ...CTDPMID:30294300
Cops5Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOCops5 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of COPS5 mRNACTDPMID:21570461
Cops5Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of COPS5 mRNACTDPMID:21346803
Cops5Rat2-methylcholine affects expressionISOCOPS5 (Homo sapiens)6480464beta-methylcholine affects the expression of COPS5 mRNACTDPMID:21179406
Cops5Rat4,4'-sulfonyldiphenol increases expressionISOCops5 (Mus musculus)6480464bisphenol S results in increased expression of COPS5 mRNACTDPMID:39298647
Cops5Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of COPS5 mRNACTDPMID:30047161
Cops5Ratamitrole increases expressionEXP 6480464Amitrole results in increased expression of COPS5 mRNACTDPMID:30047161
Cops5Ratamphetamine increases expressionISOCops5 (Mus musculus)6480464Amphetamine results in increased expression of COPS5 proteinCTDPMID:23459167
Cops5Ratantimycin A decreases expressionISOCOPS5 (Homo sapiens)6480464Antimycin A results in decreased expression of COPS5 mRNACTDPMID:33512557
Cops5Ratarsenous acid multiple interactionsISOCOPS5 (Homo sapiens)6480464[Arsenic Trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of COPS5 protein and Arsenic Trioxide results in decreased expression of and results in increased localization of COPS5 proteinCTDPMID:17077332 and PMID:20698225
Cops5Ratbenzo[a]pyrene increases expressionISOCops5 (Mus musculus)6480464Benzo(a)pyrene results in increased expression of COPS5 mRNACTDPMID:22228805
Cops5Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of COPS5 mRNACTDPMID:26982218
Cops5Ratbisphenol A decreases expressionISOCOPS5 (Homo sapiens)6480464bisphenol A results in decreased expression of COPS5 mRNACTDPMID:29275510
Cops5Ratbisphenol A increases expressionEXP 6480464bisphenol A results in increased expression of COPS5 mRNACTDPMID:25181051
Cops5Ratbisphenol AF increases expressionISOCOPS5 (Homo sapiens)6480464bisphenol AF results in increased expression of COPS5 proteinCTDPMID:34186270
Cops5RatC60 fullerene decreases expressionEXP 6480464fullerene C60 results in decreased expression of COPS5 mRNACTDPMID:19167457

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Biological Process
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Original Reference(s)
Cops5Ratexosomal secretion involved_inISOCOPS5 (Homo sapiens)1624291 PMID:19246649RGDPMID:19246649
Cops5Ratexosomal secretion involved_inIEAUniProtKB:Q92905 and ensembl:ENSP000003505121600115GO_REF:0000107EnsemblGO_REF:0000107
Cops5Ratnegative regulation of apoptotic process involved_inISOCOPS5 (Homo sapiens)1624291 PMID:20978819RGDPMID:20978819
Cops5Ratnegative regulation of apoptotic process involved_inIEAUniProtKB:Q92905 and ensembl:ENSP000003505121600115GO_REF:0000107EnsemblGO_REF:0000107
Cops5Ratpositive regulation of apoptotic process involved_inISOCOPS5 (Sus scrofa)1624291 PMID:24091666RGDPMID:24091666
Cops5Ratpositive regulation of DNA-binding transcription factor activity involved_inISOCOPS5 (Homo sapiens)1624291 PMID:20978819RGDPMID:20978819
Cops5Ratpositive regulation of transcription by RNA polymerase II involved_inISOCOPS5 (Homo sapiens)1624291 PMID:16410250RGDPMID:16410250
Cops5Ratpositive regulation of transcription by RNA polymerase II involved_inIEAUniProtKB:Q92905 and ensembl:ENSP000003505121600115GO_REF:0000107EnsemblGO_REF:0000107
Cops5Ratprotein deneddylation involved_inISOCOPS5 (Homo sapiens)1624291 PMID:19141280 and PMID:19214193RGDPMID:19141280 and PMID:19214193
Cops5Ratprotein deneddylation involved_inIEAUniProtKB:Q92905 and ensembl:ENSP000003505121600115GO_REF:0000107EnsemblGO_REF:0000107
Cops5Ratregulation of cell cycle involved_inIBAFB:FBgn0027053 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cops5Ratregulation of cell cycle acts_upstream_of_or_withinIEAUniProtKB:O35864 and ensembl:ENSMUSP000000270501600115GO_REF:0000107EnsemblGO_REF:0000107
Cops5Ratregulation of cell cycle acts_upstream_of_or_withinISOCops5 (Mus musculus)1624291MGI:3511260 PMID:15299027RGDPMID:15299027
Cops5Ratregulation of IRE1-mediated unfolded protein response involved_inISOCOPS5 (Homo sapiens)1624291 PMID:15234121RGDPMID:15234121
Cops5Ratregulation of IRE1-mediated unfolded protein response involved_inIEAUniProtKB:Q92905 and ensembl:ENSP000003505121600115GO_REF:0000107EnsemblGO_REF:0000107
Cops5Ratregulation of JNK cascade involved_inISOCOPS5 (Homo sapiens)1624291 PMID:16410250RGDPMID:16410250
Cops5Ratregulation of JNK cascade involved_inIEAUniProtKB:Q92905 and ensembl:ENSP000003505121600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Original Reference(s)
Cops5Ratchromatin located_inISOCOPS5 (Homo sapiens)1624291 PMID:20978819RGDPMID:20978819
Cops5Ratchromatin located_inIEAUniProtKB:Q92905 and ensembl:ENSP000003505121600115GO_REF:0000107EnsemblGO_REF:0000107
Cops5RatCOP9 signalosome part_ofISOCOPS5 (Homo sapiens)1624291 PMID:18850735 more ...RGDPMID:18850735 more ...
Cops5RatCOP9 signalosome part_ofIEAUniProtKB:Q92905 and ensembl:ENSP000003505121600115GO_REF:0000107EnsemblGO_REF:0000107
Cops5RatCOP9 signalosome part_ofIEAUniProtKB:O35864 and ensembl:ENSMUSP000000270501600115GO_REF:0000107EnsemblGO_REF:0000107
Cops5RatCOP9 signalosome part_ofISOCops5 (Mus musculus)1624291 PMID:9707402RGDPMID:9707402
Cops5RatCOP9 signalosome part_ofIBAFB:FBgn0027053 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cops5RatCOP9 signalosome part_ofIEAUniProtKB-KW:KW-07361600115GO_REF:0000043UniProtGO_REF:0000043
Cops5Ratcytoplasm located_inISOCOPS5 (Sus scrofa)1624291 PMID:24091666RGDPMID:24091666
Cops5Ratcytoplasm located_inIEAUniProtKB:Q92905 and ensembl:ENSP000003505121600115GO_REF:0000107EnsemblGO_REF:0000107
Cops5Ratcytoplasm located_inISOCOPS5 (Homo sapiens)1624291 PMID:16300740 more ...RGDPMID:16300740 more ...
Cops5Ratcytoplasm is_active_inIBAFB:FBgn0027053 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cops5Ratcytosol located_inISOCOPS5 (Homo sapiens)1624291 PMID:20978819RGDPMID:20978819
Cops5Ratcytosol located_inIEAUniProtKB:Q92905 and ensembl:ENSP000003505121600115GO_REF:0000107EnsemblGO_REF:0000107
Cops5Ratmitochondrion located_inISOCOPS5 (Sus scrofa)1624291 PMID:24091666RGDPMID:24091666
Cops5Ratnucleoplasm located_inIEAUniProtKB:Q92905 and ensembl:ENSP000003505121600115GO_REF:0000107EnsemblGO_REF:0000107
Cops5Ratnucleoplasm located_inISOCOPS5 (Homo sapiens)1624291 RGDGO_REF:0000052
Cops5Ratnucleoplasm located_inIEAUniProtKB:A0A024R7W9 and ensembl:ENSP000003505121600115GO_REF:0000107EnsemblGO_REF:0000107
Cops5Ratnucleus located_inISOCOPS5 (Homo sapiens)1624291 PMID:16300740 more ...RGDPMID:16300740 more ...
Cops5Ratnucleus located_inIEAUniProtKB:Q92905 and ensembl:ENSP000003505121600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function
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Original Reference(s)
Cops5RatdeNEDDylase activity enablesIBAFB:FBgn0027053 and PANTHER:PTN0000453691600115GO_REF:0000033GO_CentralGO_REF:0000033
Cops5Ratenzyme binding enablesISOCops5 (Mus musculus)1624291UniProtKB:O35215 and PMID:21817065RGDPMID:21817065
Cops5Ratenzyme binding enablesIEAUniProtKB:O35864 and ensembl:ENSMUSP000000270501600115GO_REF:0000107EnsemblGO_REF:0000107
Cops5Ratmacrophage migration inhibitory factor binding enablesISOCops5 (Mus musculus)1624291UniProtKB:P34884 and PMID:21817065RGDPMID:21817065
Cops5Ratmacrophage migration inhibitory factor binding enablesIEAUniProtKB:O35864 and ensembl:ENSMUSP000000270501600115GO_REF:0000107EnsemblGO_REF:0000107
Cops5Ratmetal-dependent deubiquitinase activity enablesISOCOPS5 (Homo sapiens)1624291 PMID:19246649RGDPMID:19246649
Cops5Ratmetal-dependent deubiquitinase activity enablesIEAUniProtKB:Q92905 and ensembl:ENSP000003505121600115GO_REF:0000107EnsemblGO_REF:0000107
Cops5Ratmetallopeptidase activity enablesISOCOPS5 (Homo sapiens)1624291 PMID:19214193RGDPMID:19214193
Cops5Ratmetallopeptidase activity enablesIEAUniProtKB-KW:KW-04821600115GO_REF:0000043UniProtGO_REF:0000043
Cops5Ratmetallopeptidase activity enablesIEAInterPro:IPR0005551600115GO_REF:0000002InterProGO_REF:0000002
Cops5Ratmetallopeptidase activity enablesIBAFB:FBgn0027053 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cops5Ratmetallopeptidase activity enablesIEAUniProtKB:Q92905 and ensembl:ENSP000003505121600115GO_REF:0000107EnsemblGO_REF:0000107
Cops5Ratpeptidase activity enablesIEAInterPro:IPR0005551600115GO_REF:0000002InterProGO_REF:0000002
Cops5Ratprotein binding enablesISOCOPS5 (Homo sapiens)1624291UniProtKB:O14879 more ...RGDPMID:12082530 more ...
Cops5Ratprotein binding enablesISOCops5 (Mus musculus)1624291PR:O88543 more ...RGDPMID:31146259 and PMID:9707402
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Imported Annotations - PID (archival)

Object Symbol
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Original Reference(s)
Cops5Rathypoxia inducible factor pathway   ISOCOPS5 (Homo sapiens)6484113 PIDPID:200202

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Down-regulation of the cyclin-dependent kinase inhibitor p57 is mediated by Jab1/Csn5 in hepatocarcinogenesis. Guo H, etal., Hepatology. 2016 Mar;63(3):898-913. doi: 10.1002/hep.28372. Epub 2016 Jan 14.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:9707402   PMID:12477932   PMID:15234121   PMID:15299027   PMID:16300740   PMID:16410250   PMID:17050680   PMID:18850735   PMID:19141280   PMID:19214193   PMID:19246649   PMID:20093369  
PMID:20978819   PMID:21102408   PMID:21817065   PMID:24091666  



Cops5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8513,975,198 - 13,993,391 (+)NCBIGRCr8
mRatBN7.259,192,233 - 9,210,498 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl59,192,100 - 9,210,731 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx511,344,273 - 11,362,693 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0512,971,568 - 12,989,792 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0512,678,930 - 12,697,346 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.058,876,090 - 8,894,345 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl58,876,044 - 8,894,339 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0513,684,111 - 13,702,378 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.458,709,214 - 8,727,277 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.158,709,213 - 8,727,277 (+)NCBI
Celera58,703,366 - 8,721,421 (+)NCBICelera
Cytogenetic Map5q11NCBI
COPS5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38867,043,079 - 67,062,133 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl867,043,079 - 67,083,783 (-)EnsemblGRCh38hg38GRCh38
GRCh37867,955,314 - 67,974,368 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36868,117,868 - 68,137,116 (-)NCBINCBI36Build 36hg18NCBI36
Build 34868,117,869 - 68,137,116NCBI
Celera863,948,870 - 63,967,877 (-)NCBICelera
Cytogenetic Map8q13.1NCBI
HuRef863,447,901 - 63,467,140 (-)NCBIHuRef
CHM1_1868,010,363 - 68,029,584 (-)NCBICHM1_1
T2T-CHM13v2.0867,469,560 - 67,488,599 (-)NCBIT2T-CHM13v2.0
Cops5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39110,094,825 - 10,108,384 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl110,094,826 - 10,108,393 (-)EnsemblGRCm39 Ensembl
GRCm38110,024,600 - 10,038,159 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl110,024,601 - 10,038,168 (-)EnsemblGRCm38mm10GRCm38
MGSCv37110,014,911 - 10,027,979 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36110,010,044 - 10,023,120 (-)NCBIMGSCv36mm8
Celera19,998,994 - 10,012,139 (-)NCBICelera
Cytogenetic Map1A2NCBI
cM Map12.29NCBI
Cops5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544412,217,337 - 12,234,193 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544412,217,337 - 12,233,570 (+)NCBIChiLan1.0ChiLan1.0
COPS5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2782,780,377 - 82,802,763 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1858,422,637 - 58,444,975 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0863,586,062 - 63,605,213 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1865,247,796 - 65,266,736 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl865,247,950 - 65,266,511 (-)Ensemblpanpan1.1panPan2
COPS5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12916,562,234 - 16,579,082 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2916,562,234 - 16,578,847 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2916,878,268 - 16,895,114 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02916,643,359 - 16,660,206 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2916,643,362 - 16,660,004 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12916,674,884 - 16,691,721 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02916,775,204 - 16,792,055 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02917,031,587 - 17,048,439 (-)NCBIUU_Cfam_GSD_1.0
Cops5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530367,734,939 - 67,749,504 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364967,035,924 - 7,050,786 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364967,035,973 - 7,050,538 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COPS5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl467,739,251 - 67,758,150 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1467,740,528 - 67,758,153 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2473,801,311 - 73,818,936 (+)NCBISscrofa10.2Sscrofa10.2susScr3
COPS5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1862,905,924 - 62,925,205 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl862,905,906 - 62,925,201 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603978,579,728 - 78,598,284 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cops5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474424,287,443 - 24,308,024 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474424,287,278 - 24,308,171 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Cops5
156 total Variants

Predicted Target Of
Summary Value
Count of predictions:104
Count of miRNA genes:87
Interacting mature miRNAs:95
Transcripts:ENSRNOT00000008877
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 11 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)5894822853948228Rat
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5213896532656739Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5511215947171491Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
631827Alc4Alcohol consumption QTL 43.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)5818750118616199Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5384401826141981Rat

1 to 10 of 11 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000008877   ⟹   ENSRNOP00000008877
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl59,192,100 - 9,210,731 (+)Ensembl
Rnor_6.0 Ensembl58,876,044 - 8,894,339 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099954   ⟹   ENSRNOP00000084575
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl59,192,100 - 9,210,731 (+)Ensembl
RefSeq Acc Id: NM_001025695   ⟹   NP_001020866
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8513,975,328 - 13,993,391 (+)NCBI
mRatBN7.259,192,431 - 9,210,498 (+)NCBI
Rnor_6.058,876,281 - 8,894,342 (+)NCBI
Rnor_5.0513,684,111 - 13,702,378 (+)NCBI
RGSC_v3.458,709,214 - 8,727,277 (+)RGD
Celera58,703,366 - 8,721,421 (+)RGD
Sequence:
RefSeq Acc Id: XM_006237758   ⟹   XP_006237820
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8513,975,198 - 13,993,391 (+)NCBI
mRatBN7.259,192,233 - 9,210,498 (+)NCBI
Rnor_6.058,876,090 - 8,894,345 (+)NCBI
Rnor_5.0513,684,111 - 13,702,378 (+)NCBI
Sequence:
Protein RefSeqs NP_001020866 (Get FASTA)   NCBI Sequence Viewer  
  XP_006237820 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98736 (Get FASTA)   NCBI Sequence Viewer  
  EDM11550 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000008877
  ENSRNOP00000008877.5
  ENSRNOP00000084575.1
RefSeq Acc Id: NP_001020866   ⟸   NM_001025695
- UniProtKB: Q4KM69 (UniProtKB/TrEMBL),   A0A8I5ZYE7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237820   ⟸   XM_006237758
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000008877   ⟸   ENSRNOT00000008877
Ensembl Acc Id: ENSRNOP00000084575   ⟸   ENSRNOT00000099954
MPN

Name Modeler Protein Id AA Range Protein Structure
AF-F7EUU4-F1-model_v2 AlphaFold F7EUU4 1-389 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693534
Promoter ID:EPDNEW_R4059
Type:initiation region
Name:Cops5_1
Description:COP9 signalosome subunit 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.058,876,051 - 8,876,111EPDNEW


1 to 25 of 25 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-42210 BioCyc
Ensembl Genes ENSRNOG00000006499 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008877 ENTREZGENE
  ENSRNOT00000008877.7 UniProtKB/TrEMBL
  ENSRNOT00000099954.1 UniProtKB/TrEMBL
Gene3D-CATH Cytidine Deaminase, domain 2 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7385252 IMAGE-MGC_LOAD
InterPro CSN5_C UniProtKB/TrEMBL
  JAMM_MPN+_peptidase_M67A UniProtKB/TrEMBL
  Mov34_MPN_PAD1 UniProtKB/TrEMBL
  MPN UniProtKB/TrEMBL
KEGG Report rno:312916 UniProtKB/TrEMBL
MGC_CLONE MGC:112728 IMAGE-MGC_LOAD
NCBI Gene 312916 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED UniProtKB/TrEMBL
Pfam CSN5_C UniProtKB/TrEMBL
  Mov34 UniProtKB/TrEMBL
PhenoGen Cops5 PhenoGen
PROSITE MPN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006499 RatGTEx
SMART JAB_MPN UniProtKB/TrEMBL
Superfamily-SCOP JAB1/MPN domain UniProtKB/TrEMBL
UniProt A0A8I5ZYE7 ENTREZGENE, UniProtKB/TrEMBL
  F7EUU4_RAT UniProtKB/TrEMBL
  Q4KM69 ENTREZGENE, UniProtKB/TrEMBL
1 to 25 of 25 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-20 Cops5  COP9 signalosome subunit 5  Cops5  COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Cops5  COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)  Cops5  COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Cops5  COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana)  Cops5_predicted  COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Cops5_predicted  COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana) (predicted)      Symbol and Name status set to approved 70820 APPROVED