Tfr2 (transferrin receptor 2) - Rat Genome Database

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Gene: Tfr2 (transferrin receptor 2) Rattus norvegicus
Analyze
Symbol: Tfr2
Name: transferrin receptor 2
RGD ID: 1310152
Description: Predicted to enable co-receptor binding activity and transferrin receptor activity. Involved in acute-phase response. Predicted to be located in cytoplasmic vesicle and plasma membrane. Predicted to be part of HFE-transferrin receptor complex. Predicted to be active in external side of plasma membrane. Used to study hemochromatosis type 3. Human ortholog(s) of this gene implicated in hemochromatosis and hemochromatosis type 3. Orthologous to human TFR2 (transferrin receptor 2); INTERACTS WITH 17beta-estradiol; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC288562; transferrin receptor protein 2; Trfr2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81224,744,450 - 24,761,413 (-)NCBIGRCr8
mRatBN7.21219,107,673 - 19,124,622 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1219,107,673 - 19,124,591 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1220,263,117 - 20,280,127 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01220,875,998 - 20,893,008 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01219,940,332 - 19,957,342 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,177,382 - 22,194,330 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,177,382 - 22,194,299 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,194,288 - 24,211,237 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41219,638,502 - 19,655,420 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11219,628,960 - 19,644,982 (+)NCBI
Celera1220,912,852 - 20,929,749 (-)NCBICelera
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tfr2Ratacute myeloid leukemia disease_progressionISOTFR2 (Homo sapiens)11062090 RGD 
Tfr2Ratbeta thalassemia  ISOTfr2 (Mus musculus)11062138mRNA:decreased expression:liver:RGD 
Tfr2Rathemochromatosis  ISOTFR2 (Homo sapiens)1599386hemochromatosis more ...RGD 
Tfr2Rathemochromatosis type 3  IAGP 150520058DNA:missense mutation:cds:Ala679Gly (rat)RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tfr2Ratgenetic disease  ISOTFR2 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
Tfr2Rathemochromatosis  ISOTFR2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10802645 more ...
Tfr2Rathemochromatosis  ISOTFR2 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary hemochromatosisClinVarPMID:10802645 more ...
Tfr2Rathemochromatosis  ISOTFR2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11313241 more ...
Tfr2Rathemochromatosis type 1  ISOTFR2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:12150153 more ...
Tfr2Rathemochromatosis type 3  ISOTFR2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10802645 more ...
Tfr2Rathemochromatosis type 5  ISOTFR2 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary hemochromatosis type 5ClinVarPMID:28492532
Tfr2Ratpleomorphic xanthoastrocytoma  ISOTFR2 (Homo sapiens)8554872ClinVar Annotator: match by term: Pleomorphic xanthoastrocytomaClinVarPMID:28299358
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tfr2Ratbeta thalassemia  ISOTFR2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16755567
Tfr2Rathemochromatosis  ISOTFR2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16935854 more ...
Tfr2Rathemochromatosis type 3  ISOTFR2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Object Symbol
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With
Reference
Notes
Source
Original Reference(s)
Tfr2Rathemochromatosis type 3  ISSTfr2 (Mus musculus)13592920OMIM:604250MouseDO 
Object Symbol
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Reference
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Original Reference(s)
Tfr2Rathemochromatosis type 3  ISOTFR2 (Homo sapiens)7240710 OMIM 

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tfr2Rat(1->4)-beta-D-glucan multiple interactionsISOTfr2 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of TFR2 mRNACTDPMID:36331819
Tfr2Rat1,1-dichloroethene increases expressionISOTfr2 (Mus musculus)6480464vinylidene chloride results in increased expression of TFR2 mRNACTDPMID:26682919
Tfr2Rat17beta-estradiol decreases expressionISOTfr2 (Mus musculus)6480464Estradiol results in decreased expression of TFR2 mRNACTDPMID:19484750
Tfr2Rat17beta-estradiol increases expressionISOTfr2 (Mus musculus)6480464Estradiol results in increased expression of TFR2 mRNACTDPMID:39298647
Tfr2Rat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of TFR2 proteinCTDPMID:32145629
Tfr2Rat2,2',5,5'-tetrachlorobiphenyl increases expressionEXP 64804642 more ...CTDPMID:23829299
Tfr2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOTfr2 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of TFR2 mRNACTDPMID:18163543 and PMID:28213091
Tfr2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of TFR2 mRNACTDPMID:32109520
Tfr2Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOTfr2 (Mus musculus)64804642 more ...CTDPMID:38648751
Tfr2Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of TFR2 mRNACTDPMID:21346803
Tfr2Rat2-butoxyethanol increases expressionISOTfr2 (Mus musculus)6480464n-butoxyethanol results in increased expression of TFR2 mRNACTDPMID:19812364
Tfr2Rat4,4'-diaminodiphenylmethane decreases expressionISOTfr2 (Mus musculus)64804644 and 4'-diaminodiphenylmethane results in decreased expression of TFR2 mRNACTDPMID:18648102
Tfr2Rat4,4'-sulfonyldiphenol decreases expressionISOTFR2 (Homo sapiens)6480464bisphenol S results in decreased expression of TFR2 mRNACTDPMID:27685785
Tfr2Rat4,4'-sulfonyldiphenol affects expressionISOTfr2 (Mus musculus)6480464bisphenol S affects the expression of TFR2 mRNACTDPMID:39298647
Tfr2Ratacetamide decreases expressionEXP 6480464acetamide results in decreased expression of TFR2 mRNACTDPMID:31881176
Tfr2Ratacrylamide decreases expressionEXP 6480464Acrylamide results in decreased expression of TFR2 mRNACTDPMID:28959563
Tfr2Ratacrylamide decreases expressionISOTFR2 (Homo sapiens)6480464Acrylamide results in decreased expression of TFR2 mRNACTDPMID:32763439
Tfr2Rataflatoxin B1 decreases expressionISOTFR2 (Homo sapiens)6480464Aflatoxin B1 results in decreased expression of TFR2 mRNACTDPMID:27153756
Tfr2Ratall-trans-retinoic acid multiple interactionsISOTfr2 (Mus musculus)6480464[mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of TFR2 mRNACTDPMID:36189433
Tfr2Ratarsane increases methylationISOTFR2 (Homo sapiens)6480464Arsenic results in increased methylation of TFR2 geneCTDPMID:28242323

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Biological Process
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tfr2Ratacute-phase response  IEP 11062091 RGD 
Tfr2Ratcellular response to iron ion involved_inISOTFR2 (Homo sapiens)1624291UniProtKB:P02787 more ...RGDPMID:18353247
Tfr2Ratendocytic iron import into cell involved_inISOTFR2 (Homo sapiens)1624291UniProtKB:P02787 more ...RGDPMID:18353247
Tfr2Ratendocytic iron import into cell involved_inIBAPANTHER:PTN002572073 and UniProtKB:Q9UP521600115GO_REF:0000033GO_CentralGO_REF:0000033
Tfr2Ratintracellular iron ion homeostasis involved_inISOTFR2 (Homo sapiens)1624291 PMID:18353247RGDPMID:18353247
Tfr2Ratmulticellular organismal-level iron ion homeostasis involved_inISOTFR2 (Homo sapiens)1624291 PMID:21173098RGDPMID:21173098
Tfr2Ratmulticellular organismal-level iron ion homeostasis acts_upstream_of_or_withinISOTfr2 (Mus musculus)1624291MGI:2384726 PMID:22960056RGDPMID:22960056
Tfr2Ratpositive regulation of endocytosis involved_inISOTFR2 (Homo sapiens)1624291UniProtKB:P61769 more ...RGDPMID:18353247
Tfr2Ratpositive regulation of peptide hormone secretion involved_inISOTFR2 (Homo sapiens)1624291 PMID:21173098RGDPMID:21173098
Tfr2Ratpositive regulation of protein maturation involved_inISOTFR2 (Homo sapiens)1624291UniProtKB:P61769 more ...RGDPMID:18353247
Tfr2Ratpositive regulation of transcription by RNA polymerase II involved_inISOTFR2 (Homo sapiens)1624291UniProtKB:P60033 and PMID:25635054RGDPMID:25635054
Tfr2Ratreceptor-mediated endocytosis involved_inISOTFR2 (Homo sapiens)1624291UniProtKB:Q07891 more ...RGDPMID:18353247
Tfr2Ratresponse to iron ion involved_inISOTFR2 (Homo sapiens)1624291 PMID:21173098RGDPMID:21173098
Tfr2Rattransferrin transport involved_inISOTFR2 (Homo sapiens)1624291UniProtKB:P02787 more ...RGDPMID:18353247
Tfr2Rattransferrin transport involved_inIEAInterPro:IPR0373241600115GO_REF:0000002InterProGO_REF:0000002
Tfr2Ratvesicle-mediated transport involved_inIEAGO:00049981600115GO_REF:0000108GOCGO_REF:0000108
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Cellular Component
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Molecular Function

  


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#
Reference Title
Reference Citation
1. A novel rat model of hereditary hemochromatosis due to a mutation in transferrin receptor 2. Bartnikas TB, etal., Comp Med. 2013 Apr;63(2):143-55.
2. The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22. Camaschella C, etal., Nat Genet. 2000 May;25(1):14-5.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Comparison of changes in gene expression of transferrin receptor-1 and other iron-regulatory proteins in rat liver and brain during acute-phase response. Malik IA, etal., Cell Tissue Res. 2011 May;344(2):299-312. doi: 10.1007/s00441-011-1152-3. Epub 2011 Mar 26.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Elevated levels of transferrin receptor 2 mRNA, not transferrin receptor 1 mRNA, are associated with increased survival in acute myeloid leukaemia. Nakamaki T, etal., Br J Haematol. 2004 Apr;125(1):42-9.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. mRNA expression of iron regulatory genes in beta-thalassemia intermedia and beta-thalassemia major mouse models. Weizer-Stern O, etal., Am J Hematol. 2006 Jul;81(7):479-83.
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PMID:12477932   PMID:12704209   PMID:16893896   PMID:16932966   PMID:18353247   PMID:19250966   PMID:21173098   PMID:22728873   PMID:22960056   PMID:25635054   PMID:31707638   PMID:32521439  



Tfr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81224,744,450 - 24,761,413 (-)NCBIGRCr8
mRatBN7.21219,107,673 - 19,124,622 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1219,107,673 - 19,124,591 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1220,263,117 - 20,280,127 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01220,875,998 - 20,893,008 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01219,940,332 - 19,957,342 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,177,382 - 22,194,330 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,177,382 - 22,194,299 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,194,288 - 24,211,237 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41219,638,502 - 19,655,420 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11219,628,960 - 19,644,982 (+)NCBI
Celera1220,912,852 - 20,929,749 (-)NCBICelera
Cytogenetic Map12q12NCBI
TFR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387100,620,420 - 100,641,552 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7100,620,416 - 100,642,779 (-)EnsemblGRCh38hg38GRCh38
GRCh377100,218,043 - 100,239,175 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367100,055,975 - 100,077,109 (-)NCBINCBI36Build 36hg18NCBI36
Build 34799,862,690 - 99,883,810NCBI
Celera794,947,821 - 94,968,950 (-)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef794,849,520 - 94,870,648 (-)NCBIHuRef
CHM1_17100,148,586 - 100,169,685 (-)NCBICHM1_1
T2T-CHM13v2.07101,860,501 - 101,881,634 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2799,577,671 - 99,598,799 (-)NCBI
Tfr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395137,568,127 - 137,586,344 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5137,568,102 - 137,585,743 (+)EnsemblGRCm39 Ensembl
GRCm385137,569,822 - 137,588,081 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5137,569,840 - 137,587,481 (+)EnsemblGRCm38mm10GRCm38
MGSCv375138,011,079 - 138,028,709 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365137,800,593 - 137,817,260 (+)NCBIMGSCv36mm8
Celera5134,553,519 - 134,571,033 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.57NCBI
Tfr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955573272,289 - 291,668 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955573272,315 - 289,227 (+)NCBIChiLan1.0ChiLan1.0
TFR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26118,531,714 - 118,554,217 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17166,796,330 - 166,818,842 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0792,647,431 - 92,669,889 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17106,048,497 - 106,060,481 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7106,048,935 - 106,069,238 (-)Ensemblpanpan1.1panPan2
TFR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.169,059,501 - 9,076,646 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl69,060,629 - 9,076,158 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha610,763,917 - 10,781,061 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.068,993,681 - 9,010,842 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl68,993,652 - 9,010,354 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.168,846,198 - 8,863,361 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.068,823,694 - 8,841,037 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.069,006,114 - 9,023,274 (+)NCBIUU_Cfam_GSD_1.0
Tfr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344133,353,500 - 133,368,393 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936543668,157 - 682,174 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936543667,570 - 681,872 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TFR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl38,539,320 - 8,578,763 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.138,539,316 - 8,553,993 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.237,934,261 - 7,948,960 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TFR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12812,570,604 - 12,592,269 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2812,571,841 - 12,592,266 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660703,712,690 - 3,733,677 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tfr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474016,452,504 - 16,466,781 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474016,451,520 - 16,469,393 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Tfr2
105 total Variants

Predicted Target Of
Summary Value
Count of predictions:62
Count of miRNA genes:55
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000001905
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
61443Btemp2Thermal response to stress QTL 23.30.000094body temperature trait (VT:0005535)core body temperature (CMO:0001036)121502518320794014Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat

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alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 45 113 91 90 59 25 59 6 214 93 93 45 60 31


1 to 19 of 19 rows
RefSeq Transcripts NM_001105916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001437217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001437218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001437219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001437220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001437221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001437222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC107410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC166451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 19 of 19 rows

Ensembl Acc Id: ENSRNOT00000001905   ⟹   ENSRNOP00000001905
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1219,107,673 - 19,124,591 (-)Ensembl
Rnor_6.0 Ensembl1222,177,382 - 22,194,299 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082895   ⟹   ENSRNOP00000072585
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1219,107,673 - 19,124,591 (-)Ensembl
Rnor_6.0 Ensembl1222,177,402 - 22,194,287 (-)Ensembl
RefSeq Acc Id: NM_001105916   ⟹   NP_001099386
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81224,744,450 - 24,761,368 (-)NCBI
mRatBN7.21219,107,673 - 19,124,591 (-)NCBI
Rnor_6.01222,177,382 - 22,194,299 (-)NCBI
Rnor_5.01224,194,288 - 24,211,237 (-)NCBI
RGSC_v3.41219,638,502 - 19,655,420 (+)RGD
Celera1220,912,852 - 20,929,749 (-)RGD
Sequence:
RefSeq Acc Id: XM_006249116   ⟹   XP_006249178
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81224,744,468 - 24,761,413 (-)NCBI
mRatBN7.21219,107,691 - 19,124,622 (-)NCBI
Rnor_6.01222,177,400 - 22,194,330 (-)NCBI
Rnor_5.01224,194,288 - 24,211,237 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006249117   ⟹   XP_006249179
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81224,744,468 - 24,761,375 (-)NCBI
mRatBN7.21219,107,691 - 19,124,589 (-)NCBI
Rnor_6.01222,177,400 - 22,194,300 (-)NCBI
Rnor_5.01224,194,288 - 24,211,237 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006249118   ⟹   XP_006249180
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81224,744,468 - 24,761,359 (-)NCBI
mRatBN7.21219,107,691 - 19,124,616 (-)NCBI
Rnor_6.01222,177,400 - 22,194,324 (-)NCBI
Rnor_5.01224,194,288 - 24,211,237 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008769125   ⟹   XP_008767347
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81224,744,468 - 24,761,379 (-)NCBI
mRatBN7.21219,107,691 - 19,124,605 (-)NCBI
Rnor_6.01222,177,400 - 22,194,298 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008769127   ⟹   XP_008767349
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81224,744,468 - 24,761,413 (-)NCBI
mRatBN7.21219,107,691 - 19,124,622 (-)NCBI
Rnor_6.01222,177,400 - 22,194,330 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001099386   ⟸   NM_001105916
- UniProtKB: B2GUY2 (UniProtKB/Swiss-Prot),   A0A8L2UQK5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249178   ⟸   XM_006249116
- Peptide Label: isoform X1
- UniProtKB: A0A8L2UQK5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249180   ⟸   XM_006249118
- Peptide Label: isoform X2
- UniProtKB: B2GUY2 (UniProtKB/Swiss-Prot),   A0A8L2UQK5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249179   ⟸   XM_006249117
- Peptide Label: isoform X2
- UniProtKB: B2GUY2 (UniProtKB/Swiss-Prot),   A0A8L2UQK5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767349   ⟸   XM_008769127
- Peptide Label: isoform X3
- UniProtKB: A0A8L2UQK5 (UniProtKB/TrEMBL)
- Sequence:
PA   Peptidase M28

Name Modeler Protein Id AA Range Protein Structure
AF-B2GUY2-F1-model_v2 AlphaFold B2GUY2 1-798 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698522
Promoter ID:EPDNEW_R9041
Type:multiple initiation site
Name:Tfr2_1
Description:transferrin receptor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01222,194,293 - 22,194,353EPDNEW


1 to 30 of 30 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-19707 BioCyc
Ensembl Genes ENSRNOG00000001407 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001905 ENTREZGENE
  ENSRNOT00000001905.7 UniProtKB/Swiss-Prot
  ENSRNOT00000124044 ENTREZGENE
  ENSRNOT00000161275 ENTREZGENE
Gene3D-CATH 1.20.930.40 UniProtKB/Swiss-Prot
  3.50.30.30 UniProtKB/Swiss-Prot
  Zn peptidases UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:8371649 IMAGE-MGC_LOAD
InterPro PA_dom_sf UniProtKB/Swiss-Prot
  PA_domain UniProtKB/Swiss-Prot
  Peptidase_M28 UniProtKB/Swiss-Prot
  Peptidase_M28B UniProtKB/Swiss-Prot
  TFR-like_dimer_dom_sf UniProtKB/Swiss-Prot
  TfR1/2_PA UniProtKB/Swiss-Prot
KEGG Report rno:288562 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187679 IMAGE-MGC_LOAD
NCBI Gene 288562 ENTREZGENE
PANTHER PTHR10404 UniProtKB/Swiss-Prot
  TRANSFERRIN RECEPTOR PROTEIN 2 UniProtKB/Swiss-Prot
Pfam Peptidase_M28 UniProtKB/Swiss-Prot
  PF02225 UniProtKB/Swiss-Prot
PhenoGen Tfr2 PhenoGen
RatGTEx ENSRNOG00000001407 RatGTEx
Superfamily-SCOP PA domain UniProtKB/Swiss-Prot
  SSF47672 UniProtKB/Swiss-Prot
  Zn-dependent exopeptidases UniProtKB/Swiss-Prot
UniProt A0A8L2UQK5 ENTREZGENE, UniProtKB/TrEMBL
  B2GUY2 ENTREZGENE, UniProtKB/Swiss-Prot
1 to 30 of 30 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Tfr2  transferrin receptor 2  Trfr2  transferrin receptor 2   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Trfr2  transferrin receptor 2   Trfr2_predicted  transferrin receptor 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Trfr2_predicted  transferrin receptor 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED