Gsta4 (glutathione S-transferase alpha 4) - Rat Genome Database

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Gene: Gsta4 (glutathione S-transferase alpha 4) Rattus norvegicus
Analyze
Symbol: Gsta4
Name: glutathione S-transferase alpha 4
RGD ID: 1309970
Description: Enables toxic substance binding activity. Involved in several processes, including cellular response to lithium ion; response to herbicide; and response to zinc ion. Predicted to be located in cytosol and mitochondrion. Orthologous to human GSTA4 (glutathione S-transferase alpha 4); PARTICIPATES IN glutathione conjugation pathway; glutathione metabolic pathway; phase I biotransformation pathway via cytochrome P450; INTERACTS WITH (+)-schisandrin B; (E)-4-hydroxynon-2-enal; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glutathione S-transferase A4; glutathione S-transferase alpha-4; glutathione S-transferase Yk; glutathione S-transferase, alpha 4; glutathione transferase; GST 8-8; GST A4-4; GST K; GST Yk; LOC300850
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gsta4-ps2  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8887,947,247 - 87,964,490 (+)NCBIGRCr8
mRatBN7.2879,066,967 - 79,084,193 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl879,066,934 - 79,084,182 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx884,554,453 - 84,571,445 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0882,831,109 - 82,848,101 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0880,653,832 - 80,670,824 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0885,497,557 - 85,514,732 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl885,497,557 - 85,518,879 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0885,062,036 - 85,078,502 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4883,165,139 - 83,183,055NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera878,811,797 - 78,829,038 (+)NCBICelera
Cytogenetic Map8q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Gsta4RatBurns  ISORGD:13206015687774mRNA:altered expression:fat, muscle, skin (human)RGD 
Gsta4RatBurns  ISORGD:13206025687774mRNA:decreased expression:gastrocnemius muscle (mouse)RGD 
Gsta4Ratcolitis  ISORGD:13206025687963protein:increased expression:colon, epithelial cell (mouse)RGD 
Gsta4RatExperimental Diabetes Mellitus  IEP 5687773protein:increased expression:pancreas, kidney, liver (rat)RGD 
Gsta4RatExperimental Liver Cirrhosis treatmentIDA 9685568 RGD 
Gsta4RatInsulin Resistance  ISORGD:13206015687771mRNA:decreased expression:omental fat pad, subcutaneous adipose tissue (human)RGD 
Gsta4RatLiver Injury  IEP 10401911mRNA, protein:increased expression:liverRGD 
Gsta4Ratobesity  ISORGD:13206025687771mRNA:decreased expression:gonadal fat pad (mouse)RGD 
Gsta4RatParkinson's disease  ISORGD:13206025687772mRNA:increased expression:striatum (mouse)RGD 
Gsta4RatPseudomonas Infections susceptibilityISORGD:13206025687774 RGD 
Gsta4RatSpinal Cord Injuries  IEP 5687769mRNA:increased expression:lumbar segment of spinal cord (rat)RGD 
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Original Reference(s)
Gsta4Ratarteriosclerosis  ISORGD:132060111554173CTD Direct Evidence: marker/mechanism|therapeuticCTDPMID:15064094|PMID:20177342
Gsta4RatChemical and Drug Induced Liver Injury  ISORGD:132060111554173CTD Direct Evidence: marker/mechanismCTDPMID:25231249
Gsta4RatParkinson's disease  ISORGD:132060111554173CTD Direct Evidence: marker/mechanismCTDPMID:16510128
Gsta4Ratpre-malignant neoplasm  ISORGD:132060111554173CTD Direct Evidence: marker/mechanismCTDPMID:20180811

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Gsta4Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of GSTA4 mRNA]CTDPMID:31150632
Gsta4Rat(-)-epigallocatechin 3-gallate multiple interactionsISORGD:13206016480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GSTA4 mRNACTDPMID:22079256
Gsta4Rat(1->4)-beta-D-glucan multiple interactionsISORGD:13206026480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of GSTA4 mRNACTDPMID:36331819
Gsta4Rat(E)-4-hydroxynon-2-enal affects bindingEXP 1641942(E)-4-hydroxynon-2-enal binds to Gsta4 proteinRGD 
Gsta4Rat(S)-nicotine decreases expressionEXP 6480464Nicotine results in decreased expression of GSTA4 mRNACTDPMID:9774145
Gsta4Rat(S)-nicotine multiple interactionsISORGD:13206026480464[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GSTA4 mRNA; Nicotine inhibits the reaction more ...CTDPMID:20230807|PMID:23933227
Gsta4Rat(S)-nicotine increases expressionEXP 6480464Nicotine results in increased expression of GSTA4 mRNACTDPMID:9774145
Gsta4Rat(S)-nicotine increases activityEXP 6480464Nicotine results in increased activity of GSTA4 proteinCTDPMID:9774145
Gsta4Rat1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactionsISORGD:13206026480464[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...CTDPMID:25510870
Gsta4Rat1,2-dimethylhydrazine increases expressionISORGD:132060264804641,2-Dimethylhydrazine results in increased expression of GSTA4 mRNACTDPMID:22206623
Gsta4Rat1-chloro-2,4-dinitrobenzene affects bindingEXP 16419421-chloro-2 4-dinitrobenzene binds to Gsta4 proteinRGD 
Gsta4Rat1-chloro-2,4-dinitrobenzene affects expressionISORGD:13206026480464Dinitrochlorobenzene affects the expression of GSTA4 mRNACTDPMID:28219650
Gsta4Rat1-chloro-2,4-dinitrobenzene affects metabolic processingEXP 6480464GSTA4 protein affects the metabolism of DinitrochlorobenzeneCTDPMID:2619714
Gsta4Rat1-chloro-2,4-dinitrobenzene multiple interactionsISORGD:13206016480464[GSTA1 protein binds to GSTA4 protein] which affects the metabolism of Dinitrochlorobenzene; [GSTA4 protein binds more ...CTDPMID:11851347
Gsta4Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactionsISORGD:13206026480464[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GSTA4 mRNA; Nicotine inhibits the reaction more ...CTDPMID:20230807|PMID:23933227
Gsta4Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases expressionISORGD:132060264804641-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GSTA4 mRNA; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GSTA4 more ...CTDPMID:20230807|PMID:23933227
Gsta4Rat13-oxo-9,11-octadecadienoic acid affects metabolic processingISORGD:13206016480464GSTA4 protein affects the metabolism of 13-oxo-9,11-octadecadienoic acidCTDPMID:12031293
Gsta4Rat17alpha-ethynylestradiol affects expressionEXP 6480464Ethinyl Estradiol affects the expression of GSTA4 mRNACTDPMID:15212814
Gsta4Rat17alpha-ethynylestradiol decreases expressionISORGD:13206026480464Ethinyl Estradiol results in decreased expression of GSTA4 mRNACTDPMID:14976129
Gsta4Rat17alpha-ethynylestradiol increases expressionISORGD:13206026480464Ethinyl Estradiol results in increased expression of GSTA4 mRNACTDPMID:17942748

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Biological Process
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Original Reference(s)
Gsta4Ratcellular response to lithium ion  IEP 2293846 RGD 
Gsta4Ratglutathione metabolic process involved_inISORGD:13206011624291 PMID:10329152RGDPMID:10329152
Gsta4Ratglutathione metabolic process involved_inIBAFB:FBgn0010226|MGI:95864|MGI:95865|PANTHER:PTN000170884|RGD:2755|RGD:2756|UniProtKB:O15217|UniProtKB:P08263|UniProtKB:P09211|UniProtKB:P09488|UniProtKB:P21266|UniProtKB:P28161|UniProtKB:P46439|UniProtKB:Q03013|UniProtKB:Q8ILQ7|WB:WBGene00001752|WB:WBGene000017581600115GO_REF:0000033GO_CentralGO_REF:0000033
Gsta4Ratresponse to caloric restriction acts_upstream_of_or_withinISORGD:13206021624291 PMID:36421460RGDPMID:36421460
Gsta4Ratresponse to herbicide  IEP 5130934paraquatRGD 
Gsta4Ratresponse to nicotine  IEP 5687770 RGD 
Gsta4Ratresponse to zinc ion  IEP 5130934 RGD 
Gsta4Ratxenobiotic metabolic process involved_inISORGD:13206011624291 PMID:10329152RGDPMID:10329152
Gsta4Ratxenobiotic metabolic process involved_inIBAPANTHER:PTN002480403|RGD:1593189|RGD:2753|RGD:2754|UniProtKB:O152171600115GO_REF:0000033GO_CentralGO_REF:0000033
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Cellular Component

  
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Original Reference(s)
Gsta4Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Gsta4Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Gsta4Ratcytosol located_inISORGD:13206011624291 PMID:15100242RGDPMID:15100242
Gsta4Ratmitochondrion located_inISORGD:13206021624291 PMID:12020353RGDPMID:12020353

Molecular Function
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Gsta4Ratglutathione transferase activity enablesISORGD:13206011624291 PMID:10329152, PMID:11851347RGDPMID:10329152|PMID:11851347
Gsta4Ratglutathione transferase activity enablesIEAEC:2.5.1.181600115GO_REF:0000003UniProtGO_REF:0000003
Gsta4Ratglutathione transferase activity enablesIBAFB:FBgn0010226|MGI:1095417|MGI:1309466|MGI:95856|MGI:95861|MGI:95862|MGI:95863|MGI:95864|MGI:95865|PANTHER:PTN000170884|RGD:1593189|RGD:2753|RGD:2754|RGD:2755|RGD:2756|RGD:61964|UniProtKB:C8V321|UniProtKB:O15217|UniProtKB:P08263|UniProtKB:P09211|UniProtKB:P09488|UniProtKB:P21266|UniProtKB:P28161|UniProtKB:P46439|UniProtKB:Q03013|UniProtKB:Q8ILQ7|WB:WBGene00001749|WB:WBGene00001752|WB:WBGene00001758|ZFIN:ZDB-GENE-020806-4|ZFIN:ZDB-GENE-030911-2|ZFIN:ZDB-GENE-050309-24|ZFIN:ZDB-GENE-050601-1|dictyBase:DDB_G02726321600115GO_REF:0000033GO_CentralGO_REF:0000033
Gsta4Ratglutathione transferase activity enablesIEAInterPro:IPR0030801600115GO_REF:0000002InterProGO_REF:0000002
Gsta4Ratidentical protein binding enablesISORGD:13206011624291UniProtKB:O15217 PMID:16189514, PMID:25416956, PMID:32296183RGDPMID:16189514|PMID:25416956|PMID:32296183
Gsta4Ratprotein binding enablesISORGD:13206011624291UniProtKB:O15116|UniProtKB:O95995|UniProtKB:P09210|UniProtKB:P19712-PRO_0000038050|UniProtKB:Q96HA8|UniProtKB:Q96LR7 PMID:24965446, PMID:25416956, PMID:25910212, PMID:28514442, PMID:31515488, PMID:32296183, PMID:33961781RGDPMID:24965446|PMID:25416956|PMID:25910212|PMID:28514442|PMID:31515488|PMID:32296183|PMID:33961781
Gsta4Ratprotein homodimerization activity enablesISORGD:13206011624291UniProtKB:O15217 PMID:10329152RGDPMID:10329152
Gsta4Rattoxic substance binding  IPICHEBI:589681641942 RGD 
Gsta4Rattransferase activity enablesIEAUniProtKB-KW:KW-08081600115GO_REF:0000043UniProtGO_REF:0000043
1 to 9 of 9 rows

RGD Manual Annotations


  
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Gsta4Ratglutathione conjugation pathway  ISORGD:13206011358120 RGD 
Gsta4Ratglutathione conjugation pathway  IDA 1641942 RGD 

Imported Annotations - KEGG (archival)

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Gsta4Ratglutathione metabolic pathway  IEA 6907045 KEGGrno:00480
Gsta4Ratphase I biotransformation pathway via cytochrome P450  IEA 6907045 KEGGrno:00980
Gsta4Ratphase I biotransformation pathway via cytochrome P450  IEA 6907045 KEGGrno:00982

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Reference Title
Reference Citation
1. Biochemical and molecular mechanisms of N-acetyl cysteine and silymarin-mediated protection against maneb- and paraquat-induced hepatotoxicity in rats. Ahmad I, etal., Chem Biol Interact. 2013 Jan 25;201(1-3):9-18. doi: 10.1016/j.cbi.2012.10.027. Epub 2012 Nov 16.
2. Down-regulation of glutatione S-transferase alpha 4 (hGSTA4) in the muscle of thermally injured patients is indicative of susceptibility to bacterial infection. Apidianakis Y, etal., FASEB J. 2012 Feb;26(2):730-7. Epub 2011 Oct 28.
3. Preferential effects of nicotine and 4-(N-methyl-N-nitrosamine)-1-(3-pyridyl)-1-butanone on mitochondrial glutathione S-transferase A4-4 induction and increased oxidative stress in the rat brain. Bhagwat SV, etal., Biochem Pharmacol. 1998 Oct 1;56(7):831-9.
4. Downregulation of adipose glutathione S-transferase A4 leads to increased protein carbonylation, oxidative stress, and mitochondrial dysfunction. Curtis JM, etal., Diabetes. 2010 May;59(5):1132-42. Epub 2010 Feb 11.
5. Selective expression of detoxifying glutathione transferases in mouse colon: effect of experimental colitis and the presence of bacteria. Edalat M, etal., Histochem Cell Biol. 2004 Aug;122(2):151-9.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Effect of zinc and paraquat co-exposure on neurodegeneration: Modulation of oxidative stress and expression of metallothioneins, toxicant responsive and transporter genes in rats. Kumar A, etal., Free Radic Res. 2010 Aug;44(8):950-65.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. Elevated mitochondrial cytochrome P450 2E1 and glutathione S-transferase A4-4 in streptozotocin-induced diabetic rats: tissue-specific variations and roles in oxidative stress. Raza H, etal., Diabetes. 2004 Jan;53(1):185-94.
12. Characterization of 4-hydroxy-2-nonenal metabolism in stellate cell lines derived from normal and cirrhotic rat liver. Reichard JF, etal., Biochim Biophys Acta. 2000 Sep 27;1487(2-3):222-32.
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. The effect of mood stabilizer lithium on expression and activity of glutathione s-transferase isoenzymes. Shao L, etal., Neuroscience. 2008 Jan 24;151(2):518-24. Epub 2007 Nov 13.
16. Melatonin or silymarin reduces maneb- and paraquat-induced Parkinson's disease phenotype in the mouse. Singhal NK, etal., J Pineal Res. 2011 Mar;50(2):97-109. doi: 10.1111/j.1600-079X.2010.00819.x. Epub 2010 Oct 22.
17. Glutathione S-transferase: genetics and role in toxicology. Strange RC, etal., Toxicol Lett 2000 Mar 15;112-113:357-63.
18. Naturally Occurring Genetic Variability in Expression of Gsta4 is Associated with Differential Survival of Axotomized Rat Motoneurons. Strom M, etal., Neuromolecular Med. 2011 Dec 8.
19. Protective effect of Phellinus linteus polysaccharide extracts against thioacetamide-induced liver fibrosis in rats: a proteomics analysis. Wang H, etal., Chin Med. 2012 Oct 18;7(1):23. doi: 10.1186/1749-8546-7-23.
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PMID:1599415   PMID:2775231   PMID:10329152   PMID:11851347   PMID:12477932   PMID:16189514   PMID:16940154   PMID:24771067   PMID:25416956   PMID:25931508   PMID:32792491  



Gsta4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8887,947,247 - 87,964,490 (+)NCBIGRCr8
mRatBN7.2879,066,967 - 79,084,193 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl879,066,934 - 79,084,182 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx884,554,453 - 84,571,445 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0882,831,109 - 82,848,101 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0880,653,832 - 80,670,824 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0885,497,557 - 85,514,732 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl885,497,557 - 85,518,879 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0885,062,036 - 85,078,502 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4883,165,139 - 83,183,055NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera878,811,797 - 78,829,038 (+)NCBICelera
Cytogenetic Map8q31NCBI
GSTA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38652,977,953 - 52,995,284 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl652,977,948 - 52,995,304 (-)EnsemblGRCh38hg38GRCh38
GRCh37652,842,751 - 52,860,082 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36652,950,710 - 52,968,099 (-)NCBINCBI36Build 36hg18NCBI36
Build 34652,950,709 - 52,968,099NCBI
Celera654,504,520 - 54,521,952 (-)NCBICelera
Cytogenetic Map6p12.2NCBI
HuRef652,674,221 - 52,691,656 (-)NCBIHuRef
CHM1_1652,844,511 - 52,861,941 (-)NCBICHM1_1
T2T-CHM13v2.0652,817,518 - 52,834,853 (-)NCBIT2T-CHM13v2.0
Gsta4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39978,099,248 - 78,116,631 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl978,090,056 - 78,116,631 (+)EnsemblGRCm39 Ensembl
GRCm38978,191,966 - 78,209,349 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl978,182,774 - 78,209,349 (+)EnsemblGRCm38mm10GRCm38
MGSCv37978,039,773 - 78,057,156 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36977,977,701 - 77,995,033 (+)NCBIMGSCv36mm8
Celera975,369,930 - 75,387,302 (+)NCBICelera
Cytogenetic Map9E1NCBI
cM Map943.65NCBI
GSTA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2567,449,101 - 67,466,562 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1663,325,479 - 63,342,938 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0652,532,942 - 52,550,404 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1654,171,609 - 54,189,032 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl654,171,318 - 54,188,976 (-)Ensemblpanpan1.1panPan2
GSTA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11220,426,724 - 20,443,200 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1220,426,726 - 20,443,200 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1220,321,558 - 20,337,691 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01220,924,034 - 20,940,269 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1220,923,735 - 20,940,277 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11220,429,613 - 20,445,821 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01220,534,140 - 20,550,406 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01220,672,284 - 20,688,436 (-)NCBIUU_Cfam_GSD_1.0
LOC101958062
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494656,071,901 - 56,087,021 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364767,873,194 - 7,889,048 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364767,873,218 - 7,888,301 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GSTA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl746,635,902 - 46,656,450 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1746,635,903 - 46,656,491 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27134,379,987 - 134,400,475 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GSTA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11719,575,835 - 19,591,713 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1719,575,876 - 19,591,919 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604452,829,812 - 52,845,691 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gsta4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624850201,592 - 216,680 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624850201,119 - 217,302 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Gsta4
186 total Variants

Predicted Target Of
Summary Value
Count of predictions:11
Count of miRNA genes:11
Interacting mature miRNAs:11
Transcripts:ENSRNOT00000012348
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 57 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat

1 to 10 of 57 rows
RH131281  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2687,541,165 - 87,541,377 (+)MAPPERmRatBN7.2
mRatBN7.24120,320,186 - 120,320,396 (+)MAPPERmRatBN7.2
Rnor_6.04119,765,305 - 119,765,514NCBIRnor6.0
Rnor_6.0885,518,643 - 85,518,854NCBIRnor6.0
Cytogenetic Map8q31UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000012348   ⟹   ENSRNOP00000012346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl879,072,633 - 79,084,182 (+)Ensembl
Rnor_6.0 Ensembl885,503,224 - 85,514,670 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090146   ⟹   ENSRNOP00000075572
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl879,066,934 - 79,084,180 (+)Ensembl
Rnor_6.0 Ensembl885,497,557 - 85,518,879 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115538   ⟹   ENSRNOP00000086066
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl879,071,470 - 79,084,182 (+)Ensembl
RefSeq Acc Id: NM_001106840   ⟹   NP_001100310
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8887,947,265 - 87,964,490 (+)NCBI
mRatBN7.2879,066,967 - 79,084,193 (+)NCBI
Rnor_6.0885,497,557 - 85,514,732 (+)NCBI
Rnor_5.0885,062,036 - 85,078,502 (+)NCBI
RGSC_v3.4883,165,139 - 83,183,055 (+)RGD
Celera878,811,797 - 78,829,038 (+)RGD
Sequence:
RefSeq Acc Id: XM_063265184   ⟹   XP_063121254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8887,947,247 - 87,964,489 (+)NCBI
RefSeq Acc Id: XM_063265185   ⟹   XP_063121255
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8887,959,106 - 87,964,489 (+)NCBI
1 to 9 of 9 rows
Protein RefSeqs NP_001100310 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121254 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121255 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI57820 (Get FASTA)   NCBI Sequence Viewer  
  ACI32116 (Get FASTA)   NCBI Sequence Viewer  
  EDL77745 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075572
  ENSRNOP00000075572.1
GenBank Protein P14942 (Get FASTA)   NCBI Sequence Viewer  
1 to 9 of 9 rows
RefSeq Acc Id: NP_001100310   ⟸   NM_001106840
- UniProtKB: P14942 (UniProtKB/Swiss-Prot),   A9UMW1 (UniProtKB/TrEMBL),   B6DYP9 (UniProtKB/TrEMBL),   A6HBU1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075572   ⟸   ENSRNOT00000090146
Ensembl Acc Id: ENSRNOP00000012346   ⟸   ENSRNOT00000012348
Ensembl Acc Id: ENSRNOP00000086066   ⟸   ENSRNOT00000115538
RefSeq Acc Id: XP_063121254   ⟸   XM_063265184
- Peptide Label: isoform X1
- UniProtKB: P14942 (UniProtKB/Swiss-Prot),   A9UMW1 (UniProtKB/TrEMBL),   B6DYP9 (UniProtKB/TrEMBL),   A6HBU1 (UniProtKB/TrEMBL)
GST C-terminal   GST N-terminal

Name Modeler Protein Id AA Range Protein Structure
AF-P14942-F1-model_v2 AlphaFold P14942 1-222 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13696144
Promoter ID:EPDNEW_R6667
Type:initiation region
Name:Gsta4_1
Description:glutathione S-transferase alpha 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0885,497,534 - 85,497,594EPDNEW


1 to 35 of 35 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-29769 BioCyc
Ensembl Genes ENSRNOG00000030449 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000090146 ENTREZGENE
  ENSRNOT00000090146.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1050.10 UniProtKB/Swiss-Prot
  Glutaredoxin UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5621777 IMAGE-MGC_LOAD
InterPro Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot
  Glutathione_S-Trfase UniProtKB/Swiss-Prot
  Glutathione_S-Trfase_N UniProtKB/Swiss-Prot
  GST_alpha UniProtKB/Swiss-Prot
  GST_C UniProtKB/Swiss-Prot
  GST_superfamily UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:300850 UniProtKB/Swiss-Prot
MGC_CLONE MGC:188402 IMAGE-MGC_LOAD
NCBI Gene 300850 ENTREZGENE
PANTHER GLUTATHIONE S-TRANSFERASE UniProtKB/Swiss-Prot
  GLUTATHIONE S-TRANSFERASE A4 UniProtKB/Swiss-Prot
Pfam GST_C UniProtKB/Swiss-Prot
  GST_N UniProtKB/Swiss-Prot
PhenoGen Gsta4 PhenoGen
PRINTS GSTRNSFRASEA UniProtKB/Swiss-Prot
PROSITE GST_CTER UniProtKB/Swiss-Prot
  GST_NTER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000030449 RatGTEx
Superfamily-SCOP SSF47616 UniProtKB/Swiss-Prot
  SSF52833 UniProtKB/Swiss-Prot
UniProt A0A8I6A0I6_RAT UniProtKB/TrEMBL
  A0A8L2Q6M0_RAT UniProtKB/TrEMBL
  A6HBU1 ENTREZGENE, UniProtKB/TrEMBL
  A9UMW1 ENTREZGENE, UniProtKB/TrEMBL
  B6DYP9 ENTREZGENE, UniProtKB/TrEMBL
  GSTA4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 35 of 35 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-02-04 Gsta4  glutathione S-transferase alpha 4  Gsta4  glutathione S-transferase A4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-03 Gsta4  glutathione S-transferase A4  Gsta4  glutathione S-transferase, alpha 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Gsta4  glutathione S-transferase, alpha 4  Gsta4_predicted  glutathione S-transferase, alpha 4 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Gsta4_predicted  glutathione S-transferase, alpha 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED