Slc7a11 (solute carrier family 7 member 11) - Rat Genome Database

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Gene: Slc7a11 (solute carrier family 7 member 11) Rattus norvegicus
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Symbol: Slc7a11
Name: solute carrier family 7 member 11
RGD ID: 1309275
Description: Predicted to enable L-kynurenine transmembrane transporter activity and cystine:glutamate antiporter activity. Involved in lens fiber cell differentiation; response to nicotine; and response to oxidative stress. Predicted to be located in several cellular components, including astrocyte projection; brush border membrane; and cell surface. Orthologous to human SLC7A11 (solute carrier family 7 member 11); INTERACTS WITH (+)-schisandrin B; (R)-lipoic acid; (S)-AMPA.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cystine/glutamate transporter; LOC310392; solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11; solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Slc7a11Tn(sb-T2/Bart3)2.266Mcwi
Genetic Models: F344-Slc7a11Tn(sb-T2/Bart3)2.266Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82136,532,912 - 136,668,560 (-)NCBIGRCr8
mRatBN7.22134,382,002 - 134,517,622 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2133,963,107 - 134,517,536 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2141,015,140 - 141,089,464 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02139,127,676 - 139,201,998 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02133,756,818 - 133,831,146 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02139,453,774 - 139,528,479 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2139,453,774 - 139,528,162 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02158,930,294 - 159,004,937 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42139,241,142 - 139,317,101 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12139,198,359 - 139,266,947 (-)NCBI
Celera2128,949,395 - 129,023,474 (-)NCBICelera
Cytogenetic Map2q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
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Original Reference(s)
Slc7a11Rattongue squamous cell carcinoma severityISORGD:1319531151361157 RGD 
Object Symbol
Species
Term
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Evidence
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Reference
Notes
Source
Original Reference(s)
Slc7a11Ratcontact dermatitis  ISORGD:131953111554173CTD Direct Evidence: marker/mechanismCTDPMID:25724174
Slc7a11RatNeoplasm Metastasis  ISORGD:131953111554173CTD Direct Evidence: marker/mechanismCTDPMID:19015640
Object Symbol
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Original Reference(s)
Slc7a11RatHermansky-Pudlak syndrome  ISSRGD:131953213592920 MouseDO 
Slc7a11Ratplatelet storage pool deficiency  ISSRGD:131953213592920OMIM:185050MouseDO 

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Original Reference(s)
Slc7a11Rat(+)-dexrazoxane multiple interactionsISORGD:13195326480464Dexrazoxane inhibits the reaction [Cyclophosphamide results in decreased expression of SLC7A11 protein]CTDPMID:37690746
Slc7a11Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of SLC7A11 mRNA]CTDPMID:31150632
Slc7a11Rat(-)-alpha-phellandrene decreases expressionISORGD:13195316480464alpha phellandrene results in decreased expression of SLC7A11 mRNACTDPMID:25075043
Slc7a11Rat(-)-demecolcine increases expressionISORGD:13195316480464Demecolcine results in increased expression of SLC7A11 mRNACTDPMID:23649840
Slc7a11Rat(1->4)-beta-D-glucan multiple interactionsISORGD:13195326480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of SLC7A11 mRNACTDPMID:36331819
Slc7a11Rat(E)-thiamethoxam increases expressionISORGD:13195326480464Thiamethoxam results in increased expression of SLC7A11 mRNACTDPMID:33533595
Slc7a11Rat(R)-lipoic acid multiple interactionsEXP 6480464Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of SLC7A11 protein]; Thioctic more ...CTDPMID:32061141
Slc7a11Rat(R,R,R)-alpha-tocopherol multiple interactionsISORGD:13195316480464[alpha-Tocopherol co-treated with Paraquat] results in increased expression of SLC7A11 mRNA; [alpha-Tocopherol co-treated with Paraquat] more ...CTDPMID:24530478
Slc7a11Rat(S)-AMPA multiple interactionsEXP 6480464alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Propofol results in decreased expression of SLC7A11 protein]CTDPMID:28663055
Slc7a11Rat(S)-ropivacaine multiple interactionsISORGD:13195316480464[Ropivacaine results in increased susceptibility to Cisplatin] which results in decreased expression of SLC7A11 protein; more ...CTDPMID:39053794
Slc7a11Rat(S)-ropivacaine decreases expressionISORGD:13195316480464Ropivacaine results in decreased expression of SLC7A11 proteinCTDPMID:36124980
Slc7a11Rat1,3-benzothiazole-2-thiol increases expressionISORGD:13195316480464captax results in increased expression of SLC7A11 mRNACTDPMID:24211530
Slc7a11Rat1,3-dichloropropan-2-ol decreases expressionISORGD:131953264804641,3-dichloro-2-propanol results in decreased expression of SLC7A11 proteinCTDPMID:35870111
Slc7a11Rat1,3-dichloropropan-2-ol decreases expressionISORGD:131953164804641,3-dichloro-2-propanol results in decreased expression of SLC7A11 proteinCTDPMID:35870111
Slc7a11Rat1,3-dichloropropan-2-ol multiple interactionsISORGD:13195316480464[Thiazoles binds to indoline] promotes the reaction [1,3-dichloro-2-propanol results in decreased expression of SLC7A11 protein]; more ...CTDPMID:35870111
Slc7a11Rat1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine multiple interactionsISORGD:131953164804641-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine promotes the reaction [ochratoxin A results in decreased expression of SLC7A11 protein]CTDPMID:38896176
Slc7a11Rat1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine decreases expressionISORGD:131953164804641-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine results in decreased expression of SLC7A11 proteinCTDPMID:38896176
Slc7a11Rat1-nitropyrene multiple interactionsISORGD:13195316480464CYP1B1 protein promotes the reaction [1-nitropyrene results in decreased expression of SLC7A11 protein]; ferrostatin-1 inhibits more ...CTDPMID:37993079
Slc7a11Rat1-nitropyrene decreases expressionISORGD:131953164804641-nitropyrene results in decreased expression of SLC7A11 proteinCTDPMID:37993079
Slc7a11Rat1-nitropyrene decreases expressionISORGD:131953264804641-nitropyrene results in decreased expression of SLC7A11 proteinCTDPMID:37993079

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Biological Process
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Original Reference(s)
Slc7a11Ratadult behavior acts_upstream_of_or_withinISORGD:13195321624291 PMID:29024663RGDPMID:29024663
Slc7a11Ratamino acid transmembrane transport involved_inIBACGD:CAL0000175765|FB:FBgn0002778|FB:FBgn0028425|MGI:1347355|MGI:1355323|MGI:1858261|MGI:1921337|PANTHER:PTN000208507|RGD:1309193|RGD:620639|SGD:S000001028|SGD:S000003287|UniProtKB:Q01650|UniProtKB:Q92536|UniProtKB:Q9UHI5|UniProtKB:Q9UM01|UniProtKB:Q9UPY5|WB:WBGene00000002|WB:WBGene000000041600115GO_REF:0000033GO_CentralGO_REF:0000033
Slc7a11Ratamino acid transmembrane transport involved_inIEAARBA:ARBA000270911600115GO_REF:0000117UniProtGO_REF:0000117
Slc7a11Ratamino acid transport involved_inIEAUniProtKB-KW:KW-00291600115GO_REF:0000043UniProtGO_REF:0000043
Slc7a11Ratamino acid transport involved_inIEAInterPro:IPR0047601600115GO_REF:0000002InterProGO_REF:0000002
Slc7a11Ratbrain development acts_upstream_of_or_withinISORGD:13195321624291MGI:1857061 PMID:17035536RGDPMID:17035536
Slc7a11Ratcellular response to oxidative stress acts_upstream_of_or_withinISORGD:13195321624291MGI:1857061|MGI:3608695 PMID:17035536, PMID:23085521RGDPMID:17035536|PMID:23085521
Slc7a11Ratcellular response to stress acts_upstream_of_or_withinISORGD:13195321624291 PMID:29024663RGDPMID:29024663
Slc7a11Ratdipeptide import across plasma membrane acts_upstream_of_or_withinISORGD:13195321624291MGI:1857061 PMID:16037214RGDPMID:16037214
Slc7a11Ratglutathione metabolic process acts_upstream_of_or_withinISORGD:13195321624291MGI:3608695 PMID:17200146, PMID:23085521RGDPMID:17200146|PMID:23085521
Slc7a11Ratglutathione transmembrane transport acts_upstream_of_or_withinISORGD:13195321624291 PMID:17035536RGDPMID:17035536
Slc7a11Ratintracellular glutamate homeostasis acts_upstream_of_or_withinISORGD:13195321624291MGI:1351339|MGI:3608695 PMID:21191088, PMID:29024663RGDPMID:21191088|PMID:29024663
Slc7a11RatL-cystine transport involved_inISORGD:13195311624291 PMID:11133847, PMID:11213471, PMID:11417227, PMID:15151999, PMID:34880232, PMID:35352032RGDPMID:11133847|PMID:11213471|PMID:11417227|PMID:15151999|PMID:34880232|PMID:35352032
Slc7a11RatL-cystine transport involved_inISORGD:13195321624291 PMID:16037214RGDPMID:16037214
Slc7a11RatL-glutamate import across plasma membrane acts_upstream_of_or_withinISORGD:13195321624291MGI:3608695 PMID:21490221RGDPMID:21490221
Slc7a11RatL-glutamate transmembrane transport involved_inISORGD:13195311624291 PMID:11133847, PMID:11417227, PMID:15151999, PMID:34880232, PMID:35352032RGDPMID:11133847|PMID:11417227|PMID:15151999|PMID:34880232|PMID:35352032
Slc7a11RatL-kynurenine transmembrane transport involved_inISORGD:13195311624291 PMID:35245456RGDPMID:35245456
Slc7a11Ratlens fiber cell differentiation  IEP 2315033 RGD 
Slc7a11Ratlimb development acts_upstream_of_or_withinISORGD:13195321624291MGI:3608695 PMID:21490221RGDPMID:21490221
Slc7a11Ratlung alveolus development acts_upstream_of_or_withinISORGD:13195321624291MGI:3608695 PMID:23085521RGDPMID:23085521
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Cellular Component
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Original Reference(s)
Slc7a11Ratapical part of cell located_inISORGD:13195321624291 PMID:16399997RGDPMID:16399997
Slc7a11Ratastrocyte projection located_inISORGD:13195321624291 PMID:16399997RGDPMID:16399997
Slc7a11Ratbrush border membrane located_inISORGD:13195321624291 PMID:16399997RGDPMID:16399997
Slc7a11Ratcell surface located_inISORGD:13195311624291 PMID:25063885RGDPMID:25063885
Slc7a11Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Slc7a11Ratmembrane located_inISORGD:13195321624291 PMID:29350434RGDPMID:29350434
Slc7a11Ratmembrane located_inIEAInterPro:IPR002293|InterPro:IPR0047601600115GO_REF:0000002InterProGO_REF:0000002
Slc7a11Ratplasma membrane located_inISORGD:13195321624291 PMID:16399997RGDPMID:16399997
Slc7a11Ratplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044
Slc7a11Ratplasma membrane located_inISORGD:13195311624291UniProtKB:P08195 PMID:11417227, PMID:15151999, PMID:34880232RGDPMID:11417227|PMID:15151999|PMID:34880232
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Molecular Function

  
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Original Reference(s)
Slc7a11Ratcystine:glutamate antiporter activity enablesISORGD:13195311624291 PMID:11417227, PMID:15151999, PMID:34120018, PMID:35245456, PMID:35352032RGDPMID:11417227|PMID:15151999|PMID:34120018|PMID:35245456|PMID:35352032
Slc7a11RatL-amino acid transmembrane transporter activity enablesIBAMGI:1298205|MGI:1355323|PANTHER:PTN000208507|SGD:S000001028|SGD:S000003287|UniProtKB:A0A3Q1NNN2|UniProtKB:P82251|UniProtKB:Q01650|UniProtKB:Q92536|UniProtKB:Q9UHI5|UniProtKB:Q9UPY51600115GO_REF:0000033GO_CentralGO_REF:0000033
Slc7a11RatL-kynurenine transmembrane transporter activity enablesISORGD:13195311624291 PMID:35245456RGDPMID:35245456
Slc7a11Ratprotein binding enablesISORGD:13195311624291UniProtKB:P08195|UniProtKB:P08195-4|UniProtKB:P16070|UniProtKB:Q07627|UniProtKB:Q8IUG1 PMID:21397861, PMID:32296183, PMID:34880232RGDPMID:21397861|PMID:32296183|PMID:34880232
Slc7a11Rattransmembrane transporter activity enablesIEAInterPro:IPR0022931600115GO_REF:0000002InterProGO_REF:0000002


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Reference Title
Reference Citation
1. Expression of the cystine-glutamate exchanger (xc-) in retinal ganglion cells and regulation by nitric oxide and oxidative stress. Dun Y, etal., Cell Tissue Res. 2006 May;324(2):189-202. Epub 2006 Jan 28.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. The role of cystine-glutamate exchange in nicotine dependence in rats and humans. Knackstedt LA, etal., Biol Psychiatry. 2009 May 15;65(10):841-5. Epub 2008 Dec 21.
5. Expression and developmental regulation of the cystine/glutamate exchanger (xc-) in the rat. La Bella V, etal., Neurochem Res. 2007 Jun;32(6):1081-90. Epub 2007 Mar 31.
6. Molecular characterization of the cystine/glutamate exchanger and the excitatory amino acid transporters in the rat lens. Lim J, etal., Invest Ophthalmol Vis Sci. 2005 Aug;46(8):2869-77.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Prognostic significance of amino-acid transporter expression (LAT1, ASCT2, and xCT) in surgically resected tongue cancer. Toyoda M, etal., Br J Cancer. 2014 May 13;110(10):2506-13. doi: 10.1038/bjc.2014.178. Epub 2014 Apr 24.
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PMID:8699821   PMID:16037214   PMID:16144837   PMID:16399997   PMID:17035536   PMID:17200146   PMID:17575980   PMID:17963724   PMID:19017641   PMID:21191088   PMID:21490221   PMID:21639880  
PMID:22095285   PMID:23085521   PMID:23192314   PMID:24548853   PMID:24687412   PMID:24866234   PMID:25063885   PMID:25429150   PMID:26851652   PMID:27570548   PMID:29024663   PMID:29038291  
PMID:29045497   PMID:29350434   PMID:29488137   PMID:34259984   PMID:35786456   PMID:36456793   PMID:36929608   PMID:37146710   PMID:37391124   PMID:37603538   PMID:37691947   PMID:37822721  
PMID:38816686   PMID:39354361  



Slc7a11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82136,532,912 - 136,668,560 (-)NCBIGRCr8
mRatBN7.22134,382,002 - 134,517,622 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2133,963,107 - 134,517,536 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2141,015,140 - 141,089,464 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02139,127,676 - 139,201,998 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02133,756,818 - 133,831,146 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02139,453,774 - 139,528,479 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2139,453,774 - 139,528,162 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02158,930,294 - 159,004,937 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42139,241,142 - 139,317,101 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12139,198,359 - 139,266,947 (-)NCBI
Celera2128,949,395 - 129,023,474 (-)NCBICelera
Cytogenetic Map2q26NCBI
SLC7A11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384138,164,097 - 138,312,671 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4138,164,097 - 138,242,349 (-)EnsemblGRCh38hg38GRCh38
GRCh374139,085,251 - 139,163,503 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364139,304,698 - 139,382,953 (-)NCBINCBI36Build 36hg18NCBI36
Build 344139,449,092 - 139,520,828NCBI
Celera4136,424,509 - 136,502,906 (-)NCBICelera
Cytogenetic Map4q28.3NCBI
HuRef4134,820,291 - 134,898,999 (-)NCBIHuRef
CHM1_14139,061,708 - 139,139,961 (-)NCBICHM1_1
T2T-CHM13v2.04141,487,564 - 141,636,430 (-)NCBIT2T-CHM13v2.0
Slc7a11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39350,319,385 - 50,403,947 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl349,846,975 - 50,398,063 (-)EnsemblGRCm39 Ensembl
GRCm38350,364,936 - 50,499,087 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl349,892,526 - 50,443,614 (-)EnsemblGRCm38mm10GRCm38
MGSCv37350,168,858 - 50,247,535 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36350,461,131 - 50,539,808 (-)NCBIMGSCv36mm8
Celera350,149,206 - 50,227,932 (-)NCBICelera
Cytogenetic Map3CNCBI
cM Map321.72NCBI
Slc7a11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554285,237,865 - 5,309,085 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554285,238,460 - 5,309,085 (+)NCBIChiLan1.0ChiLan1.0
SLC7A11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23136,031,904 - 136,178,341 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14136,428,877 - 136,575,218 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04130,529,677 - 130,601,396 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14141,841,526 - 141,919,678 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4141,849,343 - 141,959,849 (-)Ensemblpanpan1.1panPan2
SLC7A11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1194,289,792 - 4,379,060 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl194,289,850 - 4,389,048 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha194,539,704 - 4,608,064 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0194,364,717 - 4,454,499 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl194,264,457 - 4,464,477 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1194,293,544 - 4,361,949 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0194,655,537 - 4,724,650 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0195,019,875 - 5,088,260 (+)NCBIUU_Cfam_GSD_1.0
Slc7a11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530151,740,115 - 51,806,268 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365359,177,143 - 9,242,566 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365359,177,305 - 9,242,743 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC7A11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl888,608,174 - 88,687,250 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1888,608,083 - 88,690,589 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SLC7A11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1785,149,810 - 85,225,061 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl785,154,068 - 85,225,144 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603764,647,689 - 64,726,569 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc7a11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477718,546,799 - 18,619,947 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477718,540,006 - 18,619,881 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Slc7a11
751 total Variants

Predicted Target Of
Summary Value
Count of predictions:998
Count of miRNA genes:319
Interacting mature miRNAs:468
Transcripts:ENSRNOT00000014317
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 57 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2129164097152195315Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2122609194206936711Rat

1 to 10 of 57 rows
RH135019  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22134,443,162 - 134,443,349 (+)MAPPERmRatBN7.2
Rnor_6.02139,453,895 - 139,454,081NCBIRnor6.0
Rnor_5.02158,930,415 - 158,930,601UniSTSRnor5.0
RGSC_v3.42139,241,263 - 139,241,449UniSTSRGSC3.4
Celera2128,949,516 - 128,949,702UniSTS
RH 3.4 Map2822.8UniSTS
Cytogenetic Map2q26UniSTS


This gene Slc7a11 is modified in the following models/strains:
F344-Slc7a11Tn(sb-T2/Bart3)2.266Mcwi    




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 36 113 84 83 52 25 52 6 193 83 93 41 60 31



Ensembl Acc Id: ENSRNOT00000014317   ⟹   ENSRNOP00000014317
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2133,963,107 - 134,517,536 (-)Ensembl
Rnor_6.0 Ensembl2139,453,774 - 139,528,162 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114420   ⟹   ENSRNOP00000091221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2134,447,464 - 134,517,536 (-)Ensembl
RefSeq Acc Id: NM_001107673   ⟹   NP_001101143
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82136,593,952 - 136,668,264 (-)NCBI
mRatBN7.22134,443,042 - 134,517,358 (-)NCBI
Rnor_6.02139,453,774 - 139,528,162 (-)NCBI
Rnor_5.02158,930,294 - 159,004,937 (-)NCBI
RGSC_v3.42139,241,142 - 139,317,101 (-)RGD
Celera2128,949,395 - 129,023,474 (-)RGD
Sequence:
RefSeq Acc Id: XM_039102258   ⟹   XP_038958186
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82136,532,915 - 136,668,560 (-)NCBI
mRatBN7.22134,382,005 - 134,517,228 (-)NCBI
RefSeq Acc Id: XM_039102259   ⟹   XP_038958187
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82136,601,293 - 136,668,560 (-)NCBI
mRatBN7.22134,451,766 - 134,517,228 (-)NCBI
RefSeq Acc Id: XM_039102260   ⟹   XP_038958188
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82136,532,912 - 136,668,533 (-)NCBI
mRatBN7.22134,382,002 - 134,517,622 (-)NCBI
RefSeq Acc Id: XM_063281786   ⟹   XP_063137856
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82136,593,952 - 136,668,533 (-)NCBI
1 to 10 of 10 rows
Protein RefSeqs NP_001101143 (Get FASTA)   NCBI Sequence Viewer  
  XP_038958186 (Get FASTA)   NCBI Sequence Viewer  
  XP_038958187 (Get FASTA)   NCBI Sequence Viewer  
  XP_038958188 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137856 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM15001 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014317.5
  ENSRNOP00000091221
  ENSRNOP00000091221.1
  ENSRNOP00000098235
1 to 10 of 10 rows
RefSeq Acc Id: NP_001101143   ⟸   NM_001107673
- UniProtKB: D4ADU2 (UniProtKB/TrEMBL),   A0A8I6AB70 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014317   ⟸   ENSRNOT00000014317
RefSeq Acc Id: XP_038958188   ⟸   XM_039102260
- Peptide Label: isoform X3
- UniProtKB: D4ADU2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958186   ⟸   XM_039102258
- Peptide Label: isoform X1
- UniProtKB: D4ADU2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958187   ⟸   XM_039102259
- Peptide Label: isoform X2
- UniProtKB: D4ADU2 (UniProtKB/TrEMBL)

Name Modeler Protein Id AA Range Protein Structure
AF-D4ADU2-F1-model_v2 AlphaFold D4ADU2 1-502 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 21 of 21 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-53144 BioCyc
Ensembl Genes ENSRNOG00000010210 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014317.6 UniProtKB/TrEMBL
  ENSRNOT00000114420 ENTREZGENE
  ENSRNOT00000114420.1 UniProtKB/TrEMBL
  ENSRNOT00000120596 ENTREZGENE
Gene3D-CATH Amino acid/polyamine transporter I UniProtKB/TrEMBL
InterPro AA/rel_permease1 UniProtKB/TrEMBL
  AminoAcid_Transporter UniProtKB/TrEMBL
  L_AA_transporter UniProtKB/TrEMBL
KEGG Report rno:310392 UniProtKB/TrEMBL
NCBI Gene 310392 ENTREZGENE
PANTHER AMINO ACID TRANSPORTER UniProtKB/TrEMBL
  CYSTINE/GLUTAMATE TRANSPORTER UniProtKB/TrEMBL
Pfam AA_permease_2 UniProtKB/TrEMBL
PharmGKB SLC7A11 RGD
PhenoGen Slc7a11 PhenoGen
PIRSF AA_transporter UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010210 RatGTEx
UniProt A0A8I6AB70 ENTREZGENE, UniProtKB/TrEMBL
  D4ADU2 ENTREZGENE, UniProtKB/TrEMBL
1 to 21 of 21 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Slc7a11  solute carrier family 7 (cationic amino acid transporter, y+ system), member 11   Slc7a11_predicted  solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Slc7a11_predicted  solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 (predicted)      Symbol and Name status set to approved 70820 APPROVED