Ctsa (cathepsin A) - Rat Genome Database

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Gene: Ctsa (cathepsin A) Rattus norvegicus
Analyze
Symbol: Ctsa
Name: cathepsin A
RGD ID: 1309070
Description: Predicted to enable serine-type carboxypeptidase activity. Predicted to be involved in negative regulation of chaperone-mediated autophagy; proteolysis; and regulation of protein stability. Predicted to be located in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in galactosialidosis and lysosomal storage disease. Orthologous to human CTSA (cathepsin A); PARTICIPATES IN renin-angiotensin cascade pathway; INTERACTS WITH (+)-schisandrin B; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC296370; lysosomal protective protein; Ppgb; protective protein for beta-galactosidase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83173,988,443 - 173,994,320 (+)NCBIGRCr8
mRatBN7.23153,569,106 - 153,574,983 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3153,568,381 - 153,576,215 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3157,377,572 - 157,383,424 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03165,876,542 - 165,882,394 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03163,620,317 - 163,626,169 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03161,298,750 - 161,304,627 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3161,298,962 - 161,304,625 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03167,483,817 - 167,489,976 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43155,866,335 - 155,871,998 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13155,772,370 - 155,778,034 (+)NCBI
Celera3152,176,711 - 152,182,414 (+)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CtsaRatlysosomal storage disease  ISOCTSA (Homo sapiens)1599169 RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CtsaRatadenosine deaminase deficiency  ISOCTSA (Homo sapiens)8554872ClinVar Annotator: match by term: Severe combined immunodeficiency more ...ClinVarPMID:26255240 more ...
CtsaRatfocal epilepsy  ISOCTSA (Homo sapiens)8554872ClinVar Annotator: match by term: Focal-onset seizureClinVarPMID:32581362
CtsaRatgalactosialidosis  ISOCTSA (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10333491 more ...
CtsaRatgenetic disease  ISOCTSA (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:18937050 more ...
CtsaRatHydrops Fetalis  ISOCTSA (Homo sapiens)8554872ClinVar Annotator: match by term: Non-immune hydrops fetalisClinVarPMID:26036949
CtsaRatT-Cell Immunodeficiency, Recurrent Infections, and Autoimmunity with or without Cardiac Malformations  ISOCTSA (Homo sapiens)8554872ClinVar Annotator: match by term: T-cell immunodeficiency more ...ClinVarPMID:22174160 and PMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CtsaRatgalactosialidosis  ISOCTSA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CtsaRatgalactosialidosis  ISOCTSA (Homo sapiens)7240710 OMIM 

1 to 20 of 121 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CtsaRat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CTSA mRNA]CTDPMID:31150632
CtsaRat1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane multiple interactionsEXP 64804642 more ...CTDPMID:19414516
CtsaRat1,2-dichloroethane decreases expressionISOCtsa (Mus musculus)6480464ethylene dichloride results in decreased expression of CTSA mRNACTDPMID:28960355
CtsaRat1,2-dimethylhydrazine decreases expressionISOCtsa (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of CTSA mRNACTDPMID:22206623
CtsaRat1,2-dimethylhydrazine multiple interactionsISOCtsa (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of CTSA mRNACTDPMID:22206623
CtsaRat17alpha-ethynylestradiol increases expressionISOCtsa (Mus musculus)6480464Ethinyl Estradiol results in increased expression of CTSA mRNACTDPMID:17942748
CtsaRat17alpha-ethynylestradiol multiple interactionsISOCtsa (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CTSA mRNACTDPMID:17942748
CtsaRat17beta-estradiol increases expressionISOCtsa (Mus musculus)6480464Estradiol results in increased expression of CTSA mRNACTDPMID:15289156 and PMID:39298647
CtsaRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsEXP 6480464AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of CTSA mRNA]CTDPMID:21215274
CtsaRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of CTSA mRNACTDPMID:33387578
CtsaRat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of CTSA mRNACTDPMID:34747641
CtsaRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOCtsa (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CTSA mRNA and Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CTSA promoter]CTDPMID:17942748 and PMID:19654925
CtsaRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOCtsa (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of CTSA mRNACTDPMID:21570461
CtsaRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOCTSA (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of CTSA mRNACTDPMID:20106945 and PMID:21632981
CtsaRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of CTSA mRNACTDPMID:21215274
CtsaRat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of CTSA mRNACTDPMID:21346803
CtsaRat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of CTSA mRNACTDPMID:21346803
CtsaRat2-hydroxypropanoic acid decreases expressionISOCTSA (Homo sapiens)6480464Lactic Acid results in decreased expression of CTSA mRNACTDPMID:30851411
CtsaRat3',5'-cyclic AMP multiple interactionsEXP 64804642 more ...CTDPMID:19414516
CtsaRat4,4'-sulfonyldiphenol decreases expressionISOCtsa (Mus musculus)6480464bisphenol S results in decreased expression of CTSA mRNACTDPMID:39298647

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Biological Process
1 to 11 of 11 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CtsaRatbiological_process  ND 159840701/07: no relevant rat dataRGD 
CtsaRatnegative regulation of chaperone-mediated autophagy involved_inISOCTSA (Homo sapiens)1624291UniProtKB:P10619 and PMID:12505983RGDPMID:12505983
CtsaRatnegative regulation of chaperone-mediated autophagy involved_inIEAUniProtKB:P10619 and ensembl:ENSP000004936131600115GO_REF:0000107EnsemblGO_REF:0000107
CtsaRatnegative regulation of chaperone-mediated autophagy involved_inISOCtsa (Mus musculus)1624291 PMID:12505983RGDPMID:12505983
CtsaRatproteolysis involved_inISOCTSA (Homo sapiens)1624291 PMID:12505983RGDPMID:12505983
CtsaRatproteolysis involved_inIEAUniProtKB:P10619 and ensembl:ENSP000004936131600115GO_REF:0000107EnsemblGO_REF:0000107
CtsaRatproteolysis involved_inIEAInterPro:IPR0015631600115GO_REF:0000002InterProGO_REF:0000002
CtsaRatproteolysis involved_inIEAUniProtKB-KW:KW-06451600115GO_REF:0000043UniProtGO_REF:0000043
CtsaRatregulation of protein stability involved_inISOCTSA (Homo sapiens)1624291 PMID:12505983RGDPMID:12505983
CtsaRatregulation of protein stability involved_inIEAUniProtKB:P10619 and ensembl:ENSP000004936131600115GO_REF:0000107EnsemblGO_REF:0000107
CtsaRatregulation of protein stability involved_inISOCtsa (Mus musculus)1624291 PMID:12505983RGDPMID:12505983
1 to 11 of 11 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CtsaRatintracellular membrane-bounded organelle located_inIEAUniProtKB:P10619 and ensembl:ENSP000004936131600115GO_REF:0000107EnsemblGO_REF:0000107
CtsaRatintracellular membrane-bounded organelle located_inISOCTSA (Homo sapiens) and UniProtKB:P10619-11624291 RGDGO_REF:0000052

Molecular Function
1 to 9 of 9 rows

  
Object Symbol
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Term
Qualifier
Evidence
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Reference
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Source
Original Reference(s)
CtsaRatcarboxypeptidase activity enablesIEAUniProtKB-KW:KW-01211600115GO_REF:0000043UniProtGO_REF:0000043
CtsaRathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
CtsaRatpeptidase activity enablesIEAUniProtKB-KW:KW-06451600115GO_REF:0000043UniProtGO_REF:0000043
CtsaRatprotein binding enablesISOCtsa (Mus musculus)1624291PR:O35657 PMID:9425240RGDPMID:9425240
CtsaRatserine-type carboxypeptidase activity enablesISOCTSA (Homo sapiens)1624291 PMID:12505983 and PMID:1907282RGDPMID:12505983 and PMID:1907282
CtsaRatserine-type carboxypeptidase activity enablesIEAUniProtKB:P10619 and ensembl:ENSP000004936131600115GO_REF:0000107EnsemblGO_REF:0000107
CtsaRatserine-type carboxypeptidase activity enablesIBAMGI:1921867 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
CtsaRatserine-type carboxypeptidase activity enablesIEAUniRule:UR0001274631600115GO_REF:0000104UniProtGO_REF:0000104
CtsaRatserine-type carboxypeptidase activity enablesIEAInterPro:IPR001563 more ...1600115GO_REF:0000002InterProGO_REF:0000002
1 to 9 of 9 rows

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
CtsaRatrenin-angiotensin cascade pathway   IEA 6907045 KEGGrno:04614

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#
Reference Title
Reference Citation
1. Cathepsin A regulates chaperone-mediated autophagy through cleavage of the lysosomal receptor. Cuervo AM, etal., EMBO J. 2003 Jan 2;22(1):47-59.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Protective protein gene mutations in galactosialidosis. Shimmoto M, etal., J Clin Invest. 1993 Jun;91(6):2393-8.
1 to 11 of 11 rows
PMID:12477932   PMID:14651853   PMID:19056867   PMID:19946888   PMID:23376485   PMID:23533145   PMID:27032673  



Ctsa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83173,988,443 - 173,994,320 (+)NCBIGRCr8
mRatBN7.23153,569,106 - 153,574,983 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3153,568,381 - 153,576,215 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3157,377,572 - 157,383,424 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03165,876,542 - 165,882,394 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03163,620,317 - 163,626,169 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03161,298,750 - 161,304,627 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3161,298,962 - 161,304,625 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03167,483,817 - 167,489,976 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43155,866,335 - 155,871,998 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13155,772,370 - 155,778,034 (+)NCBI
Celera3152,176,711 - 152,182,414 (+)NCBICelera
Cytogenetic Map3q42NCBI
CTSA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382045,891,335 - 45,898,820 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2045,890,144 - 45,898,949 (+)EnsemblGRCh38hg38GRCh38
GRCh372044,519,974 - 44,527,459 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362043,952,998 - 43,960,866 (+)NCBINCBI36Build 36hg18NCBI36
Build 342043,953,612 - 43,960,863NCBI
Celera2041,231,053 - 41,238,921 (+)NCBICelera
Cytogenetic Map20q13.12NCBI
HuRef2041,261,571 - 41,269,436 (+)NCBIHuRef
CHM1_12044,422,715 - 44,430,579 (+)NCBICHM1_1
T2T-CHM13v2.02047,627,833 - 47,635,315 (+)NCBIT2T-CHM13v2.0
Ctsa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392164,674,792 - 164,682,952 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2164,674,793 - 164,682,952 (+)EnsemblGRCm39 Ensembl
GRCm382164,832,872 - 164,841,032 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2164,832,873 - 164,841,032 (+)EnsemblGRCm38mm10GRCm38
MGSCv372164,658,373 - 164,666,532 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362164,524,078 - 164,532,237 (+)NCBIMGSCv36mm8
Celera2170,770,535 - 170,778,698 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map285.27NCBI
Ctsa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544511,399,151 - 11,405,069 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544511,399,151 - 11,405,069 (-)NCBIChiLan1.0ChiLan1.0
CTSA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22151,631,610 - 51,640,169 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12051,625,703 - 51,633,277 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02042,229,064 - 42,237,627 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12043,315,722 - 43,324,671 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2043,316,530 - 43,324,671 (+)Ensemblpanpan1.1panPan2
CTSA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12433,183,090 - 33,189,248 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2433,183,090 - 33,189,248 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2432,710,110 - 32,716,269 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02433,893,407 - 33,899,565 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2433,893,230 - 33,902,559 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12433,151,886 - 33,158,036 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02433,267,003 - 33,273,167 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02433,806,176 - 33,812,343 (+)NCBIUU_Cfam_GSD_1.0
Ctsa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640191,677,621 - 191,683,147 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365147,130,848 - 7,136,536 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365147,131,263 - 7,136,775 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTSA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1748,082,448 - 48,089,971 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11748,082,480 - 48,089,971 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21753,729,009 - 53,736,612 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CTSA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1217,986,036 - 17,993,866 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl217,984,310 - 17,993,489 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605066,625,707 - 66,634,343 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ctsa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247908,686,027 - 8,691,898 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247908,686,027 - 8,692,119 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Ctsa
32 total Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
3 161299971 161299972 G C snv M520/N (MCW) View more Information

Predicted Target Of
Summary Value
Count of predictions:455
Count of miRNA genes:228
Interacting mature miRNAs:262
Transcripts:ENSRNOT00000066028
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 39 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3145925360166177555Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145925360166177555Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145956084157309487Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3145925360166177555Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3145925360166177555Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3145925360166177555Rat

1 to 10 of 39 rows
AA891893  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83173,993,661 - 173,994,060 (+)Marker Load Pipeline
mRatBN7.23153,574,324 - 153,574,723 (+)MAPPERmRatBN7.2
Rnor_6.03161,303,969 - 161,304,367NCBIRnor6.0
Rnor_5.03167,489,318 - 167,489,716UniSTSRnor5.0
RGSC_v3.43155,871,342 - 155,871,740UniSTSRGSC3.4
Celera3152,181,930 - 152,182,328UniSTS
RH 3.4 Map31424.1UniSTS
Cytogenetic Map3q42UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000066028   ⟹   ENSRNOP00000062425
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3153,568,381 - 153,574,978 (+)Ensembl
Rnor_6.0 Ensembl3161,298,962 - 161,304,625 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105075   ⟹   ENSRNOP00000097812
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3153,568,837 - 153,576,215 (+)Ensembl
RefSeq Acc Id: NM_001011959   ⟹   NP_001011959
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83173,988,443 - 173,994,320 (+)NCBI
mRatBN7.23153,569,106 - 153,574,983 (+)NCBI
Rnor_6.03161,298,750 - 161,304,627 (+)NCBI
Rnor_5.03167,483,817 - 167,489,976 (+)NCBI
RGSC_v3.43155,866,335 - 155,871,998 (+)RGD
Celera3152,176,711 - 152,182,414 (+)NCBI
Sequence:
Protein RefSeqs NP_001011959 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH78934 (Get FASTA)   NCBI Sequence Viewer  
  EDL96486 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000062425
  ENSRNOP00000062425.2
  ENSRNOP00000097812.1
RefSeq Acc Id: NP_001011959   ⟸   NM_001011959
- Peptide Label: precursor
- UniProtKB: F7EU44 (UniProtKB/TrEMBL),   A6JXC2 (UniProtKB/TrEMBL),   A6JXC3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000062425   ⟸   ENSRNOT00000066028
Ensembl Acc Id: ENSRNOP00000097812   ⟸   ENSRNOT00000105075

Name Modeler Protein Id AA Range Protein Structure
AF-Q6AYS3-F1-model_v2 AlphaFold Q6AYS3 1-456 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692668
Promoter ID:EPDNEW_R3193
Type:initiation region
Name:Ctsa_1
Description:cathepsin A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03161,298,913 - 161,298,973EPDNEW


1 to 27 of 27 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-46822 BioCyc
Ensembl Genes ENSRNOG00000015857 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066028 ENTREZGENE
  ENSRNOT00000066028.2 UniProtKB/TrEMBL
  ENSRNOT00000105075.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7108104 IMAGE-MGC_LOAD
InterPro AB_hydrolase UniProtKB/TrEMBL
  Peptidase_S10 UniProtKB/TrEMBL
  Ser_caboxypep_his_AS UniProtKB/TrEMBL
  Ser_caboxypep_ser_AS UniProtKB/TrEMBL
KEGG Report rno:296370 UniProtKB/TrEMBL
MGC_CLONE MGC:93743 IMAGE-MGC_LOAD
NCBI Gene 296370 ENTREZGENE
PANTHER LYSOSOMAL PROTECTIVE PROTEIN UniProtKB/TrEMBL
  PTHR11802 UniProtKB/TrEMBL
Pfam Peptidase_S10 UniProtKB/TrEMBL
PhenoGen Ctsa PhenoGen
PRINTS CRBOXYPTASEC UniProtKB/TrEMBL
PROSITE CARBOXYPEPT_SER_HIS UniProtKB/TrEMBL
  CARBOXYPEPT_SER_SER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015857 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/TrEMBL
UniProt A0A8I6ARV9_RAT UniProtKB/TrEMBL
  A6JXC2 ENTREZGENE, UniProtKB/TrEMBL
  A6JXC3 ENTREZGENE, UniProtKB/TrEMBL
  F7EU44 ENTREZGENE, UniProtKB/TrEMBL
1 to 27 of 27 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-08-05 Ctsa  cathepsin A  Ppgb  protective protein for beta-galactosidase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Ppgb  protective protein for beta-galactosidase  Ppgb_predicted  protective protein for beta-galactosidase (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Ppgb_predicted  protective protein for beta-galactosidase (predicted)      Symbol and Name status set to approved 70820 APPROVED