Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | USP25 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of USP25 mRNA | CTD | PMID:22079256 | (1->4)-beta-D-glucan | multiple interactions | ISO | Usp25 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of USP25 mRNA | CTD | PMID:36331819 | 1,2-dimethylhydrazine | multiple interactions | ISO | Usp25 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of USP25 mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | decreases expression | ISO | Usp25 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of USP25 mRNA | CTD | PMID:22206623 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Usp25 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of USP25 mRNA | CTD | PMID:19465110 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Usp25 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin affects the methylation of USP25 promoter] which results in increased expression of USP25 mRNA | CTD | PMID:33017471 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of USP25 mRNA | CTD | PMID:32109520 and PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Usp25 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of USP25 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of USP25 mRNA | CTD | PMID:21215274 and PMID:34747641 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 6-dinitrotoluene affects the expression of USP25 mRNA | CTD | PMID:21346803 | 3-chloropropane-1,2-diol | increases expression | EXP | | 6480464 | alpha-Chlorohydrin results in increased expression of USP25 protein | CTD | PMID:34915118 | acrolein | multiple interactions | ISO | USP25 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of USP25 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of USP25 mRNA | CTD | PMID:32699268 | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of USP25 mRNA | CTD | PMID:28959563 | all-trans-retinoic acid | increases expression | ISO | USP25 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of USP25 mRNA | CTD | PMID:21934132 and PMID:33167477 | all-trans-retinoic acid | increases expression | EXP | | 6480464 | Tretinoin results in increased expression of USP25 mRNA | CTD | PMID:20488242 | alpha-pinene | multiple interactions | ISO | USP25 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of USP25 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of USP25 mRNA | CTD | PMID:32699268 | amiodarone | increases expression | ISO | USP25 (Homo sapiens) | 6480464 | Amiodarone results in increased expression of USP25 mRNA | CTD | PMID:19774075 | antirheumatic drug | increases expression | ISO | USP25 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of USP25 mRNA | CTD | PMID:24449571 | aristolochic acid A | decreases expression | ISO | USP25 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of USP25 mRNA | CTD | PMID:33212167 | Aroclor 1254 | decreases expression | ISO | Usp25 (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of USP25 mRNA | CTD | PMID:23650126 | arsenite(3-) | multiple interactions | ISO | USP25 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to USP25 mRNA] | CTD | PMID:32406909 | benzo[a]pyrene | decreases expression | ISO | USP25 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of USP25 mRNA | CTD | PMID:20064835 | Benzo[k]fluoranthene | decreases expression | ISO | Usp25 (Mus musculus) | 6480464 | benzo(k)fluoranthene results in decreased expression of USP25 mRNA | CTD | PMID:26377693 | bis(2-chloroethyl) sulfide | increases expression | ISO | Usp25 (Mus musculus) | 6480464 | Mustard Gas results in increased expression of USP25 mRNA | CTD | PMID:15674844 | bisphenol A | decreases expression | ISO | USP25 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of USP25 mRNA | CTD | PMID:20678512 | bisphenol A | decreases methylation | ISO | USP25 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of USP25 gene | CTD | PMID:31601247 | bisphenol A | decreases expression | ISO | Usp25 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of USP25 mRNA | CTD | PMID:33221593 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of USP25 mRNA | CTD | PMID:30816183 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of USP25 mRNA | CTD | PMID:25181051 | butanal | decreases expression | ISO | USP25 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of USP25 mRNA | CTD | PMID:26079696 | cadmium atom | increases expression | ISO | USP25 (Homo sapiens) | 6480464 | Cadmium results in increased expression of USP25 mRNA | CTD | PMID:24376830 | CGP 52608 | multiple interactions | ISO | USP25 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to USP25 gene] | CTD | PMID:28238834 | chloroquine | multiple interactions | ISO | Usp25 (Mus musculus) | 6480464 | [Chloroquine co-treated with lipopolysaccharide more ... | CTD | PMID:28134560 | chloroquine | increases expression | ISO | Usp25 (Mus musculus) | 6480464 | Chloroquine results in increased expression of USP25 mRNA and Chloroquine results in increased expression of USP25 protein | CTD | PMID:28134560 | chlorpyrifos | decreases expression | ISO | Usp25 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of USP25 mRNA | CTD | PMID:37019170 | chromium(6+) | decreases expression | ISO | USP25 (Homo sapiens) | 6480464 | chromium hexavalent ion results in decreased expression of USP25 mRNA | CTD | PMID:30690063 | cisplatin | decreases expression | ISO | USP25 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of USP25 mRNA | CTD | PMID:27392435 | copper(II) sulfate | increases expression | ISO | USP25 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of USP25 mRNA | CTD | PMID:19549813 | cyclosporin A | increases expression | ISO | USP25 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of USP25 mRNA | CTD | PMID:20106945 and PMID:25562108 | DDT | decreases methylation | EXP | | 6480464 | DDT results in decreased methylation of USP25 gene | CTD | PMID:30207508 | dicrotophos | decreases expression | ISO | USP25 (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of USP25 mRNA | CTD | PMID:28302478 | dioxygen | increases expression | ISO | Usp25 (Mus musculus) | 6480464 | Oxygen deficiency results in increased expression of USP25 mRNA | CTD | PMID:22629407 | dioxygen | multiple interactions | ISO | Usp25 (Mus musculus) | 6480464 | Oxygen inhibits the reaction [Oxygen deficiency results in increased expression of USP25 mRNA] | CTD | PMID:22629407 | dorsomorphin | multiple interactions | ISO | USP25 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | entinostat | increases expression | ISO | USP25 (Homo sapiens) | 6480464 | entinostat results in increased expression of USP25 mRNA | CTD | PMID:26272509 | entinostat | multiple interactions | ISO | USP25 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of USP25 mRNA | CTD | PMID:27188386 | fenvalerate | increases expression | EXP | | 6480464 | fenvalerate results in increased expression of USP25 mRNA | CTD | PMID:30307764 | folic acid | decreases expression | ISO | Usp25 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of USP25 mRNA | CTD | PMID:25629700 | folic acid | multiple interactions | ISO | Usp25 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of USP25 mRNA | CTD | PMID:22206623 | formaldehyde | decreases expression | ISO | USP25 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of USP25 mRNA | CTD | PMID:23649840 | geldanamycin | increases expression | ISO | USP25 (Homo sapiens) | 6480464 | geldanamycin results in increased expression of USP25 mRNA | CTD | PMID:26705709 | genistein | decreases expression | ISO | Usp25 (Mus musculus) | 6480464 | Genistein results in decreased expression of USP25 mRNA | CTD | PMID:32186404 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of USP25 mRNA | CTD | PMID:33387578 | glafenine | decreases expression | EXP | | 6480464 | Glafenine results in decreased expression of USP25 mRNA | CTD | PMID:24136188 | methylmercury chloride | increases expression | ISO | USP25 (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of USP25 mRNA | CTD | PMID:28001369 | methylmercury chloride | decreases expression | ISO | USP25 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of USP25 mRNA | CTD | PMID:28001369 | ozone | multiple interactions | ISO | USP25 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of USP25 mRNA more ... | CTD | PMID:32699268 | paracetamol | increases expression | ISO | USP25 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of USP25 mRNA | CTD | PMID:29067470 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of USP25 mRNA | CTD | PMID:33387578 | pentachlorophenol | increases expression | ISO | Usp25 (Mus musculus) | 6480464 | Pentachlorophenol results in increased expression of USP25 mRNA | CTD | PMID:23892564 | perfluorooctane-1-sulfonic acid | decreases expression | ISO | USP25 (Homo sapiens) | 6480464 | perfluorooctane sulfonic acid results in decreased expression of USP25 mRNA | CTD | PMID:27153767 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Usp25 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of USP25 mRNA | CTD | PMID:36331819 | phenobarbital | affects expression | ISO | Usp25 (Mus musculus) | 6480464 | Phenobarbital affects the expression of USP25 mRNA | CTD | PMID:23091169 | phenylmercury acetate | increases expression | ISO | USP25 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of USP25 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | USP25 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of USP25 mRNA | CTD | PMID:27188386 | potassium chromate | multiple interactions | ISO | USP25 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of USP25 mRNA | CTD | PMID:22079256 | potassium chromate | decreases expression | ISO | USP25 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of USP25 mRNA | CTD | PMID:22079256 and PMID:22714537 | raloxifene | decreases expression | ISO | Usp25 (Mus musculus) | 6480464 | Raloxifene Hydrochloride results in decreased expression of USP25 mRNA | CTD | PMID:33269387 | SB 431542 | multiple interactions | ISO | USP25 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | sodium arsenate | increases expression | ISO | Usp25 (Mus musculus) | 6480464 | sodium arsenate results in increased expression of USP25 mRNA | CTD | PMID:21795629 | sodium arsenite | decreases expression | ISO | USP25 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of USP25 mRNA | CTD | PMID:28595984 and PMID:34032870 | sunitinib | increases expression | ISO | USP25 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of USP25 mRNA | CTD | PMID:31533062 | thimerosal | affects expression | ISO | USP25 (Homo sapiens) | 6480464 | Thimerosal affects the expression of USP25 mRNA | CTD | PMID:27188386 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of USP25 mRNA | CTD | PMID:34492290 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of USP25 mRNA | CTD | PMID:33387578 | trichostatin A | increases expression | ISO | USP25 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of USP25 mRNA | CTD | PMID:24935251 and PMID:26272509 | trichostatin A | multiple interactions | ISO | USP25 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of USP25 mRNA | CTD | PMID:27188386 | tunicamycin | decreases expression | ISO | Usp25 (Mus musculus) | 6480464 | Tunicamycin results in decreased expression of USP25 mRNA | CTD | PMID:17127020 | valproic acid | increases expression | ISO | Usp25 (Mus musculus) | 6480464 | Valproic Acid results in increased expression of USP25 mRNA | CTD | PMID:21427059 | valproic acid | affects expression | ISO | USP25 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of USP25 mRNA | CTD | PMID:25979313 | valproic acid | increases expression | ISO | USP25 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of USP25 mRNA | CTD | PMID:19101580 more ... | valproic acid | multiple interactions | ISO | USP25 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of USP25 mRNA | CTD | PMID:27188386 | vinclozolin | increases methylation | EXP | | 6480464 | vinclozolin results in increased methylation of USP25 gene | CTD | PMID:31682807 | vincristine | decreases expression | ISO | USP25 (Homo sapiens) | 6480464 | Vincristine results in decreased expression of USP25 mRNA | CTD | PMID:23649840 | |