Usp25 (ubiquitin specific peptidase 25) - Rat Genome Database

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Gene: Usp25 (ubiquitin specific peptidase 25) Rattus norvegicus
Analyze
Symbol: Usp25
Name: ubiquitin specific peptidase 25
RGD ID: 1309003
Description: Predicted to enable SUMO binding activity; cysteine-type deubiquitinase activity; and enzyme binding activity. Predicted to be involved in several processes, including interleukin-17-mediated signaling pathway; negative regulation of ERAD pathway; and protein modification process. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. Orthologous to human USP25 (ubiquitin specific peptidase 25); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC108348050; LOC304150; ubiquitin carboxyl-terminal hydrolase 25; ubiquitin carboxyl-terminal hydrolase 25-like; ubiquitin specific protease 25
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81129,088,283 - 29,198,323 (+)NCBIGRCr8
mRatBN7.21115,603,654 - 15,711,356 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1115,603,881 - 15,711,348 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1124,255,854 - 24,365,169 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01116,968,816 - 17,078,074 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01116,131,552 - 16,240,866 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01115,436,080 - 15,558,646 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1115,436,269 - 15,558,646 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1115,081,774 - 15,089,850 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01118,721,858 - 18,745,175 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01119,095,215 - 19,215,613 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41115,799,829 - 15,907,792 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11115,799,997 - 15,906,598 (+)NCBI
Celera1115,609,163 - 15,716,459 (+)NCBICelera
Cytogenetic Map11p11-q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp25RatAlzheimer's disease  ISOUSP25 (Homo sapiens)8554872ClinVar Annotator: match by term: Alzheimer diseaseClinVarPMID:16369530 more ...
Usp25RatIdiopathic Generalized Epilepsy 19  ISOUSP25 (Homo sapiens)8554872ClinVar Annotator: match by term: EPILEPSY more ...ClinVarPMID:38875478
Usp25RatNeurodevelopmental Disorders  ISOUSP25 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Usp25RatIdiopathic Generalized Epilepsy 19 susceptibilityISOUSP25 (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Usp25Rat(-)-epigallocatechin 3-gallate multiple interactionsISOUSP25 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of USP25 mRNACTDPMID:22079256
Usp25Rat(1->4)-beta-D-glucan multiple interactionsISOUsp25 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of USP25 mRNACTDPMID:36331819
Usp25Rat1,2-dimethylhydrazine multiple interactionsISOUsp25 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of USP25 mRNACTDPMID:22206623
Usp25Rat1,2-dimethylhydrazine decreases expressionISOUsp25 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of USP25 mRNACTDPMID:22206623
Usp25Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOUsp25 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of USP25 mRNACTDPMID:19465110
Usp25Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOUsp25 (Mus musculus)6480464[Tetrachlorodibenzodioxin affects the methylation of USP25 promoter] which results in increased expression of USP25 mRNACTDPMID:33017471
Usp25Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of USP25 mRNACTDPMID:32109520 and PMID:33387578
Usp25Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOUsp25 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of USP25 mRNACTDPMID:21570461
Usp25Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of USP25 mRNACTDPMID:21215274 and PMID:34747641
Usp25Rat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of USP25 mRNACTDPMID:21346803
Usp25Rat3-chloropropane-1,2-diol increases expressionEXP 6480464alpha-Chlorohydrin results in increased expression of USP25 proteinCTDPMID:34915118
Usp25Ratacrolein multiple interactionsISOUSP25 (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of USP25 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of USP25 mRNACTDPMID:32699268
Usp25Ratacrylamide increases expressionEXP 6480464Acrylamide results in increased expression of USP25 mRNACTDPMID:28959563
Usp25Ratall-trans-retinoic acid increases expressionISOUSP25 (Homo sapiens)6480464Tretinoin results in increased expression of USP25 mRNACTDPMID:21934132 and PMID:33167477
Usp25Ratall-trans-retinoic acid increases expressionEXP 6480464Tretinoin results in increased expression of USP25 mRNACTDPMID:20488242
Usp25Ratalpha-pinene multiple interactionsISOUSP25 (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of USP25 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of USP25 mRNACTDPMID:32699268
Usp25Ratamiodarone increases expressionISOUSP25 (Homo sapiens)6480464Amiodarone results in increased expression of USP25 mRNACTDPMID:19774075
Usp25Ratantirheumatic drug increases expressionISOUSP25 (Homo sapiens)6480464Antirheumatic Agents results in increased expression of USP25 mRNACTDPMID:24449571
Usp25Rataristolochic acid A decreases expressionISOUSP25 (Homo sapiens)6480464aristolochic acid I results in decreased expression of USP25 mRNACTDPMID:33212167
Usp25RatAroclor 1254 decreases expressionISOUsp25 (Mus musculus)6480464Chlorodiphenyl (54% Chlorine) results in decreased expression of USP25 mRNACTDPMID:23650126

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Biological Process
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Original Reference(s)
Usp25RatI-kappaB phosphorylation involved_inISOUsp25 (Mus musculus)1624291MGI:4332130 PMID:23042150RGDPMID:23042150
Usp25Ratimmune response involved_inISOUsp25 (Mus musculus)1624291MGI:4332130 PMID:23042150RGDPMID:23042150
Usp25Ratinterleukin-17-mediated signaling pathway involved_inISOUsp25 (Mus musculus)1624291MGI:4332130 PMID:23042150RGDPMID:23042150
Usp25RatmRNA metabolic process involved_inISOUsp25 (Mus musculus)1624291MGI:4332130 PMID:23042150RGDPMID:23042150
Usp25Ratnegative regulation of ERAD pathway involved_inISOUSP25 (Homo sapiens)1624291 PMID:22590560RGDPMID:22590560
Usp25Ratnegative regulation of ERAD pathway involved_inIEAUniProtKB:Q9UHP3 and ensembl:ENSP000003830441600115GO_REF:0000107EnsemblGO_REF:0000107
Usp25Ratnegative regulation of interleukin-17-mediated signaling pathway involved_inISOUSP25 (Homo sapiens)1624291 PMID:23042150RGDPMID:23042150
Usp25Ratnegative regulation of interleukin-17-mediated signaling pathway involved_inIEAUniProtKB:Q9UHP3 and ensembl:ENSP000003830441600115GO_REF:0000107EnsemblGO_REF:0000107
Usp25Ratnegative regulation of response to oxidative stress involved_inISOUSP25 (Homo sapiens)1624291 PMID:37339955RGDPMID:37339955
Usp25Ratnegative regulation of response to oxidative stress involved_inIEAUniProtKB:Q9UHP3 and ensembl:ENSP000003830441600115GO_REF:0000107EnsemblGO_REF:0000107
Usp25Ratprotein deubiquitination involved_inISOUSP25 (Homo sapiens)1624291 PMID:22590560RGDPMID:22590560
Usp25Ratprotein deubiquitination involved_inIEAUniProtKB:Q9UHP3 and ensembl:ENSP000003830441600115GO_REF:0000107EnsemblGO_REF:0000107
Usp25Ratprotein deubiquitination involved_inIEAInterPro:IPR0013941600115GO_REF:0000002InterProGO_REF:0000002
Usp25Ratprotein K48-linked deubiquitination involved_inISOUSP25 (Homo sapiens)1624291 PMID:18538659RGDPMID:18538659
Usp25Ratprotein K48-linked deubiquitination involved_inIEAUniProtKB:Q9UHP3 and ensembl:ENSP000003830441600115GO_REF:0000107EnsemblGO_REF:0000107
Usp25Ratprotein K63-linked deubiquitination involved_inISOUSP25 (Homo sapiens)1624291 PMID:18538659RGDPMID:18538659
Usp25Ratprotein K63-linked deubiquitination involved_inIEAUniProtKB:Q9UHP3 and ensembl:ENSP000003830441600115GO_REF:0000107EnsemblGO_REF:0000107
Usp25Ratproteolysis involved_inIEAUniProtKB-KW:KW-06451600115GO_REF:0000043UniProtGO_REF:0000043
Usp25Ratregulation of protein stability involved_inIBAFB:FBgn0016756 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Usp25Ratresponse to oxidative stress involved_inISOUsp25 (Mus musculus)1624291 PMID:23453926RGDPMID:23453926
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Cellular Component
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Object Symbol
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Reference
Notes
Source
Original Reference(s)
Usp25Ratcytoplasm is_active_inIEAUniProtKB:Q9UHP3 and ensembl:ENSP000003830441600115GO_REF:0000107EnsemblGO_REF:0000107
Usp25Ratcytoplasm located_inISOUSP25 (Homo sapiens)1624291 PMID:38875478RGDPMID:38875478
Usp25Ratcytoplasm is_active_inISOUSP25 (Homo sapiens)1624291 PMID:19440361 and PMID:2304215RGDPMID:19440361 and PMID:2304215
Usp25Ratcytosol located_inISOUSP25 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Usp25Ratcytosol is_active_inIBAFB:FBgn0016756 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Usp25Ratcytosol located_inIEAUniProtKB:Q9UHP3 and ensembl:ENSP000003830441600115GO_REF:0000107EnsemblGO_REF:0000107
Usp25Ratendoplasmic reticulum located_inISOUSP25 (Homo sapiens)1624291 PMID:22590560RGDPMID:22590560
Usp25Ratendoplasmic reticulum located_inIEAUniProtKB:Q9UHP3 and ensembl:ENSP000003830441600115GO_REF:0000107EnsemblGO_REF:0000107
Usp25Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Usp25Ratnucleus is_active_inIBAFB:FBgn0016756 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
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Molecular Function
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Original Reference(s)
Usp25RatATPase binding enablesISOUSP25 (Homo sapiens)1624291UniProtKB:P55072 and PMID:22590560RGDPMID:22590560
Usp25RatATPase binding enablesIEAUniProtKB:Q9UHP3 and ensembl:ENSP000003830441600115GO_REF:0000107EnsemblGO_REF:0000107
Usp25Ratcysteine-type deubiquitinase activity enablesISOUSP25 (Homo sapiens)1624291 PMID:18538659RGDPMID:18538659
Usp25Ratcysteine-type deubiquitinase activity enablesIBAFB:FBgn0005632 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Usp25Ratcysteine-type deubiquitinase activity enablesIEAUniProtKB:Q9UHP3 and ensembl:ENSP000003830441600115GO_REF:0000107EnsemblGO_REF:0000107
Usp25Ratcysteine-type deubiquitinase activity enablesIEAInterPro:IPR001394 and InterPro:IPR0182001600115GO_REF:0000002InterProGO_REF:0000002
Usp25Ratcysteine-type peptidase activity enablesIEAUniProtKB-KW:KW-07881600115GO_REF:0000043UniProtGO_REF:0000043
Usp25Ratdeubiquitinase activity enablesIEAUniProtKB:Q9UHP3 and ensembl:ENSP000003830441600115GO_REF:0000107EnsemblGO_REF:0000107
Usp25Ratdeubiquitinase activity enablesISOUSP25 (Homo sapiens)1624291 PMID:23042150 more ...RGDPMID:23042150 more ...
Usp25Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Usp25Ratpeptidase activity enablesIEAUniProtKB-KW:KW-06451600115GO_REF:0000043UniProtGO_REF:0000043
Usp25Ratprotein binding enablesISOUSP25 (Homo sapiens)1624291UniProtKB:O15481 more ...RGDPMID:18538659 more ...
Usp25RatSUMO binding enablesISOUSP25 (Homo sapiens)1624291UniProtKB:P63165 and PMID:18538659RGDPMID:18538659
Usp25RatSUMO binding enablesIEAUniProtKB:Q9UHP3 and ensembl:ENSP000003830441600115GO_REF:0000107EnsemblGO_REF:0000107
Usp25RatSUMO binding enablesIBAPANTHER:PTN008600562 and UniProtKB:Q9UHP31600115GO_REF:0000033GO_CentralGO_REF:0000033
Usp25Ratubiquitin protein ligase binding enablesISOUSP25 (Homo sapiens)1624291UniProtKB:Q86TM6 and PMID:22590560RGDPMID:22590560
Usp25Ratubiquitin protein ligase binding enablesIEAUniProtKB:Q9UHP3 and ensembl:ENSP000003830441600115GO_REF:0000107EnsemblGO_REF:0000107
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#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:18538659   PMID:22590560   PMID:22871113   PMID:35202642   PMID:37814350  



Usp25
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81129,088,283 - 29,198,323 (+)NCBIGRCr8
mRatBN7.21115,603,654 - 15,711,356 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1115,603,881 - 15,711,348 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1124,255,854 - 24,365,169 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01116,968,816 - 17,078,074 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01116,131,552 - 16,240,866 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01115,436,080 - 15,558,646 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1115,436,269 - 15,558,646 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1115,081,774 - 15,089,850 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01118,721,858 - 18,745,175 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01119,095,215 - 19,215,613 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41115,799,829 - 15,907,792 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11115,799,997 - 15,906,598 (+)NCBI
Celera1115,609,163 - 15,716,459 (+)NCBICelera
Cytogenetic Map11p11-q11NCBI
USP25
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382115,729,982 - 15,880,064 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2115,729,982 - 15,880,064 (+)EnsemblGRCh38hg38GRCh38
GRCh372117,102,301 - 17,252,383 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362116,024,367 - 16,174,248 (+)NCBINCBI36Build 36hg18NCBI36
Build 342116,024,366 - 16,174,248NCBI
Celera212,272,740 - 2,422,618 (+)NCBICelera
Cytogenetic Map21q21.1NCBI
HuRef212,481,855 - 2,631,589 (+)NCBIHuRef
CHM1_12116,663,002 - 16,812,990 (+)NCBICHM1_1
T2T-CHM13v2.02114,085,398 - 14,235,467 (+)NCBIT2T-CHM13v2.0
Usp25
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391676,810,573 - 76,913,671 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1676,810,594 - 76,913,668 (+)EnsemblGRCm39 Ensembl
GRCm381677,013,684 - 77,116,783 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1677,013,706 - 77,116,780 (+)EnsemblGRCm38mm10GRCm38
MGSCv371677,014,314 - 77,117,025 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361676,896,661 - 76,999,372 (+)NCBIMGSCv36mm8
Celera1677,241,870 - 77,344,813 (+)NCBICelera
Cytogenetic Map16C3.1NCBI
cM Map1644.4NCBI
Usp25
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540717,429,299 - 17,575,262 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540717,429,299 - 17,572,138 (+)NCBIChiLan1.0ChiLan1.0
USP25
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22212,219,944 - 12,367,486 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1217,053,528 - 7,201,118 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0212,468,993 - 2,618,200 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12115,834,158 - 15,982,182 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2115,724,729 - 15,982,182 (+)Ensemblpanpan1.1panPan2
USP25
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13112,555,614 - 12,692,765 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3112,555,595 - 12,691,694 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3112,567,579 - 12,704,519 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03112,582,490 - 12,719,684 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3112,582,034 - 12,718,862 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13112,553,996 - 12,690,361 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03112,592,012 - 12,728,277 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03112,989,867 - 13,126,766 (+)NCBIUU_Cfam_GSD_1.0
Usp25
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497113,693,817 - 13,762,699 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365058,548,677 - 8,681,232 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365058,613,588 - 8,683,560 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
USP25
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13180,571,342 - 180,712,435 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113180,571,019 - 180,708,966 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213190,890,832 - 191,008,377 (+)NCBISscrofa10.2Sscrofa10.2susScr3
USP25
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1276,660,926 - 76,805,153 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl276,662,159 - 76,791,688 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605077,159,534 - 77,305,841 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Usp25
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247454,169,938 - 4,305,122 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247454,170,328 - 4,306,604 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Usp25
775 total Variants

Predicted Target Of
Summary Value
Count of predictions:526
Count of miRNA genes:267
Interacting mature miRNAs:312
Transcripts:ENSRNOT00000002150
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
2290451Scl58Serum cholesterol level QTL 583.48blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)111283104625121472Rat
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11135331169Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
634341Bw121Body weight QTL 1213.56abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)11121836709Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000002150   ⟹   ENSRNOP00000002150
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1115,603,881 - 15,711,348 (+)Ensembl
Rnor_6.0 Ensembl1115,436,269 - 15,558,638 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000009911   ⟹   ENSRNOP00000009911
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1115,081,774 - 15,089,850 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084928   ⟹   ENSRNOP00000071094
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1115,624,409 - 15,711,348 (+)Ensembl
Rnor_6.0 Ensembl1115,436,382 - 15,558,646 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104051   ⟹   ENSRNOP00000080323
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1115,603,881 - 15,711,348 (+)Ensembl
RefSeq Acc Id: NM_001107114   ⟹   NP_001100584
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81129,090,653 - 29,198,316 (+)NCBI
mRatBN7.21115,603,695 - 15,711,349 (+)NCBI
Rnor_6.01115,436,269 - 15,558,638 (+)NCBI
Rnor_5.01119,095,215 - 19,215,613 (+)NCBI
RGSC_v3.41115,799,829 - 15,907,792 (+)RGD
Celera1115,609,163 - 15,716,459 (+)RGD
Sequence:
RefSeq Acc Id: XM_063270602   ⟹   XP_063126672
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81129,090,610 - 29,198,323 (+)NCBI
RefSeq Acc Id: XM_063270603   ⟹   XP_063126673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81129,090,655 - 29,198,323 (+)NCBI
RefSeq Acc Id: XM_063270604   ⟹   XP_063126674
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81129,090,610 - 29,195,322 (+)NCBI
RefSeq Acc Id: XM_063270605   ⟹   XP_063126675
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81129,088,283 - 29,198,323 (+)NCBI
1 to 11 of 11 rows
Protein RefSeqs NP_001100584 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126672 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126673 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126674 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126675 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM10593 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000002150
  ENSRNOP00000002150.4
  ENSRNOP00000071094.2
  ENSRNOP00000080323
  ENSRNOP00000080323.1
1 to 11 of 11 rows
RefSeq Acc Id: NP_001100584   ⟸   NM_001107114
- UniProtKB: D4ACD3 (UniProtKB/TrEMBL),   A6JL28 (UniProtKB/TrEMBL),   A0A0G2JZL5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071094   ⟸   ENSRNOT00000084928
Ensembl Acc Id: ENSRNOP00000002150   ⟸   ENSRNOT00000002150
Ensembl Acc Id: ENSRNOP00000009911   ⟸   ENSRNOT00000009911
Ensembl Acc Id: ENSRNOP00000080323   ⟸   ENSRNOT00000104051
USP

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZWN5-F1-model_v2 AlphaFold D3ZWN5 1-249 view protein structure
AF-D4ACD3-F1-model_v2 AlphaFold D4ACD3 1-1055 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 41 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-22182 BioCyc
Ensembl Genes ENSRNOG00000001573 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000050713 Ensembl
Ensembl Transcript ENSRNOT00000002150 ENTREZGENE
  ENSRNOT00000002150.7 UniProtKB/TrEMBL
  ENSRNOT00000084928.2 UniProtKB/TrEMBL
  ENSRNOT00000104051 ENTREZGENE
  ENSRNOT00000104051.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.250.1720 UniProtKB/TrEMBL
  Cysteine proteinases UniProtKB/TrEMBL
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/TrEMBL
InterPro Papain_like_cys_pep_sf UniProtKB/TrEMBL
  Pept_C19ubi-hydrolase_C_CS UniProtKB/TrEMBL
  Peptidase_C19 UniProtKB/TrEMBL
  Peptidase_C19 UniProtKB/TrEMBL
  UBA-like UniProtKB/TrEMBL
  UBA_8 UniProtKB/TrEMBL
  Ubiquitin-int_motif UniProtKB/TrEMBL
  UCH/PAN2 UniProtKB/TrEMBL
  USP25/28_UIM UniProtKB/TrEMBL
KEGG Report rno:304150 UniProtKB/TrEMBL
NCBI Gene 304150 ENTREZGENE
PANTHER UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UniProtKB/TrEMBL
  UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 25 UniProtKB/TrEMBL
Pfam UBA_8 UniProtKB/TrEMBL
  UCH UniProtKB/TrEMBL
  USP_UIM_N UniProtKB/TrEMBL
PhenoGen Usp25 PhenoGen
PROSITE UCH_2_1 UniProtKB/TrEMBL
  UCH_2_2 UniProtKB/TrEMBL
  UCH_2_3 UniProtKB/TrEMBL
  UIM UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001573 RatGTEx
  ENSRNOG00000050713 RatGTEx
SMART UIM UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/TrEMBL
  UBA_like UniProtKB/TrEMBL
UniProt A0A0G2JZL5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZPF8 ENTREZGENE, UniProtKB/TrEMBL
  A6JL28 ENTREZGENE, UniProtKB/TrEMBL
1 to 40 of 41 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Usp25  ubiquitin specific peptidase 25  LOC108348050  ubiquitin carboxyl-terminal hydrolase 25-like  Data merged from RGD:11392568 737654 PROVISIONAL
2016-08-02 LOC108348050  ubiquitin carboxyl-terminal hydrolase 25-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-04 Usp25  ubiquitin specific peptidase 25  Usp25_predicted  ubiquitin specific protease 25 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Usp25_predicted  ubiquitin specific protease 25 (predicted)      Symbol and Name status set to approved 70820 APPROVED