Cul3 (cullin 3) - Rat Genome Database

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Gene: Cul3 (cullin 3) Rattus norvegicus
Analyze
Symbol: Cul3
Name: cullin 3
RGD ID: 1308190
Description: Predicted to enable several functions, including Notch binding activity; POZ domain binding activity; and cyclin binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including positive regulation of cell cycle process; protein ubiquitination; and regulation of intracellular signal transduction. Predicted to act upstream of or within several processes, including anaphase-promoting complex-dependent catabolic process; embryonic morphogenesis; and fibroblast apoptotic process. Predicted to be located in several cellular components, including Golgi apparatus; microtubule cytoskeleton; and sperm flagellum. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in glutamatergic synapse. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Orthologous to human CUL3 (cullin 3); PARTICIPATES IN neddylation pathway; nuclear factor, erythroid 2 like 2 signaling pathway; proteasome degradation pathway involving cullin-dependent ubiquitin ligases; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cullin-3; LOC301555; MGC189292
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8989,040,987 - 89,118,775 (-)NCBIGRCr8
mRatBN7.2981,592,641 - 81,670,428 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl981,592,641 - 81,670,462 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx990,022,642 - 90,100,355 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0995,151,541 - 95,229,253 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0993,534,067 - 93,611,783 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0986,044,485 - 86,129,066 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl986,044,485 - 86,129,329 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0985,794,367 - 85,853,471 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4979,574,062 - 79,634,396 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1979,757,935 - 79,837,198 (-)NCBI
Celera979,070,793 - 79,129,030 (-)NCBICelera
Cytogenetic Map9q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Object Symbol
Species
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Original Reference(s)
Cul3Ratautism spectrum disorder  ISOCUL3 (Homo sapiens)8554872ClinVar Annotator: match by term: Autism spectrum disorderClinVarPMID:17576681 more ...
Cul3Ratautosomal dominant pseudohypoaldosteronism type 1  ISOCUL3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 and PMID:28492532
Cul3Ratdevelopmental and epileptic encephalopathy 11  ISOCUL3 (Homo sapiens)8554872ClinVar Annotator: match by term: Complex neurodevelopmental disorderClinVarPMID:25741868 and PMID:32341456
Cul3Ratgenetic disease  ISOCUL3 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 more ...
Cul3Ratintellectual disability  ISOCUL3 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVarPMID:25741868
Cul3RatNATURAL KILLER CELL ENTEROPATHY  ISOCUL3 (Homo sapiens)8554872ClinVar Annotator: match by term: NK-cell enteropathyClinVar 
Cul3RatNEURODEVELOPMENTAL DISORDER WITH OR WITHOUT AUTISM OR SEIZURES  ISOCUL3 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorder with or without autism or seizuresClinVarPMID:16199547 more ...
Cul3RatNeurodevelopmental Disorders  ISOCUL3 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
Cul3Ratpseudohypoaldosteronism  ISOCUL3 (Homo sapiens)8554872ClinVar Annotator: match by term: Hyperpotassemia and hypertension familialClinVarPMID:22266938
Cul3RatPseudohypoaldosteronism, Type IIA  ISOCUL3 (Homo sapiens)8554872ClinVar Annotator: match by term: Gordon hyperkalemia-hypertension syndromeClinVarPMID:22266938
Cul3RatPseudohypoaldosteronism, Type IIE  ISOCUL3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:17576681 more ...
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Original Reference(s)
Cul3Ratmelanoma  ISOCUL3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22535842
Cul3RatNeurodevelopmental Disorders  ISOCUL3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28191889
Cul3RatProstatic Neoplasms  ISOCUL3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29610475
Object Symbol
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Original Reference(s)
Cul3RatNEURODEVELOPMENTAL DISORDER WITH OR WITHOUT AUTISM OR SEIZURES  ISOCUL3 (Homo sapiens)7240710 OMIM 
Cul3RatPseudohypoaldosteronism, Type IIE  ISOCUL3 (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Cul3Rat1,2-dimethylhydrazine decreases expressionISOCul3 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of CUL3 mRNACTDPMID:22206623
Cul3Rat1,2-dimethylhydrazine multiple interactionsISOCul3 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of CUL3 mRNACTDPMID:22206623
Cul3Rat17beta-estradiol decreases expressionISOCul3 (Mus musculus)6480464Estradiol results in decreased expression of CUL3 mRNACTDPMID:30077407
Cul3Rat17beta-estradiol multiple interactionsISOCul3 (Mus musculus)6480464[Polyphenols co-treated with Estradiol] results in increased expression of CUL3 mRNACTDPMID:30077407
Cul3Rat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISOCUL3 (Homo sapiens)64804642 more ...CTDPMID:31675489
Cul3Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOCul3 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of CUL3 mRNACTDPMID:18691609
Cul3Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of CUL3 mRNACTDPMID:34747641
Cul3Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOCul3 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of CUL3 mRNACTDPMID:21570461
Cul3Rat2,4,6-tribromophenol decreases expressionISOCUL3 (Homo sapiens)64804642 more ...CTDPMID:31675489
Cul3Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of CUL3 mRNACTDPMID:21346803
Cul3Rat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of CUL3 mRNACTDPMID:21346803
Cul3Rat2-tert-butylhydroquinone multiple interactionsISOCUL3 (Homo sapiens)64804642-tert-butylhydroquinone inhibits the reaction [KEAP1 protein binds to CUL3 protein]CTDPMID:18417180
Cul3Rat2-tert-butylhydroquinone multiple interactionsISOCul3 (Mus musculus)64804642-tert-butylhydroquinone inhibits the reaction [KEAP1 protein binds to CUL3 protein]CTDPMID:30261176
Cul3Rat3,3',5,5'-tetrabromobisphenol A decreases expressionISOCUL3 (Homo sapiens)6480464tetrabromobisphenol A results in decreased expression of CUL3 proteinCTDPMID:31675489
Cul3Rat4,4'-sulfonyldiphenol increases expressionISOCUL3 (Homo sapiens)6480464bisphenol S results in increased expression of CUL3 proteinCTDPMID:34186270
Cul3Rat4-hydroxyphenyl retinamide decreases expressionISOCul3 (Mus musculus)6480464Fenretinide results in decreased expression of CUL3 mRNACTDPMID:28973697
Cul3Ratacrolein multiple interactionsISOCUL3 (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of CUL3 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of CUL3 mRNACTDPMID:32699268
Cul3Ratacrylamide increases expressionISOCUL3 (Homo sapiens)6480464Acrylamide results in increased expression of CUL3 mRNACTDPMID:32763439
Cul3Rataflatoxin B1 increases expressionISOCul3 (Mus musculus)6480464Aflatoxin B1 results in increased expression of CUL3 mRNACTDPMID:19770486
Cul3Ratalpha-pinene multiple interactionsISOCUL3 (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of CUL3 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of CUL3 mRNACTDPMID:32699268

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Biological Process
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Original Reference(s)
Cul3Ratanaphase-promoting complex-dependent catabolic process acts_upstream_of_or_withinISOCUL3 (Homo sapiens)1624291 PMID:10500095RGDPMID:10500095
Cul3Ratanaphase-promoting complex-dependent catabolic process acts_upstream_of_or_withinIEAUniProtKB:Q13618 and ensembl:ENSP000002644141600115GO_REF:0000107EnsemblGO_REF:0000107
Cul3Ratbiological_process  ND 159840710/2008: no relevant rat dataRGD 
Cul3Ratcell division involved_inIEAUniProtKB-KW:KW-01321600115GO_REF:0000043UniProtGO_REF:0000043
Cul3Ratcell migration involved_inIEAUniProtKB:Q13618 and ensembl:ENSP000002644141600115GO_REF:0000107EnsemblGO_REF:0000107
Cul3Ratcell migration involved_inISOCUL3 (Homo sapiens)1624291 PMID:19782033RGDPMID:19782033
Cul3Ratcell morphogenesis acts_upstream_of_or_withinISOCul3 (Mus musculus)1624291MGI:2651546 PMID:10500095RGDPMID:10500095
Cul3Ratcell morphogenesis acts_upstream_of_or_withinIEAUniProtKB:Q9JLV5 and ensembl:ENSMUSP000001307381600115GO_REF:0000107EnsemblGO_REF:0000107
Cul3Ratcell projection organization involved_inIEAUniProtKB-KW:KW-09701600115GO_REF:0000043UniProtGO_REF:0000043
Cul3Ratcellular response to amino acid stimulus involved_inISOCUL3 (Homo sapiens)1624291 PMID:29769719RGDPMID:29769719
Cul3Ratcellular response to amino acid stimulus involved_inIEAUniProtKB:Q13618 and ensembl:ENSP000002644141600115GO_REF:0000107EnsemblGO_REF:0000107
Cul3Ratcellular response to oxidative stress involved_inISOCUL3 (Homo sapiens)1624291 PMID:15601839RGDPMID:15601839
Cul3Ratcellular response to oxidative stress involved_inIEAUniProtKB:Q13618 and ensembl:ENSP000002644141600115GO_REF:0000107EnsemblGO_REF:0000107
Cul3RatCOPII vesicle coating involved_inISSUniProtKB:Q136181600115GO_REF:0000024UniProtGO_REF:0000024
Cul3RatCOPII vesicle coating involved_inISOCUL3 (Homo sapiens)1624291 PMID:22358839RGDPMID:22358839
Cul3RatCOPII vesicle coating involved_inIEAUniProtKB:Q13618 and ensembl:ENSP000002644141600115GO_REF:0000107EnsemblGO_REF:0000107
Cul3Ratembryonic cleavage involved_inISOCul3 (Mus musculus)1624291 PMID:22358839RGDPMID:22358839
Cul3Ratembryonic cleavage involved_inIEAUniProtKB:Q9JLV5 and ensembl:ENSMUSP000001307381600115GO_REF:0000107EnsemblGO_REF:0000107
Cul3Ratembryonic cleavage involved_inISSUniProtKB:Q9JLV51600115GO_REF:0000024UniProtGO_REF:0000024
Cul3Ratendoplasmic reticulum to Golgi vesicle-mediated transport involved_inISOCUL3 (Homo sapiens)1624291 PMID:22358839RGDPMID:22358839
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Cellular Component
1 to 20 of 52 rows

  
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Original Reference(s)
Cul3Ratcell projection located_inIEAUniProtKB-KW:KW-09661600115GO_REF:0000043UniProtGO_REF:0000043
Cul3Ratcentrosome located_inIEAUniProtKB:Q13618 and ensembl:ENSP000002644141600115GO_REF:0000107EnsemblGO_REF:0000107
Cul3Ratcentrosome located_inIEAUniProtKB-SubCell:SL-00481600115GO_REF:0000044UniProtGO_REF:0000044
Cul3Ratcentrosome located_inISOCUL3 (Homo sapiens)1624291 PMID:23213400RGDPMID:23213400
Cul3Ratcentrosome located_inISSUniProtKB:Q136181600115GO_REF:0000024UniProtGO_REF:0000024
Cul3Ratcilium located_inIEAUniProtKB-KW:KW-09691600115GO_REF:0000043UniProtGO_REF:0000043
Cul3RatCul3-RING ubiquitin ligase complex part_ofISSUniProtKB:Q136181600115GO_REF:0000024UniProtGO_REF:0000024
Cul3RatCul3-RING ubiquitin ligase complex part_ofISOCUL3 (Homo sapiens)1624291 PMID:14528312 more ...RGDPMID:14528312 more ...
Cul3RatCul3-RING ubiquitin ligase complex part_ofIBAFB:FBgn0261268 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cul3RatCul3-RING ubiquitin ligase complex part_ofIEAUniProtKB:Q13618 and ensembl:ENSP000002644141600115GO_REF:0000107EnsemblGO_REF:0000107
Cul3Ratcullin-RING ubiquitin ligase complex part_ofIEAInterPro:IPR0161571600115GO_REF:0000002InterProGO_REF:0000002
Cul3Ratcytoplasm located_inISOCUL3 (Homo sapiens)1624291 PMID:28395323RGDPMID:28395323
Cul3Ratcytoplasm located_inIEAUniProtKB:Q13618 and ensembl:ENSP000002644141600115GO_REF:0000107EnsemblGO_REF:0000107
Cul3Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Cul3Ratcytoplasm located_inISOCul3 (Mus musculus)1624291 PMID:24863065RGDPMID:24863065
Cul3Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Cul3Ratcytoplasm located_inIEAUniProtKB:Q9JLV5 and ensembl:ENSMUSP000001307381600115GO_REF:0000107EnsemblGO_REF:0000107
Cul3Ratcytoplasm located_inISSUniProtKB:Q136181600115GO_REF:0000024UniProtGO_REF:0000024
Cul3Ratcytoplasm is_active_inISOCUL3 (Homo sapiens)1624291 PMID:27708159RGDPMID:27708159
Cul3Ratcytoskeleton located_inIEAUniProtKB-KW:KW-02061600115GO_REF:0000043UniProtGO_REF:0000043
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Molecular Function
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Original Reference(s)
Cul3Ratcyclin binding enablesIEAUniProtKB:Q9JLV5 and ensembl:ENSMUSP000001307381600115GO_REF:0000107EnsemblGO_REF:0000107
Cul3Ratcyclin binding enablesISOCul3 (Mus musculus)1624291PR:Q61457 PMID:10500095RGDPMID:10500095
Cul3Ratidentical protein binding enablesIEAUniProtKB:Q9JLV5 and ensembl:ENSMUSP000001307381600115GO_REF:0000107EnsemblGO_REF:0000107
Cul3Ratidentical protein binding enablesISOCul3 (Mus musculus)1624291PR:Q9JLV5 PMID:22709582RGDPMID:22709582
Cul3RatNotch binding enablesISOCUL3 (Homo sapiens)1624291UniProtKB:P46531 and PMID:25401743RGDPMID:25401743
Cul3RatNotch binding enablesIEAUniProtKB:Q13618 and ensembl:ENSP000002644141600115GO_REF:0000107EnsemblGO_REF:0000107
Cul3RatPOZ domain binding enablesISOCUL3 (Homo sapiens)1624291 PMID:14528312 and PMID:19261606RGDPMID:14528312 and PMID:19261606
Cul3RatPOZ domain binding enablesIEAUniProtKB:Q13618 and ensembl:ENSP000002644141600115GO_REF:0000107EnsemblGO_REF:0000107
Cul3RatPOZ domain binding enablesISSUniProtKB:Q136181600115GO_REF:0000024UniProtGO_REF:0000024
Cul3Ratprotein binding enablesIPIUniProtKB:Q8K4308553595PMID:17062563UniProt 
Cul3Ratprotein binding enablesISOCul3 (Mus musculus)1624291PR:E9Q9D5 more ...RGDPMID:22709582 more ...
Cul3Ratprotein binding enablesISOCUL3 (Homo sapiens)1624291UniProtKB:O00154 more ...RGDPMID:12609982 more ...
Cul3Ratprotein binding enablesISOCUL3 (Homo sapiens) and UniProtKB:Q13618-11624291UniProtKB:Q8IWE4 and PMID:19617556RGDPMID:19617556
Cul3Ratubiquitin ligase complex scaffold activity enablesIEAUniProtKB:Q13618 and ensembl:ENSP000002644141600115GO_REF:0000107EnsemblGO_REF:0000107
Cul3Ratubiquitin ligase complex scaffold activity enablesISOCUL3 (Homo sapiens)1624291 PMID:15601839 more ...RGDPMID:15601839 more ...
Cul3Ratubiquitin protein ligase activity enablesISOCUL3 (Homo sapiens)1624291 PMID:14528312RGDPMID:14528312
Cul3Ratubiquitin protein ligase activity enablesIEAUniProtKB:Q13618 and ensembl:ENSP000002644141600115GO_REF:0000107EnsemblGO_REF:0000107
Cul3Ratubiquitin protein ligase binding enablesIEAUniProtKB:Q13618 and ensembl:ENSP000002644141600115GO_REF:0000107EnsemblGO_REF:0000107
Cul3Ratubiquitin protein ligase binding enablesIBAPANTHER:PTN002631076 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cul3Ratubiquitin protein ligase binding enablesISOCUL3 (Homo sapiens)1624291UniProtKB:P62877 and PMID:14528312RGDPMID:14528312
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RGD Manual Annotations


  

Imported Annotations - KEGG (archival)

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Original Reference(s)
Cul3Ratubiquitin/proteasome degradation pathway  IEA 6907045 KEGGrno:04120

Imported Annotations - PID (archival)

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Original Reference(s)
Cul3RatWnt signaling, canonical pathway   ISOCUL3 (Homo sapiens)6484113 PIDPID:200077

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Reference Title
Reference Citation
1. BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase. Furukawa M and Xiong Y, Mol Cell Biol. 2005 Jan;25(1):162-71.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Hayes JD and Dinkova-Kostova AT, Trends Biochem Sci. 2014 Apr;39(4):199-218. doi: 10.1016/j.tibs.2014.02.002. Epub 2014 Mar 16.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. Neddylation and deneddylation of CUL-3 is required to target MEI-1/Katanin for degradation at the meiosis-to-mitosis transition in C. elegans. Pintard L, etal., Curr Biol. 2003 May 27;13(11):911-21.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Actinfilin is a Cul3 substrate adaptor, linking GluR6 kainate receptor subunits to the ubiquitin-proteasome pathway. Salinas GD, etal., J Biol Chem. 2006 Dec 29;281(52):40164-73. Epub 2006 Oct 24.
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PMID:10500095   PMID:12477932   PMID:14528312   PMID:15983046   PMID:17339333   PMID:17543862   PMID:19056867   PMID:19056892   PMID:19158078   PMID:19261606   PMID:19782033   PMID:19946888  
PMID:19995937   PMID:20389280   PMID:20811152   PMID:22358839   PMID:22578813   PMID:22709582   PMID:22871113   PMID:23213400   PMID:23453970   PMID:23455478   PMID:23576762   PMID:24768539  
PMID:24844779   PMID:24863065   PMID:25002582   PMID:25401743   PMID:26399832   PMID:27561354   PMID:27708159   PMID:28395323   PMID:34036379   PMID:36720302  



Cul3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8989,040,987 - 89,118,775 (-)NCBIGRCr8
mRatBN7.2981,592,641 - 81,670,428 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl981,592,641 - 81,670,462 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx990,022,642 - 90,100,355 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0995,151,541 - 95,229,253 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0993,534,067 - 93,611,783 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0986,044,485 - 86,129,066 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl986,044,485 - 86,129,329 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0985,794,367 - 85,853,471 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4979,574,062 - 79,634,396 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1979,757,935 - 79,837,198 (-)NCBI
Celera979,070,793 - 79,129,030 (-)NCBICelera
Cytogenetic Map9q34NCBI
CUL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382224,470,150 - 224,585,363 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2224,470,150 - 224,585,397 (-)EnsemblGRCh38hg38GRCh38
GRCh372225,334,867 - 225,450,080 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362225,043,113 - 225,158,358 (-)NCBINCBI36Build 36hg18NCBI36
Build 342225,160,373 - 225,275,619NCBI
Celera2219,099,731 - 219,215,637 (-)NCBICelera
Cytogenetic Map2q36.2NCBI
HuRef2217,186,560 - 217,301,844 (-)NCBIHuRef
CHM1_12225,341,500 - 225,456,770 (-)NCBICHM1_1
T2T-CHM13v2.02224,952,401 - 225,067,578 (-)NCBIT2T-CHM13v2.0
Cul3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39180,242,640 - 80,318,426 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl180,242,640 - 80,318,197 (-)EnsemblGRCm39 Ensembl
GRCm38180,264,923 - 80,340,690 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl180,264,923 - 80,340,480 (-)EnsemblGRCm38mm10GRCm38
MGSCv37180,263,393 - 80,337,005 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36180,145,842 - 80,219,467 (-)NCBIMGSCv36mm8
Celera180,291,823 - 80,365,420 (-)NCBICelera
Cytogenetic Map1C5NCBI
cM Map141.24NCBI
Cul3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554539,564,522 - 9,629,976 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554539,546,554 - 9,629,976 (+)NCBIChiLan1.0ChiLan1.0
CUL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213127,089,437 - 127,200,964 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B127,104,406 - 127,215,480 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B111,714,533 - 111,827,080 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B230,289,195 - 230,373,537 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B230,289,195 - 230,378,991 (-)Ensemblpanpan1.1panPan2
CUL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12537,730,903 - 37,819,851 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2537,733,229 - 37,800,886 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2538,338,004 - 38,427,804 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02537,967,156 - 38,056,983 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2537,968,235 - 38,057,261 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12537,907,667 - 37,997,226 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02537,748,392 - 37,838,350 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02537,923,140 - 38,012,960 (-)NCBIUU_Cfam_GSD_1.0
Cul3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303179,724,396 - 179,788,614 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365696,065,367 - 6,132,316 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365696,067,230 - 6,131,467 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CUL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15126,189,851 - 126,287,005 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115126,191,605 - 126,287,148 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215139,621,601 - 139,781,465 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CUL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110110,425,895 - 110,541,431 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10110,425,076 - 110,541,538 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604088,866,367 - 88,980,363 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cul3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624823766,780 - 852,727 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624823767,347 - 854,065 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Cul3
336 total Variants

Predicted Target Of
Summary Value
Count of predictions:222
Count of miRNA genes:160
Interacting mature miRNAs:183
Transcripts:ENSRNOT00000021528
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 26 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat

1 to 10 of 26 rows
AI072520  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2981,593,418 - 81,593,612 (+)MAPPERmRatBN7.2
Rnor_6.0986,045,263 - 86,045,456NCBIRnor6.0
Rnor_5.0985,795,145 - 85,795,338UniSTSRnor5.0
RGSC_v3.4979,574,840 - 79,575,033UniSTSRGSC3.4
Celera979,071,571 - 79,071,764UniSTS
RH 3.4 Map9716.8UniSTS
Cytogenetic Map9q34UniSTS
CUL3-1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8989,057,250 - 89,057,807 (+)Marker Load Pipeline
mRatBN7.2981,608,905 - 81,609,462 (+)MAPPERmRatBN7.2
Rnor_6.0986,060,749 - 86,061,305NCBIRnor6.0
Rnor_5.0985,810,631 - 85,811,187UniSTSRnor5.0
RGSC_v3.4979,590,326 - 79,590,882UniSTSRGSC3.4
Celera979,087,057 - 79,087,613UniSTS
Cytogenetic Map9q34UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000021528   ⟹   ENSRNOP00000021528
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl981,592,641 - 81,669,996 (-)Ensembl
Rnor_6.0 Ensembl986,044,485 - 86,103,158 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093554
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl986,069,805 - 86,129,329 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093730   ⟹   ENSRNOP00000076209
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl981,592,641 - 81,670,462 (-)Ensembl
Rnor_6.0 Ensembl986,046,187 - 86,129,073 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097044   ⟹   ENSRNOP00000086948
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl981,592,641 - 81,670,462 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118892   ⟹   ENSRNOP00000097410
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl981,592,641 - 81,670,462 (-)Ensembl
RefSeq Acc Id: NM_001106923   ⟹   NP_001100393
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8989,040,987 - 89,118,427 (-)NCBI
mRatBN7.2981,592,641 - 81,670,085 (-)NCBI
Rnor_6.0986,044,485 - 86,103,158 (-)NCBI
Rnor_5.0985,794,367 - 85,853,471 (-)NCBI
RGSC_v3.4979,574,062 - 79,634,396 (-)RGD
Celera979,070,793 - 79,129,030 (-)RGD
Sequence:
RefSeq Acc Id: XM_008767227   ⟹   XP_008765449
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8989,042,672 - 89,098,692 (-)NCBI
mRatBN7.2981,593,141 - 81,650,350 (-)NCBI
Rnor_6.0986,044,980 - 86,101,995 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596376   ⟹   XP_017451865
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8989,042,672 - 89,118,775 (-)NCBI
mRatBN7.2981,593,141 - 81,670,428 (-)NCBI
Rnor_6.0986,044,980 - 86,129,064 (-)NCBI
Sequence:
1 to 9 of 9 rows
Protein RefSeqs NP_001100393 (Get FASTA)   NCBI Sequence Viewer  
  XP_008765449 (Get FASTA)   NCBI Sequence Viewer  
  XP_017451865 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI68969 (Get FASTA)   NCBI Sequence Viewer  
  B5DF89 (Get FASTA)   NCBI Sequence Viewer  
  EDL75493 (Get FASTA)   NCBI Sequence Viewer  
  EDL75494 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000086948
  ENSRNOP00000097410
1 to 9 of 9 rows
RefSeq Acc Id: NP_001100393   ⟸   NM_001106923
- UniProtKB: B5DF89 (UniProtKB/Swiss-Prot),   A6JW85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765449   ⟸   XM_008767227
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ASL8 (UniProtKB/TrEMBL),   A0A1W2Q6C6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451865   ⟸   XM_017596376
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A4V1 (UniProtKB/TrEMBL),   A0A1W2Q6C6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021528   ⟸   ENSRNOT00000021528
Ensembl Acc Id: ENSRNOP00000076209   ⟸   ENSRNOT00000093730
Cullin family profile   Cullin neddylation

Name Modeler Protein Id AA Range Protein Structure
AF-B5DF89-F1-model_v2 AlphaFold B5DF89 1-768 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13696799
Promoter ID:EPDNEW_R7319
Type:multiple initiation site
Name:Cul3_1
Description:cullin 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0986,129,293 - 86,129,353EPDNEW


1 to 35 of 35 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-27004 BioCyc
Ensembl Genes ENSRNOG00000015633 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000097044 ENTREZGENE
  ENSRNOT00000118892 ENTREZGENE
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot
  Cullin Repeats UniProtKB/Swiss-Prot
  Cullin, Chain C, Domain 2 UniProtKB/Swiss-Prot
InterPro Cullin UniProtKB/Swiss-Prot
  Cullin_CS UniProtKB/Swiss-Prot
  Cullin_homology UniProtKB/Swiss-Prot
  Cullin_homology_sf UniProtKB/Swiss-Prot
  Cullin_N UniProtKB/Swiss-Prot
  Cullin_neddylation_domain UniProtKB/Swiss-Prot
  Cullin_repeat-like_dom_sf UniProtKB/Swiss-Prot
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot
  WH_DNA-bd_sf UniProtKB/Swiss-Prot
NCBI Gene 301555 ENTREZGENE
PANTHER PTHR11932 UniProtKB/Swiss-Prot
Pfam Cullin UniProtKB/Swiss-Prot
  Cullin_Nedd8 UniProtKB/Swiss-Prot
PhenoGen Cul3 PhenoGen
PROSITE CULLIN_1 UniProtKB/Swiss-Prot
  CULLIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015633 RatGTEx
SMART CULLIN UniProtKB/Swiss-Prot
  Cullin_Nedd8 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot
  SSF74788 UniProtKB/Swiss-Prot
  SSF75632 UniProtKB/Swiss-Prot
UniProt A0A0G2JSP3_RAT UniProtKB/TrEMBL
  A0A1W2Q6C6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A4V1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ASL8 ENTREZGENE, UniProtKB/TrEMBL
  A6JW85 ENTREZGENE, UniProtKB/TrEMBL
  B5DF89 ENTREZGENE, UniProtKB/Swiss-Prot
1 to 35 of 35 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Cul3  cullin 3   Cul3_predicted  cullin 3 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Cul3_predicted  cullin 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED