Otud7b (OTU deubiquitinase 7B) - Rat Genome Database

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Gene: Otud7b (OTU deubiquitinase 7B) Rattus norvegicus
Analyze
Symbol: Otud7b
Name: OTU deubiquitinase 7B
RGD ID: 1308111
Description: Predicted to enable K48-linked deubiquitinase activity; K63-linked polyubiquitin modification-dependent protein binding activity; and cysteine-type deubiquitinase activity. Predicted to be involved in several processes, including negative regulation of protein localization to nucleus; protein deubiquitination; and regulation of intracellular signal transduction. Predicted to act upstream of or within in utero embryonic development and protein deubiquitination. Predicted to be active in cytoplasm and nucleus. Orthologous to human OTUD7B (OTU deubiquitinase 7B); INTERACTS WITH 1,2-dimethylhydrazine; 2,2',4,4'-Tetrabromodiphenyl ether; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cellular zinc finger anti-NF-kappaB Cezanne; LOC310677; OTU domain containing 7B; OTU domain-containing protein 7B; RGD1308111; similar to zinc finger protein Cezanne
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82186,350,811 - 186,411,461 (+)NCBIGRCr8
mRatBN7.22183,661,955 - 183,722,584 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2183,662,163 - 183,718,674 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2191,325,797 - 191,384,171 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02189,130,056 - 189,188,470 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02183,958,342 - 184,016,709 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02198,231,353 - 198,302,220 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2198,231,291 - 198,300,201 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02217,720,895 - 217,789,205 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42190,905,522 - 190,964,454 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12190,868,275 - 190,938,314 (+)NCBI
Celera2176,190,012 - 176,247,856 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Otud7bRatcataract 46 juvenile-onset  ISOOTUD7B (Homo sapiens)8554872ClinVar Annotator: match by term: Cataract 46 juvenile-onsetClinVarPMID:29464339 and PMID:31690835
Otud7bRatgastrointestinal stromal tumor  ISOOTUD7B (Homo sapiens)8554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
Otud7bRatimmunodeficiency 42  ISOOTUD7B (Homo sapiens)8554872ClinVar Annotator: match by term: Autosomal recessive mendelian susceptibility to mycobacterial diseases due to complete RORgamma receptor deficiencyClinVarPMID:28492532
Otud7bRatMHC class II deficiency  ISOOTUD7B (Homo sapiens)8554872ClinVar Annotator: match by term: MHC class II deficiencyClinVarPMID:28492532
Otud7bRatparathyroid carcinoma  ISOOTUD7B (Homo sapiens)8554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532
Otud7bRatsevere congenital neutropenia 3  ISOOTUD7B (Homo sapiens)8554872ClinVar Annotator: match by term: Kostmann syndromeClinVarPMID:28492532
Otud7bRatsevere congenital neutropenia 5  ISOOTUD7B (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital neutropenia-myelofibrosis-nephromegaly syndromeClinVarPMID:28492532
Object Symbol
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Original Reference(s)
Otud7bRatWeight Loss  ISOOTUD7B (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:36639017

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Original Reference(s)
Otud7bRat(1->4)-beta-D-glucan multiple interactionsISOOtud7b (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of OTUD7B mRNACTDPMID:36331819
Otud7bRat1,2-dimethylhydrazine multiple interactionsEXP 6480464[APC protein affects the susceptibility to 1 and 2-Dimethylhydrazine] which results in increased expression of OTUD7B mRNACTDPMID:27840820
Otud7bRat1,2-dimethylhydrazine decreases expressionISOOtud7b (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of OTUD7B mRNACTDPMID:22206623
Otud7bRat17beta-estradiol increases expressionISOOTUD7B (Homo sapiens)6480464Estradiol results in increased expression of OTUD7B mRNACTDPMID:23019147
Otud7bRat17beta-hydroxy-5alpha-androstan-3-one increases expressionISOOTUD7B (Homo sapiens)6480464Dihydrotestosterone results in increased expression of OTUD7B mRNACTDPMID:29581250
Otud7bRat2,2',4,4'-Tetrabromodiphenyl ether increases expressionEXP 64804642 more ...CTDPMID:27291303
Otud7bRat2,2',5,5'-tetrachlorobiphenyl decreases expressionEXP 64804642 more ...CTDPMID:23829299
Otud7bRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOOtud7b (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of OTUD7B mRNACTDPMID:21570461
Otud7bRat3,4-methylenedioxymethamphetamine decreases expressionISOOtud7b (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of OTUD7B mRNACTDPMID:26251327
Otud7bRat4,4'-sulfonyldiphenol increases expressionISOOtud7b (Mus musculus)6480464bisphenol S results in increased expression of OTUD7B mRNACTDPMID:39298647
Otud7bRat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of OTUD7B mRNACTDPMID:24780913 and PMID:30047161
Otud7bRataflatoxin B1 increases expressionISOOtud7b (Mus musculus)6480464Aflatoxin B1 results in increased expression of OTUD7B mRNACTDPMID:19770486
Otud7bRataflatoxin B1 increases methylationISOOTUD7B (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of OTUD7B 3' UTRCTDPMID:30157460
Otud7bRatall-trans-retinoic acid increases expressionEXP 6480464Tretinoin results in increased expression of OTUD7B mRNACTDPMID:20488242
Otud7bRatamitrole decreases expressionEXP 6480464Amitrole results in decreased expression of OTUD7B mRNACTDPMID:30047161
Otud7bRatarsenite(3-) multiple interactionsISOOTUD7B (Homo sapiens)6480464arsenite inhibits the reaction [G3BP1 protein binds to OTUD7B mRNA]CTDPMID:32406909
Otud7bRatatrazine increases expressionISOOTUD7B (Homo sapiens)6480464Atrazine results in increased expression of OTUD7B mRNACTDPMID:22378314
Otud7bRatbenzo[a]pyrene increases expressionISOOtud7b (Mus musculus)6480464Benzo(a)pyrene results in increased expression of OTUD7B mRNACTDPMID:21569818 and PMID:22228805
Otud7bRatbenzo[a]pyrene increases methylationISOOTUD7B (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of OTUD7B promoterCTDPMID:27901495
Otud7bRatbenzo[a]pyrene affects methylationISOOTUD7B (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of OTUD7B 5' UTRCTDPMID:27901495

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Biological Process
1 to 20 of 42 rows

  
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Original Reference(s)
Otud7bRatin utero embryonic development acts_upstream_of_or_withinISOOtud7b (Mus musculus)1624291MGI:5637162 PMID:27996060RGDPMID:27996060
Otud7bRatin utero embryonic development acts_upstream_of_or_withinIEAUniProtKB:B2RUR8 and ensembl:ENSMUSP000000882911600115GO_REF:0000107EnsemblGO_REF:0000107
Otud7bRatmucosal immune response involved_inISOOtud7b (Mus musculus)1624291 PMID:23334419RGDPMID:23334419
Otud7bRatmucosal immune response involved_inISSUniProtKB:B2RUR81600115GO_REF:0000024ParkinsonsUK-UCLGO_REF:0000024
Otud7bRatmucosal immune response involved_inIEAUniProtKB:B2RUR8 and ensembl:ENSMUSP000000882911600115GO_REF:0000107EnsemblGO_REF:0000107
Otud7bRatnegative regulation of canonical NF-kappaB signal transduction involved_inISOOTUD7B (Homo sapiens)1624291 PMID:11463333RGDPMID:11463333
Otud7bRatnegative regulation of canonical NF-kappaB signal transduction involved_inIEAUniProtKB:B2RUR8 and ensembl:ENSMUSP000000882911600115GO_REF:0000107EnsemblGO_REF:0000107
Otud7bRatnegative regulation of canonical NF-kappaB signal transduction involved_inISSUniProtKB:B2RUR81600115GO_REF:0000024ParkinsonsUK-UCLGO_REF:0000024
Otud7bRatnegative regulation of canonical NF-kappaB signal transduction involved_inISOOtud7b (Mus musculus)1624291 PMID:23334419RGDPMID:23334419
Otud7bRatnegative regulation of canonical NF-kappaB signal transduction involved_inIBAMGI:2654703 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Otud7bRatnegative regulation of canonical NF-kappaB signal transduction involved_inIEAUniProtKB:Q6GQQ9 and ensembl:ENSP000004627291600115GO_REF:0000107EnsemblGO_REF:0000107
Otud7bRatnegative regulation of interleukin-8 production acts_upstream_ofIEAUniProtKB:Q6GQQ9 and ensembl:ENSP000004627291600115GO_REF:0000107EnsemblGO_REF:0000107
Otud7bRatnegative regulation of interleukin-8 production acts_upstream_ofISSUniProtKB:Q6GQQ91600115GO_REF:0000024ParkinsonsUK-UCLGO_REF:0000024
Otud7bRatnegative regulation of interleukin-8 production acts_upstream_ofISOOTUD7B (Homo sapiens)1624291 PMID:21097510RGDPMID:21097510
Otud7bRatnegative regulation of protein localization to nucleus involved_inISOOTUD7B (Homo sapiens)1624291 PMID:21097510RGDPMID:21097510
Otud7bRatnegative regulation of protein localization to nucleus involved_inIEAUniProtKB:Q6GQQ9 and ensembl:ENSP000004627291600115GO_REF:0000107EnsemblGO_REF:0000107
Otud7bRatnegative regulation of protein localization to nucleus involved_inISSUniProtKB:Q6GQQ91600115GO_REF:0000024ParkinsonsUK-UCLGO_REF:0000024
Otud7bRatnegative regulation of TORC1 signaling involved_inISOOTUD7B (Homo sapiens)1624291 PMID:28489822RGDPMID:28489822
Otud7bRatnegative regulation of TORC1 signaling involved_inIEAUniProtKB:Q6GQQ9 and ensembl:ENSP000004627291600115GO_REF:0000107EnsemblGO_REF:0000107
Otud7bRatnegative regulation of transcription by RNA polymerase II involved_inISOOTUD7B (Homo sapiens)1624291 PMID:21097510RGDPMID:21097510
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Cellular Component
1 to 14 of 14 rows

  
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Original Reference(s)
Otud7bRatcytoplasm located_inISOOtud7b (Mus musculus)1624291 PMID:12682062RGDPMID:12682062
Otud7bRatcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Otud7bRatcytoplasm located_inIEAUniProtKB:B2RUR8 and ensembl:ENSMUSP000000882911600115GO_REF:0000107EnsemblGO_REF:0000107
Otud7bRatcytoplasm located_inIEAARBA:ARBA000269711600115GO_REF:0000117UniProtGO_REF:0000117
Otud7bRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Otud7bRatcytoplasm is_active_inIBAMGI:1196377 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Otud7bRatcytoplasm located_inIEAUniProtKB:Q6GQQ9 and ensembl:ENSP000004627291600115GO_REF:0000107EnsemblGO_REF:0000107
Otud7bRatcytoplasm located_inISOOTUD7B (Homo sapiens)1624291 PMID:11463333RGDPMID:11463333
Otud7bRatnucleus located_inISOOTUD7B (Homo sapiens)1624291 PMID:11463333RGDPMID:11463333
Otud7bRatnucleus located_inISSUniProtKB:Q6GQQ91600115GO_REF:0000024ParkinsonsUK-UCLGO_REF:0000024
Otud7bRatnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Otud7bRatnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Otud7bRatnucleus is_active_inIBAPANTHER:PTN001001090 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Otud7bRatnucleus located_inIEAUniProtKB:Q6GQQ9 and ensembl:ENSP000004627291600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function
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Original Reference(s)
Otud7bRatcysteine-type deubiquitinase activity enablesISOOTUD7B (Homo sapiens)1624291 PMID:23827681 and PMID:28489822RGDPMID:23827681 and PMID:28489822
Otud7bRatcysteine-type deubiquitinase activity enablesISSUniProtKB:Q6GQQ91600115GO_REF:0000024ParkinsonsUK-UCLGO_REF:0000024
Otud7bRatcysteine-type deubiquitinase activity enablesIEAUniProtKB:Q6GQQ9 and ensembl:ENSP000004627291600115GO_REF:0000107EnsemblGO_REF:0000107
Otud7bRatcysteine-type deubiquitinase activity enablesIEAUniProtKB:B2RUR8 and ensembl:ENSMUSP000000882911600115GO_REF:0000107EnsemblGO_REF:0000107
Otud7bRatcysteine-type deubiquitinase activity enablesISOOtud7b (Mus musculus)1624291 PMID:12682062 and PMID:23334419RGDPMID:12682062 and PMID:23334419
Otud7bRatcysteine-type deubiquitinase activity enablesIBAMGI:2654703 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Otud7bRatcysteine-type peptidase activity enablesIEAUniProtKB:B2RUR8 and ensembl:ENSMUSP000000882911600115GO_REF:0000107EnsemblGO_REF:0000107
Otud7bRatcysteine-type peptidase activity enablesIEAUniProtKB-KW:KW-07881600115GO_REF:0000043UniProtGO_REF:0000043
Otud7bRatcysteine-type peptidase activity enablesISSUniProtKB:B2RUR81600115GO_REF:0000024ParkinsonsUK-UCLGO_REF:0000024
Otud7bRatcysteine-type peptidase activity enablesISOOtud7b (Mus musculus)1624291 PMID:23334419RGDPMID:23334419
Otud7bRatDNA binding enablesIEAInterPro:IPR0026531600115GO_REF:0000002InterProGO_REF:0000002
Otud7bRathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Otud7bRatK48-linked deubiquitinase activity enablesISOOTUD7B (Homo sapiens)1624291 PMID:21097510RGDPMID:21097510
Otud7bRatK48-linked deubiquitinase activity enablesIEAUniProtKB:Q6GQQ9 and ensembl:ENSP000004627291600115GO_REF:0000107EnsemblGO_REF:0000107
Otud7bRatK63-linked polyubiquitin modification-dependent protein binding enablesISOOtud7b (Mus musculus)1624291 PMID:18281465RGDPMID:18281465
Otud7bRatK63-linked polyubiquitin modification-dependent protein binding enablesIEAUniProtKB:B2RUR8 and ensembl:ENSMUSP000000882911600115GO_REF:0000107EnsemblGO_REF:0000107
Otud7bRatK63-linked polyubiquitin modification-dependent protein binding enablesISSUniProtKB:B2RUR81600115GO_REF:0000024ParkinsonsUK-UCLGO_REF:0000024
Otud7bRatK63-linked polyubiquitin modification-dependent protein binding enablesIBAMGI:2654703 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Otud7bRatmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Otud7bRatprotein binding enablesISOOTUD7B (Homo sapiens) and UniProtKB:Q6GQQ9-21624291UniProtKB:A0A6Q8PF08 more ...RGDPMID:32814053
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#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:11463333   PMID:12682062   PMID:16778019   PMID:18281465   PMID:20622874   PMID:21097510   PMID:23334419   PMID:23564640   PMID:23827681   PMID:27996060   PMID:34324860   PMID:35523269  
PMID:38084712  



Otud7b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82186,350,811 - 186,411,461 (+)NCBIGRCr8
mRatBN7.22183,661,955 - 183,722,584 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2183,662,163 - 183,718,674 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2191,325,797 - 191,384,171 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02189,130,056 - 189,188,470 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02183,958,342 - 184,016,709 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02198,231,353 - 198,302,220 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2198,231,291 - 198,300,201 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02217,720,895 - 217,789,205 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42190,905,522 - 190,964,454 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12190,868,275 - 190,938,314 (+)NCBI
Celera2176,190,012 - 176,247,856 (+)NCBICelera
Cytogenetic Map2q34NCBI
OTUD7B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381149,937,812 - 150,067,653 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1149,937,812 - 150,010,726 (-)EnsemblGRCh38hg38GRCh38
GRCh371149,909,705 - 149,982,675 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361148,178,855 - 148,249,310 (-)NCBINCBI36Build 36hg18NCBI36
Build 341146,728,409 - 146,795,602NCBI
Celera1123,028,202 - 123,098,656 (-)NCBICelera
Cytogenetic Map1q21.2NCBI
HuRef1121,292,712 - 121,362,691 (-)NCBIHuRef
CHM1_11151,308,456 - 151,378,863 (-)NCBICHM1_1
T2T-CHM13v2.01149,062,296 - 149,192,273 (-)NCBIT2T-CHM13v2.0
Otud7b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39396,011,759 - 96,068,446 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl396,011,839 - 96,068,446 (+)EnsemblGRCm39 Ensembl
GRCm38396,104,504 - 96,161,129 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl396,104,527 - 96,161,129 (+)EnsemblGRCm38mm10GRCm38
MGSCv37395,908,450 - 95,965,052 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36396,189,932 - 96,246,534 (+)NCBIMGSCv36mm8
Celera397,540,463 - 97,597,279 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map341.65NCBI
Otud7b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955413751,546 - 812,605 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955413758,098 - 812,605 (+)NCBIChiLan1.0ChiLan1.0
OTUD7B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2199,828,379 - 99,901,338 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1199,583,331 - 99,653,002 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01125,282,599 - 125,355,441 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11128,941,260 - 129,005,678 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1128,944,782 - 128,976,474 (-)Ensemblpanpan1.1panPan2
OTUD7B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11759,225,640 - 59,280,875 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1759,229,362 - 59,280,934 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1758,672,817 - 58,728,223 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01760,221,922 - 60,277,210 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1760,221,941 - 60,276,960 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11759,071,375 - 59,126,610 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01759,155,099 - 59,210,354 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01759,882,202 - 59,937,666 (-)NCBIUU_Cfam_GSD_1.0
Otud7b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505821,248,716 - 21,350,025 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936580278,257 - 338,526 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936580278,263 - 300,278 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OTUD7B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl499,054,426 - 99,114,162 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1499,054,426 - 99,111,649 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24108,609,708 - 108,632,906 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OTUD7B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603813,235,718 - 13,366,144 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Otud7b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477217,721,218 - 17,787,299 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477217,717,178 - 17,776,940 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Otud7b
267 total Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
2 198284049 198284050 C G snv SR/JrHsd (RGD) View more Information

Predicted Target Of
Summary Value
Count of predictions:396
Count of miRNA genes:205
Interacting mature miRNAs:276
Transcripts:ENSRNOT00000046739
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 70 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2122609194206936711Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat

1 to 10 of 70 rows
D2Rat134  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22183,719,124 - 183,719,262 (+)MAPPERmRatBN7.2
Rnor_6.02198,298,764 - 198,298,901NCBIRnor6.0
Rnor_5.02217,785,747 - 217,785,884UniSTSRnor5.0
RGSC_v3.42190,963,017 - 190,963,154UniSTSRGSC3.4
Celera2176,246,419 - 176,246,556UniSTS
RH 3.4 Map21223.0UniSTS
RH 3.4 Map21223.0RGD
RH 2.0 Map2898.3RGD
FHH x ACI Map278.8099RGD
Cytogenetic Map2q34UniSTS
AI462125  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22183,718,362 - 183,718,466 (+)MAPPERmRatBN7.2
Rnor_6.02198,298,002 - 198,298,105NCBIRnor6.0
Rnor_5.02217,784,985 - 217,785,088UniSTSRnor5.0
RGSC_v3.42190,962,255 - 190,962,358UniSTSRGSC3.4
Celera2176,245,657 - 176,245,760UniSTS
Cytogenetic Map2q34UniSTS
RH142787  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22183,718,278 - 183,718,415 (+)MAPPERmRatBN7.2
Rnor_6.02198,297,918 - 198,298,054NCBIRnor6.0
Rnor_5.02217,784,901 - 217,785,037UniSTSRnor5.0
RGSC_v3.42190,962,171 - 190,962,307UniSTSRGSC3.4
Celera2176,245,573 - 176,245,709UniSTS
RH 3.4 Map21222.7UniSTS
Cytogenetic Map2q34UniSTS
RH141601  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22183,720,158 - 183,720,375 (+)MAPPERmRatBN7.2
Rnor_6.02198,299,797 - 198,300,013NCBIRnor6.0
Rnor_5.02217,786,780 - 217,786,996UniSTSRnor5.0
RGSC_v3.42190,964,050 - 190,964,266UniSTSRGSC3.4
Celera2176,247,452 - 176,247,668UniSTS
RH 3.4 Map21221.5UniSTS
Cytogenetic Map2q34UniSTS
BE117295  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22183,687,097 - 183,687,296 (+)MAPPERmRatBN7.2
Rnor_6.02198,267,069 - 198,267,267NCBIRnor6.0
Rnor_5.02217,754,356 - 217,754,554UniSTSRnor5.0
RGSC_v3.42190,930,693 - 190,930,891UniSTSRGSC3.4
Celera2176,214,936 - 176,215,134UniSTS
RH 3.4 Map21222.7UniSTS
Cytogenetic Map2q34UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000046739   ⟹   ENSRNOP00000039488
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2198,231,353 - 198,300,201 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078288   ⟹   ENSRNOP00000073488
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2183,662,163 - 183,718,674 (+)Ensembl
Rnor_6.0 Ensembl2198,231,291 - 198,297,323 (+)Ensembl
RefSeq Acc Id: NM_001107697   ⟹   NP_001101167
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82186,350,844 - 186,409,440 (+)NCBI
mRatBN7.22183,661,955 - 183,720,563 (+)NCBI
Rnor_6.02198,231,353 - 198,300,201 (+)NCBI
Rnor_5.02217,720,895 - 217,789,205 (+)NCBI
RGSC_v3.42190,905,522 - 190,964,454 (+)RGD
Celera2176,190,012 - 176,247,856 (+)RGD
Sequence:
RefSeq Acc Id: XM_006232957   ⟹   XP_006233019
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82186,350,963 - 186,411,461 (+)NCBI
mRatBN7.22183,662,106 - 183,722,584 (+)NCBI
Rnor_6.02198,231,552 - 198,302,220 (+)NCBI
Rnor_5.02217,720,895 - 217,789,205 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063281880   ⟹   XP_063137950
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82186,350,963 - 186,411,461 (+)NCBI
RefSeq Acc Id: XM_063281881   ⟹   XP_063137951
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82186,376,453 - 186,411,461 (+)NCBI
RefSeq Acc Id: XM_063281882   ⟹   XP_063137952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82186,354,942 - 186,411,461 (+)NCBI
RefSeq Acc Id: XM_063281883   ⟹   XP_063137953
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82186,350,811 - 186,411,461 (+)NCBI
RefSeq Acc Id: XM_063281884   ⟹   XP_063137954
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82186,389,133 - 186,411,461 (+)NCBI
RefSeq Acc Id: XM_063281885   ⟹   XP_063137955
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82186,350,816 - 186,411,461 (+)NCBI
RefSeq Acc Id: XM_063281886   ⟹   XP_063137956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82186,389,127 - 186,411,461 (+)NCBI
1 to 5 of 11 rows
1 to 5 of 11 rows
RefSeq Acc Id: NP_001101167   ⟸   NM_001107697
- UniProtKB: A6K349 (UniProtKB/TrEMBL),   A0A0G2K5N0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233019   ⟸   XM_006232957
- Peptide Label: isoform X1
- UniProtKB: A6K349 (UniProtKB/TrEMBL),   A0A0G2K5N0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073488   ⟸   ENSRNOT00000078288
Ensembl Acc Id: ENSRNOP00000039488   ⟸   ENSRNOT00000046739
RefSeq Acc Id: XP_063137953   ⟸   XM_063281883
- Peptide Label: isoform X1
- UniProtKB: A6K349 (UniProtKB/TrEMBL),   A0A0G2K5N0 (UniProtKB/TrEMBL)
A20-type   OTU

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZH40-F1-model_v2 AlphaFold D3ZH40 1-841 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13691565
Promoter ID:EPDNEW_R2089
Type:initiation region
Name:Otud7b_1
Description:OTU deubiquitinase 7B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02198,231,372 - 198,231,432EPDNEW


1 to 27 of 27 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-52054 BioCyc
Ensembl Genes ENSRNOG00000042068 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078288 ENTREZGENE
  ENSRNOT00000078288.2 UniProtKB/TrEMBL
  ENSRNOT00000164143 ENTREZGENE
Gene3D-CATH 1.20.5.4770 UniProtKB/TrEMBL
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/TrEMBL
InterPro OTU UniProtKB/TrEMBL
  OTU_Deubiquitinase UniProtKB/TrEMBL
  UBA_8 UniProtKB/TrEMBL
  Znf_A20 UniProtKB/TrEMBL
KEGG Report rno:310677 UniProtKB/TrEMBL
NCBI Gene 310677 ENTREZGENE
PANTHER OTU DOMAIN-CONTAINING PROTEIN 7B UniProtKB/TrEMBL
  UBIQUITIN THIOESTERASE UniProtKB/TrEMBL
Pfam OTU UniProtKB/TrEMBL
  UBA_8 UniProtKB/TrEMBL
  zf-A20 UniProtKB/TrEMBL
PhenoGen Otud7b PhenoGen
PROSITE OTU UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
  ZF_A20 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042068 RatGTEx
SMART ZnF_A20 UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
UniProt A0A0G2K5N0 ENTREZGENE, UniProtKB/TrEMBL
  A6K349 ENTREZGENE, UniProtKB/TrEMBL
1 to 27 of 27 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-13 Otud7b  OTU deubiquitinase 7B  Otud7b  OTU domain containing 7B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-26 Otud7b  OTU domain containing 7B  RGD1308111_predicted  similar to zinc finger protein Cezanne; cellular zinc finger anti-NF-kappaB Cezanne (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1308111_predicted  similar to zinc finger protein Cezanne; cellular zinc finger anti-NF-kappaB Cezanne (predicted)  LOC310677_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC310677_predicted  similar to zinc finger protein Cezanne; cellular zinc finger anti-NF-kappaB Cezanne (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL