Symbol:
Otub2
Name:
OTU deubiquitinase, ubiquitin aldehyde binding 2
RGD ID:
1306688
Description:
Predicted to enable cysteine-type deubiquitinase activity and ubiquitin binding activity. Predicted to be involved in protein K11-linked deubiquitination; protein K48-linked deubiquitination; and protein K63-linked deubiquitination. Orthologous to human OTUB2 (OTU deubiquitinase, ubiquitin aldehyde binding 2); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
LOC314405; OTU domain, ubiquitin aldehyde binding 2; ubiquitin thioesterase OTUB2
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
OTUB2 (OTU deubiquitinase, ubiquitin aldehyde binding 2) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Otub2 (OTU domain, ubiquitin aldehyde binding 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):
Otub2 (OTU deubiquitinase, ubiquitin aldehyde binding 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
OTUB2 (OTU deubiquitinase, ubiquitin aldehyde binding 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
OTUB2 (OTU deubiquitinase, ubiquitin aldehyde binding 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Otub2 (OTU deubiquitinase, ubiquitin aldehyde binding 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
OTUB2 (OTU deubiquitinase, ubiquitin aldehyde binding 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
OTUB2 (OTU deubiquitinase, ubiquitin aldehyde binding 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Otub2 (OTU deubiquitinase, ubiquitin aldehyde binding 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
EEF1AKMT2 (EEF1A lysine methyltransferase 2) HGNC
OMA
Alliance orthologs 3
Homo sapiens (human):
OTUB2 (OTU deubiquitinase, ubiquitin aldehyde binding 2)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Mus musculus (house mouse):
Otub2 (OTU domain, ubiquitin aldehyde binding 2)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Caenorhabditis elegans (roundworm):
otub-1
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|SonicParanoid)
Drosophila melanogaster (fruit fly):
CG4968
Alliance
DIOPT (Hieranoid|OrthoFinder|PANTHER|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):
otub2
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoInspector|PANTHER|PhylomeDB)
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 6 128,309,863 - 128,328,444 (+) NCBI GRCr8 mRatBN7.2 6 122,545,067 - 122,563,657 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 6 122,545,061 - 122,563,644 (+) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 6 122,685,956 - 122,704,500 (+) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 6 122,981,218 - 122,999,762 (+) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 6 122,315,785 - 122,334,308 (+) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 6 127,282,445 - 127,301,086 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 6 127,282,466 - 127,301,083 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 6 136,503,029 - 136,521,616 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 6 127,679,755 - 127,698,318 (+) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 6 127,683,523 - 127,700,562 (+) NCBI Celera 6 120,025,797 - 120,044,342 (+) NCBI Celera Cytogenetic Map 6 q32 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Only show annotations with direct experimental evidence (0 objects hidden)
Otub2 Rat 1-naphthyl isothiocyanate decreases expression EXP 6480464 1-Naphthylisothiocyanate results in decreased expression of OTUB2 mRNA CTD PMID:25380136 Otub2 Rat 17alpha-ethynylestradiol affects expression ISO Otub2 (Mus musculus) 6480464 Ethinyl Estradiol affects the expression of OTUB2 mRNA CTD PMID:17555576 Otub2 Rat 17alpha-ethynylestradiol multiple interactions ISO Otub2 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of OTUB2 mRNA CTD PMID:17942748 Otub2 Rat 17alpha-ethynylestradiol increases expression ISO Otub2 (Mus musculus) 6480464 Ethinyl Estradiol results in increased expression of OTUB2 mRNA CTD PMID:17942748 Otub2 Rat 17beta-estradiol multiple interactions ISO OTUB2 (Homo sapiens) 6480464 [Estradiol co-treated with TGFB1 protein] results in increased expression of OTUB2 mRNA CTD PMID:30165855 Otub2 Rat 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of OTUB2 mRNA CTD PMID:32145629 Otub2 Rat 2,3',4,4',5-Pentachlorobiphenyl increases expression ISO Otub2 (Mus musculus) 6480464 2 more ... CTD PMID:31388691 Otub2 Rat 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Otub2 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of OTUB2 mRNA and Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to OTUB2 promoter] CTD PMID:17942748 and PMID:19654925 Otub2 Rat 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO OTUB2 (Homo sapiens) 6480464 [Tetrachlorodibenzodioxin co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] results in decreased expression of OTUB2 mRNA CTD PMID:29704546 Otub2 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO OTUB2 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in increased expression of OTUB2 mRNA CTD PMID:20106945 more ... Otub2 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of OTUB2 mRNA CTD PMID:21215274 and PMID:33387578 Otub2 Rat 2-hydroxypropanoic acid decreases expression ISO OTUB2 (Homo sapiens) 6480464 Lactic Acid results in decreased expression of OTUB2 mRNA CTD PMID:30851411 Otub2 Rat 3,3',5,5'-tetrabromobisphenol A increases expression ISO Otub2 (Mus musculus) 6480464 tetrabromobisphenol A results in increased expression of OTUB2 mRNA CTD PMID:25172293 Otub2 Rat 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO OTUB2 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of OTUB2 mRNA CTD PMID:28628672 Otub2 Rat 3-methylcholanthrene multiple interactions ISO OTUB2 (Homo sapiens) 6480464 Methylcholanthrene promotes the reaction [AHR protein binds to OTUB2 promoter] CTD PMID:20348232 Otub2 Rat 4,4'-diaminodiphenylmethane decreases expression EXP 6480464 4 and 4'-diaminodiphenylmethane results in decreased expression of OTUB2 mRNA CTD PMID:25380136 Otub2 Rat acetamide decreases expression EXP 6480464 acetamide results in decreased expression of OTUB2 mRNA CTD PMID:31881176 Otub2 Rat aflatoxin B1 decreases expression ISO Otub2 (Mus musculus) 6480464 Aflatoxin B1 results in decreased expression of OTUB2 mRNA CTD PMID:19770486 Otub2 Rat aflatoxin B1 increases expression ISO OTUB2 (Homo sapiens) 6480464 Aflatoxin B1 results in increased expression of OTUB2 mRNA CTD PMID:21641981 Otub2 Rat Aflatoxin B2 alpha increases methylation ISO OTUB2 (Homo sapiens) 6480464 aflatoxin B2 results in increased methylation of OTUB2 intron CTD PMID:30157460 Otub2 Rat arsane multiple interactions ISO OTUB2 (Homo sapiens) 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of OTUB2 mRNA CTD PMID:32525701 Otub2 Rat arsenic atom multiple interactions ISO OTUB2 (Homo sapiens) 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of OTUB2 mRNA CTD PMID:32525701 Otub2 Rat benzo[a]pyrene increases expression ISO OTUB2 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased expression of OTUB2 mRNA CTD PMID:20106945 and PMID:21632981 Otub2 Rat benzo[a]pyrene affects methylation ISO OTUB2 (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of OTUB2 intron CTD PMID:30157460 Otub2 Rat benzo[a]pyrene increases methylation ISO OTUB2 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of OTUB2 promoter CTD PMID:27901495 Otub2 Rat benzo[a]pyrene increases methylation ISO Otub2 (Mus musculus) 6480464 Benzo(a)pyrene results in increased methylation of OTUB2 5' UTR more ... CTD PMID:27901495 Otub2 Rat benzo[e]pyrene increases methylation ISO OTUB2 (Homo sapiens) 6480464 benzo(e)pyrene results in increased methylation of OTUB2 intron CTD PMID:30157460 Otub2 Rat bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Testosterone] results in increased expression of OTUB2 mRNA CTD PMID:26496021 Otub2 Rat bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of OTUB2 mRNA CTD PMID:32145629 Otub2 Rat bisphenol A decreases expression ISO OTUB2 (Homo sapiens) 6480464 bisphenol A analog results in decreased expression of OTUB2 mRNA CTD PMID:32387340 Otub2 Rat bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of OTUB2 gene CTD PMID:28505145 Otub2 Rat bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of OTUB2 mRNA CTD PMID:25181051 Otub2 Rat bisphenol F multiple interactions ISO OTUB2 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of OTUB2 mRNA CTD PMID:28628672 Otub2 Rat casticin decreases expression ISO Otub2 (Mus musculus) 6480464 casticin results in decreased expression of OTUB2 mRNA CTD PMID:28444820 Otub2 Rat CGP 52608 multiple interactions ISO OTUB2 (Homo sapiens) 6480464 CGP 52608 promotes the reaction [RORA protein binds to OTUB2 gene] CTD PMID:28238834 Otub2 Rat chlorpyrifos increases expression ISO Otub2 (Mus musculus) 6480464 Chlorpyrifos results in increased expression of OTUB2 mRNA CTD PMID:37019170 Otub2 Rat choline multiple interactions ISO Otub2 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of OTUB2 gene CTD PMID:20938992 Otub2 Rat cisplatin multiple interactions ISO OTUB2 (Homo sapiens) 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of OTUB2 mRNA CTD PMID:27392435 Otub2 Rat cisplatin increases expression ISO OTUB2 (Homo sapiens) 6480464 Cisplatin results in increased expression of OTUB2 mRNA CTD PMID:27392435 Otub2 Rat crocidolite asbestos increases expression ISO OTUB2 (Homo sapiens) 6480464 Asbestos and Crocidolite results in increased expression of OTUB2 mRNA CTD PMID:25351596 Otub2 Rat crocidolite asbestos increases expression ISO Otub2 (Mus musculus) 6480464 Asbestos and Crocidolite results in increased expression of OTUB2 mRNA CTD PMID:29279043 Otub2 Rat Cuprizon decreases expression EXP 6480464 Cuprizone results in decreased expression of OTUB2 mRNA CTD PMID:26577399 Otub2 Rat cypermethrin increases expression ISO Otub2 (Mus musculus) 6480464 cypermethrin results in increased expression of OTUB2 mRNA CTD PMID:29020013 Otub2 Rat dexamethasone multiple interactions ISO OTUB2 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of OTUB2 mRNA CTD PMID:28628672 Otub2 Rat dibutyl phthalate decreases expression ISO Otub2 (Mus musculus) 6480464 Dibutyl Phthalate results in decreased expression of OTUB2 mRNA CTD PMID:21266533 Otub2 Rat dorsomorphin multiple interactions ISO OTUB2 (Homo sapiens) 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 Otub2 Rat folic acid multiple interactions ISO Otub2 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of OTUB2 gene CTD PMID:20938992 Otub2 Rat genistein increases expression ISO OTUB2 (Homo sapiens) 6480464 Genistein results in increased expression of OTUB2 mRNA CTD PMID:20884965 Otub2 Rat indometacin multiple interactions ISO OTUB2 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of OTUB2 mRNA CTD PMID:28628672 Otub2 Rat isotretinoin decreases expression ISO OTUB2 (Homo sapiens) 6480464 Isotretinoin results in decreased expression of OTUB2 mRNA CTD PMID:20436886 Otub2 Rat L-methionine multiple interactions ISO Otub2 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of OTUB2 gene CTD PMID:20938992 Otub2 Rat lucanthone increases expression ISO OTUB2 (Homo sapiens) 6480464 Lucanthone results in increased expression of OTUB2 mRNA CTD PMID:21148553 Otub2 Rat metformin increases expression EXP 6480464 Metformin results in increased expression of OTUB2 mRNA CTD PMID:31324951 Otub2 Rat methapyrilene increases methylation ISO OTUB2 (Homo sapiens) 6480464 Methapyrilene results in increased methylation of OTUB2 intron CTD PMID:30157460 Otub2 Rat N-methyl-4-phenylpyridinium increases methylation EXP 6480464 1-Methyl-4-phenylpyridinium results in increased methylation of OTUB2 gene CTD PMID:28801915 Otub2 Rat N-methyl-4-phenylpyridinium increases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in increased expression of OTUB2 mRNA CTD PMID:28801915 Otub2 Rat N-nitrosodimethylamine decreases expression EXP 6480464 Dimethylnitrosamine results in decreased expression of OTUB2 mRNA CTD PMID:25380136 Otub2 Rat oxaliplatin multiple interactions EXP 6480464 [Oxaliplatin co-treated with Topotecan] results in decreased expression of OTUB2 mRNA and [Topotecan co-treated with Oxaliplatin] results in decreased expression of OTUB2 mRNA CTD PMID:25729387 Otub2 Rat oxaliplatin decreases expression EXP 6480464 oxaliplatin results in decreased expression of OTUB2 mRNA CTD PMID:25729387 Otub2 Rat paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of OTUB2 mRNA CTD PMID:32479839 Otub2 Rat paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of OTUB2 mRNA CTD PMID:33387578 Otub2 Rat pirinixic acid decreases expression ISO Otub2 (Mus musculus) 6480464 pirinixic acid results in decreased expression of OTUB2 mRNA CTD PMID:23811191 Otub2 Rat quercetin increases expression ISO OTUB2 (Homo sapiens) 6480464 Quercetin results in increased expression of OTUB2 mRNA CTD PMID:21632981 Otub2 Rat rac-lactic acid decreases expression ISO OTUB2 (Homo sapiens) 6480464 Lactic Acid results in decreased expression of OTUB2 mRNA CTD PMID:30851411 Otub2 Rat raloxifene multiple interactions ISO OTUB2 (Homo sapiens) 6480464 [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of OTUB2 mRNA CTD PMID:19059307 Otub2 Rat raloxifene decreases expression ISO Otub2 (Mus musculus) 6480464 Raloxifene Hydrochloride results in decreased expression of OTUB2 mRNA CTD PMID:33269387 Otub2 Rat rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of OTUB2 mRNA CTD PMID:28374803 Otub2 Rat SB 431542 multiple interactions ISO OTUB2 (Homo sapiens) 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 Otub2 Rat silicon dioxide increases expression ISO OTUB2 (Homo sapiens) 6480464 Silicon Dioxide analog results in increased expression of OTUB2 mRNA and Silicon Dioxide results in increased expression of OTUB2 mRNA CTD PMID:25351596 and PMID:25895662 Otub2 Rat sodium arsenate multiple interactions ISO OTUB2 (Homo sapiens) 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of OTUB2 mRNA CTD PMID:32525701 Otub2 Rat sodium arsenite decreases expression ISO Otub2 (Mus musculus) 6480464 sodium arsenite results in decreased expression of OTUB2 mRNA CTD PMID:37682722 Otub2 Rat sodium dichromate decreases expression EXP 6480464 sodium bichromate results in decreased expression of OTUB2 mRNA CTD PMID:25993096 Otub2 Rat Soman decreases expression EXP 6480464 Soman results in decreased expression of OTUB2 mRNA CTD PMID:19281266 Otub2 Rat tamoxifen multiple interactions ISO OTUB2 (Homo sapiens) 6480464 [Tamoxifen co-treated with ESR2 protein] results in decreased expression of OTUB2 mRNA CTD PMID:19059307 Otub2 Rat tamoxifen affects expression ISO Otub2 (Mus musculus) 6480464 Tamoxifen affects the expression of OTUB2 mRNA CTD PMID:17555576 Otub2 Rat temozolomide decreases expression ISO OTUB2 (Homo sapiens) 6480464 Temozolomide results in decreased expression of OTUB2 mRNA CTD PMID:31758290 Otub2 Rat testosterone multiple interactions EXP 6480464 [bisphenol A co-treated with Testosterone] results in increased expression of OTUB2 mRNA CTD PMID:26496021 Otub2 Rat thimerosal decreases expression ISO OTUB2 (Homo sapiens) 6480464 Thimerosal results in decreased expression of OTUB2 mRNA CTD PMID:27188386 Otub2 Rat thioacetamide decreases expression EXP 6480464 Thioacetamide results in decreased expression of OTUB2 mRNA CTD PMID:23411599 and PMID:34492290 Otub2 Rat titanium dioxide decreases expression ISO Otub2 (Mus musculus) 6480464 titanium dioxide results in decreased expression of OTUB2 mRNA CTD PMID:29264374 Otub2 Rat titanium dioxide increases methylation ISO Otub2 (Mus musculus) 6480464 titanium dioxide results in increased methylation of OTUB2 gene CTD PMID:35295148 Otub2 Rat topotecan decreases expression EXP 6480464 Topotecan results in decreased expression of OTUB2 mRNA CTD PMID:25729387 Otub2 Rat topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of OTUB2 mRNA and [Topotecan co-treated with oxaliplatin] results in decreased expression of OTUB2 mRNA CTD PMID:25729387 Otub2 Rat trichloroethene increases expression EXP 6480464 Trichloroethylene results in increased expression of OTUB2 mRNA CTD PMID:33387578 Otub2 Rat trimellitic anhydride increases expression ISO Otub2 (Mus musculus) 6480464 trimellitic anhydride results in increased expression of OTUB2 mRNA CTD PMID:19042947 Otub2 Rat triphenyl phosphate increases expression EXP 6480464 triphenyl phosphate results in increased expression of OTUB2 mRNA CTD PMID:30589522 Otub2 Rat triptonide decreases expression ISO Otub2 (Mus musculus) 6480464 triptonide results in decreased expression of OTUB2 mRNA CTD PMID:33045310 Otub2 Rat urethane decreases expression ISO OTUB2 (Homo sapiens) 6480464 Urethane results in decreased expression of OTUB2 mRNA CTD PMID:28818685 Otub2 Rat valdecoxib decreases expression EXP 6480464 valdecoxib results in decreased expression of OTUB2 mRNA CTD PMID:24136188 Otub2 Rat valproic acid increases methylation ISO OTUB2 (Homo sapiens) 6480464 Valproic Acid results in increased methylation of OTUB2 gene CTD PMID:29154799 Otub2 Rat valproic acid decreases expression ISO OTUB2 (Homo sapiens) 6480464 Valproic Acid results in decreased expression of OTUB2 mRNA CTD PMID:23179753 and PMID:26272509 Otub2 Rat valproic acid multiple interactions ISO OTUB2 (Homo sapiens) 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OTUB2 mRNA CTD PMID:27188386 Otub2 Rat vorinostat multiple interactions ISO OTUB2 (Homo sapiens) 6480464 [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OTUB2 mRNA CTD PMID:27188386
1-naphthyl isothiocyanate (EXP) 17alpha-ethynylestradiol (ISO) 17beta-estradiol (EXP,ISO) 2,3',4,4',5-Pentachlorobiphenyl (ISO) 2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO) 2-hydroxypropanoic acid (ISO) 3,3',5,5'-tetrabromobisphenol A (ISO) 3-isobutyl-1-methyl-7H-xanthine (ISO) 3-methylcholanthrene (ISO) 4,4'-diaminodiphenylmethane (EXP) acetamide (EXP) aflatoxin B1 (ISO) Aflatoxin B2 alpha (ISO) arsane (ISO) arsenic atom (ISO) benzo[a]pyrene (ISO) benzo[e]pyrene (ISO) bisphenol A (EXP,ISO) bisphenol F (ISO) casticin (ISO) CGP 52608 (ISO) chlorpyrifos (ISO) choline (ISO) cisplatin (ISO) crocidolite asbestos (ISO) Cuprizon (EXP) cypermethrin (ISO) dexamethasone (ISO) dibutyl phthalate (ISO) dorsomorphin (ISO) folic acid (ISO) genistein (ISO) indometacin (ISO) isotretinoin (ISO) L-methionine (ISO) lucanthone (ISO) metformin (EXP) methapyrilene (ISO) N-methyl-4-phenylpyridinium (EXP) N-nitrosodimethylamine (EXP) oxaliplatin (EXP) paracetamol (EXP) pirinixic acid (ISO) quercetin (ISO) rac-lactic acid (ISO) raloxifene (ISO) rotenone (EXP) SB 431542 (ISO) silicon dioxide (ISO) sodium arsenate (ISO) sodium arsenite (ISO) sodium dichromate (EXP) Soman (EXP) tamoxifen (ISO) temozolomide (ISO) testosterone (EXP) thimerosal (ISO) thioacetamide (EXP) titanium dioxide (ISO) topotecan (EXP) trichloroethene (EXP) trimellitic anhydride (ISO) triphenyl phosphate (EXP) triptonide (ISO) urethane (ISO) valdecoxib (EXP) valproic acid (ISO) vorinostat (ISO)
Otub2 Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 6 128,309,863 - 128,328,444 (+) NCBI GRCr8 mRatBN7.2 6 122,545,067 - 122,563,657 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 6 122,545,061 - 122,563,644 (+) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 6 122,685,956 - 122,704,500 (+) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 6 122,981,218 - 122,999,762 (+) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 6 122,315,785 - 122,334,308 (+) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 6 127,282,445 - 127,301,086 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 6 127,282,466 - 127,301,083 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 6 136,503,029 - 136,521,616 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 6 127,679,755 - 127,698,318 (+) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 6 127,683,523 - 127,700,562 (+) NCBI Celera 6 120,025,797 - 120,044,342 (+) NCBI Celera Cytogenetic Map 6 q32 NCBI
OTUB2 Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 14 94,026,340 - 94,048,930 (+) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl 14 94,026,340 - 94,048,930 (+) Ensembl GRCh38 hg38 GRCh38 GRCh37 14 94,492,686 - 94,515,276 (+) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 14 93,562,477 - 93,585,029 (+) NCBI NCBI36 Build 36 hg18 NCBI36 Build 34 14 93,562,476 - 93,585,027 NCBI Celera 14 74,546,470 - 74,569,021 (+) NCBI Celera Cytogenetic Map 14 q32.12 NCBI HuRef 14 74,672,717 - 74,695,267 (+) NCBI HuRef CHM1_1 14 94,430,740 - 94,453,290 (+) NCBI CHM1_1 T2T-CHM13v2.0 14 88,253,655 - 88,276,245 (+) NCBI T2T-CHM13v2.0
Otub2 Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 12 103,343,244 - 103,372,609 (+) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 12 103,354,941 - 103,372,609 (+) Ensembl GRCm39 Ensembl GRCm38 12 103,376,894 - 103,406,350 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 12 103,388,682 - 103,406,350 (+) Ensembl GRCm38 mm10 GRCm38 MGSCv37 12 104,615,104 - 104,644,560 (+) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 12 103,789,755 - 103,807,393 (+) NCBI MGSCv36 mm8 Celera 12 104,593,576 - 104,623,107 (+) NCBI Celera Cytogenetic Map 12 E NCBI cM Map 12 52.92 NCBI
Otub2 Chinchilla Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChiLan1.0 Ensembl NW_004955438 16,079,860 - 16,096,686 (+) Ensembl ChiLan1.0 ChiLan1.0 NW_004955438 16,079,859 - 16,096,686 (+) NCBI ChiLan1.0 ChiLan1.0
OTUB2 Bonobo Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl NHGRI_mPanPan1-v2 15 95,183,769 - 95,206,322 (+) NCBI NHGRI_mPanPan1-v2 NHGRI_mPanPan1 14 94,400,278 - 94,424,970 (+) NCBI NHGRI_mPanPan1 Mhudiblu_PPA_v0 14 74,658,535 - 74,681,084 (+) NCBI Mhudiblu_PPA_v0 Mhudiblu_PPA_v0 panPan3 PanPan1.1 14 93,991,913 - 94,015,157 (+) NCBI panpan1.1 PanPan1.1 panPan2 PanPan1.1 Ensembl 14 93,991,913 - 94,015,157 (+) Ensembl panpan1.1 panPan2
OTUB2 Dog Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl CanFam3.1 8 63,094,378 - 63,114,028 (+) NCBI CanFam3.1 CanFam3.1 canFam3 CanFam3.1 CanFam3.1 Ensembl 8 63,095,238 - 63,118,441 (+) Ensembl CanFam3.1 canFam3 CanFam3.1 Dog10K_Boxer_Tasha 8 62,671,269 - 62,687,875 (+) NCBI Dog10K_Boxer_Tasha ROS_Cfam_1.0 8 63,365,723 - 63,384,970 (+) NCBI ROS_Cfam_1.0 ROS_Cfam_1.0 Ensembl 8 63,366,089 - 63,384,501 (+) Ensembl ROS_Cfam_1.0 Ensembl UMICH_Zoey_3.1 8 63,043,280 - 63,059,899 (+) NCBI UMICH_Zoey_3.1 UNSW_CanFamBas_1.0 8 63,094,695 - 63,111,321 (+) NCBI UNSW_CanFamBas_1.0 UU_Cfam_GSD_1.0 8 63,424,888 - 63,441,523 (+) NCBI UU_Cfam_GSD_1.0
Otub2 Squirrel Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl HiC_Itri_2 NW_024408640 11,557,728 - 11,575,942 (-) NCBI HiC_Itri_2 SpeTri2.0 Ensembl NW_004936733 1,891,132 - 1,909,392 (+) Ensembl SpeTri2.0 SpeTri2.0 Ensembl SpeTri2.0 NW_004936733 1,891,198 - 1,913,389 (+) NCBI SpeTri2.0 SpeTri2.0 SpeTri2.0
OTUB2 Pig Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Sscrofa11.1 Ensembl 7 115,304,871 - 115,327,054 (+) Ensembl Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa11.1 7 115,304,809 - 115,326,055 (+) NCBI Sscrofa11.1 Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa10.2 7 122,163,455 - 122,182,349 (+) NCBI Sscrofa10.2 Sscrofa10.2 susScr3
OTUB2 Green Monkey Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChlSab1.1 24 71,783,388 - 71,806,721 (+) NCBI ChlSab1.1 ChlSab1.1 chlSab2 ChlSab1.1 Ensembl 24 71,795,047 - 71,803,732 (+) Ensembl ChlSab1.1 ChlSab1.1 Ensembl chlSab2 Vero_WHO_p1.0 NW_023666053 59,023,310 - 59,046,089 (+) NCBI Vero_WHO_p1.0 Vero_WHO_p1.0
Otub2
.
Predicted Target Of
Count of predictions: 265 Count of miRNA genes: 181 Interacting mature miRNAs: 218 Transcripts: ENSRNOT00000012124 Prediction methods: Miranda, Targetscan Result types: miRGate_prediction
12801411 Schws8 Schwannoma susceptibility QTL 8 nervous system integrity trait (VT:0010566) percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017) 6 94968928 139968928 Rat 1331797 Bp213 Blood pressure QTL 213 3.291 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 6 104085867 128713626 Rat 1331799 Bp211 Blood pressure QTL 211 3.66407 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 6 72202632 130919985 Rat 71111 Iddm8 Insulin dependent diabetes mellitus QTL 8 1.9 0.002 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) 6 105156861 140994061 Rat 1358355 Srcrt4 Stress Responsive Cort QTL 4 6.39 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 6 100364669 140994061 Rat 61329 Eae9 Experimental allergic encephalomyelitis QTL 9 3.7 body mass (VT:0001259) change in body weight (CMO:0002045) 6 122549046 140994061 Rat 2313399 Anxrr28 Anxiety related response QTL 28 aggression-related behavior trait (VT:0015014) tameness/aggressiveness composite score (CMO:0002136) 6 100671796 132340886 Rat 1331725 Bp212 Blood pressure QTL 212 3.52475 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 6 93701310 128713626 Rat 8552796 Vie3 Viral induced encephalitis QTL 3 2.6 brain integrity trait (VT:0010579) encephalitis incidence/prevalence measurement (CMO:0002361) 6 96833997 140994061 Rat 4145118 Mcs26 Mammary carcinoma susceptibility QTL 26 0.0001 mammary gland integrity trait (VT:0010552) post-insult time to mammary tumor formation (CMO:0000345) 6 106752656 132339866 Rat 1581563 Uae33 Urinary albumin excretion QTL 33 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 6 72227641 130729205 Rat 10054138 Gmadr3 Adrenal mass QTL 3 3.68 0.00045 adrenal gland mass (VT:0010420) both adrenal glands wet weight (CMO:0000164) 6 85140138 130140138 Rat 1641917 Colcr5 Colorectal carcinoma resistance QTL 5 3.18 0.0009 intestine integrity trait (VT:0010554) benign colorectal tumor number (CMO:0001795) 6 122549046 137801795 Rat 61414 Pia3 Pristane induced arthritis QTL 3 4.5 joint integrity trait (VT:0010548) post-insult time to onset of experimental arthritis (CMO:0001450) 6 94968928 137848904 Rat 724513 Uae14 Urinary albumin excretion QTL 14 6.5 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 6 85311061 133478515 Rat 2303624 Vencon5 Ventilatory control QTL 5 4.45 respiration trait (VT:0001943) minute ventilation (CMO:0000132) 6 88047916 133047916 Rat 731173 Uae22 Urinary albumin excretion QTL 22 10.1 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 6 65531555 140994061 Rat 10054123 Srcrt6 Stress Responsive Cort QTL 6 2.5 0.0043 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 6 85140138 130140138 Rat 724536 Uae7 Urinary albumin excretion QTL 7 3.5 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) 6 72202632 130729475 Rat 737976 Pia24 Pristane induced arthritis QTL 24 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 6 112636280 140994061 Rat 1298087 Iddm18 Insulin dependent diabetes mellitus QTL 18 0.0001 urine glucose amount (VT:0001758) percentage of study population developing diabetes mellitus during a period of time (CMO:0001114) 6 116506292 130245370 Rat 1581550 Pur8 Proteinuria QTL 8 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) 6 72227641 130729205 Rat 738034 Anxrr5 Anxiety related response QTL 5 5.9 exploratory behavior trait (VT:0010471) percentage of entries into a discrete space in an experimental apparatus (CMO:0000961) 6 84130881 129130881 Rat 2290393 Uae37 Urinary albumin excretion QTL 37 0.0001 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 6 65531555 140994061 Rat 1300076 Glom8 Glomerulus QTL 8 7 9e-09 kidney glomerulus morphology trait (VT:0005325) count of superficial glomeruli directly contacting the kidney surface (CMO:0001001) 6 86894788 131894788 Rat 2293085 Iddm29 Insulin dependent diabetes mellitus QTL 29 7.66 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 6 122549046 140286318 Rat
D6Mgh3
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 6 122,549,046 - 122,549,218 (+) MAPPER mRatBN7.2 Rnor_6.0 6 127,286,494 - 127,286,661 NCBI Rnor6.0 Rnor_5.0 6 136,507,025 - 136,507,192 UniSTS Rnor5.0 RGSC_v3.4 6 127,683,728 - 127,683,895 RGD RGSC3.4 RGSC_v3.4 6 127,683,729 - 127,683,896 UniSTS RGSC3.4 RGSC_v3.1 6 127,687,475 - 127,687,642 RGD Celera 6 120,029,772 - 120,029,922 UniSTS RH 3.4 Map 6 839.1 UniSTS RH 3.4 Map 6 839.1 RGD SHRSP x BN Map 6 77.5898 UniSTS SHRSP x BN Map 6 77.5898 RGD Cytogenetic Map 6 q32 UniSTS
RH133473
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 6 122,563,380 - 122,563,597 (+) MAPPER mRatBN7.2 Rnor_6.0 6 127,300,815 - 127,301,031 NCBI Rnor6.0 Rnor_5.0 6 136,521,346 - 136,521,562 UniSTS Rnor5.0 RGSC_v3.4 6 127,698,050 - 127,698,266 UniSTS RGSC3.4 Celera 6 120,044,074 - 120,044,290 UniSTS RH 3.4 Map 6 836.2 UniSTS Cytogenetic Map 6 q32 UniSTS
BF395820
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 6 122,561,242 - 122,561,356 (+) MAPPER mRatBN7.2 Rnor_6.0 6 127,298,677 - 127,298,790 NCBI Rnor6.0 Rnor_5.0 6 136,519,208 - 136,519,321 UniSTS Rnor5.0 RGSC_v3.4 6 127,695,912 - 127,696,025 UniSTS RGSC3.4 Celera 6 120,041,936 - 120,042,049 UniSTS RH 3.4 Map 6 838.11 UniSTS Cytogenetic Map 6 q32 UniSTS
Click on a value in the shaded box below the category label to view a detailed expression data table for that system.
alimentary part of gastrointestinal system
9
11
49
113
91
90
59
25
59
6
218
97
93
45
60
31
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Ensembl Acc Id:
ENSRNOT00000012124 ⟹ ENSRNOP00000012124
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 6 122,545,073 - 122,563,644 (+) Ensembl Rnor_6.0 Ensembl 6 127,282,466 - 127,301,083 (+) Ensembl
Ensembl Acc Id:
ENSRNOT00000113696 ⟹ ENSRNOP00000081107
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 6 122,545,061 - 122,561,891 (+) Ensembl
RefSeq Acc Id:
NM_001108053 ⟹ NP_001101523
RefSeq Status:
VALIDATED
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 6 128,309,863 - 128,328,444 (+) NCBI mRatBN7.2 6 122,545,067 - 122,563,657 (+) NCBI Rnor_6.0 6 127,282,466 - 127,301,083 (+) NCBI Rnor_5.0 6 136,503,029 - 136,521,616 (+) NCBI RGSC_v3.4 6 127,679,755 - 127,698,318 (+) RGD Celera 6 120,025,797 - 120,044,342 (+) RGD
Sequence:
GGGCCGTGCGTCTTGCTGGGACACAGTGGAGGTCTGCGCTCCGGTCTGAGGGGCGGTCGGGTGTATTCTGCACTCACCCCACACCCGCGAGGCCCGCGCCGCCCGACCCAACGGCGGAGCCGCCCAGC
hide sequence
RefSeq Acc Id:
NM_001401354 ⟹ NP_001388283
RefSeq Status:
VALIDATED
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 6 128,309,863 - 128,328,444 (+) NCBI mRatBN7.2 6 122,545,067 - 122,563,657 (+) NCBI
RefSeq Acc Id:
NM_001401355 ⟹ NP_001388284
RefSeq Status:
VALIDATED
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 6 128,309,863 - 128,328,444 (+) NCBI mRatBN7.2 6 122,545,067 - 122,563,657 (+) NCBI
RefSeq Acc Id:
NP_001101523 ⟸ NM_001108053
- Peptide Label:
isoform 3
- UniProtKB:
A6JEM6 (UniProtKB/TrEMBL)
- Sequence:
MSETSFNLISEKCDILSILRDHPENRIYQRKIQELSKRFTSIRKTKGDGNCFYRALGYSYLESLLGKGREILKFKERVLQTPNDLLAAGFEEHKFRNFFNAFYSVVELVEKDSSVSSLLKVFNDQSSS
hide sequence
Ensembl Acc Id:
ENSRNOP00000012124 ⟸ ENSRNOT00000012124
Ensembl Acc Id:
ENSRNOP00000081107 ⟸ ENSRNOT00000113696
RefSeq Acc Id:
NP_001388283 ⟸ NM_001401354
- Peptide Label:
isoform 1
- UniProtKB:
D3ZAR8 (UniProtKB/TrEMBL)
RefSeq Acc Id:
NP_001388284 ⟸ NM_001401355
- Peptide Label:
isoform 2
- UniProtKB:
D3ZAR8 (UniProtKB/TrEMBL)
RGD ID: 13694792 Promoter ID: EPDNEW_R5316 Type: initiation region Name: Otub2_1 Description: OTU deubiquitinase, ubiquitin aldehyde binding 2 SO ACC ID: SO:0000170 Source: EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/ ) Experiment Methods: Single-end sequencing. Position: Rat Assembly Chr Position (strand) Source Rnor_6.0 6 127,282,466 - 127,282,526 EPDNEW
Date
Current Symbol
Current Name
Previous Symbol
Previous Name
Description
Reference
Status
2014-03-13
Otub2
OTU deubiquitinase, ubiquitin aldehyde binding 2
Otub2
OTU domain, ubiquitin aldehyde binding 2
Nomenclature updated to reflect human and mouse nomenclature
1299863 APPROVED
2008-04-30
Otub2
OTU domain, ubiquitin aldehyde binding 2
Otub2_predicted
OTU domain, ubiquitin aldehyde binding 2 (predicted)
'predicted' is removed
2292626 APPROVED
2005-01-12
Otub2_predicted
OTU domain, ubiquitin aldehyde binding 2 (predicted)
Symbol and Name status set to approved
70820 APPROVED
