Pgk2 (phosphoglycerate kinase 2) - Rat Genome Database

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Gene: Pgk2 (phosphoglycerate kinase 2) Rattus norvegicus
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Symbol: Pgk2
Name: phosphoglycerate kinase 2
RGD ID: 1306627
Description: Predicted to enable ADP binding activity; ATP binding activity; and phosphoglycerate kinase activity. Predicted to be involved in gluconeogenesis and glycolytic process. Predicted to act upstream of or within flagellated sperm motility. Predicted to be located in cilium. Predicted to be active in cytosol and sperm fibrous sheath. Orthologous to human PGK2 (phosphoglycerate kinase 2); PARTICIPATES IN gluconeogenesis pathway; glycolysis pathway; glycolysis/gluconeogenesis pathway; INTERACTS WITH bisphenol A; fenvalerate; (-)-epigallocatechin 3-gallate (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC316265
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8927,976,913 - 27,978,479 (+)NCBIGRCr8
mRatBN7.2920,480,367 - 20,481,933 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl920,480,203 - 20,571,481 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx929,010,916 - 29,012,482 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0934,114,730 - 34,116,296 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0932,425,549 - 32,427,115 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0924,095,774 - 24,097,340 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl924,095,751 - 24,097,337 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0922,956,349 - 22,957,915 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4916,705,747 - 16,707,313 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1916,703,068 - 16,704,633 (+)NCBI
Celera918,123,078 - 18,124,644 (+)NCBICelera
Cytogenetic Map9q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2823118   PMID:12477932   PMID:16687649   PMID:19759366   PMID:21630459   PMID:23533145   PMID:25002582  


Genomics

Comparative Map Data
Pgk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8927,976,913 - 27,978,479 (+)NCBIGRCr8
mRatBN7.2920,480,367 - 20,481,933 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl920,480,203 - 20,571,481 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx929,010,916 - 29,012,482 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0934,114,730 - 34,116,296 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0932,425,549 - 32,427,115 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0924,095,774 - 24,097,340 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl924,095,751 - 24,097,337 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0922,956,349 - 22,957,915 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4916,705,747 - 16,707,313 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1916,703,068 - 16,704,633 (+)NCBI
Celera918,123,078 - 18,124,644 (+)NCBICelera
Cytogenetic Map9q13NCBI
PGK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38649,785,660 - 49,787,285 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl649,785,660 - 49,787,285 (-)EnsemblGRCh38hg38GRCh38
GRCh37649,753,373 - 49,754,998 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36649,861,323 - 49,862,966 (-)NCBINCBI36Build 36hg18NCBI36
Build 34649,861,324 - 49,862,966NCBI
Celera651,309,449 - 51,311,138 (-)NCBICelera
Cytogenetic Map6p12.3NCBI
HuRef649,483,695 - 49,485,384 (-)NCBIHuRef
CHM1_1649,756,278 - 49,757,967 (-)NCBICHM1_1
T2T-CHM13v2.0649,627,627 - 49,629,252 (-)NCBIT2T-CHM13v2.0
Pgk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391740,517,909 - 40,519,500 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1740,517,906 - 40,519,531 (-)EnsemblGRCm39 Ensembl
GRCm381740,207,018 - 40,208,609 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1740,207,015 - 40,208,640 (-)EnsemblGRCm38mm10GRCm38
MGSCv371740,343,963 - 40,345,554 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361739,670,497 - 39,672,026 (-)NCBIMGSCv36mm8
Celera1743,614,083 - 43,615,674 (-)NCBICelera
Cytogenetic Map17B2NCBI
cM Map1719.44NCBI
Pgk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554118,216,432 - 8,218,065 (+)NCBIChiLan1.0ChiLan1.0
PGK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2564,255,058 - 64,270,523 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1660,120,713 - 60,136,179 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0649,355,154 - 49,356,804 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1650,615,916 - 50,617,599 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl650,616,199 - 50,617,452 (-)Ensemblpanpan1.1panPan2
PGK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11217,616,653 - 17,622,073 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1217,610,662 - 17,622,324 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1217,512,676 - 17,518,089 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01218,110,850 - 18,116,264 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1218,104,848 - 18,116,522 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11217,629,958 - 17,635,375 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01217,736,007 - 17,741,431 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01217,865,686 - 17,871,100 (-)NCBIUU_Cfam_GSD_1.0
PGK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl743,839,241 - 43,840,892 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1743,839,239 - 43,840,892 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2750,231,411 - 50,233,064 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7q14-q15NCBI
PGK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11722,619,062 - 22,621,157 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1722,619,615 - 22,620,868 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604449,758,034 - 49,759,685 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pgk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479914,621,673 - 14,622,926 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479914,621,413 - 14,623,050 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pgk2
5 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:188
Count of miRNA genes:127
Interacting mature miRNAs:137
Transcripts:ENSRNOT00000018177
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)9795472022071169Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat
724543Cm20Cardiac mass QTL 203.9heart mass (VT:0007028)calculated heart weight (CMO:0000073)91696139840594091Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat

Markers in Region
BE106404  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2920,481,700 - 20,481,851 (+)MAPPERmRatBN7.2
Rnor_6.0924,097,108 - 24,097,258NCBIRnor6.0
Rnor_5.0922,957,683 - 22,957,833UniSTSRnor5.0
RGSC_v3.4916,707,081 - 16,707,231UniSTSRGSC3.4
Celera918,124,412 - 18,124,562UniSTS
RH 3.4 Map9175.5UniSTS
Cytogenetic Map9q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1
Medium 6
Low 2 2 1 1 2
Below cutoff 1 2 9 7 8 7 3 5 6 2 5 4 3

Sequence


RefSeq Acc Id: ENSRNOT00000018177   ⟹   ENSRNOP00000018177
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl920,480,203 - 20,554,260 (+)Ensembl
Rnor_6.0 Ensembl924,095,751 - 24,097,337 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000112647   ⟹   ENSRNOP00000094932
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl920,480,203 - 20,555,169 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115954   ⟹   ENSRNOP00000081650
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl920,480,203 - 20,571,481 (+)Ensembl
RefSeq Acc Id: NM_001012130   ⟹   NP_001012130
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8927,976,913 - 27,978,479 (+)NCBI
mRatBN7.2920,480,367 - 20,481,933 (+)NCBI
Rnor_6.0924,095,774 - 24,097,340 (+)NCBI
Rnor_5.0922,956,349 - 22,957,915 (+)NCBI
RGSC_v3.4916,705,747 - 16,707,313 (+)RGD
Celera918,123,078 - 18,124,644 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001012130 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH83568 (Get FASTA)   NCBI Sequence Viewer  
  EDM18667 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018177
  ENSRNOP00000018177.4
  ENSRNOP00000081650.1
  ENSRNOP00000094932.1
RefSeq Acc Id: NP_001012130   ⟸   NM_001012130
- UniProtKB: Q5XIV1 (UniProtKB/TrEMBL),   A6JJ65 (UniProtKB/TrEMBL),   A0A8I5ZS38 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018177   ⟸   ENSRNOT00000018177
RefSeq Acc Id: ENSRNOP00000081650   ⟸   ENSRNOT00000115954
RefSeq Acc Id: ENSRNOP00000094932   ⟸   ENSRNOT00000112647

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XIV1-F1-model_v2 AlphaFold Q5XIV1 1-417 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696569
Promoter ID:EPDNEW_R7093
Type:initiation region
Name:Pgk2_1
Description:phosphoglycerate kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0924,095,792 - 24,095,852EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306627 AgrOrtholog
BioCyc Gene G2FUF-28071 BioCyc
BioCyc Pathway ANAGLYCOLYSIS-PWY [glycolysis III (from glucose)] BioCyc
  PWY66-399 [gluconeogenesis III] BioCyc
BioCyc Pathway Image ANAGLYCOLYSIS-PWY BioCyc
  PWY66-399 BioCyc
Ensembl Genes ENSRNOG00000013600 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018177 ENTREZGENE
  ENSRNOT00000018177.6 UniProtKB/TrEMBL
  ENSRNOT00000112647.1 UniProtKB/TrEMBL
  ENSRNOT00000115954.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1260 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7111073 IMAGE-MGC_LOAD
InterPro Phosphoglycerate_kinase UniProtKB/TrEMBL
  Phosphoglycerate_kinase_CS UniProtKB/TrEMBL
  Phosphoglycerate_kinase_N UniProtKB/TrEMBL
  Phosphoglycerate_kinase_sf UniProtKB/TrEMBL
KEGG Report rno:316265 UniProtKB/TrEMBL
MGC_CLONE MGC:93835 IMAGE-MGC_LOAD
NCBI Gene 316265 ENTREZGENE
PANTHER PGK UniProtKB/TrEMBL
  PHOSPHOGLYCERATE KINASE 2 UniProtKB/TrEMBL
Pfam PGK UniProtKB/TrEMBL
PhenoGen Pgk2 PhenoGen
PIRSF Pgk UniProtKB/TrEMBL
PRINTS PHGLYCKINASE UniProtKB/TrEMBL
PROSITE PGLYCERATE_KINASE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013600 RatGTEx
Superfamily-SCOP PGK UniProtKB/TrEMBL
UniProt A0A8I5ZS38 ENTREZGENE, UniProtKB/TrEMBL
  A6JJ65 ENTREZGENE
  Q5XIV1 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A6JJ65 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Pgk2  phosphoglycerate kinase 2  Pgk2_predicted  phosphoglycerate kinase 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Pgk2_predicted  phosphoglycerate kinase 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED