1. |
Acylated and unacylated ghrelin attenuate isoproterenol-induced lipolysis in isolated rat visceral adipocytes through activation of phosphoinositide 3-kinase gamma and phosphodiesterase 3B. |
Baragli A, etal., Biochim Biophys Acta. 2011 Jun;1811(6):386-96. Epub 2011 Mar 22.
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2. |
Class IB-phosphatidylinositol 3-kinase (PI3K) deficiency ameliorates IA-PI3K-induced systemic lupus but not T cell invasion. |
Barber DF, etal., J Immunol. 2006 Jan 1;176(1):589-93.
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3. |
PI3Kgamma within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance. |
Becattini B, etal., Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):E854-63. Epub 2011 Sep 26.
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4. |
A specific role of phosphatidylinositol 3-kinase gamma. A regulation of autonomic Ca(2)+ oscillations in cardiac cells. |
Bony C, etal., J Cell Biol. 2001 Feb 19;152(4):717-28.
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5. |
PI3Kgamma controls leukocyte recruitment, tissue injury, and lethality in a model of graft-versus-host disease in mice. |
Castor MG, etal., J Leukoc Biol. 2011 Jun;89(6):955-64. Epub 2011 Mar 14.
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6. |
Improvement of the resistance against early Mycobacterium tuberculosis-infection in the absence of PI3Kγ enzyme is associated with increase of CD4+IL-17+ cells and neutrophils. |
Cavalcanti-Neto MP, etal., Tuberculosis (Edinb). 2018 Dec;113:1-9. doi: 10.1016/j.tube.2018.08.009. Epub 2018 Aug 23.
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7. |
Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosis. |
Chang JD, etal., Proc Natl Acad Sci U S A. 2007 May 8;104(19):8077-82. Epub 2007 May 2.
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8. |
S100B-mediated protection against the pro-apoptotic effects of ethanol on fetal rhombencephalic neurons. |
Druse MJ, etal., Brain Res. 2007 May 30;1150:46-54. Epub 2007 Mar 13.
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9. |
Inhibitor of PI3Kgamma ameliorates TNBS-induced colitis in mice by affecting the functional activity of CD4+CD25+FoxP3+ regulatory T cells. |
Dutra RC, etal., Br J Pharmacol. 2011 May;163(2):358-74. doi: 10.1111/j.1476-5381.2011.01226.x.
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10. |
Key role of phosphoinositide 3-kinase class IB in pancreatic cancer. |
Edling CE, etal., Clin Cancer Res. 2010 Oct 15;16(20):4928-37. doi: 10.1158/1078-0432.CCR-10-1210. Epub 2010 Sep 28.
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11. |
Phosphoinositide 3-Kinase {gamma} Inhibition Plays a Crucial Role in Early Steps of Inflammation by Blocking Neutrophil Recruitment. |
Ferrandi C, etal., J Pharmacol Exp Ther. 2007 Sep;322(3):923-30. Epub 2007 May 25.
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12. |
Phosphatidyl Inositol 3 Kinase-Gamma Balances Antiviral and Inflammatory Responses During Influenza A H1N1 Infection: From Murine Model to Genetic Association in Patients. |
Garcia CC, etal., Front Immunol. 2018 May 15;9:975. doi: 10.3389/fimmu.2018.00975. eCollection 2018.
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13. |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. |
Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
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14. |
Rat ISS GO annotations from GOA human gene data--August 2006 |
GOA data from the GO Consortium
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15. |
Phosphatidylinositol 3-kinase gamma inhibition ameliorates inflammation and tumor growth in a model of colitis-associated cancer. |
Gonzalez-Garcia A, etal., Gastroenterology. 2010 Apr;138(4):1374-83. Epub 2009 Dec 11.
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16. |
Loss of phosphoinositide 3-kinase gamma decreases migration and activation of phagocytes but not T cell activation in antigen-induced arthritis. |
Gruen M, etal., BMC Musculoskelet Disord. 2010 Apr 7;11:63.
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17. |
Activation of PI3Kγ/Akt pathway mediates bone cancer pain in rats. |
Guan X, etal., J Neurochem. 2015 Aug;134(3):590-600. doi: 10.1111/jnc.13139. Epub 2015 Jun 4.
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18. |
PI3Kgamma protects from myocardial ischemia and reperfusion injury through a kinase-independent pathway. |
Haubner BJ, etal., PLoS One. 2010 Feb 22;5(2):e9350.
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19. |
Phosphatidylinositol-3-kinase p110gamma contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cells. |
Hohenester S, etal., J Hepatol. 2010 Nov;53(5):918-26. Epub 2010 Jul 17.
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20. |
Effect of miR-182 on hepatic fibrosis induced by Schistosomiasis japonica by targeting FOXO1 through PI3K/AKT signaling pathway. |
Huang Y, etal., J Cell Physiol. 2018 Oct;233(10):6693-6704. doi: 10.1002/jcp.26469. Epub 2018 Apr 25.
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21. |
Prolactin-stimulated transepithelial calcium transport in duodenum and Caco-2 monolayer are mediated by the phosphoinositide 3-kinase pathway. |
Jantarajit W, etal., Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E372-84. Epub 2007 May 8.
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22. |
Phosphatidylinositol-3-kinase gamma plays a central role in blood-brain barrier dysfunction in acute experimental stroke. |
Jin R, etal., Stroke. 2011 Jul;42(7):2033-44. Epub 2011 May 5.
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23. |
Platelet-derived growth factor-BB-mediated activation of Akt suppresses smooth muscle-specific gene expression through inhibition of mitogen-activated protein kinase and redistribution of serum response factor. |
Kaplan-Albuquerque N, etal., J Biol Chem. 2003 Oct 10;278(41):39830-8. Epub 2003 Jul 25.
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24. |
PI3K-gamma inhibition ameliorates acute lung injury through regulation of IkappaBalpha/NF-kappaB pathway and innate immune responses. |
Kim DI, etal., J Clin Immunol. 2012 Apr;32(2):340-51. Epub 2011 Dec 24.
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25. |
Loss of insulin-mediated vasoprotection: early effect of diabetes on pericyte-containing microvessels of the retina. |
Kobayashi T and Puro DG, Invest Ophthalmol Vis Sci. 2007 May;48(5):2350-5.
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26. |
Phosphatidylinositol 3-Kinase γ is required for the development of experimental cerebral malaria. |
Lacerda-Queiroz N, etal., PLoS One. 2015 Mar 16;10(3):e0119633. doi: 10.1371/journal.pone.0119633. eCollection 2015.
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27. |
Lack of phosphoinositide 3-kinase-gamma attenuates ventilator-induced lung injury. |
Lionetti V, etal., Crit Care Med. 2006 Jan;34(1):134-41.
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28. |
Repression of microRNA-21 inhibits retinal vascular endothelial cell growth and angiogenesis via PTEN dependent-PI3K/Akt/VEGF signaling pathway in diabetic retinopathy. |
Lu JM, etal., Exp Eye Res. 2020 Jan;190:107886. doi: 10.1016/j.exer.2019.107886. Epub 2019 Nov 21.
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29. |
PI3Kγ mediates kaposi's sarcoma-associated herpesvirus vGPCR-induced sarcomagenesis. |
Martin D, etal., Cancer Cell. 2011 Jun 14;19(6):805-13. doi: 10.1016/j.ccr.2011.05.005.
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30. |
Phosphoinositide-3 kinase gamma activity contributes to sepsis and organ damage by altering neutrophil recruitment. |
Martin EL, etal., Am J Respir Crit Care Med. 2010 Sep 15;182(6):762-73. Epub 2010 May 27.
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31. |
Importance of phosphoinositide 3-kinase gamma in the host defense against pneumococcal infection. |
Maus UA, etal., Am J Respir Crit Care Med. 2007 May 1;175(9):958-66. doi: 10.1164/rccm.200610-1533OC. Epub 2007 Feb 22.
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32. |
Rat ISS GO annotations from MGI mouse gene data--August 2006 |
MGD data from the GO Consortium
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33. |
Novel roles of local insulin-like growth factor-1 activation in gastric ulcer healing: promotes actin polymerization, cell proliferation, re-epithelialization, and induces cyclooxygenase-2 in a phosphatidylinositol 3-kinase-dependent manner. |
Nguyen T, etal., Am J Pathol. 2007 Apr;170(4):1219-28.
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34. |
Involvement of phosphoinositide 3-kinase gamma in the neuro-inflammatory response and cognitive impairments induced by beta-amyloid 1-40 peptide in mice. |
Passos GF, etal., Brain Behav Immun. 2010 Mar;24(3):493-501. Epub 2009 Dec 16.
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35. |
Targeted inhibition of beta-adrenergic receptor kinase-1-associated phosphoinositide-3 kinase activity preserves beta-adrenergic receptor signaling and prolongs survival in heart failure induced by calsequestrin overexpression. |
Perrino C, etal., J Am Coll Cardiol. 2005 Jun 7;45(11):1862-70.
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36. |
Insulin granule recruitment and exocytosis is dependent on p110gamma in insulinoma and human beta-cells. |
Pigeau GM, etal., Diabetes. 2009 Sep;58(9):2084-92. Epub 2009 Jun 23.
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37. |
PID Annotation Import Pipeline |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD
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38. |
SMPDB Annotation Import Pipeline |
Pipeline to import SMPDB annotations from SMPDB into RGD
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39. |
Role of PI3Kdelta and PI3Kgamma in inflammatory arthritis and tissue localization of neutrophils. |
Randis TM, etal., Eur J Immunol. 2008 May;38(5):1215-24.
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40. |
GOA pipeline |
RGD automated data pipeline
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41. |
ClinVar Automated Import and Annotation Pipeline |
RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
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42. |
Data Import for Chemical-Gene Interactions |
RGD automated import pipeline for gene-chemical interactions
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43. |
Comprehensive gene review and curation |
RGD comprehensive gene curation
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44. |
Absence of PI3Kgamma leads to increased leukocyte apoptosis and diminished severity of experimental autoimmune encephalomyelitis. |
Rodrigues DH, etal., J Neuroimmunol. 2010 May;222(1-2):90-4. Epub 2010 Mar 19.
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45. |
Frontline Science: Coincidental null mutation of Csf2rα in a colony of PI3Kγ-/- mice causes alveolar macrophage deficiency and fatal respiratory viral infection. |
Schneider C, etal., J Leukoc Biol. 2017 Feb;101(2):367-376. doi: 10.1189/jlb.4HI0316-157R. Epub 2016 Jul 28.
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46. |
Association of INPP1, PIK3CG, and TSC2 gene variants with autistic disorder: implications for phosphatidylinositol signalling in autism. |
Serajee FJ, etal., J Med Genet. 2003 Nov;40(11):e119.
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47. |
Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis. |
Silva MC, etal., Nat Commun. 2018 Apr 17;9(1):1513. doi: 10.1038/s41467-018-03986-3.
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48. |
Involvement of phosphoinositide 3-kinase gamma in angiogenesis and healing of experimental myocardial infarction in mice. |
Siragusa M, etal., Circ Res. 2010 Mar 5;106(4):757-68. Epub 2010 Jan 7.
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49. |
[The antagonistic effect of PI3K-gamma inhibitor AS605240 on cardiac hypertrophy and cardiac fibrosis induced by isoproterenol in rats]. |
Song LF, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2011 Jul;42(4):471-4.
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50. |
Phosphatidylinositol 3-kinase-γ signaling promotes Campylobacter jejuni-induced colitis through neutrophil recruitment in mice. |
Sun X, etal., J Immunol. 2013 Jan 1;190(1):357-65. doi: 10.4049/jimmunol.1201825. Epub 2012 Nov 23.
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51. |
Essential role of phosphoinositide 3-kinase gamma in eosinophil chemotaxis within acute pulmonary inflammation. |
Thomas M, etal., Immunology. 2009 Mar;126(3):413-22. Epub 2008 Aug 27.
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52. |
Cardioprotection induced by olprinone, a phosphodiesterase III inhibitor, involves phosphatidylinositol-3-OH kinase-Akt and a mitochondrial permeability transition pore during early reperfusion. |
Tosaka S, etal., J Anesth. 2007;21(2):176-80. Epub 2007 May 30.
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53. |
The absence of functional PI3Kgamma prevents leukocyte recruitment and ameliorates DSS-induced colitis in mice. |
van Dop WA, etal., Immunol Lett. 2010 Jun 15;131(1):33-9. doi: 10.1016/j.imlet.2010.03.008. Epub 2010 Mar 27.
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54. |
CDK2 regulation through PI3K and CDK4 is necessary for cell cycle progression of primary rat hepatocytes. |
Wierod L, etal., Cell Prolif. 2007 Aug;40(4):475-87.
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55. |
The alarmin cytokine, high mobility group box 1, is produced by viable cardiomyocytes and mediates the lipopolysaccharide-induced myocardial dysfunction via a TLR4/phosphatidylinositol 3-kinase gamma pathway. |
Xu H, etal., J Immunol. 2010 Feb 1;184(3):1492-8. doi: 10.4049/jimmunol.0902660. Epub 2009 Dec 18.
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56. |
The PI3K/Akt pathway mediates the nongenomic cardioprotective effects of estrogen following trauma-hemorrhage. |
Yu HP, etal., Ann Surg. 2007 Jun;245(6):971-7.
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57. |
Tissue kallikrein reverses insulin resistance and attenuates nephropathy in diabetic rats by activation of phosphatidylinositol 3-kinase/protein kinase B and adenosine 5'-monophosphate-activated protein kinase signaling pathways. |
Yuan G, etal., Endocrinology. 2007 May;148(5):2016-26. Epub 2007 Feb 1.
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58. |
Involvement of phosphoinositide 3-kinases in neutrophil activation and the development of acute lung injury. |
Yum HK, etal., J Immunol. 2001 Dec 1;167(11):6601-8. doi: 10.4049/jimmunol.167.11.6601.
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59. |
Stimulatory effect of puerarin on bone formation through activation of PI3K/Akt pathway in rat calvaria osteoblasts. |
Zhang Y, etal., Planta Med. 2007 Apr;73(4):341-7. Epub 2007 Apr 18.
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