Uchl5 (ubiquitin C-terminal hydrolase L5) - Rat Genome Database

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Gene: Uchl5 (ubiquitin C-terminal hydrolase L5) Rattus norvegicus
Analyze
Symbol: Uchl5
Name: ubiquitin C-terminal hydrolase L5
RGD ID: 1305414
Description: Predicted to enable cysteine-type deubiquitinase activity; endopeptidase inhibitor activity; and proteasome binding activity. Predicted to be involved in several processes, including brain development; positive regulation of smoothened signaling pathway; and regulation of nucleobase-containing compound metabolic process. Part of cytosolic proteasome complex. Orthologous to human UCHL5 (ubiquitin C-terminal hydrolase L5); PARTICIPATES IN INO80 family mediated chromatin remodeling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC360853; ubiquitin carboxyl-terminal esterase L5; ubiquitin carboxyl-terminal hydrolase isozyme L5; ubiquitin carboxyl-terminal hydrolase L5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81358,070,947 - 58,106,825 (+)NCBIGRCr8
mRatBN7.21355,520,722 - 55,556,503 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1355,520,729 - 55,556,502 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1358,089,283 - 58,125,040 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01359,356,425 - 59,392,187 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01356,641,812 - 56,677,555 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01360,568,102 - 60,603,812 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1360,545,635 - 60,603,811 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01365,556,665 - 65,592,649 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41357,605,912 - 57,643,050 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11357,619,991 - 57,908,156 (+)NCBI
Celera1355,608,483 - 55,644,135 (+)NCBICelera
Cytogenetic Map13q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Uchl5RatAlcoholic Liver Diseases  IEP 9480236protein:decreased expression:liver and cytosolic proteasome complexRGD 
Uchl5RatExperimental Diabetes Mellitus  IEP 9588239 RGD 
Uchl5RatTestis Reperfusion Injury  IEP 9588240mRNA and protein:decreased expression:testisRGD 
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
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Original Reference(s)
Uchl5Ratgastrointestinal stromal tumor  ISOUCHL5 (Homo sapiens)8554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
Uchl5RatHyperparathyroidism 1  ISOUCHL5 (Homo sapiens)8554872ClinVar Annotator: match by term: Hyperparathyroidism 1ClinVarPMID:21681106 and PMID:28774260
Uchl5Ratparathyroid carcinoma  ISOUCHL5 (Homo sapiens)8554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532

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Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
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Original Reference(s)
Uchl5Rat1,2-dimethylhydrazine decreases expressionISOUchl5 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of UCHL5 mRNACTDPMID:22206623
Uchl5Rat1,2-dimethylhydrazine multiple interactionsISOUchl5 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of UCHL5 mRNACTDPMID:22206623
Uchl5Rat1-chloro-2,4-dinitrobenzene affects bindingISOUCHL5 (Homo sapiens)6480464Dinitrochlorobenzene binds to UCHL5 proteinCTDPMID:32991956
Uchl5Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOUchl5 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of UCHL5 mRNACTDPMID:21570461
Uchl5Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of UCHL5 mRNACTDPMID:33387578
Uchl5Rat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of UCHL5 mRNACTDPMID:21346803
Uchl5Rat2-methylcholine affects expressionISOUCHL5 (Homo sapiens)6480464beta-methylcholine affects the expression of UCHL5 mRNACTDPMID:21179406
Uchl5Rat3,3',4,4',5-pentachlorobiphenyl increases expressionEXP 64804643 more ...CTDPMID:23196670
Uchl5Rat4,4'-diaminodiphenylmethane affects expressionISOUchl5 (Mus musculus)64804644 and 4'-diaminodiphenylmethane affects the expression of UCHL5 mRNACTDPMID:18648102
Uchl5Rat4,4'-sulfonyldiphenol affects expressionISOUCHL5 (Homo sapiens)6480464bisphenol S affects the expression of UCHL5 proteinCTDPMID:31945527
Uchl5Rat4,4'-sulfonyldiphenol increases expressionISOUCHL5 (Homo sapiens)6480464bisphenol S results in increased expression of UCHL5 proteinCTDPMID:34186270
Uchl5Rat4,4'-sulfonyldiphenol decreases methylationISOUCHL5 (Homo sapiens)6480464bisphenol S results in decreased methylation of UCHL5 geneCTDPMID:31601247
Uchl5Rat4-phenylbutyric acid multiple interactionsEXP 64804644-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of UCHL5 protein]CTDPMID:30980806
Uchl5Rataflatoxin B1 decreases methylationISOUCHL5 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of UCHL5 geneCTDPMID:27153756
Uchl5Ratall-trans-retinoic acid decreases expressionISOUCHL5 (Homo sapiens)6480464Tretinoin results in decreased expression of UCHL5 mRNACTDPMID:21934132 and PMID:33167477
Uchl5Rataristolochic acid A decreases expressionISOUCHL5 (Homo sapiens)6480464aristolochic acid I results in decreased expression of UCHL5 mRNACTDPMID:33212167
Uchl5Rataristolochic acid A increases expressionISOUchl5 (Mus musculus)6480464aristolochic acid I results in increased expression of UCHL5 mRNA and aristolochic acid I results in increased expression of UCHL5 proteinCTDPMID:26108275
Uchl5RatAroclor 1254 decreases expressionISOUchl5 (Mus musculus)6480464Chlorodiphenyl (54% Chlorine) results in decreased expression of UCHL5 mRNACTDPMID:23650126
Uchl5Ratarsane multiple interactionsISOUCHL5 (Homo sapiens)6480464[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of UCHL5 mRNACTDPMID:39836092
Uchl5Ratarsenic atom multiple interactionsISOUCHL5 (Homo sapiens)6480464[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of UCHL5 mRNACTDPMID:39836092

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Biological Process
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Object Symbol
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Original Reference(s)
Uchl5Ratbiological_process  ND 159840710/2014: no relevant rat dataRGD 
Uchl5Ratchromatin remodeling involved_inISOUCHL5 (Homo sapiens)1624291 PMID:21303910RGDPMID:21303910
Uchl5Ratforebrain morphogenesis involved_inISOUchl5 (Mus musculus)1624291 PMID:21048919RGDPMID:21048919
Uchl5Ratlateral ventricle development involved_inISOUchl5 (Mus musculus)1624291 PMID:21048919RGDPMID:21048919
Uchl5Ratmidbrain development involved_inISOUchl5 (Mus musculus)1624291 PMID:21048919RGDPMID:21048919
Uchl5Ratnegative regulation of proteasomal ubiquitin-dependent protein catabolic process involved_inISOUCHL5 (Homo sapiens)1624291 PMID:23770237RGDPMID:23770237
Uchl5Ratpositive regulation of DNA repair involved_inISOUchl5 (Mus musculus)1624291 PMID:23979016RGDPMID:23979016
Uchl5Ratpositive regulation of DNA-templated transcription involved_inISOUCHL5 (Homo sapiens)1624291 PMID:27641337RGDPMID:27641337
Uchl5Ratpositive regulation of smoothened signaling pathway involved_inISOUCHL5 (Homo sapiens)1624291 PMID:28992318RGDPMID:28992318
Uchl5Ratpositive regulation of telomere maintenance in response to DNA damage involved_inISOUchl5 (Mus musculus)1624291 PMID:23979016RGDPMID:23979016
Uchl5Ratprotein deubiquitination involved_inISOUCHL5 (Homo sapiens)1624291 PMID:18922472RGDPMID:18922472
Uchl5Ratprotein deubiquitination involved_inIEAInterPro:IPR017390 and InterPro:IPR0338371600115GO_REF:0000002InterProGO_REF:0000002
Uchl5Ratproteolysis involved_inIEAUniProtKB-KW:KW-06451600115GO_REF:0000043UniProtGO_REF:0000043
Uchl5Ratregulation of cell cycle involved_inISOUCHL5 (Homo sapiens)1624291 PMID:26340092RGDPMID:26340092
Uchl5Ratregulation of chromosome organization involved_inISOUCHL5 (Homo sapiens)1624291 PMID:26340092RGDPMID:26340092
Uchl5Ratregulation of chromosome organization involved_inIBAMGI:1914848 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Uchl5Ratregulation of DNA repair involved_inISOUchl5 (Mus musculus)1624291 PMID:23979016RGDPMID:23979016
Uchl5Ratregulation of DNA replication involved_inISOUCHL5 (Homo sapiens)1624291 PMID:25016522RGDPMID:25016522
Uchl5Ratregulation of DNA strand elongation involved_inISOUCHL5 (Homo sapiens)1624291 PMID:25016522RGDPMID:25016522
Uchl5Ratregulation of embryonic development involved_inISOUchl5 (Mus musculus)1624291 PMID:23979016RGDPMID:23979016
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Cellular Component
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Molecular Function
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Object Symbol
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Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Uchl5Ratcysteine-type deubiquitinase activity enablesISOUCHL5 (Homo sapiens)1624291 PMID:18922472 and PMID:28992318RGDPMID:18922472 and PMID:28992318
Uchl5Ratcysteine-type deubiquitinase activity enablesIBAFB:FBgn0010288 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Uchl5Ratcysteine-type deubiquitinase activity enablesIEAEC:3.4.19.121600115GO_REF:0000003UniProtGO_REF:0000003
Uchl5Ratcysteine-type deubiquitinase activity enablesIEAInterPro:IPR001578 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Uchl5Ratcysteine-type deubiquitinase activity enablesIEAUniRule:UR0003568091600115GO_REF:0000104UniProtGO_REF:0000104
Uchl5Ratcysteine-type peptidase activity enablesIEAUniProtKB-KW:KW-07881600115GO_REF:0000043UniProtGO_REF:0000043
Uchl5Ratendopeptidase inhibitor activity enablesISOUCHL5 (Homo sapiens)1624291 PMID:18162577RGDPMID:18162577
Uchl5Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Uchl5Ratpeptidase activity enablesIEAUniProtKB-KW:KW-06451600115GO_REF:0000043UniProtGO_REF:0000043
Uchl5Ratproteasome binding enablesISOUCHL5 (Homo sapiens)1624291 PMID:18162577 and PMID:18922472RGDPMID:18162577 and PMID:18922472
Uchl5Ratproteasome binding enablesIEAInterPro:IPR0338371600115GO_REF:0000002InterProGO_REF:0000002
Uchl5Ratprotein binding enablesISOUCHL5 (Homo sapiens)1624291UniProtKB:O96006 more ...RGDPMID:11163772 more ...
Uchl5Ratprotein binding enablesISOUCHL5 (Homo sapiens) and UniProtKB:Q9Y5K5-31624291UniProtKB:Q16186 more ...RGDPMID:27107012 and PMID:32296183
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RGD Manual Annotations


  
Object Symbol
Species
Term
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Evidence
With
Reference
Notes
Source
Original Reference(s)
Uchl5RatINO80 family mediated chromatin remodeling pathway  ISOUCHL5 (Homo sapiens)9495926 RGD 

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#
Reference Title
Reference Citation
1. Chronic ethanol feeding affects proteasome-interacting proteins. Bousquet-Dubouch MP, etal., Proteomics. 2009 Jul;9(13):3609-22. doi: 10.1002/pmic.200800959.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Ubiquitin C-terminal hydrolase-L5 is required for high glucose-induced transforming growth factor-beta receptor I expression and hypertrophy in mesangial cells. Ko YM, etal., Arch Biochem Biophys. 2013 Jul 15;535(2):177-86. doi: 10.1016/j.abb.2013.03.003. Epub 2013 Mar 13.
5. Proteomic analysis of testicular ischemia-reperfusion injury in rats. Ouh IO, etal., J Vet Med Sci. 2014 Mar;76(3):313-21. Epub 2013 Nov 1.
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. The INO80 family of chromatin-remodeling enzymes: regulators of histone variant dynamics. Watanabe S and Peterson CL, Cold Spring Harb Symp Quant Biol. 2010;75:35-42. doi: 10.1101/sqb.2010.75.063. Epub 2011 Apr 18.
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PMID:12477932   PMID:18162577   PMID:18922472   PMID:19182904   PMID:21048919   PMID:21303910   PMID:22658674   PMID:23770237   PMID:28992318  



Uchl5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81358,070,947 - 58,106,825 (+)NCBIGRCr8
mRatBN7.21355,520,722 - 55,556,503 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1355,520,729 - 55,556,502 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1358,089,283 - 58,125,040 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01359,356,425 - 59,392,187 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01356,641,812 - 56,677,555 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01360,568,102 - 60,603,812 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1360,545,635 - 60,603,811 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01365,556,665 - 65,592,649 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41357,605,912 - 57,643,050 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11357,619,991 - 57,908,156 (+)NCBI
Celera1355,608,483 - 55,644,135 (+)NCBICelera
Cytogenetic Map13q21NCBI
UCHL5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381193,012,254 - 193,060,076 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1193,012,250 - 193,060,080 (-)EnsemblGRCh38hg38GRCh38
GRCh371192,981,384 - 193,029,206 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361191,251,522 - 191,295,144 (-)NCBINCBI36Build 36hg18NCBI36
Build 341189,716,556 - 189,760,178NCBI
Celera1166,094,514 - 166,138,132 (-)NCBICelera
Cytogenetic Map1q31.2NCBI
HuRef1164,217,286 - 164,265,038 (-)NCBIHuRef
CHM1_11194,403,215 - 194,450,956 (-)NCBICHM1_1
T2T-CHM13v2.01192,359,462 - 192,407,284 (-)NCBIT2T-CHM13v2.0
Uchl5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391143,652,993 - 143,683,204 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1143,653,010 - 143,683,204 (+)EnsemblGRCm39 Ensembl
GRCm381143,777,234 - 143,807,466 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1143,777,272 - 143,807,466 (+)EnsemblGRCm38mm10GRCm38
MGSCv371145,624,408 - 145,654,596 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361145,539,553 - 145,569,033 (+)NCBIMGSCv36mm8
Celera1146,352,307 - 146,382,478 (+)NCBICelera
Cytogenetic Map1FNCBI
cM Map162.54NCBI
Uchl5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540630,432,652 - 30,468,741 (-)NCBIChiLan1.0ChiLan1.0
UCHL5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2156,732,736 - 56,780,775 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1156,396,699 - 56,444,658 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01168,471,501 - 168,519,366 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11172,764,606 - 172,812,502 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1172,764,606 - 172,811,880 (-)Ensemblpanpan1.1panPan2
UCHL5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1386,004,595 - 6,045,999 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl386,004,659 - 6,113,714 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha386,102,225 - 6,143,345 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0386,021,866 - 6,063,304 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl386,021,819 - 6,125,039 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1386,021,177 - 6,062,576 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0386,386,756 - 6,427,852 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0386,615,571 - 6,657,212 (+)NCBIUU_Cfam_GSD_1.0
Uchl5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934480,855,144 - 80,907,329 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366381,242,893 - 1,290,512 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366381,242,950 - 1,289,376 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UCHL5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl10725,561 - 763,985 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.110725,688 - 761,633 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2102,258,893 - 2,274,919 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UCHL5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12536,362,340 - 36,415,550 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2536,364,027 - 36,414,762 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605537,311,867 - 37,365,433 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Uchl5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624814529,084 - 567,666 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624814529,100 - 568,387 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Uchl5
126 total Variants

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:50
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000004881
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134372077062022792Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat

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alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 17 of 17 rows
RefSeq Transcripts NM_001393849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001393850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001393851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_172020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_190751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC088841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 17 of 17 rows

Ensembl Acc Id: ENSRNOT00000004881   ⟹   ENSRNOP00000004881
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1355,520,768 - 55,556,502 (+)Ensembl
Rnor_6.0 Ensembl1360,568,146 - 60,603,811 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077153   ⟹   ENSRNOP00000072164
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1355,527,046 - 55,556,133 (+)Ensembl
Rnor_6.0 Ensembl1360,545,635 - 60,603,438 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098889   ⟹   ENSRNOP00000094138
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1355,520,729 - 55,556,133 (+)Ensembl
RefSeq Acc Id: NM_001393849   ⟹   NP_001380778
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81358,071,076 - 58,106,825 (+)NCBI
mRatBN7.21355,520,752 - 55,556,503 (+)NCBI
RefSeq Acc Id: NM_001393850   ⟹   NP_001380779
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81358,071,076 - 58,106,825 (+)NCBI
mRatBN7.21355,520,752 - 55,556,503 (+)NCBI
RefSeq Acc Id: NM_001393851   ⟹   NP_001380780
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81358,071,076 - 58,106,825 (+)NCBI
mRatBN7.21355,520,752 - 55,556,503 (+)NCBI
RefSeq Acc Id: NR_172020
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81358,071,076 - 58,106,825 (+)NCBI
mRatBN7.21355,520,752 - 55,556,503 (+)NCBI
RefSeq Acc Id: XM_039090901   ⟹   XP_038946829
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81358,071,002 - 58,106,451 (+)NCBI
mRatBN7.21355,520,723 - 55,552,368 (+)NCBI
RefSeq Acc Id: XM_063272472   ⟹   XP_063128542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81358,070,947 - 58,106,451 (+)NCBI
Ensembl Acc Id: ENSRNOP00000072164   ⟸   ENSRNOT00000077153
Ensembl Acc Id: ENSRNOP00000004881   ⟸   ENSRNOT00000004881
RefSeq Acc Id: XP_038946829   ⟸   XM_039090901
- Peptide Label: isoform X1
- UniProtKB: Q5HZY3 (UniProtKB/TrEMBL),   A0A0G2K2A5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000094138   ⟸   ENSRNOT00000098889
RefSeq Acc Id: NP_001380778   ⟸   NM_001393849
- Peptide Label: isoform 1
- UniProtKB: A0A8I6GL10 (UniProtKB/TrEMBL),   A6ICP4 (UniProtKB/TrEMBL),   A0A0G2K2A5 (UniProtKB/TrEMBL)
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K2A5-F1-model_v2 AlphaFold A0A0G2K2A5 1-340 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698874
Promoter ID:EPDNEW_R9399
Type:initiation region
Name:Uchl5_1
Description:ubiquitin C-terminal hydrolase L5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01360,568,147 - 60,568,207EPDNEW


1 to 33 of 33 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-18025 BioCyc
Ensembl Genes ENSRNOG00000003545 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004881 ENTREZGENE
  ENSRNOT00000004881.7 UniProtKB/TrEMBL
  ENSRNOT00000077153.2 UniProtKB/TrEMBL
  ENSRNOT00000098889 ENTREZGENE
  ENSRNOT00000098889.1 UniProtKB/TrEMBL
  ENSRNOT00000140387 ENTREZGENE
  ENSRNOT00000150460 ENTREZGENE
Gene3D-CATH 1.20.58.860 UniProtKB/TrEMBL
  3.40.532.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7125859 IMAGE-MGC_LOAD
InterPro Papain_like_cys_pep_sf UniProtKB/TrEMBL
  Peptidase_C12 UniProtKB/TrEMBL
  Peptidase_C12_UCH_sf UniProtKB/TrEMBL
  Ubiquitinyl_hydrolase_UCH37 UniProtKB/TrEMBL
  UCH37 UniProtKB/TrEMBL
  UCH_C UniProtKB/TrEMBL
MGC_CLONE MGC:105874 IMAGE-MGC_LOAD
NCBI Gene 360853 ENTREZGENE
PANTHER Peptidase_C12 UniProtKB/TrEMBL
  UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5 UniProtKB/TrEMBL
Pfam Peptidase_C12 UniProtKB/TrEMBL
  UCH_C UniProtKB/TrEMBL
PhenoGen Uchl5 PhenoGen
PIRSF Ubiquitinyl_hydrolase_UCH37 UniProtKB/TrEMBL
PRINTS UBCTHYDRLASE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003545 RatGTEx
Superfamily-SCOP SSF54001 UniProtKB/TrEMBL
UniProt A0A0G2K2A5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GL10 ENTREZGENE, UniProtKB/TrEMBL
  A6ICP4 ENTREZGENE, UniProtKB/TrEMBL
  Q5HZY3 ENTREZGENE, UniProtKB/TrEMBL
1 to 33 of 33 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Uchl5  ubiquitin C-terminal hydrolase L5  Uchl5  ubiquitin carboxyl-terminal hydrolase L5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-08-29 Uchl5  ubiquitin carboxyl-terminal hydrolase L5  Uchl5  ubiquitin carboxyl-terminal esterase L5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Uchl5  ubiquitin carboxyl-terminal esterase L5  Uchl5  ubiquitin carboxyl-terminal hydrolase L5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Uchl5  ubiquitin carboxyl-terminal hydrolase L5  Uchl5_predicted  ubiquitin carboxyl-terminal hydrolase L5 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Uchl5_predicted  ubiquitin carboxyl-terminal hydrolase L5 (predicted)      Symbol and Name status set to approved 70820 APPROVED