Mdm2 (MDM2 proto-oncogene) - Rat Genome Database

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Gene: Mdm2 (MDM2 proto-oncogene) Rattus norvegicus
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Symbol: Mdm2
Name: MDM2 proto-oncogene
RGD ID: 1305332
Description: Enables p53 binding activity; signaling receptor binding activity; and ubiquitin protein ligase activity. Involved in several processes, including cellular response to UV-C; cellular response to estrogen stimulus; and regulation of macromolecule metabolic process. Is active in glutamatergic synapse and postsynaptic density. Used to study ichthyosis; post-traumatic stress disorder; and transient cerebral ischemia. Biomarker of breast cancer; intermittent claudication; liver disease; and priapism. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; glioblastoma; hepatocellular carcinoma; pancreatic ductal carcinoma; and sarcoma. Orthologous to human MDM2 (MDM2 proto-oncogene); PARTICIPATES IN altered p53 signaling pathway; p53 signaling pathway; cell cycle pathway, mitotic; INTERACTS WITH (+)-schisandrin B; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: double minute 2; E3 ubiquitin-protein ligase Mdm2; LOC314856; MDM2 oncogene, E3 ubiquitin protein ligase; Mdm2 p53 binding protein homolog; Mdm2 p53 binding protein homolog (mouse); MDM2 proto-oncogene, E3 ubiquitin protein ligase; p53 E3 ubiquitin protein ligase; transformed mouse 3T3 cell double minute 2; transformed mouse 3T3 cell double minute 2 homolog (mouse)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8755,176,558 - 55,201,757 (-)NCBIGRCr8
mRatBN7.2753,290,660 - 53,315,205 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl753,290,664 - 53,314,915 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx755,197,377 - 55,221,597 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0757,400,491 - 57,424,715 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0757,178,368 - 57,202,590 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0760,719,060 - 60,743,618 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl760,719,066 - 60,743,328 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0760,719,023 - 60,743,581 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4756,996,694 - 57,020,926 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1757,018,654 - 57,054,110 (-)NCBI
Celera750,062,029 - 50,086,121 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Mdm2RatAcute Experimental Pancreatitis  IEP 2317361protein:increased expression:pancreas (rat)RGD 
Mdm2Ratacute myeloid leukemia disease_progressionISORGD:131329911251749 RGD 
Mdm2Ratbiliary tract benign neoplasm  ISORGD:13132992317415protein:increased expression:biliary epithelium (human)RGD 
Mdm2RatBrain Injuries  IEP 2317397protein:increased expression:brain cortex (rat)RGD 
Mdm2Ratbreast cancer  IEP 2293626protein:increased expression:breast tumor (rat)RGD 
Mdm2RatChemotherapy-Induced Febrile Neutropenia susceptibilityISORGD:131329911073725associated with Breast Neoplasms;DNA:SNP:cds:309T>G(rs2279744)(human)RGD 
Mdm2Ratcholangiocarcinoma disease_progressionISORGD:13132992317417protein:increased expression:intrahepatic bile duct (human)RGD 
Mdm2Ratchronic myeloid leukemia onsetISORGD:131329913703044DNA:SNP:promoter:rs2279744(human)RGD 
Mdm2RatDrug-induced Neutropenia susceptibilityISORGD:131329911073715associated with Small Cell Lung Carcinoma;DNA:SNP::rs2279744(human)RGD 
Mdm2RatExperimental Diabetes Mellitus  IEP 10412313protein:increased degradation:myocardiumRGD 
Mdm2RatFetal Growth Retardation  IEP 2317395mRNA:decreased expression:cerebrum (rat)RGD 
Mdm2Ratglioblastoma  ISORGD:131329913702089DNA:amplicationRGD 
Mdm2Rathepatocellular carcinoma susceptibilityISORGD:13132992317357DNA:transversion:promoter:g.-309T>G (human)RGD 
Mdm2RatHypothermia  IEP 2317393associated with Reperfusion Injury; protein:increased expression:hippocampus (rat)RGD 
Mdm2Ratichthyosis treatmentIMP 10412066 RGD 
Mdm2Ratichthyosis  ISORGD:131329910412066 RGD 
Mdm2Ratintermittent claudication treatmentIEP 9586024 RGD 
Mdm2RatIntimal Hyperplasia treatmentISORGD:131330010412065 RGD 
Mdm2RatIntracranial Subdural Hematoma treatmentIMP 155882538 RGD 
Mdm2Ratliver disease onsetIEP 2317409protein:increased expression:Enzyme altered focus (rat)RGD 
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Mdm2Ratdisease of cellular proliferation  ISORGD:13132998554872ClinVar Annotator: match by term: Accelerated tumor formation, susceptibility toClinVarPMID:15550242|PMID:16258005|PMID:17003841|PMID:17360557|PMID:17576681|PMID:19521721|PMID:28492532|PMID:9536098
Mdm2Ratdisease of cellular proliferation  ISORGD:13132998554872ClinVar Annotator: match by term: Accelerated tumor formation, susceptibility toClinVarPMID:15550242|PMID:16199547|PMID:16258005|PMID:17003841|PMID:17360557|PMID:17576681|PMID:19521721|PMID:23653682|PMID:25741868|PMID:28492532|PMID:28846075|PMID:9536098
Mdm2Ratdisease of cellular proliferation  ISORGD:13132998554872ClinVar Annotator: match by term: Accelerated tumor formation, susceptibility to | ClinVar Annotator: match by more ...ClinVarPMID:15550242|PMID:16199547|PMID:16258005|PMID:17003841|PMID:17360557|PMID:17576681|PMID:19521721|PMID:23653682|PMID:28492532|PMID:9536098
Mdm2RatLessel-Kubisch Syndrome  ISORGD:13132998554872ClinVar Annotator: match by term: Lessel-kubisch syndrome | ClinVar Annotator: match by term: MDM2-related conditionClinVarPMID:25741868|PMID:28492532|PMID:28846075
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Mdm2RatBreast Neoplasms  ISORGD:131329911554173CTD Direct Evidence: marker/mechanismCTDPMID:26229107
Mdm2Rathuman immunodeficiency virus infectious disease  ISORGD:131329911554173CTD Direct Evidence: marker/mechanismCTDPMID:12878215
Mdm2Ratlung non-small cell carcinoma  ISORGD:131329911554173CTD Direct Evidence: marker/mechanismCTDPMID:19941079|PMID:21268124
Mdm2Ratmale infertility  ISORGD:131329911554173CTD Direct Evidence: marker/mechanismCTDPMID:22773013
Mdm2Ratmelanoma  ISORGD:131329911554173CTD Direct Evidence: marker/mechanismCTDPMID:17210701
Mdm2RatNeoplastic Cell Transformation  ISORGD:131329911554173CTD Direct Evidence: marker/mechanismCTDPMID:15550242
Mdm2Ratpre-malignant neoplasm  ISORGD:131329911554173CTD Direct Evidence: marker/mechanismCTDPMID:14555611
Mdm2RatProstatic Neoplasms  ISORGD:131329911554173CTD Direct Evidence: marker/mechanismCTDPMID:20875869
Mdm2RatSAPHO syndrome  ISORGD:131329911554173CTD Direct Evidence: marker/mechanismCTDPMID:19779722
Mdm2RatStomach Neoplasms  ISORGD:131329911554173CTD Direct Evidence: marker/mechanismCTDPMID:31945315
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Mdm2RatLessel-Kubisch Syndrome  ISORGD:13132997240710 OMIM 
Mdm2RatNeoplastic Cell Transformation  ISORGD:13132997240710 OMIM 

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Mdm2Rat(+)-catechin decreases expressionISORGD:13132996480464Catechin results in decreased expression of MDM2 mRNACTDPMID:23706674
Mdm2Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of MDM2 mRNA]CTDPMID:31150632
Mdm2Rat(-)-demecolcine increases expressionISORGD:13132996480464Demecolcine results in increased expression of MDM2 mRNACTDPMID:23649840
Mdm2Rat(-)-epigallocatechin 3-gallate multiple interactionsISORGD:13133006480464[epigallocatechin gallate co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in more ...CTDPMID:23717041
Mdm2Rat(S)-naringenin multiple interactionsISORGD:13132996480464[naringenin co-treated with bisphenol A] results in increased expression of MDM2 mRNA; [naringenin metabolite co-treated more ...CTDPMID:36235125
Mdm2Rat(S)-naringenin increases expressionISORGD:13132996480464naringenin metabolite results in increased expression of MDM2 mRNACTDPMID:36235125
Mdm2Rat(S)-nicotine multiple interactionsISORGD:13132996480464[[Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 more ...CTDPMID:30272249
Mdm2Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane affects expressionISORGD:13133006480464o,p'-DDT affects the expression of MDM2 mRNACTDPMID:18925944
Mdm2Rat1,10-phenanthroline increases expressionISORGD:131329964804641,10-phenanthroline results in increased expression of MDM2 mRNACTDPMID:19502547
Mdm2Rat1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene increases phosphorylationISORGD:131329964804642,4,5,2',5'-pentachlorobiphenyl results in increased phosphorylation of MDM2 proteinCTDPMID:19751709|PMID:20840854
Mdm2Rat1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactionsISORGD:131329964804642,4,5,2',5'-pentachlorobiphenyl inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MDM2 protein]; MDM2 mutant form more ...CTDPMID:20840854
Mdm2Rat1,2-dimethylhydrazine multiple interactionsISORGD:13133006480464[1,2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of MDM2 mRNACTDPMID:22206623
Mdm2Rat1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile increases expressionEXP 6480464Citalopram results in increased expression of MDM2 mRNACTDPMID:28467792
Mdm2Rat1-nitropyrene increases expressionISORGD:131329964804641-nitropyrene results in increased expression of MDM2 mRNA; 1-nitropyrene results in increased expression of MDM2 more ...CTDPMID:10837373|PMID:22044530
Mdm2Rat1-nitropyrene multiple interactionsISORGD:13132996480464nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein more ...CTDPMID:10837373|PMID:22044530
Mdm2Rat10-Hydroxycamptothecin affects response to substanceISORGD:13132996480464MDM2 protein affects the susceptibility to 10-hydroxycamptothecinCTDPMID:13130078
Mdm2Rat17alpha-ethynylestradiol increases expressionISORGD:13132996480464Ethinyl Estradiol results in increased expression of MDM2 mRNA alternative form; Ethinyl Estradiol results in more ...CTDPMID:12168835
Mdm2Rat17alpha-ethynylestradiol increases expressionISORGD:13133006480464Ethinyl Estradiol results in increased expression of MDM2 mRNACTDPMID:17942748
Mdm2Rat17alpha-ethynylestradiol multiple interactionsISORGD:13133006480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MDM2 mRNACTDPMID:17942748
Mdm2Rat17alpha-ethynylestradiol affects expressionISORGD:13133006480464Ethinyl Estradiol affects the expression of MDM2 mRNACTDPMID:17555576

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Biological Process
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Original Reference(s)
Mdm2Ratamyloid fibril formation involved_inISORGD:13132991624291 PMID:12630860RGDPMID:12630860
Mdm2Ratamyloid fibril formation involved_inIEAUniProtKB:Q00987|ensembl:ENSP000002581491600115GO_REF:0000107EnsemblGO_REF:0000107
Mdm2Ratapoptotic process involved_inISORGD:13132991624291 PMID:30879903RGDPMID:30879903
Mdm2Ratapoptotic process involved_inIEAUniProtKB:Q00987|ensembl:ENSP000002581491600115GO_REF:0000107EnsemblGO_REF:0000107
Mdm2Ratapoptotic process involved_inIEAUniProtKB:P23804|ensembl:ENSMUSP000000204081600115GO_REF:0000107EnsemblGO_REF:0000107
Mdm2Ratapoptotic process involved_inISORGD:13133001624291 PMID:30879903RGDPMID:30879903
Mdm2Ratatrial septum development acts_upstream_of_or_withinIEAUniProtKB:P23804|ensembl:ENSMUSP000000204081600115GO_REF:0000107EnsemblGO_REF:0000107
Mdm2Ratatrial septum development acts_upstream_of_or_withinISORGD:13133001624291MGI:107934 PMID:22821713RGDPMID:22821713
Mdm2Ratatrioventricular valve morphogenesis acts_upstream_of_or_withinIEAUniProtKB:P23804|ensembl:ENSMUSP000000204081600115GO_REF:0000107EnsemblGO_REF:0000107
Mdm2Ratatrioventricular valve morphogenesis acts_upstream_of_or_withinISORGD:13133001624291MGI:107934 PMID:22821713RGDPMID:22821713
Mdm2Ratblood vessel development acts_upstream_of_or_withinIEAUniProtKB:P23804|ensembl:ENSMUSP000000204081600115GO_REF:0000107EnsemblGO_REF:0000107
Mdm2Ratblood vessel development acts_upstream_of_or_withinISORGD:13133001624291MGI:2385439 PMID:22821713RGDPMID:22821713
Mdm2Ratblood vessel remodeling acts_upstream_of_or_withinISORGD:13133001624291MGI:2385439 PMID:22821713RGDPMID:22821713
Mdm2Ratblood vessel remodeling acts_upstream_of_or_withinIEAUniProtKB:P23804|ensembl:ENSMUSP000000204081600115GO_REF:0000107EnsemblGO_REF:0000107
Mdm2Ratcardiac septum morphogenesis acts_upstream_of_or_withinIEAUniProtKB:P23804|ensembl:ENSMUSP000000204081600115GO_REF:0000107EnsemblGO_REF:0000107
Mdm2Ratcardiac septum morphogenesis acts_upstream_of_or_withinISORGD:13133001624291MGI:107934|MGI:98834 PMID:22821713RGDPMID:22821713
Mdm2Ratcellular response to actinomycin D involved_inISORGD:13132991624291 PMID:15314173RGDPMID:15314173
Mdm2Ratcellular response to actinomycin D involved_inIEAUniProtKB:Q00987|ensembl:ENSP000002581491600115GO_REF:0000107EnsemblGO_REF:0000107
Mdm2Ratcellular response to alkaloid  IEP 2317366camptothecinRGD 
Mdm2Ratcellular response to antibiotic  IEP 2317371chemotherapeutic anthracycline Adriamycin; novel Mdm2 splice variantRGD 
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Cellular Component
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Original Reference(s)
Mdm2Ratcentriolar satellite located_inISORGD:1313299|UniProtKB:Q00987-1|UniProtKB:Q00987-111624291 RGDGO_REF:0000052
Mdm2Ratcentriolar satellite located_inIEAUniProtKB:Q00987|ensembl:ENSP000002581491600115GO_REF:0000107EnsemblGO_REF:0000107
Mdm2Ratcytoplasm located_inISORGD:13132991624291 PMID:15314173, PMID:21726810, PMID:30879903RGDPMID:15314173|PMID:21726810|PMID:30879903
Mdm2Ratcytoplasm located_inIEAUniProtKB:P23804|ensembl:ENSMUSP000000204081600115GO_REF:0000107EnsemblGO_REF:0000107
Mdm2Ratcytoplasm located_inIEAUniRule:UR0006907761600115GO_REF:0000104UniProtGO_REF:0000104
Mdm2Ratcytoplasm located_inIEAUniProtKB:Q00987|ensembl:ENSP000002581491600115GO_REF:0000107EnsemblGO_REF:0000107
Mdm2Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Mdm2Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Mdm2Ratcytoplasm located_inISORGD:13133001624291 PMID:14767071, PMID:19090619RGDPMID:14767071|PMID:19090619
Mdm2Ratcytoplasm is_active_inIBAMGI:96952|PANTHER:PTN000040730|UniProtKB:Q009871600115GO_REF:0000033GO_CentralGO_REF:0000033
Mdm2Ratcytosol located_inIEAUniProtKB:Q00987|ensembl:ENSP000002581491600115GO_REF:0000107EnsemblGO_REF:0000107
Mdm2Ratcytosol located_inISORGD:1313299|UniProtKB:Q00987-1|UniProtKB:Q00987-111624291 RGDGO_REF:0000052
Mdm2Ratglutamatergic synapse is_active_inEXP 2317402PMID:14642282SynGO 
Mdm2Ratglutamatergic synapse is_active_inIMP 2317402PMID:14642282SynGO 
Mdm2Ratglutamatergic synapse is_active_inIDA 2317402PMID:14642282SynGO 
Mdm2Ratnuclear body located_inISORGD:13132991624291 PMID:10360174RGDPMID:10360174
Mdm2Ratnuclear body located_inIEAUniProtKB:Q00987|ensembl:ENSP000002581491600115GO_REF:0000107EnsemblGO_REF:0000107
Mdm2Ratnucleolus located_inISORGD:13133001624291 PMID:11718560, PMID:15195100, PMID:16129783RGDPMID:11718560|PMID:15195100|PMID:16129783
Mdm2Ratnucleolus located_inIEAUniProtKB:P23804|ensembl:ENSMUSP000000204081600115GO_REF:0000107EnsemblGO_REF:0000107
Mdm2Ratnucleolus located_inIEAUniProtKB:Q00987|ensembl:ENSP000002581491600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function
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Mdm2Rat5S rRNA binding enablesISORGD:13132991624291 PMID:24120868RGDPMID:24120868
Mdm2Rat5S rRNA binding enablesIEAUniProtKB:Q00987|ensembl:ENSP000002581491600115GO_REF:0000107EnsemblGO_REF:0000107
Mdm2Ratdisordered domain specific binding enablesISORGD:13132991624291UniProtKB:Q8N726 PMID:12630860RGDPMID:12630860
Mdm2Ratdisordered domain specific binding enablesIEAUniProtKB:Q00987|ensembl:ENSP000002581491600115GO_REF:0000107EnsemblGO_REF:0000107
Mdm2Ratenzyme binding enablesISORGD:13132991624291UniProtKB:O75604|UniProtKB:Q15392|UniProtKB:Q6PCD5|UniProtKB:Q93009 PMID:15577914, PMID:17290220, PMID:18566590, PMID:20173098RGDPMID:15577914|PMID:17290220|PMID:18566590|PMID:20173098
Mdm2Ratenzyme binding enablesIEAUniProtKB:Q00987|ensembl:ENSP000002581491600115GO_REF:0000107EnsemblGO_REF:0000107
Mdm2Ratidentical protein binding enablesISORGD:13132991624291UniProtKB:Q00987 PMID:17159902, PMID:17936559, PMID:22493164RGDPMID:17159902|PMID:17936559|PMID:22493164
Mdm2Ratidentical protein binding enablesIEAUniProtKB:Q00987|ensembl:ENSP000002581491600115GO_REF:0000107EnsemblGO_REF:0000107
Mdm2Ratidentical protein binding enablesIEAInterPro:IPR0440801600115GO_REF:0000002InterProGO_REF:0000002
Mdm2Ratligase activity enablesISORGD:13132991624291 PMID:17142452RGDPMID:17142452
Mdm2Ratligase activity enablesIEAUniProtKB:Q00987|ensembl:ENSP000002581491600115GO_REF:0000107EnsemblGO_REF:0000107
Mdm2Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Mdm2RatNEDD8 ligase activity enablesISORGD:13132991624291 PMID:18560357RGDPMID:18560357
Mdm2RatNEDD8 ligase activity enablesIEAUniProtKB:Q00987|ensembl:ENSP000002581491600115GO_REF:0000107EnsemblGO_REF:0000107
Mdm2Ratp53 binding  IPIRGD:38892316094 RGD 
Mdm2Ratp53 binding enablesIEAUniProtKB:Q00987|ensembl:ENSP000002581491600115GO_REF:0000107EnsemblGO_REF:0000107
Mdm2Ratp53 binding enablesIEAUniProtKB:P23804|ensembl:ENSMUSP000000204081600115GO_REF:0000107EnsemblGO_REF:0000107
Mdm2Ratp53 binding enablesISORGD:13133001624291PR:P02340|UniProtKB:P02340 PMID:15678128, PMID:17591690, PMID:20818388RGDPMID:15678128|PMID:17591690|PMID:20818388
Mdm2Ratp53 binding enablesISORGD:13132991624291UniProtKB:O15350|UniProtKB:P04637|UniProtKB:Q9H3D4 PMID:15053879, PMID:20173098, PMID:25417702, PMID:9529249RGDPMID:15053879|PMID:20173098|PMID:25417702|PMID:9529249
Mdm2Ratp53 binding  IPIRGD:38899588563 RGD 
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RGD Manual Annotations


  
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Mdm2Rataltered p53 signaling pathway   ISORGD:13132998663434 RGD 
Mdm2Rataltered p53 signaling pathway   ISORGD:13132992316186 RGD 
Mdm2Ratp53 signaling pathway   ISORGD:13132992316156 RGD 
Mdm2Ratp53 signaling pathway   ISORGD:13132992316155 RGD 

Imported Annotations - KEGG (archival)

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Mdm2Ratcell cycle pathway, mitotic  IEA 6907045 KEGGrno:04110
Mdm2Ratchronic myeloid leukemia pathway  IEA 6907045 KEGGrno:05220
Mdm2Ratendocytosis pathway  IEA 6907045 KEGGrno:04144
Mdm2Ratglioma pathway  IEA 6907045 KEGGrno:05214
Mdm2Ratmelanoma pathway  IEA 6907045 KEGGrno:05218
Mdm2Ratp53 signaling pathway   IEA 6907045 KEGGrno:04115
Mdm2Ratprostate cancer pathway   IEA 6907045 KEGGrno:05215
Mdm2Ratubiquitin/proteasome degradation pathway  IEA 6907045 KEGGrno:04120
Mdm2Raturinary bladder cancer pathway  IEA 6907045 KEGGrno:05219
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Imported Annotations - PID (archival)

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Mdm2Ratp53 signaling pathway   ISORGD:13132996484113 PIDPID:200206

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Reference Title
Reference Citation
1. p53 is a key molecular target of ursodeoxycholic acid in regulating apoptosis. Amaral JD, etal., J Biol Chem. 2007 Nov 23;282(47):34250-9. Epub 2007 Sep 19.
2. Role of polyamines in p53-dependent apoptosis of intestinal epithelial cells. Bhattacharya S, etal., Cell Signal. 2009 Apr;21(4):509-22. Epub 2008 Dec 24.
3. Cyclin-dependent kinase 5 regulates PSD-95 ubiquitination in neurons. Bianchetta MJ, etal., J Neurosci. 2011 Aug 17;31(33):12029-35. doi: 10.1523/JNEUROSCI.2388-11.2011.
4. Caveolin-1/PTRF upregulation constitutes a mechanism for mediating p53-induced cellular senescence: implications for evidence-based therapy of delayed wound healing in diabetes. Bitar MS, etal., Am J Physiol Endocrinol Metab. 2013 Oct 15;305(8):E951-63. doi: 10.1152/ajpendo.00189.2013. Epub 2013 Aug 13.
5. FGF1 inhibits p53-dependent apoptosis and cell cycle arrest via an intracrine pathway. Bouleau S, etal., Oncogene. 2005 Nov 24;24(53):7839-49.
6. Induction of p53 expression and function by estrogen in osteoblasts. Bovenkerk S, etal., Calcif Tissue Int. 2003 Sep;73(3):274-80.
7. Age-related retinal degeneration (arrd2) in a novel mouse model due to a nonsense mutation in the Mdm1 gene. Chang B, etal., Hum Mol Genet. 2008 Dec 15;17(24):3929-41. doi: 10.1093/hmg/ddn295. Epub 2008 Sep 18.
8. PKB/Akt activation inhibits p53-mediated HIF1A degradation that is independent of MDM2. Choy MK, etal., J Cell Physiol. 2010 Mar;222(3):635-9.
9. Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression. Colledge M, etal., Neuron. 2003 Oct 30;40(3):595-607.
10. Thyrotropin effects on ultraviolet radiation-dependent apoptosis in FRTL-5 cells. Del Terra E, etal., Thyroid. 2003 Aug;13(8):747-53.
11. Clinicopathological significance of p53 and mdm2 protein expression in human pancreatic cancer. Dong M, etal., World J Gastroenterol. 2005 Apr 14;11(14):2162-5.
12. Iron-dependent regulation of MDM2 influences p53 activity and hepatic carcinogenesis. Dongiovanni P, etal., Am J Pathol. 2010 Feb;176(2):1006-17. Epub 2009 Dec 17.
13. Long-term effects of hypothermia on neuronal cell death and the concentration of apoptotic proteins after incomplete cerebral ischemia and reperfusion in rats. Eberspacher E, etal., Acta Anaesthesiol Scand. 2005 Apr;49(4):477-87.
14. The prognostic significance of p16(INK4a)/p14(ARF) locus deletion and MDM-2 protein expression in adult acute myelogenous leukemia. Faderl S, etal., Cancer. 2000 Nov 1;89(9):1976-82.
15. Characterizing the role of MDM2 in diethylnitrosamine induced acute liver damage and development of pre-neoplastic lesions. Finnberg N, etal., Carcinogenesis. 2004 Jan;25(1):113-22. Epub 2003 Oct 10.
16. The ubiquitin ligase Mdm2 controls oligodendrocyte maturation by intertwining mTOR with G protein-coupled receptor kinase 2 in the regulation of GPR17 receptor desensitization. Fumagalli M, etal., Glia. 2015 Dec;63(12):2327-39. doi: 10.1002/glia.22896. Epub 2015 Jul 31.
17. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
18. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
19. Regulation of peroxisome proliferator-activated receptor-alpha by MDM2. Gopinathan L, etal., Toxicol Sci. 2009 Mar;108(1):48-58. Epub 2008 Dec 22.
20. Delta(9)-tetrahydrocannabinol regulates the p53 post-translational modifiers Murine double minute 2 and the Small Ubiquitin MOdifier protein in the rat brain. Gowran A, etal., FEBS Lett. 2009 Nov 3;583(21):3412-8. Epub 2009 Oct 9.
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PMID:8058315   PMID:8417333   PMID:9153395   PMID:9271120   PMID:9450543   PMID:9529249   PMID:10360174   PMID:10608892   PMID:10707090   PMID:10722742   PMID:10906133   PMID:11278372  
PMID:11718560   PMID:11983168   PMID:12145204   PMID:12154087   PMID:12630860   PMID:12915590   PMID:12927808   PMID:14767071   PMID:15053879   PMID:15195100   PMID:15199126   PMID:15314173  
PMID:15456867   PMID:15485902   PMID:15577914   PMID:15678128   PMID:15878855   PMID:16129783   PMID:16173922   PMID:16213212   PMID:16339144   PMID:16479015   PMID:16737965   PMID:16914427  
PMID:17142452   PMID:17159902   PMID:17237821   PMID:17290220   PMID:17310983   PMID:17591690   PMID:17936559   PMID:18382127   PMID:18560357   PMID:18566590   PMID:18614532   PMID:18784257  
PMID:19090619   PMID:19656744   PMID:20153724   PMID:20173098   PMID:20810912   PMID:20818388   PMID:21281824   PMID:21726810   PMID:21900752   PMID:22046440   PMID:22173032   PMID:22405968  
PMID:22493164   PMID:22821713   PMID:22835827   PMID:22869143   PMID:24003224   PMID:24120868   PMID:24506068   PMID:25058273   PMID:25063292   PMID:25417702   PMID:25720496   PMID:25912675  
PMID:28596723   PMID:28798142   PMID:29295817   PMID:29344658   PMID:30001240   PMID:30360646   PMID:30998966   PMID:31973811   PMID:35818191  



Mdm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8755,176,558 - 55,201,757 (-)NCBIGRCr8
mRatBN7.2753,290,660 - 53,315,205 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl753,290,664 - 53,314,915 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx755,197,377 - 55,221,597 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0757,400,491 - 57,424,715 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0757,178,368 - 57,202,590 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0760,719,060 - 60,743,618 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl760,719,066 - 60,743,328 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0760,719,023 - 60,743,581 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4756,996,694 - 57,020,926 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1757,018,654 - 57,054,110 (-)NCBI
Celera750,062,029 - 50,086,121 (-)NCBICelera
Cytogenetic Map7q22NCBI
MDM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381268,808,172 - 68,850,686 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1268,808,177 - 68,845,544 (+)EnsemblGRCh38hg38GRCh38
GRCh371269,201,952 - 69,244,466 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361267,488,247 - 67,520,481 (+)NCBINCBI36Build 36hg18NCBI36
Build 341267,488,246 - 67,520,481NCBI
Celera1268,865,796 - 68,903,026 (+)NCBICelera
Cytogenetic Map12q15NCBI
HuRef1266,252,410 - 66,289,884 (+)NCBIHuRef
CHM1_11269,170,604 - 69,207,918 (+)NCBICHM1_1
T2T-CHM13v2.01268,784,018 - 68,830,265 (+)NCBIT2T-CHM13v2.0
Mdm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910117,524,780 - 117,546,663 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10117,524,780 - 117,546,663 (-)EnsemblGRCm39 Ensembl
GRCm3810117,688,875 - 117,710,758 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10117,688,875 - 117,710,758 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710117,125,961 - 117,147,772 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610117,091,898 - 117,113,709 (-)NCBIMGSCv36mm8
Celera10119,626,758 - 119,648,336 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1066.32NCBI
Mdm2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545815,263,739 - 15,286,808 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545815,264,028 - 15,287,290 (+)NCBIChiLan1.0ChiLan1.0
MDM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21076,824,907 - 76,859,369 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11276,824,089 - 76,858,786 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01266,322,340 - 66,357,010 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11269,102,083 - 69,133,278 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1269,102,084 - 69,133,278 (+)Ensemblpanpan1.1panPan2
MDM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11010,936,288 - 10,963,118 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1010,893,719 - 10,962,596 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1010,869,091 - 10,894,634 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01011,060,051 - 11,086,867 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1011,016,172 - 11,087,383 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11010,928,429 - 10,953,972 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01011,174,449 - 11,199,967 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01011,296,600 - 11,322,142 (+)NCBIUU_Cfam_GSD_1.0
Mdm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494547,377,991 - 47,400,191 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365456,709,903 - 6,732,334 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MDM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl533,105,759 - 33,137,739 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1533,105,717 - 33,137,602 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2535,889,682 - 35,921,569 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MDM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11164,434,203 - 64,465,490 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1164,434,261 - 64,469,890 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037181,237,754 - 181,268,657 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

.

.
Variants in Mdm2
209 total Variants

Predicted Target Of
Summary Value
Count of predictions:759
Count of miRNA genes:296
Interacting mature miRNAs:376
Transcripts:ENSRNOT00000066767
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 37 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat

1 to 10 of 37 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000066767   ⟹   ENSRNOP00000063449
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl753,290,666 - 53,314,915 (-)Ensembl
Rnor_6.0 Ensembl760,719,066 - 60,743,328 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086116   ⟹   ENSRNOP00000069425
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl753,290,664 - 53,314,909 (-)Ensembl
Rnor_6.0 Ensembl760,719,631 - 60,742,660 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096862   ⟹   ENSRNOP00000079885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl753,290,664 - 53,309,889 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102407   ⟹   ENSRNOP00000092330
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl753,290,666 - 53,314,909 (-)Ensembl
RefSeq Acc Id: NM_001108099   ⟹   NP_001101569
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8755,176,560 - 55,200,791 (-)NCBI
mRatBN7.2753,290,666 - 53,314,915 (-)NCBI
Rnor_6.0760,719,066 - 60,743,328 (-)NCBI
Rnor_5.0760,719,023 - 60,743,581 (-)NCBI
RGSC_v3.4756,996,694 - 57,020,926 (-)RGD
Celera750,062,029 - 50,086,121 (-)RGD
Sequence:
RefSeq Acc Id: XM_006241382   ⟹   XP_006241444
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8755,176,558 - 55,201,757 (-)NCBI
mRatBN7.2753,290,660 - 53,315,205 (-)NCBI
Rnor_6.0760,719,060 - 60,743,618 (-)NCBI
Rnor_5.0760,719,023 - 60,743,581 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006241383   ⟹   XP_006241445
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8755,176,558 - 55,200,624 (-)NCBI
mRatBN7.2753,290,660 - 53,314,609 (-)NCBI
Rnor_6.0760,719,060 - 60,743,026 (-)NCBI
Rnor_5.0760,719,023 - 60,743,581 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039079127   ⟹   XP_038935055
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8755,176,558 - 55,201,757 (-)NCBI
mRatBN7.2753,290,660 - 53,315,205 (-)NCBI
RefSeq Acc Id: NP_001101569   ⟸   NM_001108099
- UniProtKB: D3ZVH5 (UniProtKB/TrEMBL),   A6IGT1 (UniProtKB/TrEMBL),   A0A8I6GK47 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241444   ⟸   XM_006241382
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GK47 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241445   ⟸   XM_006241383
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GK47 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000063449   ⟸   ENSRNOT00000066767
Ensembl Acc Id: ENSRNOP00000069425   ⟸   ENSRNOT00000086116
DM2   RanBP2-type   RING-type

Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JVC1-F1-model_v2 AlphaFold A0A0G2JVC1 1-483 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13695222
Promoter ID:EPDNEW_R5740
Type:single initiation site
Name:Mdm2_1
Description:MDM2 proto-oncogene
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5741  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0760,742,660 - 60,742,720EPDNEW
RGD ID:13695216
Promoter ID:EPDNEW_R5741
Type:initiation region
Name:Mdm2_2
Description:MDM2 proto-oncogene
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5740  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0760,743,296 - 60,743,356EPDNEW


1 to 40 of 43 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-33982 BioCyc
Ensembl Genes ENSRNOG00000006304 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066767 ENTREZGENE
  ENSRNOT00000066767.3 UniProtKB/TrEMBL
  ENSRNOT00000086116 ENTREZGENE
  ENSRNOT00000086116.2 UniProtKB/TrEMBL
  ENSRNOT00000096862.1 UniProtKB/TrEMBL
  ENSRNOT00000102407.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.245.10 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
  Zn-finger domain of Sec23/24 UniProtKB/TrEMBL
InterPro Mdm2 UniProtKB/TrEMBL
  MDM2_mRING-HC-C2H2C4 UniProtKB/TrEMBL
  p53_neg-reg_MDM_2/4 UniProtKB/TrEMBL
  SWIB_MDM2_dom_sf UniProtKB/TrEMBL
  SWIB_MDM2_domain UniProtKB/TrEMBL
  Znf_RanBP2 UniProtKB/TrEMBL
  Znf_RanBP2_sf UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
KEGG Report rno:314856 UniProtKB/TrEMBL
NCBI Gene 314856 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE MDM2 UniProtKB/TrEMBL
  OS05G0521000 PROTEIN UniProtKB/TrEMBL
Pfam SWIB UniProtKB/TrEMBL
  zf-C3HC4_3 UniProtKB/TrEMBL
  zf-RanBP UniProtKB/TrEMBL
PhenoGen Mdm2 PhenoGen
PIRSF MDM2 UniProtKB/TrEMBL
  p53_MDM_2/4 UniProtKB/TrEMBL
PROSITE SWIB_MDM2 UniProtKB/TrEMBL
  ZF_RANBP2_1 UniProtKB/TrEMBL
  ZF_RANBP2_2 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006304 RatGTEx
Superfamily-SCOP MDM2 UniProtKB/TrEMBL
  RING/U-box UniProtKB/TrEMBL
  SSF90209 UniProtKB/TrEMBL
UniProt A0A0G2JVC1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G5V3 ENTREZGENE, UniProtKB/TrEMBL
1 to 40 of 43 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-22 Mdm2  MDM2 proto-oncogene  Mdm2  MDM2 proto-oncogene, E3 ubiquitin protein ligase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-07-10 Mdm2  MDM2 proto-oncogene, E3 ubiquitin protein ligase  Mdm2  MDM2 oncogene, E3 ubiquitin protein ligase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-11-22 Mdm2  MDM2 oncogene, E3 ubiquitin protein ligase  Mdm2  p53 E3 ubiquitin protein ligase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-05 Mdm2  p53 E3 ubiquitin protein ligase  Mdm2  Mdm2 p53 binding protein homolog (mouse)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-24 Mdm2  Mdm2 p53 binding protein homolog (mouse)  Mdm2  transformed mouse 3T3 cell double minute 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-17 Mdm2  transformed mouse 3T3 cell double minute 2  Mdm2_predicted  transformed mouse 3T3 cell double minute 2 homolog (mouse) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Mdm2_predicted  transformed mouse 3T3 cell double minute 2 homolog (mouse) (predicted)    transformed mouse 3T3 cell double minute 2 (predicted)  Name updated 1299863 APPROVED
2005-01-12 Mdm2_predicted  transformed mouse 3T3 cell double minute 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED