Nqo2 (N-ribosyldihydronicotinamide:quinone dehydrogenase 2) - Rat Genome Database

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Gene: Nqo2 (N-ribosyldihydronicotinamide:quinone dehydrogenase 2) Rattus norvegicus
Analyze
Symbol: Nqo2
Name: N-ribosyldihydronicotinamide:quinone dehydrogenase 2
RGD ID: 1303320
Description: Predicted to enable several functions, including anion binding activity; dihydronicotinamide riboside quinone reductase activity; and melatonin binding activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; positive regulation of neuron apoptotic process; and positive regulation of vascular associated smooth muscle cell proliferation. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Parkinson's disease; agranulocytosis; breast cancer; and breast carcinoma. Orthologous to human NQO2 (N-ribosyldihydronicotinamide:quinone dehydrogenase 2); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC94180; N-ribosyldihydronicotinamide:quinone reductase 2; NAD(P)H dehydrogenase, quinone 2; NAD(P)H quinone dehydrogenase 2; NRH dehydrogenase [quinone] 2; NRH:quinone oxidoreductase 2; QR2; quinone reductase 2; ribosyldihydronicotinamide dehydrogenase; ribosyldihydronicotinamide dehydrogenase [quinone]
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81731,114,825 - 31,144,062 (-)NCBIGRCr8
mRatBN7.21730,909,482 - 30,938,725 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1730,909,187 - 30,938,320 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1730,723,881 - 30,752,881 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01732,327,627 - 32,356,626 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01730,719,617 - 30,748,617 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01732,131,847 - 32,158,559 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1732,132,347 - 32,158,538 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01734,023,011 - 34,051,834 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41737,255,630 - 37,283,753 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11737,258,472 - 37,286,594 (-)NCBI
Celera1730,474,024 - 30,502,465 (-)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
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Original Reference(s)
Nqo2Ratagranulocytosis  ISONQO2 (Homo sapiens)11073696associated with schizophrenia more ...RGD 
Nqo2Ratbreast carcinoma disease_progressionISONQO2 (Homo sapiens)11073689DNA:SNP: :rs1143684 (human)RGD 
Nqo2RatHyperoxic Lung Injury  ISONqo2 (Mus musculus)10769360 RGD 
Nqo2Ratmyeloid neoplasm  ISONqo2 (Mus musculus)1331842 RGD 
Nqo2RatNeointima  IMP 11073699 RGD 
Nqo2RatParkinson's disease susceptibilityISONQO2 (Homo sapiens)11073691DNA:deletion:promoter: (human)RGD 
Object Symbol
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Original Reference(s)
Nqo2Ratovarian cancer  ISONQO2 (Homo sapiens)8554872ClinVar Annotator: match by term: Ovarian cancerClinVarPMID:25741868
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Original Reference(s)
Nqo2Ratagranulocytosis  ISONQO2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:14617031
Nqo2Ratautism spectrum disorder  ISONQO2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35663546
Nqo2Ratbone marrow disease  ISONQO2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12351651
Nqo2RatBreast Neoplasms  ISONQO2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Nqo2Ratcontact dermatitis  ISONQO2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25724174
Nqo2RatExperimental Liver Cirrhosis  ISONQO2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25380136
Nqo2RatMemory Disorders  ISONQO2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20861374
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Original Reference(s)
Nqo2Ratbreast cancer susceptibilityISONQO2 (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Nqo2Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of NQO2 mRNA]CTDPMID:31150632
Nqo2Rat(1->4)-beta-D-glucan multiple interactionsISONqo2 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of NQO2 mRNACTDPMID:36331819
Nqo2Rat1,2-dichloroethane decreases expressionISONqo2 (Mus musculus)6480464ethylene dichloride results in decreased expression of NQO2 mRNACTDPMID:28960355
Nqo2Rat1,2-dimethylhydrazine multiple interactionsISONqo2 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of NQO2 mRNACTDPMID:22206623
Nqo2Rat1,2-dimethylhydrazine decreases expressionISONqo2 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of NQO2 mRNACTDPMID:22206623
Nqo2Rat17beta-estradiol multiple interactionsISONQO2 (Homo sapiens)6480464[Estradiol co-treated with Norethindrone Acetate] results in increased expression of NQO2 mRNACTDPMID:22217510
Nqo2Rat17beta-estradiol decreases expressionISONqo2 (Mus musculus)6480464Estradiol results in decreased expression of NQO2 mRNACTDPMID:39298647
Nqo2Rat17beta-estradiol increases expressionISONQO2 (Homo sapiens)6480464Estradiol results in increased expression of NQO2 mRNACTDPMID:19167446
Nqo2Rat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISONqo2 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with 2 more ...CTDPMID:28433925
Nqo2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISONQO2 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of NQO2 mRNA and Tetrachlorodibenzodioxin results in increased expression of NQO2 proteinCTDPMID:11154737 more ...
Nqo2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISONqo2 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of NQO2 mRNACTDPMID:21570461
Nqo2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISONqo2 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of NQO2 mRNACTDPMID:21889950
Nqo2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of NQO2 mRNACTDPMID:18796159 and PMID:21215274
Nqo2Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISONqo2 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with 2 more ...CTDPMID:21889950 and PMID:28433925
Nqo2Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of NQO2 mRNACTDPMID:21346803
Nqo2Rat2,6-dichloroindophenol multiple interactionsISONQO2 (Homo sapiens)6480464[NQO2 protein results in increased oxidation of 1-benzyl-1 more ...CTDPMID:20399199 and PMID:29281794
Nqo2Rat2,6-dichloroindophenol increases reductionISONQO2 (Homo sapiens)6480464NQO2 protein results in increased reduction of 2 and 6-DichloroindophenolCTDPMID:29281794
Nqo2Rat2-hydroxypropanoic acid decreases expressionISONQO2 (Homo sapiens)6480464Lactic Acid results in decreased expression of NQO2 mRNACTDPMID:30851411
Nqo2Rat3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide increases reductionISONQO2 (Homo sapiens)6480464NQO2 protein results in increased reduction of thiazolyl blueCTDPMID:29281794
Nqo2Rat3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide multiple interactionsISONQO2 (Homo sapiens)6480464resveratrol inhibits the reaction [NQO2 protein results in increased reduction of thiazolyl blue] and Tacrine inhibits the reaction [NQO2 protein results in increased reduction of thiazolyl blue]CTDPMID:29281794

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Biological Process

  

Cellular Component

  
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Original Reference(s)
Nqo2Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Nqo2Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Nqo2Ratcytosol located_inISONQO2 (Homo sapiens)1624291 PMID:10945627RGDGO_REF:0000052 and PMID:10945627
Nqo2Ratcytosol is_active_inIBAPANTHER:PTN000024521 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Nqo2Ratnucleoplasm located_inISONQO2 (Homo sapiens)1624291 RGDGO_REF:0000052

Molecular Function
1 to 16 of 16 rows

  
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Original Reference(s)
Nqo2Ratchloride ion binding enablesISONQO2 (Homo sapiens)1624291 PMID:18254726RGDPMID:18254726
Nqo2Ratdihydronicotinamide riboside quinone reductase activity enablesISONQO2 (Homo sapiens)1624291 PMID:18254726RGDPMID:18254726
Nqo2Ratdihydronicotinamide riboside quinone reductase activity enablesIEARHEA:123641600115GO_REF:0000116RHEAGO_REF:0000116
Nqo2Ratdihydronicotinamide riboside quinone reductase activity enablesIEAEC:1.10.5.11600115GO_REF:0000003UniProtGO_REF:0000003
Nqo2Ratelectron transfer activity enablesISONQO2 (Homo sapiens)1624291 PMID:10945627 and PMID:18254726RGDPMID:10945627 and PMID:18254726
Nqo2RatFAD binding enablesISONQO2 (Homo sapiens)1624291 PMID:18254726RGDPMID:18254726
Nqo2Ratmelatonin binding enablesISONQO2 (Homo sapiens)1624291 PMID:18254726RGDPMID:18254726
Nqo2Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Nqo2RatNAD(P)H dehydrogenase (quinone) activity enablesIBAMGI:103187 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Nqo2Ratoxidoreductase activity enablesISONQO2 (Homo sapiens)1624291 PMID:10945627RGDPMID:10945627
Nqo2Ratoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
Nqo2Ratoxidoreductase activity, acting on other nitrogenous compounds as donors enablesISONQO2 (Homo sapiens)1624291 PMID:10945627RGDPMID:10945627
Nqo2Ratprotein binding enablesISONQO2 (Homo sapiens)1624291UniProtKB:A1L1C6 more ...RGDPMID:16189514 more ...
Nqo2Ratprotein homodimerization activity enablesISONQO2 (Homo sapiens)1624291UniProtKB:P16083 and PMID:18254726RGDPMID:18254726
Nqo2Ratresveratrol binding enablesISONQO2 (Homo sapiens)1624291 PMID:18254726RGDPMID:18254726
Nqo2Ratzinc ion binding enablesISONQO2 (Homo sapiens)1624291 PMID:18254726RGDPMID:18254726
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Reference Title
Reference Citation
1. Loss of quinone reductase 2 function selectively facilitates learning behaviors. Benoit CE, etal., J Neurosci. 2010 Sep 22;30(38):12690-700. doi: 10.1523/JNEUROSCI.2808-10.2010.
2. Transthyretin: A key gene involved in the maintenance of memory capacities during aging. Brouillette J and Quirion R, Neurobiol Aging. 2007 May 16.
3. BALT development and augmentation of hyperoxic lung injury in mice deficient in NQO1 and NQO2. Das A, etal., Free Radic Biol Med. 2006 May 15;40(10):1843-56. Epub 2006 Feb 17.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Association of superoxide dismutases and NAD(P)H quinone oxidoreductases with prognosis of patients with breast carcinomas. Hubackova M, etal., Int J Cancer. 2012 Jan 15;130(2):338-48. doi: 10.1002/ijc.26006. Epub 2011 Apr 20.
6. Disruption of dihydronicotinamide riboside:quinone oxidoreductase 2 (NQO2) leads to myeloid hyperplasia of bone marrow and decreased sensitivity to menadione toxicity. Long DJ 2nd, etal., J Biol Chem 2002 Nov 29;277(48):46131-9. Epub 2002 Sep 25.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. NQO2 gene is associated with clozapine-induced agranulocytosis. Ostrousky O, etal., Tissue Antigens. 2003 Dec;62(6):483-91.
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. Association of NRH:quinone oxidoreductase 2 gene promoter polymorphism with higher gene expression and increased susceptibility to Parkinson's disease. Wang W, etal., J Gerontol A Biol Sci Med Sci. 2008 Feb;63(2):127-34.
14. Resveratrol inhibits angiotensin II-induced ERK1/2 activation by downregulating quinone reductase 2 in rat vascular smooth muscle cells. Zhang X, etal., J Biomed Res. 2012 Mar;26(2):103-9. doi: 10.1016/S1674-8301(12)60019-0.
15. Downregulation of quinone reductase 2 attenuates vascular smooth muscle cells proliferation and neointimal formation in balloon injured rat carotid artery. Zhang XW, etal., Cell Physiol Biochem. 2012;29(3-4):453-62. doi: 10.1159/000338499. Epub 2012 Apr 3.
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PMID:10945627   PMID:15489334   PMID:18254726   PMID:19056867   PMID:23376485   PMID:23533145   PMID:36650666  



Nqo2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81731,114,825 - 31,144,062 (-)NCBIGRCr8
mRatBN7.21730,909,482 - 30,938,725 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1730,909,187 - 30,938,320 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1730,723,881 - 30,752,881 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01732,327,627 - 32,356,626 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01730,719,617 - 30,748,617 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01732,131,847 - 32,158,559 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1732,132,347 - 32,158,538 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01734,023,011 - 34,051,834 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41737,255,630 - 37,283,753 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11737,258,472 - 37,286,594 (-)NCBI
Celera1730,474,024 - 30,502,465 (-)NCBICelera
Cytogenetic Map17p12NCBI
NQO2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3862,999,894 - 3,019,755 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl62,987,987 - 3,019,755 (+)EnsemblGRCh38hg38GRCh38
GRCh3763,000,128 - 3,019,989 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3662,945,066 - 2,964,993 (+)NCBINCBI36Build 36hg18NCBI36
Build 3462,945,229 - 2,964,993NCBI
Celera64,229,080 - 4,249,008 (+)NCBICelera
Cytogenetic Map6p25.2NCBI
HuRef62,873,204 - 2,893,131 (+)NCBIHuRef
CHM1_163,002,428 - 3,022,361 (+)NCBICHM1_1
T2T-CHM13v2.062,868,796 - 2,888,657 (+)NCBIT2T-CHM13v2.0
Nqo2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391334,148,642 - 34,172,448 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1334,148,670 - 34,172,426 (+)EnsemblGRCm39 Ensembl
GRCm381333,964,655 - 33,988,465 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1333,964,687 - 33,988,443 (+)EnsemblGRCm38mm10GRCm38
MGSCv371334,056,528 - 34,080,334 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361333,972,216 - 33,993,112 (+)NCBIMGSCv36mm8
Celera1335,093,939 - 35,117,741 (+)NCBICelera
Cytogenetic Map13A3.3NCBI
cM Map1314.01NCBI
Nqo2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546510,186,928 - 10,200,237 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546510,186,928 - 10,200,098 (-)NCBIChiLan1.0ChiLan1.0
NQO2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2517,613,398 - 17,647,746 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1613,606,253 - 13,645,470 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v062,819,422 - 2,844,765 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.162,928,021 - 2,947,304 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl62,928,021 - 2,947,304 (+)Ensemblpanpan1.1panPan2
NQO2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1353,294,776 - 3,315,438 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl353,294,850 - 3,312,836 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha353,301,901 - 3,322,549 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0353,350,127 - 3,370,739 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl353,350,161 - 3,370,710 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1353,225,857 - 3,246,468 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0353,248,146 - 3,268,605 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0354,580,552 - 4,601,200 (+)NCBIUU_Cfam_GSD_1.0
NQO2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl71,792,876 - 1,806,301 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.171,792,745 - 1,805,916 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.271,825,528 - 1,829,240 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NQO2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11769,149,197 - 69,168,476 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1769,147,937 - 69,161,045 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660442,937,996 - 2,957,287 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nqo2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475621,857,721 - 21,867,727 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475621,857,048 - 21,869,657 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Nqo2
135 total Variants

Predicted Target Of
Summary Value
Count of predictions:197
Count of miRNA genes:135
Interacting mature miRNAs:147
Transcripts:ENSRNOT00000024141
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172393042179524188Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat

1 to 10 of 41 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000024141   ⟹   ENSRNOP00000024141
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1730,909,187 - 30,938,320 (-)Ensembl
Rnor_6.0 Ensembl1732,132,347 - 32,158,538 (-)Ensembl
RefSeq Acc Id: NM_001004214   ⟹   NP_001004214
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,115,124 - 31,143,662 (-)NCBI
mRatBN7.21730,909,781 - 30,938,320 (-)NCBI
Rnor_6.01732,132,140 - 32,158,164 (-)NCBI
Rnor_5.01734,023,011 - 34,051,834 (-)NCBI
RGSC_v3.41737,255,630 - 37,283,753 (-)RGD
Celera1730,474,024 - 30,502,465 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253867   ⟹   XP_006253929
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,114,825 - 31,144,062 (-)NCBI
mRatBN7.21730,909,482 - 30,938,723 (-)NCBI
Rnor_6.01732,131,847 - 32,158,559 (-)NCBI
Rnor_5.01734,023,011 - 34,051,834 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253868   ⟹   XP_006253930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,114,825 - 31,143,777 (-)NCBI
mRatBN7.21730,909,482 - 30,938,435 (-)NCBI
Rnor_6.01732,131,847 - 32,158,263 (-)NCBI
Rnor_5.01734,023,011 - 34,051,834 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039095490   ⟹   XP_038951418
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,114,825 - 31,143,570 (-)NCBI
mRatBN7.21730,909,482 - 30,935,815 (-)NCBI
RefSeq Acc Id: XM_039095491   ⟹   XP_038951419
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,114,825 - 31,144,057 (-)NCBI
mRatBN7.21730,909,482 - 30,938,725 (-)NCBI
Protein RefSeqs NP_001004214 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253929 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253930 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951418 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951419 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH79157 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024141
GenBank Protein Q6AY80 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001004214   ⟸   NM_001004214
- UniProtKB: Q6AY80 (UniProtKB/Swiss-Prot),   A6J7H5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253929   ⟸   XM_006253867
- Peptide Label: isoform X1
- UniProtKB: Q6AY80 (UniProtKB/Swiss-Prot),   A6J7H5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253930   ⟸   XM_006253868
- Peptide Label: isoform X2
- UniProtKB: A6J7H5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024141   ⟸   ENSRNOT00000024141
RefSeq Acc Id: XP_038951419   ⟸   XM_039095491
- Peptide Label: isoform X2
- UniProtKB: A6J7H5 (UniProtKB/TrEMBL)
Flavodoxin-like fold

Name Modeler Protein Id AA Range Protein Structure
AF-Q6AY80-F1-model_v2 AlphaFold Q6AY80 1-231 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700415
Promoter ID:EPDNEW_R10939
Type:initiation region
Name:Nqo2_1
Description:N-ribosyldihydronicotinamide:quinone reductase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10940  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01732,158,204 - 32,158,264EPDNEW
RGD ID:13700416
Promoter ID:EPDNEW_R10940
Type:single initiation site
Name:Nqo2_2
Description:N-ribosyldihydronicotinamide:quinone reductase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10939  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01732,158,558 - 32,158,618EPDNEW


1 to 20 of 20 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-9596 BioCyc
Ensembl Genes ENSRNOG00000017820 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000024141 ENTREZGENE
Gene3D-CATH 3.40.50.360 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7128990 IMAGE-MGC_LOAD
InterPro Flavodoxin_fold UniProtKB/Swiss-Prot
  Flavoprotein-like_sf UniProtKB/Swiss-Prot
  NAD(P)H_dehydrogenase_qn UniProtKB/Swiss-Prot
KEGG Report rno:291084 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94180 IMAGE-MGC_LOAD
NCBI Gene 291084 ENTREZGENE
PANTHER NAD P H OXIDOREDUCTASE-RELATED UniProtKB/Swiss-Prot
  RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE] UniProtKB/Swiss-Prot
Pfam Flavodoxin_2 UniProtKB/Swiss-Prot
PhenoGen Nqo2 PhenoGen
RatGTEx ENSRNOG00000017820 RatGTEx
Superfamily-SCOP SSF52218 UniProtKB/Swiss-Prot
UniProt A0A8L2QE49_RAT UniProtKB/TrEMBL
  A6J7H5 ENTREZGENE, UniProtKB/TrEMBL
  NQO2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 20 of 20 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-08-03 Nqo2  N-ribosyldihydronicotinamide:quinone dehydrogenase 2  Nqo2  N-ribosyldihydronicotinamide:quinone reductase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-02-01 Nqo2  N-ribosyldihydronicotinamide:quinone reductase 2  Nqo2  NAD(P)H quinone dehydrogenase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-29 Nqo2  NAD(P)H quinone dehydrogenase 2  Nqo2  NAD(P)H dehydrogenase, quinone 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Nqo2  NAD(P)H dehydrogenase, quinone 2      Symbol and Name status set to approved 1299863 APPROVED
2005-02-14 Nqo2  NAD(P)H dehydrogenase, quinone 2      Symbol and Name status set to provisional 70820 PROVISIONAL