Usp11 (ubiquitin specific peptidase 11)

Gene: Usp11 (ubiquitin specific peptidase 11) Rattus norvegicus

Analyze

Symbol:

Usp11

Name:

ubiquitin specific peptidase 11

RGD ID:

1303052

Description:

Predicted to enable cysteine-type deubiquitinase activity; cysteine-type endopeptidase activity; and transcription corepressor binding activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human USP11 (ubiquitin specific peptidase 11); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

deubiquitinating enzyme 11; MGC105909; ubiquitin carboxyl-terminal hydrolase 11; ubiquitin specific protease 11; ubiquitin thioesterase 11; ubiquitin-specific-processing protease 11; Uhx1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	USP11 (ubiquitin specific peptidase 11)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Usp11 (ubiquitin specific peptidase 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Usp11 (ubiquitin specific peptidase 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	USP11 (ubiquitin specific peptidase 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	USP11 (ubiquitin specific peptidase 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Usp11 (ubiquitin specific peptidase 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	USP11 (ubiquitin specific peptidase 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	USP11 (ubiquitin specific peptidase 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Usp11 (ubiquitin specific peptidase 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	USP11 (ubiquitin specific peptidase 11)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Usp11 (ubiquitin specific peptidase 11)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	usp11 (ubiquitin specific peptidase 11)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	UBP12	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	H34C03.2	Alliance	DIOPT (InParanoid\|PANTHER\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	4,026,865 - 4,043,036 (-)	NCBI		GRCr8
mRatBN7.2	X	1,473,349 - 1,489,520 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	1,473,350 - 1,489,520 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	1,507,286 - 1,523,463 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	4,982,988 - 4,999,165 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	1,298,355 - 1,314,525 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	1,687,820 - 1,703,991 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	1,687,811 - 1,704,033 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	2,481,251 - 2,497,422 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	12,890,515 - 12,906,686 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	12,896,694 - 12,903,135 (-)	NCBI
Celera	X	2,037,481 - 2,053,652 (-)	NCBI		Celera
Cytogenetic Map	X	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

bronchiectasis (ISO)

congenital disorder of glycosylation type IIm (ISO)

genetic disease (ISO)

immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome (ISO)

neurodegeneration with brain iron accumulation 5 (ISO)

Neurodevelopmental Disorders (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

X-linked epilepsy with variable learning disabilities and behavior disorders (ISO)

X-linked severe congenital neutropenia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2-methoxyethanol (EXP)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrolein (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

cadmium dichloride (ISO)

caffeine (EXP)

carbon nanotube (ISO)

CGP 52608 (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

Cuprizon (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

enzyme inhibitor (ISO)

epoxiconazole (ISO)

ethanol (ISO)

fenvalerate (EXP)

folic acid (ISO)

formaldehyde (ISO)

FR900359 (ISO)

genistein (ISO)

gentamycin (EXP)

hexane (EXP)

indole-3-methanol (EXP)

ivermectin (ISO)

methapyrilene (ISO)

methoxyacetic acid (EXP)

methyl methanesulfonate (ISO)

methylmercury chloride (EXP)

Monobutylphthalate (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

SB 431542 (ISO)

sodium fluoride (ISO)

sunitinib (ISO)

trichloroethene (EXP)

Triptolide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

proteolysis (IEA)

ubiquitin-dependent protein catabolic process (TAS)

Cellular Component

chromosome (IEA)

cytoplasm (IEA)

cytosol (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IBA,ISO,ISS)

Molecular Function

cysteine-type deubiquitinase activity (IEA,ISO)

cysteine-type endopeptidase activity (ISO,ISS,TAS)

protein binding (ISO)

transcription corepressor binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM.	Ideguchi H, etal., Biochem J 2002 Oct 1;367(Pt 1):87-95.
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:15060002	PMID:15314155	PMID:26334325	PMID:36898475	PMID:37000116

Genomics

Comparative Map Data

Usp11
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	4,026,865 - 4,043,036 (-)	NCBI		GRCr8
mRatBN7.2	X	1,473,349 - 1,489,520 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	1,473,350 - 1,489,520 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	1,507,286 - 1,523,463 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	4,982,988 - 4,999,165 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	1,298,355 - 1,314,525 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	1,687,820 - 1,703,991 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	1,687,811 - 1,704,033 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	2,481,251 - 2,497,422 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	12,890,515 - 12,906,686 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	12,896,694 - 12,903,135 (-)	NCBI
Celera	X	2,037,481 - 2,053,652 (-)	NCBI		Celera
Cytogenetic Map	X	q11	NCBI

USP11
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	47,233,009 - 47,248,328 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	47,232,866 - 47,248,328 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	47,092,408 - 47,107,727 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	46,977,258 - 46,992,671 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	46,848,567 - 46,863,981	NCBI
Celera	X	51,287,607 - 51,302,967 (+)	NCBI		Celera
Cytogenetic Map	X	p11.3	NCBI
HuRef	X	44,802,084 - 44,817,144 (+)	NCBI		HuRef
CHM1_1	X	47,123,812 - 47,139,152 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	46,642,700 - 46,657,954 (+)	NCBI		T2T-CHM13v2.0

Usp11
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	20,570,148 - 20,586,778 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	20,570,145 - 20,586,778 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	20,703,909 - 20,720,539 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	20,703,906 - 20,720,539 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	20,281,035 - 20,297,665 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	19,860,891 - 19,877,498 (+)	NCBI		MGSCv36	mm8
Celera	X	18,833,854 - 18,850,416 (+)	NCBI		Celera
Cytogenetic Map	X	A1.3	NCBI
cM Map	X	16.2	NCBI

Usp11
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955516	841,114 - 857,322 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955516	840,708 - 858,201 (-)	NCBI	ChiLan1.0	ChiLan1.0

USP11
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	48,860,378 - 48,875,754 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	48,863,754 - 48,879,130 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	39,669,761 - 39,685,231 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	47,527,652 - 47,543,036 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	47,527,673 - 47,542,638 (+)	Ensembl	panpan1.1		panPan2

USP11
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	40,826,648 - 40,842,700 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	40,810,500 - 40,842,700 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	15,201,810 - 15,217,862 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	40,960,674 - 40,976,724 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	40,944,527 - 40,976,724 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	40,948,358 - 40,964,409 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	40,936,214 - 40,952,266 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	41,029,319 - 41,045,370 (+)	NCBI		UU_Cfam_GSD_1.0

Usp11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	33,162,462 - 33,180,022 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936502	13,003,261 - 13,020,388 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936502	13,003,214 - 13,020,772 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

USP11
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	41,851,602 - 41,866,355 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	41,851,534 - 41,866,357 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	46,746,245 - 46,761,054 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

USP11
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	44,420,305 - 44,438,564 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	44,419,831 - 44,438,616 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666076	9,678,520 - 9,694,679 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Usp11
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624887	4,000,739 - 4,018,301 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624887	4,001,444 - 4,018,175 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Usp11
17 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	480
Count of miRNA genes:	245
Interacting mature miRNAs:	293
Transcripts:	ENSRNOT00000051956
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
731181	Uae27	Urinary albumin excretion QTL 27	2.7	0.0059	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	X	1	43491017	Rat
70166	Bp65	Blood pressure QTL 65	5.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	X	1447972	11374346	Rat
634325	Bw13	Body weight QTL 13	0		body mass (VT:0001259)	body weight (CMO:0000012)	X	1447972	20991088	Rat
70165	Bp64	Blood pressure QTL 64	5.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	X	1448129	31706553	Rat

Markers in Region

RH140271

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	1,473,358 - 1,473,553 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	1,687,830 - 1,688,024	NCBI	Rnor6.0
Rnor_5.0	X	2,481,261 - 2,481,455	UniSTS	Rnor5.0
RGSC_v3.4	X	12,890,525 - 12,890,719	UniSTS	RGSC3.4
Celera	X	2,037,491 - 2,037,685	UniSTS
Cytogenetic Map	X	q12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2	30	34	18	19	18			74	30	41	11
Low	1	13	23	23		23	8	11		5			8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001008861	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC120727	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC090333	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC105613	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BN000322	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000051956 ⟹ ENSRNOP00000042897

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	1,473,350 - 1,489,520 (-)	Ensembl
Rnor_6.0 Ensembl	X	1,687,811 - 1,704,033 (-)	Ensembl

RefSeq Acc Id:

NM_001008861 ⟹ NP_001008861

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	4,026,865 - 4,043,036 (-)	NCBI
mRatBN7.2	X	1,473,349 - 1,489,520 (-)	NCBI
Rnor_6.0	X	1,687,820 - 1,703,991 (-)	NCBI
Rnor_5.0	X	2,481,251 - 2,497,422 (-)	NCBI
RGSC_v3.4	X	12,890,515 - 12,906,686 (-)	RGD
Celera	X	2,037,481 - 2,053,652 (-)	RGD

Sequence:

show sequence

CGGACGGTGATGGCGGCGGTCGCAGCGGACCCAGCTGCAGCTGCCGTCCCGGCCTCTGCTGAGG
ACAGAGAGACACAGCCCGAGGCAATGCCAGACCTGGATCAACAGTGGCGCCAAATCGGGAATGG
GCGAGAGCGTCCACTGCGAGCTGGCGAAAGCTGGTTCCTTGTGGAGAAACACTGGTATAAACAG
TGGGAGGCGTATGTGAAGGGAGGGGATCAAGATGCTAGCACCTTTCCTGGCAGTATCAACAATT
CGGGGCTCTTTGAAGATCAGATAAGCTGGCACCTCAGGGAGAGACTGGTAGAAGGAGATGATTA
TGTGCTGCTCCCAGCGCCTGCTTGGAACTACCTGGTCAGCTGGTATGGCTTAAAGGATGACCAG
CCACCTATTGAGCGCAAGGTCATAGAACTTCCTGGCATTCGAAAGGTGGAAGTGTACCCAATAG
AGCTGCTGCTCGTTCAGCACAGTGATATGGAAACAGCTCTCACCATTCAGTTTAGCTATTCTGA
TTCTGTCGACCTAGTCTTGCAAACAGCCCGGGAGCAGTTTCTGGTAGAGCCTCAGGAAGACACG
CGCCTCTGGACCAAGAACTCAGAGGGCTCTTTGGATCGATTATGTAACACGCAGATCACACTGC
TTGATGCCTGCCTTGAGACTGGGCAGTTGGTCATCATGGAGACCCGAAACAAAGATGGCACTTG
GCCCAGCGCTCAGCTGTGTGGCATGAACAACATGCCGGACGAGGATGAGGACTTCCAGGGCCAA
CCAGGCATCTGTGGCCTTACCAATCTGGGCAACACGTGCTTCATGAACTCGGCCCTACAGTGCC
TCAGCAATGTGCCACAGCTTACGGAGTACTTTCTCAACAACCGCTACCTGGAGGAGCTCAACTT
CCGGAACCCTCTGGGCATGAAGGGTGAGCTTGCTGAGGCCTATGCAGATCTGGTAAAGCAGACT
TGGTCTGGCTACCACCGCTCCATTGTGCCGAATGTTTTCAAGAACAAGGTTGGCCATTTCGCAT
CCCAGTTTCTGGGCTACCAGCAGCATGACTCACAGGAACTACTGTCATTCCTCCTGGATGGACT
ACATGAGGACCTCAATCGAGTCAAAAAGAAAGAATATGTTGAGCTATGCAATGGTGCTGGGCGG
CCTGATCTGGAAGTGGCTCAGGAAGCCTGGCAGAACCACAAACGACGAAATGATTCTGTGATTG
TGGACACTTTCCATGGCCTCTTCAAGTCTACACTGGTGTGCCCTGATTGTGGCAATGTTTCTGT
GACCTTTGACCCCTTCTGCTACCTCAGTGTCCCACTGCCTGTCTGCTCCAGGAGGGTCTTGGAG
GTCTTCTTTGTCCCCATGGATCCCCGCCGCAAGCCAGAACAGCACCGGGTTGTAGTCCCTAAGA
AGGGCAATATCTCAGATCTGTGTGTGGCTCTGTCCACACATACAAGTGTTGCACCAGATAAGAT
GATAGTAGCTGATGTCTTCAGTCACCGATTCTATAAGCTCTACCAGCTGGAGGATCCTCTGAGT
GGCATCTTGGATCGTGATGATATCTTTGTATATGAGGTGACTGGACGGATTGAGCCTGTTGAGG
GTTCAAGAGATGATATTGTGGTTCCTGTTTACCTGCGGGAGCGCACCCCGTCCAGAGACTACAA
CAACTCCTACTACGGTCTGATACTTTTTGGGCACCCTCTCCTGGTGTCAGTGCCCCGGGACCGG
TTCTCCTGGGAGGGCCTATATAACATCTTGATGTACCGGCTTTCACGATATGTGACCAAACCCA
CCTCAGATGACGATGATGGGGATGAGAAAGGTGATGAGAATGAGGATGAGGATGTCGAAGATGA
CAGCAGCAGTGAAGAAGAAAAGGAGGAAATGTCTGGACCTACCGATAATGATGGTACCCAAGAA
TCAGAGCAGGAGCAGGCTGGGACCAGCTCTGGGGTCACCGGAAGATGCCCATCCCTCTTAGACA
ACAGCCTCCACACATCGCAGTGGCCCCCAAGGCGACGACGAAAGCAATTGTTTACTCTGCAGAC
AGTGAACTCCAATGGAACCAGTGACCGGACCACCTCCCCTGAAGAAGCCCAAACTCAGCCGTAC
ATTGCCATGGATTGGGAACCAGAGATGAAGAGGCGCTATTATGATGAAGTAGAGGCTGAGGGCT
ATGTGAAGCATGACTGCGTGGGATACATGCTGAAGAAGAATCCAGTGCAGCTGAAGGAGTGCAT
CAAACTCTTCACCACTGTGGAAACCCTTGAGAAGGAGAACCCTTGGTATTGCTCCTCCTGCAAG
CAGCACCAGCTAGCCACTAAGAAACTGGACCTCTGGATGCTACCTGAAGTTCTCATTATCCATC
TGAAGCGTTTTTCATTTTCCAAATTTTCCCGGGAGAAGCTGGACACCCTGGTGCAGTTTCCTAT
CCGGGATCTGGATTTCTCTGAGTTTGTCATCAAACCAAAGAATGAGTCTGCTCCAGACCTGTAC
AAATATGATCTCATCGCAGTTTCCAACCATTATGGTGGCATGCGTGATGGACACTATACAACAT
TTGCCTGCAACAAGGACAGTGGCCAGTGGCACTACTTTGATGACAACAGTGTCTCACCTGTGAA
TGAGAATCAGATTGAGTCCAAGGCAGCCTATGTCTTGTTCTATCAACGCCAAGATGTGGGTCGA
CGCCAGTCCCAGACTGCTTCATCTGAGACCCCCACCTCTCCTGCTTCGAGTTCTACACCCAACT
CTGACATCATGGATGTCAACTAAGGAGACCTGAAACCTATTGCAGAGAAGGAAGCCCCCTTTGC
CACTCTTTCTTGTCTACTCTCTCTCTTACTTGTGTTCATCTTTCCCCTCCCCCCAACATTGCAG
GCTTAGTCTGTTGCTACTGTTCTCTTGTACCGCTGTATTACTCTCTCAGAAAGAAGAGGCCCTG
TGCCCCTGGCGGTGTGCTCCTGCCTGTGTGTGCCCGTACAGCAGTGACTTCCCCTCCTAGTCTT
ATTTATGCTCCCCTTCCCTCTTTTCCTCATGCCAAAGTGTTCTTAGTGGCTGATTCGGGGGGGT
TCACATGAACACAGAGTGTATTTTCTTATTGAGACCATACCTTCTCTGTGTTAAGTATACATAA
AAAGACCAAGACTCCTATGTTCAGCAGTGTGGTTTATTTCTTCGTATGTACTTATTATGCACCA
GCCATAGGTCTTTGTTCTGTGTAATTACTGAAGGTATGTGGTTGATGCTATTCTGAATGGGTTT
GTTGATTTTGAGACAGGGTCTGTCTGTATAGCTCTCGATGTCCTGGAACTCACTGTGGACCAGG
CTGACCTTCAGCTCAGAAATTAGGCCTCTGCCTCCTAAGTGCTGGGATTAAAGGTATGGCTACA
ACACCTAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001008861	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH90333	(Get FASTA)	NCBI Sequence Viewer
	AAI05614	(Get FASTA)	NCBI Sequence Viewer
	CAE48377	(Get FASTA)	NCBI Sequence Viewer
	EDL97708	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000042897.6
GenBank Protein	Q5D006	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001008861 ⟸ NM_001008861

- UniProtKB:

F7FEA4 (UniProtKB/Swiss-Prot), Q0D2L8 (UniProtKB/Swiss-Prot), Q5D006 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAVAADPAAAAVPASAEDRETQPEAMPDLDQQWRQIGNGRERPLRAGESWFLVEKHWYKQWEA
YVKGGDQDASTFPGSINNSGLFEDQISWHLRERLVEGDDYVLLPAPAWNYLVSWYGLKDDQPPI
ERKVIELPGIRKVEVYPIELLLVQHSDMETALTIQFSYSDSVDLVLQTAREQFLVEPQEDTRLW
TKNSEGSLDRLCNTQITLLDACLETGQLVIMETRNKDGTWPSAQLCGMNNMPDEDEDFQGQPGI
CGLTNLGNTCFMNSALQCLSNVPQLTEYFLNNRYLEELNFRNPLGMKGELAEAYADLVKQTWSG
YHRSIVPNVFKNKVGHFASQFLGYQQHDSQELLSFLLDGLHEDLNRVKKKEYVELCNGAGRPDL
EVAQEAWQNHKRRNDSVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPLPVCSRRVLEVFF
VPMDPRRKPEQHRVVVPKKGNISDLCVALSTHTSVAPDKMIVADVFSHRFYKLYQLEDPLSGIL
DRDDIFVYEVTGRIEPVEGSRDDIVVPVYLRERTPSRDYNNSYYGLILFGHPLLVSVPRDRFSW
EGLYNILMYRLSRYVTKPTSDDDDGDEKGDENEDEDVEDDSSSEEEKEEMSGPTDNDGTQESEQ
EQAGTSSGVTGRCPSLLDNSLHTSQWPPRRRRKQLFTLQTVNSNGTSDRTTSPEEAQTQPYIAM
DWEPEMKRRYYDEVEAEGYVKHDCVGYMLKKNPVQLKECIKLFTTVETLEKENPWYCSSCKQHQ
LATKKLDLWMLPEVLIIHLKRFSFSKFSREKLDTLVQFPIRDLDFSEFVIKPKNESAPDLYKYD
LIAVSNHYGGMRDGHYTTFACNKDSGQWHYFDDNSVSPVNENQIESKAAYVLFYQRQDVGRRQS
QTASSETPTSPASSSTPNSDIMDVN

hide sequence

RefSeq Acc Id:

ENSRNOP00000042897 ⟸ ENSRNOT00000051956

Protein Domains

DUSP USP

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5D006-F1-model_v2	AlphaFold	Q5D006	1-921	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701694

Promoter ID:

EPDNEW_R12218

Type:

single initiation site

Name:

Usp11_1

Description:

ubiquitin specific peptidase 11

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	X	1,704,016 - 1,704,076	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1303052	AgrOrtholog
BioCyc Gene	G2FUF-3190	BioCyc
Ensembl Genes	ENSRNOG00000009049	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000051956.6	UniProtKB/TrEMBL
Gene3D-CATH	3.30.2230.10	UniProtKB/Swiss-Prot
	Cysteine proteinases	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7190710	IMAGE-MGC_LOAD
	IMAGE:7314230	IMAGE-MGC_LOAD
InterPro	DUSP-like_sf	UniProtKB/Swiss-Prot
	Papain-like_cys_pep_sf	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
	Pept_C19_DUSP	UniProtKB/Swiss-Prot
	Peptidase_C19_UCH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ub_USP-typ	UniProtKB/Swiss-Prot
	USP_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	USP_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:408217	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:105909	IMAGE-MGC_LOAD
	MGC:124914	IMAGE-MGC_LOAD
NCBI Gene	408217	ENTREZGENE
PANTHER	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 11	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	DUSP	UniProtKB/Swiss-Prot
	Ubiquitin_3	UniProtKB/Swiss-Prot
	UCH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Usp11	PhenoGen
PROSITE	DUSP	UniProtKB/Swiss-Prot
	USP_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	USP_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	USP_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000009049	RatGTEx
SMART	DUSP	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF143791	UniProtKB/Swiss-Prot
	SSF54001	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8L2QN44_RAT	UniProtKB/TrEMBL
	F7FEA4	ENTREZGENE
	Q0D2L8	ENTREZGENE
	Q5D006	ENTREZGENE
	Q6IE71_RAT	UniProtKB/TrEMBL
	UBP11_RAT	UniProtKB/Swiss-Prot
UniProt Secondary	F7FEA4	UniProtKB/Swiss-Prot
	Q0D2L8	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-04	Usp11	ubiquitin specific peptidase 11	Usp11	ubiquitin specific protease 11	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-11-17	Usp11	ubiquitin specific protease 11			Symbol and Name status set to approved	1299863	APPROVED
2005-02-14	Usp11	ubiquitin specific protease 11			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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